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        <name type="synonym">Septoria tritici</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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    <accession>F9WWG3</accession>
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            <fullName evidence="6">UV-endonuclease UvdE</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.837"/>
    <dbReference type="eggNOG" id="ENOG502QTMI">
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    <dbReference type="HOGENOM" id="CLU_017168_1_1_1"/>
    <dbReference type="InParanoid" id="F9WWG3"/>
    <dbReference type="OMA" id="PKMHYSE"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR31290">
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    </dbReference>
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    <sequence length="759" mass="84456" checksum="114FE5F88818957A" modified="2011-10-19" version="1"> </sequence>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857082.1">
        <property type="nucleotide sequence ID" value="XM_003857034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWV2"/>
    <dbReference type="GeneID" id="13395389"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102798"/>
    <dbReference type="HOGENOM" id="CLU_1120855_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWV2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="248" mass="26235" checksum="7B406FCE1B001F8B" modified="2011-10-19" version="1">MTYTVNYKHDIMRAVQTTGSLELAAYTIKAVCHERKQQYPKSRRECNLQDLKKVRQNPKRFHFAVYGNIDPPAARAPIATQDNNGAAVVANASMAVNDAEKDEGAALNDDTLDDGATTATNTTNTVTALESSGSTASHPAPALTEGPSDGGTSLTASTTIADPADDTAPPANSSRKRSKAPPSQQSEGPAQRVPSTNHRDAARVLAIAHTLHAAAAGVLEPSGRLSARSMRAFQMALLSALRRAHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX75</accession>
    <name>F9WX75_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_32282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856798.1">
        <property type="nucleotide sequence ID" value="XM_003856750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX75"/>
    <dbReference type="STRING" id="336722.F9WX75"/>
    <dbReference type="GeneID" id="13398356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32282"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX75"/>
    <dbReference type="OMA" id="ITQYSPF"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="34607" checksum="5847BEEF52784F27" modified="2011-10-19" version="1">MASTTHHKLNTGASIPAVGFGTWQDKDAQQDAVLTALKAGYRHIDTARIYGTEPAVGAGIKASGVPRSEIFLVTKLWNNSHDPSSVESALDASLKDLGTDYVDLYLMHWPSPFKNGDNMFPKDDAGKVQTGTADYVETYKAMEECFKKGKAKAIGVSNFSKKEMERLLKETSVVPAAHQLELHPWLQQKSFSEWHASKGIHLTQYSPFGNQNEIYSKGKDLGKLMEDPVLVEIGKKYGKSGAQVALAWGIAHGRSVIPKSKTESRIKANLEGDFHLEKEDLDAIEKIDKKVRFNDPSETFGWDFYTDLEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX98</accession>
    <name>F9WX98_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856873.1">
        <property type="nucleotide sequence ID" value="XM_003856825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX98"/>
    <dbReference type="GeneID" id="13398369"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102982"/>
    <dbReference type="HOGENOM" id="CLU_2225315_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX98"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389745" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11265" checksum="2135BADC58ACCE63" modified="2011-10-19" version="1">MPAVFFWGVFALLFRVPTSRILRTNSQKKTTPPSTISHPSRGRQTSDQPVPDNAHKPPLSSADPAGTCLPPGLSLVRQARIAVTVEPGAIAATSVAAANACESRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXM2</accession>
    <name>F9WXM2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_106885</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855998.1">
        <property type="nucleotide sequence ID" value="XM_003855950.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WXM2">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXM2"/>
    <dbReference type="GeneID" id="13403225"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106885"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.359"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXM2"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="17">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="300"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="395"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="472"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="575"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="693"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="846"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP90974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1303" mass="147884" checksum="50A8068D2324BAF7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXM8</accession>
    <name>F9WXM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_65256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP90978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXM8"/>
    <dbReference type="STRING" id="336722.F9WXM8"/>
    <dbReference type="GeneID" id="13403941"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65256"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.366"/>
    <dbReference type="eggNOG" id="ENOG502QWIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016622_2_0_1"/>
    <dbReference type="InParanoid" id="F9WXM8"/>
    <dbReference type="OMA" id="NQPEFYT"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="565" mass="60393" checksum="F9ADE5E5CADC43EF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXN6</accession>
    <name>F9WXN6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cardiolipin synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_102119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856007.1">
        <property type="nucleotide sequence ID" value="XM_003855959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXN6"/>
    <dbReference type="GeneID" id="13403946"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102119"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.374"/>
    <dbReference type="eggNOG" id="ENOG502SCKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164169_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXN6"/>
    <dbReference type="OMA" id="PSHKLLW"/>
    <dbReference type="OrthoDB" id="5193244at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395414" description="Cardiolipin synthase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Cardiolipin synthase N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11348" checksum="394F6C3E4A4357CA" modified="2011-10-19" version="1">MFSLFLQFFLAALAFAAPIHDEIITIQADAWQYGTGGGIIGFIVLILDVIVWIEVAKSNRPVLHKVLWAVGVFLFPIVGMIVYWLFSNREAHNQGAGYEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXV9</accession>
    <name>F9WXV9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding WRKY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_21688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857528.1">
        <property type="nucleotide sequence ID" value="XM_003857480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXV9"/>
    <dbReference type="GeneID" id="13403099"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21688"/>
    <dbReference type="eggNOG" id="ENOG502RGVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020424_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXV9"/>
    <dbReference type="OMA" id="DVWMKDF"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="491" mass="56264" checksum="3537F915128BFC58" modified="2011-10-19" version="1" fragment="single">RTNHARMFPKKHAFSYSYLFVGVPVGLQGRVGGGNVLSVDSTRPAWFDVRSEDFLSRSTAQQGLGEKLKRYLHSQGVTDRDYAFAYLVTAPRFLRYSFNPVSFWYLYDSDARLKYMVLEVNNTFDERRMYLLKSEGVKAGNESEGNDAPKMVVFSDTWNKDFHVSPFNSRKGSYSLKAIDPLAAFQETGQVKIDNTIVLRSSKDEAKIVARVFSEGIPKEPTKITTFELVKFIAAWWWVGLATFPRIVWEAQKLFFKRKLHVWYRPETAASSIGRAYTADERALEDFFRTFVTHVVEQSNKPLRVIYEPAHNEGKEYVLYSPGFTYEEAHTHTVTLKVLSPAFYSRFIHYAHAQEAFDRECLATDEKNRTLLMDGTHALPILLHSISAVDRHTRQHLKPLSHLDTLRWSLLKRLRCPPAAASYPATVPSSSEGDYTILDIRSFPLSELDRYIQLHSHASEAYTRVAIKLFAAERLTFGIPALLKGFDMLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD1</accession>
    <name>F9WYD1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_18903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857052.1">
        <property type="nucleotide sequence ID" value="XM_003857004.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYD1"/>
    <dbReference type="GeneID" id="13395412"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18903"/>
    <dbReference type="eggNOG" id="ENOG502SXHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_1_2_1"/>
    <dbReference type="InParanoid" id="F9WYD1"/>
    <dbReference type="OMA" id="TIFDICT"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="12440" checksum="9D9B39A38E214B5C" modified="2011-10-19" version="1" fragment="single">IAVFTALVPPEYGNHRQSAHGGAIATLFDSLTGCTLALISEPGYWDGREVTRNLQINYFRPVPVSEKIRIECEIVNAGKRLATVRGLMKRDSDGTLLASCLHDKFNPVAGGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="FunCoup" id="F9WYE5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="13395418"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32600"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="InParanoid" id="F9WYE5"/>
    <dbReference type="OMA" id="YHAVMTW"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="289"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="463"/>
        </location>
    </feature>
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            <begin position="51"/>
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        </location>
    </feature>
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        <location>
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            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="536" mass="59322" checksum="6A2F39E91E8E60F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107697"/>
    <dbReference type="HOGENOM" id="CLU_1435498_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYM8"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="189" mass="20455" checksum="5E307E67771E561B" modified="2011-10-19" version="1">MDRRCFLRAKTAAREIAKTTPTAKVFATMIPPVVEPVRKTTASIQTRNATALLKRSRNSACASTLPPSSDHSRIRVEGEHLALILSASMVAVALECPVTQAATRREIHASRSRNLLVEEDVPELARLFDSDSDANGRNNWPIVTNLPQLKCCALFASHLVPHCCESLAPGLSAGSIVSIDQILCDVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYU4</accession>
    <name>F9WYU4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856021.1">
        <property type="nucleotide sequence ID" value="XM_003855973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYU4"/>
    <dbReference type="GeneID" id="13403204"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102133"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.406"/>
    <dbReference type="eggNOG" id="ENOG502SSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129945_1_0_1"/>
    <dbReference type="InParanoid" id="F9WYU4"/>
    <dbReference type="OMA" id="KHQMRID"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14511" checksum="78EAD8EE8536E0CA" modified="2011-10-19" version="1">MSNRAVPILGATVLAGAGYYFYKAGGDPKVAQKKLEADAAKVSREVRDHVPGSAKELKKDAESAGAQIQSKANQLGRDAKAEASKVDAKLEQYRQDAAAQLKQTGKEANKAIDKFDNEVEKGASQAKSGLSSWFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYV2</accession>
    <name>F9WYV2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_65322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857631.1">
        <property type="nucleotide sequence ID" value="XM_003857583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYV2"/>
    <dbReference type="FunCoup" id="F9WYV2">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYV2"/>
    <dbReference type="GeneID" id="13403966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65322"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.413"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYV2"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="41411" checksum="D51C1BD239DF7649" modified="2011-10-19" version="1">MAEGMFYNATNGYIEGIVRGYRSALLSSQQYGNLTQCETIDDVKLQLGPAYGDYLAALPPNPSTSALADKTLDKLVAEFRYLQANATGSLAKFMQYLTYSYMIDNVALLITGTLHERDTKELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIIRNTLYKNYLEDFYRFVNEEPGIKGTPTQEVMCEVLEFEADRRSINITINSFGTELSKQDRKKLYPTFGRLHPEGTLMLSRADDVEGVRIAVDGVHDYRTMMDQTGMGGGNSIGNQSGGIGGDEGKSLEDLFYQKEMEIAKLSFTYQFTHAVVYAWVKLREQEVRNITWISECIAQNQKDRVNNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY5</accession>
    <name>F9WYY5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_88971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857613.1">
        <property type="nucleotide sequence ID" value="XM_003857565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYY5"/>
    <dbReference type="GeneID" id="13403981"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88971"/>
    <dbReference type="HOGENOM" id="CLU_1251548_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYY5"/>
    <dbReference type="OrthoDB" id="3650847at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="221" mass="25378" checksum="46A0429715F5CEFD" modified="2011-10-19" version="1">MIHAYTIEIIQLLILLASMVNIYHVFGPLNHGNVSSTNNDPPPRVLSTLVFGSICLFAVDGFDNLIQLRSLTHPIQSQTLLLTRRWLFPGTLLVLKKKKKEVKFVKTTKPTALLLSMDEVKRRSRLRRMTEELQTEFNAIRAGMEFNLSRQYDSDSSDGSFGGYIREVSRLSQERDKILLPQLDEMQERFDGESCRKEEEVRSMFVAQLQELKDTFGGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ04</accession>
    <name>F9WZ04_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_17477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ04"/>
    <dbReference type="STRING" id="336722.F9WZ04"/>
    <dbReference type="GeneID" id="13394460"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17477"/>
    <dbReference type="eggNOG" id="ENOG502SHU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071111_2_0_1"/>
    <dbReference type="InParanoid" id="F9WZ04"/>
    <dbReference type="OMA" id="RESTIHH"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="209" mass="23175" checksum="0AFA1F508A6F9532" modified="2011-10-19" version="1" fragment="single">LNSNLNAAIVTIAVGPEQRLFAAHEDVLSKSEFFAEACRAQFFSSAGKRIELPRETPEVFSAILEYLYKGDYTPKINFDKKRNSWYLEHVDGGTATGLNESTIFTPSGVAVLKDTVIYCSAHRYNLPELQRLALKKQGLQSGVQCSTILSSARFAYANTSATDSKLRAHYLALIIRSRSTFKRSGTMQMEMEAGGSPLFFDLFVASKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZB0</accession>
    <name>F9WZB0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1751-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_98591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856406.1">
        <property type="nucleotide sequence ID" value="XM_003856358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZB0"/>
    <dbReference type="FunCoup" id="F9WZB0">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZB0"/>
    <dbReference type="GeneID" id="13402829"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98591"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZB0"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391145" description="DUF1751-domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91382.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36546" checksum="48649282469B825B" modified="2011-10-19" version="1" fragment="single">MPRINLPPLTRGLLLTILTLSSLNAVLRTNKWRSSLDSITSSTTNYLSSPQWAVPYLVLVPTKSIIYPWTFVTSAVVENNLVSMVVSAVVVFFGGRYLERAWGSKEFGKFVLFTSLIPNILTFLIYAIWHAVTTSPEFPTPINGLVALEAGFLVSLKQLVPEHTVSLFRGTVRMRIKHFPAVFVLSNILSGPLLGTDTALWLSLIGFSCSWTFLRFFRISEIASAATGGEASVMKGDASDTFAFVAFFPDALHPVIAPISDGIYGLLVQLRLCTPFSDEAIEAGNESAASRSEAGLPGIMNSRGGSGGGGRRAEAERRRALALKALDQRLSESRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZE9</accession>
    <name>F9WZE9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_102601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857239.1">
        <property type="nucleotide sequence ID" value="XM_003857191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZE9"/>
    <dbReference type="FunCoup" id="F9WZE9">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZE9"/>
    <dbReference type="GeneID" id="13395059"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102601"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1252"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZE9"/>
    <dbReference type="OMA" id="SWVGMRE"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP92215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="32271" checksum="3180A2D530BBDB20" modified="2011-10-19" version="1">MDPFGAEGELVNIHTAFVQGQYQSVLSDYEPSSFSDSNKLPIQVLQYRAQLALGQHSEVLKAIPASAAKQNPDLAAVRTLATYLSKPSESVVTEAESLSESAGDNLSVQLLCGTVLARAGKQEQAIQLLSKHQGSLDAVAMIVQIHLSQNRTDLALKEAKSARSFAQDALLVNLAESWIGMRQGGENYQKAFYVFEELAQAPSSAAATSLVAQAVSELHMGRVEEAETALNQALTLEPENSAAIANKLVLDTIAGRDTQELRTKLESLEKEHEMLVDLQAKREAFQAATQKYTPKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0C6</accession>
    <name>F9X0C6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_107396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Lipid-anchor</topology>
            <topology evidence="1 6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857209.1">
        <property type="nucleotide sequence ID" value="XM_003857161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0C6"/>
    <dbReference type="STRING" id="336722.F9X0C6"/>
    <dbReference type="GeneID" id="13395086"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107396"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0C6"/>
    <dbReference type="OMA" id="YQSDSAN"/>
    <dbReference type="OrthoDB" id="3649192at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="40364" checksum="DC10C4EDC566D2B3" modified="2011-10-19" version="1">MANHSSGEINAAGNISPIETKGNWFWKDSKRFLIKGVPYEPRNSSLPGPESRINPLSDDWLENLRKDIPFFHRLGINTMFIECADATQSPRQAMQLLQNEGIYVLLKLDTDLVRGDSGQLKAAKINIARMYSPDEVRKNLAIVRQTARFSIVRGYKISQSKIWTDATTKLAALHRAAVRDTKLFLKKLGLRPIPVGSSMSSDQMYRLNVIRYMTAGSPEERVDFISFGVYDWVGPSSFQMSGYKHLIKAFEAFPVPMFWGDDPESNDVSDDGDDNMDAPCYDLVQITDRGERAPKKDFERFQQNLAVINAMPQEDIVGSHEVKDYDSWRGSFKEGKAKVLVGNGGGHSQLPDRLETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0H7</accession>
    <name>F9X0H7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_84074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857112.1">
        <property type="nucleotide sequence ID" value="XM_003857064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0H7"/>
    <dbReference type="FunCoup" id="F9X0H7">
        <property type="interactions" value="922"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0H7"/>
    <dbReference type="GeneID" id="13395278"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84074"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="InParanoid" id="F9X0H7"/>
    <dbReference type="OMA" id="MQVRDRN"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="211" mass="24145" checksum="2D3582C51AF965C6" modified="2011-10-19" version="1">MRFGAPGTNLALEIYADHAHNIQLKAHSRECFHESLHKDDQMIVTFQVGDREFGGSGNLDIDFWLQDPNNQIIFNQHTVSSGDHSLTAKVDGKYEYCFSNEHWSANTKEVSFNVHGVVYVPENEADKDPLEKEIREMSELMAQVKDEQNYITLRERTHRNTAESTNARVKWWSLLQLGVLAGEGIFQVWWLKRFFEVKSSGRPSFGKGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0H9</accession>
    <name>F9X0H9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857111.1">
        <property type="nucleotide sequence ID" value="XM_003857063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0H9"/>
    <dbReference type="GeneID" id="13395279"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107517"/>
    <dbReference type="eggNOG" id="ENOG502SU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556704_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0H9"/>
    <dbReference type="OMA" id="ENGAYEM"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57528" checksum="6F0D917B1D56D41C" modified="2011-10-19" version="1">MVERQGAGPKRWAPGNDVDLPPKCLQGEQNERTPAEVSTRRTKFSRLSLSDRSSDCTADYQHHTTMDRLPEELLALICEHCDHATQKALRLASKRLHEASTPLVFEHFYMGLFKYGLLSLQDIAKSPLAKHVKELTWFPDIIPSWTKESYEKAIDMRPNFSLWLRGRKSQIQEGYEGTGITSRLYPGDPRREYEALPRHSLTKAELDAGWATFNQCAGQQARWSQDREGLLFKECISLLPNLSKAHVQCAVPFSGRTNDWPVWKKLRRHIYVGPDDFVWRQEMDEPDYAHMSGQAALCLLEALGYRASFAGTKQVKYLSVHSSHLDPYLSLMNESASNTTIRRSPAHATRYQTLLETFRHLTTLHLHIPHATVSAHVSGFGMAVETMEFLRSARHLRKLDLRFGDDEMSPDDESDSQLEDLFDSDDVLFPELQSAALATNLPAEILLKFLNNHARTLRRLELRDMLVHNVDGAIEHIPRVLKLDHVYVECLWDDASCTEGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Y5</accession>
    <name>F9X0Y5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_32913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856200.1">
        <property type="nucleotide sequence ID" value="XM_003856152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Y5"/>
    <dbReference type="STRING" id="336722.F9X0Y5"/>
    <dbReference type="GeneID" id="13394605"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32913"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.799"/>
    <dbReference type="eggNOG" id="KOG3425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0Y5"/>
    <dbReference type="OMA" id="MPLITDF"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="14176" checksum="92C820C855762DE3" modified="2011-10-19" version="1">MPIITDFTLPTSPASLETPKDTLFLAFIASNEPSTGQSWCPDVRAALPVLQKEFSSADSQDLAFVEVGQRPEWRDPMNVFRQKWVVSSVPTLVKFEKENGGLREVGRLVEGEILDQQKLKALIDGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1K7</accession>
    <name>F9X1K7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_33894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856894.1">
        <property type="nucleotide sequence ID" value="XM_003856846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1K7"/>
    <dbReference type="GeneID" id="13398267"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33894"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1K7"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="103"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="443" mass="48410" checksum="A7ABFB7B2DF601FD" modified="2011-10-19" version="1">MPSDLHSTAHRQPLLAGDKQQDYASPPQQRPTLGTRHSTSRFHERDPEILPDKSNTRQRYTLAGCFLLLSLFSFAVQTETAVYIQHDLNWTKPYCMLYFTHGSWSLLWVVQLLILRLQKLSQPWPAFWRRHVSLLTSTAQMIEHRTLVVPSHLAKASPWPYFLRTTAFVTCALTVAGGSWYVAVDLTTASDLTAIYNCSAFFAYAFAVPILHEKLRISKVIAVAIAIIGVLVVAYGDTGTAKHGSKSGGGAGGPSAPDDSEASNRAVGNLVIGVGSVLYGFYEVLYKRVACPPEHCDPIRGMLFANTFGSMIGTFTLLVLWIPLPILHFTGIETFELPRGEAAWMLVISVLSNATFSGSFLVLISLTSPVLSSVAALLTIFLVALCDQMLPPPLYSPLTTAAVAGGILIIGAFGLLSWATYREMEEEAREKKLAGDESDGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A5</accession>
    <name>F9X2A5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_55193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854913.1">
        <property type="nucleotide sequence ID" value="XM_003854865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A5"/>
    <dbReference type="FunCoup" id="F9X2A5">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2A5"/>
    <dbReference type="GeneID" id="13403523"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_55193"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="InParanoid" id="F9X2A5"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="11">
        <location>
            <begin position="272"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="12">
        <location>
            <begin position="562"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="525"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="771"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="855" mass="93639" checksum="BFC6ADD15B8D80C8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2H9</accession>
    <name>F9X2H9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_68608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855462.1">
        <property type="nucleotide sequence ID" value="XM_003855414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2H9"/>
    <dbReference type="STRING" id="336722.F9X2H9"/>
    <dbReference type="GeneID" id="13403402"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68608"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.763"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X2H9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="639" mass="69735" checksum="2ED2022D1DFA0F88" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X331</accession>
    <name>F9X331_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_37166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855046.1">
        <property type="nucleotide sequence ID" value="XM_003854998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X331"/>
    <dbReference type="GeneID" id="13400987"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37166"/>
    <dbReference type="eggNOG" id="ENOG502SHSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="InParanoid" id="F9X331"/>
    <dbReference type="OMA" id="IWDASEH"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395298" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="283" mass="31191" checksum="8FC8B2BE60FD6E80" modified="2011-10-19" version="1" fragment="single">MHFSALLALLGSLAASTAAQRYDGQFWPCNPTKNATGACPPSPGLPNSTYFIDFTKVTSIPPEWTLSNWAQLKFGPLGAEFTFNKRYDAPQLWTDFMILFGKVTIEARVANGTAMISSAVLMSDTFDEIDYEFSGNNFGQERWAAGIGQNNYFGKGVTGNYDRGEYFPVSKPQSTFHKYTIDWSPTALSWAVDGKNIRTHLASKSTPKGAYQYPQSPSKLQLGIWCAGDPSANSGTRDWAGGYTDLEGGPYTMYIKSVTIENRYPAYGYNYTDQSGSFSSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X368</accession>
    <name>F9X368_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EXG5</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_35494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855141.1">
        <property type="nucleotide sequence ID" value="XM_003855093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X368"/>
    <dbReference type="STRING" id="336722.F9X368"/>
    <dbReference type="GeneID" id="13400083"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35494"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1017"/>
    <dbReference type="InParanoid" id="F9X368"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391270" evidence="5">
        <location>
            <begin position="25"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="90"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="48258" checksum="E5792C0534FA053B" modified="2011-10-19" version="1">MLRKAALFTTAFILTFVGYQSLRSESLEESQDFHFVLEDVDPSARATLARELPLRASGRHIVDAKGARVKLASINWYGASDVDFVAGGLDVRHRDDIAITIREMGFNSVRFPYSDQMVLENPIIDPEFISANLDLLDGYDIPHDSDRKNNIEGPRALDVFTACVKAMTDAGLMVIVNDHITNAAWCDGFNLCDSSWKNDHLLGFCKIRQTTESWIENWKTIMKPFVDNPLVVGADLRNEPRGIWGTFPWENWAAAAEKASEALLKMQPDWLMFVEGTSSANDCSGVKRRPVRLSIPGRVVYSSHVYSWSGWGTLPSVPYKERPYPSFRADMVRKWGFLLDRDEAPVWVGEFGNPGHAGKGDHHYWNGLMRYLSETDADWGYWALNPRKPGTFDEETYGLLQDDWTTPKDDYRMRDLQRLMMPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3D6</accession>
    <name>F9X3D6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_36382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855760.1">
        <property type="nucleotide sequence ID" value="XM_003855712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D6"/>
    <dbReference type="FunCoup" id="F9X3D6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3D6"/>
    <dbReference type="GeneID" id="13395941"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36382"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3D6"/>
    <dbReference type="OMA" id="WSYIRPT"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="440"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="967" mass="106923" checksum="6D7874C460309EEA" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3K3</accession>
    <name>F9X3K3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854868.1">
        <property type="nucleotide sequence ID" value="XM_003854820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3K3"/>
    <dbReference type="GeneID" id="13399357"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103159"/>
    <dbReference type="eggNOG" id="ENOG502SYRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1476273_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3K3"/>
    <dbReference type="OrthoDB" id="5015154at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="183" mass="21384" checksum="78704FD134F92B47" modified="2011-10-19" version="1">MRINSNDFLEKLDFILPEQYYDDTGTPTEDLPIDKYADIENLVRDTSPTARCGKPEKPREQWLYLTDYGSRYFEWDEDFRDAVQFAQGDLKLNQTGLYFAQCGRSAKFLCGVWNTRKPALVHFLVEDYPLDALETEEKGFSYAGDMRYLRPVTVRIIEFPLEGQYTGLPWTTFPSNEHKCYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X442</accession>
    <name>F9X442_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_54793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X442"/>
    <dbReference type="FunCoup" id="F9X442">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X442"/>
    <dbReference type="GeneID" id="13403684"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54793"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="InParanoid" id="F9X442"/>
    <dbReference type="OMA" id="GWGNCRK"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="33615" checksum="C1C7BFF2BF723FBD" modified="2011-10-19" version="1" fragment="single">MSTVQQHVRPRGRLYAFGSNGSGQLGIGHMEDVSRPAEVLRNDGNSITGALYVACGGNHTIVCLNHDELASTGENEDGRCITTSEKATDRLNPSMRAIFNTGAAGLLAATWSATFVVTSTGAVMVSGTGNSGELGLGHGRFSALQAETIPSFPPPGRSVVRLSACMAHVVAVLSNGEVWGWGKGRKGQLGRPSENVWTPRKLDDLGFFAIDAVCGKDFTCIFGSPSTGEIAVLGPSGNDRFGVRANAAAAVPGWKEVAASWGSIFVLLQTGEVVAWGRDDHGQLPPPNLPPLQAIAAGSEHCLGLTEAGQVLAWGWGEHGNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X452</accession>
    <name>F9X452_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_67888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854786.1">
        <property type="nucleotide sequence ID" value="XM_003854738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X452"/>
    <dbReference type="STRING" id="336722.F9X452"/>
    <dbReference type="GeneID" id="13403680"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67888"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_2_0_1"/>
    <dbReference type="InParanoid" id="F9X452"/>
    <dbReference type="OMA" id="PHWVRTE"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="146"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="654" mass="73895" checksum="DAB2A380C996CF63" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4G8</accession>
    <name>F9X4G8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855501.1">
        <property type="nucleotide sequence ID" value="XM_003855453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4G8"/>
    <dbReference type="GeneID" id="13399627"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90830"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.681"/>
    <dbReference type="HOGENOM" id="CLU_1284183_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4G8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="215" mass="23434" checksum="3BDFE495373F0433" modified="2011-10-19" version="1">MADSTTARSLQRAEEYIANYQACRKLYQSGKLEECADAVRHYLKTIDNSSSLSFLILLAGCSVDEEAANALRQANTLWSSSRAFYAHGQTEEVETALNITRLLLDTTKRLHEATDTAHVLTKSDHVETKQDVSEKKLMSLGTHDVLQHDHEGVNAAVEPTLGHLSLGQIAVPTQQNLKPEVSSRTVLGSPTLPCTPADDEIKAETTVGGSSNKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4V3</accession>
    <name>F9X4V3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_99340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855257.1">
        <property type="nucleotide sequence ID" value="XM_003855209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4V3"/>
    <dbReference type="FunCoup" id="F9X4V3">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4V3"/>
    <dbReference type="GeneID" id="13400295"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99340"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="InParanoid" id="F9X4V3"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="627" mass="71433" checksum="7A6BBC9E71353E78" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X513</accession>
    <name>F9X513_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_27490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853826.1">
        <property type="nucleotide sequence ID" value="XM_003853778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X513"/>
    <dbReference type="STRING" id="336722.F9X513"/>
    <dbReference type="GeneID" id="13395623"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27490"/>
    <dbReference type="eggNOG" id="KOG4013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_3_2_1"/>
    <dbReference type="InParanoid" id="F9X513"/>
    <dbReference type="OMA" id="HRAFDQC"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="200" mass="21395" checksum="19D01ECB96D61CDC" modified="2011-10-19" version="1" fragment="single">LEIACFSPSSALLAASAGADRIELCANQHLGGTTPPPLWLPHIKATVQTIPIFVMIRPRGGNFCYSNVEFEEMKAQIREFETLGADGFVFGMLKEDGRGIDVERTAELVRHASPKPCTFHRAFDEVADLMKGLENVVLTGCRAILSSGGRASAEEGVEGLRELVEKADGRVTVIAGGGVRSGNIESIKKVGGVRYLHSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5I8</accession>
    <name>F9X5I8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854548.1">
        <property type="nucleotide sequence ID" value="XM_003854500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5I8"/>
    <dbReference type="GeneID" id="13395734"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103617"/>
    <dbReference type="HOGENOM" id="CLU_2428756_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5I8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="91" mass="10560" checksum="11604D01E81414F5" modified="2011-10-19" version="1" fragment="single">MFARRVVDNRRCLLHTARPKSRKHSILQSNKNQTSKYHTHNINKDALHCCSSSARYRRVLSFTIFLSFAKQYYTTSCVNSATITDISHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6V5</accession>
    <name>F9X6V5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein An-Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_99512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853782.1">
        <property type="nucleotide sequence ID" value="XM_003853734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6V5"/>
    <dbReference type="STRING" id="336722.F9X6V5"/>
    <dbReference type="GeneID" id="13395658"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99512"/>
    <dbReference type="eggNOG" id="ENOG502QUNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009483_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6V5"/>
    <dbReference type="OMA" id="WHPLGVH"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="96359" checksum="4080AE7B2EA02DAA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7B6</accession>
    <name>F9X7B6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853949.1">
        <property type="nucleotide sequence ID" value="XM_003853901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7B6"/>
    <dbReference type="GeneID" id="13395508"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103832"/>
    <dbReference type="HOGENOM" id="CLU_1866729_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7B6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15886" checksum="08EFC7BF6C3D1B8C" modified="2011-10-19" version="1">MTTYLEGHPDQAPPRPISSRGTHLARAQRRLRLRREILLDPASRRPKTRHGGLLGPAPRRPTLVYYLGSCCHRDLLLGPNSTRRMRCLGWAASALSEWGREARRRGLRMPSRRLLRRCRPTPDTQVRRRVLMPCHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X838</accession>
    <name>F9X838_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Ware S.B."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="79920" checksum="FD152176897C6DFF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X973</accession>
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            <fullName evidence="3">HMG box domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X973"/>
    <dbReference type="STRING" id="336722.F9X973"/>
    <dbReference type="GeneID" id="13399524"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39975"/>
    <dbReference type="eggNOG" id="KOG0527">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714748_0_0_1"/>
    <dbReference type="InParanoid" id="F9X973"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="27"/>
            <end position="95"/>
        </location>
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    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="17298" checksum="502141A9CB89172D" modified="2011-10-19" version="1">MQARRVSSTSQDGDSIRICVCPPGPKIAGPRNAYVLYFQHRQAQVPAEHPGLRQQEIAKIIGEQWRTLEVEIKKEWYALADEEKKRHQAQYPYYRAQPKSGRRNAYPAEMGFTPAVQELTCNRCGGITVACAPSSKKARTGIVQVHHHKRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9K4"/>
    <dbReference type="STRING" id="336722.F9X9K4"/>
    <dbReference type="GeneID" id="13397289"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80419"/>
    <dbReference type="eggNOG" id="ENOG502S7RC">
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    <dbReference type="InParanoid" id="F9X9K4"/>
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    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003390264" evidence="2">
        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="171" mass="18440" checksum="00732A19A88BA0F9" modified="2011-10-19" version="1">MSPGAIMAMKSAFPAILALLASPQFAIAAGVGVGVTIIAFGGYKIIKKIKARDEKKLLEDGVAIPESPTEEMDELRELDRIEMWRRGIADEQAASSVGTSVEGNFVTPGATRTLIEEGKITEADLKPKEKKHRKKKSRSEASGSTSKTSKTKKTKASKEPSMFRSLFKGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA24</accession>
    <name>F9XA24_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853306.1">
        <property type="nucleotide sequence ID" value="XM_003853258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA24"/>
    <dbReference type="STRING" id="336722.F9XA24"/>
    <dbReference type="GeneID" id="13399974"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41178"/>
    <dbReference type="eggNOG" id="ENOG502RKMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_2_0_1"/>
    <dbReference type="InParanoid" id="F9XA24"/>
    <dbReference type="OMA" id="FDYMSEV"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27561" checksum="7A6CCCE7E329D2C2" modified="2011-10-19" version="1" fragment="single">KQRANPSHLTVHDADFRQAEKDWHTFVEKMTETLSEIDDTVPELPVKECVFRIYRDVRFSSDPTPYKPFFSAAWSRAGRKSPYAHYYVQIGPTGKGDSFVGGGLWCPEAAATAAMRRAIDRDSARLKGVLADEAMRKHFLGGTKTDAKALKAFVEGNKSNALKTKPKGYDGDHPDIELLRLRNYTVGKKIPSEELLGEDGAKRVAELLATLKPMITYCNSVVMPDEAEGEEEDESGDDEDGDEEEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA68</accession>
    <name>F9XA68_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MgABFA2</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_40215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852988.1">
        <property type="nucleotide sequence ID" value="XM_003852940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA68"/>
    <dbReference type="STRING" id="336722.F9XA68"/>
    <dbReference type="GeneID" id="13400391"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40215"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.419"/>
    <dbReference type="eggNOG" id="ENOG502QRW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_1"/>
    <dbReference type="InParanoid" id="F9XA68"/>
    <dbReference type="OMA" id="GETSPKW"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="312"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="56471" checksum="4AD4FC1F396740E6" modified="2011-10-19" version="1">MTTFTELEVGQQASISIFSKHKLSKINDNIYGGFTEHMGRCIYGGIYDPENPNKHLIDENGFRKDVIEAMQELNVPVVRYPGGNFVATYHWLDGVGPREKRPKRPELAWLGVESNQFGTDEFMQWCKVVGTEPYLALNFGTGTLDEALAWLEYCNSKQDTYYASLRRQHGHSEPYNVKYWALGNECWGPWQVEQMTKEDYAKKAYQWAKALKMLDPSIVLILCGETGHSGWDYHVLKECLKLDQHALGGSNTASLIDMQSIHIYTASEDPVKNALAPRSAERAIEISGSLIDLARIENNVPASVPRQTICFDEWNVWDPVRAPGELGGEENYTHSDALAVAIWLNVFIRQSKYVGMANIAQSVNVISPLMTTQGGLRKQTTWWPLLLFCKYMRGTFIAAHVSCSAYEGETEPKWMRAACDTPWLDVSAAQSDDGWMSMVVVNVHLEESFEVELDGISQVSGEAVQVHSITQGTVGIDERDWDGQGNFSFPKSSITMLRWKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAN2</accession>
    <name>F9XAN2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852053.1">
        <property type="nucleotide sequence ID" value="XM_003852005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAN2"/>
    <dbReference type="GeneID" id="13393828"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92985"/>
    <dbReference type="HOGENOM" id="CLU_596130_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAN2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="459" mass="49821" checksum="8D347E179171949B" modified="2011-10-19" version="1">MAILHVINSTDAHSLSPSSLRDKELKQSSDFSAEASEMNGHDEPSSDDDYHDDRSVASDDSDYHDGRSIASDDDFTGLAAGMTGVDIEDSNTKSALIGAGITDHDFRKLRRETVAFLKAPCPLTSTVEVLNSTAVDQALSILERVDRHIQDTAPVTLSEDDRAVSLTEAKVREMNTAVETAKVSMVLLSTARDDVETADEKRLNMVLPPDKALEDKKHPYTRAMADLRKSETALKETEENSPQTEIMFNACKGSPDVESRLADASATAANEVGTGDEEHAVNALSWVGLVESGLEDAAVAFLLGPTPLKAKALGKRGIGQVLNVIDMVDDEVHDTVPGGLTAADAQHSMGARTYGKLQEDIEQAKAAVVAMQDGEGYVLEVEESTIRECIEKVGRKAKKVAMMKARRTADRKTSVENGEDAAKYLWREQTEWREDAMQNVVDLSVVEAAALSDFLADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB15</accession>
    <name>F9XB15_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_11389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852554.1">
        <property type="nucleotide sequence ID" value="XM_003852506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB15"/>
    <dbReference type="GeneID" id="13396876"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_11389"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017097_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB15"/>
    <dbReference type="OMA" id="IQIEVFR"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="235"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="569" mass="64441" checksum="D374A1100A69C4EE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCG9</accession>
    <name>F9XCG9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_109666</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852363.1">
        <property type="nucleotide sequence ID" value="XM_003852315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCG9"/>
    <dbReference type="SMR" id="F9XCG9"/>
    <dbReference type="STRING" id="336722.F9XCG9"/>
    <dbReference type="GeneID" id="13394140"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109666"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.762"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="F9XCG9"/>
    <dbReference type="OMA" id="CHIIEHQ"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391288" description="laccase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="42"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP87339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="723" mass="79050" checksum="CE4C438A23933654" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCH2</accession>
    <name>F9XCH2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_41853</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852364.1">
        <property type="nucleotide sequence ID" value="XM_003852316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCH2"/>
    <dbReference type="STRING" id="336722.F9XCH2"/>
    <dbReference type="GeneID" id="13394221"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41853"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="F9XCH2"/>
    <dbReference type="OMA" id="QMGCTAE"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="570" mass="63881" checksum="6D98F79836E91897" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ1</accession>
    <name>F9XCQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_93697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851949.1">
        <property type="nucleotide sequence ID" value="XM_003851901.1"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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                <person name="Lombard V."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851829.1">
        <property type="nucleotide sequence ID" value="XM_003851781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDG7"/>
    <dbReference type="STRING" id="336722.F9XDG7"/>
    <dbReference type="GeneID" id="13402193"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17735"/>
    <dbReference type="eggNOG" id="ENOG502SEUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061239_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDG7"/>
    <dbReference type="OMA" id="MQNNDCE"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="20344" checksum="C61F1A05D33A3669" modified="2011-10-19" version="1" fragment="single">QLDTAATQLDRLKILPNNEDWVFDFTAQQPWYNWSPGGVTNMNAATFPAARGNGLTLAMLNLGGCSILPAHFHPRASNYVVSIEGNTTTYMYEENGAHTITAVLTKGKATIFPAGSMHTMVNNGCENAQLVSALSSEDAGTLNIGAVFTNGFPPELVNAALGGAYASPEFAAKIPPIGTGANYGTEECRQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDH3</accession>
    <name>F9XDH3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_104874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851824.1">
        <property type="nucleotide sequence ID" value="XM_003851776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDH3"/>
    <dbReference type="GeneID" id="13402188"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104874"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.390"/>
    <dbReference type="HOGENOM" id="CLU_1587809_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDH3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="168" mass="19049" checksum="0B7F617759630437" modified="2011-10-19" version="1">MITQFCKYGQARQCQYYTCFRNAQTQLTALEVATKKHIANYHACNNSCYAIPGTYDAPPFCRRYQQLHDPETTHLLDTPPQSISLERTLVDETCDPCHGLRKCAYELEGRLSFLDAAFVARSLCYEHRVDAQRVHRKLLDKTYGLARSQRNIATSSLKPAGGNPAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEB1</accession>
    <name>F9XEB1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEB1"/>
    <dbReference type="GeneID" id="13393766"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104710"/>
    <dbReference type="HOGENOM" id="CLU_2489576_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEB1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="87" mass="9952" checksum="734796FF29240580" modified="2011-10-19" version="1" fragment="single">QAHTTHAHRTSTLHQATTQHKPALPNNHTSPNHPHPNHNDPPTLNPPHLNRPRRTTSEHRIHGHSRPPNVYAWNNRIQQCRAKIPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEC3</accession>
    <name>F9XEC3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_109714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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</entry>
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</entry>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="EGP86222.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
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                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        </source>
    </reference>
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            <end position="84"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Ware S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
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            <end position="100"/>
        </location>
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    <feature type="repeat" description="WD" evidence="5">
        <location>
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            <end position="239"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="457" mass="49571" checksum="E0D7844C25EEC8E4" modified="2011-10-19" version="1">MNAFLLNRQLGSIRHGELARAQNNRLLKALHGTDTKFALDQPNAGSSSNREGGPRARDVAHAAGVNSIAVDRFEGRYLISGGADSSLAIWDLEAAADSGSNLPLEVSARTSTTASLGITHLSFYPFDSLALLTTGYDGTLKLFSSETLQASATFDLAGTIYSHSTSLISTHLLVACAVQHPAVRLVDLRSGAATHSLPGHSGSVLSVAWHPRDENILASSATDGVVRLWDIRRSASSLGVLDLEDSIGLAGYDRKGTGARRRERGKSHVGAANGIVWTADGHHLVSNGHDERMRVWDMRNGANTLANFGPGLKNSGATAQLPLIAPPGSSEIGRETIFYPNPKEILAFDMHSGMLQSRLRVRGLPGSEINTNGLASRNPRNRTTSLAWRTHHVEMYSGHGDGTIRCWRPRISEDIIAEEEENEDEETETDAADRKRKREEFDRVVRDLTSQKRITFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGE9</accession>
    <name>F9XGE9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_81397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851301.1">
        <property type="nucleotide sequence ID" value="XM_003851253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGE9"/>
    <dbReference type="GeneID" id="13401133"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81397"/>
    <dbReference type="HOGENOM" id="CLU_2514381_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGE9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="85" mass="9644" checksum="840350D56DB80277" modified="2011-10-19" version="1">MSTQCLPPQQNPDLFPSQTPPTATQDSHLLLWQTKLLLAQQGAQRWHVSPALDMQPLMSMAFTFTPRATASTRNWIFMVEIFGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGF2</accession>
    <name>F9XGF2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_45399</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_45551</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
            <strain evidence="1">IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850573.1">
        <property type="nucleotide sequence ID" value="XM_003850525.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851302.1">
        <property type="nucleotide sequence ID" value="XM_003851254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGF2"/>
    <dbReference type="STRING" id="336722.F9XGF2"/>
    <dbReference type="GeneID" id="13401131"/>
    <dbReference type="GeneID" id="13401134"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45399"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45551"/>
    <dbReference type="eggNOG" id="ENOG502SCIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3056318_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGF2"/>
    <dbReference type="OMA" id="FQCERYE"/>
    <dbReference type="OrthoDB" id="3650657at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="54" mass="6258" checksum="80B235CDB5838B4D" modified="2011-10-19" version="1" fragment="single">IDKFEENRDVILLENRLFILRAEIKNGVKKSITSIIIEFTRPDDTNKIISEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGU6</accession>
    <name>F9XGU6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_45798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850473.1">
        <property type="nucleotide sequence ID" value="XM_003850425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGU6"/>
    <dbReference type="GeneID" id="13402734"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45798"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGU6"/>
    <dbReference type="OMA" id="KETEMQF"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="525"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="915"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1028"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1111" mass="121153" checksum="5DEC09F5B6704DB5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH80</accession>
    <name>F9XH80_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_95071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003850390.1"/>
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    <dbReference type="OrthoDB" id="2162449at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:CTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="PRK00668.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
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        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="88"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="16847" checksum="E44E7E6095A625A7" modified="2011-10-19" version="1">MSSSEQTFIAIKPDGVQRGLVGDIICRFEKRGFKLVAIKLVTASKEHLEKHYADLAEKPFFKGLVSYMGSGPICAMVWEGRDAVKTGRVLLGATNPAASSPGTIRGDYAIDVGRNVCHGSDAVESAQKEIALWFEKSEIQSWKSAQHDWVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI10</accession>
    <name>F9XI10_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_74868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850071.1">
        <property type="nucleotide sequence ID" value="XM_003850023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI10"/>
    <dbReference type="GeneID" id="13394272"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74868"/>
    <dbReference type="eggNOG" id="ENOG502SJVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033830_1_0_1"/>
    <dbReference type="InParanoid" id="F9XI10"/>
    <dbReference type="OMA" id="WWIFTTA"/>
    <dbReference type="OrthoDB" id="5420247at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="36931" checksum="3F21D29B54BF6909" modified="2011-10-19" version="1">MTLDVSKPATVDGVMIEAWAQGFMCGSLIVMACVAIANMRKRTLLHKLIVIELLFGTFHGTFIFTNPPVYNWYLSVTAIFLNISWSLHNLIAWIKNKPFLGKKASRFYIGTVILVQPYWVLEITANFLYFSGRSDLFRYTRPYEALFRDPWWIFTTVNLLWNIKSRYEFGYGELIRVSPRFGIMLGAMLMSLAFIIVDILAVTRVIPTSGLPNGINPFWKLAFVFKCLSDTMVLDDFKTALDRLKQYKMERMGSVLSDGLRGEFVDVEAARKQKAEGQLQPLPVDSVHVRDWSCPIKGSDAEFLDLESALRIGPGPRGESSGSSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI25</accession>
    <name>F9XI25_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850526.1">
        <property type="nucleotide sequence ID" value="XM_003850478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI25"/>
    <dbReference type="GeneID" id="13395179"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94910"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.55"/>
    <dbReference type="HOGENOM" id="CLU_1157194_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI25"/>
    <dbReference type="OrthoDB" id="10294450at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="240" mass="27360" checksum="2FAB3593F5BD3A4A" modified="2011-10-19" version="1">MSTSEHNNIRPRSRSPPNDFSDVPRQKFAIGDHVKFVVHDTAKQDTTEQDNPKQDAAEQKTVEHDISEHNAAVQGTEEVRIQLSEVDLSEKPSAASTLLRSCQALKLHLRRLIDLDDRYRAIENPWHGPSNPMILGWAVQTRYHVQSVLTTLDQHIGSSLRDNEVDHFTFYPRESELTTLIRAIERLEVQPDRLVGLEQVESAPWTTVVLSQLQRQLEGLTVRLLDHMGPVGGRDGQREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI27</accession>
    <name>F9XI27_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_94912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850524.1">
        <property type="nucleotide sequence ID" value="XM_003850476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI27"/>
    <dbReference type="STRING" id="336722.F9XI27"/>
    <dbReference type="GeneID" id="13395177"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94912"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.57"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045160_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI27"/>
    <dbReference type="OMA" id="HAIHRNA"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="370" mass="41133" checksum="4BAA5AA33122BC8E" modified="2011-10-19" version="1">MSTHANIVGATTAAQLASTTEAQSFDFIESDNFTWMEGFDGATEGEVQVLESQQSEKLYVCKHTFSHPTKNVNDMKDGDTATHRYPVEARILLKHLKPHPCIISLLACTADPDERGRYKLWMQYCSGGDLIGQAWASKNRRLVIPEQFVLQVAIQISEALAYLHHGLRHVGEGKYTQDAGHEAVIHGDVKGDNIFLRWQKSADRIGNMPDVVLGDFGAAKLASDRNIMTGMGTPGYHSPEDRAVYGNRDWNDPSNRHVFIEMISRRTTGADIYAFGQVMYQLATKDDKCWPIGQDPASLEISAEYSTPGLRNFIVSCLAVDPRRRGEASFAPGTGFLPAVQRLRDARADLVQSRRAPSRLEWDKPPKLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI29</accession>
    <name>F9XI29_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_74379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="VYRLWLY"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="343" mass="39295" checksum="0665829496AFB14D" modified="2011-10-19" version="1">MFFDTLPNEILGHIYLSLPDISSVIALSSTSHRFHSAYHSSKKLEILQDAADAEFGPLEDIVQLLTQNASQPAHIRREVPMSEALLHQILKVGRVAQKYEEIYPFKKWKTDFANRRLLSTSERYTLRQALYRLWLFDKTFHTSSHVRTCRGMPSIVRERASLLHNFSTTELAAMLDVHAVLRDMVANNICPSNGRIRQKFQKRYPESNQQLLFNIHLNYPPAPSSFVGEGWSTFGAGRYQSRLAPTRWHEPGAEGWGDDISHYYIIEDMMKLDPEQLLYLRDNCHLKAQVESHVRGLGEWFVNNGETFSETLGFVIKQRGGDVEDLKVAVEEGEVGVALVEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XI46"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46813"/>
    <dbReference type="eggNOG" id="ENOG502SI2I">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5404564at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="680" mass="75803" checksum="4396573501BD0B64" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIS0</accession>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="OrthoDB" id="2119228at2759"/>
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    </dbReference>
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        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SGNH hydrolase"/>
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        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
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        <location>
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            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="488" mass="53578" checksum="7CA2861D9B8C7AF9" modified="2011-10-19" version="1">MGDAADSSSSKPLRIMIVGDSITHGSEGDYTWRYRIWEWFQTAASSQPITFVGPYIGTGPADEYKPPQPPRFPDEPEPPPRDCTTGGYNESIHASFQREHFAHTGRAVFQAKDAIHEQVTNLNPDLLLVLLGFNDMGWGFSDHIGTLENTLAFIANARLAKPDISIALSNVPQRSPIPGREDLVDWTTKYNNLLKHAIKADRLDHLSKFSRLELVDVASVYGWSPDECAGAFDGLHPNELGEFQIASAFSTVLHKSFNIGTAPLSIPRSSKIPKRPLHTPTNPACTGVPWGIHFSWDPVYGSRGYDVRSRCAGQEEWEESHHGECGIDNTFTPAGQEWEFQVRAKVGVEEKDKSDWSAIAKGTATRSTAPPPENREVFSRGKDGIEVTFTPLPNDSKFEVERYAVNWVDETAGGFLGGQGVRLEDGGRCVVQGLEVGHRYQVWISTWTKREGGGVFGGAGKVVVGSGVFSRPEGLSGDLERLSLEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIU7</accession>
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        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
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    <gene>
        <name evidence="14" type="primary">IDI1</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849415.1">
        <property type="nucleotide sequence ID" value="XM_003849367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIU7"/>
    <dbReference type="FunCoup" id="F9XIU7">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIU7"/>
    <dbReference type="GeneID" id="13402482"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62428"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_0_2_1"/>
    <dbReference type="InParanoid" id="F9XIU7"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="30173" checksum="7C6E0BE6B57662BD" modified="2011-10-19" version="1">MSSTMTVTETEPTYTERILQLFPEINTSLATQNRSATQDQDLAGYDEEQIRLMDEVCIVLDKDDAPIGSASKKVCHLMENINKGLLHRAFSVFLFDSQDRLLLQQRASEKITFPDLWTNTCCSHPLGIPGETGATLEAAVAGVKRAAQRKLDQELGIKKEQVPIEKFDFLTRIHYLAPSDGKWGEHEIDYILFIKADVDLNINPNEVQATKYVSADELKDMFKDDSLKFTPWFKLICQSMLFEWWQNLNGGLDKYKGETEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ74</accession>
    <name>F9XJ74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_75370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849321.1">
        <property type="nucleotide sequence ID" value="XM_003849273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ74"/>
    <dbReference type="STRING" id="336722.F9XJ74"/>
    <dbReference type="GeneID" id="13402585"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75370"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.148"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001116_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ74"/>
    <dbReference type="OMA" id="PNHYMGL"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="549"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130835" checksum="DBD198072D75B0C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJC0</accession>
    <name>F9XJC0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_62534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849450.1">
        <property type="nucleotide sequence ID" value="XM_003849402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJC0"/>
    <dbReference type="FunCoup" id="F9XJC0">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJC0"/>
    <dbReference type="GeneID" id="13402452"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62534"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.413"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_2_1"/>
    <dbReference type="InParanoid" id="F9XJC0"/>
    <dbReference type="OMA" id="EYVAFEV"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="94" mass="10616" checksum="837F5D320EC82BC2" modified="2011-10-19" version="1">MKVTAALFGRRSVWKGPHIVPLPIIRAKAGERTPPVKTQARSATILPNFVGLVFQVHNGKIYNDVRITEDMVGHKLGEFSATRKRFTYKQTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK15</accession>
    <name>F9XK15_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_87598</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849500.1">
        <property type="nucleotide sequence ID" value="XM_003849452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK15"/>
    <dbReference type="FunCoup" id="F9XK15">
        <property type="interactions" value="1191"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK15"/>
    <dbReference type="GeneID" id="13402414"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87598"/>
    <dbReference type="eggNOG" id="KOG2268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK15"/>
    <dbReference type="OMA" id="MIHHENT"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="72"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="272"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="410" mass="46223" checksum="4E4D863CCD866D2E" modified="2011-10-19" version="1">MKLDTAALRYLNDDDWRVLAAVEQGSKNHEVVPTPLIASIAHLRGGNDGYRLTYGGFDYLSLNNHRRSNTIFSVGNQIGVGKEADVYITASPDGEQMALKLHRLGRISFRTVKANRDYLRNRHAGSWMYLSQLAAQKEYSFMVVLHREGFPVPRPIAWSRHTVVMEFIDSFPLRGIESIPDPGKLYAELMDMIVQLAKRGLIHGDFNEFNILIKEKTIGEKIELQPVLIDFPQTVSTNHANAQWYFDRDVECIRRYFERKFKYTSDARGPSFKDAVKGADPAKRLDVESTGGIKSEADADVDDDEDDDDEEEEEDDDDEDDEFEEVAENNADAPDGEDGKVQPGLEQKEAASVDDADLVKDVEVLTVEDDTEGKQLMPEKFGFQPMDLPREADVAAEKVRSKKKASGWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKB0</accession>
    <name>F9XKB0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849405.1">
        <property type="nucleotide sequence ID" value="XM_003849357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKB0"/>
    <dbReference type="GeneID" id="13399101"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95743"/>
    <dbReference type="HOGENOM" id="CLU_1200641_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKB0"/>
    <dbReference type="OrthoDB" id="3650810at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="231" mass="26645" checksum="11F05F9041C344FC" modified="2011-10-19" version="1">MAHNFSTVSAGPHHEDYSYMLYATRQTVTDLSDGSSYLETAISCFHEEERCRHPEKDTRRGVHRTKTTKASIPPTSADPSTIALRAHLESLPQELYDDIYNLTFTVDSICRGKDQITQQDLQILQVNRATRHRLLPDFFAGGLKTEYNVSMSKPDPKFPLWIMEFPDFHKPLIDNFECHCEYEASIFAWRASTETHRKTREKEIMKVLLHRGFCVKDGGWQGCVRAVFLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKE5</accession>
    <name>F9XKE5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_87635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849576.1">
        <property type="nucleotide sequence ID" value="XM_003849528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKE5"/>
    <dbReference type="FunCoup" id="F9XKE5">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKE5"/>
    <dbReference type="GeneID" id="13402373"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87635"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.583"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="InParanoid" id="F9XKE5"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="217" mass="24678" checksum="812BB44BAC31CEC9" modified="2011-10-19" version="1">MAVKTSPSPARSFRTAYLTLYNISFALLWSFVFVKTVRNIPHGRHAVFASTEPLARWVQTLTLVEVVHSVVGLIPSPLGTTFTQVATRIIQVWLIWRTFPETTASSLVFSSLLLAWSIADTVRYGYLAANLHGKAPKWLVWLRYSLFIPLYPIGIGAEWWLMFQAAKPVGEIHAILPYVFYFLLALYIPGSYVMFTYMLKQRKKTLARSSKNARSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP8</accession>
    <name>F9XKP8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GTG2401</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_76263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849144.1">
        <property type="nucleotide sequence ID" value="XM_003849096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKP8"/>
    <dbReference type="FunCoup" id="F9XKP8">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKP8"/>
    <dbReference type="GeneID" id="13398023"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76263"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.240"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKP8"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="12760" checksum="EC2B95510FB953FB" modified="2011-10-19" version="1">MSALPRSLRACLICSFVQPHSRFIKNGCPNCEHFLEMRNSSDVVAECTSEVFEGVMEVNDTNTSWVAKWQRLEGYVPGMYAVKVNGVLSDDYIVAAESAGVTYMPRDGSQSTDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL06</accession>
    <name>F9XL06_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spo7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_62869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849218.1">
        <property type="nucleotide sequence ID" value="XM_003849170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL06"/>
    <dbReference type="FunCoup" id="F9XL06">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XL06"/>
    <dbReference type="GeneID" id="13398765"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62869"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032659_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL06"/>
    <dbReference type="OMA" id="EYKRTIV"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33879" checksum="DFC3DB0CBEC8783C" modified="2011-10-19" version="1" fragment="single">MSDPIDRIVKGAPPPDVSAEQLAANARATGPSQAHSITAPLPPLHQGHSSDPRDALPSSPPQIYLNLLILESSLRLQYVSLRARLRLHLLLLVTLVLWVLGFTYLLFFRPREDGSGVGGSVYWVVESGEKLGWASGIVTLTLFWGTGMYERGVRWPRKFVSTTNRGLRGFNLKVVVVKGSFLSELAGWVAMLDQLGWFREDRVNYQIMPKDIELGGGKVENWNMHAARHGLLEEDIAPGGDVLRVLLLPKPFSPDFREGWDTFRMEYWERENARRSQLRTVVRARKREVAKRDGGWIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL99</accession>
    <name>F9XL99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_101365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849201.1">
        <property type="nucleotide sequence ID" value="XM_003849153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL99"/>
    <dbReference type="STRING" id="336722.F9XL99"/>
    <dbReference type="GeneID" id="13396626"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101365"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.120"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="InParanoid" id="F9XL99"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395552" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="363" mass="39042" checksum="CF7501514871FEB8" modified="2011-10-19" version="1">MLRFTQLFTAALVVVSTSAAAVVDLTPSNFDSIVLKSGKPALVEFFAPWCGHCKTLAPIYEELAGSFASSTDKITIAKVDADEHKSLGTKYGIKGFPTIKYFDGSGKSEPEDYKKGRDIDSLTEFITEKIGVKPKGAKKVASSVEMLNDSTFDKQIGGDMDAIVAFTAPWCGHCKSLAPIWETVAADFASEPSVLIAKVDADAPNGKKTAERYEVRSYPTILYFPKGSKDAVPYTGGRTEADLVTFMNEKAGTFRSPGGGLNALAGVIPSLDEAVAALKTGGEKAYKELAKQAGALQDKTAEYYAKVASKAENNAGYLEKEYTRLQNLIGKGNLAPEKLDDLISRKNILSRFIGQEDDAKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLN1</accession>
    <name>F9XLN1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848831.1">
        <property type="nucleotide sequence ID" value="XM_003848783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLN1"/>
    <dbReference type="STRING" id="336722.F9XLN1"/>
    <dbReference type="GeneID" id="13398633"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105909"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_3_2_1"/>
    <dbReference type="InParanoid" id="F9XLN1"/>
    <dbReference type="OMA" id="AKWVIHT"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="178" mass="18861" checksum="ADCA5A6556C0D79D" modified="2011-10-19" version="1" fragment="single">MSPTPLSDILPLSMLYKTENLAPSSTPLETSTSRFNDKISIVRTDITTLEVGAIVNAANESLLGGGGVDGAIHSAAGPELLRECETLDGCDTGDAKITDAYDLPCSKVIHAVGPVYFRTKREGTHTSLLQSCYTRSLDLAVDNGCKSIAFSALSTGVYGYPSMEAAETAIQAVKQWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLQ9</accession>
    <name>F9XLQ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_111104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849071.1">
        <property type="nucleotide sequence ID" value="XM_003849023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLQ9"/>
    <dbReference type="FunCoup" id="F9XLQ9">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLQ9"/>
    <dbReference type="GeneID" id="13398468"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111104"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="InParanoid" id="F9XLQ9"/>
    <dbReference type="OMA" id="WSYPPSA"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="483" mass="53814" checksum="5B9EF4BE5C6D9C99" modified="2011-10-19" version="1">MLNRALTRHGNGVLFSSTLSRNGILRAHRQLLLSRPHSRSIETTTVTSADIARLAAAPLHPLTLADLCKHGRSPLSESALLNSANFTLDILPARLAHRIQSLRALPYIVVANPNVSRIHSNYLHSLSTLLPYAERRIESLEDEIKFTEVMADLVRTHNNTIAVLARGFLEARKYITKEAITAFLDEHLRARIGTRLIAEQHIALHFSSIPHNRNPPQPSSYIGVIDTSLRPADIIRSCEHTVGEICELKYGVRPTVNIIGSPDTTIAHIPMHLEYILTELLKNSFRATIEAGMEREPVEITIAPAPASASQTADLKSKSSSPNRTSSAITNQDQGSVDLASGGKSSNDSTIRPLAQQTPGVTIRLRDRGGGIDPAIHAKLWERKTKAWRSKRDSAFPALLHPDRGKELLLYPAHHLRADELKEYIRLAELQIRPRLAMLIKRWPIRPISRRRRQVRTSPKVIDELGWRIPNPDDDAAGAVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMM5</accession>
    <name>F9XMM5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_87952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848700.1">
        <property type="nucleotide sequence ID" value="XM_003848652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMM5"/>
    <dbReference type="FunCoup" id="F9XMM5">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMM5"/>
    <dbReference type="GeneID" id="13396558"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87952"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.95"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="InParanoid" id="F9XMM5"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26912" checksum="882B1ABBE4BC1366" modified="2011-10-19" version="1">MLPTPTTSHVSFDRIYEPSEDSYLLLDTLSSPSESTFLSTHFPTSTPPPLLLEVGTGSGVVLAFALAHAQRIFGRIDLAALGTDVNIFACSATAQTATLARQENLKTAGSWLDAAQADLTTPLRAGCVDVLIFNPPYVPTDSLPNAEFSAAAGEGEFERDSHLLSLSYAGGKDGMETTDRLLEQIPEVLSRRGVAYVLLCAQNRPEVVMERVRAWEEGRGGWRAEKVGVSGMKAGWEKLCVVRIWRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMS3</accession>
    <name>F9XMS3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848319.1">
        <property type="nucleotide sequence ID" value="XM_003848271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMS3"/>
    <dbReference type="STRING" id="336722.F9XMS3"/>
    <dbReference type="GeneID" id="13396120"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106098"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="InParanoid" id="F9XMS3"/>
    <dbReference type="OMA" id="KGVGHWH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="23089" checksum="43DAB2335CB3539E" modified="2011-10-19" version="1" fragment="single">MPFATVKSHRIHYVESSELGYENDSSKATIVMVHGLGSSQNFYVPTFPSLAGHRCIALSTYGAAQSKSNGEKLTLEELADDVIGLMDHLKVERAILAGHSMGGPMVLTVAARHPERVLGVVPIGPVNPSSIKPEMFTSRIETVLKDGMEPLANTVPKAATNANSTGVQRAMIRELIIGQDPKSYASHCEVIVNVKDPGFGSIKVPVLLIAGDEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN88</accession>
    <name>F9XN88_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_82615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848581.1">
        <property type="nucleotide sequence ID" value="XM_003848533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN88"/>
    <dbReference type="STRING" id="336722.F9XN88"/>
    <dbReference type="GeneID" id="13396502"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82615"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052897_0_2_1"/>
    <dbReference type="InParanoid" id="F9XN88"/>
    <dbReference type="OMA" id="MISECIA"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="154" mass="15518" checksum="8CE4D78422FCAB91" modified="2011-10-19" version="1" fragment="single">MIKEAIISLKERSGSSRQALKKYVQANNSHLAGVTDASFTSNFNKALTKGAETGVFDRPKGPSGPVKLAGGAKKAAEPKPKTAKAPAAAKKATTAAKPAAAKKTTAAKKAPAAKKTAAAKKAPAAKKTATKTATKSKANTSKVRKTPAAAPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNA4</accession>
    <name>F9XNA4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_111297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848403.1">
        <property type="nucleotide sequence ID" value="XM_003848355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNA4"/>
    <dbReference type="GeneID" id="13396497"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111297"/>
    <dbReference type="eggNOG" id="ENOG502RYJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_2_0_1"/>
    <dbReference type="InParanoid" id="F9XNA4"/>
    <dbReference type="OMA" id="GTDHKRH"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37833" checksum="C6D1EC925A6C8611" modified="2011-10-19" version="1">MSAFNTPWFNSQDRSFFNVLNKSKIAHVVLAAETEDFDEETEQQWKDEGFHVQYVPLLKGGDDFINRIHTTGDTFGVSEQYAIVAYGDAASLALEAHTKPNHPKLVAIVAYYPTTIPAVTTKFPFSIQVLVHLAGNEVNVWKQGEVLGIQGKRRRLQKRIDPGIGYGECLKLSYKAYTYTGVQPGFAEHDLDEYDPIADGIAFTRSIACVRKGFRVDNDIEAVRDHHARYMYSGQTDRTMAQVRSYGHVLHTPTLVGGVGSEDLEYFYSELFTPIPANSNTQIRLLSRTIGTDRVVDELFVSLAHSIEIDWLLPGIPPTNRKIEIVIVSIFHCRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNT7</accession>
    <name>F9XNT7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor methyltransferase 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_111491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848135.1">
        <property type="nucleotide sequence ID" value="XM_003848087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNT7"/>
    <dbReference type="FunCoup" id="F9XNT7">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNT7"/>
    <dbReference type="GeneID" id="13401637"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111491"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="InParanoid" id="F9XNT7"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32575" checksum="4AEAC690F4B3D477" modified="2011-10-19" version="1">MALDEPELDHDGFALAEDLVQSPTHKAASTTTVDFDGLLDPGLLLHEDLAKGNGGQAWPAGVILTKYLLRRKREELRTASILAVAKACSPASPVYITDQGSMLALMQRNIALNDLAKNVKACVYDWGQAQPDDIPQTPPDVVLAADCVYFEPAFPLLQQTLQELLGPSTVCYFCFKRRRRADMHFMKAIKKKFLVEDIIDDPDQPSYSRENIYLSECSSKLVYPALRPVKLPPIVSARVTSSKRIPTTSTYTSTRLGERLNGDECAPSSPKCNNPASQVLGKAVHFDAALGRGDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP20</accession>
    <name>F9XP20_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_77548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848094.1">
        <property type="nucleotide sequence ID" value="XM_003848046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP20"/>
    <dbReference type="GeneID" id="13401950"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77548"/>
    <dbReference type="eggNOG" id="ENOG502SS5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099515_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP20"/>
    <dbReference type="OMA" id="MMFPPVL"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14811" checksum="14F71EE7DA870ED2" modified="2011-10-19" version="1">MPMPSKAPDAEEAKQSLFSYAKAWGENPLPPTLLATLITAQHFRPFQTLPMLFPPVLLFSSYLNVQGFKKDSAGMMSAWSLAYFVLARRRHQPLRQKFGVRGVVRGATVGLCAVNALAGGWTYWTAKKADVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP93</accession>
    <name>F9XP93_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_50274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848034.1">
        <property type="nucleotide sequence ID" value="XM_003847986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP93"/>
    <dbReference type="FunCoup" id="F9XP93">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP93"/>
    <dbReference type="GeneID" id="13402065"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50274"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.419"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_1_2_1"/>
    <dbReference type="InParanoid" id="F9XP93"/>
    <dbReference type="OMA" id="HIQTTYA"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="206" mass="23865" checksum="3875FAC60D7D66A4" modified="2011-10-19" version="1">MAGGLVKYRHLSRDSAHRKALLRNLVTSLIKHESIQTTWPKAKEAQRLAEKLITLAKKNTEASRTRAQSIFFTPHDLLPKLFGPLRDRYLTRPGGYTRVLRIEPTKEDQAPSALLELVDGPKDMRMALTARTIANLRAKAEERGEEDVRINDMTLHNVRKVTRFRENGEEELEELVKRFERLNDEGDEGVEVVRKKRVYPKQERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPN7</accession>
    <name>F9XPN7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_64493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847819.1">
        <property type="nucleotide sequence ID" value="XM_003847771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPN7"/>
    <dbReference type="STRING" id="336722.F9XPN7"/>
    <dbReference type="GeneID" id="13400818"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64493"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_2_1"/>
    <dbReference type="InParanoid" id="F9XPN7"/>
    <dbReference type="OMA" id="VISCFAT"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="217" mass="22748" checksum="1B97BF7FB869275F" modified="2011-10-19" version="1" fragment="single">MTGYHKVAVAGATGNLGPAVVEQLVKADLSVTILSQSGNTSSLPSSVKTVKVDYKSPSSLKSALAGHEVVVSLLPDHGSQPALIDAAIAAGAKLFIPSEFGADLDNAKAAALPVFAGKAVTRNYLRDRTDQISHTLVVCNIFLDWGLQVGFLAKLREEMGPTPLYDGGETKRSATLLSDVGKAVVSIIADPEAAKNRTVRIQSTALSQKTILRIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPV5</accession>
    <name>F9XPV5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847557.1">
        <property type="nucleotide sequence ID" value="XM_003847509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPV5"/>
    <dbReference type="GeneID" id="13401449"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97329"/>
    <dbReference type="HOGENOM" id="CLU_534435_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPV5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="510" mass="55320" checksum="54DC8BF8944509D6" modified="2011-10-19" version="1">MLEQWEHHDHDSGHGPMTASSNREADSCYAVQVSRAQATPPAERPRRCNENNSPQISASIPTAEHTAENDYLDIRMALHYARAPPTATREAADDGVDSMILLTDASIPKDKQHRASRGTQKGLTHGARGPHPAAACTPDLRSKQPEREGTAALAGRQRYKTSEDVSLYACSRVSEVHRPWPKRTSVEADGSGILQDGIARVGAVAHQTSSSLAITQSPEGVAREWSCSMPIRAKRDHHLIARTRPSIRSKETALEVYLERSLQIPDRGKSKPPAQKPVKTPPAANSKARGRKGYHATPLTLPGARTSNGGAWSQSEVLSSPLRVQTIPIASREQADHDRVGDWPHSSSQRFLNANILHKMRREFLPVRGELITSQNVLEAGAGSVGTTLRGAALAEAVIAVSAWGVPRSPFESFVARSLSHRPCAHNRANYGVEPVICLCNDELTGGVGGGVSCVWAAWRKRTAAAWDTEHCVCRLRRDDCDWAESVSVCLSAGCGSTEAASRDGFVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPX3</accession>
    <name>F9XPX3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97342</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPX3"/>
    <dbReference type="GeneID" id="13400790"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97342"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.139"/>
    <dbReference type="eggNOG" id="ENOG502RXHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9XPX3"/>
    <dbReference type="OMA" id="QPNYPQG"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="644"/>
        </location>
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            <begin position="735"/>
            <end position="763"/>
        </location>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Dehal P."/>
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        </source>
    </evidence>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97477"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.302"/>
    <dbReference type="HOGENOM" id="CLU_1476270_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQC0"/>
    <dbReference type="OMA" id="QYGAVEQ"/>
    <dbReference type="OrthoDB" id="4168609at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="183" mass="20243" checksum="756660DFD9740181" modified="2011-10-19" version="1">MLSRLKTILTSSTPAKHASVALLIASPPSPGKPSMGLDILHIVPETGTREPPGCGIYAEDAFRRCRVVETKREHLGSITFAEGLGDSSYFFFQELADTAREMLQKEASEGVKGTLKRAPVPVDLLERVLRTVAMDGMFERNARKPSPEVVSVTYPIFVVHVERPRAGELFTIKERQRFLSTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQH9</accession>
    <name>F9XQH9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847671.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQH9"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97526"/>
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    <dbReference type="HOGENOM" id="CLU_1338476_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQH9"/>
    <dbReference type="OrthoDB" id="3631261at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395735" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22041" checksum="C882D780EC3E6236" modified="2011-10-19" version="1">MLNHHRFHALVVLGAVLQLPFAVMAEVPTCDPLPDHANYSGDHGLDKNGAWCPYDDSHFQKPLGVGCQRDSECQRGPNHRSIYPYTNGKDWMSINYDVILTQGTGICDTDHQGGTVCNAVIPPIDAHPGGPAQPAVAPGSDPKSTCREILSKGGDTGIGIANGCWIPYEGTRVLQCMLTCNNSPSCSPGDDPNEVHKYLDQFPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQU7</accession>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQU7"/>
    <dbReference type="STRING" id="336722.F9XQU7"/>
    <dbReference type="GeneID" id="13400363"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51578"/>
    <dbReference type="HOGENOM" id="CLU_056788_14_6_1"/>
    <dbReference type="InParanoid" id="F9XQU7"/>
    <dbReference type="OMA" id="NQRCEIW"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="52" mass="5803" checksum="887A391A7E3A8720" modified="2011-10-19" version="1" fragment="single">SPGSIIVIDNASIHRHKEVSVVVANTLCFLEYLLPYSPDFNLIEQSFNVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQZ7</accession>
    <name>F9XQZ7_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_97683</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847340.1">
        <property type="nucleotide sequence ID" value="XM_003847292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQZ7"/>
    <dbReference type="GeneID" id="13400333"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97683"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.75"/>
    <dbReference type="HOGENOM" id="CLU_811848_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQZ7"/>
    <dbReference type="OrthoDB" id="10406865at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="342" mass="39121" checksum="047879463E13C220" modified="2011-10-19" version="1">MEPTYGTTKLTMADLLSRDKRGHRLKQHALKLDDTCLDYLDDRCKEDSFDRYHMPKAHEFLHLLAGMYLFYDLKSKAEAVELAYRTGSIMVARHKGKKDKDHPRQAEKKDLEALAEEVGELWEEEKDKAKGKREEKEKAKREREEAEEKAGEEEEEGDSAIEESATEESDIEGSDIGEPDMEEPDIEESAIDKKSEMIDELQFPPPRSATPKPKTKMEAKSTPRAPKSGLSSCPPDIRLTSPLTTISSQVPHHPHTTTTTTTARPIHTLTHDLQVKYNKQKLIQLNAEWNKLNIELTKVNKKSNNLKQKCEAMMASIAEKQAREVELKKEVRKMQKEVDMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR64</accession>
    <name>F9XR64_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847288.1">
        <property type="nucleotide sequence ID" value="XM_003847240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR64"/>
    <dbReference type="GeneID" id="13400093"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97724"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.34"/>
    <dbReference type="eggNOG" id="ENOG502RFRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1284181_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR64"/>
    <dbReference type="OMA" id="HAINAFT"/>
    <dbReference type="OrthoDB" id="3631417at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25294" checksum="19D0E2D849F3DCA9" modified="2011-10-19" version="1">MATTNNAMQSTFQTPELLEQILLQVDDLRTLLPSQRVSQQFLQTIQGSKRLQEELFFRVKWPAPQTADDSEIEVNPINPLLLSQKHRIGIHSVDIEVQHYRKNKLNFFGFLDIHLIFDPIDHMKELEESDWEGSWRKMLIVQPRSIKYDRWQLSHQFAAGSRWTTSAGRGRWHDAYTMDGLVRELLERVEELKAWPWGDCDTNVRPADADTWEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRJ3</accession>
    <name>F9XRJ3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847171.1">
        <property type="nucleotide sequence ID" value="XM_003847123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRJ3"/>
    <dbReference type="GeneID" id="13399686"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97839"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.77"/>
    <dbReference type="HOGENOM" id="CLU_1705650_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRJ3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="154" mass="17633" checksum="D335B841050CA2F5" modified="2011-10-19" version="1">MLHGCRLHPATDHRLSSVLGVIQDRLDLPFELDVTKLKTDCLGRSTLNPETGCTANPRGRTHTFIGATRLKVSASTNKTPAKALAYFHKQIRDHSFFEKFKEDFKELEEARRDVHDRYKSDDPAIMSKHALRWCNAYSGDWVKNANTAQHVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRT1</accession>
    <name>F9XRT1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846993.1">
        <property type="nucleotide sequence ID" value="XM_003846945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRT1"/>
    <dbReference type="GeneID" id="13399238"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97925"/>
    <dbReference type="HOGENOM" id="CLU_1210628_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRT1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="229" mass="25869" checksum="4AAA4205DBCB292C" modified="2011-10-19" version="1">MTRWTEVFPDLGASIRFWAETNQVSKECWPLRARHHLWHCYPVRMPARRDEFVQDDEEETRPVKKSAPVNDSTLARGSRRVSPRHFIKAKLAAIAKKNVLRITDSRVADIVAESNRNVIHPADTAMQHLLMLHHHAKAINNTELTTRADDFSQSGASDFSHTEQADSASSHNCQAGTAPEERRKGLFAPVQGQCGAHRCAWSAGPVQQRRHLLDRSWDAWDLALGVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRX9</accession>
    <name>F9XRX9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847021.1">
        <property type="nucleotide sequence ID" value="XM_003846973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRX9"/>
    <dbReference type="STRING" id="336722.F9XRX9"/>
    <dbReference type="GeneID" id="13399205"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97972"/>
    <dbReference type="HOGENOM" id="CLU_1190689_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRX9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="233" mass="26334" checksum="E6BEF5595B953630" modified="2011-10-19" version="1">MSSEDDLRSFIRTWDDGNGSATDDDDDFERSTNRHRLRSTANLTKDDIQELGLPDDHNDGSSAIKSKDESPKDKSRIRVRRMMEEKIDPTKMTKIEWTSVWAAYTEAWTDPEFEFVLEHTSPKAPKGMENLLPRQPIPHPWKSPAALVEAAAEYRDLFGYTPPAEKKKTLQKTTTAQVTAALAEKNKQKLAQANSVQKTHTVPIQSKTLLTKKNKQTHYLTPAPAAKKGVDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW74</accession>
    <name>F9WW74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_98231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857664.1">
        <property type="nucleotide sequence ID" value="XM_003857616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW74"/>
    <dbReference type="FunCoup" id="F9WW74">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WW74"/>
    <dbReference type="GeneID" id="13403235"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98231"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="InParanoid" id="F9WW74"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="433" mass="47522" checksum="0FA78BA0E6248365" modified="2011-10-19" version="1">MSVTPWICSRCLRSLARPIKGQLRLRRRYQSTAAASTANDNLSSALLSRARNVASEHATLTQKLATDFDASAAKRLGELTRTANAIQEYDKAKSALEELHGLLKSSDLELKELAEEDIQPTQEKIQQASAALKHSLIPVHPFAHLPCLIEIRPGAGGDEAALFAGDLLRMYTNYCARNELNTTLLKLETADYSAAGGTSSSGSTHVQEAVLEVHTPGAYGILRCEAGVHRVQRVPATEKQGRTHTSAASVLVLPSLGEDPGGDMGEDSFNDPKSDYYVDPKEVRMDVMRASGAGGQHVNKTESAVRLTHEPSGIVVAIQETRSQIKNREKAWRLLRSRIAQIRREEREAELVRLRRGAGAGKVGRENKVRTYNWGQQRVSDHRSGIDSRHLDDVIEGGEALETVMDSVRAWMTEEEVLGLIAEEEASMKSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX51</accession>
    <name>F9WX51_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856979.1">
        <property type="nucleotide sequence ID" value="XM_003856931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX51"/>
    <dbReference type="GeneID" id="13398690"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90089"/>
    <dbReference type="HOGENOM" id="CLU_1391226_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX51"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389741" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="196" mass="20970" checksum="1BB254BEF14F575C" modified="2011-10-19" version="1">MKITALLFLAAADVVLGNAVWCDGATAPEANNICWQINGRVALALKVPVTTAAVAIFVARSRAPSAGARTTDAKPLHISTVKSTYPNGKPLQRSTLIGGHNATVKEVLRSCASSNHLKRTVARWLIVVGGAVSATGFAAESNVMRPKKGNTQKVVELLKEAAAHVEKDEKDTTRYEIYSSLRTAKDGTDQIFMVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX79</accession>
    <name>F9WX79_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_31528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003856753.1"/>
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        <property type="interactions" value="824"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31528"/>
    <dbReference type="eggNOG" id="ENOG502RVD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007548_2_0_1"/>
    <dbReference type="InParanoid" id="F9WX79"/>
    <dbReference type="OMA" id="WPVLHEK"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="613" mass="70079" checksum="BE3B73E7200E16CE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXB8</accession>
    <name>F9WXB8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="10">26S proteasome regulatory complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CSN5</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_51814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855786.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="MEROPS" id="M67.A11"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51814"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.9"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXB8"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902906">
        <property type="term" value="P:proteasome storage granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="354" mass="38392" checksum="46F744B0CDEC2BB6" modified="2011-10-19" version="1">MDRLSRMLAAAQGMGGGGGGPAQDTNIIDNAETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVIDPIQSVKGKVVIDAFRLINPQTLMLGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIGIGYRKTALEEGMLMNLHKTVWTEALTMPDFAAEGCRNGANLKKLVSLAEGYEKRVKEETELTKEQLRTRYVGKVDPKKHIETVGQELIEDNIVGVTRQMIDKEASVPGAAGEGLGSGRGVNGKGTNGKANGHAGADQSAMEVDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXU4</accession>
    <name>F9WXU4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_52546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856112.1">
        <property type="nucleotide sequence ID" value="XM_003856064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXU4"/>
    <dbReference type="GeneID" id="13403105"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52546"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="InParanoid" id="F9WXU4"/>
    <dbReference type="OMA" id="APLMDYW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="484" mass="53223" checksum="98F56E1176721055" modified="2011-10-19" version="1">MPDFPKEHEPTVLSSQIPSEDFLVRFAEGDSDDPRQWNRRTKWAATLTLSAQGFNRIMISTIMAPGIPAIATDLSMTTLDATMALSAYVLATAFGPLVIGPLSEVYGRKNVIHITNIWFLAWNLVCGFANSKGLLIASRLLAGFGASAVYTVAYGVLADIWPNEQRGRSLSLYLLIPLTGAAIGPIVGGFIVEYTTWRWMFWSTTIFQAVAEIVTLPIVYETYAPLLLHRKAEKLRKHTGDLRYHTAAEMTNDHSVMGVLAMSLTRPLRLLMFHPIIQIQAVLGGLNYGLLYFALASFSHLFVNQYHQPVSISSLHYIALATGEVAGAQFCGPSMDYLYKILTRRAGGQSSPELRIPLLIPSALRTPMGFLLYGWAAHFRLPWIVVDIGAAILTMGMQVFTTVLRAYVMDSYPEHVSSASAATQFLSSMLAFAFPLFADSMYAALGYGWGNSLLAFLSLGISVPSSLILWNFGARLRAKNDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYB4</accession>
    <name>F9WYB4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856537.1">
        <property type="nucleotide sequence ID" value="XM_003856489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYB4"/>
    <dbReference type="GeneID" id="13399004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107483"/>
    <dbReference type="eggNOG" id="ENOG502SJVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507009_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYB4"/>
    <dbReference type="OrthoDB" id="5396360at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="179" mass="20164" checksum="C1419C34EEA4BEE7" modified="2011-10-19" version="1" fragment="single">MMEKATSRSARSRTASMTATDMAIREPSRSVPQPQQHPQPPHSHHHGHTRHPSLGGSNGVDRMPTDIWTSAISRLQAQVSYNTGMLESHRRQFADMEMAVNRLNQELGSVAGTLNEVRNEVRSRQLGPSDRSRHDSGDLEIISGQLQRLTNRVNEVDGLNMQMDLIKNRLKRMEDHTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYC6</accession>
    <name>F9WYC6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MgEXG7</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_21087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856545.1">
        <property type="nucleotide sequence ID" value="XM_003856497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYC6"/>
    <dbReference type="STRING" id="336722.F9WYC6"/>
    <dbReference type="GeneID" id="13395254"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21087"/>
    <dbReference type="eggNOG" id="ENOG502SH8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_2_1"/>
    <dbReference type="InParanoid" id="F9WYC6"/>
    <dbReference type="OMA" id="GDCQANA"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="359"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="725" mass="77303" checksum="2ECF24E58D99DC7C" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYH6</accession>
    <name>F9WYH6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_98802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856650.1">
        <property type="nucleotide sequence ID" value="XM_003856602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYH6"/>
    <dbReference type="FunCoup" id="F9WYH6">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYH6"/>
    <dbReference type="GeneID" id="13398817"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98802"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="F9WYH6"/>
    <dbReference type="OMA" id="TNCCLKA"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="38746" checksum="764DF6C5932375AF" modified="2011-10-19" version="1">MKAVRFHGKEDLRYEDIPEPKCGPGQVKVKPAWCGICGSDLHEYMGGPSLCPEKTPHPITGETVPLTFGHEFAGVIEEVGEGVSDRFKVGSRVVVAPIIYDGDCGACEDGLVNCCWKNGFVGLSGWGGGLSEHLVVPEYTLYNCPDNVPLDVAALVEPLAVGWHAVASSPFQEGDSALILGGGPIGLSVIQALRARGCEKIIVSEISGMRKQFAKDFGAHYVLDPTKDDIVKRCLELTNNKGVDVTFDAAGVQAGLDQAVNSLKARGTHVNIAIWEKRATFWPNDLVFKERKYLGVATYVKADFQAVIDALSDGRLDMAQKMITKRIEMGEVLEEGFLTLINDKDNQVKILVKGSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYZ9</accession>
    <name>F9WYZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_65626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        </source>
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    <sequence length="554" mass="63956" checksum="1C41857607A3C614" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13982" checksum="FC6FD834E69A84DA" modified="2011-10-19" version="1">MRAGTWITALKKAHFLRCSLHALSHIKPTLKIFYHPRRLPEPASPTITRPSPSPLPSPSIPQPRTSNRSTTTRTLRRSWMTTRVCTRRTCIVVFDHHPAHDNSRFSDLRERELLGYVPLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZU1</accession>
    <name>F9WZU1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_106959</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857592.1">
        <property type="nucleotide sequence ID" value="XM_003857544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZU1"/>
    <dbReference type="STRING" id="336722.F9WZU1"/>
    <dbReference type="GeneID" id="13394310"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106959"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.487"/>
    <dbReference type="eggNOG" id="ENOG502T9IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874949_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZU1"/>
    <dbReference type="OMA" id="SMNHIPE"/>
    <dbReference type="OrthoDB" id="10478173at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="318" mass="33120" checksum="0C5FE7A2B2E4610C" modified="2011-10-19" version="1">MATGNNDIAVDNLISALGAAASAANVPTPAMAQLPSAEAVSVLISALPSDVVASIQSEFGALRTPAPTPAPTSVAQSTPSSPSSTIPTSSQSTPTSSDFSSSSTTASSFTFSSSTISSTSSATPTSSAGASTHNGQKSHNKAAVAGIASGIIAGAVLLILLAAFLFKCRKEGYQWFCCCCGKKKQHPRPSRPYPQSAWLYDARPSPPDSLRRGAAESSDDALLPTRRHDEMRERDRVPDRFASPTRPARPSSPLLSPPKNPGRTASPILSSHSRIRMVPSSPRSSEVDARRAVKTTVAPAWGQGAKPMQATVEEYHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZZ7</accession>
    <name>F9WZZ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_102276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857485.1">
        <property type="nucleotide sequence ID" value="XM_003857437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZZ7"/>
    <dbReference type="FunCoup" id="F9WZZ7">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZZ7"/>
    <dbReference type="GeneID" id="13403056"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102276"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.723"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="F9WZZ7"/>
    <dbReference type="OMA" id="DEKWARN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP92461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="362" mass="39064" checksum="6F92448650721AAD" modified="2011-10-19" version="1">MSSYKFEGWLGEDKDSVKGNMRWGEFEPKKWTEDDVDIEISHCGVCGSDLHQLSSGWGETPYPCVVGHEIVGKAVKVGSNVKHIKQGDRVGVGAQARSCLQKDCPDCTNNLENHCAIGTVNTYGSVYPGDEGKSYGGYADYNRTHNRFVFNIPEGLSSAAAAPMLCGGITIFSPLKNYGCGPGKTVGIVGVGGIGHFGVLFAKALGADRVIGISRKSDKRDDALKLGADEYIATDEDKDWQTKHRRSIDLIVGTVSSAKMPLEGYLGLLKTKGTYIQIGAPDAGELPAINAFTLLTNGIKVGGSAIGSPKEIEEMLQFAADKKIEPWLNERPMKEANDVVQDMTAGKARYRYVLVNEKHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X017</accession>
    <name>F9X017_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_98392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X017"/>
    <dbReference type="STRING" id="336722.F9X017"/>
    <dbReference type="GeneID" id="13394508"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98392"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.745"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="F9X017"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000048">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="181" mass="20454" checksum="9EA5D9346B0BFA2A" modified="2011-10-19" version="1">MASPSTRNLNSPQSSAAIILGRQFKQMQTDKDIPGISCGLVGESVFEWEVMLMLSDEQDSLYGGGIFRAKMKFPNDYPHGPPTLKFETPIFHPNVYENGNVCISILHPPEEDQYGYESASERWSPVQTPETILLSVISMLSSPNDESPANIEAGKLWREDKKEFKKRVRKCVRDSQENAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X028</accession>
    <name>F9X028_ZYMTI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857368.1">
        <property type="nucleotide sequence ID" value="XM_003857320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X028"/>
    <dbReference type="STRING" id="336722.F9X028"/>
    <dbReference type="GeneID" id="13394779"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66126"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.978"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="F9X028"/>
    <dbReference type="OMA" id="DFWIDLY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="676" mass="75261" checksum="AE36562D5E16D772" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0J1</accession>
    <name>F9X0J1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_107627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856655.1">
        <property type="nucleotide sequence ID" value="XM_003856607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0J1"/>
    <dbReference type="FunCoup" id="F9X0J1">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0J1"/>
    <dbReference type="GeneID" id="13398809"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107627"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1725"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="InParanoid" id="F9X0J1"/>
    <dbReference type="OMA" id="RMDLGMT"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="200" mass="20568" checksum="1D8F494F787FD78D" modified="2011-10-19" version="1">MANVQDRGPPSAAAIAIGTGIIAGLTGYFLGQARSIGVFGRSHSASATSGAADDDSDLSDADEDETSPDDLGELKSFAGTNEECKLVLAVRGDLGMTKGKACAQCGHATLACYKALLRADPQNPVLRQWERLGQAKVALRVNSEDELLMLQAQAVSLGVCAQVVHDAGRTQIASGSATVVGIGPAPKSVVDQITGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1L2</accession>
    <name>F9X1L2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_90228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856891.1">
        <property type="nucleotide sequence ID" value="XM_003856843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1L2"/>
    <dbReference type="STRING" id="336722.F9X1L2"/>
    <dbReference type="GeneID" id="13398526"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90228"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1L2"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="166" mass="17657" checksum="5E130B8D975E3AB7" modified="2011-10-19" version="1">MSRPTATSRRSVKTEYIETDTGNKISRRAHIEGKQNIMLGASIISTGTTLHPPSRLHHGKLTYYPMRIADNVFIGANSQISSASISSHVHIGENCVLGPFSMIKEGCKVLPNTVVPANMMIPPGSVVAGRPARIVGEVGDGWGQVGSGEVEIVEGGDLKGLVRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Y6</accession>
    <name>F9X1Y6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_90338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854702.1">
        <property type="nucleotide sequence ID" value="XM_003854654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Y6"/>
    <dbReference type="STRING" id="336722.F9X1Y6"/>
    <dbReference type="GeneID" id="13395871"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90338"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="InParanoid" id="F9X1Y6"/>
    <dbReference type="OMA" id="CRNDELG"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="377" mass="41744" checksum="8AE1DD02AD9E07E7" modified="2011-10-19" version="1">MTAVEGYQDFDVPLDYFNPQPDHCQLDVGIVGAGIGGLAAAIALAKSSHNITIYERSKFSNEVGAAIVVAPNCSRILDYYGFDFEKAGATVFTEMEFIDGSTLAVNHNIPCDRTAEKYHGKWYALHRSDFHAQLRDHALSYPNVQLCLDAKVEGVDTRGVLTMKNGEVAHKDLIIIADGVKQASSGTLQNFGFFHADDLPFDDEVWDIEATTDDIRKDSQRLNPALQALCEHATQPRQWRLIERNKLIENLTKDNAVLIGDAAHPLLPFQGQGAAMAIEDAAVLGVLISQMSSRAEIPSRLALFQELRKDRVCAMQIFSRQQQDHASMDEAEKYVKGKLPTCPAEYHEFGLQPDVIADAKMLLQEHFVTDVISPCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X251</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_36134</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855704.1">
        <property type="nucleotide sequence ID" value="XM_003855656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X251"/>
    <dbReference type="GeneID" id="13403644"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36134"/>
    <dbReference type="eggNOG" id="ENOG502S92C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053549_0_0_1"/>
    <dbReference type="InParanoid" id="F9X251"/>
    <dbReference type="OMA" id="MNSQHND"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="221" mass="23981" checksum="B0ADEBFA807D9A75" modified="2011-10-19" version="1">MLNSIALNDPTIPAPGEMQPTNGSSHSGSPRVHRGSFNLHTADPNHHRHPSLGSLHQELENEQEAQVNRLLHMIRMQQDQIAAIQHQRGEPSPVPVDGNRYRTISSASNTPASAAVMEQSPPLAAATSAHVPRGHINRPHSLSRESSAWANSGGTSPALTAQSGTLAPLTEDFLLGGTRDDCAFYQAETSSLTRENQMLKKRVAELGELPCELRCYCLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2H5</accession>
    <name>F9X2H5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855465.1">
        <property type="nucleotide sequence ID" value="XM_003855417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2H5"/>
    <dbReference type="GeneID" id="13403405"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108147"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.758"/>
    <dbReference type="eggNOG" id="ENOG502S6ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588089_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2H5"/>
    <dbReference type="OMA" id="RALKPMT"/>
    <dbReference type="OrthoDB" id="5431149at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="464" mass="50063" checksum="7E6E5ADD5A030840" modified="2011-10-19" version="1">MAPITRSFDRSTLVFFTTAALACVTKIATTAVVVHLATWTLREGPNLPLAATASAFELFALVTFVACLWLFLRRVSRRLILIALVPAAVLGFVGTILSLITLALTFSITKTKAAERNPSGYRIEQQLTALGLAIGAIGVIPQTAFYILVLPRTSNNTSVSSPEDAVRTSSPGSRSDKRRSSSFTLTSLSARTSHYRSASAPDSPPHCKSPSSPGSSIKRSMSNSLRPMTSRTRLLFGTSFASRDSRSLYSRADSCTDHTRNNSDFENWDTSAVESQLDDPGLNRRPLETIPGSRPVSPADALDGPFSDDRSPEECPLHESSPTPRYSPTSDNGSPRLAPRAIVRKTSVPDQLHIHPLFRSESPVPPPLKSPNTVITASPYAGQIVSSELVGPRILHSAQSSRPGSPSRMTAGSRAGSVRSLRTMPTSPLPMEPDSRGRSHLAEASFPLRSERRDEVSDDETASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X300</accession>
    <name>F9X300_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_99195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855409.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X300"/>
    <dbReference type="GeneID" id="13399823"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99195"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
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    <dbReference type="OMA" id="ICAHAAP"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
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        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29758" checksum="FAECF943401BA988" modified="2011-10-19" version="1">MVLEVVYVVRHGYRSNWSVDPSTGHYDSNIPSPTGIVADPALASYGVAQAKQLGKHLISLSPPVDKIYSSPFYRCIQTLQPFTTELSKIDPKKATINLERGVGEFYGQARFDHPSPATIEVLNEHFPNLQQDREAIIVPSTKGESIPQLHDRVAYCLSHLIAAADADPNGPKAILICSHAAAMIAIGRVLTGNMPEDDTAEDFNCFTASFSKFVRRGKAQENPDFSAVKGSWDPAVAEKVPDVKWRGGAGVGGGWECEVNGDCSFLDGGEERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X325</accession>
    <name>F9X325_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855442.1">
        <property type="nucleotide sequence ID" value="XM_003855394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X325"/>
    <dbReference type="STRING" id="336722.F9X325"/>
    <dbReference type="GeneID" id="13399833"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68667"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.800"/>
    <dbReference type="eggNOG" id="ENOG502S6U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="InParanoid" id="F9X325"/>
    <dbReference type="OMA" id="RGARICH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="314" mass="34911" checksum="EBA34F9BAFF858D7" modified="2011-10-19" version="1">MADQNLKSLHSFFKENDTKISSGGNVKSFSHDTGSGPILCMVHGWPESSYMWRHMVADLKDEISLFVPELPGYGFSSLPPKNDKRTVGKLLIEALHSVFDSSRPIIWCGHDRGGRIGHRLLVDNDPSHNIISAILMDIVPTTEQWRSFSSPTASVAYAHWPFLAIPTAPYLIETLGGGIYCKDMIARAKGSNPTFAAKFKENDAIAHYCHQFSAPDCIAGSCGDYAAGATVDVEEQEKDQREGRKVGTEMMVLYSRGNLGRMHDVEKVWKDWIAEGTEVRFEGFGDGCGHYLPEEDPEKTTKLVKEWIARSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X359</accession>
    <name>F9X359_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855341.1">
        <property type="nucleotide sequence ID" value="XM_003855293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X359"/>
    <dbReference type="GeneID" id="13400737"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103423"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1008"/>
    <dbReference type="eggNOG" id="ENOG502S685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110797_0_0_1"/>
    <dbReference type="InParanoid" id="F9X359"/>
    <dbReference type="OMA" id="NPSDPIH"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="177" mass="18000" checksum="2B3E0A56D77A00F7" modified="2011-10-19" version="1">MSANRNPDGPGVGQEFSSRRDRDEPMMTSGHQPGKLVGNDAAPEFQAEILPAGSAPSAHTFKPNPIDDVPAGSGGVTASSTIGGASSADVHTGLGHPGSGQSSSELRHDGQSGRKNPGQSLEGVGATVSQSGINAHDPVHADQRALDKDEAVVGRSDVRGAHEKEPQGAQSVASERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4A3</accession>
    <name>F9X4A3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_68159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854885.1">
        <property type="nucleotide sequence ID" value="XM_003854837.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X4A3">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4A3"/>
    <dbReference type="GeneID" id="13399374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68159"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4A3"/>
    <dbReference type="OMA" id="IQLKWNN"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
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        <property type="entry name" value="FMP27_SW_RBG"/>
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        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2003"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2511"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2762"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1070"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1071"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        <location>
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            <end position="2774"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2784"/>
            <end position="2793"/>
        </location>
    </feature>
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        <location>
            <begin position="2794"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2846"/>
            <end position="2860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2877" mass="324789" checksum="793222ED89475152" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4C1</accession>
    <name>F9X4C1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_68201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
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        <property type="nucleotide sequence ID" value="XM_003855569.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.449"/>
    <dbReference type="eggNOG" id="KOG2280">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="InParanoid" id="F9X4C1"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VPS16"/>
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        <property type="entry name" value="Vps16_C"/>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
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    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="502"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="824" mass="92838" checksum="C87507296ABF61E7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4H4</accession>
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        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_36084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855498.1">
        <property type="nucleotide sequence ID" value="XM_003855450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4H4"/>
    <dbReference type="FunCoup" id="F9X4H4">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="GeneID" id="13403438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36084"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_0_1_1"/>
    <dbReference type="InParanoid" id="F9X4H4"/>
    <dbReference type="OMA" id="TNVMHFC"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
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    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="35221" checksum="CA669D3E61CA62F4" modified="2011-10-19" version="1">MADSDPSLSGFRYESMDWKKYMRFRPAYPQKLYDTVYAHHQANGGAYDSALDIGAGPGIISAEIGKKFKHVTLTDPSAEYVNAAKSYLASAVPDGNFDFVQTKAEDLAPSKLPKDEKVDLVVAGCCMHWTDANIAIPAIASILKPGGTFAAWTYGIRILFDRGENLDEVRDIYYSIWDKMMAHSIARSDKPIIAALAATDHRYDHIPFPTSTWSSVRRIHTNAGAPFCYSSNRPDHFPTLPSQALPSDSVEDFHDDGMLRKDEVDYEYLEGLLWSLMPDLDMKEFAGEELGTLKKALGGKRVGVRWPFVLVLATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4R5</accession>
    <name>F9X4R5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_69093</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855280.1">
        <property type="nucleotide sequence ID" value="XM_003855232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4R5"/>
    <dbReference type="FunCoup" id="F9X4R5">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4R5"/>
    <dbReference type="GeneID" id="13400525"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69093"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="F9X4R5"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="396" mass="45004" checksum="05ED9E0F041FAB2F" modified="2011-10-19" version="1">MPGRTLPTLPSAEVASHNTADSCYVTVGTKVYDITPFLEDHPGGGDLILDFAGRDVKEAMEDEASHAHSESAWEILDDYLVGFVATQKVLDAVQESSDPFSVLPMEPSKKGMEELSKAENGSVQEGKAVYESTGMSSEADLNKETDPNQDFVKHKFLDLNKPLLMQVWFGGFSKKFYLEQVHRPRHYKGGESAPLFGNFLEPLSKTPWWVVPTVWLPPVAFGTVLSGMQLGMPSLVGYWIVGLCIWTIVEYGLHRCLFHLDDHLPDNRVAITLHFLLHGIHHYLPMDRLRLVMPPTLFLVLATPFWKLAHTVFFYNWYAATAVYCGGIFGYICYDLTHYFLHHKNLPSYYRDLKKYHLQHHFMDYENGFGVTSRFWDRIFGTELAPPPTPKVLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    <dbReference type="Proteomes" id="UP000008062">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
    <sequence length="657" mass="71172" checksum="10FA4302FE6A878A" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="F9X563"/>
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        <location>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="247" mass="27485" checksum="5AE972522BAA4864" modified="2011-10-19" version="1">MNFVKQFVDKRSRLCPGTASSLPIVRLSWRTTYDETTNAETTADLRSTSESVPSGESEPDIWRQFRSSFDIPSQQARPAHQRLQEPLGRDALESVDFIETLAACPSWLVCTYRTQLGGCPPARGQELDPQPLRDVNQTMTLFKTAMLRSRTRAGRVVGTKSNYDVPEENMTKMQHLRTKISDAEKRLELVNTIFDILQKGSDEAAAEALARLRIGQSVDEVVNYMVAARANDQTGSSLESPETTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="25"/>
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        <ligand>
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            <position position="258"/>
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        <ligand>
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            <position position="321"/>
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        <ligand>
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        <location>
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        <ligand>
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        <location>
            <position position="321"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="De Wit P."/>
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                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854384.1">
        <property type="nucleotide sequence ID" value="XM_003854336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X693"/>
    <dbReference type="SMR" id="F9X693"/>
    <dbReference type="GeneID" id="13395570"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38105"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.610"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_1_0_1"/>
    <dbReference type="InParanoid" id="F9X693"/>
    <dbReference type="OMA" id="YEFPLRT"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390153" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="14520" checksum="2DB2AC0DE206FAEF" modified="2011-10-19" version="1">MRFSLLSSALLFATAAFSAPVAEPAELEIRQQATYCGNQYYSASQVSAAVNKGYNYYANGQQVGSGNYPHQYNNREGFSFAVSGPYQEFPILASGSTYSGGSPGPDRVVFNTRGQWGGTITHTGASNNNFVGCSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6M4</accession>
    <name>F9X6M4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_103568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854606.1">
        <property type="nucleotide sequence ID" value="XM_003854558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6M4"/>
    <dbReference type="STRING" id="336722.F9X6M4"/>
    <dbReference type="GeneID" id="13395792"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103568"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.148"/>
    <dbReference type="eggNOG" id="ENOG502S526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685160_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6M4"/>
    <dbReference type="OMA" id="ISTTARW"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="44748" checksum="C00940C7D4FFFB05" modified="2011-10-19" version="1">MDVLSASSLSLHNDLSLNNIMSSPDSSSTYLKMEDLHTTHSTSPAPSAFDDSLSTSQSSPAPVVVHSRQAKKRKSWGQELPEPKTSLPPRKRAKTDDEKEQRRIERIKRNRAAAHNSRERKRQETETLAVALARANAELQAYKKLHGPLPSNIVLPEIQVRNESPEAQTPVPSLVDDNSYPSPASPDDSIFHPTTSIKQEPLDHPTFSLNSLPPAFDTLDAKPSSSSLLLPLDPTQHSAAMLCDLQCRSSLKSSSTTTTTNSPPPSWWTQLFLHLLTGQILTCYRILMVALWTISPSRMARLMAASTLRSTSRSTISSTTPLLLRSTRRRLALCNTATGLRAPREGALTALQRRSLGRDRRVARCERSGRQVQVSRTTRAVFLGSSEDQGVGDDGNEQHGVGHGGDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X703</accession>
    <name>F9X703_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_39227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854341.1">
        <property type="nucleotide sequence ID" value="XM_003854293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X703"/>
    <dbReference type="STRING" id="336722.F9X703"/>
    <dbReference type="GeneID" id="13404273"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39227"/>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="InParanoid" id="F9X703"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29269" checksum="50A73E58FC1DBDC4" modified="2011-10-19" version="1">MAPAPEVDFAEYVSPAFHHFERRDLTVNRTQAITVGVIGVYVVVIALLWNIPYVKNVLWPFKMLTIAFHEFGHAMAAVLTGGKVESIELNPNEGGVTHMRGGKQFFTLPAGYLGSSLIGGLLVFCGFNIVASKVASIVLGVCFLLTLWWARKDWLTIVTIILATGLLVGMWFVNSGLGLRFVVLFIGVMSSLYSVWDIADDLIIHKINSSDASVFAKRYGGSSRCWGLIWSSVSVCFLAAGIVAGIAVFRQDFAQQKQDSDDFIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X780</accession>
    <name>F9X780_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853788.1">
        <property type="nucleotide sequence ID" value="XM_003853740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X780"/>
    <dbReference type="GeneID" id="13395653"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103686"/>
    <dbReference type="eggNOG" id="ENOG502RV5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909138_0_0_1"/>
    <dbReference type="InParanoid" id="F9X780"/>
    <dbReference type="OMA" id="NTKRDND"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="31175" checksum="225FB3749EA40A2C" modified="2011-10-19" version="1">MSSYDNDNDNSGSRSGGSYGDNDNSRSGGFGDDNNRGGNDDSYGSSGRTGGDDSYGSSGRTGGLSSSNDNDDSYGSSGRTGGDLSSSNDNNSYGSSGRTGGGLSSSNDNDSYGSSGRTGGGLSSSDDNDSYGSSGRTGNLSSSNDNDSYGSSGRTGGGLSSSNDNDSYGSSGRTGSGLSSSNDNDSYGSSGRTGGGLSSSNDNDSYGSSGRTGGGLSSSNDNDSYGSRGHTGAISSSNDDSYGSGNTGSSGFGGSSGRNDNDSYGSSNRDDNNSSGKDSTAGKLLEKAGSLLGNNKIEQSGREKREQAGQDDNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7A3</accession>
    <name>F9X7A3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_39665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853942.1">
        <property type="nucleotide sequence ID" value="XM_003853894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7A3"/>
    <dbReference type="GeneID" id="13395514"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39665"/>
    <dbReference type="HOGENOM" id="CLU_2291342_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7A3"/>
    <dbReference type="OMA" id="WYITEHA"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="11504" checksum="C074763B435C34CD" modified="2011-10-19" version="1" fragment="single">MQLVFTPTYEAPVKRSLSNLGIWLINGTLLDTFARLGTIVANHQLQFDAFSQSGAIYTAGFSACGPTNARVLALGGNTTFWGCTSGGFANIYDENVAPQCVAAEIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X812</accession>
    <name>F9X812_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_85479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
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    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
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            <begin position="56"/>
            <end position="157"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="161" mass="17571" checksum="DE9533894619BC90" modified="2011-10-19" version="1">MYRSESRFFRPDEAAVHAEVIDVDLGECESFVAIHPSSDRVFPVKDCVGESSNGCIFGACTTTEEDLILAALVLRVGLQQGLELSKEKRIVVAVSLPIARNLRDMGLLDIFTKCGFEQPAPGCSMCLGIAGNIAEPGFRWLSSQNQMFKDRMGKGTSARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10165"/>
    <dbReference type="eggNOG" id="KOG1192">
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    </dbReference>
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    <dbReference type="OMA" id="SFAHIHV"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
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    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
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            <end position="518"/>
        </location>
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        <location>
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        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EGP88481.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
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    <sequence length="1063" mass="114800" checksum="46DB938E70590101" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Bristow J."/>
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        </source>
    </evidence>
    <sequence length="213" mass="22007" checksum="AAFC539BD3491C0C" modified="2011-10-19" version="1">MPCCRQLLVSDRRAEHDGTRPASACPGPWNADLLHLTFHSLALDFRFLSFEEQIAIYLPAFVGELAGAVDDVVEAVVVDGVVDDGVDDAVVDDGVMDDGVVDDAVVDGVVDDGVVDDAVDDAVDDAVVDAVVDAVVVNAVVDAVVDGVVVDDVADSMVDAVVDGVVDSVDGVVDGVVDRDEDELVPGTVEAVLTCEVEAVILVVVLVAVLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA67</accession>
    <name>F9XA67_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_71117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853422.1">
        <property type="nucleotide sequence ID" value="XM_003853374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA67"/>
    <dbReference type="GeneID" id="13397309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71117"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.418"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="F9XA67"/>
    <dbReference type="OMA" id="VAQFLCM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="501" mass="55297" checksum="0CE6234E95A28355" modified="2011-10-19" version="1">MALPPKWYQFLVSVFASLGSLLYGYDLGVIAGAVDSENFKSTFQPTKAEVGAVVSVFTGGAFFGAMFAGPCGDFLGRKKTILLGAVIFLLGGALQTGAQALSYLYAGRAIAGIGVGFLVMIVPLYQAELAHPDIRGRVTALQQFMLGVGALVASWVSYATYTYIPASSSNQWRVSLGIQIIPAGFLALLIMFFPESPRWLIDHGKADEGLRTLAKLHAHGDENDTWVRSQFNQIQDMITFEHEHEAKSYTELFTNKSSFRRLFLACSIQASVQMTGVSAIQYYSPEIFRQIGIPGSKTLQYQGISSIIALIAQFCCILFIDWTGRRWAMIGGNLGNCLTFIIATILLAQFPPGASNNQAASWGFIVVTWAYNFSFSATNGPLSWIVPAEIFDTRTRSKGVSIATMTSFAFNTMIGQVTPIALESIGYKFYIVFVVCNFTNALFFWAIQPETAKRPLEEMNYLFTNAPIFIPTMDTREFNRLDLENRVMEAEYKQHAAGHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA99</accession>
    <name>F9XA99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_40222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853003.1">
        <property type="nucleotide sequence ID" value="XM_003852955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA99"/>
    <dbReference type="STRING" id="336722.F9XA99"/>
    <dbReference type="GeneID" id="13400224"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40222"/>
    <dbReference type="eggNOG" id="ENOG502RXN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035149_0_1_1"/>
    <dbReference type="InParanoid" id="F9XA99"/>
    <dbReference type="OMA" id="PRPAYLM"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36284" checksum="2E66965B08547F0C" modified="2011-10-19" version="1">MEPAYTFTLPSIHDDIALSVRLYHPKNLSHVIMDIKEPRLALKGAVIAHPYAPFGGCQDDHVVLAVTHCLLKQGYIVVTFDFRQVLRAGDSAGKTSWTGSPEVGDYTSAIGLLVYYLHTDAQELDKPSSKLQVILAGYSYGSLILARLPHMSHIIETFESAEKGTSASEIYLRARTLARRTRQSLLEPSPPSTPRGRRLNSESSPRSRPQTSQVNVSYLMISPVLFPMTTTLLSPGLAFPTAKAGNTGSGFLSMEYSSMVLFGSLDHFTSAKKLKQWVERLSTTSSGRLQWECFQGVDHFWRGDGVLDEVQARIKTWTSSSTEQSLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB43</accession>
    <name>F9XB43_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852379.1">
        <property type="nucleotide sequence ID" value="XM_003852331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13394156"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93550"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.795"/>
    <dbReference type="eggNOG" id="ENOG502S6HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261237_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB43"/>
    <dbReference type="OMA" id="KAFWHEV"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1304" mass="146177" checksum="0AC38C12FB9801E0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC13</accession>
    <name>F9XC13_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_80798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852179.1">
        <property type="nucleotide sequence ID" value="XM_003852131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC13"/>
    <dbReference type="FunCoup" id="F9XC13">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC13"/>
    <dbReference type="GeneID" id="13393955"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80798"/>
    <dbReference type="eggNOG" id="KOG4267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096652_3_0_1"/>
    <dbReference type="InParanoid" id="F9XC13"/>
    <dbReference type="OMA" id="YGLFTFG"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="10964" checksum="539DDAE06457C216" modified="2011-10-19" version="1">MVSTLSTIAFVLGALTAGGGITGYVRTGSIPSVTAGCTVGAFYLLGGYRISNRQSYGVELALLASVILAGSSFPRAMKSGFKPLPTGLSVLAAVGLVQFGMAFVNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC35</accession>
    <name>F9XC35_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="13">dUTPase</shortName>
            <ecNumber evidence="5 13">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_59391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5 13"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852489.1">
        <property type="nucleotide sequence ID" value="XM_003852441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC35"/>
    <dbReference type="FunCoup" id="F9XC35">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC35"/>
    <dbReference type="GeneID" id="13394104"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_59391"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_2_0_1"/>
    <dbReference type="InParanoid" id="F9XC35"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000007">
        <property type="entry name" value="dUTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="15">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP87465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="218" mass="22938" checksum="741305F0FF602A85" modified="2011-10-19" version="1" fragment="single">MAQTPQPEHEAPSLPSSPFPKRTKYTEPAPNLTVASILNDDAPTPTPSSAFASEPLPTMSTIPPPQTTTLPSMSFEPPPPALQVKLLAPTAKAPTRGSQHAAGYDLYASRPATIPARGKALVELDISIAVPAGTYGRVAPRSGLASKHGIDTGAGVIDADYRGPVKVLLFNFGEKEFEINEGDRVAQLIVERIYTPEVVVVEELEETVRGAGGFGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCR4</accession>
    <name>F9XCR4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Linoleate diol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_100421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851942.1">
        <property type="nucleotide sequence ID" value="XM_003851894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCR4"/>
    <dbReference type="GeneID" id="13393719"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100421"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002329_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCR4"/>
    <dbReference type="OMA" id="EEPAHAF"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="102840" checksum="C9B5C310EA70536C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV1</accession>
    <name>F9XCV1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851398.1">
        <property type="nucleotide sequence ID" value="XM_003851350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCV1"/>
    <dbReference type="STRING" id="336722.F9XCV1"/>
    <dbReference type="GeneID" id="13393704"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109766"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.169"/>
    <dbReference type="eggNOG" id="ENOG502RYPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349896_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCV1"/>
    <dbReference type="OMA" id="CNHHACY"/>
    <dbReference type="OrthoDB" id="5427134at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="435"/>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Hane J.K."/>
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                <person name="Bristow J."/>
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                <person name="Dehal P."/>
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            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851355.1">
        <property type="nucleotide sequence ID" value="XM_003851307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEE8"/>
    <dbReference type="STRING" id="336722.F9XEE8"/>
    <dbReference type="GeneID" id="13393746"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43805"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="InParanoid" id="F9XEE8"/>
    <dbReference type="OMA" id="VRTDYMF"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37077" checksum="B2D47C1E0D761F14" modified="2011-10-19" version="1" fragment="single">VNGHVQSIWTSETSCWSVPTFVQDPLLCIHGLSSGLNYGQQVFEGLKAFRHSNDDVHVFRPQAHAARFAQSASLAAIPPVPHELFMRAISMAIELNSEYVPPSSMRQAALYIRPLALASSPALNLRRATQFHFAVYVIPVAAAQKARLEGARALVVEDFDRAAPQGTGRAKIGGNYAPMTVVMERAREQQYDLTLHLDSATHTMIEEFSVSGFVGVRRDGPVTTLLVADGPTVLKSITADSLCQLASSFGWEVDRRQIQFDEVRGFHEAFAVGTAFVLTPIQSITRRSTSETIRFPGRYQDAESSYHRLCEAFKGIQTGERPDTWTWMEKVPIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEG2</accession>
    <name>F9XEG2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_93679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851961.1">
        <property type="nucleotide sequence ID" value="XM_003851913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEG2"/>
    <dbReference type="GeneID" id="13401268"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93679"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.97"/>
    <dbReference type="eggNOG" id="ENOG502S3ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079949_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEG2"/>
    <dbReference type="OMA" id="HAMDHAC"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="158" mass="17135" checksum="66D88F079F3C3C62" modified="2011-10-19" version="1">MNSSNWLYAGPSSSIPDLSTSNTPTSDTKFTSADSSSPPPCLILSLAASPPAALTPSAASLTIAPEPQLLIFRYRSKIHAIDHSCPHQSYPLSDGSIYDIEDFGIVLSAGIACPKHGWTFDLFTGESDRGGYKLGVWDVEVRGEEVWVRRRPKKKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEH1</accession>
    <name>F9XEH1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_28226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851646.1">
        <property type="nucleotide sequence ID" value="XM_003851598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEH1"/>
    <dbReference type="FunCoup" id="F9XEH1">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEH1"/>
    <dbReference type="GeneID" id="13401986"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28226"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="InParanoid" id="F9XEH1"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="172" mass="20075" checksum="6C5679F06FCF70E8" modified="2011-10-19" version="1" fragment="single">NLRYISYGYERESPFLPAIKQLISKDLSEPYSIYVYRYFLYQWGDLCFMALDEQDELIGVIVCKLEPHRGGPMRGYIAMLATRSEYRGQGIAGKLVRMAVDKMIEKDADEIALETEVDNIPSLRIYENLGFIRTKRLHRYYLNGNTAYRLLLYLKPGIPFMKTLPPDYLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEJ0</accession>
    <name>F9XEJ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_94167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851690.1">
        <property type="nucleotide sequence ID" value="XM_003851642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEJ0"/>
    <dbReference type="GeneID" id="13401902"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94167"/>
    <dbReference type="eggNOG" id="ENOG502STQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477526_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEJ0"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="571" mass="63562" checksum="57A02C75D040BAEE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEJ6</accession>
    <name>F9XEJ6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_94173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851660.1">
        <property type="nucleotide sequence ID" value="XM_003851612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEJ6"/>
    <dbReference type="STRING" id="336722.F9XEJ6"/>
    <dbReference type="GeneID" id="13401871"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94173"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.689"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057081_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEJ6"/>
    <dbReference type="OMA" id="CENNIPI"/>
    <dbReference type="OrthoDB" id="10254982at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
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        <property type="entry name" value="Deoxyhypusine_synthase"/>
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        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    <keyword evidence="6" id="KW-0520">NAD</keyword>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="324" mass="36456" checksum="3D60DE2D7444A347" modified="2011-10-19" version="1">MSSMKTFLRHNFRHFNAATVVDAADGWQAVLDQSGKMLLTMGGAMSTAEMGLSVGQLIRQDKVHALCVTGANLEEDIFNLVAHTHYRRIPNYRSLTAKEEMDLHDQGLNRVTDTCIPEDTAFEKIRHQVLDVWQEAEKNNERLFPYEMFYRILRSNRLESKYQIDPADSWLVAAAEKDLPIWTPGWEDSTLGNFFAACTLQGKVSSPLLMKNGIEQMHSLIAWYRKTSTTSPIGFFQIGGGISGDFPICVVPLIHKDLELPCPLWACFAQISDSTTSYGSYSGAVPNEKITWGKLNENTPKFVIESDATIVFPLIAHYLLEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEM2</accession>
    <name>F9XEM2_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_94196</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851674.1">
        <property type="nucleotide sequence ID" value="XM_003851626.1"/>
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        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEM2"/>
    <dbReference type="GeneID" id="13401887"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94196"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.718"/>
    <dbReference type="eggNOG" id="KOG0262">
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    <dbReference type="HOGENOM" id="CLU_000487_2_2_1"/>
    <dbReference type="InParanoid" id="F9XEM2"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
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    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
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        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
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        <property type="entry name" value="RNA_pol_asu"/>
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        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04997">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="366"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1350"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1350"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1392"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1436"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP86650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1722" mass="188906" checksum="91DBAE2A77A14A4D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF20</accession>
    <name>F9XF20_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_81456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81456"/>
    <dbReference type="HOGENOM" id="CLU_2962664_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF20"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="59" mass="6636" checksum="5A08A1E7DC1445B4" modified="2011-10-19" version="1">MTTLYPMRNLPFNLQNLARNSNPPSPLMCPNCGPMMPLQHPPSQTSLQMPQALSQTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFJ4</accession>
    <name>F9XFJ4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_94399</name>
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    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="InParanoid" id="F9XFJ4"/>
    <dbReference type="OMA" id="KTDERYW"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="162"/>
        </location>
    </feature>
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        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="545"/>
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    </feature>
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    </feature>
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            <end position="329"/>
        </location>
    </feature>
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            <end position="291"/>
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    </feature>
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        <location>
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            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65957" checksum="A7941565E84A696C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG95</accession>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
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        <location>
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            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="220" mass="25190" checksum="2C7A24F843CBF1BF" modified="2011-10-19" version="1">MAPKTNCNSVKLNSCLSYLQRTRVAHTIKDLEKQLPSVASINGMQVKDYLQTLQDENKICVEKIGSGNWYWSFPSQDQIVKQKILGEVQSGHDKAFTIVQDLKQTFADKAAQREEEEEMVDTGGESREEVMKEKSELEAELKQLQKELAAYRDSDPTELERKQKETKELFANIEQYTDEIYSLEAWFRTMGGEDAVKGLQQAIYGDEYDEEEGGLREMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGJ5</accession>
    <name>F9XGJ5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGJ5"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100832"/>
    <dbReference type="HOGENOM" id="CLU_112614_2_1_1"/>
    <dbReference type="InParanoid" id="F9XGJ5"/>
    <dbReference type="OMA" id="CCEAMIG"/>
    <dbReference type="OrthoDB" id="3703354at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12151" checksum="DB815BB7348CF51E" modified="2011-10-19" version="1">MNAWLPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFCPFALLEISVLHESPLGHLRYGLTDVPPQPNSPPDNVINPDRPAKDLNARKWSVKTSSASLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">RING-type domain-containing protein</fullName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850829.1">
        <property type="nucleotide sequence ID" value="XM_003850781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGQ9"/>
    <dbReference type="GeneID" id="13397567"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94681"/>
    <dbReference type="HOGENOM" id="CLU_1344194_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGQ9"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="23414" checksum="A8E1C90C8166E020" modified="2011-10-19" version="1">MATPRREFRHPTAEDDFMAVATYDQEQRLREAETEPTHDWRAAQIRRLANRVEMFNSERGDMQQRTGKGPGSLTTLPSGVATLKLRHSVRCCVMSLGFSTPMHQTWDDFVESKTSAQHVHTYKLQEITRNLKTVVIDEPHVHQSSFRQKQMSEWCIICHDERIVVGGEAPCGHVCCALCMVTTVLELKKCPKCRHEVTFEELLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH11</accession>
    <name>F9XH11_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH11"/>
    <dbReference type="STRING" id="336722.F9XH11"/>
    <dbReference type="GeneID" id="13394600"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95395"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.655"/>
    <dbReference type="HOGENOM" id="CLU_1300567_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH11"/>
    <dbReference type="OrthoDB" id="10347684at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="212" mass="22856" checksum="9C5F63850CBADA92" modified="2011-10-19" version="1">MSAPSAFEKAQAAAAKIAAKVSKQQEQKFASHTKRKIENFASNFHATLEVNHLTTLARLAATSAGTIAQVSNTGGALTVRGKFYSGNSQPASARDEPKLNVFVEGMTEAIVRAAMALVGRYIQEGVIKDRTASAREKASRDEKLLASVKAKQRQKEDDRAREDPYGAMGNPGKDKEDRDLEAVEPALGGAQAVDQTPILLKWQTSWAGEIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHE7</accession>
    <name>F9XHE7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45976</name>
    </gene>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850195.1">
        <property type="nucleotide sequence ID" value="XM_003850147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHE7"/>
    <dbReference type="ESTHER" id="zymti-f9xhe7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13394556"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45976"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="InParanoid" id="F9XHE7"/>
    <dbReference type="OMA" id="WGQFTYG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="5"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="531" mass="57954" checksum="64DB5865ED273FAC" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIY9</accession>
    <name>F9XIY9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849282.1">
        <property type="nucleotide sequence ID" value="XM_003849234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIY9"/>
    <dbReference type="GeneID" id="13398889"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95521"/>
    <dbReference type="HOGENOM" id="CLU_558020_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIY9"/>
    <dbReference type="OrthoDB" id="10656006at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55291" checksum="68B608C9F9B9CD12" modified="2011-10-19" version="1">MSSPPLHTAEVAQVSNVGNTSIDEPPQKKGLPQAVENKNMVSSKKTSLQLPPLLRLPPELRNRIYSFIFPAPPPEISKTYPPNLDSGGYHKNSHKSTGYLSHALLQVNRQLRRETFKIFFSDSVFIFNNLKKLVKCLEALPRESVEAIRNIHLDIPRLDNKPPMSGPYNSRLIYQHVIAQLQTKQQRRLDVLLANSGVKDLSKDAVKIWFQTALGLVMLRFRADWRAEMLAQEESIHETKLDVNMPSHSFASQNKFFQLFSFLPFQLHLNNNIKISASSNSPNSSWRKMASSSPPTGTSKFEQVSTLPPLLRLPPELRNHIYAFIFPAPPADSFTESPPHPLHHPTGTAHLFPAILRVNRQIRREAFEMAFSTTIFEFTKSSAVISYLRTLPREFVEAIENIHLTYPGCVEIFDTQRNMHLVWIEVAMTQCFELHTLRVMLDTGGVEGLKDGVAKVWVQVGVEGGSWTAKPMGCFQKAQNRRLAGEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ03</accession>
    <name>F9XJ03_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849291.1">
        <property type="nucleotide sequence ID" value="XM_003849243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ03"/>
    <dbReference type="GeneID" id="13398912"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95534"/>
    <dbReference type="eggNOG" id="ENOG502STU2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622886_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ03"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="440" mass="50106" checksum="DE28B2F425A91562" modified="2011-10-19" version="1">MTNKLMVDGTEILAESDTVVLDSGTVNVIVPTAVARKLFTALNIQIVEQTLPGCTNSIFGYYPCDKPPTVGFQFGDKVFNIESSRFQLEDNGNNNCTAIITGIDVTEKHPNLWLIGQAWMQGKYVDFRKKDDGYEIGVADLKYLPMASTPYQYNDREFWGQNALQLACCAVRAGLAHFPFNFNPNIDILSANIVYCYLIMATTKLQALLPSSVSGPKQAQDSQLTSLAPELRNRIYALVFVGYINDALANEKDARSTTAATPGLILACKQFHQEALGIFYSHAGFQFCDLYRLSLWKERIGKARTKFIHHVRVLSSYLHTDWFDETDDESCTAGYCRDIGQASDLEIWYRTGWHHDKSINRKFYLWTRDPLEAAVDWKKYLAMRRVHIFALFDKEIERLLAQIARKDLHPSWILDVEHAHHGVGEDRWDKSEVKTFWSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJI7</accession>
    <name>F9XJI7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_62256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJI7"/>
    <dbReference type="FunCoup" id="F9XJI7">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="13399051"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62256"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.213"/>
    <dbReference type="eggNOG" id="ENOG502QRFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096561_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJI7"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395539" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="23390" checksum="DBAFCB30D3444102" modified="2011-10-19" version="1">MFPIILAVAASLCTTAQAHGSHAHEQAPIVAEDADWTTRHMAEEHHIANFDAGSFFTLHDFDSSNEWTHDDIYKFYGLDHESTSQISSADKEEAVNKVIKLYDRDASGTVSFAEYTVGTAQGITLPDFGWGPGHHGDDEYEYEIHHWEKYHDENTKEEDLIHPEDIEHFRHHEEMDEQEERQRVMDQQAIVEANIPEKFRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJR8</accession>
    <name>F9XJR8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_47419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849852.1">
        <property type="nucleotide sequence ID" value="XM_003849804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJR8"/>
    <dbReference type="GeneID" id="13402649"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47419"/>
    <dbReference type="HOGENOM" id="CLU_214130_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJR8"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="50" mass="5194" checksum="4C00D1DEC270FB34" modified="2011-10-19" version="1" fragment="single">ISPNGVCGGPNNYNCVGSEYGDCCSQYGFCGSGYEFCAAQNCLTDYGSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKB9</accession>
    <name>F9XKB9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_87626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849525.1">
        <property type="nucleotide sequence ID" value="XM_003849477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKB9"/>
    <dbReference type="STRING" id="336722.F9XKB9"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="13402389"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87626"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_5_2_1"/>
    <dbReference type="InParanoid" id="F9XKB9"/>
    <dbReference type="OMA" id="RLWCAFT"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="46906" checksum="8889698B8FE80C9F" modified="2011-10-19" version="1">MFSPKSKSRKVEKGGDLACMFVHAGAGYHSRDNEIHHLQACQDACKAGMAVMRGGGSAVDAVEIAIKVLEDREITNAGYGSNLGYNGVVECDAIIVNHNGSSGAAGAVAQIKNPISLARLVHDHSTQTLSLKRVPPNILVGQGATNFAYAHGMPIVSFDDLISPYAKARWQKWRADLIKSEQADSTLTQSEIGRTDTSSPIDCQTDGPSSTPSRSTADAAQQNTRFGSGDGESMNPKFTTSKTPQTEPGIPAAGEDHITDTVGAIAIDIYGNIACGASSGGIGMKHRGRLGPAALIGIGAAIIPTDEDDPDLTSVATVASGTGEHMTTTLAASVCSERIYHEQRRVKGGYKQCTEDEAITGFIKTDFMDHPSVRHSQSAGTIGVLSVKKTKDGVWLYFGHNTDSFALASMHSDEQKPICTMSRSNGNGTIAQGGRAVKFRRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKH4</accession>
    <name>F9XKH4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849560.1">
        <property type="nucleotide sequence ID" value="XM_003849512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKH4"/>
    <dbReference type="GeneID" id="13402343"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95983"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.615"/>
    <dbReference type="eggNOG" id="ENOG502RSI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597460_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKH4"/>
    <dbReference type="OMA" id="DYWNRND"/>
    <dbReference type="OrthoDB" id="3903104at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="298"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="458" mass="51642" checksum="AED7D07F8CCA2047" modified="2011-10-19" version="1">MVELGLCPLLPASSDEAESSDEEAFEEAFEGVFEDEFDEAGGGVEVEERPERVPLKEPEGGGNIVVDEKDHGLCEPVDTEPRSSRFEPLLGEAHERVVKPVAVVGGDDEDIPKAFFTIQMADKKDFWKFDTWWPEHAVVRESSMSSYRFQQIKAALHLEDPSSTPSVSLDEVLIRFTGRSFYVVNMRSKPTPIGYYILALCERGYLLEIAGVVRPREVTIAKAQKAAKKVVVKRKKKDNSTRNEVVAAPAAPAAATLLPPPPLLPNPDDSVNLTSELADRSKAVVCLILHTLRVALAQGKFFYIYIDNLFSNVPLYAVLRAYGIAATGTIRNNSKLWPWQGAEFKRTKKGVTKLVKLARKTTNFPFDLILYRPLYNVSAVLWQDRQLVQFLTTGYTIDERVNRLRRKPRPVNAFIREHVRPHWQEAREHKLVPLVAAYYNDYIGGVDIHDQLRSYCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX6</accession>
    <name>F9XKX6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_75993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849232.1">
        <property type="nucleotide sequence ID" value="XM_003849184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX6"/>
    <dbReference type="STRING" id="336722.F9XKX6"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="13396589"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75993"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.43"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKX6"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="328" mass="37456" checksum="6D3AC78BE75757A8" modified="2011-10-19" version="1">MSGGWNTIESDAGLFTSMMEELKVENVQFEELISLDEDSLQQLNPIGVIFLFKYQTDEKRSKDTPLDGEFDYAALEYKDDEEPVWFAAQTIQNACGTQALLSVLLNKDGTQEEGKVNIGPNLKEFKEFTSAFPSDLRGEALSNSDLIRSVHNSFARSSPFVSDETRMATSSDDVYHFIAYTSINSTLYELDGLQPAPIRHGDVGACPSEIFASSVIPVLQRRIERYPQTEIRFNLLAMCEDLRSRAREVGDEEWLMREEAKRREWRWENALRRHNFVGFIAEVMKGVTGQKLKEGKYDAWVEDAKKVTSKRMEERQKKGEAPDEMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL87</accession>
    <name>F9XL87_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_49256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848783.1">
        <property type="nucleotide sequence ID" value="XM_003848735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL87"/>
    <dbReference type="STRING" id="336722.F9XL87"/>
    <dbReference type="GeneID" id="13398750"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49256"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL87"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="166"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="292"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63204" checksum="576776CAA15F3FAD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLK0</accession>
    <name>F9XLK0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848814.1">
        <property type="nucleotide sequence ID" value="XM_003848766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLK0"/>
    <dbReference type="STRING" id="336722.F9XLK0"/>
    <dbReference type="GeneID" id="13398647"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28145"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="InParanoid" id="F9XLK0"/>
    <dbReference type="OMA" id="FGGQWVN"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18873" checksum="0E5304CFEC083A99" modified="2011-10-19" version="1" fragment="single">PTPSSSATSKTRDQQADADLEAFLKEIGASDQTATTTNTSQTAPQEPPKPHFPSRVRPDGTLDISPQAIYPRTMSCRAAFDQAFYCQSIGGKFNDIYRYGHLRQCSEQWGAFWFCMRTRTLPAHEKEKAISEHYAMRDVERKKVANSEDVWELRTTAVERAFARDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLL1</accession>
    <name>F9XLL1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_110986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848821.1">
        <property type="nucleotide sequence ID" value="XM_003848773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13397991"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110986"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.181"/>
    <dbReference type="eggNOG" id="ENOG502R9M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244612_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLL1"/>
    <dbReference type="OrthoDB" id="3946808at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1593" mass="176797" checksum="FDEC32D376F3F202" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLQ6</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_111102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849073.1">
        <property type="nucleotide sequence ID" value="XM_003849025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLQ6"/>
    <dbReference type="GeneID" id="13398175"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111102"/>
    <dbReference type="eggNOG" id="ENOG502SSYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313133_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="557"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="936" mass="105199" checksum="C68735BA1B1592B3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLR6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="13">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MgGpa3</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_76503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848934.1">
        <property type="nucleotide sequence ID" value="XM_003848886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLR6"/>
    <dbReference type="FunCoup" id="F9XLR6">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLR6"/>
    <dbReference type="GeneID" id="13398464"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76503"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.413"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_0_1_1"/>
    <dbReference type="InParanoid" id="F9XLR6"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </location>
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        <source>
            <dbReference type="EMBL" id="EGP83910.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="40780" checksum="AA7E1B444E08E16B" modified="2011-10-19" version="1">MGACMSSGNNEEGDQKKRSQMIDRSLEEDSKKLRRECKILLLGSGESGKSTIVKQMKIIHQNGYSHDELQLYRHTIYKNLIDCAKALVGAMRQFEIEIENEANRAHCDTIMEYTVDPDPQQSLDPKIGEAVAGVWKDPCISKVFDHQNEFYLMDSAPYFFDEALRITGPDFIPTEADVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRAKLAKSPLGNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLW1</accession>
    <name>F9XLW1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_96363</name>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84023.1"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="302" mass="34223" checksum="BE9C40629E31F6B0" modified="2011-10-19" version="1">MAPTTPKVRRSTRVQEAPALKKQKEEEEALKLASPPPSTIKSKSVKSKTTPKAKSTTTPKTKVLKSKPTPKPKTKFVGYPTINDVKFSDPPNGRTKPMPKFWTNADASAGIDAGYYWKNAIGEVYLAMDCLNGVCRKLEEVNDGHKGNQGLYQARDLLREWRDWTIKDDTFTHPLAPKSTLPTDNSVTHEPSQPATPKKMFPYLYPPLEPDYEPKWQPMWGTWPTAPKQGPKACTFDKYYYFSFLGDAPRAQRALESLCKTLEESGFGGDVEKANKPLFDARDVLREWTEWRDSIPPDEYSY</sequence>
</entry>
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    <accession>F9XMA9</accession>
    <name>F9XMA9_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96847</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848453.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96847"/>
    <dbReference type="HOGENOM" id="CLU_1490154_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMA9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="181" mass="19196" checksum="D5EC491BEBC412D2" modified="2011-10-19" version="1">MESHNSAAAKSNTPTAPDTDMWAHSLNQARKDSATDQVQSTQNSDEEELKIDDVEGITDTMPGVSDAEASSFQEDDSSTSLDVVDSVLVDVSITTEENGITRKQEVAATDPQDGYVHSEENGSQAAETPSGSPRGAMPTTIPPQLTTISSILSSETLKAPRGVCSEHGADIITVKYPQDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMJ1</accession>
    <name>F9XMJ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_49868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848279.1">
        <property type="nucleotide sequence ID" value="XM_003848231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMJ1"/>
    <dbReference type="STRING" id="336722.F9XMJ1"/>
    <dbReference type="GeneID" id="13396100"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49868"/>
    <dbReference type="eggNOG" id="ENOG502SICN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_9_0_1"/>
    <dbReference type="InParanoid" id="F9XMJ1"/>
    <dbReference type="OMA" id="NRMITSC"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="878" mass="99661" checksum="5583888023EDB730" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMV2</accession>
    <name>F9XMV2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848652.1">
        <property type="nucleotide sequence ID" value="XM_003848604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMV2"/>
    <dbReference type="STRING" id="336722.F9XMV2"/>
    <dbReference type="GeneID" id="13396302"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96582"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.171"/>
    <dbReference type="HOGENOM" id="CLU_1031363_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMV2"/>
    <dbReference type="OMA" id="SHIALYT"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="270" mass="29891" checksum="8AE355E6747311F4" modified="2011-10-19" version="1">MTDQSTYRTYETAPEQGSFSGHHASSSQTPTRETGTYARSDSTVVDSADEWCGKKIFDSVLAESIFRAIVGSDTTKDPKDVFSHVVGEFPYLACAREVRSIAHLEAARAQTGAQDHKAALMGSIGAAIRQGGDGIQTELKAIVQDYGLSKVPGIRLDRAAPSHRRDARPPRLPSPPLSDDDIDEIPRQFHDQTAVSRRVAPGISPGIYTAKLHLWMQSEGKNFHYDYRPLDTLETQAHLRLDGQDFTAIRRKKLDAKHEVSRQACVHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMX5</accession>
    <name>F9XMX5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_49350</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848637.1">
        <property type="nucleotide sequence ID" value="XM_003848589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMX5"/>
    <dbReference type="FunCoup" id="F9XMX5">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="GeneID" id="13396295"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49350"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="InParanoid" id="F9XMX5"/>
    <dbReference type="OMA" id="YMSEYWK"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="288"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="42405" checksum="73E1A4B4B69CED6E" modified="2011-10-19" version="1">MSRFALSALGVTQSVLGFTHSSLIRQESSASATCSNPQLSCQNSSAVTDTCCFNSPGGALLQTQFWDTNPATGPDDSWTIHGLWPDNCDGTYEANCDDRRAYTNITDILKTYGRQDLVDYMNTYWTSNSGSAESFWEHEWGKHGTCVSTLDPDCYTSYQPTEEVPAFFNRTVDLFKSLPSYTWLSAAGITPSSSKTYSLSAIQNALADKFDGHAPYVGCRSGQLDELWYFYNIRGSLQTGDFVPTDSLTKSNCPSTGIKYLPKSSGSSPTSTGTSAPGSSPTSSPGGPFSGSGYLNVITGGSQKGCIISSGTWYTSGTCATFTATSSGDGFTLKSSKGACGIVSGALTCGSGVSSTIFTADGNSLQYGGGTAFSADSTASGSTQVKVYAGSGHPTGLTVEWQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMY3</accession>
    <name>F9XMY3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_106107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848635.1">
        <property type="nucleotide sequence ID" value="XM_003848587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMY3"/>
    <dbReference type="STRING" id="336722.F9XMY3"/>
    <dbReference type="GeneID" id="13396136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106107"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.211"/>
    <dbReference type="eggNOG" id="ENOG502SW8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097220_3_0_1"/>
    <dbReference type="InParanoid" id="F9XMY3"/>
    <dbReference type="OMA" id="PDMHRTI"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="15070" checksum="01CD5918C3AA5FDC" modified="2011-10-19" version="1">MAHPIKTTTNLTPTSPLLALPPPGTFDILPTLHELLSRVALQQTDPNLHTANSNLSDSVPEGTSYIGLAPLAPKDLPTAVLEVKAKIRAALRAVEGLPDVERSLEEQDEEIAELEERIRRQRIVLGGLQEVKDGKVGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN87</accession>
    <name>F9XN87_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_10540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
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                <person name="Kuzniar A."/>
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                <person name="Rudd J.J."/>
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                <person name="Shapiro H."/>
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            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Lombard V."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847863.1">
        <property type="nucleotide sequence ID" value="XM_003847815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPG8"/>
    <dbReference type="GeneID" id="13401503"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96910"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.50"/>
    <dbReference type="eggNOG" id="ENOG502R997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115969_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPG8"/>
    <dbReference type="OMA" id="ATINCVI"/>
    <dbReference type="OrthoDB" id="3637047at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390985" evidence="1">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="152" mass="15486" checksum="656F69D9F8932826" modified="2011-10-19" version="1">MKTFFALAASVATTFAAPGQWDAAAPKCTDGGQLHCCQATFTGAAAPVTLAADLACYDLTPAVLNCVITDAPIDPDFGCVGEYACCQVNELNPLLGLFCSKPPGDCRGREGGSPAYCTDVIDGRFGNCTDNDVKNNQGLLGIGDGLLGGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPH1</accession>
    <name>F9XPH1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_77210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847865.1">
        <property type="nucleotide sequence ID" value="XM_003847817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPH1"/>
    <dbReference type="STRING" id="336722.F9XPH1"/>
    <dbReference type="GeneID" id="13401505"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77210"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.53"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPH1"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="291"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="463" mass="51442" checksum="494C1DACE228274B" modified="2011-10-19" version="1">MAAKRTALRILRAGFARRRPVVHRSFSAAIPCRTDGVFTALTNERVQIPWVEAFRKEQAEKATGGKADGGGQQQTTKVERDLTPRKMSDSYHSVILPLAQDPWLLDTYMNATGQIRIGQLLMDLDALSGVVAYNHTGDGVSTVTAACDRITILNPLTEICDLEYSGQVTYAAGRSSMEITLQVAKAPKDGVKAKSEDVMMICQFTMVSLDPATKKPVNIPAVRTDTEEEKRLFSEGEKNSKLRKALLQRSLLKQTPNDEESDLIHAIWQKQLQYHDPNDPLRQPANVVAMEATKLSTASIMQPINRNRHQFMIFGGFLLKQTFELAFCCAASFAHARPTFVSLDPSTFQNPVPVGSVLYLTATVVYTDPPVVTGEADAPSSTEAGRTRVQVRVDTKVRDVEHGQAKPTGQFNYTFTVERGIQVMPKTYSEFMMYVDARRRAKKVVESMKDGETDDGRGERMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPH5</accession>
    <name>F9XPH5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_50710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848224.1">
        <property type="nucleotide sequence ID" value="XM_003848176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPH5"/>
    <dbReference type="STRING" id="336722.F9XPH5"/>
    <dbReference type="GeneID" id="13401812"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50710"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_18_0_1"/>
    <dbReference type="InParanoid" id="F9XPH5"/>
    <dbReference type="OMA" id="SICWRTT"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="69" mass="8085" checksum="9DEFF64AB2FC91ED" modified="2011-10-19" version="1" fragment="single">MAPLATEDYYLLLGVEHTATLDEITKSYRRLSLKLHPDRNKQPNATSEFQRLGLAHETLRDPTQRREYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPW7</accession>
    <name>F9XPW7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_77764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847564.1">
        <property type="nucleotide sequence ID" value="XM_003847516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPW7"/>
    <dbReference type="FunCoup" id="F9XPW7">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="GeneID" id="13401202"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77764"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.132"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_0_1"/>
    <dbReference type="InParanoid" id="F9XPW7"/>
    <dbReference type="OMA" id="EEPRGWW"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="289" mass="30879" checksum="F5C2B0397EDD72C6" modified="2011-10-19" version="1">MATSSPKATLKILMLHGYTQSGHLFAIKTKALKKSLEKAFPAAPKPGHLTQYPGGVELVYPTGPLKLNPAELPGADLDGAADDTDSEAYGWWRRKDVGPGSEPLYADLDSGLRVIAETLKNDGPFAGVIGFSQGGAAAALVASLLDEGRVEAFQRLEKSGSGMPYPPEFLDPSTGKQIHPPLKFAASYSGFRPGHPQYEAFFTPKIQTRMCHFVGSVDTVVSEERVLALAKGSEEGKGRVVYHPGGHFLPASQKQTVAALIGFVREVVEGGGGDAKEEEERAEDMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ43</accession>
    <name>F9XQ43_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_101874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847745.1">
        <property type="nucleotide sequence ID" value="XM_003847697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ43"/>
    <dbReference type="GeneID" id="13401017"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101874"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.216"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="F9XQ43"/>
    <dbReference type="OMA" id="NMGSINW"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF13">
        <property type="entry name" value="2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="261" mass="27892" checksum="95B979593B68B7D7" modified="2011-10-19" version="1">MPEYATYPSLRGKKVLVTGGAEGIGAAAILAFAAQGAQTIILDISTESATALIEQIRSLGHPIPDFHQCDVTDLSRLKAIADEVLAKHGAVDVLVNNAASAGGLARAATDEVTPEIWDFNIAVNLRHQFFLSQYLAPAMRKQKSGSIINMGSITWRIPAVGLPVYTTCKAAVLGLTRTHAKEFGVDGVRVNSIMPGSIATERQKKEVLTKEYEAWTMEAQMIKRVLVPEEVARVILFLASDDASGVTGSSYVVDGGWVGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ60</accession>
    <name>F9XQ60_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_12260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="395"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="246"/>
        </location>
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            <begin position="581"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
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            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="171"/>
            <end position="184"/>
        </location>
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            <begin position="219"/>
            <end position="234"/>
        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="602" mass="65944" checksum="F94F4AFB806C7493" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQN3</accession>
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        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6498" checksum="6F32F7DB7F1BCA01" modified="2011-10-19" version="1" fragment="single">ENVYNMDETGVMLSMLGSVKVLIGKDDLRDYRGTGIKRTMVIAIKCISANSRALLPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR38</accession>
    <name>F9XR38_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13539" checksum="F8C028721131C1EA" modified="2011-10-19" version="1">MSSTLKKAVKEIFEEISKTKSNLKRVLTMSESGAGQRVFPPRTSKNDEKFGLRLDKGEPVQGKPGFIRLNLQANSNAKNNTIREMAQKDSHRVLASIDIDTKQEANKENASKLRDQLIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR81</accession>
    <name>F9XR81_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97740</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847280.1">
        <property type="nucleotide sequence ID" value="XM_003847232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR81"/>
    <dbReference type="STRING" id="336722.F9XR81"/>
    <dbReference type="GeneID" id="13399935"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97740"/>
    <dbReference type="HOGENOM" id="CLU_1856868_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR81"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="16147" checksum="FFA705373657F2BC" modified="2011-10-19" version="1">MPAGSNLRTHRLDLREDPQRCPLTPHYRSVSFKRYSALPREVRRKLRYPYTRMRETAAFGLLVRQFERTSGQPPSDLGRCRDAMDRCFQLLCALQDCRAQGVFHGDIKSETPSTFLYFSSFRFLFQLAGWVAVTYVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRA5</accession>
    <name>F9XRA5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847246.1">
        <property type="nucleotide sequence ID" value="XM_003847198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRA5"/>
    <dbReference type="GeneID" id="13399920"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97761"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.78"/>
    <dbReference type="HOGENOM" id="CLU_1939768_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRA5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="130" mass="14077" checksum="7B4A4EED2BE5AF98" modified="2011-10-19" version="1">MATGIQKKLLNASHGLNIDSSFRDFPRLPFPACVPVPDADGEERVQDSWPTIAAFSLGYVRSPESIDVDRGRSSDRTRLPPIPNSSITATTATAPAKDGEGTARRRVYKILCGMTRSCTQQKAEVRKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRK3</accession>
    <name>F9XRK3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847175.1">
        <property type="nucleotide sequence ID" value="XM_003847127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRK3"/>
    <dbReference type="GeneID" id="13399677"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111767"/>
    <dbReference type="HOGENOM" id="CLU_1220531_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRK3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="227" mass="25909" checksum="9E08371715141C13" modified="2011-10-19" version="1">MRDRKPAFQRRSQKLNSRSGASSGGHHNFINCGVFTILNAAFIEDEPTDAPVDAAVVRYLLAAIVAVRYALPFEELPETCLAHLPEVQSVSETLDIPNIYRRIRQLRQQRDQRRIELGKHCQALNVQRTTLALFEGWLSRQRPPPGSGVETRHAVGTLANITTKHELDLVASTLGVNPKTLRDRMKDLGDRLEANNRRTQQKTEEYRKVLEMHTSMRLTVEQRREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRW4</accession>
    <name>F9XRW4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847011.1">
        <property type="nucleotide sequence ID" value="XM_003846963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRW4"/>
    <dbReference type="GeneID" id="13399256"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111789"/>
    <dbReference type="HOGENOM" id="CLU_2160408_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRW4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="111" mass="12769" checksum="FAE0AE09AD3D3FC7" modified="2011-10-19" version="1">MIRFWTLLQTRLRLRIRLHILRRTPPLSHPPPPQSPPPPNSVDRARTELTVHLDDKHALDCYDVLLRAYRASPLYEPDSKEDPYARIEILEATLAHLDTAVCGRAEELSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS52</accession>
    <name>F9XS52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_98042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Aerts A."/>
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                <person name="Bristow J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856089.1">
        <property type="nucleotide sequence ID" value="XM_003856041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWC4"/>
    <dbReference type="STRING" id="336722.F9WWC4"/>
    <dbReference type="GeneID" id="13394342"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102206"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784260_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWC4"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="35921" checksum="76F6CF019FF798E7" modified="2011-10-19" version="1" fragment="single">MPSQAAHMSNAHLAMKGFAIDYHNSDDFASDFAPSRQSMSSYGNDSPATPQSGAGENDNSKNYNNGNGNGNEYRTPNPNVQLFRTESEAFRDELYNPNVTFTNPVTAKQPTSNSYLSPNSNLITQRLQTANLARSTSPSGLGRERSPFRDNSPMASDWRTPAVAPVTTAASIRRQQNDSAVAAELGKQRVPLRREPTKTISPKDALLDYTHDPDQTPLFQDSAPAGYEKHGAAAEQWPVTNFLNQQTPAFNGQQNMGFRNASSAENGFSNTAFNFPSLPQADEIQNAFQVNYPSTASASLKNYSEPAPAFPASIPSMETSISDAGPPASSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWQ6</accession>
    <name>F9WWQ6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_33249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856491.1">
        <property type="nucleotide sequence ID" value="XM_003856443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWQ6"/>
    <dbReference type="STRING" id="336722.F9WWQ6"/>
    <dbReference type="GeneID" id="13395124"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33249"/>
    <dbReference type="eggNOG" id="ENOG502SGIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761206_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWQ6"/>
    <dbReference type="OMA" id="GRADINM"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="364" mass="42739" checksum="08BC5E6CA024206D" modified="2011-10-19" version="1">MSVSTHPPDWLRRYGNLQGYSWRPTTINGRSAFCRPLGLVEFSFDTDGRHYEGRADMNVCIKTELATTLSKADLRERILLAWTRLRNQHLLLRAKTIRDESDSLAPQGLHFAVTVPESWQQARIEDEKQIVWLEDHYENIEWKDFYHHCQNIWDGLSSYVWMRDFVHCLNETSSNLQDEITTYIQPESIRQRLPLPQEALYPPIPGNVARQRWFWAITRILRHVRTPLPAGFENPLRQEGGVRKQAIRFEQKYAAVLDYSAVPPLNTTTLHVAIPSSRYSRRQSSFIPARQLTSVFHTQRKASLRPLQIHFHNPRRWNLRPRRPNHDGGPRKLLLLFFLPSGQTLHNRLSPQPARFFQPPHRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX85</accession>
    <name>F9WX85_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_24762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856805.1">
        <property type="nucleotide sequence ID" value="XM_003856757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX85"/>
    <dbReference type="STRING" id="336722.F9WX85"/>
    <dbReference type="GeneID" id="13398515"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24762"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_1_1_1"/>
    <dbReference type="InParanoid" id="F9WX85"/>
    <dbReference type="OMA" id="RIVLCMV"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="293"/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857282.1">
        <property type="nucleotide sequence ID" value="XM_003857234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY38"/>
    <dbReference type="GeneID" id="13402853"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102552"/>
    <dbReference type="HOGENOM" id="CLU_1939762_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY38"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="130" mass="13935" checksum="FE7D2D06B8D2A628" modified="2011-10-19" version="1">MLSTFPRNASPTTLPRSDLVIPAVLFLDSILVDLNPLSASWVYPHGLLIRAAAWAILGGVLTIKVGVQGLLDVKNAKRRTAWLVAGLLVLAQVCERSVEDHGGREILLAQVRDADTLATHWTSTADGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYA0</accession>
    <name>F9WYA0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_66809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857101.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9WYA0"/>
    <dbReference type="GeneID" id="13395240"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1453"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9WYA0"/>
    <dbReference type="OMA" id="DFNRHEH"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36325" checksum="761F6511E4AEA320" modified="2011-10-19" version="1">MELYLIRHGETVDNVGGLYAGVRDSALTIHGVEQARHLGQHLAGRGVIFDRIFASTLSRAFKTAKAIQTAQPDPAAGSDESAIVRSVEVIQVSQLIEQNFGFAEGMSFQTRTDANKTGREAYRDRHKDDPGFVDVESKESIDKRADIFLNEHLLPLFELPSKTRPRAVAVVSHGILLSHLWRRLLLRLPPKSVTVAPEVTALRGTLVLQHLGGWSNTGYLQLAMTKDEQHIVPIKLDASSPRPPVPADTIEAVTDEPLRTEQGKDNAGPGDAVRERPSRMIFGWSTTIVAVDRKDHLVGLKRQRGGIGRSAHDESQKKLTGFFKKQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD3</accession>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="13398837"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31519"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1663"/>
    <dbReference type="eggNOG" id="KOG1399">
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    </dbReference>
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    <dbReference type="InParanoid" id="F9WYD3"/>
    <dbReference type="OMA" id="NYFQTFN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61644" checksum="E38E0B35E051A0B8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD4</accession>
    <name>F9WYD4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856627.1">
        <property type="nucleotide sequence ID" value="XM_003856579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYD4"/>
    <dbReference type="STRING" id="336722.F9WYD4"/>
    <dbReference type="GeneID" id="13398836"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107596"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1665"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038379_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYD4"/>
    <dbReference type="OMA" id="LYPFCVK"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="295" mass="31720" checksum="2EE56100427B6259" modified="2011-10-19" version="1">MSSGSSANRSNKKSSPGGKRPPLTHFLCVPLVTPASESQLQTSLKTFRGEVSPSSPSENITAARGAHASPQTPAAIPTIPHAAIRPVGTLHCTLGVMSLDQNQLAAAIELLQSCEVTKLFEDSATTGGLDSSPLTIELKGLVSMHAPQSTSILYAEPVDSSQRLYPFCVALQALFRSKGFLIPNDRSLKLHATIINTIYAKGNRKSTRQKLDSTVPGPAAEKLEDRSRGHGPNAKAPIKLDARPLIEKYEDFLWAKNIVLDRIAICEMGAKKVHDAQGNVVEEKYTEVAHVELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD9</accession>
    <name>F9WYD9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_17581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857047.1">
        <property type="nucleotide sequence ID" value="XM_003856999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYD9"/>
    <dbReference type="STRING" id="336722.F9WYD9"/>
    <dbReference type="GeneID" id="13395415"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17581"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071320_1_0_1"/>
    <dbReference type="InParanoid" id="F9WYD9"/>
    <dbReference type="OMA" id="DHADHNH"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21254" checksum="864EA38E7C6BE806" modified="2011-10-19" version="1" fragment="single">LYAEHLVNIRTLSIAASLDTETTKDTKAVLAPDGASLFLTHEGHTARIDLPVSVPSGHNKAAFTLPSAPTKQLSFRIQLDEKSRDHPENGEVNRVDGDIVPWTAVSLTSGTELCCNSCNAVLLARDKIRIWKDLPSENWAEMMDFWHCHRPDVPKDHDHKIPLKGYSAESRLAIQAGVGMVDPVDFVFAADDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYV6</accession>
    <name>F9WYV6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_88944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857629.1">
        <property type="nucleotide sequence ID" value="XM_003857581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYV6"/>
    <dbReference type="GeneID" id="13403968"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88944"/>
    <dbReference type="HOGENOM" id="CLU_685523_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYV6"/>
    <dbReference type="OMA" id="CPAANTI"/>
    <dbReference type="OrthoDB" id="10520449at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391135" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="40964" checksum="32DA90D143C4162C" modified="2011-10-19" version="1">MVSLKAAVFVFTLSLGIGSHATSIASWSNHTAVQITKTLPSVGSTTVGDATVTDFPASMANSETLSSGTSSLPASNSSNTQEMVSSSMSGFTAISSESVLSTSISNVSALQQASDSFWGAMVPTSSFSSISILISSDVSLLLTASSSSMSVPAPTSDTVSSTASTGSDASSSSGTAIDFTTQQTDSSISEQATTYANSSSAVVSSTTSLAEVWTTVPLVIPVPSSAFSNAATTFSSNPVLQATSQMPTSVDAVAPSSVASTITMTTFVTTRTVGYQETSFVTITVSTPPATAVLTKREVCTAPGGLLYDCGPVPPKAEPIEWWADKEAVAEILDFLEHLWAHMPPPAQQVAVVPAKRDVCTTNGLLFDCGTPTKPTPTPDAAAAAAAAIMSILQNLPPSPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZB4</accession>
    <name>F9WZB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_83894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857257.1">
        <property type="nucleotide sequence ID" value="XM_003857209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZB4"/>
    <dbReference type="FunCoup" id="F9WZB4">
        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="GeneID" id="13402828"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83894"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1218"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="F9WZB4"/>
    <dbReference type="OMA" id="TTRFGAY"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP92233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32741" checksum="EB33F38FD0255258" modified="2011-10-19" version="1">MAATKTTVKSEAVHNGAIHYPLWFGGSASCLAACVTHPLDLLKVRLQTQAHGAGRQGMLAMTGSIVKADGVPGLYRGLTASLLRQITYSTTRFGVYEKLKEIFSDGVNQPSLPALIAMASTSGWLGGMAGTPADILNVRMQNDAGLPAAERRNYKNAIDGLLRMVREEGFGSIFRGIWPNSSRAVLMTASQLATYDVFKRELLKRTNMGDSLTTHFSASLMAGFVATTVCSPVDVIKTRIMSASTKDGFIPLVKRITASEGIGWVFKGWVPSFIRLGPHTIATFLFLEQHKKLYRSIKGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZT9</accession>
    <name>F9WZT9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_98291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857593.1">
        <property type="nucleotide sequence ID" value="XM_003857545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZT9"/>
    <dbReference type="GeneID" id="13394309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98291"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_2_1"/>
    <dbReference type="InParanoid" id="F9WZT9"/>
    <dbReference type="OMA" id="TCAGIQV"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000811">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="495" mass="55353" checksum="D88D524D9DE27B44" modified="2011-10-19" version="1">MTDVGSHHFVKGGSQVLVPQPSDDKHDPLNWSLKWKTMCIIASTMVSFTQGFGPLALAPMFPYYMKDFNASLEEVIDFTGVVILVLGFSNFIWVPISTSCGRRPVLIFSQLICFASSIWRAKATTYSSFMGATILNGIGAGPSETIQPAVIADIFFLHDRGFWNTVYWVAYMGSLMVGPIISGSMSLHIGWRSFWWLNTGVVGLSILMVVFMFPETKYHRPHPNEIIDSTSSQENLTADRDPWLGKGSPSWGQWGIYAPSPNPLRAVFLDFWVPWKLFAFPIVEFSSFVVSWSCSCFLTINLTQSQNFAAPPYNFNSERIGFMNFAILIGAFIGLGTAGPLSDWVSARATRKNRGIREPEMRLPSMIPYVAIMILGNFVVAYGYENKWHWAIIVVIGYACAGIQVAALPAMATTYAVDSYKPVSGSLMVSITVNKNLWGYGFSKFLTPWIVKSGYVPPIMTNMSLTTLWCLFGVAFYFFGKHCRRWSKHSSVHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0P0</accession>
    <name>F9X0P0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_84245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856947.1">
        <property type="nucleotide sequence ID" value="XM_003856899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0P0"/>
    <dbReference type="STRING" id="336722.F9X0P0"/>
    <dbReference type="GeneID" id="13398658"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84245"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="F9X0P0"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="503" mass="54685" checksum="E5A390E1CF39FF91" modified="2011-10-19" version="1">MADKQVPFDSVERHSSSDHTDKKTTHKATTTDLPPLAATGKTRWERSWPTIACGAGLFSDGYLQAVIGPVNTILKSLYGDAYTKSSARQNVTSIAFAGTVVGQLVFGYTSDHYSRKWSLFISTVILFVFAALGAGSYGAGGSVQGLFAALTAYRFLLGIGIGGEYPAGSVGAAESTALLTSTNSTQIDLGFVIGTLVPMIITRAAPDNLTLVWRLSLALGVIPPLSLLYLRLKLNEPESFSRESFKRTKTPYYLALKFYGPRLLLVCGIWFIYDFLTYPFSIYSSAWIDVIQPDAALWQTFGWACLVNLFYLPGAIFGSFTSDWMGPRKALFVFVIAQGVLGFIMSGCYEYLKMPKNIAGFVVVYGVFLMLGEMGPGDNIGLVASKTCATGIRGQYYAIAAAMGKIGGFIGNYIFPYIQDAGGSSVVRQGQYPFYVASSLCFVSALLVWLLPEINQDTIEKEDIEFRKYLELHGFDTSAMGLGVLPERSQSIVGKVDSKEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0P9</accession>
    <name>F9X0P9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_54325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856741.1">
        <property type="nucleotide sequence ID" value="XM_003856693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0P9"/>
    <dbReference type="STRING" id="336722.F9X0P9"/>
    <dbReference type="GeneID" id="13398577"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54325"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="F9X0P9"/>
    <dbReference type="OMA" id="LYGDPQT"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Nap J.P.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </feature>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857109.1">
        <property type="nucleotide sequence ID" value="XM_003857061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1A7"/>
    <dbReference type="GeneID" id="13398972"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78911"/>
    <dbReference type="HOGENOM" id="CLU_2783047_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1A7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="69" mass="7338" checksum="0C8264A25CD8A204" modified="2011-10-19" version="1" fragment="single">MLPQTASHDAHFCPEELESLESGPLHTGFTSLFIDAPGTESSMHQSSEGPRQDQKSVARLVDLGTASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A1</accession>
    <name>F9X2A1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_84586</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855586.1">
        <property type="nucleotide sequence ID" value="XM_003855538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A1"/>
    <dbReference type="STRING" id="336722.F9X2A1"/>
    <dbReference type="GeneID" id="13403526"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84586"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.507"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="InParanoid" id="F9X2A1"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP90562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="181" mass="20883" checksum="7C9368770547FB95" modified="2011-10-19" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKKIMNEDVNSVSPTLGFIIKTIDYEGYKLNIWDVGGQKTLRTYWKNYFEKTDTLIWVVDATDRERVDDCRQELKGLLVQERLMGASLLVFKNKSDVPGCMSEDDIRKGLQLDSILTHKWHILPCSAMTGLNLQEGLQWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J1</accession>
    <name>F9X2J1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_107828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Koopmann E."/>
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                <person name="Lombard V."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395483" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="53" mass="5724" checksum="5E2AE401C0A7A6DA" modified="2011-10-19" version="1">MNFSLQLICLVATLFAGQTFGAVPLQPRANECGGGQFISRDHPDGFARLLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2S0</accession>
    <name>F9X2S0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HCP2401</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_36432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854839.1">
        <property type="nucleotide sequence ID" value="XM_003854791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2S0"/>
    <dbReference type="STRING" id="336722.F9X2S0"/>
    <dbReference type="GeneID" id="13403608"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36432"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.337"/>
    <dbReference type="eggNOG" id="KOG3391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X2S0"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="28683" checksum="399C61AE9B719B01" modified="2011-10-19" version="1">MASLRPEAGTTIDRATTAPFLLRLYWRQNRQLDPWEFSVAVPSDTTNIPDYSSLLPRDVKGHMMQIYTWPNCTLAELTTLFLSVLPENVIPNPAVGTRLVFKLIFPDTRATIAEGGRGKFIDKPLGSVVIGGSRAEMADDGAENGDVTETFEGDAHKTLAEARFVIGDYVACSVYPPDQDGRVAPMPPPTSRGGFGGPRGGPPRENGFGGGYGRGGGGGYRGGYGGRGGGGYGAPPPSGDWRRGERPPEGGYDDRRGGGGYRDRGGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X363</accession>
    <name>F9X363_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_36120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855138.1">
        <property type="nucleotide sequence ID" value="XM_003855090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X363"/>
    <dbReference type="FunCoup" id="F9X363">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="13400734"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36120"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1012"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X363"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29583" checksum="C362DD196BE53A33" modified="2011-10-19" version="1">MAQLVGKYAANKLLKKQMAKYESKKVTGGEDPYFAMIEDPRKPGKLKKVKKQVPSYIPEHDAAILASVRRRAYHLDCSLFSLFGMRFGWESVIGIIPVAGDVIGVALALMIVKKARTIEGGLAQGVLIQMLINVALDFLVGLIPFLGDLADAAFKANTKNLRLLEEVLDKKYKPSELKTDPRNTPGLDPQTRKQNRKSGIYHPMDPPPATAWEDSDVEEEYRPHGNGVQAAPAGGRQPGFGPGGQAAPMMDGANRAPPQDRRAQQSQPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3C4</accession>
    <name>F9X3C4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_26025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855766.1">
        <property type="nucleotide sequence ID" value="XM_003855718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3C4"/>
    <dbReference type="STRING" id="336722.F9X3C4"/>
    <dbReference type="GeneID" id="13403706"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26025"/>
    <dbReference type="eggNOG" id="ENOG502QWJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3C4"/>
    <dbReference type="OMA" id="HNKGAQK"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="309" mass="35121" checksum="AF137BE478C27C24" modified="2011-10-19" version="1" fragment="single">SSTTLSFTSQLSSLIGSSTTKDNSKPAPARSRPRKKDDIFTTHNRNTAKRAKRDLEADVSGTFAQKHTTNGEALGKDVWERSKRKMEEKARLYAAMKRGDVEDADERYAVDFDTKWAEARAEGREDSSSDNGSEDGDTPQEEVEYIDEFGRTRKGTKLDALRARTAIDRANNAPPADDRFTARPVAPSSVIYGDTIQHQAFDPDEPRAAQMAELAKKRDRSLTPPPEEHFDGRKEVRTKGTGFFQFDADESVRKEQMAGLERERAETEKMRKERESKLGERRALIEKRREEVRERNSRRKAEEFLEGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3N1</accession>
    <name>F9X3N1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_90773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855538.1">
        <property type="nucleotide sequence ID" value="XM_003855490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3N1"/>
    <dbReference type="STRING" id="336722.F9X3N1"/>
    <dbReference type="GeneID" id="13399593"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90773"/>
    <dbReference type="eggNOG" id="ENOG502SCDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897742_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3N1"/>
    <dbReference type="OMA" id="YYFCPKL"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="310" mass="33760" checksum="639B0FD863AFD598" modified="2011-10-19" version="1">MPAKTRAKPSAAKAKKSEAIKISTTLKTLPPSEDSPPLLCVLPKDASPEAKFVSLRNPASKEGTSRYFVCPKKGFFELVKVGGSKQEACRSWIVASRGVEEEEEEATSQEQDTRVDSQQQSQVSQQDKEQDESTESDGYILSSPSLLLATPLDPLFLLLPQLTASSQSNPSAKEYLAPSDYISLLTTSSPHLTSLISASPHLTRILEVRIEAVSDVMDMGDGDKMYAFSRDKLAGVLVEKARRMVGGEGGLPRSLEARFVKGVLDVPVLGERREGQGEARRRMLKPPHLPQRAPQTPVPRPKYSPSCACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Y1</accession>
    <name>F9X3Y1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_36524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855405.1">
        <property type="nucleotide sequence ID" value="XM_003855357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Y1"/>
    <dbReference type="FunCoup" id="F9X3Y1">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3Y1"/>
    <dbReference type="GeneID" id="13400952"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36524"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="InParanoid" id="F9X3Y1"/>
    <dbReference type="OMA" id="GLMCAFD"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="490" mass="53781" checksum="AF026E4569A86BED" modified="2011-10-19" version="1">MATKTPARNASAAAAVQSVKSAVGLEQPLFPGEPDAPTVRTEIPGPISKEAIIALDKVFDTRSLNMMANYQNSYGNYLADLDGNVLLDVYAQIASIPIGYSNPALLAAATSPEMASAIINRPALGNFPQHDWAEILETGMLKVAPKGCDQVFTAQAGSDANELAYKAAFMYKRRQQRGGPDVDFTADEISSAMNNQSPGAPNMSIMSFKTAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQASFPALKYPLEDHVEENAREEARCLAEVEEILTTFHSPPAAVVVEPIQSEGGDNHASPAFFQGLREVTRKHDVLLIVDEVQTGVGATGKFWAHDHWNLQDPPDMVTFSKKAQTAGYYFGNPELRPNKPYRQFNTWMGDPARAILFRAIIDEITRLNLVENTAVTGDYLFSGLENLAKKYPGEIQNLRGKGQGTFIAWDSPRRDEVLKKAKSVGINVGGSGEKAVRLRPMLIFQKHHSDIFLEGMEKIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X470</accession>
    <name>F9X470_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_67922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855732.1">
        <property type="nucleotide sequence ID" value="XM_003855684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X470"/>
    <dbReference type="STRING" id="336722.F9X470"/>
    <dbReference type="GeneID" id="13395981"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67922"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.218"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="InParanoid" id="F9X470"/>
    <dbReference type="OMA" id="PILAYWE"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="341" mass="38023" checksum="A888CFADD96CFAB3" modified="2011-10-19" version="1">MDSLQEKYHTTTRNLTYRYYISPSTSTSSGKPTLLLCHGWPDAAELWRFMIPHLLQSGLRMVAPDLLGAGKTSKPVDPKAFEIKAMVEDVKEILTAEGVEKNVIPVGHDWGSYFAQRYYLFNTPQMAGLITLNVALMPTRSEPFNLDAANTMTEKLIGYPMYAYWEFFATVDGPKQMEAHLPSVWHACHGASDAHMLKLFCNRGAMADFITSNQKDPAGLLPYAQDEAFQDAWMATQANGGLQSQNCWYRAHVEGVQDASEKALAEGLGNGKVEKPYLFVGATGDAVCRTDFIEMPKQMGLVPDLEVVELESRHWVPYEKPEEATGVIVSWLKKRGFADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4X2</accession>
    <name>F9X4X2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAM-2, hyphal anastomosis-2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_69142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855208.1">
        <property type="nucleotide sequence ID" value="XM_003855160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4X2"/>
    <dbReference type="FunCoup" id="F9X4X2">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4X2"/>
    <dbReference type="GeneID" id="13400489"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69142"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1206"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4X2"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="550"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116975" checksum="88FEB7DA743333F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X542</accession>
    <name>F9X542_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853836.1">
        <property type="nucleotide sequence ID" value="XM_003853788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X542"/>
    <dbReference type="GeneID" id="13404175"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103733"/>
    <dbReference type="HOGENOM" id="CLU_2672993_0_0_1"/>
    <dbReference type="InParanoid" id="F9X542"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="75" mass="7956" checksum="48AACAA6530C3E4A" modified="2011-10-19" version="1">MRESASPRNPAPCLAMDLRGPRSARSETCSSLLGSSQQVPCTGTPALRLGTLMRHKPFIAGGRRHVDAQAPDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5C0</accession>
    <name>F9X5C0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_37793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854677.1">
        <property type="nucleotide sequence ID" value="XM_003854629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5C0"/>
    <dbReference type="FunCoup" id="F9X5C0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5C0"/>
    <dbReference type="GeneID" id="13395864"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37793"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031301_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5C0"/>
    <dbReference type="OMA" id="LARKDHM"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47894" checksum="A350B39A48432947" modified="2011-10-19" version="1">MIYAIVDYEDKYVQPLLRAAFKSLLPDRLTLINDISELPNKTDKLIQWRQYESIDFDHLISHPSSSLCNSYVIRKALIRKHYLASTASHWLSKHPDSPLKDHIQPSVEFEVDYAEFLDDALVEAYELKESWARNEAIEEGDETSQEWWILKPGMSDRGQGIRLFSSEEELTEIFEDWDPASDDEEEDTTSQTGDDLSEKHDDAGVMASQLRHFVAQPYIMRPLLLPESHPSAGRKFHIRTYVLAVGALKVFVYKPMLALFAGEPYAGPTGSGSPNENLSSHLTNTCLQSGEREGSVHAFWSLPAEVASLDNADWKDDVFKQICRVTGEIFEAAARSMSIHFQPLPNAFEIFGLDFLVDSKGTAWLLEVNAFPDFAQTGPELEGIISDLFHDVFKVGVLPFFDNGGVSSPGSTDNMVKALDIDLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5I4</accession>
    <name>F9X5I4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_103615</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853713.1">
        <property type="nucleotide sequence ID" value="XM_003853665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5I4"/>
    <dbReference type="FunCoup" id="F9X5I4">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5I4"/>
    <dbReference type="GeneID" id="13395737"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103615"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="InParanoid" id="F9X5I4"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="97"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="98"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="37962" checksum="A09271083239A5CF" modified="2011-10-19" version="1">MPPAMSKFTLAVVAGASAAVGAATTAVLYGVGKPKETTTTTTVTSTSTSPSASRTSPPPPAPVALPHDYTKLPLIPPVDPAGVFQYGFPGPVSDIRNAPSLTSSYNRTTRNPHWVAEHITPASLLMQNGDRRHSQFAEDHTIPEKFRAKLKDYFRSGYDRGHQVPAADAKWSQDAMDSTFALSNMCPQVGEGFNRDYWAHLEDFCRRLTSYYPSVRIVTGPLYLPKRDVDGKWKVSYEVVGHPPNVAVPTHFYKIIFAEDGRAGGAVSLGAFVLPNDRIPNDKPLQDFEVPIEALERASGLEFASLLPAARRKKLCQEVSCSIIVKQYAERQRTMMTPPPQNLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X743</accession>
    <name>F9X743_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_108865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854097.1">
        <property type="nucleotide sequence ID" value="XM_003854049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X743"/>
    <dbReference type="GeneID" id="13404534"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108865"/>
    <dbReference type="eggNOG" id="ENOG502QUYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036094_0_1_1"/>
    <dbReference type="InParanoid" id="F9X743"/>
    <dbReference type="OMA" id="NGWVLYK"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="50789" checksum="70E88BB1DE1C6714" modified="2011-10-19" version="1">MESSPSSSSSSSKRPLLSTLKRRANNLHASTPYLRRLPAPALFIVLLLILTQLLVWTCVGIVLSFHPLLVSTSILSYTLGLRHALDADHISAIDLMTRRLVASGQKPVTVGTFFSLGHSTIVIITSIVVAASSAAIESRFGAFGEVGSIIGSSISAAFLLILGGINIYILHRLLIHLRSAIAAPTGQDFALDITFTGGTGCMTSLLQRCFNLIDRPWKMYPLGVLFGLGFDTSSEIALLGLSSIQAAKGTSIWLILIFPILFTSGMCLLDTLDGAAMMSLYTSARLAKDAIAVLYYQCVLTGITVAVAVAIGTLQLLTMIRNVRPEWEGGFWDGVDVAGEHYDVIGGAICGAFLVGGVLAVGIYRPWRRRVEREREKRGLGGEDEAEGEGGEDGESAVGGRCEGGGHGVVEEVVGGTKTAATTAEEVAGKKGVRTERGFTGFSNREDFDMHFQESERIMWFLSTSYIMTLACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F9X753</accession>
    <name>F9X753_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_70478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854189.1">
        <property type="nucleotide sequence ID" value="XM_003854141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X753"/>
    <dbReference type="GeneID" id="13404441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70478"/>
    <dbReference type="eggNOG" id="KOG0203">
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X759</accession>
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            <taxon>Mycosphaerellales</taxon>
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            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13441" checksum="8B1499C6CDB1FCDB" modified="2011-10-19" version="1">MVDQATAPITTARLFHRFYEVIARPFTHGDFQRKNIMVQRLEGDSQHPQLPSWRIHIIDWEKSGWYPTYWDHAMASCALRWDDDWCLWVQKALDPYPSEAAWLQIIRPELWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X783</accession>
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        <name evidence="3" type="ORF">MYCGRDRAFT_38168</name>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP88766.1"/>
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    <dbReference type="RefSeq" id="XP_003853790.1">
        <property type="nucleotide sequence ID" value="XM_003853742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X783"/>
    <dbReference type="FunCoup" id="F9X783">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X783"/>
    <dbReference type="GeneID" id="13395652"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38168"/>
    <dbReference type="eggNOG" id="ENOG502SHAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_9_1_1"/>
    <dbReference type="InParanoid" id="F9X783"/>
    <dbReference type="OMA" id="RRHTHFF"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="556" mass="64108" checksum="73D95D1DC85670ED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Y0</accession>
    <name>F9X7Y0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acc1 acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ACC1</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_70199</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853979.1">
        <property type="nucleotide sequence ID" value="XM_003853931.1"/>
    </dbReference>
    <dbReference type="SMR" id="F9X7Y0"/>
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        <property type="interactions" value="762"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70199"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="InParanoid" id="F9X7Y0"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="51"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="208"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1512"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1858"/>
            <end position="2173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2269" mass="251829" checksum="1062A977C6FA02AA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X854</accession>
    <name>F9X854_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_21368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="6">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853581.1">
        <property type="nucleotide sequence ID" value="XM_003853533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X854"/>
    <dbReference type="STRING" id="336722.F9X854"/>
    <dbReference type="GeneID" id="13397146"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21368"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_6_1_1"/>
    <dbReference type="InParanoid" id="F9X854"/>
    <dbReference type="OMA" id="KFWRCGP"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="471"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="570" mass="64960" checksum="84D89A9AC75C5D7D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8B7</accession>
    <name>F9X8B7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_104090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852913.1">
        <property type="nucleotide sequence ID" value="XM_003852865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8B7"/>
    <dbReference type="FunCoup" id="F9X8B7">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8B7"/>
    <dbReference type="GeneID" id="13400620"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104090"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.259"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="InParanoid" id="F9X8B7"/>
    <dbReference type="OMA" id="PVKSHHG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="295"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
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            <begin position="62"/>
            <end position="231"/>
        </location>
    </feature>
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            <begin position="259"/>
            <end position="284"/>
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    </feature>
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            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
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            <begin position="89"/>
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            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
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            <end position="214"/>
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    </feature>
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        <location>
            <begin position="603"/>
            <end position="617"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="617" mass="66032" checksum="1B15A0786CDD425F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X903</accession>
    <name>F9X903_ZYMTI</name>
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        <submittedName>
            <fullName evidence="14">FRE ferric reductase-like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_70987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
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        <property type="nucleotide sequence ID" value="XM_003853415.1"/>
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    <dbReference type="OMA" id="NIYHRWV"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="633" mass="70166" checksum="A713FE826EE63AE1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9H2</accession>
    <name>F9X9H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_71002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="303" mass="33673" checksum="B8F713CE4AF0D9EB" modified="2011-10-19" version="1">MPDSVLVLGLGELGVEVVKSLATHPARRETKIAVLLRSKKPEQLEQLRQWNVKAVYGNVEDDTEEQLAVSFEPYHTLICCTGMYLPPSTQIKIAKAVLAAGVKRYFPWQFGIDYDVIGRNSSQDLFNSQLDVRELLRGQSSTRHAIISTGMFISFLFEPSFGLVSAERDTVTAIGSWENEITVTSPEDIGKITAEIALAHPDLAGVVYVSGDTISMQRLADVVEQSTGKKVTRQLKSVSDLKQELTEDPNDSMRNYRVVFGEGVGVSWSKAASFNEKQGMNTQTVADWADQHLRSLCCHSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9P3</accession>
    <name>F9X9P3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">MYCGRDRAFT_71341</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X9P3"/>
    <dbReference type="GeneID" id="13400008"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71341"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9X9P3"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
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    </dbReference>
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        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="625"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
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            <end position="161"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP88316.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="950" mass="106636" checksum="47EB496DAA5016CC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9U2</accession>
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            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">MYCGRDRAFT_117760</name>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9U2"/>
    <dbReference type="GeneID" id="13399553"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117760"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.887"/>
    <dbReference type="eggNOG" id="KOG0254">
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    </dbReference>
    <dbReference type="InParanoid" id="F9X9U2"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="574" mass="61385" checksum="30C681010E21241D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9W6</accession>
    <name>F9X9W6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="11">L-Arabinitol 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgLAD2</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_57491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9X9W6"/>
    <dbReference type="GeneID" id="13400876"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57491"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="F9X9W6"/>
    <dbReference type="OMA" id="IPFMHIS"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="368" mass="39514" checksum="D6A75506387454FD" modified="2011-10-19" version="1" fragment="single">MATNGINAAPAFAMNKPNPALYTDEKRQIFMNDSPELQPGPNDCVVRMRCNGICGSDVHFWHTGCIGPLTVTAPHVLGHEGSGSVVWAGSNVTHLLPGDRVAIEPGVPCSTCYQCTSGNYNLCADVAFSGVPPFSGSIRRWHVHPAAFLHKIPDELSFSDGALLEPLSVVLHGFERSPIKLGESTVICGAGPIGMCALAVAKASGAAPIVITDLDAGRLEFATEFAPGCIPYQIVPGVSAQDTAVDILQTMQKAGGDQPRVVYECTGVQGSVVTSCYLPRPAGEVMVIGVGRPIMNEMPFMHMSLAEVDLKFINRYHHSWPMAIRLLQHKVIDLQPLVTHRYKLEEAQKALEASADRNSGSIKIHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAC5</accession>
    <name>F9XAC5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853277.1">
        <property type="nucleotide sequence ID" value="XM_003853229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAC5"/>
    <dbReference type="GeneID" id="13399330"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92796"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.711"/>
    <dbReference type="HOGENOM" id="CLU_627322_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAC5"/>
    <dbReference type="OMA" id="QCRCAKR"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="437" mass="51030" checksum="B4F5728F08024210" modified="2011-10-19" version="1">MKTLVLTHRDRRTHANFLALPPEVRLRCYEYMLIPPLPIHALRHQPTCHNHNPLAASIPPPYIPALQNRPKPASWRSLLPREVLSEKCRISCIQQSGQRRNLAILRVSRLVYKEAIEILWEDEKWGFTFTGLQDFVDSMKTMPLEGRSRVRKLVVREDRNMDVQRRGFGLKEWLHAEFWRFVGGCPRLKYLEVPSTMGGVLAGEVVKLGSLEVVSVSVVGWMTFVEGMDVHRVEIGVKKGFKIRSGEIARNRREMKMEEWLRIADGRRGGRRETPEWMQRVDAALERDRDVMVHQEGGRDWVTVTMAEGMRVEVEIWGLPTHSKAERRKLFLQEARKPKTLKVSRRTVPDLPELGGENDEELAMMAKKSDQRAKIWYEQEEDHEALLEERRDQKKQEAKTERTKEKQKERRKMKRSEKQLAAEKKAVATRAGRREVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB58</accession>
    <name>F9XB58_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_100367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852425.1">
        <property type="nucleotide sequence ID" value="XM_003852377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB58"/>
    <dbReference type="FunCoup" id="F9XB58">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB58"/>
    <dbReference type="GeneID" id="13394202"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100367"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.810"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="InParanoid" id="F9XB58"/>
    <dbReference type="OMA" id="FMPGEPF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="157"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="556" mass="61864" checksum="706726A0895F633A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM5</accession>
    <name>F9XBM5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_93127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852688.1">
        <property type="nucleotide sequence ID" value="XM_003852640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBM5"/>
    <dbReference type="STRING" id="336722.F9XBM5"/>
    <dbReference type="GeneID" id="13393911"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93127"/>
    <dbReference type="eggNOG" id="ENOG502SIPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963802_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBM5"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="289" mass="32051" checksum="5B541E5BC2B9C825" modified="2011-10-19" version="1">MQPDQSRTKHKPIKAGPCTEFGTLVAVNGKLAHDTWARRAVVDPDAPGMRSAYTRAYAGPIWMLRGFRQLRVANAGIGFATLSDGATIRRSIRIGRDDRAVVNMTRSTQSTYTMASTAVHQQLDSGSVPNHVSNVAPAGTKFHLLAVVWLEADEGSVLHGGNTSLHDTKEIPTVNKRRALPILCPHQPPDRGSDTEGHRDLGSYGFIGMQINMPERDGPVHLRPLPCHRNWRDGIPQGWLARDHPAWSRSTHRLNQLERLTKDKVVPSHDETTFLELQVQQNKDGGFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBP2</accession>
    <name>F9XBP2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AvrStb6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Dehal P."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390336" description="AvrStb6" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8123" checksum="08D3522AE87C256E" modified="2011-10-19" version="1">MKPSQLLTAATMLSLPALSLAKYCAGCDYAACYYNGGCINLDPARGRANPGCSPQIIGATCHCDYSGADIHCCTSCPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XBW5"/>
    <dbReference type="GeneID" id="13396993"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71986"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.292"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="InParanoid" id="F9XBW5"/>
    <dbReference type="OMA" id="QVKVERW"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1902600">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
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    </dbReference>
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        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
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    </dbReference>
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        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="93"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="134"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="892" mass="95738" checksum="02E458A99C0989E2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBX0</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Schouten H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
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    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="103" mass="11866" checksum="78D200F035607E14" modified="2011-10-19" version="1">MSRFDRASTDHIEQRFHITMKPSQYLLSAMMLFLPPALALEKKCGGKGNVCYYDGGKSCKTLSTTPFRFKNHHDGDRCYDRVLYWDCECRYADADIHCDATCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCN7</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Ware S.B."/>
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</entry>
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        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="10"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="124"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="576"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="71824" checksum="9F45A8E182230EAD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDT3</accession>
    <name>F9XDT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_73347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851573.1">
        <property type="nucleotide sequence ID" value="XM_003851525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDT3"/>
    <dbReference type="STRING" id="336722.F9XDT3"/>
    <dbReference type="GeneID" id="13401708"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73347"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.514"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="F9XDT3"/>
    <dbReference type="OMA" id="LYAGGWY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="251"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="696" mass="77439" checksum="205E28BC4EA96341" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE38</accession>
    <name>F9XE38_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852000.1">
        <property type="nucleotide sequence ID" value="XM_003851952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE38"/>
    <dbReference type="GeneID" id="13401252"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93617"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.20"/>
    <dbReference type="HOGENOM" id="CLU_892003_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE38"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="34742" checksum="242CF727080CB090" modified="2011-10-19" version="1">MAEAKFRLTQEARREVARRCGAEDMTFETPLYLGEYSADPITAMTQMIDLGSFAQSTKEALLKLGHTDLAELIHDLLTPAYDESMRRADLRLCAKAFKLGVSLAINGDISEFFPSAYPQQLKTDCNNFKVDLFRLLLDLSTDKDVPGPQGKGKQRAISLSVDEQIDEATPEHSSEDEEDAPLPTSKRSKSSLSTASKGKAAKKSTKDWTATHPKLDAVGFDTAVKEVLRIGRQFKSKGITEVAYSRHKAAPDWFDKNSKIYARRADDLLSAIDKNGLYLLPKSEVKNFGDPEKLNRDRLDKSNNAKGVPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEK0</accession>
    <name>F9XEK0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_14552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851686.1">
        <property type="nucleotide sequence ID" value="XM_003851638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEK0"/>
    <dbReference type="FunCoup" id="F9XEK0">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEK0"/>
    <dbReference type="GeneID" id="13401874"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_14552"/>
    <dbReference type="eggNOG" id="KOG0909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031058_0_1_1"/>
    <dbReference type="InParanoid" id="F9XEK0"/>
    <dbReference type="OMA" id="NDFFTWI"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="302" mass="35025" checksum="F840676435CE932B" modified="2011-10-19" version="1" fragment="single">RFRKLLMSLSNSPCNWEDPVLLDAALAKIPLQYIYDQAQAKVDALQAVASLLGKVAKPAWGHQDCVIRALMTWFKRDFFQWVNNPRCPVCESTTTALGMIPPTVGESTRGATRVELFRCSNTMCQAHERFPRYNDAFVLLETRRGRVGEWTTCFTMLCRALGSRVRLVWSAEDHVWTEVYSVHQQRWVHVDVAEGAWDRPTLYTQEWGKKLSYCIAFSVDGCCDVTRRYVRDPDMYGNPRTKCAEEVLWHITREITAMRRTDRDVQELLIIRAEDKREELALQRLAIEALITRMLEEYDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEY7</accession>
    <name>F9XEY7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MgAMN9</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_45066</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
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    <sequence length="661" mass="74496" checksum="6FF098E96C508953" modified="2011-10-19" version="1"> </sequence>
</entry>
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    <accession>F9XF88</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Maliepaard C."/>
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                <person name="Nap J.P.H."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        </source>
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            <dbReference type="EMBL" id="EGP85889.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Maliepaard C."/>
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                <person name="Nap J.P.H."/>
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                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF11470"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="52888" checksum="DBE6FD80ACBC0273" modified="2011-10-19" version="1">MSASHVFVLDSTFKRTQVKVTPGKYLKEVLEEACKARKWNPESYALKTQTNKTVDLSQPFRLSGLSGGAKLTLIQASRSPSVVNVALQLPESEGGGRLSDKFPSTTSLWLVLRKYEDAVAGQPPRKLNLTQRGVPPVGSSGAGQLEYEQPCLHLMGRNMETFGDLQKSFAQLGINDGSVLMRLTFKRNGRLLEEAMKEIEEHFQSVDTVPAGVGSSASQAAPGTHATAPGSLQSLPDADADNAGDDVIASSSITQPGSSTNEEPLNGIAVYLPPSSSTPAAALQEDDPALFEPSIDHAKAHQAALTRMTRNTRLLSDKELAEQEETRQASLAQVNTVTVRVRYPDQSMIETTVSATSTAAELYAQVAGTLASTADAQGKFELRYTGAKGHQTLPDSTSQRLVRDFGFRGKVLVTLIWKPEASAQARQGPSLKEEYRSRAKDLKVELATQQAAGEESHKAAMNKKESGAAASKGKGGGDVEAKMKKFLGFGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFQ9</accession>
    <name>F9XFQ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_18390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851166.1">
        <property type="nucleotide sequence ID" value="XM_003851118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFQ9"/>
    <dbReference type="FunCoup" id="F9XFQ9">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFQ9"/>
    <dbReference type="GeneID" id="13397906"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18390"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_3_1_1"/>
    <dbReference type="InParanoid" id="F9XFQ9"/>
    <dbReference type="OMA" id="FALWMCQ"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060904">
        <property type="term" value="P:regulation of protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="124" mass="13918" checksum="850208BA2AA3C9FF" modified="2011-10-19" version="1" fragment="single">AIAPKLGNETIKAELGRASWKLFHTMMAQFPDTPKPDESKALKDYIYLFQRLYPCGECANHFGEILKKFPPQTSSRSAAAVWACHVHNEVNKSLKKEEFDCANIGDFYDCGCADDKKDGKDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGD7</accession>
    <name>F9XGD7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_73624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850565.1">
        <property type="nucleotide sequence ID" value="XM_003850517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGD7"/>
    <dbReference type="FunCoup" id="F9XGD7">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGD7"/>
    <dbReference type="GeneID" id="13401138"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73624"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.26"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="InParanoid" id="F9XGD7"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="219" mass="23875" checksum="8176262AEC0F2C1D" modified="2011-10-19" version="1">MAPPTRITVLISGSGTNLQALIDASKTSSLSNTTFVRVISDRKSAYGLIRASNANIPTSYHSILPYKKSHPDTSSNPTFNAAREAYDADLAKLVLADEPQLVVCAGFMRILTPSFLNPLAMANVPIINLHPSLHGDLIGAGCIERAWEEFQQGRRKKTGIMIHYVIAEVDMGEPILQKEVDIEGCTSLVDLQARIHEAEHVLIVDGASTVVEKIRTTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGR4</accession>
    <name>F9XGR4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_94686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851014.1">
        <property type="nucleotide sequence ID" value="XM_003850966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGR4"/>
    <dbReference type="GeneID" id="13397754"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94686"/>
    <dbReference type="eggNOG" id="ENOG502RP8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335619_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGR4"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="850" mass="95452" checksum="8216EF64584C7BB0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHI0</accession>
    <name>F9XHI0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850417.1">
        <property type="nucleotide sequence ID" value="XM_003850369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHI0"/>
    <dbReference type="GeneID" id="13402804"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95115"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.312"/>
    <dbReference type="eggNOG" id="ENOG502R9JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710202_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHI0"/>
    <dbReference type="OrthoDB" id="3646367at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="389" mass="43141" checksum="381EAD768A2C92A9" modified="2011-10-19" version="1">MAPAMRRMAFFDERLPARSTATSTRTVMKGPPHHQTRTSKPTAGSPKQPEPRAAAHRREREHGYRSEPILKDNLATVSSVMSMRTKIIEATFTTTPISKQTASPQPESRISPDLLPDIPTWLACTVAIFFLLGIIMSMLLYCVNFPPKVAWSRERSRNKRHEYQVIDPRNLWVNETNRDSIHDSSPAGSGYQPKNVPSSNSSTPQELHYRRNKRGLAVETRATGIGLGLEVPTIRTSSPSYRKVAPDDDAKDELYDPAATSWRPLPASLHSDQSLLNSTWTNAEDDRSDAPEHDLETGLPNKNRGPWLTPKPSPSGSASSRSSSSSQVRILAMLGNGVERAADYFARVLDDQVQNGDAEGGLLLSVKDCEREQWPPLEMAHVGNAKKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHY9</accession>
    <name>F9XHY9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_47014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850060.1">
        <property type="nucleotide sequence ID" value="XM_003850012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHY9"/>
    <dbReference type="FunCoup" id="F9XHY9">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHY9"/>
    <dbReference type="GeneID" id="13394857"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47014"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="InParanoid" id="F9XHY9"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
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        <property type="entry name" value="Sybindin"/>
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        <property type="entry name" value="Sybindin"/>
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    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
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    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85036.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="175" mass="19645" checksum="848EDE8401221095" modified="2011-10-19" version="1">MSLYSFYIFDRHTECIYSKRWTSPPTTTPIPTEPNKPSSQGLPPSAAATAKLASKNQDVQKLIFGTIFSLRRMARQLGGPSDQFLSYRTGEYKLHYFETPTQLKLVLLTDTRVGNMRTVLHQIWATLYVEYVVKSPLAPVEHKGGVGVGNELFEGGLESFMVSLSCELLWFGESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIG3</accession>
    <name>F9XIG3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">MYCGRDRAFT_100894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850435.1"/>
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    <dbReference type="FunCoup" id="F9XIG3">
        <property type="interactions" value="797"/>
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    <dbReference type="STRING" id="336722.F9XIG3"/>
    <dbReference type="GeneID" id="13395136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100894"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.148"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIG3"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000472">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:establishment of cell polarity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="747"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="895" mass="98369" checksum="3AE678D99D27708A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIJ7</accession>
    <name>F9XIJ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850108.1">
        <property type="nucleotide sequence ID" value="XM_003850060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIJ7"/>
    <dbReference type="GeneID" id="13394730"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95302"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.532"/>
    <dbReference type="eggNOG" id="ENOG502R95K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1099235_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIJ7"/>
    <dbReference type="OMA" id="HETISCY"/>
    <dbReference type="OrthoDB" id="3849578at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29079" checksum="E0B019567A18EE11" modified="2011-10-19" version="1">MSLLGLPAELRLRIYDFLPELQQDRIETVTPYSSHQTPSICRVSQIFHRETLPIYTANSLFSFPIDDAPETWARQVESWILALGPSAISRVRSIQFSQHWNITQPMRWMRHVGFYLRIERSKSSDISSRTGLDQSAGFNDAWADHFVKPSRVSDWQVTSGTYPMARDARARRLQSVELLAQTTEAYFRTRGAQEHSTGLSPGDVWFLMQAVNIVASHAIPYYDFNESGNDRGREPCETWYNMKSELELLVAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIN5</accession>
    <name>F9XIN5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_45762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850279.1">
        <property type="nucleotide sequence ID" value="XM_003850231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIN5"/>
    <dbReference type="STRING" id="336722.F9XIN5"/>
    <dbReference type="GeneID" id="13394707"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45762"/>
    <dbReference type="eggNOG" id="ENOG502S6H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045947_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIN5"/>
    <dbReference type="OMA" id="KVMHVQD"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43622" checksum="A73D8B96B9651683" modified="2011-10-19" version="1">MIVVRSSQTSADLCQGSLLQKTFAHDSDCNEELRLNHIQVVGTHNSYHREISRSERDIFEKYIPDPENVYYSHSKWTDQLDHQSVRSFEIDLHSDTEGGLYAFPLIWKFSNLTEKTAPFNNSIMKKPGLKVFHITDVDTNAICHTFVQCLEQLKAWSESNPGHLPLTFDIELKSDALACGLGGVCAQEAKQWTLERILNVDAEIRSVLSSDKLIVPDDIRRPGLTLEQSVLQHGWPSLKDSRNKFMFYFDNDPDSPDKIRDTYRSDGSESLQNRTVFTNGVEGDADAAFIKFNHPNVTEIQRLVKKGYFIRTRADEPITTLLEKDTTMRDNAFKSAAHVVSTDFPAYGMSARYDSDYAVQLKGGRVARCNPVSAPDWCEDRMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIQ1</accession>
    <name>F9XIQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_46438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850133.1">
        <property type="nucleotide sequence ID" value="XM_003850085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIQ1"/>
    <dbReference type="FunCoup" id="F9XIQ1">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIQ1"/>
    <dbReference type="GeneID" id="13394701"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46438"/>
    <dbReference type="eggNOG" id="KOG2463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIQ1"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="430" mass="47226" checksum="B8CCCC01253DB0CB" modified="2011-10-19" version="1">MATTKPIHTLILDTGALIKNEPPVSTLLSHTEKLITVPAIITEIKDAATRARVETTLKPFLELRSPNPASVKIVTDFARKTGDLSVLSRPDVLICALAYEVECERNGGDWRLRRVPGQKGLNGSPPKRDENGEIVKEGEMKEGEVAMNGTEVEANERTSAASEPSVQPEEIKDEESSATPAASQEPDSADQIASQLQSASLDQQSLPITTTQPDSTEDSDNDSDGWITPSNLKKKQAEDASLSTKDILEPATMQVATLTSDFAMQNVLLQMNLNLLSPTLTRIRHLKTYILRCHACFTTTRDLSKQFCARCGQPALTRVSCSTSANGEFKLHLKKNMQWNHRGDRYSIPKPVHGSSNGRIRGGGKGGWGHELILAEDQKEYAMKSTEEKRKKERGLMDEDYLPGILTGERRNAGQRVKVGAGRSVNSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIQ3</accession>
    <name>F9XIQ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_95352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850273.1">
        <property type="nucleotide sequence ID" value="XM_003850225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIQ3"/>
    <dbReference type="GeneID" id="13394411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95352"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012687_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIQ3"/>
    <dbReference type="OMA" id="ICMSHEE"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29795" checksum="8F93095BA84A8B0E" modified="2011-10-19" version="1">MLQLLRSNPRFLMVVVAFSLFTGVYASLTSIPAQYWITILLISESLTTLLTSPLAGYLTDLHPRREVPFLLSLALMVLAILLFSPSLFIAGRCIQGAATSVVMISGFAMVLDAIPEDEVAVTLGWLSMASTAGFALRPALGGVLYRFGGWWAMFGTLLGLLGVDFGLRCVVVEHRRMPGVDEPGEAVVGNDKLEFKAGSEFRVITEKTDVDAEGQSRGSVPNDGEAFAMLVLLHQPRMLFMLLGVVTLGILLSAFDAILPIFVRDHFTWSALGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ54</accession>
    <name>F9XJ54_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849312.1">
        <property type="nucleotide sequence ID" value="XM_003849264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ54"/>
    <dbReference type="GeneID" id="13398933"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105666"/>
    <dbReference type="HOGENOM" id="CLU_1519062_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ54"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19373" checksum="92A2A5E4F1E03D54" modified="2011-10-19" version="1">MTTLLDLPEETIANILSLVSEDGPVPMVGSGDYPPHSASYSAYFNAALTCKDLHRIVQPELYKFVAFDGNPYRVGRDGSQGGHVDMHSFLRTLFEAPHLRRSIHEIHIKHCSSLMKSQSRTSRVWPDRSPPIWEAETVLGEALASLFEEGGSDEDGAEAENEGGVSLLGLEEVYGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJB2</accession>
    <name>F9XJB2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_87549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849446.1">
        <property type="nucleotide sequence ID" value="XM_003849398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJB2"/>
    <dbReference type="FunCoup" id="F9XJB2">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJB2"/>
    <dbReference type="GeneID" id="13402241"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87549"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="InParanoid" id="F9XJB2"/>
    <dbReference type="OMA" id="NNPMGTL"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="20187" checksum="4F7337FCB7D1932B" modified="2011-10-19" version="1">MAMDTTQDAPAPNSAPETNGLPAIPTVLEPRIPQKKDTSLREFLGKMDDYAPLIPDAVTDYYLTLAGLPPPPETDRRLARLLALATQKFIADIAADAYQYSRIRSTNTTSNNPLTGLGGAAGFGMNMPQGGEGADGAGKGGKKDVGKAAPLGGPRAGYGGGGAGAGQGRTVLTMEDLGMAVGEYGVNVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJC8</accession>
    <name>F9XJC8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_101265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849454.1">
        <property type="nucleotide sequence ID" value="XM_003849406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJC8"/>
    <dbReference type="GeneID" id="13402448"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101265"/>
    <dbReference type="eggNOG" id="ENOG502S14Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_2_0_1"/>
    <dbReference type="InParanoid" id="F9XJC8"/>
    <dbReference type="OMA" id="RYKIEPP"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="509"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="798" mass="90689" checksum="59CEECA474F20316" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJI9</accession>
    <name>F9XJI9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MgAMN5</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_47168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849762.1">
        <property type="nucleotide sequence ID" value="XM_003849714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJI9"/>
    <dbReference type="GeneID" id="13399052"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47168"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="InParanoid" id="F9XJI9"/>
    <dbReference type="OMA" id="YCANGYR"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395649" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="559" mass="62615" checksum="BCD43704F394A6DE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKD1</accession>
    <name>F9XKD1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYP-11</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_47266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849583.1">
        <property type="nucleotide sequence ID" value="XM_003849535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKD1"/>
    <dbReference type="GeneID" id="13402380"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47266"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="InParanoid" id="F9XKD1"/>
    <dbReference type="OMA" id="SETHIRH"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="512" mass="58009" checksum="9FD0B587658A11B1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKH3</accession>
    <name>F9XKH3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849547.1">
        <property type="nucleotide sequence ID" value="XM_003849499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKH3"/>
    <dbReference type="STRING" id="336722.F9XKH3"/>
    <dbReference type="GeneID" id="13402357"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95982"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.614"/>
    <dbReference type="HOGENOM" id="CLU_521958_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKH3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="522" mass="58966" checksum="B8E558E764B0BB41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX8</accession>
    <name>F9XKX8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division control protein 3/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_62823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849231.1">
        <property type="nucleotide sequence ID" value="XM_003849183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX8"/>
    <dbReference type="FunCoup" id="F9XKX8">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKX8"/>
    <dbReference type="GeneID" id="13396590"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62823"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.45"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="F9XKX8"/>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="91"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="469" mass="53304" checksum="BF98ED5A9D16E7BA" modified="2011-10-19" version="1">MASPNGATSPPNRASPIPQSIPNGKPASPLVASSNAMTNGGEKAPQTVSSKDPKAAAQAASDMRNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERKQPSLDFAPKTVSIQSISADIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRFDAYLDAENKVNRMNIVDNRVHACVYFVQPTGHSLKPLDVEVMRRLHTKVNLIPVIAKADTLTDEEIASFKQRILADIHHHNIHIFEGPRYELDDEETIAENNEIMSKVPFAVVGANTEVQTPEGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNFLYENYRSDKLASMGVAQDPSVFKEVNPAVKQEEERSLHEQKLAKMELEMKMVFQQKVQEKESKLKQSEEELYARHREMKEQLDRQRQELEEKKVRIESGRPIEEKGRKKGGFSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL01</accession>
    <name>F9XL01_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_96052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848769.1">
        <property type="nucleotide sequence ID" value="XM_003848721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL01"/>
    <dbReference type="STRING" id="336722.F9XL01"/>
    <dbReference type="GeneID" id="13396603"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96052"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.69"/>
    <dbReference type="eggNOG" id="ENOG502SDK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304435_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL01"/>
    <dbReference type="OMA" id="MAWNKRE"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21552">
        <property type="entry name" value="VEFS-box_ctSUZ12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
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        <property type="entry name" value="VEFS-Box"/>
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    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="816"/>
            <end position="865"/>
        </location>
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        </location>
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        </location>
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            <end position="649"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83745.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="865" mass="98544" checksum="F98C0DBE16D20A0A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLG8</accession>
    <name>F9XLG8_ZYMTI</name>
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            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the HEATR5 family.</text>
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    <dbReference type="InParanoid" id="F9XLG8"/>
    <dbReference type="OMA" id="YPQVIQE"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
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    </dbReference>
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        <property type="project" value="GOC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular protein localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
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        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1865"/>
            <end position="2017"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83890.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLL0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848772.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13397990"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96142"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.180"/>
    <dbReference type="HOGENOM" id="CLU_912791_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLL0"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="305" mass="33980" checksum="182CCF1BCBAB478B" modified="2011-10-19" version="1">MARLRLRLAMEGEIESTNAGRRSYEEEWQRATKGRSTSKTSTQHTYPHIHTPTRAAAQQEQHTTTIPTRTTRAATRTTTHDAGEQTVVHIDCCILNALQPRQTGGRQASRSTTTIQAVNKLHPMPCPMRMQIRRWPPRALHTTTSAHRKIASPPTAQGSAIDCAHKQPTVNASAAFNRRQCEYCQPCPNERPSNSLKHKARQHFTKAEQLQPPAMAERPSEVHHSTSSSNTINASINTHPRATASKQSSQHATPSASDGGPPKQQVILALEQQKRRIDLRKQQPALPDPENYLRRPDSIPKTQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLQ4</accession>
    <name>F9XLQ4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLQ4"/>
    <dbReference type="GeneID" id="13398174"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96317"/>
    <dbReference type="HOGENOM" id="CLU_850492_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLQ4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="37353" checksum="05C448ABCF74E035" modified="2011-10-19" version="1">MEKKLRNAAVADNLPLGVFPDNANGRFIGPCGQRPNQQQARGPPQAQNHQIQQQPRGPPQRDHNQNQQRPRGPPRPQDNQRQQGPLSSVNALRSQHHPPQYNHQLQGPPRLVHPYGRQNNQQRQGPPSFANPYPSQYQPPSARLPYGSYAPQPSFDPRYNLYGAEPQSAFTDRSWQQELARQDRERREAHERAERAADADRLALLFTAGVRPLPGPAVPSELHGYQSTLLDQRDRLLAGRNTTQLTNTQNDTAQQQPVKNVNNKRQREEDEDDEIQPTSPREPSVSRGRRSRRSDPNENQKRIDKSTFFQNGRPTSNCHPRPMREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM77"/>
    <dbReference type="GeneID" id="13396451"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82703"/>
    <dbReference type="HOGENOM" id="CLU_2442556_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM77"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="90" mass="9879" checksum="ABDFB790CEF3FFB2" modified="2011-10-19" version="1">MVKITGYDSNSSVIFRIKAVHRLHFAVGVGEAIEQNPIVYEITLYDRAVGSRDGILVMAVVGRFSWESAARVGQDREAEELESVSAEHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMH1</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMH1"/>
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    <dbReference type="eggNOG" id="ENOG502T807">
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    <dbReference type="OMA" id="YRERAWE"/>
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    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="18192" checksum="D777CC22D7A6DF8E" modified="2011-10-19" version="1">MSDQVQSDWQKEIDRTYHTKHDNGFEPYSAFTMNPNEYGDFSELRWWELGLYGPALLVPKEYAADFHLDPSIHLFYTPGQKGVPSDIKYEGFPVNIQMNHQLHCVNFLRQGLYFNHQYYRDSHHMTWNTTNEKALQIHLNHCVDSLRQNWADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMH5</accession>
    <name>F9XMH5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111164</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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            <begin position="499"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
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        <source>
            <dbReference type="EMBL" id="EGP83249.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    <sequence length="727" mass="75431" checksum="0C92A980F7AEFA14" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMY4</accession>
    <name>F9XMY4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GPM2</name>
        <name evidence="18" type="ORF">MYCGRDRAFT_76815</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">CBS 115943 / IPO323</strain>
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    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
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        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
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        </reaction>
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    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
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        <property type="reaction ID" value="UER00186"/>
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    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
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            <position position="72"/>
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        <location>
            <position position="14"/>
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            <name>Mn(2+)</name>
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        <location>
            <position position="133"/>
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        <ligand>
            <name>substrate</name>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EGP83320.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN78</accession>
    <name>F9XN78_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848389.1">
        <property type="nucleotide sequence ID" value="XM_003848341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN78"/>
    <dbReference type="GeneID" id="13396160"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106144"/>
    <dbReference type="eggNOG" id="ENOG502S6V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068499_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN78"/>
    <dbReference type="OMA" id="VKLWEDI"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20656" checksum="1F3436AFDEFA126D" modified="2011-10-19" version="1">MGDFLANLWGSVFTPGTTPTLLIATNVTFASLQLLLGGLLIATYSIHFAVLSFLCGGLWYSINWFARELQQANIAEQEADRLRKRKKAENEWRATGEVEDSADDEGEDTEVETAGLKDSMENISPEKVPAWAEQQIAEARANKGLQAETSGAQASTGASDARLRRGDQGNVSSSELSTDSEWEKVDNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP04</accession>
    <name>F9XP04_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_10942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847987.1">
        <property type="nucleotide sequence ID" value="XM_003847939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP04"/>
    <dbReference type="STRING" id="336722.F9XP04"/>
    <dbReference type="GeneID" id="13402078"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10942"/>
    <dbReference type="eggNOG" id="ENOG502R1HB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004096_2_0_1"/>
    <dbReference type="InParanoid" id="F9XP04"/>
    <dbReference type="OMA" id="HIMSNID"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391611" description="Mediator of RNA polymerase II transcription subunit 5" evidence="10">
        <location>
            <begin position="19"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="646" mass="71301" checksum="E310FF7C56041C12" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP44</accession>
    <name>F9XP44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_50184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848034.1"/>
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</entry>
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                <person name="Nap J.P.H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
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                <person name="Hane J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
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                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847714.1">
        <property type="nucleotide sequence ID" value="XM_003847666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQA5"/>
    <dbReference type="GeneID" id="13401035"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88478"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="InParanoid" id="F9XQA5"/>
    <dbReference type="OMA" id="DQFSFDG"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="44"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="426" mass="48694" checksum="FA303B1682E61D6C" modified="2011-10-19" version="1">MSFNASAPRERTYDREVDVEDFEEYSPGGYHPVVIGDTFHDGRYHVVHKLGYGGYSTIWLARDQLRNRSVSLKILLASGSENDSEGEILRYLSDGDSWDQGKRFIPLLLEEFSIKGPNGRHSCLVQEPAGCSIPELKENSTNFMFPAETARSIAAQLIMGLSYIHAHGVCHADLHLRNLLLRGPDLETLEPDMLYKQYRLDTVPIRRIDGAPAQPHAPLYAVYPLNNEIPADQIVDPEVQIIDYGTSFMWPADSTPELHSPALYLPPEDFFGEPITPAADVWTLGVSLYEVLGERPLFESFASDRDDLLADTINALGQPPKRWWDKWAQRQEFFQPDGSYIEDIKRIHTPKFRPLQQRLWRLGRGETRETCDWDVEGGEMRALEELLRSMLKFEPSERATAEELLASEYMVKWAMPAWQRQLQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQG2</accession>
    <name>F9XQG2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_30783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847661.1">
        <property type="nucleotide sequence ID" value="XM_003847613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQG2"/>
    <dbReference type="GeneID" id="13401151"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30783"/>
    <dbReference type="eggNOG" id="ENOG502SQ28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_0_3_1"/>
    <dbReference type="InParanoid" id="F9XQG2"/>
    <dbReference type="OMA" id="HLIVCEL"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17816" checksum="7BE228FC69AB74D0" modified="2011-10-19" version="1" fragment="single">RYITTHDFTGKSIYADSPAQVYNYNPGFGGMARSYSVGSVPAGLTDDIDVKAYRAEDAVTSYKRRDIVLPQPGSNLVVVDLEPGASSQMHQTVSVDYSICVIGEIDHELDSGEVVRLYPGDHIIQRGTMHRWTNASKDKPARFVACSLPCEPFDVGSKMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQH1</accession>
    <name>F9XQH1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_88505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847684.1">
        <property type="nucleotide sequence ID" value="XM_003847636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQH1"/>
    <dbReference type="GeneID" id="13401316"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88505"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="F9XQH1"/>
    <dbReference type="OMA" id="HTFPTAW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="350" mass="38004" checksum="9750752955C3BF3B" modified="2011-10-19" version="1">MCDFSQYGGASEEFSELLKTLPDPGEQSVEDLKATVNLGREEVSSEEMKTLAPKVLMKDHSLTTADGETLPLRSYRSSSLPEDEKLPIYIHFHGGGFLFGTLDSEDAACARIAIDVNVVVLNVNYRHTPDWVFPAAWLDAEEAFEWAYTNASDFGGDALQIVIGGISAGGHLSAALAQTLQRDGKPSYSSLKGQVLMIPCVVHEQLAGPLLAQMKDSTVSSYKENEFAPILPLSRMRLFNGLAYPKLPDASDRRANPGLATGQEVEGLPPATVGICGLDPLRDEAFLYASLLAENGVPTNVHLFKGVPHGFRRFGDKLSASAHWDQVMHDGIRWALSGPQAEKEVVVNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQH7</accession>
    <name>F9XQH7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_97524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847680.1">
        <property type="nucleotide sequence ID" value="XM_003847632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQH7"/>
    <dbReference type="GeneID" id="13401318"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97524"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="F9XQH7"/>
    <dbReference type="OMA" id="PYFFLRN"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46041" checksum="AC8E7C7834833A47" modified="2011-10-19" version="1">MGQGSGQSSIRAGSMDKDTTIEHVKSTDGETLEQNILNRYDLLKTKSQEELDALNKKVVKKLDWKFLLCITIMLLMKLYSSDSSEPSLTFQPSSDVSNARLAGMQEDCNMTDVQWSTGISLFYVGYIISQIPANVIIAKGKPQILLPCCMLMWSAVTICMTAMKSPWAFMLCRFLVGFTEGPFLPAVSLMTTKHESPLRREPHQGNIVSNIFSGLLAAGSLTNMDGIANMHAWQWFILLEGIVSIAVACLGFWLIRNWPDNTGTYFFTPEESQMASYRACVSAGGIFEDDEGGMWEDVALACKDPFTWMFASMHFALIIAQSFEDFLPSIMDTFGFSKVNTYLIQAPPILFCMAGAVLITSTLNVAARYFAMFLLCTGPFVGLNLQISWETTVVPRPRTKRAALIAIANCVSSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM7</accession>
    <name>F9XQM7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847485.1">
        <property type="nucleotide sequence ID" value="XM_003847437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQM7"/>
    <dbReference type="GeneID" id="13400596"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97568"/>
    <dbReference type="HOGENOM" id="CLU_1778931_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQM7"/>
    <dbReference type="OrthoDB" id="10632239at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="146" mass="16370" checksum="E8CAFC3578933ACE" modified="2011-10-19" version="1">MSLGNHPTLDLTLDEWDLSCFELEQPQIAGGSDPSQNVDRWPTAVACACPAYSQLVHVQQQFAHRVCNVEVDQQTLKEWASKASVRINDLQLKRNGMSPLQAHFGSLIGGVTRNNKTTVDSEQRQALMDVIIAFETHHPRFLPYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM8</accession>
    <name>F9XQM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_17480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847411.1">
        <property type="nucleotide sequence ID" value="XM_003847363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQM8"/>
    <dbReference type="GeneID" id="13400550"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17480"/>
    <dbReference type="eggNOG" id="ENOG502QTS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058267_1_0_1"/>
    <dbReference type="InParanoid" id="F9XQM8"/>
    <dbReference type="OMA" id="KLTTPCP"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23180" checksum="75D22F53DDFAD3ED" modified="2011-10-19" version="1" fragment="single">NSVTTTSSAQSPAVSASLPKVVYEGSYSAYYGDGSAAQGWPNIDGWIDFEKMFEINHEAMQSSCANWGVPNNSEEEMTDLKAAIVTIGQRSSIDPRFILAIIMQESTGCVRVVSTMGVHPNPGLMQSHQGYGVQVPCPYSSIFQMVSDGSEGTPAGDGLAQVLQEQGHADVSKYYRAARIYNSGRIMPSGLLEQTYQNCCTPAYASDIANRLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQT5</accession>
    <name>F9XQT5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_106596</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847453.1">
        <property type="nucleotide sequence ID" value="XM_003847405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQT5"/>
    <dbReference type="STRING" id="336722.F9XQT5"/>
    <dbReference type="GeneID" id="13400574"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106596"/>
    <dbReference type="HOGENOM" id="CLU_2549379_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQT5"/>
    <dbReference type="OrthoDB" id="3644485at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="83" mass="9473" checksum="D502C46BE44653B5" modified="2011-10-19" version="1" fragment="single">MNAILAFSDVWEHMRQCPMEYTHHRHFLDVSPDQRSLGAALNEPAADSTDDTELDAGSDHHPLDRLVWTGKFVFNLSRPPEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR95</accession>
    <name>F9XR95_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847243.1">
        <property type="nucleotide sequence ID" value="XM_003847195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR95"/>
    <dbReference type="GeneID" id="13399928"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111757"/>
    <dbReference type="HOGENOM" id="CLU_1074454_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR95"/>
    <dbReference type="OrthoDB" id="10423106at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="259" mass="30132" checksum="AFE06A3DFE5ADBA5" modified="2011-10-19" version="1">MHQDHCNHQVHASEQQNAAQQTPENYTTKGFCKEQKVKEKEWPRRLGVLCSVTKALLQREKGIAKLKEENPRLEHDNHRLKNDNQRLEDENRRLWKLVEVIRDDEIDINFPTLFEEFAYGEALHELEELEEAQLNLRRRHVVKHRRKTATGHACRVHMIAQTKQQAESYDYLVGPPAPILVLPAHHLPAHDFAQQPAYRALRTVSCRDPMFEVHAAIFLESSIAGSEFVDLHPDLYEPVLTRSNRLKATEARTDGRHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRD1</accession>
    <name>F9XRD1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847214.1">
        <property type="nucleotide sequence ID" value="XM_003847166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRD1"/>
    <dbReference type="STRING" id="336722.F9XRD1"/>
    <dbReference type="GeneID" id="13399644"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97783"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.9"/>
    <dbReference type="eggNOG" id="ENOG502R0VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645925_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRD1"/>
    <dbReference type="OrthoDB" id="10667035at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="42232" checksum="686D3FE4F5A6207C" modified="2011-10-19" version="1">MPRLQGTLTKVGAALSAAAASNDQVRMYENMSYDDALSGKQVSFSAAWIRNALAFCAKRQISAHCLPQDPKELTEFMHAVGWDVTDEELFTVLATKLLSWLSRTITNKNLSPAMIETKKNPDQTRMADWENVWAAYTLRWIDPSFDFILRQSSPKPPAGMKNLPPRPSVQRQYKSAGALIAATANGLGSLAAPKAGLLKKSEPVLEASAEEESFVVQDLQDLEAESVQNEPDLPVAFSDLSHPQKSAVVPATKIHKPAKNSLPSKAPIPVEIFAAVTADPLFLDWQYEPSSVTLGPLQESSFNYALSHPDFMSWWQADVKAKMKATFEKGQKNIKHRGYTTPPAKTVKTAKKTSTKRAVPVFKKKVQFRSASASSASSSSAGSMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRF7</accession>
    <name>F9XRF7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP82174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRF7"/>
    <dbReference type="GeneID" id="13399702"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97808"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.35"/>
    <dbReference type="HOGENOM" id="CLU_1797971_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRF7"/>
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        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="144" mass="15706" checksum="9506970B7184DF54" modified="2011-10-19" version="1">MSILLPLYLSDCESTRVPTCMESPTPAVPRDRSTPGLKVLDNLQHLPLPGTASEPDIIITIITIIIIVIIVSRISSIAHVHRHINLTLFSPLSICDWFGSSLAPCWVYTHRGLSIPPPPPLVPPLPSLVIVHPSFLFLILAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRQ0</accession>
    <name>F9XRQ0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847115.1">
        <property type="nucleotide sequence ID" value="XM_003847067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRQ0"/>
    <dbReference type="GeneID" id="13399469"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97896"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_18.69"/>
    <dbReference type="HOGENOM" id="CLU_702503_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRQ0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="393" mass="43976" checksum="34CE2CAE317B20FC" modified="2011-10-19" version="1">MAENNEADRCSASCEVGEDFLSDSHGEEALFFDSHDEETLLFDPHREEALLFDPHGREALFHACHVGDSDFDDPVFEAAERRRLQDSWATQEEAQDDVEQDLIRLKSGVKNGTELVGLSAFPRTGIRIRIPHILFALGAIVLLCSGVALVFIDRKRLLVESSALEPCQLSPLPIAPQVPPVDLIRITSNVSTSPMARIRGFDSIWAGVERATQQCETSVAGFNRSIAASTERWNCALHEAAAADALARSQERVFDRLLRDLAWAGMSWLRPRWAGGRATMALEGATAEFHRLYPHRMREVEWQFDELAQVLDVLAEVVRALQQGGLEFAGRAALEEEDERLVGELEQVLRRVVASLEHAVKQARRDGEKWRDAAEMVGERNTAVLEEDRCGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855976.1">
        <property type="nucleotide sequence ID" value="XM_003855928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW57"/>
    <dbReference type="GeneID" id="13403242"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29456"/>
    <dbReference type="HOGENOM" id="CLU_2929238_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW57"/>
    <dbReference type="OrthoDB" id="3641925at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="61" mass="6684" checksum="7AF88A97D2D31025" modified="2011-10-19" version="1" fragment="single">ASTTPFQSQCLSCSQIAAGLQTCARCKAAKYCSRECQAAHWTAHKSACKRLNYVFKVSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWA6</accession>
    <name>F9WWA6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_106990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="GeneID" id="13394335"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106990"/>
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            <begin position="120"/>
            <end position="329"/>
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            <end position="20"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="369" mass="39884" checksum="20921D78BD1CDBA0" modified="2011-10-19" version="1">MAHPIKPPGRLGDPNMSLATDPRTNINLAKALKPLRMDINVPENRITPATASMAQIKKMMAKVNAMEEQTADLMPRDLPGDKTRPEVDCKTVTIKGVDGNDVNLYVYRRADSGNAKLPCVVYIHGGGMVHGQTLSAGLCIAIDFRNAFLPSSDGGIHHPFPAGLNDCASGVQHIASHKSELGISSLVLQGESGGANLAIATTLKAKRDGWMKAIDGVYACVPYISGIWHRPQDQLLKELPSLIENNGYFLQVTSMALMAKFYTPDDKDLTNPLAWPYHATVDELKGLPPFVLVMDELDPLRDEGIAFGRKLVQAGVGVTSSVNLGVIHATSLIFRQALPELHFGTISNIVAFAQSCREDSDTPIRAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWV8</accession>
    <name>F9WWV8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Linoleate diol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_67035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67035"/>
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    <dbReference type="HOGENOM" id="CLU_002329_1_0_1"/>
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    <dbReference type="OMA" id="KIQWDGD"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="125227" checksum="70F5547F6E67B15F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX29</accession>
    <name>F9WX29_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_98830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856697.1">
        <property type="nucleotide sequence ID" value="XM_003856649.1"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="177"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="577" mass="64131" checksum="80240C99F6DE8923" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="15335" checksum="048E3339CDB60BA4" modified="2011-10-19" version="1">MAPVPLTIIKGAGQQHIPIPEGESAIVADFHSIQTQTQEGVGPTYLTSGFYRIQPGPTRNIPTYTYEETKYVLNGQIDVLDEATGVTHHLVAGDWAFFPVGSKAQFSSKSGGTAFFAVTRPVINTHPGLVGRAEKVPGTQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXV4</accession>
    <name>F9WXV4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_78335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856118.1">
        <property type="nucleotide sequence ID" value="XM_003856070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXV4"/>
    <dbReference type="GeneID" id="13403101"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78335"/>
    <dbReference type="HOGENOM" id="CLU_2529189_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXV4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="84" mass="9353" checksum="98802F205F3046F8" modified="2011-10-19" version="1">MSALLLDCQCGPLPERSIVLVACLDPDDRRVESFFVTSCLSDCLSIHARLFGFRKLSEMICAADKSGEYSSASLERIKVRLRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY10</accession>
    <name>F9WY10_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenylacetaldoxime dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_66002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856258.1">
        <property type="nucleotide sequence ID" value="XM_003856210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY10"/>
    <dbReference type="GeneID" id="13402969"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66002"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.909"/>
    <dbReference type="eggNOG" id="ENOG502SHKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065607_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY10"/>
    <dbReference type="OMA" id="DNMCHIR"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40654" checksum="EE112DC625C1949D" modified="2011-10-19" version="1">MGSFDRDERTYPLKRPRGHKPPVQRWSLKFPAAVTYIYTLYVGIQSRGNGSAAQSKAESIVQALLDESKAPAIDTFRVTNGFDVKGSRVWVAYWTNEEDFKSALKLLDLARIWESLGDDKHDVGIWREDFAAPKERLETNYARLDHKPGLARLPDTEQPSHDLTAYWGAGRDRIPASAHDRFETPKEIPLPSNVPKGFGQRLTGSNYENMCHIRSGQWWELCEEAERESYENDLEPKLMGGMNYLWEHPEETGTIGLRFLQNLNDNGEPIKETCGAGFHKNWADLEKWSSRHPSHLAIFNGMVAHAKKFGDGRKLMTWHEVWIFKEGEARFDYVNCDPTTGVIRFVELEQQPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY31</accession>
    <name>F9WY31_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857287.1">
        <property type="nucleotide sequence ID" value="XM_003857239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY31"/>
    <dbReference type="FunCoup" id="F9WY31">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY31"/>
    <dbReference type="GeneID" id="13394941"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107316"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1153"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY31"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="317" mass="34228" checksum="3F766284DFCB68AC" modified="2011-10-19" version="1">MASKTAVRYLAKSLTRPTVAAGSTTRCARLAAASIPAIRTFSDSPRTSPLSASSRRQRPSLRSGGQTSATSPAPNAQARRTIFIQTEDTPNADALKFIPNHTVIPDGFPSTFLEYLSPRSTLAPPHPSPLAAQLMNVDGVTSVFYGKDYITVTKDSTTPWPHVKPEVFALITEAVTTGQPIVNTVENKTGEEGQGSSNSEVTATYDPEDEEVVGMIQELLDTRIRPAIQEDGGDIEFRGFHDGQVMLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVKGVQQVLDQEEEVALQEFAKFEEKLKAAKGDAPETSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYB8</accession>
    <name>F9WYB8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_84039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856540.1">
        <property type="nucleotide sequence ID" value="XM_003856492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYB8"/>
    <dbReference type="FunCoup" id="F9WYB8">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYB8"/>
    <dbReference type="GeneID" id="13395249"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84039"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="InParanoid" id="F9WYB8"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18872" checksum="A0BFC29BCD03C688" modified="2011-10-19" version="1">MAVDLATLSTQQLSQVKKQLDDEVQHLTNSYQNLRTAQQKFRDCIASIKTGVANSVKGAASPTRTPRRTVSCTNLQPDKPLLVPLTSSLYVPGKLADPENVLVDVGTGFYVEKSTKDAQKFYEGKIEELGKNIKDLESIVNGKANNLRVVEEVLRQKVLLGQQQGGQSEASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYT5</accession>
    <name>F9WYT5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_34938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855929.1">
        <property type="nucleotide sequence ID" value="XM_003855881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYT5"/>
    <dbReference type="STRING" id="336722.F9WYT5"/>
    <dbReference type="GeneID" id="13403283"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34938"/>
    <dbReference type="eggNOG" id="ENOG502S73M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_6_1_1"/>
    <dbReference type="InParanoid" id="F9WYT5"/>
    <dbReference type="OMA" id="IECNDEV"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="97" mass="10489" checksum="E8C729DD7E56B8CA" modified="2011-10-19" version="1">MTATKPPAGHFTLLYFAASTSYSRKEHDFFQAPLPIAKLFDMLDNQYPGIKSRVLDSSAVTVNLDYVDVEEETGKGDAGLIIKEGDEVAIIPPVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZK5</accession>
    <name>F9WZK5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF336-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_28809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855874.1">
        <property type="nucleotide sequence ID" value="XM_003855826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZK5"/>
    <dbReference type="GeneID" id="13403796"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28809"/>
    <dbReference type="eggNOG" id="ENOG502SUKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_1_1"/>
    <dbReference type="InParanoid" id="F9WZK5"/>
    <dbReference type="OMA" id="QDEHCAQ"/>
    <dbReference type="OrthoDB" id="5075159at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="16788" checksum="A5118DEC56253E0F" modified="2011-10-19" version="1" fragment="single">LAYLLALASAQVNRTLTNGWGSTPSDRHYINETQAQAVITAAIAKSYEIGVPNNIAVADPSSQLVAFLRMDNAFLASADISIKKAKTVTLFNGLFPSSGIYNRSQPGGDLWSIVETNGGLIAFGGGVPIFDHQGYWIGAVGVSGGSVEQDVMVATAGAEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZP0</accession>
    <name>F9WZP0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_33747</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="274" mass="31036" checksum="42F7EE99EA52E8B8" modified="2011-10-19" version="1">MPPSSKDAGDDKDGTADIAPKANETPVLQQPATNYSKTIVMGKVSSEDTDWVATELPDWDRAIYVVDLPSNATSPTGLRTKLNKAREANPYLTFIIENYDNLPDIAVFLHAHRNGWPAAWHNDANGHDAVVMLKELQLATVEKRGYVNLRCIHDPGCPRELDMNPPGPANQVEDAYPHVYAEMFNMTVDAVREQVPEVGSPCCAQFAVTRAEILKRPKSDYEWILAVLERSELEDYVLGRVMEYTWHILFGRDAVYCEDHRVCWREVYGRPSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZU3</accession>
    <name>F9WZU3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="8">GTP-binding protein Obg/CgtA</fullName>
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    </protein>
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        <name evidence="6" type="ORF">MYCGRDRAFT_22915</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="GeneID" id="13403161"/>
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    <dbReference type="eggNOG" id="KOG1489">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="InParanoid" id="F9WZU3"/>
    <dbReference type="OMA" id="PRVGHWE"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
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        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="249"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55396" checksum="547EE6D600D13379" modified="2011-10-19" version="1" fragment="single">HLDPVPPDYSAQPFTDACSLTVSAGAGGHGCVSFLREMFIPNGPPNGGDGGTGGSVYIQAVKGETSLHKIARRSILKAGRGKNGQGSSRGGARGEDLLLTVPVGTVLREVWRIDPVEVEQDRQASEAADNYTRTTNADEEEGKEPAQNGDFRRDKWIVYPGTLPKSFGIADFPPTPKPRRSHLTALQPPAPLRLDLDTHMETPMLLAAGAMGGLGNPHFVTKTQSRPKFSTKGEDGMKIHLQLELKLLADVGLVGLPNAGKSTLLRAVTRSRTRVGNWAFTTLSPSIGTVVLDTHTGRPALDTKGRRKEPRTQFTIADIPGLIEDAHLDRGLGLGFLRHIERAAVLAFVVDLSARDAVAAIKALWREVGEYEKLREQELNAETQRLNPSEDGVVAFQPLEPSAPSHPSASDLEEQSSGTMLNAPLGRDLPALSLPPISSKPWLVIATKADLPDTRENFAKLQDWLKRIETGEEEHPSGKKNAWRKRMYSMPVSAINKEGVARLPEIVLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0U5</accession>
    <name>F9X0U5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_35100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857472.1">
        <property type="nucleotide sequence ID" value="XM_003857424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0U5"/>
    <dbReference type="STRING" id="336722.F9X0U5"/>
    <dbReference type="GeneID" id="13403043"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35100"/>
    <dbReference type="eggNOG" id="ENOG502S7KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107714_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0U5"/>
    <dbReference type="OMA" id="KMRFYQV"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16494" checksum="592505CF8BF6C89B" modified="2011-10-19" version="1">MSQYSASVPNDGQVKPAIHAFFERFYKISDTPDGHEDYANQFTSDGKLIMGLNEVNGRDGIIKMRHAMWEKVAKRSHKPAQLYSFGSGSDDIMLFGTVDYTLKDGKGTTVDWAARAHFVGDGDDLKMDFYQVYLVGIGREDFVNGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X102</accession>
    <name>F9X102_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_83802</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856324.1">
        <property type="nucleotide sequence ID" value="XM_003856276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X102"/>
    <dbReference type="STRING" id="336722.F9X102"/>
    <dbReference type="GeneID" id="13394805"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83802"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="InParanoid" id="F9X102"/>
    <dbReference type="OMA" id="DIINYNP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389895" description="Crh-like protein" evidence="18">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP91300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="374" mass="39429" checksum="1F0F4FD4949494A2" modified="2011-10-19" version="1">MRFQLFSQRAAVALATSLPLILAQTSTDCDPTKKSCPADIGLPASKYVADFTTAGANSSWTAAAYTTIEYGSDGAVFTIAKEGQAPTIETDFYIFFGRVDVTMKAASGRGIVSSIVLESDDLDEIDWEFIGGDNGKVQSNFYGKANTTTYDRVVYHDVATPQDTYHTYSIDWTSERLQFLIDGSIIRTIAYADPLAVYGKNYPQTPMRVKLGNWAGGGPGQNKGTVEWAGGDVDFSKGPFKMLVRKVEITNNNPACSYEYGDRSGSFESIKKGTAVTDATTVSRSVAPIRQTVLLSTTVTGSAYSTNSASVSALNSDVPTGSAESTTDTTSAVGSDSPAATTSSGVETSTGGASTNTILTAGSFVGVAVGFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X156</accession>
    <name>F9X156_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_107402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
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        <property type="protein sequence ID" value="EGP91435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003856411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X156"/>
    <dbReference type="FunCoup" id="F9X156">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X156"/>
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    <dbReference type="eggNOG" id="KOG2072">
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    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
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    <dbReference type="OrthoDB" id="18884at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="345"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP91435.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123013" checksum="FBA37A649A6EBCD3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1M9</accession>
    <name>F9X1M9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_23624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP91839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="13398388"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23624"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="4"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="435" mass="48342" checksum="600979BADDD245A4" modified="2011-10-19" version="1" fragment="single">DASFDAFVEATMAEFKTPGMAILVVNKDRISAKGYGYSDISQKTPVTPHTLFYAASTTKSFTSAMAAHLVESTDHPTIKWDTPLAELIRDDFVLDQSTPEGRWATDHVTVEDALSHRTGLSGNDMIWNNGVVSNRDIVRALRHVPVKSQLRSRFAYANNPYTAVAHAVSTTLDRPFGDLLKENIFDPLNMEHTIYSLDDARTIVEKSDHVNLARAYIWDDSSQSHKLTDWDNLPPSNGAGGIISNVLDYSRWVRHLMKPSDRTLALSKNAVKAMRTPRIMVPPDETHVGAQAYCLGLFSQVYRGRETLEHGGAIGGFMTEMTMVPPTAEDIKQGRGDAGWAVIVMQNTYSSAAGIVVWHLLDEYLQVPVAERPDRVERAKERQVNAEETLLPENVVKRLFGFTAPATSIQPALDLESYQGIYSHPAHHKLKITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X220</accession>
    <name>F9X220_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855800.1">
        <property type="nucleotide sequence ID" value="XM_003855752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X220"/>
    <dbReference type="GeneID" id="13395890"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90364"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.69"/>
    <dbReference type="eggNOG" id="ENOG502RM6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543163_0_0_1"/>
    <dbReference type="InParanoid" id="F9X220"/>
    <dbReference type="OMA" id="SSELAYY"/>
    <dbReference type="OrthoDB" id="3648100at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="56859" checksum="743D7A6140F67646" modified="2011-10-19" version="1">MSSKDSIARCAHQDSNQHGGHVLHFEYSIALIGDNKPALEPPLHVQHRTRPPADRTTFGLISTRFYAVLSSGVTRLPRFYHVALDNLVDAIMNLRDAPGESTLEFAAFFDEARGERRHRCRLTTWYQQGQASTVYFVIGEDSWKYLMEHAGAHQWINTMQHLEQRASDRAVYHIREELIKCYPDTDIVEAEENSWNVRWATKMRTNVLEVLCSRLHPFQPPFGYPGVGDLHVMLPCGHAQSMWEDTLHNLRVDQCKAVNCPTCKQRTLQPEDEIELAVSTEVLTTQEEYLREHHHWSRIRELSTNDDLHLPGTAIAVALDLSLESFKAPTFVNPNEFSLAEHKPTEEVMDHFSAMFFGSSSVISKSQEDLVDMLMSEALNLPVGERAEKLSESFLPPGYVNFLLLWIGRAVIFLAERRCRRVGSAHAGVHRHGDDLVYNSDLFRQANAVGADSASVQLLTDLDSTAIDFEAVRDALAKLQLPATATVADMMKELEKMQLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X269</accession>
    <name>F9X269_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855693.1">
        <property type="nucleotide sequence ID" value="XM_003855645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X269"/>
    <dbReference type="STRING" id="336722.F9X269"/>
    <dbReference type="GeneID" id="13403633"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107929"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.295"/>
    <dbReference type="eggNOG" id="ENOG502SUBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085820_0_0_1"/>
    <dbReference type="InParanoid" id="F9X269"/>
    <dbReference type="OMA" id="APSHHYH"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="189" mass="20622" checksum="097A1298BCECDB94" modified="2011-10-19" version="1">MTSQRPFFGNFLAAFRAHSQSIPKTSTSLSNGAAASLWTAAPQQRPKSTSPDPEQTSQKTAHPKTNPYNPASTTAAQDRQLVQQLPPLQHNVSPQTHLARPPTSPGLPIYGPENKPRPNYPSAQEVRRSRRRGSDSSSDSGGFREVRGGAGEKWFIGGLTAGGEEKYYKLSMVKRDKSSDRISTDQMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2Z4</accession>
    <name>F9X2Z4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_68390</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855541.1">
        <property type="nucleotide sequence ID" value="XM_003855493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Z4"/>
    <dbReference type="FunCoup" id="F9X2Z4">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2Z4"/>
    <dbReference type="GeneID" id="13403481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68390"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.598"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009667_4_0_1"/>
    <dbReference type="InParanoid" id="F9X2Z4"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
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        </location>
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        </source>
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        </source>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
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        <source>
            <dbReference type="EMBL" id="EGP90517.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="644" mass="71190" checksum="1800A64393256424" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X304</accession>
    <name>F9X304_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <sequence length="727" mass="79684" checksum="9B342D359452DF68" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q5</accession>
    <name>F9X3Q5_ZYMTI</name>
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        <submittedName>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854964.1">
        <property type="nucleotide sequence ID" value="XM_003854916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Q5"/>
    <dbReference type="FunCoup" id="F9X3Q5">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3Q5"/>
    <dbReference type="GeneID" id="13399604"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36271"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="InParanoid" id="F9X3Q5"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="296" mass="34970" checksum="C3B312AD48549683" modified="2011-10-19" version="1">MLPHTKNTYWHEFDQTAGFNVQLNYFERLWAAWYAYIGNDALATGIMSFVMHETFYFGRALPWMIIDQIPYFNKYKIQNQKIPSAKEQWDCAMLVLLSHFTVELPQIWLFHPMAQYFGLATSVPFPPWWKMAYQIAIFFVMEDTWHYWMHRAMHWGPLYKNIHKIHHQYSAPFGLAAEYASPIEVMVLGLGTVGSPILWCAVTKDLHILTMYIWIVCRVFQAIDAHSGYEFPWSLHHILPFWAGAEHHDTHHEKFIGNYSSSFRWWDYVLDTESGPEASKRRREAKLAKLRAAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V0</accession>
    <name>F9X3V0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MYCGRDRAFT_108192</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855064.1">
        <property type="nucleotide sequence ID" value="XM_003855016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V0"/>
    <dbReference type="STRING" id="336722.F9X3V0"/>
    <dbReference type="GeneID" id="13399855"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108192"/>
    <dbReference type="eggNOG" id="ENOG502S1VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047751_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3V0"/>
    <dbReference type="OMA" id="GSSHWGF"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395496" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGP90040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="460" mass="49905" checksum="8556E506BEA84F75" modified="2011-10-19" version="1">MPSISTLLLFPAAISALTFDCSHVRVGGQSFNLEKLGGPKEVHYQERNDLYISNTTFTIDICAPLERDTDSEKAKFECPSGTRVCGVERQYQGDKDPLVDKVIPIAGDFTTSHGSSRALDPKFERLKGSDSSADSDKEGLRGKLHGGEFKNKKQKAIVEFLCDEKLEGTEGFDSKEKRSATDANLYGSMGKREAEDKGDGDDKEKDPLPDLDAGKSLSFVSYKEEEDVGVLRLTWKTKYACEGAADKKPGGKKTAGWGFFTWFLIIVFLLVAAYIIFGSWLNYNRYGARGWDLIPHGDSIRDLPYIVKDVGGNIVDRLKGSGASRGGYSARHLAVATDVSDLGPLSQPTSGPLGDEQCEEDPRDEGHGVQRKYNCSSEIKSNVESTVACIFQVMQRSNGVQTLASCRRVVKAIAVVAMKHPSHVRGPSRSSTSGSGIAVMENLAEPGPASPMAIDTLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3W0</accession>
    <name>F9X3W0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855417.1">
        <property type="nucleotide sequence ID" value="XM_003855369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3W0"/>
    <dbReference type="GeneID" id="13400015"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90976"/>
    <dbReference type="eggNOG" id="ENOG502RKXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345886_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3W0"/>
    <dbReference type="OMA" id="GLAHWPP"/>
    <dbReference type="OrthoDB" id="3650051at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="817" mass="91969" checksum="FE602FF2CB45EB55" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X437</accession>
    <name>F9X437_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_36977</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854777.1">
        <property type="nucleotide sequence ID" value="XM_003854729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X437"/>
    <dbReference type="FunCoup" id="F9X437">
        <property type="interactions" value="1123"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X437"/>
    <dbReference type="GeneID" id="13395962"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36977"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="InParanoid" id="F9X437"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="136"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="339"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="529" mass="57037" checksum="2F1BCFE0D420FBB9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4M4</accession>
    <name>F9X4M4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855096.1">
        <property type="nucleotide sequence ID" value="XM_003855048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4M4"/>
    <dbReference type="STRING" id="336722.F9X4M4"/>
    <dbReference type="GeneID" id="13400939"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91020"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.911"/>
    <dbReference type="eggNOG" id="ENOG502RB4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523758_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4M4"/>
    <dbReference type="OMA" id="IHEWASV"/>
    <dbReference type="OrthoDB" id="3637243at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="642" mass="71880" checksum="2825B16AAA483E56" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4S3</accession>
    <name>F9X4S3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STL major facilitator superfamily sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_35613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855191.1">
        <property type="nucleotide sequence ID" value="XM_003855143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4S3"/>
    <dbReference type="GeneID" id="13400284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35613"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="F9X4S3"/>
    <dbReference type="OMA" id="WTIWVAM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="52393" checksum="4F86DE34E8D88DD8" modified="2011-10-19" version="1" fragment="single">LSSYDQGVLSGLLANPYFEAQFNYPDDVTTGITVASYCLGCLVGCALSFAIGDMLGRRKMIWLAMALIVVGATLQASAYSLAHLIVGRVITGFGTGIDSSTIPMYQSELSKKENRGRLVSWEIFFIGIGIATAYWIDYGFSFVDSEASWRTPVAIQLIFAIVVIFVVWGLPESPRWLAKRGRDAEAEEVLCAVFDTQPNDPFIVEEMRAIRAAVALEKTEGKKGYGSIFQKDILKTRRRVALAWFALFMNQLSGINLVVYYMPTVLLDIGQSRNNSLLIAGGVQLMFPLGNLVPAFFLDRMGRRPTMLWGCGLLSFCMVMITILLSFGTDNFNTSSASIAFFYLYMLIFGGTVNVVPWVYGPEILPLEARTRGTAISVSSHWLWNFFIVMISPVLINRIGFHTYIIFAILLACFIPIVYFFYPETSNISLEDIDKIFLPEHMHDSYTNQQHEVFGGSDSSKGEINQTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4Z5</accession>
    <name>F9X4Z5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SDG2404</name>
        <name evidence="21" type="ORF">MYCGRDRAFT_20674</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
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            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGP90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003855184.1"/>
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        <property type="interactions" value="98"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20674"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008492_0_0_1"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
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        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SRI"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="576"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="681"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="740"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
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            <dbReference type="ARBA" id="ARBA00022603"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="799" mass="89713" checksum="E85679F80ECF020A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5J9</accession>
    <name>F9X5J9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_69516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14822" checksum="E095AD6748DC72DF" modified="2011-10-19" version="1">MASRTLFLRLTRAPTKLSSPSTLLPRIAQPSRRPLQRLSVRTYSASPSTEVQAPDYLNESERQIFDKLKTSLQPSKLEVQDISGGCGSMYGLDIVSEQFKGLSVIKQHRMVNQILGEEIKKWHGVQLKTKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="303"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88830.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="43255" checksum="2271D3697834B818" modified="2011-10-19" version="1" fragment="single">MSCNTTLEDLHIIEEPLWKDFTFHHLGLALGAVFGLLSVIISLCLIAQHALHYSKPTEQRHIIRILFMIPVYSVVSFLSFLFYRKAIYFQVMRDCYEAFAISSFFALLCHYIAPDLHEQKMYFRTVTPQNWFWKAFWLQSCTGGENKGPFRRPRSGLTWFNVIWVGIFQYCFIRVFFTIVSVISEAFGRYCEASLHPAFAHIWTMVFESISVTIAMFMVVQFYIQLKPDLAEHKPGIKVVSIKLVIFFSFWQTIIISFLSSSKGPLQPTKQLAYQDIKIGIPSVLLIIEMALFSVLHVFAYPWKPYSKKHASKDDLTPLDSDRTEPALEYYGGFMGIRAITDAFNPWDIVTSSARGFRWLFVGSRVRHRDTSY</sequence>
</entry>
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    <accession>F9X6P8</accession>
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        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853634.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X6P8"/>
    <dbReference type="GeneID" id="13395778"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79794"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.171"/>
    <dbReference type="eggNOG" id="KOG4177">
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    <dbReference type="InParanoid" id="F9X6P8"/>
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    <dbReference type="OrthoDB" id="3650131at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="104" mass="12408" checksum="57D781CA2B4288C1" modified="2011-10-19" version="1">MWLLHVRTRELVHFMDDRSVIGKYAILSHTWEDEEVSFTNIKTSEAHDMMGYRKIDYTCRQAEADDLEYVWVDTCCINKDSSAELSESINSMYRWYYNAKICYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X761</accession>
    <name>F9X761_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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        </location>
    </feature>
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        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="780" mass="83634" checksum="58190ED465F07E59" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R1</accession>
    <name>F9X7R1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_69748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853801.1">
        <property type="nucleotide sequence ID" value="XM_003853753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R1"/>
    <dbReference type="FunCoup" id="F9X7R1">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7R1"/>
    <dbReference type="GeneID" id="13404140"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69748"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.447"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9X7R1"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
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        <location>
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            <end position="813"/>
        </location>
    </feature>
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            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="859" mass="97841" checksum="D3D94E73FE868C5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7S4</accession>
    <name>F9X7S4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854456.1">
        <property type="nucleotide sequence ID" value="XM_003854408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7S4"/>
    <dbReference type="GeneID" id="13404147"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108584"/>
    <dbReference type="eggNOG" id="ENOG502SC3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9X7S4"/>
    <dbReference type="OMA" id="CRGKPKC"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391185" evidence="3">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="50627" checksum="87573B20EF2D49C3" modified="2011-10-19" version="1">MRRSAGILTLTACAIRASAFLLPPGFTIASGHRLDPAALLGAGLAKSRALTLQCSECAFPPPKAEITEEAEGDVFRIQGGANSVLVNFSIAEDGKSLEFNGNTIYPLDSVVDVFSKAYVKQVPDSATLEEIKTSESKYTPLEVTGSGVVVQQEEMVTPAGDVLIPIKYTIFGLEGQPVSIDEVQIKLLKTTAGDLYIMLVGTLGRLPPRPDDTILPHAGYIDMLFPPPPSHQKTDEDCKVLPPALCKLRNMLEAKISGMKKHGGMRRPCPGMMNMKDGKSRHHHDSKPGRLPPGLFGINPTDAPPSPHGRPHHHRPHHGHHQHSFFENFSRGFAAVLIPTLAGIAVGMMVSLLGLVLGRVIGYLWIKLYRGGRKGYASVALDESSAEAVDGEKAFVEQGVVEGGLPAYDGPPAYDEVAVKADKFLKPESKIVRPACAAKPSQESFHRTMYNRPVADTDPAAKQYGAVNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7S8</accession>
    <name>F9X7S8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7S8"/>
    <dbReference type="GeneID" id="13404150"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108587"/>
    <dbReference type="HOGENOM" id="CLU_649255_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7S8"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391431" description="Prion-inhibition and propagation HeLo domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47251" checksum="26FE87EEDAF49CC1" modified="2011-10-19" version="1">MEVAGVVLGAIPVCLLVLEGWEAVEPRVKTFWHAHIAISRYVCALRGHRDNLEVIIKTMLHGCMPIEKIERDFRTLLTEDWSTPTHIHLASKLRSKHGENYQLFQAGMQGICNDIKAVVIILGLWPSRDEMSNEQLDIIVKQHRSPSSGSSRVQTRFRFTFKHKAIKSAFTSLATDIDSLSNRLKNNQIWQNLKHNERVQDASDQVQRQRHHLKALAHEIERATASARHTRSVEFAILLDSGTVAREHMPQAARGQPCLTGNYIPQPGSGLSTHHNRLNLISARGMLGKTVPRASRLQTAAIFTSWVQLLYGTPFMTTAWAADDIKFNDTDPGTLPLKAPLLCLRTGLDQVSTALHGLRDPTHISTTGLANLLNELMETEAHDLPIAYARAVSDCWRLGHMPSAFDAEFGDLTDRVTRTAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8B5</accession>
    <name>F9X8B5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92420</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853501.1">
        <property type="nucleotide sequence ID" value="XM_003853453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8B5"/>
    <dbReference type="STRING" id="336722.F9X8B5"/>
    <dbReference type="GeneID" id="13397234"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92420"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.257"/>
    <dbReference type="eggNOG" id="ENOG502STHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363779_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8B5"/>
    <dbReference type="OMA" id="HEDIAFM"/>
    <dbReference type="OrthoDB" id="3556832at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="768" mass="83001" checksum="243A301BCF0B85F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8D1</accession>
    <name>F9X8D1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2 8">Superoxide dismutase</fullName>
            <ecNumber evidence="2 8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_104097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.274"/>
    <dbReference type="eggNOG" id="KOG0876">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="10">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28881" checksum="583AAA5B795CD416" modified="2011-10-19" version="1">MQLSNLTTFALAFFSDTGNWMVNSAQTRLQSLQQSFSASSISDNTTTTATMPFTLPQLGYSYDALEPHFDKETMEIHYSKHHQTYVNNLNNLLKDHELATADVNDIVTKLDQVPAEKKTGVRNNAGGHSNHSFFWKNLKLNTTLDGELEEAIKKDFGSVEDFKSQFEKAATTVFGSGWAWLVDQQGTLKIVTTANQDSPLMGEAVSGAKGYPIVALDVWEHAYYLKYQNRRPDYIKAFWSVVNWDFAKQRFAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8E5</accession>
    <name>F9X8E5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_92586</name>
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    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9X8E5"/>
    <dbReference type="GeneID" id="13400220"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92586"/>
    <dbReference type="eggNOG" id="KOG1632">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015434_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8E5"/>
    <dbReference type="OMA" id="TIYKKTC"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="627" mass="67697" checksum="EB1F123DF5FD0947" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8L8</accession>
    <name>F9X8L8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_71564</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="478"/>
            <end position="641"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="648" mass="71108" checksum="259A143FE02156CD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X907</accession>
    <name>F9X907_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_99952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X907"/>
    <dbReference type="STRING" id="336722.F9X907"/>
    <dbReference type="GeneID" id="13400196"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99952"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.510"/>
    <dbReference type="eggNOG" id="KOG2690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035242_0_0_1"/>
    <dbReference type="InParanoid" id="F9X907"/>
    <dbReference type="OMA" id="TYYEGAR"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="432" mass="47341" checksum="335287BC0DA6A67B" modified="2011-10-19" version="1">MDVAYDHIQKDALDPSEQPEGNTETPRANTTSNLNTEFSQAFKAVSSSPWGAKLNGWFSQAVEQSSTFYQDLSKEVSETSTQASKGLSRVAEEVANRTAALKLDSTAPGPEVRVPGEEAVPGVTFVEAEGEGSSQERSENLSADIVKEAGSLVASFRSTAAARLKDLQKAEDAADEALLKFGTNIRSFLRDAVSITAPEDGDGKTALGTDGVGNEVLFETQESGTGKKVFHTTRLDAQLHAIHSSAGSFTDEPQGQEWEEWEKTFDVEARTAEIAKDLEKFEELRRAMERLVPEKVDYKTFWLRYYFLRRAVEEDEKRRREVLKGATADPEEEVAWDDDDDEEDDKSATPNKISSVSHKASASTTTITAPTTTDNATLKPISPRRSDEENRSVADSEASYDLVSGATSRAQGSPKEAKTEGKDESDDDDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9F6</accession>
    <name>F9X9F6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109004</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852892.1">
        <property type="nucleotide sequence ID" value="XM_003852844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9F6"/>
    <dbReference type="STRING" id="336722.F9X9F6"/>
    <dbReference type="GeneID" id="13397213"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109004"/>
    <dbReference type="eggNOG" id="ENOG502RZVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022564_2_0_1"/>
    <dbReference type="InParanoid" id="F9X9F6"/>
    <dbReference type="OMA" id="WTKSRIR"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="514" mass="56076" checksum="F4D2A9F67AF79531" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9G9</accession>
    <name>F9X9G9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853460.1">
        <property type="nucleotide sequence ID" value="XM_003853412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9G9"/>
    <dbReference type="GeneID" id="13397273"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92489"/>
    <dbReference type="HOGENOM" id="CLU_625861_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9G9"/>
    <dbReference type="OMA" id="ATPDCPI"/>
    <dbReference type="OrthoDB" id="10407558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="438" mass="47605" checksum="4B597AD619667964" modified="2011-10-19" version="1">MASVRSRVPMPQAFLPYRAVARVSLFELSDLTITPSRHTIASAASCHTSRTTTATMPERYRIRIEERHRANSLLQQPARRNLSPSLSPSPSLNSSTRAIKSPPSSRTSRLPVRHSSTISRVPILRSGKASLVSIPPGRRAERSVTSSPDGTWGRSSDDEEEVTTPAEIGHPQGFDLHARLPAPRLEDSSTSDSASLESVRRSQRERTLQLLEGGPASPKLPGSVQNARMGIPTRAAGSLPRRAQEIKTRSSPPDISDRATKIRNRRSTGLDMTESAIPADIPRARIPTTTARKPATSRAKPAPARHHTRNPFTKLQSLLKSALPKPRSRIPTPSTPPPRPATTSPPTRQKSRIPPPRPARSPPRTPSPNLPTPQSTRAVPTTTAPAQRDTNMPAALGLISALTRAAHTHTIGPHRARILRFANVRLPTSSPISYLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9M6</accession>
    <name>F9X9M6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_40235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853063.1">
        <property type="nucleotide sequence ID" value="XM_003853015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9M6"/>
    <dbReference type="STRING" id="336722.F9X9M6"/>
    <dbReference type="GeneID" id="13400171"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40235"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_1"/>
    <dbReference type="InParanoid" id="F9X9M6"/>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="71"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="395" mass="42873" checksum="C3152DC7652851B2" modified="2011-10-19" version="1">MIRPLCSNASRIARTTSTSITKRTYASHPPNARLNIPTNYATTPLLHHTSKSALVNQELPQSARDGTTCRQNLFQAVNSALAHALRSDPRVLLFGEDVAFGGVFRCSMNLASEFGDARVFNTPLSEQGLVGFAIGAAAEGMRPIAEVQFADYVYPAFDQIVNEAAKMRYRAGVHAGTQNCGGLVIRMPAGGVGHGALYHTQSPESLFTHIPGLRVVVPRSPTQAKGLLLAAVACPDPVIFMEPKILYRAAVEHVPAEPYELPLSKAEILKKGSDVTIISYGTPLYTCQNAITAAEKDLKCSVEFIDLRTIYPWDRQTVMESVNKTGRCLVVHESMVNAGVGAEVAATIQEGCFLRLEAPVQRVAGWSTHSGLAYEKFNIPDVARVYDAIKNVLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA75</accession>
    <name>F9XA75_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="eggNOG" id="ENOG502QTQR">
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Gfd2/YDR514C-like"/>
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        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.158"/>
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    <dbReference type="InParanoid" id="F9XAV9"/>
    <dbReference type="OMA" id="RVIATYI"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF00615">
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="F9XBF9"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="151" mass="16332" checksum="EFCAB3476B26C736" modified="2011-10-19" version="1">MHVALQSHATLTGSRAGKPRDQYGERGCKEHKDSSDAHQLATKSNPVSTTHQVKHPFGPPLKMQLSLVCALMGVVSIAVGAPVEKLPVGVDSYSTRSAWHRPPISGHAEVEGEDDAVKRAAEAEEATIDCYSTRSRWANVKRACDHPPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBI6</accession>
    <name>F9XBI6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_72679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852416.1">
        <property type="nucleotide sequence ID" value="XM_003852368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBI6"/>
    <dbReference type="GeneID" id="13394174"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72679"/>
    <dbReference type="eggNOG" id="KOG1207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="F9XBI6"/>
    <dbReference type="OMA" id="VFGPMLC"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="270" mass="28257" checksum="41A7B67495DF356D" modified="2011-10-19" version="1">MALSSRLAIIVGGLGGIGTVTAQLLRSQGAKVALLYAPFEAKNVQSTLSKHFPDSSPSSSTDITTYECDIASHSSVQAAFAQIKSDAVAFPAILINTAGIVNLAPLESFPADDALQHLIINTHGPFLTAQAFANLYFSARDEASKSSSSNPILGGRIVNLASQAGHVALHNHGPYCASKAGLIGLTKCMASEWGPRGITANSISPGPVWTELGKKAWADPEARGKYEASVPTGKFAEPHEVARIVSFLVQDDALNINGTDVRLDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBN9</accession>
    <name>F9XBN9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852682.1">
        <property type="nucleotide sequence ID" value="XM_003852634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBN9"/>
    <dbReference type="GeneID" id="13397004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104440"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.268"/>
    <dbReference type="eggNOG" id="ENOG502SD3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112553_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBN9"/>
    <dbReference type="OMA" id="WKHAISF"/>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="155" mass="16580" checksum="71C5E7814C2A115D" modified="2011-10-19" version="1">MSARGGAGNILAASQQKAHTFTDLEANAPLSEHVTTVPFDTNREYAHSGRGGAGNYYSPKDLSQKGEFDVSERKEKDESVAVPGSAPVKVGRGGAGNFTFGKSGEGEEEKRRKEEEEKGKVVDIEREVEEGVGKLQMPEKAKLAGGERDLVNSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCS5</accession>
    <name>F9XCS5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_43706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851937.1">
        <property type="nucleotide sequence ID" value="XM_003851889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCS5"/>
    <dbReference type="STRING" id="336722.F9XCS5"/>
    <dbReference type="GeneID" id="13401289"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43706"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="InParanoid" id="F9XCS5"/>
    <dbReference type="OMA" id="AHLYVMA"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50747" checksum="26F8C3D1B68DD721" modified="2011-10-19" version="1">MNASELVSQLELRVLLRYSGPLIPSYLLQYSFTIIVTLVASQLSTDELAGCSLGMTTSNIIGYAIFEGMATALDTLCSQAYGSGRFSDVGMAMIRFLVFVHLVAIPIGGLWLFSEAILRRLVPSEELAVHAGSFLRYSLIGLPGYASFEAGKRFMQSQGQFTAGLWSLLICLPINIGLTYALVLKADMRVAGAALAASLTNLIRPLILIGYAFITDRTTLQCWPTTKEIRSSWSKDWSPMCRLALSGTVMTLSEWLSFEILTFALTYLGNAPLAAQTFLSTTATLVWHIPFSISIAGSTRIGQLVGGGLTHGSALRIMKMYAAIFAFNGILNVALGIGIVAIMLRFLINDQEVADIVLVNLPFLGVFLFCDAIVLWPHSVVRGIGWQSIAAYTTLGAAYLYGVPLALFLELGSPRLGVSGLWIGLASAVFFTCIIEASVVWTRLRRYPGKCFDEYEGASEEQTLIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV9</accession>
    <name>F9XCV9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_43919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851403.1">
        <property type="nucleotide sequence ID" value="XM_003851355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCV9"/>
    <dbReference type="STRING" id="336722.F9XCV9"/>
    <dbReference type="GeneID" id="13401386"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43919"/>
    <dbReference type="eggNOG" id="ENOG502S31Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="InParanoid" id="F9XCV9"/>
    <dbReference type="OMA" id="WHRRFIF"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="347" mass="38415" checksum="95400B59F95C4126" modified="2011-10-19" version="1">MIATSSSRTSSRKAQYWFPVLILALTCLGTGFLAGEFIQDHNLLARLNLDALATSQCTAPSFRREWRSLSSEEKIAYTDGVKCMLSRGSKHEQNASAGIYHDFTRIHATHAKAVHGAAAFLPWHRYMLHLFEAEMRTTCGYKGSLVYWDWTLDWEALQDAPVFTEQLGFGGDGNAAAHESVGDGNCVTDGAFANLTLFFHSLGEKEHCLSRSFADGKIRGRMAGDQLRPQAIEGILLQPNYESFLDSIVKGPHNQIPNGIGGDFLTFTAPNDPLWHLHHSQLDRLWWLWQQATHPPRLGSYGGAKRKGSLDKANLKDVISVGATLGPDVEVADLMSTSSSLLCYRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCY4</accession>
    <name>F9XCY4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851914.1">
        <property type="nucleotide sequence ID" value="XM_003851866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCY4"/>
    <dbReference type="GeneID" id="13393691"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93763"/>
    <dbReference type="HOGENOM" id="CLU_1653537_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCY4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17645" checksum="479DE125F0607E3D" modified="2011-10-19" version="1">MDGKTTENVVRHFIPSLGHPSLTRRDLPVATGNSNMPTQPRQGTVTSLAEKDAAPSASPKRRLSRHMSACILNMLKDDSQDEEWHRCRKGKDRVTFATIRANPATIRANPTREYAKRDIASSAVPIVNGKPAAQLIGRPALSFVFLEAPVWLVVLKLVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDF8</accession>
    <name>F9XDF8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_43138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851835.1">
        <property type="nucleotide sequence ID" value="XM_003851787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDF8"/>
    <dbReference type="FunCoup" id="F9XDF8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDF8"/>
    <dbReference type="GeneID" id="13401572"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43138"/>
    <dbReference type="eggNOG" id="ENOG502SCBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094309_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDF8"/>
    <dbReference type="OMA" id="NAPNPKT"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="15118" checksum="BD8576A7CCECFAC3" modified="2011-10-19" version="1" fragment="single">QFFTRLTTLLEKTQQAGHGSIYLTQKRLTFDTASAPSPPTGKVADDPLWDTHPPNPLPIIVRATDGNSQSKDRKKKDKVKLSTIVQPDDLETFFARYAEVCKTGMQSLKKRDRSKRKKDKSKKKKTTTGPETTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDT2</accession>
    <name>F9XDT2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CPD2401</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_44387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851572.1">
        <property type="nucleotide sequence ID" value="XM_003851524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDT2"/>
    <dbReference type="FunCoup" id="F9XDT2">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDT2"/>
    <dbReference type="GeneID" id="13402134"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44387"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001867_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDT2"/>
    <dbReference type="OMA" id="CPLEKLW"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="84"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="880"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP86548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1191" mass="132839" checksum="58FBD98145545A20" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDZ3</accession>
    <name>F9XDZ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851606.1">
        <property type="nucleotide sequence ID" value="XM_003851558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDZ3"/>
    <dbReference type="GeneID" id="13401741"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109977"/>
    <dbReference type="eggNOG" id="ENOG502S65Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660918_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDZ3"/>
    <dbReference type="OrthoDB" id="3656308at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391578" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="123"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="328"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="416" mass="44267" checksum="72352EFA5FF8CBD1" modified="2011-10-19" version="1">MFTKACGQIICLVLLISAHLAQSAATLDSQQCTQGVYKFLVPALSQDSNVHSFCDQLPTRAKFSASKGPKSLRSLAYPGVQTFCACLKKACATPSCPRGTTLCPETCGGCCANFNTDARHCVCERPTSMEEHSVEPAAAESLAVSAMEKLLSEPLIDQCREACANSGDGVTSCYAYDYDYFRSECRFYSSTVESTADSDHEYGVTVARASAVSPSSYTEGSFCIGGFLISRTCGRRISLSDSPEPVGQTNVDDCAAACVKEGGYSCFSYEFDFASNECSHYQSGPIETVPDPDYAYGALQSPYICSEPTTTPNPPAPALPGCVTKNICTNGLDFNQFCGSRITAGSMGNASYGYFSVDDCRVACARLPGASGSGLPGCTAFDYDYVSFKCQFYTSPNGLSTVPDGYHVYGYVDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEV2</accession>
    <name>F9XEV2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850863.1">
        <property type="nucleotide sequence ID" value="XM_003850815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEV2"/>
    <dbReference type="GeneID" id="13397736"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94736"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.690"/>
    <dbReference type="HOGENOM" id="CLU_1246219_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEV2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="222" mass="25419" checksum="B34B0CAC440DE23B" modified="2011-10-19" version="1">MSSPADPSSSSATVDTNPPTETFEEMKKQMLQHRAEEHYIMKRHGQTIDAEMMSRRSKDNFGLPAWKAHRDEVKACIRNLENGGEHNGDEIHARVLEILRAYVRDPGPWDMYLDCLKKRGDEANRRCFKLSHANIENAVLCRRKAEVDHRKAITNHDLFVRTVDGVSDKTKTGTCAMARFFGGKPHEGGDRAKRARGNRFSRSCESTQEVHMYELISKFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGC0</accession>
    <name>F9XGC0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_45585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGC0"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45585"/>
    <dbReference type="eggNOG" id="ENOG502SGSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204430_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGC0"/>
    <dbReference type="OMA" id="VMIKRDS"/>
    <dbReference type="OrthoDB" id="3623799at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="61" mass="7156" checksum="BBD3F73F5578D44E" modified="2011-10-19" version="1">MINRDSRGHPYSIVRGEILGFIEDELLRKHLPRMFSLISERKLGDRRRSDTVVVLTINYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGM1</accession>
    <name>F9XGM1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851036.1">
        <property type="nucleotide sequence ID" value="XM_003850988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGM1"/>
    <dbReference type="GeneID" id="13397549"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110285"/>
    <dbReference type="HOGENOM" id="CLU_280362_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGM1"/>
    <dbReference type="OrthoDB" id="3644668at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395504" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="117454" checksum="E2CB642A5ADAF573" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH93</accession>
    <name>F9XH93_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">chitin deacetylase</fullName>
            <ecNumber evidence="6">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MgCda2</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_30112</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="6"/>
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        <property type="protein sequence ID" value="EGP85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003850385.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13402787"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30112"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030200_0_2_1"/>
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    <dbReference type="OMA" id="GMEPIIW"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chitin catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="272"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="29944" checksum="F548866763A252E8" modified="2011-10-19" version="1" fragment="single">ASAIPTPQSDSPSAYPPGWAVPPTDSAVVQQYIAQIDWNWVRNNISQTTSQYCDPATDPESVALQWENCWWSCNQCRWESDVYVCPTKGEWGLTFDDGPTAATPELLDELASDGTTATFFVTGTQILLFPDTLRRIANEGHEIGIHTWSHAALTTLSSDQIVAELGWTLTIIADTLGYTPSVSLFRPPYGDVDNRVRDIAVQLALTPALWSHDTNDWKLNEDPANQPMLEGELDVIVQSAWGSETGIVTLQHDSTAAVVRYAIDVVLPRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH99</accession>
    <name>F9XH99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_110410</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH99"/>
    <dbReference type="FunCoup" id="F9XH99">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH99"/>
    <dbReference type="GeneID" id="13395006"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110410"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="InParanoid" id="F9XH99"/>
    <dbReference type="OMA" id="KSIMACA"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="73"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="363" mass="41153" checksum="BB1D095BF1BF7473" modified="2011-10-19" version="1">MPSATKHNLTEDDIYRTSTQYRFWSFSPEQLSARRKETHRLALQRAAQYTQNDASTEHLTLEEELRLVTRYAELLRTTSDHLKWPANIKSTAIQYLRRFYLSNSCMTYPPKEIYKTVLFLASKTEAFHITLSKFCSMISADPEAVLAPEYKVMQALRFTLDVRQPFRGLKGVLMELINLVDEERDGLKDLKPPEGGATSWKPPPGGKMEKKHMNDRVQAAYAAARNMLDAPASLTDAYFLYTPSQILLASLLLADEPLYECYLGTKLTLDSPTRPKILGTIQDCAQLMSSYDSKASMTKEERAELEKKLEACRDPSTKDMVKNHAAMKLNADDDDSDAKRKKAEKQQKTRAADDMFGPSLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHB5</accession>
    <name>F9XHB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_75187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850223.1">
        <property type="nucleotide sequence ID" value="XM_003850175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHB5"/>
    <dbReference type="FunCoup" id="F9XHB5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="GeneID" id="13394576"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75187"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.708"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057354_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHB5"/>
    <dbReference type="OMA" id="AHTMYAV"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="113"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="29145" checksum="D8350AD8405E7A63" modified="2011-10-19" version="1">MKTPSPSFVCASCARSLRQQLPKQTTFARAFASETTTPRTRGLPSAADLPPHRDNDQPRWKSTPPAMKMPVRLRPEPSQPVWVVNRDEEKVNAVFDAFLGPLAGKQKGRELLDEETKWLTLTHKSFEHGRQGFNARLSFLGRRILTLQTSLALLRAPSPPNLSSLPANEVFYHPSLTGLENISPVTKDQVLDKKRLANIARQYGMEKVVRWKPARSDKLVESGQEAVLAQAVYAVVGAVALRLGGDVAGRVARERVLEPLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHI1</accession>
    <name>F9XHI1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_74671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850416.1">
        <property type="nucleotide sequence ID" value="XM_003850368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHI1"/>
    <dbReference type="FunCoup" id="F9XHI1">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHI1"/>
    <dbReference type="GeneID" id="13394994"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74671"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.313"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="InParanoid" id="F9XHI1"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="590" mass="65858" checksum="D8923FD56845C8A4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHI2</accession>
    <name>F9XHI2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_61514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850010.1">
        <property type="nucleotide sequence ID" value="XM_003849962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHI2"/>
    <dbReference type="FunCoup" id="F9XHI2">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHI2"/>
    <dbReference type="GeneID" id="13394993"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_61514"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.314"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="InParanoid" id="F9XHI2"/>
    <dbReference type="OMA" id="HLMQVMD"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="293" mass="31901" checksum="6B29B5910BE4CD62" modified="2011-10-19" version="1">MSEELLDEVTSINSIYGESTIIPLDEISGLFALTLPARPEIVLRLEFPSNYPDAPPSILGTQSVGNDVAKGEGTHVVDIVRDVLSEIYAPGAACVFDLIEESGQRLEQLGLDQVSKDEEQQAAQRNGQDESHEVPNASVSDYQQSVDDLGDPPPWTLSEVVSEKKSIFVARSAPVCSVDEAKSYLAHLLATDKKVAKATHNITAWRIRGDNGTQYQDCDDDGETAAGGRLLHLLELMNVWGVMVVVTRWYGGVQLGPDRFRIINQCARDAVVKGGHAAQEPYSKDAGKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XID7</accession>
    <name>F9XID7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S1/P1 nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_110348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850497.1">
        <property type="nucleotide sequence ID" value="XM_003850449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XID7"/>
    <dbReference type="STRING" id="336722.F9XID7"/>
    <dbReference type="GeneID" id="13402713"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110348"/>
    <dbReference type="eggNOG" id="ENOG502QRXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044365_0_0_1"/>
    <dbReference type="InParanoid" id="F9XID7"/>
    <dbReference type="OMA" id="GYRLANW"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391684" description="S1/P1 nuclease" evidence="9">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40055" checksum="216E0DDF10A778CA" modified="2011-10-19" version="1">MRLPLVLALPLPGVLAWGNLGHQTIAHLASTLIHPSTTTWAQTILNDTSEAYLATISTWADTYRRTAEGAFSAPFHYIDANDDPPRSCGVDFERDCLGEGCVVSAIANYTRRVMAADVLDAKEVDYALRWIVHFVGDITQPLHDEAVEIGGNGINVTFSGRKTNLHASWDTAIPEQLRGGYTLADAKAWAENLTAELAPRGKFGRVKEGWVKGMNVDDPKETAMIWAKDGNSFVCDTVIPEGVEGVEGEELFPAYYEGVVDVVEMQIAKGGYRLAKWLDGIAESVEGKKGRKGVKKDGPGPKAPGKGKGLGPKRSVEESVEEEWDLSGRDLLPEGAGVRGLLSPAQRRREAVLGSGDLYIPRLSTKTGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIM6</accession>
    <name>F9XIM6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850285.1">
        <property type="nucleotide sequence ID" value="XM_003850237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIM6"/>
    <dbReference type="GeneID" id="13394396"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95325"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.565"/>
    <dbReference type="HOGENOM" id="CLU_1012686_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIM6"/>
    <dbReference type="OrthoDB" id="3650500at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="275" mass="30513" checksum="D1AD331D12592227" modified="2011-10-19" version="1">MAGAKVFAVPELLENILLQCADTAIIDQLERPEGVSASTEPLRSLAPCHRVSRAFNNVLIGSCKLQQLMFGDSNPSYDGVSLPKSAPIVWLLAVQEKVFECWGQGANEEADFIYSIDFRHPAISTAPKGLRAREASWRRVKCHRGAGNDSKPLMGYFKSVSCNSTSPYDSERFLDVVEMHGDCTLGTFADWLDNSAFSGHEEEYQISVDYLYGYDAPLEPIKRGERGTLKKPQVLRESAPKEVLDEKHSDAGSPEGKEIVEKRPEENQSAEEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIP5</accession>
    <name>F9XIP5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850276.1">
        <property type="nucleotide sequence ID" value="XM_003850228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIP5"/>
    <dbReference type="GeneID" id="13394406"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105575"/>
    <dbReference type="HOGENOM" id="CLU_2514382_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIP5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="85" mass="9426" checksum="61B22644F0151E0A" modified="2011-10-19" version="1">MGDPILEIRLRQDNAVEEEHHLQALVVDIAMNAAMSAARTITAADVRRHGVHLAESLKCRQADRMTVTIAAITMVGEVRMYDPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJC4</accession>
    <name>F9XJC4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849654.1">
        <property type="nucleotide sequence ID" value="XM_003849606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJC4"/>
    <dbReference type="GeneID" id="13402248"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105754"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.418"/>
    <dbReference type="eggNOG" id="ENOG502TGEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442271_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJC4"/>
    <dbReference type="OrthoDB" id="3935322at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="81" mass="8909" checksum="5DB08D54ABDB7C16" modified="2011-10-19" version="1">MARMASSKFVEILDTRDLPYSRENVSLEDVLAAHRSRTGSQDSLNTTASSKSSSPTSPTYHSAPMNPLKTGLRRLSIMKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJW4</accession>
    <name>F9XJW4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_87466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849749.1">
        <property type="nucleotide sequence ID" value="XM_003849701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJW4"/>
    <dbReference type="GeneID" id="13399061"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87466"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.237"/>
    <dbReference type="eggNOG" id="ENOG502S2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_4_0_1"/>
    <dbReference type="InParanoid" id="F9XJW4"/>
    <dbReference type="OMA" id="TPFPACK"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="21792" checksum="906000DC22CA0C68" modified="2011-10-19" version="1">MAFNASDKSSPGAYTASQTALLLLDFHEQFVNVAAGDLGKRAASIAVNMRHWAHTQGIQVIHAPLDLESTPVETYKDRDRLIGLLETLRQEGGSEPAALLDGDEGDVTLTRRLGQVSAMGSPGLQEYLMEKGIKSLIMTGLSTSGCVLWTALSASDLGFIVTTMSDACADPKPGAHDLLVTQVLNNRGWVMTAAEFQEGFGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK10</accession>
    <name>F9XK10_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_20590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849620.1">
        <property type="nucleotide sequence ID" value="XM_003849572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK10"/>
    <dbReference type="STRING" id="336722.F9XK10"/>
    <dbReference type="GeneID" id="13402417"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20590"/>
    <dbReference type="eggNOG" id="ENOG502QQPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004261_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK10"/>
    <dbReference type="OMA" id="IMFLPHI"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="88412" checksum="4785243602FAC2F4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK32</accession>
    <name>F9XK32_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_101297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849508.1">
        <property type="nucleotide sequence ID" value="XM_003849460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK32"/>
    <dbReference type="STRING" id="336722.F9XK32"/>
    <dbReference type="GeneID" id="13402405"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101297"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK32"/>
    <dbReference type="OMA" id="PQACLYQ"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="4">
        <location>
            <begin position="497"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="1264" mass="140772" checksum="DDE5EE5DF0118657" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKA6</accession>
    <name>F9XKA6_ZYMTI</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="866" mass="95175" checksum="3A5DCDDB2B121175" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP3</accession>
    <name>F9XKP3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848851.1">
        <property type="nucleotide sequence ID" value="XM_003848803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKP3"/>
    <dbReference type="GeneID" id="13398021"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96190"/>
    <dbReference type="HOGENOM" id="CLU_1636755_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKP3"/>
    <dbReference type="OrthoDB" id="10577961at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="16916" checksum="F224257968417B3E" modified="2011-10-19" version="1">MTVTNTVFVNPPTSTNSVAPKVNSTSICHSAAALSTSLAGLITQIPDGQIQGPVPSTMSLPPGAPPGVPQGVPQGVPEGTSRGLPSGWPYPGVLSVPPHSLHGNATITKAHGIPKPSHYSMPPHSYRGNVTVPQTRRPKMTLRGNGTASFTTVTMTKHWRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKT2</accession>
    <name>F9XKT2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_48517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849020.1">
        <property type="nucleotide sequence ID" value="XM_003848972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKT2"/>
    <dbReference type="STRING" id="336722.F9XKT2"/>
    <dbReference type="GeneID" id="13398342"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48517"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.507"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="InParanoid" id="F9XKT2"/>
    <dbReference type="OMA" id="ISCKHYA"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF17">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="377" mass="39894" checksum="988EEF7DDE582D55" modified="2011-10-19" version="1">MPKINVARLVEIGKPFEVGTADKPTPGPNDVLVKVEACCLVPNSSNIVSGGTDSDVFTLPQLPTVFGLDAAGVVEAVGERFFNIRAGDRVYVDPHLTCGTCHQCRRGRTDICENTCLRAYFAMCPGGVKMLTHYPLGALSEYLLSPDVNIAKLPDSIDLATASRFGYIGTSFGGLKTAQIQPGKTLLINGVTGTLGYAAVAIALGLGCMRILGIGRNKERLAELENLCHKGRVRTICSEDGGIDAVTEWVSEQTDGLDPDALYDCLGNGGDAYTTSRLAGTVTRGGIAVLAAGGAEGELRQTYLEAMSRDVAILGTMWFTSAEVDELIALIDAGVIDFSFLGHEFFPLKKVNEAFEMVGNRPGGAVNVVVQPSKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKW7</accession>
    <name>F9XKW7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_96433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849005.1">
        <property type="nucleotide sequence ID" value="XM_003848957.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="406"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="776" mass="85044" checksum="61D080D808167034" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL14</accession>
    <name>F9XL14_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_101353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848727.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.81"/>
    <dbReference type="eggNOG" id="KOG2916">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
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    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
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        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="307" mass="35064" checksum="83FEB9939F3796F1" modified="2011-10-19" version="1">MSLTNCRFYEEKYPEIDSFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDIIKCEERYNKSKMVHSIMRHVAEKANVPIEELYQDIGWPLNKKYGHAVDAFKLSITNPDVWSEVKFKNNVIRDELQSYIGKRLTPQPTKVRADIEVTCFGYEGIDAVKRALRCAEAKSTEDTQVKVRLVSPPLYVLTCTTVDKSNGIEVLEEAIREVDASIKNEMGTCMVKMAPKAVTENDDAELQALMDKKEKENMEVSGDEDSESEDNVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL65</accession>
    <name>F9XL65_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849114.1">
        <property type="nucleotide sequence ID" value="XM_003849066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL65"/>
    <dbReference type="GeneID" id="13398586"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105961"/>
    <dbReference type="HOGENOM" id="CLU_2127123_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL65"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="114" mass="13153" checksum="F1D509DC7B3222DE" modified="2011-10-19" version="1" fragment="single">TKPWSPQAPQASTTILRIRSRFNYHKTTYHTTTTNVTANTYQHVVDSRLLRVRHILHQHLFECQLQDPTAQEESHIEVQVKSGRLSFARREASRSKERTGQQRHSGLASCSEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLH6</accession>
    <name>F9XLH6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_48587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848918.1">
        <property type="nucleotide sequence ID" value="XM_003848870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLH6"/>
    <dbReference type="FunCoup" id="F9XLH6">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLH6"/>
    <dbReference type="GeneID" id="13398484"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48587"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.371"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="InParanoid" id="F9XLH6"/>
    <dbReference type="OMA" id="FQAIMDF"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="276" mass="30420" checksum="49DF14880FAD0AEB" modified="2011-10-19" version="1">MNAKPASLPEITCEFRGRVAILTINRTKKLGALSQDLYFNIAQWLRHIDGREDIYITVLAGTGRFFSAGADVSVAGQNKGAKEDLFRTNLQNFAAYNLNITHAFYSHSKILVTALNGPVVGLSAAIIGHSDFIYAAPHAYLLCPFTSLGLVSEGLASRALAGRLGPARGAEALLMSKRITCEELVQCGFVNKVFQTKPEESKKFLDLVLEEVDNRLGEHLVPNSLIKIKQQMRGPERDLYDAQGVKEVFGGLDVFMRGIPQEEFRKVASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLX3</accession>
    <name>F9XLX3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849040.1">
        <property type="nucleotide sequence ID" value="XM_003848992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLX3"/>
    <dbReference type="GeneID" id="13398284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96374"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.471"/>
    <dbReference type="HOGENOM" id="CLU_352740_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLX3"/>
    <dbReference type="OMA" id="NTHCNIL"/>
    <dbReference type="OrthoDB" id="3641224at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="797" mass="89566" checksum="A63AC23EE76DFF54" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM40</accession>
    <name>F9XM40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_88113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848443.1">
        <property type="nucleotide sequence ID" value="XM_003848395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM40"/>
    <dbReference type="FunCoup" id="F9XM40">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XM40"/>
    <dbReference type="GeneID" id="13396441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88113"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_3_0_1"/>
    <dbReference type="InParanoid" id="F9XM40"/>
    <dbReference type="OMA" id="ISTMRWR"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="183"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="449" mass="50686" checksum="80580AA22794BF35" modified="2011-10-19" version="1">MAQEMPPGRPGNLTPEQETKLKEMWAALLDLCGVSHEQNGTAAAVSSPTPAPRETPDKKTKKSRLSLFGKKDKEIADSEPASGVDNDKHGQTKEFQQALASLSPEALRDALWSMSKHDHPDALLLRFLRARKWDVQAALVMLIATMHWRSQEMHLDDEIMMQGEGHAVRQANSSDPAEKKEGEDFLVQMRLGKSFLHGVDKEGRPCCYVRARLHHGGEQSEKSLERLTVYTIETARMLLRPPVDTATIVFDLTDFSMANMDYTPVKFMIKCFEANYPESLGSVIVYKSPWLFQGIWKIIKGWLDPVVAGKVHFASNPNDLEQWIPREHMMKELGGDEDYVYQYVEPKEGEDVEMAKTAEKEPILAERKELVDSFESETISWMHGNDAGEGRLRLAQRLAENYWKLDPYVRAKSVYDRTGVLGPKGELNFYPEEKKPVSASAGGAHDELD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2025-04-09" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMW3</accession>
    <name>PKS1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Non-reducing polyketide synthase PKS1</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Conidial pigment biosynthesis cluster 29 protein PKS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PKS1</name>
        <name type="ORF">MYCGRDRAFT_96592</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="G3 (Bethesda)" volume="4" first="2519" last="2533">
            <title>Quantitative trait locus mapping of melanization in the plant pathogenic fungus Zymoseptoria tritici.</title>
            <authorList>
                <person name="Lendenmann M.H."/>
                <person name="Croll D."/>
                <person name="Stewart E.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="25360032"/>
            <dbReference type="DOI" id="10.1534/g3.114.015289"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="631" last="631">
            <title>In silico prediction and characterization of secondary metabolite biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.</title>
            <authorList>
                <person name="Cairns T."/>
                <person name="Meyer V."/>
            </authorList>
            <dbReference type="PubMed" id="28818040"/>
            <dbReference type="DOI" id="10.1186/s12864-017-3969-y"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 11 12">Non-reducing polyketide synthase; part of the gene cluster 29 that mediates the biosynthesis of mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:25360032, PubMed:28818040). The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase PKS1 though condensation of acetyl-CoA with malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>6 malonyl-CoA + acetyl-CoA + 6 H(+) = naphtopyrone YWA1 + 6 CO2 + 7 CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:62652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:133763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:62653"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="3">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Pigment biosynthesis; melanin biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal region is involved in Claisen-type cyclization of the second ring of naphthopyrone.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848644.1">
        <property type="nucleotide sequence ID" value="XM_003848596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMW3"/>
    <dbReference type="SMR" id="F9XMW3"/>
    <dbReference type="STRING" id="336722.F9XMW3"/>
    <dbReference type="ESTHER" id="zymti-pks1">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="Mycgr3T96592">
        <property type="protein sequence ID" value="Mycgr3P96592"/>
        <property type="gene ID" value="Mycgr3G96592"/>
    </dbReference>
    <dbReference type="GeneID" id="13396530"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96592"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.184"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_0_1"/>
    <dbReference type="InParanoid" id="F9XMW3"/>
    <dbReference type="OMA" id="YCRGDGC"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00785"/>
    <dbReference type="PHI-base" id="PHI:8593"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="PHI-base"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0470">Melanin biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000451090" description="Non-reducing polyketide synthase PKS1">
        <location>
            <begin position="1"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="369"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="6">
        <location>
            <begin position="1666"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="6">
        <location>
            <begin position="1801"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)," evidence="5">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="5">
        <location>
            <begin position="900"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Product template (PT) domain" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1452"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1640"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1766"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1879"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Claisen cyclase domain" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1643"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1774"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1889"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <feature type="active site" description="For acyl/malonyl transferase activity" evidence="9">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1512"/>
        </location>
    </feature>
    <feature type="active site" description="For Claisen cyclase activity" evidence="1">
        <location>
            <position position="2002"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1703"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1838"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q03149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5B0D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9Y8A5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="W3X7U2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="25360032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="25360032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="14">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="25360032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="16">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2175" mass="235713" checksum="FBC387368E22C265" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMY0</accession>
    <name>F9XMY0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="3">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPM1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_88000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848341.1">
        <property type="nucleotide sequence ID" value="XM_003848293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMY0"/>
    <dbReference type="FunCoup" id="F9XMY0">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMY0"/>
    <dbReference type="GeneID" id="13396134"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88000"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.207"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_1"/>
    <dbReference type="InParanoid" id="F9XMY0"/>
    <dbReference type="OMA" id="MLPYWYD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="230" mass="26109" checksum="7AD682D39A33852A" modified="2011-10-19" version="1">MPAPYKLIILRHGRSEWNEKNLFTGWVDVPLNEQGIKEATQAGKLLKKHNYLPEILFTSLLRRAIVTADLALDEADRLWIPVKRSWKLNERHYGGLQGLDKAEAAEREGAEQVHIWRRSFDVRPPATSEEYRKSEDEGGRYASQGIEVPATECLKDVLVRVLPYWTEDIVGELKKGRTVLIAAHGNSLRALMKELEGISDEDIPGVEIPTGVPIVYELDEEFKGKGRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN65</accession>
    <name>F9XN65_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_96686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848382.1">
        <property type="nucleotide sequence ID" value="XM_003848334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN65"/>
    <dbReference type="FunCoup" id="F9XN65">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN65"/>
    <dbReference type="GeneID" id="13396268"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96686"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.300"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="InParanoid" id="F9XN65"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="27240" checksum="77283CBBBA248ED6" modified="2011-10-19" version="1">MDDDEVLQLPADTLRLLQEFNTEKDARAKQFEELKSKAESDFEGKLSMDFFGEDWNASQFWYTDETARTLARQLLKDATKDSAIAVVSAPSVYVALTNILAEESELPRPKLCLLEIDTRFEVLGSDFDYYDFEQPLRLPAELKGKFDRIICDPPFLSDDCQTKTALTVRFLAREWSESGLRFISCTGERMEATIIKLYAKIGVKTTGFEPKHSKGLSNEFWCYSNFQCEDWRWRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN92</accession>
    <name>F9XN92_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_88062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848397.1">
        <property type="nucleotide sequence ID" value="XM_003848349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN92"/>
    <dbReference type="STRING" id="336722.F9XN92"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="GeneID" id="13396416"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88062"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_3_1"/>
    <dbReference type="InParanoid" id="F9XN92"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="205" mass="22568" checksum="178177558D5A0A5E" modified="2011-10-19" version="1">MPMPFVTETVGGGWHTSDIFSRLLKERIICLNGEVEETTSASIVAQLLFLEAENPQKPISLYINSPGGSVTAGLAIYDTMQYIAAPVTTICLGQAASMGSLLLCGGAPGQRFCLPHSRIMVHQVSGGYHGQASDIAIHAKEILRVREQLNRIYQRHLPVKKELEEIEKVMERDFFMSADEAREWGIVDKVLDRRPGAEGGEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN93</accession>
    <name>F9XN93_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_49912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848579.1">
        <property type="nucleotide sequence ID" value="XM_003848531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN93"/>
    <dbReference type="STRING" id="336722.F9XN93"/>
    <dbReference type="GeneID" id="13396164"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49912"/>
    <dbReference type="eggNOG" id="ENOG502R0AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801024_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN93"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="146" mass="16906" checksum="A58AB07079321202" modified="2011-10-19" version="1" fragment="single">MIDSTPIPQLPDRAGVLEQGNVLTLRDQEAKLDQIQKDNFSLKLKIHYLEEALRKSGNEFHQATLKENNERTMEVRQLQRELEVAKSSSAGNIDDVQHRMESMKAELEREHKEAKQALEDEIEAFVTHFKIADAEQAELKRELERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNF1</accession>
    <name>F9XNF1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847884.1">
        <property type="nucleotide sequence ID" value="XM_003847836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNF1"/>
    <dbReference type="GeneID" id="13401473"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106282"/>
    <dbReference type="HOGENOM" id="CLU_1109299_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNF1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="251" mass="26347" checksum="14AC72FD4A3B2763" modified="2011-10-19" version="1" fragment="single">MAATSTINFSRPWGPSTTFASPPARISSLSPVLEQTEAPSGHNLSAPCHDRVSSSTTSIQSDCKRLRIAESNTCRNPMPNRTSSESTVKRSRSSSGASSRSGGKAAPRLSPWPTIRRDSGIVNNIPPTPRSPTTKLSPPPSIYSKFNPDQVFSRPVAGPRTSSTGAVAAIHPLPLARPHSSPAPTTSPSQISRSRSASAVSSPSASSGRRASMIRLKSILKVTSVSQYTTNADGSSTVCRTSALSNASNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNI7</accession>
    <name>F9XNI7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 62 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_77320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848184.1">
        <property type="nucleotide sequence ID" value="XM_003848136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNI7"/>
    <dbReference type="GeneID" id="13401764"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77320"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_2_1"/>
    <dbReference type="InParanoid" id="F9XNI7"/>
    <dbReference type="OMA" id="WVESDKG"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46174" checksum="E8269723DE57040D" modified="2011-10-19" version="1">MLLPKSAGEGGGMTWKSARARLPPTRAVWTFLTRTRFLLFVGLAGIALIIWNGVRGSASDWQRFYCFGPAKSPMQMTANEQAMWAGHQQTPVIFNHHEPIEVNSSTIQRVDLNPIVSTPKALANEERVLILTPLRNAAPYIEQHFDLLTQLTYPHRLIDLAFLVGDSTDDTVAVLAMELDRIQSPQDSNSFRSAMIVEKDFGVTVGQDVEDRHGFAAQGPRRKAMGKARNYLLSTALKPEHSWVYWRDVDIKDSPSKIIEDFVAHDRDVLVPNVWFHRYKDGVDIEGRFDYNSWQESDQGRKLAASLDKDVVLAEAGYKEYATGRKYMARMGDWRDNKDIEIPLDGIGGVNIIVKADVHRAGINFPCYAFENQAETEGFAKMARRAGYGVYGLPNYVVWHIDTDEKPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNU1</accession>
    <name>F9XNU1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_97077</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848133.1">
        <property type="nucleotide sequence ID" value="XM_003848085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNU1"/>
    <dbReference type="GeneID" id="13401934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97077"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.247"/>
    <dbReference type="eggNOG" id="ENOG502RDF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2252185_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNU1"/>
    <dbReference type="OMA" id="VAAREIN"/>
    <dbReference type="OrthoDB" id="10386253at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390952" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="104" mass="11084" checksum="907A772BDDAD0A15" modified="2011-10-19" version="1">MHATTAVIALLSALAIARPAPSEVNGDDLWGNCAGWTPCQDVVRIAEGCGTAKTEGGDVFSKPSWVQCTCSKIKPKQLEDCSSVCLEYFREGGDLKKLKDACGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP64</accession>
    <name>F9XP64_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_111549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP64"/>
    <dbReference type="FunCoup" id="F9XP64">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="GeneID" id="13402096"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111549"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.379"/>
    <dbReference type="eggNOG" id="ENOG502SFX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013723_1_0_1"/>
    <dbReference type="InParanoid" id="F9XP64"/>
    <dbReference type="OMA" id="ENECACM"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76136" checksum="BE8E8414EF899EF8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ90</accession>
    <name>F9XQ90_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="178"/>
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        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="183" mass="20412" checksum="4FC5A816101931DC" modified="2011-10-19" version="1">MTSSDDKTNLFPQYSSQLVGTWKCISFHLYAVPSNPSPSNPHGDLLSKPQGDSPLGRLSISPTGWLAVHSSTPSSLGGLKSGKSWHAAPEEEVALVARGLTMYCGYLEVFEDEEEGQVWWRTRVEVAADPGMIGGKEERRVRFEREDGEGRDVMVLEPMKEYEVEDGTKARAVLKWVRMDPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847429.1">
        <property type="nucleotide sequence ID" value="XM_003847381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQR9"/>
    <dbReference type="STRING" id="336722.F9XQR9"/>
    <dbReference type="GeneID" id="13400358"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51613"/>
    <dbReference type="eggNOG" id="ENOG502STH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068279_3_0_1"/>
    <dbReference type="InParanoid" id="F9XQR9"/>
    <dbReference type="OMA" id="HAFRIYV"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
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            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="206" mass="23050" checksum="8613D021F83C59D0" modified="2011-10-19" version="1" fragment="single">VHKERLTDSSPFFAAAMKKDWNEGQTGEILLPDDSFQQAELYVNWLYSGFLFTQDATPPCEHDSTENKTLIAAYIFGEKIQDCNYKDAIIDALICAAGTKDVEGMRWYPTGMTVDFAFDKTPEASPLRRLLLDMYLRHGHKDWVSNKNVDFLTLLAQGLFEVKASSSGPDPTASTSNSCSYHQHAKDKDCHSRKMSSRAQTGPEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR76</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97735</name>
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    <organism evidence="2 3">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR76"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97735"/>
    <dbReference type="HOGENOM" id="CLU_1225617_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR76"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
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            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="226" mass="24213" checksum="FACF076C606D5735" modified="2011-10-19" version="1">MGAELSNIKLTAEEEADCKRKGPEEGSERTTDLSTTNELLPIPADNFDAFIDFLTRTLPRGSRLGYRISPEQETKLSSTLTTALIVERFNNFQSHSAASVTTAATAPDTAVSTHGTTPSCEASSDDTSGIEEEESLVPKGVEKSMNTGKLQVNSDKGFTAQELDSRTPLTQERGTKRKAASEGGLKDLDDYKSAPDKMARHVGQDSNSVLIDAISNVSAEPEAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRP8</accession>
    <name>F9XRP8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106662</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847049.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13399470"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106662"/>
    <dbReference type="HOGENOM" id="CLU_2374392_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRP8"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="95" mass="10414" checksum="2F07D874FB372A61" modified="2011-10-19" version="1">MDLAMQLGGSFTIGRIGCALRRALSAGPLRLPSLMNIRHVIMKLNVAQSPRAVLLHSPRPPCFHHTIDLTNDHSTNYSTDPTNDHTNAVVMTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRV4</accession>
    <name>F9XRV4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP81980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847004.1">
        <property type="nucleotide sequence ID" value="XM_003846956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRV4"/>
    <dbReference type="GeneID" id="13399213"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97946"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.34"/>
    <dbReference type="HOGENOM" id="CLU_528072_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRV4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="516" mass="56890" checksum="38DD322DA5D55563" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS84</accession>
    <name>F9XS84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003846861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS84"/>
    <dbReference type="GeneID" id="13396691"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98073"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_21.4"/>
    <dbReference type="HOGENOM" id="CLU_1261292_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS84"/>
    <dbReference type="OrthoDB" id="3896145at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="205" mass="22447" checksum="D764A51A832BE0AD" modified="2011-10-19" version="1">MSGMLASIERTLSALQGGGTIYGGDVFAVLRQSLYAVRAAQFGLVDGALDCSYACDPRMTFTDRLLRLTQRQHLEPCCVLPFDMKSSTDGQAGLQAYTTTQKQRNRAAFFVGICASDPTFIELYPNYCQDSAVLQRDAASTPDAKIKTVVNTTRTCRLPPSTYGWLDPCASPYRMLIYMLPRAVEAIIACVNSSSTALEGRRTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW38</accession>
    <name>F9WW38_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_65158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855966.1">
        <property type="nucleotide sequence ID" value="XM_003855918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW38"/>
    <dbReference type="STRING" id="336722.F9WW38"/>
    <dbReference type="GeneID" id="13403251"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65158"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013294_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW38"/>
    <dbReference type="OMA" id="VFYFRAW"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58888" checksum="9D14EEF6CCD235A8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXD6</accession>
    <name>F9WXD6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_64875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857798.1">
        <property type="nucleotide sequence ID" value="XM_003857750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXD6"/>
    <dbReference type="FunCoup" id="F9WXD6">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXD6"/>
    <dbReference type="GeneID" id="13403808"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64875"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.28"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_1"/>
    <dbReference type="InParanoid" id="F9WXD6"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="37"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="202" mass="22915" checksum="68F12008CAD38510" modified="2011-10-19" version="1">MANLLQRLMRPFSSSSMHFTPETSAQTMNLPEGAQRATIAAGCFWGVEHMYRHDFKDKGLLDARVGYIGGDTDSPSYRAVCSGRTGHAEACQIIFDPTKVTYAALLEYFYKMHDPTTANRQGPDTGSQYRSGIFYHDAEQKAIAEEVTKKANEQWYKGKIVTEILEAGTWWDAEKYHQLYLQNNPGGYECPSHFLRKFPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXF7</accession>
    <name>F9WXF7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_106762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855880.1">
        <property type="nucleotide sequence ID" value="XM_003855832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXF7"/>
    <dbReference type="FunCoup" id="F9WXF7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXF7"/>
    <dbReference type="GeneID" id="13403819"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106762"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXF7"/>
    <dbReference type="OMA" id="HKKMHGV"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61319" checksum="5E1B0D26EB6C00A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXS0</accession>
    <name>F9WXS0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_35147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856101.1">
        <property type="nucleotide sequence ID" value="XM_003856053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXS0"/>
    <dbReference type="STRING" id="336722.F9WXS0"/>
    <dbReference type="GeneID" id="13403118"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35147"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.578"/>
    <dbReference type="eggNOG" id="ENOG502RFZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXS0"/>
    <dbReference type="OMA" id="PNNYFRP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="240" mass="27020" checksum="25734A8364595F25" modified="2011-10-19" version="1">MAVQTTAILVVLLILVPIYVVYKPPKLAISYFQQRFPEVLFQVNTARKIIALTIDDSPSQYTREIVDILKTNDVSATFFVIGNQVSQHPNVLAEIVASGSELGNHAMHDEPTVSLTNAALDAEIREVDGYIEQAYKTSNKDRDLHLFRPGSGVFSQRILDVVTTAGYKTILGSIYPHDPFISTWRLNAWHILSMLRPGAVIICHDRRPWTVPMLKKVVPEMKRKGYEIVSVSKFLELTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY66</accession>
    <name>F9WY66_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_102569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856399.1">
        <property type="nucleotide sequence ID" value="XM_003856351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY66"/>
    <dbReference type="FunCoup" id="F9WY66">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY66"/>
    <dbReference type="GeneID" id="13394956"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102569"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1194"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY66"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="27405" checksum="C9D61163066F0C45" modified="2011-10-19" version="1">MLQQRLLRSFLAASKQTPALPTSRISPSASQPKVAFVASQQLASRRWYSAETEAKKEEVLKEQAEAQGAQETPKKDAAKEDPVQKELEAKKQENVDLTDRLKRQIAEYRNLQEQTKREVQAARDFSLQRFAKDLLESIDNLDRALEAVPKEKLTSENQDLVNLHSGLKMTERILMGTLKKHGMEKFDPSVEGDKFDPNKHEATFMTPQPDKPDNTVFHCQSKGFLYNGRVLRAAKVGVVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY4</accession>
    <name>F9WYY4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine protein phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PTPL-1</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_31289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856041.1">
        <property type="nucleotide sequence ID" value="XM_003855993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYY4"/>
    <dbReference type="FunCoup" id="F9WYY4">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYY4"/>
    <dbReference type="GeneID" id="13403184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31289"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.445"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9WYY4"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="20785" checksum="4A9FECF79BCF0A43" modified="2011-10-19" version="1">MASGTSTPSGRQVSVLFVCLGNICRSPMAEGVFRHLTNFETSDPHPLIAAIDSCGTGAYHAGDRPDSRTLSVLKDNGLSSYKHAARKVRVPEDFEKFDYLIAMDEDNYMDLRDLVKRTKKNKGTLGDEHLDKVRLYGEFGGKDKKEEIGDPYYGGREGFTIAYEQVVRCGKGLLKEIEEKAKAEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZG6</accession>
    <name>F9WZG6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_20530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855854.1">
        <property type="nucleotide sequence ID" value="XM_003855806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZG6"/>
    <dbReference type="STRING" id="336722.F9WZG6"/>
    <dbReference type="GeneID" id="13403355"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20530"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_4_0_1"/>
    <dbReference type="InParanoid" id="F9WZG6"/>
    <dbReference type="OMA" id="IMITTYD"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="160"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="530"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="911" mass="102734" checksum="06989DACAC600BF3" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZL1</accession>
    <name>F9WZL1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_52044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857710.1">
        <property type="nucleotide sequence ID" value="XM_003857662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZL1"/>
    <dbReference type="STRING" id="336722.F9WZL1"/>
    <dbReference type="GeneID" id="13403872"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52044"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZL1"/>
    <dbReference type="OMA" id="AKQTCLG"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="157"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="27824" checksum="CAAAF8E3C64C9E3B" modified="2011-10-19" version="1">MAAAIISGLISKNFSKSQITVSEPWEVNRQKMADLGVQTTTNNLEAATGANIIILAVKPQVAKAVCEELGSSDWTGAERPVLVSIAAGITRKSLAEWSTGKDGKALPIVRVMPNTPALLGEGASGLYAGDEVSETQRKQVDALLQSVSRATEWVEKEELLDVVTGLSGSGPAYFFAFVEHLIESATALGLGREQATRLAAQTCLGAGKMLVESSETPTQLRKNVTSPNGTTQAALETLEKEGLKEIVDKAVKAATSRSEELGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZU0</accession>
    <name>F9WZU0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856056.1">
        <property type="nucleotide sequence ID" value="XM_003856008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZU0"/>
    <dbReference type="STRING" id="336722.F9WZU0"/>
    <dbReference type="GeneID" id="13403163"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89002"/>
    <dbReference type="eggNOG" id="ENOG502T3NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450714_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZU0"/>
    <dbReference type="OrthoDB" id="3650976at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="606" mass="65751" checksum="DEE9EABEBA59B567" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X089</accession>
    <name>F9X089_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_34830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856433.1">
        <property type="nucleotide sequence ID" value="XM_003856385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X089"/>
    <dbReference type="GeneID" id="13399165"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34830"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1271"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081019_0_0_1"/>
    <dbReference type="InParanoid" id="F9X089"/>
    <dbReference type="OMA" id="VECFFFD"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="218" mass="25157" checksum="7ED7CCCF818FF47C" modified="2011-10-19" version="1">MSDSSAQDEAIKARIIKHMNEQHRDSIARYLENYAKLSSFSAYDGILTDIDLGGLTLSCHGRSHRIPLEPPMKSYREARERVVQLDKECCQQLNRSDVTVKEYRSPQGFDALVFMVVSATFLAYSQRWWFEKGQVVEAILGSSFARFSRTIQPWLFWFMVALHGAETIYFASAQLSKHSVSARSRIWWLWTGSVFIEGVFAMKRFSAMVTAQREKQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0J2</accession>
    <name>F9X0J2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_67202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857022.1">
        <property type="nucleotide sequence ID" value="XM_003856974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0J2"/>
    <dbReference type="FunCoup" id="F9X0J2">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0J2"/>
    <dbReference type="GeneID" id="13398062"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67202"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="InParanoid" id="F9X0J2"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="446" mass="48175" checksum="B639CD19EEF35C0A" modified="2011-10-19" version="1">MPGPPSATWRRHLSRLLSKFDGANPRVLVAFWLFGLINNIFYVIILTAALDLVGPSVPKATVLLACIVPGLATKLVTPYFIHLVPYSLRVVIFVALSTCGMLAVAMSPSTTDAASISSKIAGIVLANISSGAGEINFLALTHYYGPFSLAAWGSGTGGAGLLGAGLYALATTTFGFSVHATLVASTILPIIMLGSYFVLLPLGPLRASRTEGEYLRVNEDEPGDTATGDSPEAAGLLGHPVTKSASHANRHPQQSWLSHRLADLNIKLLRARSLVVPYMLPLFLVYLAEYTINQGVAPTLLFPIAESPFEHFRAFYPTYGAIYQLGVFISRSSLPFIRIRSLYVPTLLQVLNLAGLTLHALWPFIPTVWFVFVIVFWEGLLGGLVYVSTFAAIREDIPEEDREFSLGAVSVSDSAGIFLAGLLGAGMETTLCSWQVHHGRNWCRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0L8</accession>
    <name>F9X0L8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="123" mass="14419" checksum="37DD50479C046F47" modified="2011-10-19" version="1" fragment="single">LPHYRHIPLENPAIQIRLLKATPTLRYNTDLVSHARAPRYNAISHTWGEPKNNTTIVVDERPLTVRQNCYDALLQAHRFDRHIYLWIDAICINQADDEEKSCQVHRMHDIYLWADHVLACLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
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    <name>F9X0P3_ZYMTI</name>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="primary">MgPP2Aregb1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_67389</name>
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    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="13398580"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67389"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="482" mass="54478" checksum="AC7A9285FF4806DC" modified="2011-10-19" version="1">MVEAGEGGTQPTWKFTQCFGDKGDVEDITEADIISTVEFDQTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSSELTPAGTGGANGGGPVRYPNTHNFRSTADLKFPRMTHHDTVVAAVPRRVYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPQSCNWFMYASSKGTIKLADMRQRALCDEHAKQFEQEEDPSSRSFFSEIISSISDVRFSYDGRYILSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSEEGKDTEVVLQADKSAFKAKKVGIPTPMNSATSPGSKDGKKGSRASSPAGGAQRMRKETDADQIDFNKKILHMSWHPQEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0U2</accession>
    <name>F9X0U2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Symplekin/Pta1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_10934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856712.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X0U2"/>
    <dbReference type="GeneID" id="13398553"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10934"/>
    <dbReference type="eggNOG" id="KOG1895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021804_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0U2"/>
    <dbReference type="OMA" id="AREMCLN"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="87"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="729" mass="81799" checksum="95272D5A23BD6944" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X187</accession>
    <name>F9X187_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_66670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X187"/>
    <dbReference type="FunCoup" id="F9X187">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X187"/>
    <dbReference type="GeneID" id="13395108"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66670"/>
    <dbReference type="eggNOG" id="KOG1967">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="InParanoid" id="F9X187"/>
    <dbReference type="OMA" id="IILDFTT"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
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    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="543"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="670"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="954" mass="105482" checksum="9483F8E0FFE4F7F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X200</accession>
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        <recommendedName>
            <fullName evidence="3">DUF7626 domain-containing protein</fullName>
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    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_90350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855810.1">
        <property type="nucleotide sequence ID" value="XM_003855762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X200"/>
    <dbReference type="GeneID" id="13395880"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90350"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.49"/>
    <dbReference type="eggNOG" id="ENOG502SRRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470267_0_0_1"/>
    <dbReference type="InParanoid" id="F9X200"/>
    <dbReference type="OMA" id="TANACKE"/>
    <dbReference type="OrthoDB" id="5321209at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056043">
        <property type="entry name" value="DUF7626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24625">
        <property type="entry name" value="DUF7626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7626" evidence="3">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="580" mass="65620" checksum="EF8A4CB6C8CB732A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X308</accession>
    <name>F9X308_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_99199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855451.1">
        <property type="nucleotide sequence ID" value="XM_003855403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X308"/>
    <dbReference type="GeneID" id="13399825"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99199"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.779"/>
    <dbReference type="eggNOG" id="ENOG502RXX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124166_1_0_1"/>
    <dbReference type="InParanoid" id="F9X308"/>
    <dbReference type="OMA" id="VWHHIKL"/>
    <dbReference type="OrthoDB" id="10255646at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16693" checksum="EB3C64627ED927DB" modified="2011-10-19" version="1">MSQAIPTSTSVVESAVIKAPLAAVWHYIKLEKFNTWYSAIKQSDYVKGASPDTDVVKWTFNDGTVLEVKQEEHSSISHYITYSIISSQPALSYSSVLSTIRCYPVTSGENEGSTFVEWTGNFSSDAGADVIQDAKFKRRDALADLAKASVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X339</accession>
    <name>F9X339_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_99210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855437.1">
        <property type="nucleotide sequence ID" value="XM_003855389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X339"/>
    <dbReference type="STRING" id="336722.F9X339"/>
    <dbReference type="GeneID" id="13399842"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99210"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624366_0_0_1"/>
    <dbReference type="InParanoid" id="F9X339"/>
    <dbReference type="OMA" id="RTAHNNR"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="454" mass="50103" checksum="49014A5BB216B838" modified="2011-10-19" version="1">MHAFRNTSLPFCTSACNTNTLVAVGDEEGSIRLIDSAQSARFQTSHVSFRVHRNAIMDLSFSSDDILLATASGDQTGRVVNMQTQQTTMCILSGHKNSVKQVRFRPNNDKMITTSARDGTVQLWDLRHGKQSAVQTVRVGRRQQIDADGRAQPDTRYGLGLDVGYGHRSLGRPFESDMRAELSITSFQHMPQGREHLLITSSEVDASVKVWDLRNVGKRNPIPLSSTPVPDAHKSSRHFGINTMALSGDGSRLYTVCRDSSIYAYSTNSLLLGHTPEMSLAGHRRLLKKPGQGLAPLYSFKHPSLRVGTFYIKAALRPAKDGRGEVLAVGNTDCKPILFPTDERHLPRGGRPLISHPEDDDDEESTPATTTTTSQDPNVFTQGTALVEAHKKEVTSVTWTNEGNLISISDDFTARCWREDAGRARDLRTGGERSGGRWRCGWAEAEKGWDEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X372</accession>
    <name>F9X372_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855334.1">
        <property type="nucleotide sequence ID" value="XM_003855286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X372"/>
    <dbReference type="STRING" id="336722.F9X372"/>
    <dbReference type="GeneID" id="13400730"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108288"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1025"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011174_0_0_1"/>
    <dbReference type="InParanoid" id="F9X372"/>
    <dbReference type="OMA" id="HAWSIRI"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="725"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112479" checksum="58B1B4E97A859539" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3M8</accession>
    <name>F9X3M8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_55315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854951.1">
        <property type="nucleotide sequence ID" value="XM_003854903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3M8"/>
    <dbReference type="FunCoup" id="F9X3M8">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3M8"/>
    <dbReference type="GeneID" id="13399591"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_55315"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3M8"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="132" mass="14596" checksum="B5BB2B4DF792A260" modified="2011-10-19" version="1" fragment="single">MPTLWLSDQQKFGVAFCTGGTAFLLLGLILLFDRSLLAMGNILFLIGITLLLGPYRTLAFFSRRQKWRGTLAFWTGVSLILLRWPLVGFLVQIYGMFILFGEFFKTLAGFVYGVPVVGPVLARVLSAAGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3X4</accession>
    <name>F9X3X4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HDA2404</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_37223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855078.1">
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="94"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="467"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="770"/>
            <end position="779"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="795" mass="89394" checksum="8E44EF4AC92C1962" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X410</accession>
    <name>F9X410_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_103459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855168.1">
        <property type="nucleotide sequence ID" value="XM_003855120.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103459"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1093"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_1_1"/>
    <dbReference type="InParanoid" id="F9X410"/>
    <dbReference type="OMA" id="ACLLCIK"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="172" mass="17862" checksum="F0563ED2167DD0ED" modified="2011-10-19" version="1">MSGLKDKILGKAGKALSQGSSLPATGPLKENDPHTGTVDLAKLQGKNIIVGVPGAFTPPCSSQVPGYVEKADAFKAKGVNGIYIVAVNDQFVVQAWKEKLGAKHENVHFLADDTGAFTEAAGMSFDASGLLGNNRSSRYVAVVESGKVTHVFKEDEAPSVTVTAADAVLGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4H5</accession>
    <name>F9X4H5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRMT2401</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_68512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854990.1">
        <property type="nucleotide sequence ID" value="XM_003854942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4H5"/>
    <dbReference type="FunCoup" id="F9X4H5">
        <property type="interactions" value="890"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4H5"/>
    <dbReference type="GeneID" id="13403437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68512"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.686"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="InParanoid" id="F9X4H5"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="345" mass="39058" checksum="B3AE28CE0783342B" modified="2011-10-19" version="1">MANASAPKGDDPMAGLVHSEAHYFNSYNHHGIHEEMLKDEVRTKSYRDSIYNNRHLFKDKVVLDVGCGTSILSMFAVKAGAKHVIGVDMSTIIYKAREIVAANGMSDKITLLQGKMEEVELPFPEVDIIISEWMGYFLLYESMLDTVLWARDRYLRKDGQGLIFPDKATIFMAGIEDGEYKDDKIGFWDNVYGFDYTPLKLTALTEPLVDTVELKAVVTDPCAILTLDLYTCTVADLAFSLPFQLSVRRTDYVHALVAWFDIEFSACHKPVRFSTGPHTKYTHWKQTVFYLADVLTVEAGEKIDGNLACRPNDRNRRDLDVGIDYKLLTEDSGRTADGHCEYKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4S0</accession>
    <name>F9X4S0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_22524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855277.1">
        <property type="nucleotide sequence ID" value="XM_003855229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4S0"/>
    <dbReference type="FunCoup" id="F9X4S0">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4S0"/>
    <dbReference type="GeneID" id="13400282"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22524"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="InParanoid" id="F9X4S0"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="310"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
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                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Schmutz J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854422.1">
        <property type="nucleotide sequence ID" value="XM_003854374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X537"/>
    <dbReference type="STRING" id="336722.F9X537"/>
    <dbReference type="GeneID" id="13395609"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38148"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011476_1_0_1"/>
    <dbReference type="InParanoid" id="F9X537"/>
    <dbReference type="OMA" id="FICQAND"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP89398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="251" mass="27470" checksum="9B7FAE50532880CD" modified="2011-10-19" version="1">MKVWIGVYLDGNQTTNDRQISKMYDLLDNYPHDSFAGIIVGNEVLYAKYLTATELGTQLESVRDNLTSKGISLPVATADLGDNWDATLAAQSDIVMANIHPFFAGTVAEDSASWAYTFWTGKDVPLKTQKTGSVGSITYPTQIIAEIGWPSQGGNDCGDATSPTYGCTSDTDGAVASIDNLNTFMDGWVCGALANGTTFFWFEAFDEPWKHQFDSSSNGWEPFWGIFDKDRNFKKGLTIPDCGGKTVDRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X582</accession>
    <name>F9X582_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854278.1">
        <property type="nucleotide sequence ID" value="XM_003854230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X582"/>
    <dbReference type="GeneID" id="13404345"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91982"/>
    <dbReference type="HOGENOM" id="CLU_1490158_0_0_1"/>
    <dbReference type="InParanoid" id="F9X582"/>
    <dbReference type="OrthoDB" id="3642993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="181" mass="19700" checksum="D4DAF3760B9FC221" modified="2011-10-19" version="1">MFPSYITSTVFLTSTSPINSSTSIPSTTLVPSTTLLPSSNPTPDPGPNAHVVDLTAADTYWPSESHSISYNVSSVYFQSNDGPFNISISWNFYNRVTPGSYKGANDFKLDVSSIGWYFDPILWNVTLDVAKGSTAGTSTPRPTLTESDEILCTLCNVKLVSMLDHGRNWSPALELVDDVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X596</accession>
    <name>F9X596_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854272.1">
        <property type="nucleotide sequence ID" value="XM_003854224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X596"/>
    <dbReference type="GeneID" id="13404352"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91995"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.870"/>
    <dbReference type="eggNOG" id="ENOG502R9G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1489891_0_0_1"/>
    <dbReference type="InParanoid" id="F9X596"/>
    <dbReference type="OMA" id="PSESHYI"/>
    <dbReference type="OrthoDB" id="3642993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395348" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="167" mass="18115" checksum="41EFD33CF2841B4E" modified="2011-10-19" version="1">MNRLTFATIVASLFATTTAQAPPFHIENFAAQDIRIPSESHNVSFTVKHLGAAPQQGGDAPFDLSIAWEGCDPPPCYINSEGTGWYTRIVPGSYKGATDFTLEIVKHNIYKAATTWTARIPYVEGSAGYDCSRGGQSTLCGFQDESDSTYETVYVGGLEAEYPSPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5H3</accession>
    <name>F9X5H3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853707.1">
        <property type="nucleotide sequence ID" value="XM_003853659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5H3"/>
    <dbReference type="GeneID" id="13404045"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91479"/>
    <dbReference type="eggNOG" id="ENOG502RH4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1469351_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5H3"/>
    <dbReference type="OMA" id="AGHEYRI"/>
    <dbReference type="OrthoDB" id="3632808at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="184" mass="20653" checksum="396DF430BE481C9F" modified="2011-10-19" version="1">MVQTDGKTEAEIKVTFSLTNTIYRRSAQLSEQPKMIVTTTLISPPTLAVELRGETDSGTILESGFRMEHFEFFDLTTSTMLKHSLFPGTCDPRESVGQWGVVELHSSKALVTSQQLEDMSPLADPIRDLKAGHEYRLRLKRIPGYAMSMAELFGEKQYVDVRNLPETVVVELKSDDEVILAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5R9</accession>
    <name>F9X5R9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_103760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-mannitol + NADP(+) = D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16767"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="5"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853870.1">
        <property type="nucleotide sequence ID" value="XM_003853822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5R9"/>
    <dbReference type="GeneID" id="13404209"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103760"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.597"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="F9X5R9"/>
    <dbReference type="OMA" id="GYRICIN"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="371" mass="39961" checksum="297BD0522BE3D6D0" modified="2011-10-19" version="1">MFKSSLLRQASRATSSAAVRQPSTAFITRTATRGLRTTPAVREKDDKSALDNLDEYSTAGKPGAFEHEGQFSRTDNTIRMEHPEEADMPSSAPVQGRGGFHFRRTLATFSLEGRVGVVTGGARGLGLVMSQALVISGADVAIVDLNKDEGQRQAELLMETFRKENPGSVNVPKVTAHYCDVSSPDSVNHAMAEILKDHGKVDHLVTSAGFTENFDAIEYPHDRMQKLWGVNVDGTYIWSCTVAKHLMERKASGSVVMIGSMSGAIVNVPQPQAPYNAAKAAVRHLASSLAVEWAHAGIRVNCISPGYMLTALTKKILDDNPELANKWTSLIPQGKMGRPEDLMGAVTFLLSDAAGYVTGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5U4</accession>
    <name>F9X5U4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854250.1">
        <property type="nucleotide sequence ID" value="XM_003854202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5U4"/>
    <dbReference type="GeneID" id="13395436"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92025"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.906"/>
    <dbReference type="HOGENOM" id="CLU_1361387_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5U4"/>
    <dbReference type="OrthoDB" id="10300976at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="201" mass="23095" checksum="DECC73AE1911DE72" modified="2011-10-19" version="1">MTPKPKPLRLWRKQKNGTFSPPGKAPATTKLTLPCDMLSPDKPWMERIQIIERPPYIPPIRPMPIVWELKHNNHSLRSSKSEEIAFRHLGTGPVSASDNTGDMKTLQQNHASNVLRQTPEWSAKKVLAARATSVFLEKQQWLWGKFDGSSCAAKRQALIVDITWACKEMDRRNQEFFDEVEVLEQTRIMEGMEEGEREICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6K6</accession>
    <name>F9X6K6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_69303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854617.1">
        <property type="nucleotide sequence ID" value="XM_003854569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6K6"/>
    <dbReference type="FunCoup" id="F9X6K6">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6K6"/>
    <dbReference type="GeneID" id="13404005"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69303"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.124"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6K6"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904902">
        <property type="term" value="P:ESCRT III complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="200" mass="21686" checksum="E5BA5068728915FD" modified="2011-10-19" version="1">MSGLEKALFNLKFTAKQLNRQAAKASKDETAEKAKLKKALAASHTDIAKIYAQNAIRKKNENLQLLTLASRIDAVASRVQTAVTMRQVTGSMGNVVKGMDQAMKSMDLEKISAVMDKFETQFEDLDVATGYYENATSSATATATPQEDVDRLMSQVADEAGVELSQEMAGATPAKGIQAPAAVEEEREDKLGERLRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6N1</accession>
    <name>F9X6N1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_69338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854601.1">
        <property type="nucleotide sequence ID" value="XM_003854553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6N1"/>
    <dbReference type="GeneID" id="13395787"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69338"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.156"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="InParanoid" id="F9X6N1"/>
    <dbReference type="OMA" id="WMHGAEG"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP89577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="606" mass="66734" checksum="948C7936D7419F5C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6N8</accession>
    <name>F9X6N8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_39612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854598.1">
        <property type="nucleotide sequence ID" value="XM_003854550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6N8"/>
    <dbReference type="FunCoup" id="F9X6N8">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6N8"/>
    <dbReference type="GeneID" id="13404017"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39612"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_2_1_1"/>
    <dbReference type="InParanoid" id="F9X6N8"/>
    <dbReference type="OMA" id="IPEHHLG"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="245"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="450"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="565" mass="62801" checksum="F3852FDF5451D1F6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7A2</accession>
    <name>F9X7A2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_37903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853941.1">
        <property type="nucleotide sequence ID" value="XM_003853893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7A2"/>
    <dbReference type="GeneID" id="13404280"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37903"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.736"/>
    <dbReference type="eggNOG" id="ENOG502SASY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089396_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7A2"/>
    <dbReference type="OMA" id="QWFDARE"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="25428" checksum="E6F2C1A57127BE7A" modified="2011-10-19" version="1">MDNPALQAILAQLSSYNQNASVFPPQPQQNESSMPNVQPQPQSNFAAPPPRAMIDPATITTWQEGLRCVTKIAAQNAQFAASIKRMIQNQREHETRWYTERQNLKRTQSNRAVSSAKVDSILASLGTSLTKSADRAPEVDKNAELLDFDQKIYAAQQAMEAGMTAELKGLGVPFFGVSEGLVVPDGAEVKRDEEGHDVPLKRSQCVTESEMMELRRRMVKHLEDLYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7N0</accession>
    <name>F9X7N0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_108472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853695.1">
        <property type="nucleotide sequence ID" value="XM_003853647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7N0"/>
    <dbReference type="FunCoup" id="F9X7N0">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7N0"/>
    <dbReference type="GeneID" id="13404034"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108472"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368501_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7N0"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferrochelatase_N"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="756" mass="84251" checksum="725E872E9934832B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X873</accession>
    <name>F9X873_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_70677</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853573.1">
        <property type="nucleotide sequence ID" value="XM_003853525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X873"/>
    <dbReference type="FunCoup" id="F9X873">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X873"/>
    <dbReference type="GeneID" id="13399559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70677"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.94"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="InParanoid" id="F9X873"/>
    <dbReference type="OMA" id="WHLPERH"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="167"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="418"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="545" mass="61926" checksum="EE6593870D232EBF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X881</accession>
    <name>F9X881_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_41363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP88544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41363"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078568_2_0_1"/>
    <dbReference type="InParanoid" id="F9X881"/>
    <dbReference type="OMA" id="SDWGNRT"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="185" mass="21136" checksum="BA72DF4551167C13" modified="2011-10-19" version="1">MGFFYQQSKPIQPLFHKPTWSFPTYDDQASIHLNSRTRKRHRDNRPDEESIYGASEGYDAITMSTINKLYDAQRQHPHASPVYSETDTMSSTSTVPAQRSTLHSFWRIPKAPATVPMALEVNERLVTDMEAFCEDCDKPLRHTDAMDIDQHFLEEDTSCKLCQRMICDTCAVLGDVRVCLPCASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8L7</accession>
    <name>F9X8L7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Structural maintenance of chromosome protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CPC2401</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_58445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853244.1">
        <property type="nucleotide sequence ID" value="XM_003853196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8L7"/>
    <dbReference type="FunCoup" id="F9X8L7">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8L7"/>
    <dbReference type="GeneID" id="13399500"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58445"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.765"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="F9X8L7"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="522"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="313"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="439"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="684"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="762"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131306" checksum="17F165301F241981" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8R1</accession>
    <name>F9X8R1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_40090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852848.1">
        <property type="nucleotide sequence ID" value="XM_003852800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8R1"/>
    <dbReference type="STRING" id="336722.F9X8R1"/>
    <dbReference type="GeneID" id="13400681"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40090"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.119"/>
    <dbReference type="eggNOG" id="ENOG502S39H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052383_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8R1"/>
    <dbReference type="OMA" id="GDMGYSG"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="41077" checksum="6F04BFB6CA41A667" modified="2011-10-19" version="1">MPRRQDVIARSVTRAIVHNDGPRTSSTSDRFTAFFKLYEMDFECIRADLFKELRNDVWQLEEKDYTASFGEEGKDGNSKLQAMEDMGFSGSTFFTTEDTAYIVKSVPRHFEHSFFKNDFLIPYVQHVHNNSGSLLIRTTEFLANKHFTIGQILQLAPTHHIAMENLLYQQGKNHWETYDLKPMSYFYPERDIAGGALTSEETKSKLADKFKDKLLLTLDQAEALKYQLEKDTSLLATCNAVDYSLFLVRIPITEAPNPFDDPQLNATPLLPPDPPSFRTGMPSTDGRWVYRAAVLDFFWAKHKAHAKAMSLLINAYNIFDRKGPMSVTTNSPEYRQRFLNMIYDMIEVRDDTTEQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9U5</accession>
    <name>F9X9U5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_41278</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853191.1">
        <property type="nucleotide sequence ID" value="XM_003853143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9U5"/>
    <dbReference type="FunCoup" id="F9X9U5">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9U5"/>
    <dbReference type="GeneID" id="13399561"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41278"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_0_1_1"/>
    <dbReference type="InParanoid" id="F9X9U5"/>
    <dbReference type="OMA" id="EGIKWRN"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="257"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="601"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="767"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="963" mass="107021" checksum="930160BE415977CA" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAG2</accession>
    <name>F9XAG2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852234.1">
        <property type="nucleotide sequence ID" value="XM_003852186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAG2"/>
    <dbReference type="GeneID" id="13396904"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93296"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529151_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAG2"/>
    <dbReference type="OrthoDB" id="3636481at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="57553" checksum="921E64663E80C6EE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAM0</accession>
    <name>F9XAM0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MgBGL12</name>
        <name evidence="24" type="ORF">MYCGRDRAFT_42620</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852046.1">
        <property type="nucleotide sequence ID" value="XM_003851998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAM0"/>
    <dbReference type="STRING" id="336722.F9XAM0"/>
    <dbReference type="GeneID" id="13393821"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42620"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="InParanoid" id="F9XAM0"/>
    <dbReference type="OMA" id="VVMESWI"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395573" description="Probable beta-glucosidase E" evidence="22">
        <location>
            <begin position="27"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="819"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGP87022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="922" mass="99887" checksum="EF90452619D6EFB2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAW1</accession>
    <name>F9XAW1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_42036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852724.1">
        <property type="nucleotide sequence ID" value="XM_003852676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAW1"/>
    <dbReference type="STRING" id="336722.F9XAW1"/>
    <dbReference type="GeneID" id="13397047"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42036"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="InParanoid" id="F9XAW1"/>
    <dbReference type="OMA" id="KWIAAGP"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="311" mass="33949" checksum="3236F7B0F1C38FB2" modified="2011-10-19" version="1">MTSPRPSNDIEDFHALLSRSKRVLSLLGAGLSASSGLPTFRGAGGLWRSHDSMSLATPQAFAADPALVWRFYSYRRHMALTVRPNPAHYALAALARKLPGFVTLSQNVDGLSPRAEHPKDQLKLLHGSLFEVKCNDSRCGYVEENYTDPIVPALDLPDGKDITSDEYRTMGGKVDISDPQVQLAQISREDLPTCPQCRRALLRPGVVWFGEALPDDVVDSVYAYLDEPEKVDLIMVIGTGAKVYPAAGYIEEAREKGAKVCVVNMDANDAPPGGWAEGDFFFQGDAATIVPELLRPIIGEVKVPEQEKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAW5</accession>
    <name>F9XAW5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_109391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852091.1">
        <property type="nucleotide sequence ID" value="XM_003852043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAW5"/>
    <dbReference type="FunCoup" id="F9XAW5">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAW5"/>
    <dbReference type="GeneID" id="13397044"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109391"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.166"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="InParanoid" id="F9XAW5"/>
    <dbReference type="OMA" id="RGRSDWC"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="81"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="453"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57049" checksum="04E3F0B92FCC8440" modified="2011-10-19" version="1">MRWILRSRSKSDRLLWLTLSTITCILAILLYRSPDATALRLRASDRKAVQWNIKHHLGGISPWYARTPQGINGSHDVPPGCVVDQVHLMSRHAERFPTLAPGIRMLELYQRLQHANITFTGDLAFVNTWNFLAPLPDQQFEQLTTTGPYAGTLSAFSAGVKLRTKYFHLLESAIARRQTSFWASDSQRVIDTAKHFASGFFGMDWADYTTLHIIPETLEQGSNTLTPGRACQNYFDDTDDYGRGYGAKQLKAFGETYLPAISQRLLNGNPEIAFSNEEVYTMQEMCGFELMAKGSSQWCDVFTHEEWLSFEYARDIWHYYRAGSGNPYAAPLGLPWLNATTKLLRQGPEAGPLFFSFNHDGDIMTLLAALDLLPQDPPLPTTHVLHDRTWRMSDVTPMHGRIALERMTCTALKTCFANPLYPNHVYCDENEEEEYQTYVRIDVNDAIVPLPGCADGPGGSCPLHNFEKRVEKSGRETKSFAEMCGTGASGGVEFLHQEQKQAFPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB07</accession>
    <name>F9XB07_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="318" mass="36400" checksum="53C3A34B9ABC87C1" modified="2011-10-19" version="1">MALEKPAHQGIFSLPNEILLNIFGLFRTDKLVVFARTCRHFHSLILRLLHSRMQAATALDGHTLYLECYPPFAKWTTSKLFCAYLGTDGLQELTDELQQSGGRTGHSKRMGELFCRFRPSNKEPDWTNIRRPHPAGDIPGTRTYMSQDQMAAETAKLLDRQTAVTTTITVDAHDLFSQLCTDVCDGTIRVWRDWLSRQCETKRWTDGEAIIVHHDNRESRGAAQATAGYIDPRKDPSILWINTVREQVGIKFRVKEQTWRREPPVAFGSEAEMPVSYRVEMEEVLVRTSHLLLKMEEAREQSLNYGGKAIIFGSYIQE</sequence>
</entry>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="90" mass="9536" checksum="1EF3D7435C27EC0B" modified="2011-10-19" version="1">MDFIKKAAGSLGNKEGQQQDGQPAQQQGGQPAAGGAPAGQKQDYGDKAFDTISKKAGHDFTPEQDEKITDGLRGAYEKFSGSKVNDKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC15</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="15422" checksum="F45E0A58B1E7E974" modified="2011-10-19" version="1" fragment="single">KTCAFFLDKRFFFLHRTSITDIDRSTPNLTNLTKPPLNPQNQPQEPQENPKKLKKASSNLRRQKGRAHLRQSRATQIQLTKAEDTHPQETLKTTPPKRQQLRKPAPKHTCDTHQAHESSRHSQQNLRITFVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC72</accession>
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        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC72"/>
    <dbReference type="STRING" id="336722.F9XC72"/>
    <dbReference type="GeneID" id="13396965"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86077"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.348"/>
    <dbReference type="eggNOG" id="ENOG502S0RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_4_3_1"/>
    <dbReference type="InParanoid" id="F9XC72"/>
    <dbReference type="OMA" id="FGTHKIN"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="15018" checksum="EAE7C9D1F7681760" modified="2011-10-19" version="1">MASFAVKSIDHVVLTCRNIPATINFYTQRLGMRHEVFTSKGVERHALLFGNQKLNLHQSGKEFEPKAGTVQPGSEDLCFVTEHPIEEVQKSWKDNGLEILEGGEIVDRTGAVGKLKSVYCRDPDGNLIEVSNYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD53</accession>
    <name>F9XD53_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851447.1">
        <property type="nucleotide sequence ID" value="XM_003851399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD53"/>
    <dbReference type="GeneID" id="13393651"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43083"/>
    <dbReference type="eggNOG" id="ENOG502SUXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002757_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD53"/>
    <dbReference type="OMA" id="CRNWAEF"/>
    <dbReference type="OrthoDB" id="3650471at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="861" mass="99624" checksum="D4B8B340500EBC70" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA1</accession>
    <name>F9XDA1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_100492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851479.1">
        <property type="nucleotide sequence ID" value="XM_003851431.1"/>
    </dbReference>
    <dbReference type="SMR" id="F9XDA1"/>
    <dbReference type="FunCoup" id="F9XDA1">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDA1"/>
    <dbReference type="GeneID" id="13401538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100492"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000684_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDA1"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1286"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="493"/>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="2074" mass="235109" checksum="8CB979EB659D0E65" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86335.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Bristow J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="575"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850984.1">
        <property type="nucleotide sequence ID" value="XM_003850936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEY0"/>
    <dbReference type="GeneID" id="13397724"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94762"/>
    <dbReference type="HOGENOM" id="CLU_664318_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEY0"/>
    <dbReference type="OrthoDB" id="10455463at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="414" mass="45674" checksum="3E7D4D7DEEA482F5" modified="2011-10-19" version="1">MGCNTSVAAGKRGKDKSRYAGGHASCGISVHRGVVVSMGYGNYTAIITAVGAWRSVRTLSTLRIHLHACHFEDLHFYDLRETVMASARECEADDDGNSLPSNRIKAFTEECTGRTLRRPGKVGTIIMTTTPMSAVWQSIPLEITTMILVETALLPLKVHAHSYLHHRYISALETTNPPSTNAWQVVLSALAINHSTRRAVIHALNTNGAIEHKTDPGVAYTAHFGPQPSWALLAHFRWVFVSVEDRMDRDDVRCLCGCRCPGRAGDRTKEQRGQSMGSVAGGESEAQRDELQVLELKRITKVKGTIATLQRICFEFEYANTTPLITGPKSTAQTPSEDGNASPSHSTKSRPEAAPFVHAIPRNPPTCDFYDWRNLIPSGDKVSDGEEDDSEEDDSEKDDSEEDDLEESEFWEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF12</accession>
    <name>F9XF12_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_94330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851242.1">
        <property type="nucleotide sequence ID" value="XM_003851194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF12"/>
    <dbReference type="GeneID" id="13395355"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94330"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.163"/>
    <dbReference type="eggNOG" id="ENOG502RHDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154787_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF12"/>
    <dbReference type="OMA" id="QLHEMCA"/>
    <dbReference type="OrthoDB" id="3635516at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391351" evidence="2">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="131" mass="14902" checksum="2860E3C05669827B" modified="2011-10-19" version="1">MQLTPLITTLLLLTFTTLPILADDYQDAVACARKDPASNSAIQTFCFKRNAQGITDNIHVPSPYASKGRRSTNGKTRASIKGTCDPPQWVPITYCNSQFHQMCARSPRRNGWDRRNFGRKGCQEWRLERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF67</accession>
    <name>F9XF67_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850969.1">
        <property type="nucleotide sequence ID" value="XM_003850921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF67"/>
    <dbReference type="GeneID" id="13397635"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94794"/>
    <dbReference type="HOGENOM" id="CLU_696781_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF67"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="396" mass="45462" checksum="5A013E43EE7AFC5E" modified="2011-10-19" version="1">MLYRRDRITFRGLKFEVSGVFVGRVGSYSLTFCNIPYQPRLTISSKIDFPSTLHIHFSDPAAPAVPNNPVTNSILKKFKHLTISLRIAMQSSERHPMARRPAAMGNLTMHYTYTAGKWSLSRDDTTWTSDLVHEQFPLRWMQNLAQDIDIRVCRDLRSERLTSKNGTEVLPQIAATNAEEWSTMRTMQGLNPVMEYLAGYRHGFSFGSEMVIRFVNKTSMPAVRYIHDGPTTDPRNIIPFTMLERFTHIKLEIPISLIKFNGQVIGGIINTKFWTDGRGLVWWAELGQSWWEPVSPGADSEEARSLARENMLMLEHYLLQNTLSGSNHQVSLQQMRLAVGSFINLMNARTDPILYLRHGWTFERLDAGIHRHDRSNARRELLKEVFSGYPQASVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFE3</accession>
    <name>F9XFE3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_110145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851201.1">
        <property type="nucleotide sequence ID" value="XM_003851153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFE3"/>
    <dbReference type="GeneID" id="13397941"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110145"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.246"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFE3"/>
    <dbReference type="OMA" id="HTSNPGF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390485" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="498" mass="54296" checksum="A06453944CD21702" modified="2011-10-19" version="1">MHLLRLGATIGGLALVSAEPGNPFKHLGSDLLHAVEKKFNTSSLDACTELLKLKKESSKSDVVFLPFTTDNAHYLLSSSHASACVYTPHTAQDLAGAIKIIAKHRTPFAVECSGHASNPGFSSTAGIHISMHGFQDVTVSGDNSYVDIGGGISWADVFEKLDSSTVNVLGGRVPGPGIGGFLTGGGGYSWLTNQYGLTGDTLISASIVLPDGTITEASETSSSDLFWAIKGGGNQFGVIYNFRLKAFPRPPQIYGGLKFFAGPPSQEVLDAIADFSNNVKDPKASIIPTVNWVLGVPFTTVLAYYDGIPEGDPFSMFNATSNYKKQSFNEFIKSQSISRLAGNQRGAFNTASLQKITPNVLAQVKNQSEFWSRKAPAHAGTFLSIDVEPFEPYSQYAKDAAWRHEKNELPLYLFFGWQNPLEDDFWRAALLESCEMIANAARQEGQQIDDMLLYPNYALNEIPSERLFGAENLARLRELKGKWDPNNVMGLTKYFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG25</accession>
    <name>F9XG25_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_94554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851097.1">
        <property type="nucleotide sequence ID" value="XM_003851049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG25"/>
    <dbReference type="STRING" id="336722.F9XG25"/>
    <dbReference type="GeneID" id="13397481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94554"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000702_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG25"/>
    <dbReference type="OMA" id="WILNTDD"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391382" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="929"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1135" mass="119726" checksum="5A23837E443A49D2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG57</accession>
    <name>F9XG57_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_74162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850759.1">
        <property type="nucleotide sequence ID" value="XM_003850711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG57"/>
    <dbReference type="GeneID" id="13397821"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74162"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_4_0_1"/>
    <dbReference type="InParanoid" id="F9XG57"/>
    <dbReference type="OMA" id="WRATFDT"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="50"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="319" mass="35875" checksum="031D0BC6DD29902A" modified="2011-10-19" version="1">MSTPRIHDRAQAGFANSTAYDSHRPAYSDTITQVLLEQLDVEGKQGAVIVDLAAGTGKFTEALAKREEGFRIIAVEPHQDMRKVLEGKQLKGVSVVDGVADSMSSLEDESVDALTIAQVGLQCWYRANCSQSFHWFANMDSLKEFHRVLQPHGRLGLVWNVEDWNAPKNHKASTAWEKVAHELNFAIAEESGDDQPRFRHQEWRKVFDEQIKVTPLTILKASDDQLFSLPIGEHVEPFEVALPVEDAWKRFRTLGQISVIEGERLEVCRSTFMDAINGEDVEKNENGDVIIHGNSYAYWTSKIPAEGRDGVFSVEHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG92</accession>
    <name>F9XG92_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-Fructofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MgSUC3</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_74191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP86048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG92"/>
    <dbReference type="FunCoup" id="F9XG92">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG92"/>
    <dbReference type="GeneID" id="13397511"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74191"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_3_3_1"/>
    <dbReference type="InParanoid" id="F9XG92"/>
    <dbReference type="OMA" id="GTEWRHA"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390533" evidence="5">
        <location>
            <begin position="22"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="402"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="564" mass="61609" checksum="6CE2F48041296A99" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGB6</accession>
    <name>F9XGB6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_110270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850785.1">
        <property type="nucleotide sequence ID" value="XM_003850737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGB6"/>
    <dbReference type="GeneID" id="13397800"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110270"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.532"/>
    <dbReference type="eggNOG" id="KOG0255">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="InParanoid" id="F9XGB6"/>
    <dbReference type="OMA" id="THFSEDP"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="595" mass="65703" checksum="03D5713AF4345B7C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGL6</accession>
    <name>F9XGL6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_18024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGL6"/>
    <dbReference type="GeneID" id="13397777"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18024"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_1_0_1"/>
    <dbReference type="InParanoid" id="F9XGL6"/>
    <dbReference type="OMA" id="MQNTVDH"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PXL2A/B/C"/>
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    <dbReference type="PANTHER" id="PTHR28630">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="214" mass="23974" checksum="1F242BE6CD4FE20A" modified="2011-10-19" version="1" fragment="single">SDPCPDRAALAAVQNIPIYSADGTAHPFGSIYDPALAQHTRQLVLFVRHFYCGACQAFLQAMTASISNADYFAIPVPTSIIVIGCGAPELIPHYKRFTGCPWPIYADPTRALFKKLGMSISMNLGLERPEYMKDISSAQWGAGQIRQIREELKNPEGMRADGLRKRDILLKGGHPMQIGGEFLFEEGNVVWCHRMRNYRGHTEIKVIRKLLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHZ5</accession>
    <name>F9XHZ5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850062.1">
        <property type="nucleotide sequence ID" value="XM_003850014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHZ5"/>
    <dbReference type="GeneID" id="13394263"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95217"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.433"/>
    <dbReference type="HOGENOM" id="CLU_894900_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHZ5"/>
    <dbReference type="OrthoDB" id="10466564at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="311" mass="35493" checksum="310A0566AD9C0782" modified="2011-10-19" version="1">MPRTARGPRHRFLNDHHQDLQQVRIGSAGISRSHEDEYDEHNDDDNAGRGGYNDGFQQHDDWEDYDDRKDGWEDITKQHCSNISTPAYFHPPQLQPSPRAGLVSFYYSLPPGSTFSHHQLAPARLPTLPRLQSLESHSTSMPPYTQHTRNHHHRACTCGCQARAPCRAAPWHNTPNHHHVAMRSPPLEQHNSPVDSLAEPVSPEPRRPEAWMPFSGDLGDSGDGGYGDDDEDIEMDLDVSVVDLDVEEFVEGNGWNWGNDWIWVFDEHEIDEMDGEMSEADSLGYTGDESSDEGYDGDDEREWDEWWKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIC2</accession>
    <name>F9XIC2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">G6PD</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_100879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
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        <property type="protein sequence ID" value="EGP85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850503.1">
        <property type="nucleotide sequence ID" value="XM_003850455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIC2"/>
    <dbReference type="FunCoup" id="F9XIC2">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XIC2"/>
    <dbReference type="GeneID" id="13395156"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100879"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.102"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_013524_2_3_1"/>
    <dbReference type="InParanoid" id="F9XIC2"/>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="209"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="509" mass="58325" checksum="AC116CD931027684" modified="2011-10-19" version="1">MADNIISNSRDSEEQSNAGTMELKENTVVIVLGASGDLAKKKTFPALFGLFRNGFLPKDVKVVGYARTKMDHEEFLKRVKSHIKTPTKEMEQQLAEFVKFTTYVSGQYDKDDSFQELEKHLGELEKDQKHNNRVFYMALPPSVFIPVSEHLKKNNYPKNGIARIIIEKPFGKDLESSRGLDKALRPNWKEEEIFRIDHYLGKEMVKNILILRFGNEFFGATWNRNHIDNVQITFKEPFGTEGRGGYFDEFGIVRDVMQNHLLQILTLLAMERPISFSAEDIRNEKVRVLRGMPSIEPKDVIIGQYEKSLDGSKPGYKEDDTVPKGSRCPTFASMVAYIKNERWDGVPFILKAGKALNEQKTEVRIQFKDVTSGIFKDIPRNELVIRVQPNESIYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDSLKGDHSNFVRDDELDASWRIFTPLLHYLDENKDITPMGYPYGSRGPAVLDDFTSSYGYKFSDAAGVTHEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIE4</accession>
    <name>F9XIE4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_94966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850492.1">
        <property type="nucleotide sequence ID" value="XM_003850444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIE4"/>
    <dbReference type="STRING" id="336722.F9XIE4"/>
    <dbReference type="GeneID" id="13395145"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94966"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.128"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIE4"/>
    <dbReference type="OMA" id="YKLMGED"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="31521" checksum="D62CC33E8BF7C013" modified="2011-10-19" version="1">MSTFNLTSPSKPTTTPHSRPSTSSSDDIDTLPYPAPLSRSDFLSPTFDPATYLSTLRNRHQTLEDLRSDLRSRSQLLNRELLDLVNDNYEHFLGLGDDLKGGEEKVEGVRVGVLGFRREVEGVRTGVRERAEEVKGLVEEKKRLRREAMLGRGLLEVGERVGELERRLGVGGGMEDEDDVGDEDEEEEDEEDVEGVPVKKLRRHADSYLIIRLLMEKLGPEHPFLVAQKSRLVDIRRTMLLDLAAATRKAKSVKASDAMLALVQIYADLEAQAEGIKVLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ31</accession>
    <name>F9XJ31_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849813.1">
        <property type="nucleotide sequence ID" value="XM_003849765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ31"/>
    <dbReference type="GeneID" id="13398924"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105657"/>
    <dbReference type="HOGENOM" id="CLU_2456512_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ31"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="89" mass="9981" checksum="0018419F35AF8FF9" modified="2011-10-19" version="1">MAFKLNSHHAEHKCLCLSNTPSIPRSSPAKCFSTEDINHNHYLLDAVPRDTEDQSTLSTLPVSIQNSRLTYHDPAGQSSRTPQIQHRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ59</accession>
    <name>F9XJ59_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849799.1">
        <property type="nucleotide sequence ID" value="XM_003849751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ59"/>
    <dbReference type="GeneID" id="13398938"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95586"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.133"/>
    <dbReference type="HOGENOM" id="CLU_542069_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ59"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56183" checksum="E59C9997F92B175E" modified="2011-10-19" version="1">MAADKSDGSSRSAFLALCLTCKTLLRATRPLLYAEVHLDRPTAEGCALTSTRQLARTLCAAPHLGLLIRKITSSPLLESWDQLYDVRDAVHGERDSADLLQFEKVLTSKLHSEADVASLAKAFATGFDEILGFRPDVLVVLMMSTQVESVAIHQVGVYWNSGREEMAVGVPLVMFWARKNLLHLPSDAFSHLTELKIDGLQLCEDYASVPMCKFMSPEGSLRAVPAVMGLSSLQRLEVSGVSWNMSHDKWPLAKGSSSIKSLDLLDCNLNSRTITALIETCSVLHEFSYAARSPRIQMERIGQGPFDYQVGTLALHAALSPHKATLRDLTIINLEDEGRLWDANDEFSLSGFHSLTSLEIDLQLLVGNQGQTNISTAVRSLPSTLRKLVIHVYSVSFPLEIFINELKTLQHRGLDRFEATLPPKDNWGGSTSDRQFFEIVYDHNSRYDPAFERYPVVLNVGDYRSCHRVIFRCRGLQQWSEEEVEALADAFRRRDVSSMEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJA7</accession>
    <name>F9XJA7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_75683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849443.1">
        <property type="nucleotide sequence ID" value="XM_003849395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJA7"/>
    <dbReference type="GeneID" id="13402238"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75683"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.401"/>
    <dbReference type="eggNOG" id="ENOG502S8NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XJA7"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395645" evidence="1">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="288" mass="30125" checksum="600E64519DA2024E" modified="2011-10-19" version="1">MRISATLSIVALCHLATARISGIAAPFVIAPDSAFNVTILTENYIQSVKDISASFALSSTAADGFLGVEYLGSFYLGPKNSNILTNITLEVTAPSTTNAKFLTAAITSLYGASNGPVTEQFSVPITFGDETSEETTVSRDRSNICSTAASPASSSASAIGPRATPSCTFPTMTNTLIQLSLVGAEGLINNIIQNDNRTGTQNLGELNGVLGDVTRAVLPSGHCNNEPTGPWPPLSPADSQARAVQILRDTEGGLNALQGAVLECEKATAVSVLCRVLHLMDYLDTYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJD6</accession>
    <name>F9XJD6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849651.1">
        <property type="nucleotide sequence ID" value="XM_003849603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJD6"/>
    <dbReference type="GeneID" id="13402257"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95836"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.432"/>
    <dbReference type="eggNOG" id="ENOG502SRG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337420_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJD6"/>
    <dbReference type="OMA" id="PERPSMF"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="893" mass="97080" checksum="15E7C8B3129C4527" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJG4</accession>
    <name>F9XJG4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_18277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849342.1">
        <property type="nucleotide sequence ID" value="XM_003849294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJG4"/>
    <dbReference type="GeneID" id="13402570"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18277"/>
    <dbReference type="eggNOG" id="ENOG502SDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071085_2_0_1"/>
    <dbReference type="InParanoid" id="F9XJG4"/>
    <dbReference type="OMA" id="DTHLIVC"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="188" mass="20680" checksum="D0CBEF65CFCAE2F7" modified="2011-10-19" version="1" fragment="single">STPVVLQVESAHDFVQYILDKHAPPTTLVVCSSKADFITALQSTELESSVWQVSTLRMLSTSRTVKLAFCPDITHLRAYLASRSTDNSTSTDTGLRQSNAMPMLALLDPIQLHRPTSAFSAQGLNRSFAIAVEAARHLGVKLVMAETDATAWDEELSMLNVTTKRLGELSVGRTVKVRVVAERWCTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJV5</accession>
    <name>F9XJV5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Mg61467</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_75289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849835.1">
        <property type="nucleotide sequence ID" value="XM_003849787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJV5"/>
    <dbReference type="FunCoup" id="F9XJV5">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJV5"/>
    <dbReference type="GeneID" id="13398887"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75289"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.53"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJV5"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PHI-base" id="PHI:2441"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="305"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="478" mass="53221" checksum="AF2D9AC2C264CBE4" modified="2011-10-19" version="1">MATRRNIVFVHPDLGIGGAERLIIDAAVGLQSNGHKITILTSYRDTNHCFEEARDGTLDVRVRGDAIFPPSLFGRFAILCTILRQLSLVASTVPRELPTLVPDVIIVDQLSACIPFFRLLYPKAKVLFYGHYPDRLLVQQEVGSLRKVLKKLYRLPFDAFEGWSTGCADGVVVNSKYTRSVFRQTFPDMKKRELKVVYPCVDTSEDEGATRDNSAPLLPNRKILLSINRFERKKNLALAINAYAGLAPSERSQSTLILAGGFDPRNAENALTHTNLQSLADSLRLTHATLRSPSISTLTTSPETDQQANILFLLSIPSSLKSTLLQQAKILIYTPSNEHFGIVPLEAMLSRTPVLATNTGGPLETIYDGRTGWLRSPEKVDAWTDVLRKGLISSSEESLRKMGEMGRERVLKEFSREKMTRELEGEVERLIQMPGRLRPGVMPEWMIIPFVGLLVLGMLVLLALVMMVLGMGVNRIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK21</accession>
    <name>F9XK21_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_87601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849503.1">
        <property type="nucleotide sequence ID" value="XM_003849455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK21"/>
    <dbReference type="STRING" id="336722.F9XK21"/>
    <dbReference type="GeneID" id="13402411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87601"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.510"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK21"/>
    <dbReference type="OMA" id="YDATIDH"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="225" mass="24994" checksum="E238356EBC274F5C" modified="2011-10-19" version="1">MASLRSAATSALRTSSVRPTISLRTPVLARYQSDGSAKPRAQSASGELARPPSGSMGHAVVRRENPPHGQGKHQPDYNVAVDYRTSNFSPVPMRVMDGSEPGDDTPAAVLSGAPIELQARTVRIYKPSKTATQSGDWHGHQWRMDWDPLSKGHRWENPLMGWQSSADFMQGTHLNFDTKDAAVAFAKKQGYEFFVQEPNERRIIPKAYADQFVHSPKKLKQVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK22</accession>
    <name>F9XK22_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849614.1">
        <property type="nucleotide sequence ID" value="XM_003849566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK22"/>
    <dbReference type="GeneID" id="13402299"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95907"/>
    <dbReference type="HOGENOM" id="CLU_1807739_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK22"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="16367" checksum="1AE6AA4A6F3ED949" modified="2011-10-19" version="1">MALTYTPKTSFLDLSAELQNFGLKRLSMVREIRREEFGSDKCLHQSKKHLQQIMRKLKKHNNPLRQDAVRVKLLVSVPPKLGSLISEPTAMWISSAEIDDLRQDVQGAENVAWCDANIVHRCHGPIFWKDHEPMGPTVFLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK56</accession>
    <name>F9XK56_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_110875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849598.1">
        <property type="nucleotide sequence ID" value="XM_003849550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK56"/>
    <dbReference type="FunCoup" id="F9XK56">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK56"/>
    <dbReference type="GeneID" id="13402317"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110875"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.547"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK56"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="238" mass="25578" checksum="E4F7977EB5EDA201" modified="2011-10-19" version="1">MSVQPKDTTDAKEFGSKTMTPEVTWAQRSSKTEAEKNHIFLTIAVVDVDPKKIKLDIQPTSLTFTGYSESKKADYAVKLEFYAEIDPSASKINHSPRAVELVLQKKELAEEYWPRLLKDSKKVHFLKTDFDRWVDEDEQDAVGEEDDYMSKMGGMPGGMGGGMPGMGGMGGMGGDGGFGGIDFSKLGGMGGMGGMDMSGMGGDDDEGDDDDDEDMPELEGDASAAAAGGSDKKIEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKA3</accession>
    <name>F9XKA3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_75577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849700.1">
        <property type="nucleotide sequence ID" value="XM_003849652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKA3"/>
    <dbReference type="GeneID" id="13402497"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75577"/>
    <dbReference type="eggNOG" id="ENOG502RP4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019366_3_0_1"/>
    <dbReference type="InParanoid" id="F9XKA3"/>
    <dbReference type="OMA" id="YACSKVY"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="500" mass="56076" checksum="0CD989A47198015F" modified="2011-10-19" version="1">MVTTNTMSSLLEISHELLHIIFAETSPADLAALSASCRTLHSYVRSNRLLHKDLYVRFYDEPRQRLTPTFSTAATSSTPTNSAAEASSSCESTPREKEPDWEEELHKLVRMDKILNSTDIAAKRENLGFVAEQIEHLVQTASTTDPESSQNLALLRRVFQNDANIDTFLCSSSLFARAGNDQQQPAETEEMRQASAKLHCYYGVPIDSTRSAVLKPRLTHPFARSKVYDLREYTLQTLWGPFRADGSGRVDWEKVEAIMIVLGYNLNKFAGRSEGRFQVAWNQPFDGATAGSFRSPPKEPELKRVRELALGLDAQDPFGVSGSWMRVVCFLDYNDLYSFNFTERIPEGQARDGIETEEAIRLIRIKLQVTRIDPPGSDGLDWSNFTGTRLPVVHFRGTSRSLHASWDPNANSRIRGTVRQTPEGEIRWTTFSIFHGEERWRSEGIQVGGRGSKRGVLGNWFDKDYDMHGPAGPTAFWKESDEVGEEKGAAGAAGGPLSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKG5</accession>
    <name>F9XKG5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_95977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849565.1">
        <property type="nucleotide sequence ID" value="XM_003849517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKG5"/>
    <dbReference type="FunCoup" id="F9XKG5">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKG5"/>
    <dbReference type="GeneID" id="13402339"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95977"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.606"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKG5"/>
    <dbReference type="OMA" id="MSMRIVP"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17062" checksum="C2CBA0B55DE56886" modified="2011-10-19" version="1">MSLRIVPSTAHSTLTSPSLGAPSAPGVHDTLRSNLALSTPAPKSTTFSSADISSAHPLESRLANWRAQQEGLKMSLLRRQFGIAEPVKRQMELSIVRAGEWRPAMLQGGGTAGLHADILSGRDTEMGWEDVFTGEEMREMPDFHTEMEGRFRMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKR0</accession>
    <name>F9XKR0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_48794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848812.1"/>
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    <dbReference type="AlphaFoldDB" id="F9XKR0"/>
    <dbReference type="STRING" id="336722.F9XKR0"/>
    <dbReference type="GeneID" id="13398611"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48794"/>
    <dbReference type="eggNOG" id="KOG0954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0958">
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    </dbReference>
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    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
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        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="338"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="584"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83836.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="956" mass="107736" checksum="7349B63B71696979" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL15</accession>
    <name>F9XL15_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_76066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003849166.1"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
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    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="47022" checksum="BC667FF9934166DF" modified="2011-10-19" version="1">MAEGRDKIVIVGTGWAGFVLSQELNDSKFDIFVISPEETRPYTPLLASAACGIFDFSVAEEPVRRQSRRITFYKARVESVDFDGKTCACRSECDVQDGDSRRFDVSYDRLILAPGCVTNTFGTPGAEEHCFFLKNVANARKVQYRLKQMLELASVPGITDQEQRELLHIIVVGGGPTGVEISAEISDLYNHDFRLLYPHLAGKMTIAIHDAAPSILGDFEKALQKHSIESFSQRNVQTFTDSKIQKVERDSITTEGEGRIGCGMVLWTAGNKQCALVDELDVSKTDKLPRIMTDEYLHVLDRDKKPMRDVYALGDAADIKKYFLPTTAEVAVQKAQYLVHALNRDTDGQKPFVYGEKSIIAYIGGQDGVVQGNSEWTGSRAWAAWRGKNLSWTRNWRRKLIIMVYWVLNYTGGKEIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL85</accession>
    <name>F9XL85_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_96080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849205.1">
        <property type="nucleotide sequence ID" value="XM_003849157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL85"/>
    <dbReference type="STRING" id="336722.F9XL85"/>
    <dbReference type="GeneID" id="13396617"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96080"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.101"/>
    <dbReference type="eggNOG" id="ENOG502RNWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161940_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL85"/>
    <dbReference type="OrthoDB" id="3650892at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="239" mass="27129" checksum="4D1384450C9E7142" modified="2011-10-19" version="1">MAFTRSTLGQLASSSTAHAIIGALAAMFLPKLPFFFVLQFLGVYELVSRLSSEIPALPSIRAYLDTLPSPFRIFKPEECIHCKDSFEDPVVLSCGHVYCRECIYSWIAFGKNYCPLCSRVVYSYRLRDEHRVPTLTKIYVCVSVSNLTASLMFPVLLVTHQSWKGFGFWDLVYCGVMQTLNLLVTMYELAIFWKLWHSHGSGWWRHPSLLTGHAAPILVGVRGFSVLLLIGQLQYELLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLY6</accession>
    <name>F9XLY6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849034.1">
        <property type="nucleotide sequence ID" value="XM_003848986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLY6"/>
    <dbReference type="GeneID" id="13398431"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106023"/>
    <dbReference type="HOGENOM" id="CLU_1387265_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLY6"/>
    <dbReference type="OrthoDB" id="10607764at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="197" mass="21652" checksum="230694384F338B65" modified="2011-10-19" version="1" fragment="single">MDALKRHFRQVHRTELTFPCFFDGCPESFTRRDMAARHLATHDSTAYMTCIGCRGKFRLGYFLREHLQARCCGNYNTNFRAEMDASNPQPIPSPEVARDATDVFANETSHLASGSLQWEMQATGVESQLGPEADDGSTIFWAERAARAGSQSYSPTPGETGHSTGFRGNAVEPKFSSQDENALSAAVVESGHHSEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM60</accession>
    <name>F9XM60_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_82700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848530.1">
        <property type="nucleotide sequence ID" value="XM_003848482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM60"/>
    <dbReference type="FunCoup" id="F9XM60">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XM60"/>
    <dbReference type="GeneID" id="13396234"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82700"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="F9XM60"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="480" mass="52732" checksum="BF5A9B2F09C54AC3" modified="2011-10-19" version="1" fragment="single">MATNGDTSHLALPQAHQDLMQNSLVDTDPEIAELMKKEIKRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNEHIDEIELTCQARALKTFRLDPAKWGVNVQSLSGSPANLQVYQAIMRPHDRLMGLDLPHGGHLSHGYQTPTKKISAVSTYFETFPYRVNLETGLIDYDQLEQNALMYRPKVLVAGTSAYCREIDYKRMKEIADKVGCYLMMDMAHISGLVAAGVNKSPFEYADIVTTTTHKSLRGPRGAMIFFRKGVRSTAMKAGKEVQVLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFLQYQQQVIKNAKQLEHSFKSLGYRLVTDGTDNHMVLLDLKPLGLDGARVESVLDQVNIACNKNTTPGDKSALTPCGIRIGAPAMTSRGMGEKDFERIAGYIDQCVKLATKIQSELPAEANKQKDFKAKVAGGAASVPELGEIKKDIAAWASTFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM70</accession>
    <name>F9XM70_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_77082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848524.1">
        <property type="nucleotide sequence ID" value="XM_003848476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM70"/>
    <dbReference type="GeneID" id="13396190"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77082"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.457"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="F9XM70"/>
    <dbReference type="OMA" id="SFIGTIC"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="531" mass="59868" checksum="44067B2D733229A5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN04</accession>
    <name>F9XN04_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_101579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
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        <property type="interactions" value="563"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101579"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.232"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="F9XN04"/>
    <dbReference type="OMA" id="SYPESKY"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="7"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="44992" checksum="A12E4273CCC857B2" modified="2011-10-19" version="1">MSNIPGFRSVGYYVNWAIYGRNHQPQDIPADKLTHVLYAFANIRPETGEVYLTDGWSDTDKHYPSDSWNDTGNNVYGCIKQFYLLKKRNRNLKILLSIGGWTYSSNFAVPASTEQGRRTFATSAVCLLKDLGLDGLDVDWEYPKNDAESGDLVKLLQATRYALDEYSNTLPERPHFELTIASPAGPSNCQWLRMREMDQYLDFWNMMAYDFAGSWDSTAGHQANVYPSKDSSKSTPFSIDFAVKYYLQNGVHPSKIVLGMPLYGRAFQQTKGPGKSFNGVGEGSWENGVWDYKALPRPGAKVVEDTSAIASYSYDSSTKTMISYDTPAIAAKKVEYIQRNNLGGAMWWETSGDKVPGGGGGQSLIALTVDGLGGFEGRHMQRKENCLNYPGSKYDNLRGGMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN80</accession>
    <name>F9XN80_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848391.1">
        <property type="nucleotide sequence ID" value="XM_003848343.1"/>
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    <dbReference type="STRING" id="336722.F9XN80"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96701"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.317"/>
    <dbReference type="eggNOG" id="ENOG502S5P0">
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    </dbReference>
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    <dbReference type="InParanoid" id="F9XN80"/>
    <dbReference type="OMA" id="QIGVRNY"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="369" mass="41084" checksum="F69845A7A4627CFB" modified="2011-10-19" version="1">MPPIRTMPAIKPVRTERTHEENQERAYIAASRRSDRSLEARVESARRASEIHKKRTGRSLRVREEDVLNEEMYEEEDDDLPMQFRRINALYPGQAYNAFTERVNNYLAGQVGVRNYLHQAIYQANQHAMNNQFLNPAMQQNAMNGGQQQWQPNMQNDGTRADSPQDQTQQAANTQMQNNAQRMSLSMPAPKSRSSSGQSPTTQKASPTSSRPSIDNSNPLTTTLPIETQQLLDGSSYANQVYPSQFTPGVPMPSTYSYTYNPNSKANNNPGSEQFAFTNKGLNQTLSPHAMHNQPTTPYSDSHSASNAAPSLDFGFGDDMFNDSSYAFDMDFNSAGQHNGLGNLSGNVTPGGDWDSNHDDFFNYAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNF9</accession>
    <name>F9XNF9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_111425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847888.1">
        <property type="nucleotide sequence ID" value="XM_003847840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNF9"/>
    <dbReference type="GeneID" id="13401481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111425"/>
    <dbReference type="HOGENOM" id="CLU_730682_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNF9"/>
    <dbReference type="OrthoDB" id="3646757at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="379" mass="43457" checksum="32942644DC6EF586" modified="2011-10-19" version="1" fragment="single">MPLKAHIPDELLSHIFSFLQPPRPEVLGRARYEHIEWALPDDLPAVDRCSATSEKQYLPQLKTDDAQHKLGLSTLNSCMRACPIAELQAFNRTLFRRPDLTRMVKFITISCDLDPDFCNSLKTCKALRTLEIIWPGMSVDYMQNIYPLSTIIDYKFIGDMICQSFPLLEKLVLDPREAYFGETCRQLRSLDLSSMARLQELAVEACALWGEHAIDSRLPQDIEAPLPGLQDVLPPSIRKLSVLVHRRCDRPRSEVEEVEEIKLQRNQMLILNGALRYLVDAPFSLRSVHLDMPSQEVHEGFDRLDEFFDELGFTRSVVNADPEVQRASPVVGTSTPKDQRVKLRDTFSMWLPGTDRWPTVVIKRLEDAKTEADLARWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP33</accession>
    <name>F9XP33_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848087.1">
        <property type="nucleotide sequence ID" value="XM_003848039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP33"/>
    <dbReference type="GeneID" id="13402127"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97163"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.350"/>
    <dbReference type="HOGENOM" id="CLU_1564131_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP33"/>
    <dbReference type="OrthoDB" id="10320483at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="171" mass="19311" checksum="C65B5EA080EB3B98" modified="2011-10-19" version="1">MLFILSAIELCLLALKTTFEQASSRLSAEHSTTTAILSTLIWMSARLVVSTALLVAISAMKDIGHRHPVSLWSRNTIALKGLVEHFTTYNLLLMTAALISKANDSLLVHGSTAEIILVNAFLMLAFAFVAKTTEYNGRYFVAWVRELNERFVFCFMILRMHFYHPEVWPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP94</accession>
    <name>F9XP94_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_30178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848059.1">
        <property type="nucleotide sequence ID" value="XM_003848011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP94"/>
    <dbReference type="STRING" id="336722.F9XP94"/>
    <dbReference type="GeneID" id="13402104"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30178"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012630_0_1_1"/>
    <dbReference type="InParanoid" id="F9XP94"/>
    <dbReference type="OMA" id="KIPIHAT"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34975" checksum="E73D7B0A14ABBF45" modified="2011-10-19" version="1" fragment="single">FRHLAWVEHHDAEDGAAMRRFFALLNECVSENVRLNDMVWNTAISFSGRWMRRVTGDRVKAAVQTWMQMEGAGQQATNVTFNIIFDLAVRSGRYALADTIFEELKARKMPLNRYFRTSVIFYAGMKRDGDGVRKAFRELVNAGEIVDTAVMNCVIVSLLRAGEAPAAETVFARMIRLHEEKCGTAPPTDWREMKELGGLLNETGEKLRREESRHEASFFGGKFSMGKKREELQKAAPIAPNANTYRIMIKYHAHTSGDLPRIHALLAEMKEKDFNVHGSVYVHVLRGFAAHGGFAFSAWSRMSLENLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPP5</accession>
    <name>F9XPP5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_77707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847812.1">
        <property type="nucleotide sequence ID" value="XM_003847764.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13400819"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77707"/>
    <dbReference type="eggNOG" id="ENOG502S4VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042303_0_1_1"/>
    <dbReference type="InParanoid" id="F9XPP5"/>
    <dbReference type="OMA" id="IHGTHTE"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="325" mass="38019" checksum="61AC471CC8937E86" modified="2011-10-19" version="1">MDERLVHPAQLYDYVNDYLRLIKPQPMVRVQGWHWQTRQRVGKRENKTQQERVYDFDVVLSMHNFLPSSTDRDAADDVWWVPHSVENSDKAHRGSWRKTRAKGSTQHIEVGEDRKPELLDWCEDFCSNTSALKIFRVSRNVTGLDTDAIQEMIVPLVRQTHYRGHINITFPIADKNVDIYSPHWINRARMTWVRWIFYLTFLWIFTWPVLLFTTKRWGVYKVDWRFSHEFVESDGTRRKRYATISEHEWVRRHANLIKSLVLDKFHGDATTFPTDVDEADAQRRRISMPRAGNGSLDSALSFIQGGVGAWGALNGRGGDGWGADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ20</accession>
    <name>F9XQ20_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847587.1">
        <property type="nucleotide sequence ID" value="XM_003847539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ20"/>
    <dbReference type="GeneID" id="13401185"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97384"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.188"/>
    <dbReference type="HOGENOM" id="CLU_2075010_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ20"/>
    <dbReference type="OrthoDB" id="10313915at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="13319" checksum="F3CE146420EE9A51" modified="2011-10-19" version="1">MEHNTSSTPSEAEENYLSTPELLQLLATGHRKIAEVFVKAAKDHGWKYLDSSMDDEMAVARYMEGLRKADEHLIDRLIKQGAAPKGRFEKCLSDPEVHEKILASIYMPREDSTAKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQE2</accession>
    <name>F9XQE2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_106559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847695.1">
        <property type="nucleotide sequence ID" value="XM_003847647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQE2"/>
    <dbReference type="FunCoup" id="F9XQE2">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQE2"/>
    <dbReference type="GeneID" id="13401053"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106559"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.326"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="InParanoid" id="F9XQE2"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="116" mass="13063" checksum="ABEA507A18DFA75E" modified="2011-10-19" version="1">MSAGIENLKSFDPFAEADEGEGEAKQSGNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVNDTEMGEVIQLQGDQRKDVQEFLIDKKEGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQG4</accession>
    <name>F9XQG4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_78016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CM001208">
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    <sequence length="962" mass="107192" checksum="3356D5A71210EB52" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQJ4</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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    <accession>F9XQS6</accession>
    <name>F9XQS6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="van de Geest H.C."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97599"/>
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    <dbReference type="InParanoid" id="F9XQS6"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="15469" checksum="D55B0617B96E499F" modified="2011-10-19" version="1">MVHGIRHDLFETAYTILQSLDKTSHFLRQGVPPGVLRRAVLSQIMTVVAIVMSVELLVLVHVKISNWELWKFYYTFLCGNSVASQGVCIKVEDTRDNRRQIHHVDDKFLRHSYANVVDVIQCCGRNTASWRQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRC2</accession>
    <name>F9XRC2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847253.1">
        <property type="nucleotide sequence ID" value="XM_003847205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRC2"/>
    <dbReference type="GeneID" id="13399910"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97776"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.105"/>
    <dbReference type="HOGENOM" id="CLU_1429054_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRC2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="190" mass="21024" checksum="DEFE78A578A2CD5B" modified="2011-10-19" version="1">MSAQELSDPAVEYRWHNHRLRSYSQEASDPADFGDTLPVRGAPSDPVDFYDTSPDAPLPLDTGALLQDSPSADLFHPHTILILAPIFFTGWKAFHRAGAVRLTQADIVAPEGLGIAETVQEETKVEDELLAKVSVTQETGEQAPAILAAAEEHRRRYERKTTWCQSLVYNDRLRHFGKSQGAKASRSCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRJ0</accession>
    <name>F9XRJ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Shugoshin N-terminal coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_97837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847170.1">
        <property type="nucleotide sequence ID" value="XM_003847122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRJ0"/>
    <dbReference type="GeneID" id="13399672"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97837"/>
    <dbReference type="HOGENOM" id="CLU_535521_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRJ0"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="10">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="509" mass="56085" checksum="64735BDB3940AEA4" modified="2011-10-19" version="1">MRTKSRAPEEKPATDINEVKRRSIRQNRELAKYSSAQFLKIQSLHLEISKLLSNNLQLRERVLGLENQLQDTRRQASNATIGRVKAHDQESETNNLELQERVPGLENELQGARRHASNAAIKADLRSKLAELSGMVEELEDDGTADIDFEREVVGSALHWVRNGPRELAELRGDGTYGVVLIRGGLQLTSRLICFLFLSLTPLPPYQPFEFALHNPTELIFLARPAVEITSVNLHLDVLAHLAIHSNLRTECALSLIALLSDSDCVRLGGVRYPYFYRLFGPMPCRLPAIRERQSENSFSGHADGWKDWTEVHRKARIDITLRLSKSAATGSPDIGPPPAAHLILTAGRRIEECEGCVPAHPGRGLATVNLETRRKQKNIASELEMRRSSILAQSLVKPARDVAPWPLRTGANMEEAGGSRCIFLVLTICLSFAALSLSSCSYRSEPSSTSPSLVIHVAAFVHPSHTSITSRASPNFARRIVQHGAKAFNISNALGPVLVCGALGAAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRN1</accession>
    <name>F9XRN1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847087.1">
        <property type="nucleotide sequence ID" value="XM_003847039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRN1"/>
    <dbReference type="GeneID" id="13399477"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106653"/>
    <dbReference type="HOGENOM" id="CLU_3052151_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRN1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="54" mass="5954" checksum="9D331CF2DA9D4700" modified="2011-10-19" version="1">MRSHGAGWAWAWAPPPPPPTGWERSNEQMVNTLKRDSRQGARVGRGAEGEEISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRS0</accession>
    <name>F9XRS0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847073.1">
        <property type="nucleotide sequence ID" value="XM_003847025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRS0"/>
    <dbReference type="GeneID" id="13399232"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97915"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.4"/>
    <dbReference type="HOGENOM" id="CLU_1409826_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRS0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="193" mass="22012" checksum="543FDA254CFF4BB6" modified="2011-10-19" version="1">MSPNRRNSDLSQASSTPLERARHEAASNNDFGTGYDSDPDDLFLVHPATVLMVDKKKKAAAPRNVFTTEEEDQVILDNFKQYPKGMNIPFTNRYEMMKNSLLGRSGETTRRRWQRHLDPNRNGKEIQAKEERDSKRQRFLQHLAKSHLKDPDMGLDDRVKTVEESTGDATNRSAIVAGIKHLRAEGIISKNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS85</accession>
    <name>F9XS85_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846908.1">
        <property type="nucleotide sequence ID" value="XM_003846860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS85"/>
    <dbReference type="GeneID" id="13396671"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98074"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_21.5"/>
    <dbReference type="HOGENOM" id="CLU_2160410_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS85"/>
    <dbReference type="OrthoDB" id="10625307at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="111" mass="12843" checksum="807173C576CE658F" modified="2011-10-19" version="1">MFILRMEAQSSPWRDRRICSLLLDVLREIAASARYFWKVTLTQQIQDQTIDKDLNGFKRAIPDNETRVMALNELACEHGEGFLYYLPSRDVWKTNAEADILPVSRRTAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS95</accession>
    <name>F9XS95_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846902.1">
        <property type="nucleotide sequence ID" value="XM_003846854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS95"/>
    <dbReference type="GeneID" id="13396659"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98085"/>
    <dbReference type="HOGENOM" id="CLU_380916_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS95"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="727" mass="81813" checksum="E1273B106D5AD60B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5G8</accession>
    <name>A9Y5G8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cox3</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648739.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5G8"/>
    <dbReference type="FunCoup" id="A9Y5G8">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="336722.A9Y5G8"/>
    <dbReference type="GeneID" id="5846240"/>
    <dbReference type="InParanoid" id="A9Y5G8"/>
    <dbReference type="Proteomes" id="UP000008062">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
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        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABU40255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="30126" checksum="446BD9FFB1C19BC3" modified="2008-02-05" version="1">MSNLNRSVFQGHPFHLVSPSPWPILTCVSLLDLTTSGVLSMHGFTYAAYWLPLALILLMSSMFFWFRDVISEGTYIGNHTLAVQKGLNMGVSLFIISEALFFLAIFWAYFHSALSPTVELGAQWPPMGIEAINAFELPLLNTVLLLASGVTITYSHHSLIQGNRNGALYGALFTIVLAVVFTLFQYVEYSVSSFTITDGAYGSCFYFGTGFHGLHVIIGTMFIAVGFWRLVAYHLTENHHLGMEGAILYWHFVDVVWLFLFLSVYYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW90</accession>
    <name>F9WW90_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MAD2</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_33976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003857527.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13403146"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33976"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.522"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW90"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:anaphase-promoting complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="230" mass="25881" checksum="9F8A8A3347FE642E" modified="2011-10-19" version="1">MPAATKAPSDDRAKTHKLSLRGSSKLVTEFFEYSINTILFQRGVYPAEDFSAVKKYGLNMMVSLDDQVKAYIKKIMSQLNKWMQKSKISKLVIVVTNKETGEHVERWQFDVNIFNDDSKSSARRSASTDKENSAPMPDAASSQQEKTESEIQAEIQALFRQITASVSFLPMLDGNCTFNVLVYADADSEVPLEWGDSDAKEVKNAEKVMLRSFSTNSHRVDTVVSYRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW97</accession>
    <name>F9WW97_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_102191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW97"/>
    <dbReference type="FunCoup" id="F9WW97">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WW97"/>
    <dbReference type="GeneID" id="13403141"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102191"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW97"/>
    <dbReference type="OMA" id="WSTAVMG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24933" checksum="40FE3550C2186214" modified="2011-10-19" version="1" fragment="single">MASPSLPLKKSLTPLAFQLQARNLTSRAFTTSSVRRLQDEPTPSNLNTPRPSRSKPLSHAQKKFLDSALRVNHAGELAATLIYTSQTPPIAKAHPHLRPLMKHMYDQEAGHFKKFNELLAKHRIRPTAMYPVWHAAATVLGWGTGVMGREAAMACTEAVETEIGDHYNSQVKELLAWFRDMEERGEEPGEELTELVKDIRRIRDEELEHLDHAVENDAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXN3</accession>
    <name>F9WXN3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific actin related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARP2403</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_52213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856004.1">
        <property type="nucleotide sequence ID" value="XM_003855956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXN3"/>
    <dbReference type="STRING" id="336722.F9WXN3"/>
    <dbReference type="GeneID" id="13403220"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52213"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.372"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXN3"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="511" mass="56584" checksum="2957ACA91A44BDDE" modified="2011-10-19" version="1">MATSTTPARLPLRRGPSGTLREATASPRSPHTPLLGRSTSSQFGSPGTFRVEQEDVVVYELGATHFAAGFAGESRPRCVLQFSHDTARRAGDYRQYDPQYAKLSRRWRVGGEWGIDHELYKIDLTELDLGLVEDKLERALRTAHIDYLQLDTKSRKAVLTVPSLLPNPLLELALRVLFAHYTQPPTIVVLTHPIMCCVSAGVRNALVVDIGWEETVVTAVGEFKEVSQSRSVRAGKMITREMGNLIEEGVRMRGEEDDTMKVTFEDAEDITQRMAWCQPRERSESTEQASVVQLPVPGSVPSATFPMPFDRLAEPVEKSLFQSAEQDDHNLPVHLLAYRVLLGLPADLRALCMARLIITGGASNVPGLKRRILQELSHLVFTRAWDPVENYGSATAHHEKAMKEISDNIASRRNRPSPEMPTFSPIKMPLQESVPHGDRVHDDLRDPITLAAEQEAARGKTTPITGVLRGVETLGPWAGASLVAAMRIKGVHEVEREDFAKHGLKDLGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXU0</accession>
    <name>F9WXU0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_65593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856109.1">
        <property type="nucleotide sequence ID" value="XM_003856061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXU0"/>
    <dbReference type="STRING" id="336722.F9WXU0"/>
    <dbReference type="GeneID" id="13403106"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65593"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.600"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027981_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXU0"/>
    <dbReference type="OMA" id="PTCPICM"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="542" mass="58755" checksum="32BAA95591C73BE8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYJ5</accession>
    <name>F9WYJ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_34317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856970.1">
        <property type="nucleotide sequence ID" value="XM_003856922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYJ5"/>
    <dbReference type="GeneID" id="13398123"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34317"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1858"/>
    <dbReference type="eggNOG" id="ENOG502SJ1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_1"/>
    <dbReference type="InParanoid" id="F9WYJ5"/>
    <dbReference type="OMA" id="WIERGEE"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29145" checksum="E68FF257C16A80AD" modified="2011-10-19" version="1">MATSIPWTSIKVVTFDIFGTLLDDERGLAAAARATSLAPYLPSSHADLIRGIKAHDSIIQRETPTMLQRDVVAEGFRRYAKDIGVVEKGQLAQEEVETAAREYGGKMGEYPAYEDSVAAMQSLKKRYRLIPLTNVDHQSWKEVIGGPLKGCDFDAVYMAEDVGSYKPDLRNFRYLFDHVKQEFGLEMDDICHLAQSLTHDHGPAKELGLRSVRVDRKGLMDGDPVERQEKYGYHLRVQSLKELAEIVEQAFEVVVRQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYJ7</accession>
    <name>F9WYJ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_20676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856969.1">
        <property type="nucleotide sequence ID" value="XM_003856921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYJ7"/>
    <dbReference type="STRING" id="336722.F9WYJ7"/>
    <dbReference type="GeneID" id="13398124"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20676"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023305_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYJ7"/>
    <dbReference type="OMA" id="WVAWPKA"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="191"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP91945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="567" mass="62376" checksum="0BAA8369F1E1F0E6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYV8</accession>
    <name>F9WYV8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_88946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856030.1">
        <property type="nucleotide sequence ID" value="XM_003855982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYV8"/>
    <dbReference type="GeneID" id="13403969"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88946"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.419"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033641_3_0_1"/>
    <dbReference type="InParanoid" id="F9WYV8"/>
    <dbReference type="OMA" id="MAGLNKW"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="76"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="371" mass="40301" checksum="0B4A0F66C71BE2A5" modified="2011-10-19" version="1">MQKPTTNYDTDEEKVSLDDGVRSSLSESWKEHSSGRSSEEFTHKPTDGILEVDDRDVESQGIIAPENYVSTQAKLLFLAAYMTLNLFLTLSNKAVLTRARFPWLLTALHASATSIGSLAMLGTGYLKLSHLGKREQMVLVAFSLLFTINIAISNVSLAMVSVPFHQIMRSTCPVVTILIYRWVYGREYATMTYFTMIPLIFGCAVATAGDYNATILGSALTLLGVVLASVKTVASNRLMTGSLKLSALEILLRMSPLAAIQCVAYAFMTGEVSKLRTAYLDGTFSTDFGAHLLINAITAFLLNIVGFQANKMAGALTITVCGNVKQALTILFGIVLFHVEVGVVNGIGMIITILGAVWYSKVELDNKQAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ59</accession>
    <name>F9WZ59_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856267.1">
        <property type="nucleotide sequence ID" value="XM_003856219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ59"/>
    <dbReference type="STRING" id="336722.F9WZ59"/>
    <dbReference type="GeneID" id="13402957"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102408"/>
    <dbReference type="eggNOG" id="ENOG502S9SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670749_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZ59"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="158" mass="17296" checksum="7179F676913DB724" modified="2011-10-19" version="1">MLTVAEGMAAGSGSDSDSDDDVDGIDGQTTGDGEGKRRRNRGKKSKRRKQREEREGVSGSSTPQNGSLGVPSSQQPSRTQSPRLPATALEKLSELHDKLQTYMPDCRAFEASPPAEPAKREFEHKRLSETILAQVLLKLDAVETEGDAEARSQRRKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZB9</accession>
    <name>F9WZB9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_102581</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856411.1">
        <property type="nucleotide sequence ID" value="XM_003856363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZB9"/>
    <dbReference type="SMR" id="F9WZB9"/>
    <dbReference type="FunCoup" id="F9WZB9">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZB9"/>
    <dbReference type="GeneID" id="13402825"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102581"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_2_1"/>
    <dbReference type="InParanoid" id="F9WZB9"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="429"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP91387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="635" mass="67764" checksum="507470E215522032" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZS2</accession>
    <name>F9WZS2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_65399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZS2"/>
    <dbReference type="STRING" id="336722.F9WZS2"/>
    <dbReference type="GeneID" id="13394301"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65399"/>
    <dbReference type="eggNOG" id="ENOG502RZF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="FHMPRID"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="370" mass="40954" checksum="DB498F3B8540E3D8" modified="2011-10-19" version="1">MLGWALLIYALAAVLVFGTGFLTNSINNALSPVCRLPFTSHLSFCPSKSAGEVHGTAEFDKLVQAQDAFQDVLASTSIGATLPLDMKRSEASIRDLKHVVEYSSLPSKNELVFEFGGFIDTARQASQDLSRFNSRIGRAVDHILSTNRWTLSVIDGVSETEASRGAISKWMGKNLNIFSPFQPVSLSRDVLLDQYLRHTSAVEEQILNLIAEAYALRDILENLDGRLDVIAGIATRDGIKTEMNKDELFATLWTKLGGNRSSVSKINQQLELLKNVSAYRRQAWGHVTATLLKLQEIQASLEDLRERVAMPETVGTAKVPLDVHIENINRGIERLENQRDSSRKLEAENYARIVGKAEANEKKSLGGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X091</accession>
    <name>F9X091_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_3_0_1"/>
    <dbReference type="InParanoid" id="F9X1D1"/>
    <dbReference type="OMA" id="HIDKRTR"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24350" checksum="BB7AEEDB673FE6D6" modified="2011-10-19" version="1" fragment="single">LIKAEIIPTVLDTFHPLLTVTLTWPPKHYRKDKPNDKHRTQLGNTLKPKYVQRRPRIELLSDLPDVFNSISAVAGGDHERDHPQLTLVLTDPDARSRDDPDWSEMCHWIVTDVPLILPSTPKLSSSLSSNQDVEIEMQEIMPYKPPGPPASTGKHRYVAVALAPINGTMEKLRLSRPADRKHWGYGGERVGVRQWAEENGLGVVGANFIYAQDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1L1</accession>
    <name>F9X1L1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_107760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856892.1">
        <property type="nucleotide sequence ID" value="XM_003856844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1L1"/>
    <dbReference type="FunCoup" id="F9X1L1">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1L1"/>
    <dbReference type="GeneID" id="13398269"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107760"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2006"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1L1"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="251"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP91868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="52455" checksum="5316761B32F58797" modified="2011-10-19" version="1">MPREIITLQAGQCGNSVGSQFWQQLCLEHGINQDGNLEDFATSGGDRKDVFFYQSDDTRYIPRAILLDLEPRVINGIQTGPYKNIYNPENFYVHKEGAGAGNNWAAGFDMGATVQDELMDMIDREADGSDSLEGFMLLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTQGQGSGDVVVQPYNSLLALRRLTQNADAVVVLDNGALSRIAADTLHVQKPSLQQTNQLVATVMSAATTTLRYPGYMHNDLVGIMASLIPTPRCHFLQTSYTPFTGDNVEAAKTVRKTTVLDVMRRLLQPKNQMVSTKPSKSSCYISILNIIMGEADPTDVHKSLLRIRERSLASFIPWGPASIQVALSRTSPYLSPPYTSTPPPRVSGLMLANHTGIATLFKRIVWQYDRMRNRNAYLEQYKRYDSFRDGFGEFDESKEVVMDLVGEYEAAEKADYLSGEQEEGEGKEDGRTDGGATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1P3</accession>
    <name>F9X1P3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856833.1">
        <property type="nucleotide sequence ID" value="XM_003856785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1P3"/>
    <dbReference type="GeneID" id="13398391"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90294"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2098"/>
    <dbReference type="HOGENOM" id="CLU_806997_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1P3"/>
    <dbReference type="OrthoDB" id="5227598at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="344" mass="39141" checksum="5A78F5F2E5ED4409" modified="2011-10-19" version="1">MRRFTNKLRNLFQRDRKPMASTEDDPRNISHDSQRFSDKLKRLFRSKRKPIHSPHHPSPEYKAPNGMTKYRLQDLTLPRFPYEYDPNKPLAWHTSRPPTPEGTILNQWNQAPTWSALLDLNRAFLRGQIPITPYAHLLHLSDMAPCIASLLMLHKYGLLTLSAQPSSPGHPVYGLCRPAQDRVQEYAWEQDQLLSFLTFIVPGRPDNSACTAGQVSGFLDILLTHPDVYAHVMRSEGAWDQLDRPCGRVDVKARSSFPGFWGTHVARVARTKEGIEGAEVRHLRCFSLEDHKVLWWLSCDAFEKNEPVLVRVLARREEEGDLMGLVGEAARRAGMGSVFGEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2N8</accession>
    <name>F9X2N8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear protein SNF4, regulatory protein CAT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgSNF4</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_68009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855687.1">
        <property type="nucleotide sequence ID" value="XM_003855639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2N8"/>
    <dbReference type="FunCoup" id="F9X2N8">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2N8"/>
    <dbReference type="GeneID" id="13396011"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68009"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.301"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2N8"/>
    <dbReference type="OMA" id="YTCSPDD"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="413" mass="46075" checksum="0D643564EE681789" modified="2011-10-19" version="1">MDLNNETLSNSSIKPNQANPEQSHASILDDSQSLQPGHESAVAAEHGASTDTNRPTIAHTDESRSTPSPFPAAPSHFLRPSRAATRPSNVKRPMTSLDKEQIDGLRAIRAFLKVRTSYDVLPLSYRLIVFDTSLLVKKSLNILTQCAIVSAPLWDSKTSTFAGLLTTSDYINVVQYYWQHPSALEQVDQFRLNSLREIERAIGVTPIETVSIHPLQPLYEACRRMLESRARRIPLIDVDDETQREMVVSVITQYRILKFISVNVKETQWLRKPLRDLNVGTYTDVATATMDTPVMDCIHMLVKKSISSVPILDADGTVLNVFEAVDVIALIKGGDYENLNLSVGKALDKRSDDFPGIYTCTLNDRLDTIFDTVRKSRVHRLVVVDEAGQLKGLLSLSDILDYTLNSPLGDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2S2</accession>
    <name>F9X2S2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XRCC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_54971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854840.1">
        <property type="nucleotide sequence ID" value="XM_003854792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2S2"/>
    <dbReference type="STRING" id="336722.F9X2S2"/>
    <dbReference type="GeneID" id="13403607"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54971"/>
    <dbReference type="eggNOG" id="ENOG502QWJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044616_3_0_1"/>
    <dbReference type="InParanoid" id="F9X2S2"/>
    <dbReference type="OMA" id="EISFLEW"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="223" mass="24998" checksum="3F6FE06BA6093005" modified="2011-10-19" version="1" fragment="single">MVSLILRVRRQEKQAHPGHLLIHIDHIGPKPLDLKLIGTDHSHLYHASLEQSSLKSLQASNFTGDLQQWKTTIAYAFLHQTPTGPFPEFLRGVELVAKITRVSDEKGTVTITVRRNIGGITQTLGSLDLEQDDTREEVGFVEWVDVAAATADDLRLQLDQSLASSSAQQDRITQLTAELDQLVKAKREHEDELLSKFAALLNTKKLKIRDQQRLLSRANVNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X322</accession>
    <name>F9X322_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855040.1">
        <property type="nucleotide sequence ID" value="XM_003854992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X322"/>
    <dbReference type="STRING" id="336722.F9X322"/>
    <dbReference type="GeneID" id="13400990"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68660"/>
    <dbReference type="eggNOG" id="ENOG502SHE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
    <dbReference type="InParanoid" id="F9X322"/>
    <dbReference type="OMA" id="EPVLAYW"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395296" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59354" checksum="A31FAE546379CC7A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X361</accession>
    <name>F9X361_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_68955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855137.1">
        <property type="nucleotide sequence ID" value="XM_003855089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X361"/>
    <dbReference type="GeneID" id="13400735"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68955"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="F9X361"/>
    <dbReference type="OMA" id="MADHIFR"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30407" checksum="0610C82974DE0862" modified="2011-10-19" version="1">MAPTNNIQDLFSVPGLVAVITGGGSGLGLYAARALDANGAKAVYILGRREETLKTAASTGVNGRIIPIACDVTDKASLAAAADQVRREQGYINLLFANAGIGGPNNASAAKREDGSQASPKEFADACLQPEMAEVTKTMHVNNTSVLYTVMSFLDLLDLGNKQQNVAQDSQVIVTSSIAGFSRAMATGFAYSTSKAAVTHLVKMMSTSFAQQGFRIRANVIAPGLYPSELTANSVDQVMEKERCPSLRTGSEEDFAGTFLYMASRAGAYLNGETLVTDGGRLAQMPAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3A1</accession>
    <name>F9X3A1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855154.1">
        <property type="nucleotide sequence ID" value="XM_003855106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3A1"/>
    <dbReference type="GeneID" id="13400247"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103434"/>
    <dbReference type="HOGENOM" id="CLU_3108215_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3A1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="51" mass="5991" checksum="E48392761E2988A8" modified="2011-10-19" version="1">MDLSLDTDEAWRRRNNVQFILFEIDIARIQTTALSGKRCGKRIDSIGSHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3D0</accession>
    <name>F9X3D0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_67804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854753.1">
        <property type="nucleotide sequence ID" value="XM_003854705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D0"/>
    <dbReference type="GeneID" id="13395938"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67804"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="F9X3D0"/>
    <dbReference type="OMA" id="HGFPYTY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="69125" checksum="88957E64898FD309" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3I4</accession>
    <name>F9X3I4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_107963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854860.1">
        <property type="nucleotide sequence ID" value="XM_003854812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3I4"/>
    <dbReference type="FunCoup" id="F9X3I4">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3I4"/>
    <dbReference type="GeneID" id="13399349"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107963"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.372"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="InParanoid" id="F9X3I4"/>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="120"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="552" mass="60064" checksum="425AE150611E56BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4V8</accession>
    <name>F9X4V8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_12167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
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                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <dbReference type="EMBL" id="EGP89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="76043" checksum="8FC7A96C48A91192" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5H2</accession>
    <name>F9X5H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_39259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853706.1">
        <property type="nucleotide sequence ID" value="XM_003853658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5H2"/>
    <dbReference type="GeneID" id="13404044"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39259"/>
    <dbReference type="eggNOG" id="ENOG502RKWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_4_0_1"/>
    <dbReference type="InParanoid" id="F9X5H2"/>
    <dbReference type="OMA" id="HPITFWG"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53663" checksum="648A2137DD125E9B" modified="2011-10-19" version="1">MYFPSLPLDSPNSSLFDTFGSISQSELPAEAADVWPARVHEHNLLPWIDVYFKRLHPTMPILNRANMYCEMLLRKHRTDPQYGAMLLGLCAFAMTQPVQIHERGSIASRSVQARMLMEECVRMRMAPDFGEDPTIETILASFFLFACLFGSHQHKAARHKLREAVDLAYSLGMHLPQSYTGLTRELREQWLRTYLVLSVTERAYALQQSHSISFRGRPGITARFMQAFDPSATNEYISSLIYQDRADAVGMTALLYLMDTFDAIDESVMDCWNGYCRFSDGACESFDRRRALQMFRAQHRVRDACLTGTILFAPSVEPLPMAQLLESQQIDISVTQLWLLGRLWQLCLTHGMLRETSDHAELRFDFAFRIGLILMSSCNVYSLSAMEVHGVGLVEKVYDVAMGVITAMSSCSSLHLDLVILSDSDVIASPHPVIETKVRELLNGFASLMREFRGGDHKYNAQFETALAGIPGFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5P1</accession>
    <name>F9X5P1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_99562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853856.1">
        <property type="nucleotide sequence ID" value="XM_003853808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5P1"/>
    <dbReference type="FunCoup" id="F9X5P1">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5P1"/>
    <dbReference type="GeneID" id="13404194"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99562"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.568"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="InParanoid" id="F9X5P1"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="641" mass="69464" checksum="1D13DE308DF87D70" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X606</accession>
    <name>F9X606_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_39000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853651.1">
        <property type="nucleotide sequence ID" value="XM_003853603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X606"/>
    <dbReference type="STRING" id="336722.F9X606"/>
    <dbReference type="GeneID" id="13395826"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39000"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.86"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="InParanoid" id="F9X606"/>
    <dbReference type="OMA" id="DPCTHRV"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="342"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="54373" checksum="15EE38B2E52DBABD" modified="2011-10-19" version="1">MDSPLAAIKLLFPHVPSLSWTAAQHTLGISPTASKWDLRSELTVHVLRAIASPKSGRPAPLSKVQRGTLKDPGVKGKTWIAKATIPRPPKEDEGQGKGLRDVVFQAIEAMKKEGNVLHYEKPELKDLEVEWTGFRPGAKKDEGLPDVDEKDKYRLLMAEPCRSSEATVLYFHGGAYYLCDPATHRGLTSRLAKESSGRVCSVRYRLAPQTAFPGQLIDALMAYLSLIYPPSNSLHEAVPAERIVLAGDSAGANLAFALLQLLLQLHRTADGVPLVKFHGRDVHVPLPAGVSGNSGWFDVSRAMPSIVGNSKWDYLPPANHDDAVGRFPADSIWPTKPPRGDIYCDLSMLDHPLVSPVLAESWKASPPLWMNTGDEMLMDEVILVAARAAGQGVKVHFEHYEAMPHCFPMLLPHLPASRRCLRSWGNWIRRVVEEPEGLKTNGVWIPARKGKEKEVDVMRLPAVEFGEARRLVGVIKERRIQGFKKGEGVKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X620</accession>
    <name>F9X620_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_91371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854632.1">
        <property type="nucleotide sequence ID" value="XM_003854584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X620"/>
    <dbReference type="GeneID" id="13395819"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91371"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.101"/>
    <dbReference type="eggNOG" id="ENOG502T7D7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582930_0_0_1"/>
    <dbReference type="InParanoid" id="F9X620"/>
    <dbReference type="OMA" id="VHMANDS"/>
    <dbReference type="OrthoDB" id="10395784at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="469" mass="51693" checksum="EFD697C43631485F" modified="2011-10-19" version="1">MASPTSPSTPPSPPSTHQLPQRRRRTVAFFEPLPSTPRSPRQPQAQISNFAHRRTSSSTTINPQHRRFAPTAGHQLFRTLKPLVWTLTAVLLILLPTLAGFAVMKIVLRGACSIFPAATPGCGGYIHSGLARHTSPTTAKSTVLSGSFAALEPLTEMSPTLEFVGYAMFLASFNLTATLDILGPLAGSNATEGGPLGERRLKGLAMAANKASFGVDAWTGSDYVFRHEGFVRGGMEGVEGRGVGWLSGRLGEVVEGRRDGWKEKVLGRVVPYGGRWGVESRILGVYGEFLEVQVKAVEEMVVLTKGARLAVGKWREEVRGLERGLERYDERSYDGWFVRPREGCAFDAREEGRRVRGVGEAVRWMADVLARAEELYVGLLREVVRAREEIEMGKSRVRSLFGGSAVGEEALKELLNRERKQMDEVMKSDRAGMAIVEEIGNELMEAEDDGLAVKRKMEAAIAERRIEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6D1</accession>
    <name>F9X6D1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein mrp10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_29515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854367.1">
        <property type="nucleotide sequence ID" value="XM_003854319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6D1"/>
    <dbReference type="FunCoup" id="F9X6D1">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6D1"/>
    <dbReference type="GeneID" id="13395553"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29515"/>
    <dbReference type="eggNOG" id="ENOG502SBQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162186_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6D1"/>
    <dbReference type="OMA" id="INYHAAR"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9014" checksum="6BA5CC46EDF5DC13" modified="2011-10-19" version="1" fragment="single">LPPLPKLRVRKPNSSDANPCVAVMSSMLGCWASQGYTTAGCATIEQQLRVCMDARKPGAAKKSTINHHLSRFYPQIKGPFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6V1</accession>
    <name>F9X6V1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853780.1">
        <property type="nucleotide sequence ID" value="XM_003853732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6V1"/>
    <dbReference type="GeneID" id="13404119"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103676"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.409"/>
    <dbReference type="eggNOG" id="ENOG502TB1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1652794_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6V1"/>
    <dbReference type="OMA" id="WGRNDPL"/>
    <dbReference type="OrthoDB" id="3905156at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="155" mass="16083" checksum="66F91E408CB815F4" modified="2011-10-19" version="1">MASQYQGPGATLWAHMPPPAECLAILVGCAEVVVFGLGGLANPSDFSNGYGLPIDAATEGVQATQSQKTQSALVKAIASRHVQNGALILTFGLYTRNRTALGFAVAYSAISALADTLLVKNNGVDSLAGGHVIAALNSLLVGGALLYWKRDDKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Z0</accession>
    <name>F9X7Z0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MgTpk1</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_38697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854294.1">
        <property type="nucleotide sequence ID" value="XM_003854246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7Z0"/>
    <dbReference type="STRING" id="336722.F9X7Z0"/>
    <dbReference type="GeneID" id="13404322"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38697"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="F9X7Z0"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="58"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP89270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="382" mass="43918" checksum="1F336058C02128FE" modified="2011-10-19" version="1">MSQSSSAEKENTAAREEEKQKLSEWEAEKRPLEVEEIAVDPEKKPVGHSSKLLRKEDFELIKTLGTGTFARVWLVRLANQKNTSNNEYTKKVFALKILRKVDVIRLKQVEHVRNERNVLAAVAGHPFITTMVASFQDADTLYMLLDYCPGGEVFSYLRRARRFNEATSQFYAAEIVLILEFLHEKEGVAYRDLKPENILIDADGHLKLVDFGFAKKIAGRETYTLCGTPEYLAPEVIRNTGHGLAVDWWAFGILIYEFLVGQPPFWDQNPMKIYEQIVEGKVRYPSAMSEDARDIIGGLCTVDVSKRLGNVKGGAATVRSHPWFKNIDWDELYHRKMQGPIVPHLRSADDTRNFDDYDPEPEKRDPYTKELQDKHERMFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X899</accession>
    <name>F9X899_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_109019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.239"/>
    <dbReference type="eggNOG" id="KOG0691">
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88487.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="362" mass="41019" checksum="A79A6081A4F08FAF" modified="2011-10-19" version="1">MASQLVSLGGWYFLPNLVTGYAQTAAYSIFIRAGDPKPAPGSQRYIRDRRRIHVAVIILYLLYTVYEADYQLRQQGDFYQLLGVPHNVDDRSLQSRFRRLTVQFHPDKATGSDKASIEAIYVRLKAARDTLVDPAKRFAYDRFGPDILRWQSCKTLPDYVYHGLQQLSVYYATSAIALIVLGLMGYLNNGMFWRYFVMGTLFVVEMYTITRPHFPVLLEKFINPFLITTGLRPPYLPFQMIILLRKIAVTFFIAMSQLGPLLQSASPGMEDPAVVSMQQIQRIEAVAAAVDTELSRLIAMEVIPFGNDEASVGELKEGLVDWLKVNTVRNDPEVRAAMARVLERRRAEGRDPGGERPAVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="191"/>
            <end position="516"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="52"/>
        </location>
    </feature>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="695" mass="75137" checksum="39DA665E637861CC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9A7</accession>
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        <recommendedName>
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        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MgMYO1</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853173.1">
        <property type="nucleotide sequence ID" value="XM_003853125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9A7"/>
    <dbReference type="FunCoup" id="F9X9A7">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9A7"/>
    <dbReference type="GeneID" id="13399537"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40326"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="InParanoid" id="F9X9A7"/>
    <dbReference type="OMA" id="PPEEYQM"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="22"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="22">
        <location>
            <begin position="759"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="1061"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="927"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1027"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1116"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1163"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132368" checksum="59657E5B4A428098" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9R4</accession>
    <name>F9X9R4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_71375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853330.1">
        <property type="nucleotide sequence ID" value="XM_003853282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9R4"/>
    <dbReference type="FunCoup" id="F9X9R4">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9R4"/>
    <dbReference type="GeneID" id="13399292"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71375"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.609"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="InParanoid" id="F9X9R4"/>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="673" mass="72695" checksum="FDD92A97B3D82B7C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9V3</accession>
    <name>FER7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Siderophore transporter MYCGRDRAFT_70577</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ferrichrome A-like siderophore biosynthesis protein MYCGRDRAFT_70577</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">MYCGRDRAFT_70577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="631" last="631">
            <title>In silico prediction and characterization of secondary metabolite biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.</title>
            <authorList>
                <person name="Cairns T."/>
                <person name="Meyer V."/>
            </authorList>
            <dbReference type="PubMed" id="28818040"/>
            <dbReference type="DOI" id="10.1186/s12864-017-3969-y"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Siderophore transporter; part of the gene cluster 14 that mediates the biosynthesis of a ferrichrome A-like siderophors which may contribute to organismal virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852791.1">
        <property type="nucleotide sequence ID" value="XM_003852743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9V3"/>
    <dbReference type="SMR" id="F9X9V3"/>
    <dbReference type="EnsemblFungi" id="Mycgr3T70577">
        <property type="protein sequence ID" value="Mycgr3P70577"/>
        <property type="gene ID" value="Mycgr3G70577"/>
    </dbReference>
    <dbReference type="GeneID" id="13397142"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70577"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.4"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="InParanoid" id="F9X9V3"/>
    <dbReference type="OMA" id="LAPKPMM"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF58">
        <property type="entry name" value="LOW AFFINITY HEME TRANSPORTER STR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000451096" description="Siderophore transporter MYCGRDRAFT_70577">
        <location>
            <begin position="1"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="648" mass="70597" checksum="9DCC5D691CCA4220" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA23</accession>
    <name>F9XA23_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853307.1">
        <property type="nucleotide sequence ID" value="XM_003853259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA23"/>
    <dbReference type="GeneID" id="13399975"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109237"/>
    <dbReference type="eggNOG" id="ENOG502S6QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059426_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA23"/>
    <dbReference type="OMA" id="QWAPNSA"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="37024" checksum="4476B48B5523933C" modified="2011-10-19" version="1">MYQSPTQPGQWPQNPSPANQQPNNQQQQPQQPQQNQPPQQQPPQQWAQQPPQQQQQQQQPPPNGQYQQRPPSQQQQPIGPPPTHPPQQGPVMATLQPNHPDQYRALPSLPPPGQMYAQPYQQAPQMGYPPTQPAPRQRTAIACRYCRRRKIRCSGFDQSDDGRCTNCQRFSQECVFTPVSAQTQAFVPAHTVWRGQNPPANTQLYGAYGQPLPHGGREGYPPQQQQPGQPGQYAPPPQGYQQQQQQPMYGQSPQQGTPMNPDGSRKRGNDEPHTPTLPPPNPAQMGPDGQYRYPDTSGLPDAGPDDKPQFVRNPVRDVGVQVDLITGKDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA39</accession>
    <name>F9XA39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_92766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853294.1">
        <property type="nucleotide sequence ID" value="XM_003853246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA39"/>
    <dbReference type="FunCoup" id="F9XA39">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA39"/>
    <dbReference type="GeneID" id="13399962"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92766"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="InParanoid" id="F9XA39"/>
    <dbReference type="OMA" id="YTMNGWA"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="17620" checksum="5E77AAE4B24E4389" modified="2011-10-19" version="1">MLNACRWAPITDPDPTTCGIPQEYDASKEFAGKKVVLVSVPGAFTPSCSSWHIPPFIARIDELTAKGVDFVVVIASNDSWVMNAWGKVNGVKGDSKIMFMSDTKSVFYKNHGWDAGPGRADRSHRWVMVIERDGTVSVADVEKTTKDVDVTSVDAVLSKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA40</accession>
    <name>F9XA40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_71451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA40"/>
    <dbReference type="FunCoup" id="F9XA40">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA40"/>
    <dbReference type="GeneID" id="13399961"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71451"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.676"/>
    <dbReference type="eggNOG" id="KOG2454">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
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    <dbReference type="OrthoDB" id="310895at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
            <position position="308"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88078.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="609" mass="66085" checksum="26A29360193BF4BD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA82"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80452"/>
    <dbReference type="HOGENOM" id="CLU_2151908_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA82"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="112" mass="12094" checksum="C786861E926898CF" modified="2011-10-19" version="1" fragment="single">PCACPADGGECVCGIMQVPHGGSFNEKDAEKSVNCMIGAGGDALMHAMKTEGLKSDALLLAGKSRMRDVLRRFEKVVGKVKGKGEEMGRFEMDLVNRLMWWNGRGKGFDGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAQ2</accession>
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        <recommendedName>
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    <organism evidence="11 12">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAQ2"/>
    <dbReference type="FunCoup" id="F9XAQ2">
        <property type="interactions" value="829"/>
    </dbReference>
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    <dbReference type="GeneID" id="13397078"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.92"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_0_1_1"/>
    <dbReference type="InParanoid" id="F9XAQ2"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="56027" checksum="ECBB715B3EB5A454" modified="2011-10-19" version="1">MSLVPARNGANGPPTRAANLVTDKPFQTSTKGKVPTGYAEEIAISEQSFRSLHRDVQNRQSAGKKRKREVKGDSAKVYGADAYKGPWAKYEERRIDSDSGEEVEVEISGDESGEEEVVYEEDSILPQPSKGTLAGTSYGEISADKETSTFEGTQQYDYQGRTYMHVPQDLDIDLVADFENLDLKCFHPKKLIHTYRSASNKPAHEKALTALKFFPDSGHLLLSAAADGKVKLWDAYHARELLRTYSGHTKSVVDVDFSPDGTSFITASYDRYMKVWNTETGQCTSRFSTSSTPHVVRWNPSDPSGHEFLAGLHNNKIAQFDTRLPADGDKKNPVQEYDHHLGPVNTITFIDSNRRFITTSDDKSLRAWEYNIPVPIKFIAEPYMFPMVKSASHPSKASVLMQSSDNTIKVYNSGEKIRQNRKKDFRGHNNAGYAIDIDVSPDGGIVTSGDSGGFVCFWDWKTCKMWHKIKASDAAVVSVAWHPRESSKVVTGDLNGVVKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB0</accession>
    <name>F9XBB0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_41684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852707.1">
        <property type="nucleotide sequence ID" value="XM_003852659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB0"/>
    <dbReference type="GeneID" id="13393889"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41684"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.206"/>
    <dbReference type="eggNOG" id="ENOG502S039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039745_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBB0"/>
    <dbReference type="OMA" id="ETFNWIS"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="92"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="329" mass="37221" checksum="F79E1CE41F516EAC" modified="2011-10-19" version="1">MPPQEPILFLWGLSAWASKVTAYFALRGIPYTHCEQPITLPRPDLASLGINYRRIPLLSLGRDIYCDSLLILEKLELQYPAGGAYPSIAATDAKDRALEKLLEKWTDVVVFRSAAAVISTDLDLMKDPGFQKDREELWGRSWSKETQDALRPAALAEMRANWTFLEELLRDGREWVLGNERKGPGLADIHACWIFDWLLMLPGSFPEDYFNEKRFPNVLAWRERYKAAIEKAKEAAPKPTEIEGKECVQKILGSDFNDDDLKVESDDPSGLKEGQQITMAPIDTGYDSADSGKLVGLTNMEAVISTTSKEGGKEMRVHYPRWNFTFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBW4</accession>
    <name>F9XBW4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_58858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852155.1">
        <property type="nucleotide sequence ID" value="XM_003852107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBW4"/>
    <dbReference type="FunCoup" id="F9XBW4">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBW4"/>
    <dbReference type="GeneID" id="13393931"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58858"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.291"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBW4"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26520" checksum="DCC07D3389A8A16F" modified="2011-10-19" version="1">MSQIHAMSDDQVNTELRKMTAFIRQEALEKAREIHLKADEEFSIEKSKLVRSETSRMDTEYEKKFTQAGMSQQITKSTLANKQRLRILSARQELLDSLFEDANKKLADTASKDKKKYEKVLSNLILEGLYALVNEKKVTLKCRKKDDDVVKKAADSAKEEYKKNMKREVDIQLDSDKIPDQSAGGVIILNSTGKIDVNNTFEERLRLLESDALPTVRATLFGENKNRKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC52</accession>
    <name>F9XC52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_42628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852334.1">
        <property type="nucleotide sequence ID" value="XM_003852286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC52"/>
    <dbReference type="FunCoup" id="F9XC52">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC52"/>
    <dbReference type="GeneID" id="13394111"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42628"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.694"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052358_2_0_1"/>
    <dbReference type="InParanoid" id="F9XC52"/>
    <dbReference type="OMA" id="RQYCLKH"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="34395" checksum="BBF28794676B2A4D" modified="2011-10-19" version="1">MAASSRTPDLTSDDSSRRMDTGDVEAIGAHCQMDYCRTLDFLPFRCESCKGKFCSDHRTETAHSCSHAGEWAKRRALANQGPRSSLPFTPKPSILTHEQQCSSPSCKTLINTPLVTGVHCDKCRREYCLKHRFTYDHDCANLIPLGSRPDGQPTQKEKGLAALSKLRAWGAAKKAAMPKPEIPQSRAKQTAAASLAATATLKKTAKGDDKIPVDKRVYLYVEASSDTITAKIPKGNFYYSKEWSVGRVLDAAAKSLQVANVNNRSESEEDKLRVFHVEGGRLLEFGEKLGQSVGTGNTIVLLRGVGPGMAPTPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC95</accession>
    <name>F9XC95_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_72125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852193.1">
        <property type="nucleotide sequence ID" value="XM_003852145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC95"/>
    <dbReference type="FunCoup" id="F9XC95">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC95"/>
    <dbReference type="GeneID" id="13393969"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72125"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.373"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075876_1_0_1"/>
    <dbReference type="InParanoid" id="F9XC95"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="198" mass="21491" checksum="D80CA9601474F7CC" modified="2011-10-19" version="1">MDAAKDNANPTIKNPFDLPSRPTGKDRTKPQGIFDALVPAYPSLADPASPPEVLSDLSDSASEDEREEIDEQEIYDLISTITDPEHPLTLGSLGVVNLDDIKIFPPSSPRSRISSVRVLITPTTTACSLTTVIGLGVKVRLVNALPPRFRIDVRIKEGTSSSADEANKQLGDKERVAAAMENRNLINMVNHMLSSCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCP0</accession>
    <name>F9XCP0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_43124</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851955.1">
        <property type="nucleotide sequence ID" value="XM_003851907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCP0"/>
    <dbReference type="FunCoup" id="F9XCP0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCP0"/>
    <dbReference type="GeneID" id="13393732"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43124"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCP0"/>
    <dbReference type="OMA" id="RTQRWKS"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP86931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="394" mass="42301" checksum="CCD9FD37877B765E" modified="2011-10-19" version="1">METKILAVDARKIGVIKATPNPNDILDGLDLELDTTTVDAQHLQEAAEQLKNSDIPVAFPTETVYGLGADATRSAAVQGIYKAKQRPSDNPLIVHFASLKQLRSLLRGSKTSHQANGLHDTTEDPIPAIYRPLISRFWPGPLTIILPNPENSPLAPEVTAGLSTFGARMPRHVLALALIQMAGVPVAAPSANASTKPSPTAAEHVAYDLDGRIETIIDGGPCDVGVESTVVDGLSSPPVILRPGGLSLDQIRTCPGWEDTQIAYKNKAEAKSQPRAPGMKYRHYSPKAVVILYEAGRSPPSYEELVERVGAHGRLGIVRTESWLSPEGATVELLDISLGRNTGDIARGLFSALRDLDRQDVDAIFVEGIDDNEGDTAAAIMNRLRKAAEIRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDL6</accession>
    <name>F9XDL6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYP-30</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_73230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851807.1">
        <property type="nucleotide sequence ID" value="XM_003851759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDL6"/>
    <dbReference type="GeneID" id="13402171"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73230"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="F9XDL6"/>
    <dbReference type="OMA" id="EMIPGPT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="542" mass="61017" checksum="1C21091F56C97B5C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDR3</accession>
    <name>F9XDR3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_43039</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851779.1">
        <property type="nucleotide sequence ID" value="XM_003851731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDR3"/>
    <dbReference type="STRING" id="336722.F9XDR3"/>
    <dbReference type="GeneID" id="13402143"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43039"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002979_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDR3"/>
    <dbReference type="OMA" id="NDATSWI"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="275"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="812"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="860" mass="96772" checksum="6DF32DB6745677AF" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDR4</accession>
    <name>F9XDR4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_73322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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</entry>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Hane J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    <accession>F9XFA1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="DUF6914"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EGP85619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="179" mass="20387" checksum="2E6C7CB169D73016" modified="2011-10-19" version="1">MPRDKPRLHLALYSRPKHPKSYHYALFISPKKQPATTAIKHHALNTLQQTSQGGLAQPWRYERTEVEIANERRLLALVVVGKVICAQETLDSVLEGIPIYQVDDEDEEAAKSFNCISWAQAAIDKLHRVHAINGLGDWQNIQDLALEYVERKKKQGRWDETSRKGVPTLDLLSGKELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFM5"/>
    <dbReference type="FunCoup" id="F9XFM5">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFM5"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="13397921"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73926"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.282"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="InParanoid" id="F9XFM5"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
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    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
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    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
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    <dbReference type="InterPro" id="IPR001930">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="254"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="545"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP86157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="885" mass="99498" checksum="92DFD3B0FEC9C53E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG69</accession>
    <name>F9XG69_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactose oxidase-like Early set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_12051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85535.1"/>
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        <property type="nucleotide sequence ID" value="XM_003850511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG69"/>
    <dbReference type="STRING" id="336722.F9XG69"/>
    <dbReference type="GeneID" id="13395302"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_12051"/>
    <dbReference type="eggNOG" id="ENOG502SCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2019572at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF68">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="1">
        <location>
            <begin position="380"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="477" mass="49880" checksum="1F5042206BA3867A" modified="2011-10-19" version="1" fragment="single">LGRWGPTIGFPLVPVAGVIEPSSGQLLVWSAYKNDRFLINAENVTQTAIYNPDDGSVKQLPEYVGHDMFCPGISNDFDGNTLVTGGDTSSAASLLQGNSGTWAAKPPMNLGRGYQSSATLSDGRIFTIGGSWSGGFGGKDGEIWDGTKWTLMRGCSVQPMLTNDKQSVYRNDNHAWLFAWSGGTVLQAGPSRNMNWYTMRGSGTVGSAGTRGNDGDAMCGAAVMYDAVAGKILAVGGSPDYQDSAATTNAHVLTIGSVGGTVDVKQVGSMATPRIFANSVVLPDGTVFVVGGQGVGKPFSDDNSAMSPELWDPATEKFITLPIGPTPRNYHSIGLLMRDGTIFSGGGGLCGDCGSANHFDGQIFSPAYLFEADGTTPATRPQIAHLDSTTIQVGSTITVTLASGTNRAATFSLVRLGSTTHTVNTDQRRVPLQASATDADTYSMTLPSDPGVLLPGYWYLFALSNGVPSIATIVKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG90</accession>
    <name>F9XG90_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850771.1">
        <property type="nucleotide sequence ID" value="XM_003850723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG90"/>
    <dbReference type="STRING" id="336722.F9XG90"/>
    <dbReference type="GeneID" id="13397812"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110255"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.500"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036529_1_0_1"/>
    <dbReference type="InParanoid" id="F9XG90"/>
    <dbReference type="OMA" id="VHARWAD"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="293"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="402" mass="44022" checksum="D1ADA2564A7D69F5" modified="2011-10-19" version="1">MDHPERNKRLKSSSGRPISTSDSGASNLPAYQPPQQIIGGARGGSGPGSSRPSASIARPANGAGSLRLTVKAPPSKLRQATSGGSIPPNPYADQSESDDTPAPAPRTARATRNPRTVIDPESDEDEDEDEDEDADGEDLDEDDVNGQLDQQLLGNEDSEEDADGEDDEDMDDHPTPPVIKQQRGTASVRSNITVAPPPSKALKSVEAKEMEDDDDDEELSELESNDDLGNDQDEDNDDEEEDSGSDEDDENSRSATPDLTKLTKRQRAAFEEDPSLMALSNEALKKKHLTDEEHVQRRAEMARRRKNLSEKRNEEEKMETINKLLQKQAPKRRTRAEIAAANAAEHSGEEDEEGRPKPNSLYVRWVSNKDGSRVGVPEEWLHAPVGDVFRRPGGGRLIEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGA5</accession>
    <name>F9XGA5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_110262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850780.1">
        <property type="nucleotide sequence ID" value="XM_003850732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGA5"/>
    <dbReference type="GeneID" id="13397806"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110262"/>
    <dbReference type="eggNOG" id="ENOG502SSN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650866_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGA5"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395631" description="MYND-type domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="422" mass="46650" checksum="EDF9F8D15AEADCD3" modified="2011-10-19" version="1">MKAILLLLAIASIVTAALNTTQAYHLKTELKSVGYGKSQYDNLWISSYHTGAGLSDVVFSDVEGPSSRIGYLGPTNLTANGQQFYNALFDFGNDFPWGLSMAENTNFYAAWQPVRVNAGVSGTQPSVSGFFINETGLQWTTALNAPGTFNDEFGGWIVCDWWHGYPQLFFRIKYYTTPAPASCADVYLKPVSSPKCSQCDKPASSLKRCAKCKSTSYCDRACQTAHWKVHKKICAKLAGSGGDEGPSTGAEVPQRSDSKPFTAIYHNNFLHDRSEEETFKILIDTLRMRQEDMYSFHGDTMPGTIYDGSSTSIPAFRQFIRKAQAVEGFLPPWWTDAKLEQCIRFSKDEGGFSLAGAQEKSDIQETWKDTQMPMKVRMLGERVYGTAPGGRKGDEMLATMVGLECRSAGPQFSTMMDMAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGY5</accession>
    <name>F9XGY5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_100915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849959.1">
        <property type="nucleotide sequence ID" value="XM_003849911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGY5"/>
    <dbReference type="FunCoup" id="F9XGY5">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGY5"/>
    <dbReference type="GeneID" id="13395031"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100915"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_5_0_1"/>
    <dbReference type="InParanoid" id="F9XGY5"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="353"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="708" mass="79129" checksum="C3A106536B5F62DC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH41</accession>
    <name>F9XH41_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_75170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850173.1">
        <property type="nucleotide sequence ID" value="XM_003850125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH41"/>
    <dbReference type="FunCoup" id="F9XH41">
        <property type="interactions" value="1365"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH41"/>
    <dbReference type="GeneID" id="13394449"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75170"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.689"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="InParanoid" id="F9XH41"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="583" mass="61112" checksum="A1EE4E65E81827F3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    <dbReference type="OrthoDB" id="5388486at2759"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
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            <end position="721"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84950.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHG8</accession>
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        <recommendedName>
            <fullName evidence="4">Sec1-like protein</fullName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
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    <dbReference type="OMA" id="VHQLNNA"/>
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    </dbReference>
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        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66905" checksum="311BF0FBEA8F12A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI80</accession>
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            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
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    </protein>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="611"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003932"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85052.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="698" mass="77723" checksum="AFCAF3CCC6492DAA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIJ2</accession>
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        <submittedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_tran_Xtn"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="95"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="406"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="627" mass="69663" checksum="1AE5A2C7C161CFB8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ61</accession>
    <name>F9XJ61_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849797.1">
        <property type="nucleotide sequence ID" value="XM_003849749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ61"/>
    <dbReference type="GeneID" id="13402594"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95588"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.136"/>
    <dbReference type="HOGENOM" id="CLU_542069_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ61"/>
    <dbReference type="OrthoDB" id="10546248at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="603" mass="67494" checksum="C79EB6F0F6151D67" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ73</accession>
    <name>F9XJ73_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgAtr7</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_117820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="protein sequence ID" value="EGP84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849789.1">
        <property type="nucleotide sequence ID" value="XM_003849741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13402586"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117820"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XJ73"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="952"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1578"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1627"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1663"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1783"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="475"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1811" mass="201130" checksum="DE9F77EF4B4AB0F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ84</accession>
    <name>F9XJ84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849327.1">
        <property type="nucleotide sequence ID" value="XM_003849279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ84"/>
    <dbReference type="GeneID" id="13398948"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95609"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.160"/>
    <dbReference type="eggNOG" id="ENOG502RHG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215625_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ84"/>
    <dbReference type="OrthoDB" id="3650064at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="26105" checksum="7853D2923230FC55" modified="2011-10-19" version="1">MAEYEDKLFVRLREMPQELFDQIEAYVKTPDPPSGRMINIDNTYTPPPFLQLNEYSRRKSASTYYSTNTFSFTDLQVCWKWLEALKKEHVEQIKTLRFYPSRHPTAQLLRLDAQEAERAVKAALLSAHGKLKAGLQVWQPDDSEDRDKWFFEDKWFVFELVRAPPILSGGVPGSWWTPIIGASQVHALGGHTLAGLPTIPMPPFPSSLIGGQTSWEQSWAVPTEHMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJK3</accession>
    <name>F9XJK3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_117758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849468.1">
        <property type="nucleotide sequence ID" value="XM_003849420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJK3"/>
    <dbReference type="GeneID" id="13402263"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117758"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XJK3"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="511" mass="54612" checksum="54D397D897EA2A98" modified="2011-10-19" version="1" fragment="single">IGLFLSFIDSSIVSTAIFTIGTEFNAATRVFWVASAYTLANVAFALPFTAVADVIGRFRAYLLASVVYLVFSIACGFAQTLNQLVAFRALQGLGGSGLYALGQVIWPEMMTISQRRWLGAAIGGILAIAGAVGPLLGGAITSGATWRWIFWFKTPVAAVALMLFLVSWPRQARHHVRRAIRTLDWVGCLLLIGASTLPTLAFQEAGRKPISHEALFLAPLIIGICLWIVLVGWEIYIAKSERCSWKTVPIFPPDLMRTRRYTAAAINTLFTGFAYYIVVYAIPLRLQGVNGRTPVQAGIALVPLLGAAAVGSFSTGGLSFKKDMLGWTSIAGSALMAIGTGLLTTLEVHDTRAIPKSLYGFEVFAGLGFGLAVASASMLANFECELEHHAVAQGIVSQARVLGGSLGIAAASAILGRELRIQASIAVRESKDASLSGTASDELSKSVQIAYSDAFSTTLLVACVVCCVAFFSALGTWDRHKQGLRERNAAQEQRESDRIERLTAPTRVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJS9</accession>
    <name>F9XJS9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_82033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849845.1">
        <property type="nucleotide sequence ID" value="XM_003849797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJS9"/>
    <dbReference type="STRING" id="336722.F9XJS9"/>
    <dbReference type="GeneID" id="13398901"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82033"/>
    <dbReference type="HOGENOM" id="CLU_2308306_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJS9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="10159" checksum="337886D6F451DDF5" modified="2011-10-19" version="1">MRTQSRRVSGNFVPGKRTSGNFSGARIFATGDGAGRTVSGGGSGNVQGRAVSGGSEGLGLTGVGRGAGEVTNFALPRTPPPAVERVDEEEVLLQGREGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJX9</accession>
    <name>F9XJX9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_16557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849741.1">
        <property type="nucleotide sequence ID" value="XM_003849693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJX9"/>
    <dbReference type="STRING" id="336722.F9XJX9"/>
    <dbReference type="GeneID" id="13402538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_16557"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="InParanoid" id="F9XJX9"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="285" mass="30255" checksum="2BFEF684069C1542" modified="2011-10-19" version="1" fragment="single">DRRRINAPPGGTAPPVFATPPDLNLSRPTRTRQPDEHRKIFLRTGVVPSASGSAYYEIPPETPSTSNDILVPSSSSLKITCTVHGPRPLPRNAAFSPNMLLTTHVKFAPFATRQRRGYVRDASERDLGVHLETALRGVIIGERWPKSGCEVVITVLEGEEDGWWGEAGKGGKGGGWGMMNVLAGCITVASAALADAGIDCVDLVSGGVAALTGDGKEGFVLDPSPSEHDIRAACVVGYLQSRDEITELWLKGDSGAQSEMLMDQAVKAATLTRTVLAEAVKEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK06</accession>
    <name>F9XK06_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_101204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849729.1">
        <property type="nucleotide sequence ID" value="XM_003849681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK06"/>
    <dbReference type="FunCoup" id="F9XK06">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK06"/>
    <dbReference type="GeneID" id="13399083"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101204"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK06"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="705"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109298" checksum="C80334899F3FB887" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKW9</accession>
    <name>F9XKW9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_48544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848999.1">
        <property type="nucleotide sequence ID" value="XM_003848951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKW9"/>
    <dbReference type="GeneID" id="13398325"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48544"/>
    <dbReference type="HOGENOM" id="CLU_2910618_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKW9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="6981" checksum="90E189E679C59F77" modified="2011-10-19" version="1" fragment="single">EAIRYLFGNMRALTDLVIRHFSLVRGDNTRNADLVDLTGYPLPNEGPYDCVILVFGLARTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL47</accession>
    <name>F9XL47_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848878.1">
        <property type="nucleotide sequence ID" value="XM_003848830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL47"/>
    <dbReference type="STRING" id="336722.F9XL47"/>
    <dbReference type="GeneID" id="13398048"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96232"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.289"/>
    <dbReference type="eggNOG" id="ENOG502SZQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641251_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL47"/>
    <dbReference type="OMA" id="WLSHETA"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="428" mass="48186" checksum="48CFC753254E68C5" modified="2011-10-19" version="1">MEHKLAAGLEHIRSSIEIVQNADFGLGQMARTCISRRSPRSSRSIRLPCRVNTHITAIMSAPSPYQQIICNAEFLVKAGFSRPAAEEMFTKWQFLREKYPEFCPGLEMHAIECLDDQFGQWGSHRSADACGPNDDYGAAWLAMGVEPSLLPRLLAEEHRPIRLLTSASDALRESIRATHDHMWGLSTFEREAAKRQHQAQIQTEVDLPAAKKGHTMLYKAGTVFNLEEVWSGNETMPLSLGMLADKPPTDFDRLRYGMVPTLAQLEIAELQCSYKASFARHVPFGIVHIAVPDHLLTQQSNFLHIDDPAHRQKMVWQCRGPWKKPPSLWEGLSEDVAHYTNREQVGVAGSICAQSTELLNQLSNETQVRPLKLANGEEAKQYVALPASYNDLNDECEGLVWLEERRLTEDGIRLMPSSGKAMTRAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLC4</accession>
    <name>F9XLC4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_62954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848805.1">
        <property type="nucleotide sequence ID" value="XM_003848757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLC4"/>
    <dbReference type="FunCoup" id="F9XLC4">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLC4"/>
    <dbReference type="GeneID" id="13396638"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62954"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="InParanoid" id="F9XLC4"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="159" mass="17695" checksum="E50AB145AA93F75E" modified="2011-10-19" version="1" fragment="single">MVFRALGRSTLYFIGSASTLIMLNDNFVEITVINGSSMSPTLSPDFATTAARDLVLWNKAYPTRRLRRGDVVLFASSTDPEETVVKRVVALPGDLNPAARRWDIMYDQGRGKVQIPQGHLWVEGDNWRMTRDSHMYGPVSRALVKGKAVGILWPAGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLI6</accession>
    <name>F9XLI6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_82439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849082.1">
        <property type="nucleotide sequence ID" value="XM_003849034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLI6"/>
    <dbReference type="FunCoup" id="F9XLI6">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLI6"/>
    <dbReference type="GeneID" id="13398479"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82439"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.381"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLI6"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8368" checksum="158758D8A6725377" modified="2011-10-19" version="1">MAFAWKAAGITYNRYLAVASRVVRRSLKEEQRLKAEKRGEIDLRFAKWENGKQQELRSVETANAEAAQQNASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLM5</accession>
    <name>F9XLM5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848829.1">
        <property type="nucleotide sequence ID" value="XM_003848781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLM5"/>
    <dbReference type="GeneID" id="13398637"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96157"/>
    <dbReference type="eggNOG" id="ENOG502RMBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2265843_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLM5"/>
    <dbReference type="OMA" id="HHEAYLS"/>
    <dbReference type="OrthoDB" id="3643646at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="103" mass="11227" checksum="0706E36D921FEF96" modified="2011-10-19" version="1">MSLGSAMYDYQRGGTTKPSEIHSSASHDHHSSANDAQKPPLQRNTTNHYEQAVAAAGQTAAGSGTEERPALDRQQSWKMSDLKREHAEKMLSVEPKGQGYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLS8</accession>
    <name>F9XLS8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_101478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849060.1">
        <property type="nucleotide sequence ID" value="XM_003849012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLS8"/>
    <dbReference type="FunCoup" id="F9XLS8">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLS8"/>
    <dbReference type="GeneID" id="13398184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101478"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.423"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050888_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLS8"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="41071" checksum="DA9F93B287AA3618" modified="2011-10-19" version="1">MASDEIVWSIINNQFCSFKLKLPGNQSHQKSTKQTFCRNEHNVTGLCNRQSCPLANSRYATIRSDPATGRLYLYIKTVERAHLPSKWWEKIRLSGNYAKALEQVDERLIYWPKFLVHKCKQRLTRLTQVRVRAAKLAKEEERLGERMVSKQAPKIRRREATRERKAEAAAKIERAIERELVERLRSGAYGDRPLNVEEGVWKKVMRGLERSAEGLRDEDLDEGIEEEYEYENEEGIAEEEDGNVEYVSDMEESDDEDDMEDFDDWLGGQSGDEQAAGEDSDADSAAEGEEDGSGDDDGEDADDDTAALKKKLDTLKRKRPAAPAAPKPRKKPTKKGKGPKTNIEYEYVPEPAQREMLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLT7</accession>
    <name>F9XLT7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_31040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849054.1">
        <property type="nucleotide sequence ID" value="XM_003849006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLT7"/>
    <dbReference type="STRING" id="336722.F9XLT7"/>
    <dbReference type="GeneID" id="13398451"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31040"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127296_2_0_1"/>
    <dbReference type="InParanoid" id="F9XLT7"/>
    <dbReference type="OMA" id="HYSEVEX"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="70" mass="7919" checksum="538693B2D176BF87" modified="2011-10-19" version="1" fragment="single">GEINWDCPCLGGMAHGPCGEQFRAAFSCFVYSKEEPKGVECIEHFKTMQNCFREHPEIYGSELDDDEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XME9</accession>
    <name>F9XME9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_76618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848736.1">
        <property type="nucleotide sequence ID" value="XM_003848688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XME9"/>
    <dbReference type="FunCoup" id="F9XME9">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XME9"/>
    <dbReference type="GeneID" id="13396352"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76618"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.14"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="InParanoid" id="F9XME9"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="213" mass="21707" checksum="A085D0CE017EE41F" modified="2011-10-19" version="1">MSFRGGSRGGFGGGDRGGRGGGGFRGGSRGGRGGFQQSYGPPDTVYEMGSFLHATEGELVCESINVKIPYFNAPIYLENKTPIGKVDEILGPLNQVFFTIKPQEGIQATSFKSGDKFYIGGDKLLPLEKFLPKPKPPPGAPKVKKPRGAGGFGRGAPRGGARGGRGAPRGGRGAPRGGGRGGFSGGRGGGGFSGSGGFSRGRGTPRGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMG7</accession>
    <name>F9XMG7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848728.1">
        <property type="nucleotide sequence ID" value="XM_003848680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMG7"/>
    <dbReference type="STRING" id="336722.F9XMG7"/>
    <dbReference type="GeneID" id="13396356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111160"/>
    <dbReference type="eggNOG" id="ENOG502SR3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315728_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMG7"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="925" mass="100980" checksum="8858DD2534E82628" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMZ2</accession>
    <name>F9XMZ2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MgAtr4</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_117799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848348.1">
        <property type="nucleotide sequence ID" value="XM_003848300.2"/>
    </dbReference>
    <dbReference type="GeneID" id="13396392"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117799"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.221"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XMZ2"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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</entry>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="196" mass="21578" checksum="9C290A5FD762485E" modified="2011-10-19" version="1" fragment="single">MSLDAFMSSLRIRKPFLAAFGFLVGASAYLGLSTQKLPQYGQSDKGLHLVTFFLLTITFYWILETSRRRCINLSLLVCTAGLGIGSEVVQGLLPNGRDFDPYDILANVVGSGLALGLSSWYHRRMLERKRKNKHYDIVPGEELGDEDHAAERDVELGVVGDQETGVVHGDSQAGAGAGKTVTEELDNWDENAEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN57</accession>
    <name>F9XN57_ZYMTI</name>
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        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_63697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848596.1">
        <property type="nucleotide sequence ID" value="XM_003848548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN57"/>
    <dbReference type="FunCoup" id="F9XN57">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN57"/>
    <dbReference type="GeneID" id="13396510"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63697"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008978_2_3_1"/>
    <dbReference type="InParanoid" id="F9XN57"/>
    <dbReference type="OMA" id="DCRSRFF"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="504" mass="56178" checksum="0DEF8056D0F85C18" modified="2011-10-19" version="1" fragment="single">MGIQGLLPLLKSIQKPTHLRNFAGQTLGVDAYGWLHRGTVACAIELAEGKPTRKHIDFALHRVRMLIHFGVTPYIVFDGDYLPSKSHTEKERAARRKESKRVGLELLRMGRTSQAHLELQKAVDVTPVMARELIEELKRMDVPYVVAPFEADSQLAYLEQQGKISGVLSEDSDLLVFGVKCLLTKLDQYGECIMVNRADFTSCRDISLVGWADKEFRIMAMLSGCDYLPGIDKMGLKTAYRYVRKHKTVERIVQAVQFEGKMKVPPGYLEAFLNAERTFLHQWVFCSDTRGLLNLTPLPSGVDAESMPYIGKTVDAELAAGVACGDLDPNTKLPIVLPQRFQNRFQNPASRSTLIQTPDEKHGKPISDFFKARRTPLAELDPNSFTLSPSQQQTSESQRNASWSASQAPSSRVFGGRRASQIPVPSSAPQVTRRVATAPTPLARLTSPKRQRLCSDSSALAAVMNPVETAASRFFAQQPTQPSPSMRTKSNRSKKEEFDLWSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN63</accession>
    <name>F9XN63_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848381.1">
        <property type="nucleotide sequence ID" value="XM_003848333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN63"/>
    <dbReference type="STRING" id="336722.F9XN63"/>
    <dbReference type="GeneID" id="13396269"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106138"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.298"/>
    <dbReference type="eggNOG" id="ENOG502S71Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="InParanoid" id="F9XN63"/>
    <dbReference type="OMA" id="LKHWPTD"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cbp6"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="112" mass="13082" checksum="FF83475FD10C211B" modified="2011-10-19" version="1">MSRQKTVAHYTRILSQWPADVLRPERTFADGVLKPRLSKPPATFRSEDKEINAAYLLIGDAFRKQYPLPASLMKPASQPEFYDNLARELKELPSRSMFGAWVKRMKNMIRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XND7</accession>
    <name>F9XND7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="13">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_106186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848557.1">
        <property type="nucleotide sequence ID" value="XM_003848509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XND7"/>
    <dbReference type="FunCoup" id="F9XND7">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XND7"/>
    <dbReference type="GeneID" id="13396176"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106186"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.378"/>
    <dbReference type="eggNOG" id="KOG4697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081382_0_0_1"/>
    <dbReference type="InParanoid" id="F9XND7"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23144" checksum="0041DE64C8DD8F01" modified="2011-10-19" version="1">MARRRRPPRPGALMDLSPVRIATQILLLQLSYYGVAIVLIVFTTFVAGEHPDPTRFFDWRQLRGDVTTGWTLGLCWMLDALITVIPILLLIARSKLVPDFALTIHGLNFIITSLYTREIPNTFAWWLLQICSATLMIGVGIWACQWRELRPMAFGGRSKEQTATNSAGNGHLPGPQDEEAGFEMGSSSRGAGRDGAGSYEMVGVAPKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNL2</accession>
    <name>F9XNL2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847916.1">
        <property type="nucleotide sequence ID" value="XM_003847868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNL2"/>
    <dbReference type="GeneID" id="13401674"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106324"/>
    <dbReference type="HOGENOM" id="CLU_3015971_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNL2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="56" mass="6072" checksum="A4DDFF9D73A342DE" modified="2011-10-19" version="1">MDSSNSRCSIADELNAKQPESHGIDGPLPFGASAGIENWEPSTKFHVPPRHVTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNP2</accession>
    <name>F9XNP2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847931.1">
        <property type="nucleotide sequence ID" value="XM_003847883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNP2"/>
    <dbReference type="GeneID" id="13401804"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97031"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.193"/>
    <dbReference type="HOGENOM" id="CLU_2075008_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNP2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395584" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12734" checksum="B5B9E636894692A9" modified="2011-10-19" version="1">MHLSAFLATVLGFQLIPTMVLAKDNPHQHCQCIYRDTGLVDERATALGCDDLDHANMHGGGASPNCAAEDFWGIRNDCWQCKCDQYVSNGRALGSNCWNADGGRINIHCGGVPNPDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNQ2</accession>
    <name>F9XNQ2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_77404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847936.1">
        <property type="nucleotide sequence ID" value="XM_003847888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNQ2"/>
    <dbReference type="GeneID" id="13401654"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77404"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNQ2"/>
    <dbReference type="OMA" id="FHAWKTH"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="934" mass="104611" checksum="8661D0CF557EB18B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP51</accession>
    <name>F9XP51_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_50840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848012.1">
        <property type="nucleotide sequence ID" value="XM_003847964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP51"/>
    <dbReference type="STRING" id="336722.F9XP51"/>
    <dbReference type="GeneID" id="13402075"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50840"/>
    <dbReference type="eggNOG" id="KOG2926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_5_0_1"/>
    <dbReference type="InParanoid" id="F9XP51"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000006">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="49"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="407" mass="44104" checksum="1A0F43B77A32305F" modified="2011-10-19" version="1">MATPTKASTTAHRTLLSLPASLRPTILVSAQARHQSTIQPKKHPKTAIFFPGQGVQRVGMTTDWLEAFPRTVKPILDQVDETLGVSLSKIIAEGPNANLMATENAQPAIMATSIIILRVLEQEFGFNLADRIDVTLGHSLGEFAALVAGGYLREADALKLVRRRAEVMAKCSKDTGEEVGMVALVCESDHLTPMVEAIHSFLGHHSEGSKSDSHSDSDLPAVQQVLIANVNSKNQIVLSGSIKRINELLTHLRQFGGHDPRAVRLKSDSPFHSPLMKPATEMLKKMLDQPSPTVPGSDIIMWPGVVPCISNVSARPFESKQNLKDLLARQCVETVLWHDSIVYLHQDVGVKRWVGIGPGKVGRNLVGKEVGMKGIGKGGGVWGIGGPREVEGILRDLDATEHLEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP62</accession>
    <name>F9XP62_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_106407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848017.1">
        <property type="nucleotide sequence ID" value="XM_003847969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP62"/>
    <dbReference type="FunCoup" id="F9XP62">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP62"/>
    <dbReference type="GeneID" id="13396055"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106407"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.377"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="InParanoid" id="F9XP62"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14325" checksum="84D4464F51D7904C" modified="2011-10-19" version="1">MSTKAQGKKPAGKTGRSAIEDVVAREYTIHLHKRVHGVSFKKRAPRAIKEIRAFAEKAMGTSDVRLDPQLNKKVWESGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKNPKGLQTAVVEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP84</accession>
    <name>F9XP84_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_111559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848028.1">
        <property type="nucleotide sequence ID" value="XM_003847980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP84"/>
    <dbReference type="FunCoup" id="F9XP84">
        <property type="interactions" value="1110"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP84"/>
    <dbReference type="GeneID" id="13402084"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111559"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="InParanoid" id="F9XP84"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="155"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="424"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122633" checksum="D684A7EA719875C6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPD3</accession>
    <name>F9XPD3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847848.1">
        <property type="nucleotide sequence ID" value="XM_003847800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPD3"/>
    <dbReference type="GeneID" id="13401488"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106248"/>
    <dbReference type="HOGENOM" id="CLU_2298539_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPD3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="101" mass="11279" checksum="65D2EAEAFDB39C7D" modified="2011-10-19" version="1" fragment="single">NIEGVRLTTNVGKSRCTAPSWSTRKSSFDGRRREFRSCRSAWSRSSTNRAGTAYRNTSTPTPAKSDQAGQSQSLTRYDVRYLLHAVLSLYVCGDRLALKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM8</accession>
    <name>F9XPM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_111586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847825.1">
        <property type="nucleotide sequence ID" value="XM_003847777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM8"/>
    <dbReference type="GeneID" id="13401464"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111586"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="F9XPM8"/>
    <dbReference type="OMA" id="LGMSWSV"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="62"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="443" mass="47307" checksum="5255B0CBA766CB9A" modified="2011-10-19" version="1">MEKNDSTTLVDERQDHDSIPGSEKSDTFAKTDEDKQAVEMITPAEAHAPTTAAPPMKDGGTRAWLQVAGSFLVFGNLWGMSFAFGSFQSFYETSYLPTLPASTISWIGTVTIFLLILIGVISGPLFDLGYFRTMLITGALIETLSVFLVSVSSSYYQLMLTQGVLMGLGNGLLYLPGLALVSRSFKRNRAIAMGITTCGAPIGGIIYTLVFEQLISRTSFGWTVRAMGFIMLGTYLLSFPLLLFRATNLGDLAAGGAPRKLFDKTALRDAPFWAYAWSNFFIFCGYMVPFIFIPSYAQQNLGTSRSFSLYISIIAQATSIVGRLVAGLSAAKIGGMIPWVVCVVSSGALCLGWIGATSVGSFVTFAALYGAFSGALIPLPPSVFPQVCPDPKVFGARLGMAQGIGSVASLIGPPIAAALAEVWTLGAVRRGMKYLGTRQCIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ45</accession>
    <name>F9XQ45_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_51173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="324"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="76"/>
        </location>
    </feature>
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            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="363" mass="43157" checksum="EE4CF700630D1A50" modified="2011-10-19" version="1">MRLRSHGRVPSTPRRRDGGIRKEHPTPKRSQAIILHQIAVPRHEIFDLTDIPRRTQQYQKSKGLSERRMKTRRGAQRAISTRTLRKIIAWVSESFEHRTVKWQELKDHFHLGCNERTLRNTMHAAGYHKCKACQKSYLRAANVDKRKAFCATRLFLTLDYWKSVRFTDEVHFCVEARRAAMVIRNHEERECETCIQFNKRNTTSVFHCWAMVGWDFKSELVFYNKGGNLTQQQYLYRIFKPHIEPVWRQHVADQLPFILEEDNDGSHGTRSTDNDVHRYKMSLQGFLWYANSPQSPDLSVIENVWRILKQRVKSREPTTKDELRCYIIEEWANITQDEINKLVLTMPQRIHDCFYNDGLHTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111693"/>
    <dbReference type="eggNOG" id="ENOG502S3WY">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="FVWTATR"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="TreeGrafter"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003391658" evidence="2">
        <location>
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            <end position="451"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="451" mass="48157" checksum="763A8F60ED4C53B5" modified="2011-10-19" version="1">MASKRTLSMLIFLLRWFLSYFDLTALVSCSATTTAPTIPSTTSTTDPINTTMHLTALLGLCASTASAINLYVSDYAGNVTTLEFLQESSGNYSLKPTYVNPGCAPNPSWLTLDSHSRLLFCANEGLSSANGSLTTFTINSNGSLTSLSNTTTLSGPVSAVVYGDTHDKAIALAHYSGSAVSSYLLRDSKPAFSHQFPFTLPHPGVDPERQDAPHAHEVLTDPTGQYLLSPDLGSDLIHVFAINPESLALTPCKSIPATPGSGPRHGVFYNPTGFPNAGGKTYFYLVEELSGHISSYEVSYLPNQGGLSFTGPLQSENATWLFNVPGRNAPAEIEISPDNRFLIVSNRNSTAFTLPTIGDSDSISTWALDPKTGAFNFLQLWPSSGAFPRHFSISKTGQFVAVGLQSIQTVAILQRDVATGLIGEPVARVEVSGNVTAVVWDDEWTGMGWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM2</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="F9XQM2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="519" mass="58670" checksum="AAD1D0C5AC69E08F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRK8</accession>
    <name>F9XRK8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847135.1">
        <property type="nucleotide sequence ID" value="XM_003847087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRK8"/>
    <dbReference type="GeneID" id="13399639"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97854"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_18.6"/>
    <dbReference type="HOGENOM" id="CLU_1009034_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRK8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="276" mass="30018" checksum="4EB438CE7D14E399" modified="2011-10-19" version="1">MPSKSNQPNQDVLRVCIIIIIIVASSILASTFEAAANLLGHQAEAGPSLVVEIPEQVDVGADSTEMNVSEESLQEDVSEESKQEDVSEESEQEDVSEESEQEGVSEESEQEGVSEESEQEDADGTIVAEKLVIPQKTFAIPTTKVHSKPAIPATKVHSKPAIPAIKVHSKLTTPVIPSDLFATVVADPVFMNWCMDPTTTALTPDRARDFPHVANHPLQSELKAKHHNEMAAVDKTSTKKKTHKPIVVAVGKKNKVRFFSLSPSRSVDRGRTSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS23</accession>
    <name>F9XS23_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846918.1">
        <property type="nucleotide sequence ID" value="XM_003846870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS23"/>
    <dbReference type="GeneID" id="13396706"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98012"/>
    <dbReference type="HOGENOM" id="CLU_729994_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS23"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="379" mass="43481" checksum="ED433F8F44607205" modified="2011-10-19" version="1">MGAGKQGQTPQEETTKDLNDEAFRRVTHINIEHPNDLRLLSTPRTVPLTWRGPLLLRRRIILATNRLYRRSIRLRPNAGDWVHKLDRIDNYTILPDRCWMLCLRFRARAESPVTASASAEGRNPGPHPTLCAIAISTVPVPIHGRARSDPKYYSSGSRSMVGKMSASDRWCPDMVIIISSMGSKRCGDCMEDMHGGYELRRHFRPKERIWRMCSADGTNRPEVLLYSTFVDAMRGLVSRMFAEDSTYRNLVFLLLLNSVLLQPFNKRAWLQPRKVREWSEDSPLRDPCLCVLWRTFRFLTFTSTFTSTARFKAKLNAPTNFTEGRIILQRCSIGCARDGLENEVEMRQMPINGQEKGRAATQVGVHYWAAMPTRHMIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS38</accession>
    <name>F9XS38_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846969.1">
        <property type="nucleotide sequence ID" value="XM_003846921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS38"/>
    <dbReference type="GeneID" id="13396712"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98027"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_20.40"/>
    <dbReference type="HOGENOM" id="CLU_869331_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS38"/>
    <dbReference type="OMA" id="NENNEYM"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="320" mass="36165" checksum="85D89B35F3AEEA6C" modified="2011-10-19" version="1">MATVYHNFRSFETESLAGVANGAPLASSPAHRSSHWSTTVPPLRAPNSLHLLQAATISSPSEHHRHRQQYAAWHRALADHEQTLETRGSQILADREACDAEITQSRALARSIQDLRGRMTAEMQELETWQLQLEHQQEGLTKDKARIKKEKDRLAHERMALDAWDEAVETRVEVVQRREGELQTWQEELEASETVMRREIAAWQEKAAKIEQDGRNLGQLVQCADGDRGGNQSSGSSKKSSVGEWEAMEGEHSTLDQEMAAHEMSPSEASSHAPSLTLVILGREASQEEEEEEEEQDQEEDPRKRRGRPLHNICKISCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW56</accession>
    <name>F9WW56_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857672.1">
        <property type="nucleotide sequence ID" value="XM_003857624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW56"/>
    <dbReference type="GeneID" id="13403243"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98224"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_1_0_1"/>
    <dbReference type="InParanoid" id="F9WW56"/>
    <dbReference type="OMA" id="VQDCGHG"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390959" description="Het-C-domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="896"/>
        </location>
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    </evidence>
    <sequence length="896" mass="98620" checksum="81B81436BB1D4F6F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92789.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">CBS 115943 / IPO323</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="nucleotide sequence ID" value="XM_003857745.1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88617"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336846_0_0_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="10"/>
            <end position="99"/>
        </location>
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        </location>
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            <end position="194"/>
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        </location>
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        <source>
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    <sequence length="846" mass="91612" checksum="4F42675C3CA23BD9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXK6</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003856187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXX0"/>
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    <dbReference type="GeneID" id="13394640"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89301"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.870"/>
    <dbReference type="eggNOG" id="ENOG502QQZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457986_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXX0"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WGR_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="3">
        <location>
            <begin position="207"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="596" mass="66079" checksum="FD78264F4E1BF507" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYE9</accession>
    <name>F9WYE9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_32909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYE9"/>
    <dbReference type="GeneID" id="13395420"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32909"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="F9WYE9"/>
    <dbReference type="OMA" id="TRWDHWL"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="55666" checksum="77B44DC2562386D4" modified="2011-10-19" version="1">MRSKTDDDSVWQSMKKYKRVGVVAMSAAFAASLDGYQITLNGGIVSNKGFIRQFATPGTKIIAGKYISAWGGIQSAGQALGQIGLQFVADAFGRKVALLTLWVFLVASIFAETFATRWEHWLVAKLFSGMGVGMLQSTVPVYLSEVAPTQLRGFFINAYTFWFVVGQLFGSVALKSLRDSDPYDFRTAIYTQWAMVGTMGTIFFLLPETPWWLVQKGRSSDAAKILRKYNGHIDGYRVQESIDIMNNTIEEERHLAKRDSQEGFFSVFQGQNLIRFVIAAWPKITQQLVGLTVFNTYATYFFQYAGNKDPFLVTVILSCCQILSMMVTCSLTDTIGRRPLTIYPYGVTVLSVLSIGIIGCFDYKAQATGSLLVFFGCMATFATTGASAIGYAYAAEVPQQRLRARTAAFGLAASNCIAIMFNFCTPLMINGTNKWGVKTGFFFAGTGALAVAISWYILPELARRTPAEIDEMFEKKVTLRKFKRYVTDVQMNVEEPSKLEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYU8</accession>
    <name>F9WYU8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_65316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856023.1">
        <property type="nucleotide sequence ID" value="XM_003855975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYU8"/>
    <dbReference type="FunCoup" id="F9WYU8">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYU8"/>
    <dbReference type="GeneID" id="13403202"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65316"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.410"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_1_1"/>
    <dbReference type="InParanoid" id="F9WYU8"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="20710" checksum="6B6D4C1D08B09A3D" modified="2011-10-19" version="1">MTTTSGKTCFVTIGATASFVGLIKAALAPDFLAALKSHGYTHLLVQYGQDGKALFDSCIGSLDQIDIHISGFDLDKAGLAEYMLQAKGERNTGRQEGVVVSHAGSGTILDALRISVPIIVVPNSELLDNHQVELAEALAEQEYVVHGSLHALGQALNEAAQLGKKSKSWPPPNSGFHREARGLKGVLDDEMGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY2</accession>
    <name>F9WYY2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_65364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857615.1">
        <property type="nucleotide sequence ID" value="XM_003857567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYY2"/>
    <dbReference type="GeneID" id="13403186"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65364"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.442"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="F9WYY2"/>
    <dbReference type="OMA" id="NAIMVPS"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP92591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="559" mass="61057" checksum="266B2347EA5B5628" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZB8</accession>
    <name>F9WZB8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_30903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857255.1">
        <property type="nucleotide sequence ID" value="XM_003857207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZB8"/>
    <dbReference type="STRING" id="336722.F9WZB8"/>
    <dbReference type="GeneID" id="13402826"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30903"/>
    <dbReference type="eggNOG" id="KOG4487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090690_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZB8"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="95" mass="10295" checksum="0C05A18761324E69" modified="2011-10-19" version="1" fragment="single">RSEPSSNTAVDNPLPQLLETPSGLAIVELQGSVLSEEQESGAVQALSLGRLVFPAAEHGENSDWDGKRVFLFIGKHQRMAGEVKKLSKPVAVMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZF7</accession>
    <name>F9WZF7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_14095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855849.1">
        <property type="nucleotide sequence ID" value="XM_003855801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZF7"/>
    <dbReference type="FunCoup" id="F9WZF7">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZF7"/>
    <dbReference type="GeneID" id="13403771"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_14095"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZF7"/>
    <dbReference type="OMA" id="QFCAGEK"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="76"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="403" mass="44484" checksum="6B8336BA93CE3D38" modified="2011-10-19" version="1" fragment="single">SILATLPLSHILRTYLITAMSSSPILLQSSTSILRRMLESKNPLFRLDSNPIMRAVLLETFYKQFCAGTNAAEIAKSTADLRQLGYSGVILEYAKEVLKDAESNELAEIAEWKTGMLKSIEMAAPGDLLGLKWSGMGPAAMNRMKDQLPPSKEMDEAMHSVCKAAAEKDMALLPAAEETWNLAGFHDWCLNLQRVYNTSGKAVVYTTYQLYLKQCPATIAEHLALAKKEGFTLGAKLVRGAYLATEKRELIWPDIQTTHNAYDAAMTALIKRQYTSSIPQPPGAPADYPSLNVVIASHNAATVTLAQKLRQEQAARGETLTPLIFAQLQGMADEVSCQLLAAAKQSKEEGTMPVERVFKCTTWGPMYECLNYLLRRAAENKDAASRTGDTRKAMGVELMRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZQ9</accession>
    <name>F9WZQ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_33257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857689.1">
        <property type="nucleotide sequence ID" value="XM_003857641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZQ9"/>
    <dbReference type="FunCoup" id="F9WZQ9">
        <property type="interactions" value="1095"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZQ9"/>
    <dbReference type="GeneID" id="13403899"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33257"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.277"/>
    <dbReference type="eggNOG" id="KOG1251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="InParanoid" id="F9WZQ9"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="62"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="403" mass="42599" checksum="AD2D3E5A8C68B156" modified="2011-10-19" version="1">MADLSTCPPLTRSSVQIAHKRIQSYIHLTPTSTCETINHIASTAQASRTDSQPAGDVSSCTANPKVKLFFKCENQQRIGAFKARGAFYALGRLIEEEGLEEVKKKGVVTHSSGNHAQALALAARTHGVPAHIVMPGISTPSKIAGTQAQGANVIFSGSTSDEREAVVAELIEKTGARLVPPYDHPDIMLGQGTQALELESQAEELIAQNPGLGVKGKRRLDAVIAPIGGGGMLSGICTALQGTGIKVFGAEPNFEGANDAEIGLKEGKRVEKVKTLTIADGLRTPVGVHPWGVITDKKQLEGIYSVSEEQIKAALKLAMERAKLFIEPSAAVPLAVMLYNEEFRKLVEKEAGEEGWNVGIILSGGNTTVEAIAKLFAAPAKVEERAEGKVGINGERTAENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X036</accession>
    <name>F9X036_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856301.1">
        <property type="nucleotide sequence ID" value="XM_003856253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X036"/>
    <dbReference type="STRING" id="336722.F9X036"/>
    <dbReference type="GeneID" id="13402934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107221"/>
    <dbReference type="eggNOG" id="ENOG502RGD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382711_0_0_1"/>
    <dbReference type="InParanoid" id="F9X036"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="219"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="723" mass="78894" checksum="9F9B9F6049299850" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0M3</accession>
    <name>F9X0M3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_67239</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857009.1">
        <property type="nucleotide sequence ID" value="XM_003856961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0M3"/>
    <dbReference type="FunCoup" id="F9X0M3">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0M3"/>
    <dbReference type="GeneID" id="13398720"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67239"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1762"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026967_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0M3"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
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    </dbReference>
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        <property type="entry name" value="PMI_typeI_cat"/>
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    </dbReference>
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        <property type="entry name" value="PMI_typeI_hel"/>
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    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
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    </dbReference>
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        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PMI_I_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="356"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011956"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP91985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="452" mass="48962" checksum="C5DEFE0955F6A652" modified="2011-10-19" version="1">MQVPLLRLQCGCNSYEWGKVGKDSAAARFAAATPSDDFSIQDDKPYAELWMGTHPSNPSKDLATGRTLLDLVQDNQALLSPAIASRYAQKLPFLFKVLSINKALSIQAHPNKSLAEKLHASDPKHYPDDNHKPEMTIAVTDFDGLCGFRPLNEIAHFLQTIPSLRELVGEEASSSFEKTIKGQETTADDSKTKENKKALQTAFTNLMNAKPDAISSAAPKLIQQAKDEGAKFAGSGGPSNDGQELADLMVRLDGQFPNDIGLFVSFFLNYVKLQVGEAMFLKADDIHAYLSGDIIECMASSDNVIRAGFTPKFKDIPTLTSSLTYSYAPISEQKMSPSPYPYVTLNSAAYTANSSALLYDPPIEEFSVVRLELKGEGARATFEGIEGPSVVICTAGSGTIKVGPKEEEIKEGYVFFVGATAEVVVEGKGKEGLVLFKAFCELEEGDDKGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0T3</accession>
    <name>F9X0T3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_67446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0T3"/>
    <dbReference type="STRING" id="336722.F9X0T3"/>
    <dbReference type="GeneID" id="13398238"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67446"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002149_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0T3"/>
    <dbReference type="OMA" id="SWLYHLI"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR036420">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="105"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="243"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="346"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="649"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="785" mass="87736" checksum="0132E249CD03A5DC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Z9</accession>
    <name>F9X0Z9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_66216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856322.1">
        <property type="nucleotide sequence ID" value="XM_003856274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Z9"/>
    <dbReference type="STRING" id="336722.F9X0Z9"/>
    <dbReference type="GeneID" id="13394803"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66216"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1031"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="F9X0Z9"/>
    <dbReference type="OMA" id="WLGFFKV"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="374" mass="41345" checksum="B6CAD6626A922CF9" modified="2011-10-19" version="1">MADVAAAAPNATHNEAREAALAYLNTRLASGASSKINRPFTVPEINIAPSFSDHVDDRKAVAALIGAACTTSGFFHITGHGVSDSARQGILKCARRFAKDLPREKKETLHVRHSHYFRGWEPADYTYVNPGDWGSELAAPETKDGFNWGYEAGLDPTGGDGKYRELDGADVNGNVWPSEDDLPGFYEDVKAYYSEVLQLARHLFRLFALSLGLPEDYFDAMTTHPGGIARLLYYPPSHDPRPLSSKQKDKEIGLGAHSDYECFTILLTSTASGLEILSPDNEWVAAPAAKDSFIINVGDFLMRWTNGVFQSTVHRVVNRTREERYSVPFFFSVNYDELVETLPSCVSAENPSKYPPIRAGEYVLERLRATAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1D9</accession>
    <name>F9X1D9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_24229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856594.1">
        <property type="nucleotide sequence ID" value="XM_003856546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1D9"/>
    <dbReference type="STRING" id="336722.F9X1D9"/>
    <dbReference type="GeneID" id="13398882"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24229"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024640_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1D9"/>
    <dbReference type="OMA" id="RDASTQW"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38978" checksum="201D6B6B6287EF7B" modified="2011-10-19" version="1" fragment="single">NTSALMLGVATTLKRIEASIPAFSRWLSNTSSPLICLVVDQTNLTDKANETARILSLAADLNIDLVLEPYHPTFEFDSEGLKNFGLAPVLDKHRRPNTKWYGLIDDDTFFVSLPRMLEALEPYDPTKQHYIGALTEGHFRVAKEGFKAWGGAGFFISPPLMKLLAERTTECTHLDKFFGDILWRDCILHVTSPTVHLTELRGLNQMDLWMDMSGWYEAGFTPILTVHHWKSWHQYPIVRGHTVADVAGPDSFLQRYLFTNNTVFTNAYSIVKYPKGLPDLNLVEATMTEEVNHKDPPDVLEFHHSFGRTRPKLKKGKEKISWTFQYAVMDDGRVRQFYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1K0</accession>
    <name>F9X1K0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856896.1">
        <property type="nucleotide sequence ID" value="XM_003856848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1K0"/>
    <dbReference type="STRING" id="336722.F9X1K0"/>
    <dbReference type="GeneID" id="13398262"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102956"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1994"/>
    <dbReference type="eggNOG" id="ENOG502S36H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1K0"/>
    <dbReference type="OMA" id="FTYHIHV"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391216" evidence="1">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="258" mass="25598" checksum="4D2C03DC6289B37C" modified="2011-10-19" version="1">MQFFTTTAAILAVALPLTSAGNAPTTTGNDQASGYLATLPQNALGVTGTVKIGAGQGGNGILVQVAIANLPDYGGPFLYHVHMNPVTNGNCSSTGGHLDTYGNGGTGCDLSNPASCEVGDLSGKHGKINGTTFSANYIDDYLSLDNGGAAVKGRSIVVHFGNKTAITCANLVSTGKTTITTDGSPLPSGYTMTSISNATAISATLFPETTDAPAETSTTKNAASETTEVVATQTVDGKGGVVGAGVAAGVVGLAAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2D7</accession>
    <name>F9X2D7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003855439.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13399802"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90864"/>
    <dbReference type="eggNOG" id="ENOG502SPA4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_539914_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2D7"/>
    <dbReference type="OrthoDB" id="3800957at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="505" mass="55404" checksum="496B25E499689364" modified="2011-10-19" version="1">MWVSRALMSCSKYEDFVLSRRSRLRIKAMVETFLKQGLVTQDRSRIRRWAGVFVLRQLVTAMFKNACNSGAPDWSVVIYRCLSITLSSALGCRPGDITTAWLQDHDLNYLAYMDITATMKKGGKPIDDLSATVVIRNEKGHKFNSHKNRTVPLNALPAEDCTICPIKLLLIHALRTGQVEETSIDELITNLARRPSRQVIWKNPKHPVLCAIGARSIGLDLEEPAIHTQMDGTLEQASVAAGLLAVLKSYDLRRGAARDLANNPDVITGTANAGVGAGLGHLTTSVNVTAHYIGDYNFDHYSARVANPYQDQTESIPVAIEPFQEAQHTKAEVTAACEPAVQMNRNQAFSGLRKRKREDWRAEQTNKRHLPSGSVSNIDTASSDSATSASSVASATPAPLATTDETEFILDPALREPADTADRMLFRQELSEERAFDLEDLALDYAVGQDSSSSASLPAWMTPDDNLEFVRRASTINVSSHTAHGAVLQHVFHLLIGGSRDAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X362</accession>
    <name>F9X362_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_108281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855339.1">
        <property type="nucleotide sequence ID" value="XM_003855291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X362"/>
    <dbReference type="FunCoup" id="F9X362">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X362"/>
    <dbReference type="GeneID" id="13400080"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108281"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1011"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="InParanoid" id="F9X362"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395301" evidence="9">
        <location>
            <begin position="22"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="189"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="556" mass="62063" checksum="D5D16E75A3452030" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3B3</accession>
    <name>F9X3B3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_27344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855827.1">
        <property type="nucleotide sequence ID" value="XM_003855779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3B3"/>
    <dbReference type="GeneID" id="13395905"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27344"/>
    <dbReference type="eggNOG" id="ENOG502SIQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_3_2_1"/>
    <dbReference type="InParanoid" id="F9X3B3"/>
    <dbReference type="OMA" id="ASERILW"/>
    <dbReference type="OrthoDB" id="3626637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="274" mass="30975" checksum="20834583BBC1EB31" modified="2011-10-19" version="1" fragment="single">EPLEAEKHELRLLTLLPGAFHEPIRCTLAKICLKDTERPLYEALSYVWGDPKITKYVMVHGALFHVTINLESALRHLRDKNDPRTLWIDAICINQNVTDGREDKERHGQVRMMGQVYTSATRVIIWLGTGDQRVVNVIKTLQTAGKGSIDSASMLIAAPLYRITSLDWFNRVWTKQEMVLAVNDPIIIYGRCVIPWSLLTAVCQQFKAEVLRTHVGIKGVIAMKQLGMWRITGLDDLRTLYQSDRGLLLSQAILCSGYAKATNPRDMVYGVLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3E3</accession>
    <name>F9X3E3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_67821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854759.1">
        <property type="nucleotide sequence ID" value="XM_003854711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3E3"/>
    <dbReference type="FunCoup" id="F9X3E3">
        <property type="interactions" value="975"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3E3"/>
    <dbReference type="GeneID" id="13395944"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67821"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.159"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="InParanoid" id="F9X3E3"/>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33309" checksum="B7807F39BC1AF5DE" modified="2011-10-19" version="1">MSNYGYQSPSNQQQPYSAQSNLNFYQSSYSAQPVSGQSTPFQAFGAGAGGQAYGQPGSYGAGGANYGFGSFPGQPGASGQMGTGQGGLRTGWFAAFGTEGYDGEPPLLEELGVNFNHIQMKTLTVLNPLGRIDQHIMDDADLAGPFLFCALFGTFLLLTGKLWFGYVCGLAALGAISLNFVFSMMSPPLSQDEMNAVQSSQNNYHGSSNLSSTLTLGRSSSVLGYCLLPLVFASLFGVIIPLDTFVGYCLVSLAIAWCTYSSSAMFCVVGRMTNMRVLVAYPLALFYFGFGIMAVFSSRGTGRIDEMTVKAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q2</accession>
    <name>F9X3Q2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_79452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854962.1">
        <property type="nucleotide sequence ID" value="XM_003854914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Q2"/>
    <dbReference type="GeneID" id="13403466"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79452"/>
    <dbReference type="HOGENOM" id="CLU_2514379_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3Q2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="85" mass="9810" checksum="4B42D0E0D40C0DE5" modified="2011-10-19" version="1">MEIRTVYTKLRQRSQQNWRLQEAERSWKANGEAGKLVKVEDNPGEQHGTLWRLYGECDVEPGPSIWSSIIRYVAPATSRRRVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X455</accession>
    <name>F9X455_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_35590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854789.1">
        <property type="nucleotide sequence ID" value="XM_003854741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X455"/>
    <dbReference type="STRING" id="336722.F9X455"/>
    <dbReference type="GeneID" id="13395974"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35590"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013989_4_0_1"/>
    <dbReference type="InParanoid" id="F9X455"/>
    <dbReference type="OMA" id="PWWFASV"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Lon_prtase_N"/>
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        <property type="entry name" value="Lon_prtase_N_sf"/>
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        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="517" mass="58400" checksum="D703E5C665315DB0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4W5</accession>
    <name>F9X4W5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_37542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855206.1">
        <property type="nucleotide sequence ID" value="XM_003855158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4W5"/>
    <dbReference type="GeneID" id="13400494"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37542"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="F9X4W5"/>
    <dbReference type="OMA" id="ENERRYH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39968" checksum="E38364BCE1B6676B" modified="2011-10-19" version="1" fragment="single">AYDWTYENGRRYASTELGHYYMPNDEPEIQRLNEQHWILTQVKGGKLHHAPLPKRDGLKILDVGCGSGIWCLQIAEDYPKAMVFGMDVSPVQPQKKPANVEWFTNDMEKEWPFPDEYFDFIHLSLVHGCVGDWDEMLAKMVRHLAPGGFLEHQEFSLCRQYLMDEDDKPLPMSDDISELPPFFQWNRYMDQAAQKRGRPLQLGPHLHTFQEHAGLLDVHEIVFPHKWGTWPNDPTERALGARTMLSAMSGMEGFTTILFTKVLGWSLEDTQAFILKVKRDMRDDSLRKVMDLHVVYGRKAGYPNDASRNASHSTGKSQYVQVGMGILLGAAIASVASLWFMRRRKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4Z3</accession>
    <name>F9X4Z3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_99350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855233.1">
        <property type="nucleotide sequence ID" value="XM_003855185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4Z3"/>
    <dbReference type="FunCoup" id="F9X4Z3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="13400478"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99350"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1230"/>
    <dbReference type="eggNOG" id="ENOG502SC39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_0_1_1"/>
    <dbReference type="InParanoid" id="F9X4Z3"/>
    <dbReference type="OMA" id="SAIVWFE"/>
    <dbReference type="OrthoDB" id="3888684at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391344" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10132" checksum="41E7279B65D6A383" modified="2011-10-19" version="1">MKFSLAPLLVLGLAAGAMAKDQTQQVIISYPNNTPASVLEGAKKAILDAGGVITHEYSLIMGFAAKVPAKVLESVQAMGQEHNVLIEQDQIVSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5C7</accession>
    <name>F9X5C7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_56118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853617.1">
        <property type="nucleotide sequence ID" value="XM_003853569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5C7"/>
    <dbReference type="STRING" id="336722.F9X5C7"/>
    <dbReference type="GeneID" id="13395860"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56118"/>
    <dbReference type="eggNOG" id="ENOG502RKCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_0_1"/>
    <dbReference type="InParanoid" id="F9X5C7"/>
    <dbReference type="OMA" id="CADWEGM"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="213" mass="24656" checksum="A391C11B7C9E2071" modified="2011-10-19" version="1">MSNTDSPSLWRQEPSPEVDKLWEDHWDSNPMLMPVEDVVKIGHDPDYVVRWASGARHPHRTIVSNHAHHLLHCLDELRKSVWTSHYWPDGNMNPFHRNHQAHCIDLLRQDLMCRAPRNVVSWIWMESEPAPQPNFNVSMKCANDGWDDMWSWWKERQLTKEQLGTEEPAKPAGVKEWPASSAQKKENEALKELCSQPGVKCTQAGEPVDFSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5F1</accession>
    <name>F9X5F1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854659.1">
        <property type="nucleotide sequence ID" value="XM_003854611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5F1"/>
    <dbReference type="STRING" id="336722.F9X5F1"/>
    <dbReference type="GeneID" id="13395845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37741"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.38"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031573_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5F1"/>
    <dbReference type="OMA" id="ELDKRAW"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42485" checksum="F95407DF8B1051BB" modified="2011-10-19" version="1">MSAVDLQSLLRFLTKDAKLPLALAMSKVKDLQAANLDSPESIAKVKPDALRPIFEDEKISKQIISAAKRLTKKRSAGELDDNPPTPKKKCKAESLFTDQTPLSPTAMEFSLTLPTSSLPFSSLSSTCLITNRAPLVLAFLVTLLKYTMPEQPLSSRLSLAQAYVSQTSKKRAIYLGIEDGKTAEEEGFGEGLPQVVVGGKEVKVLRRWGYEWRGEGEVGEVEVEGKVEEGGGVKVEEGDGGEDGQEVQAEEKPALWALDLEALKKTDDSSKRSDYRIGTYSNLPIHTPQSARAYIMKAFASAPSTEAATTKKPTAKAAAAEKEANLGKLLRALDLLYESWATTLSAEELDARTWGWYVKVRPSVEDGVAGWGGKNVLKLGDILALRRAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5F5</accession>
    <name>F9X5F5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_117763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853629.1">
        <property type="nucleotide sequence ID" value="XM_003853581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5F5"/>
    <dbReference type="GeneID" id="13395843"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117763"/>
    <dbReference type="InParanoid" id="F9X5F5"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="452" mass="48364" checksum="9C334741F27AC1B5" modified="2011-10-19" version="1">MQSKGRRPCNGELPTRPSQKPNVYTADLVWTNQGASPGLTVTLGGTNLTVFVDLGSSVFWVPGADWKCVDDINTKLKHVPQENCAPVEGGTTSPDFTFSGGQIPGARFNSTYNAGKTGALGIIGYEDITIDGGLAITNVTTGVATGWDNPLSGTAYGMMGMGFPPATSYWPESELEAVGGQIKDLTHITHYNPVAIQAAAEGVIAPMFGYYYDGLGEPDGTHCGQMTFGGEPDIPHGEFTADIPIVPGVQLSDPSHPVFDIWNIHVDGFKIIPPTPGAEPIVISYLNEPNPDAPAAIPGSAYWNHTHTLDTGAYFSAIPDEVYFELIKHFDPPLSKEGSTACDAKIPQLAVTVGGKDVWFNESGILYPEIFAPDEAPACDLAIIQTEGLGATLGTPFLINVVAVHEFAEGTVPTVKFAQRIWERIFISSVGMTNIENVPQAFRVLFPERPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5J1</accession>
    <name>F9X5J1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_108499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="SEAHWAQ"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="454"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="641"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="305"/>
        </location>
    </feature>
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        <location>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129102" checksum="0F6F639EEC0EDA8C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5T7</accession>
    <name>F9X5T7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854024.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5T7"/>
    <dbReference type="GeneID" id="13395440"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103897"/>
    <dbReference type="HOGENOM" id="CLU_1972209_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5T7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="127" mass="13712" checksum="2F3CFDF25D330B40" modified="2011-10-19" version="1">MDANQKEADKWQAAEEEADALALGMSVEEARQKTASKAALRPSGGADVSEWHMPGGHDALPQRAKKVKTATLSRKSHTLPRKSATLSDKPKPEAETYHRPPSVAPHFAVEIFGEAAADVVKTESLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5W9</accession>
    <name>F9X5W9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_85399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854238.1">
        <property type="nucleotide sequence ID" value="XM_003854190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5W9"/>
    <dbReference type="GeneID" id="13404578"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85399"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.933"/>
    <dbReference type="eggNOG" id="ENOG502T9JU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3068652_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5W9"/>
    <dbReference type="OrthoDB" id="3649718at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395360" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="57" mass="6230" checksum="BA3A05F1FA188018" modified="2011-10-19" version="1">MMGWLVVQGLGVVLLADLAFATLTNDRTTIRSVAQSAGYWKDPPPFDEVHGLKKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6K0</accession>
    <name>F9X6K0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_37885</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 15"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853663.1">
        <property type="nucleotide sequence ID" value="XM_003853615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6K0"/>
    <dbReference type="FunCoup" id="F9X6K0">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6K0"/>
    <dbReference type="GeneID" id="13395807"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37885"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="InParanoid" id="F9X6K0"/>
    <dbReference type="OMA" id="AQIWACS"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052724">
        <property type="term" value="F:inositol hexakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000830">
        <property type="term" value="F:inositol hexakisphosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000831">
        <property type="term" value="F:inositol hexakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051516">
        <property type="term" value="P:regulation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110162">
        <property type="term" value="P:regulation of mitotic spindle elongation (spindle phase three)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="208"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="474"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="656"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1223"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="822"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139972" checksum="DB9EE8E18BCC77EB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6T7</accession>
    <name>F9X6T7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_99503</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854480.1">
        <property type="nucleotide sequence ID" value="XM_003854432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6T7"/>
    <dbReference type="STRING" id="336722.F9X6T7"/>
    <dbReference type="GeneID" id="13404111"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99503"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_1_0_1"/>
    <dbReference type="InParanoid" id="F9X6T7"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
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        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390169" description="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial" evidence="16">
        <location>
            <begin position="31"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="395"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="512" mass="56281" checksum="EB098CC9FD1DA033" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R5</accession>
    <name>F9X7R5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_99524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854460.1">
        <property type="nucleotide sequence ID" value="XM_003854412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R5"/>
    <dbReference type="FunCoup" id="F9X7R5">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7R5"/>
    <dbReference type="GeneID" id="13404142"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99524"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.452"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021611_3_0_1"/>
    <dbReference type="InParanoid" id="F9X7R5"/>
    <dbReference type="OMA" id="GSPWTTK"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50012" checksum="DE398BB7414AC174" modified="2011-10-19" version="1">MDRLKKLFAGEDEQRYSALHTNDIEGDEEHPSSQLNDKPLPVRHVEYSIFLLLGISMLWAWNMFLAAGPYFQHRFRSNKSIYANFQAAEITVSTVTNLGSMLILTKLQRAANYPNRIVLSLLINMAVFALLAASTAVEVSAEVYFVFLMGMIFAASLATGLCQNGVFAYVSGFGEPKFTQAIMTGQAVAGVLPCIAQIVSVLAVQHSKSGQSERHGDKGELPTGPTPVNWKAALAYFLTATLISIATLLAFTYLLARTRPSISSSSTTPNTPTASTADLRATTTSLKKPIPLTLLLRKLLPLSSAVFLTFAVTMVFPVLTQRILSTHPPHSQPPILQPPSFIPLALLLWNIGDLTGRLLTGLPAISLVHRPWIVLAMAIARVGWVGLYHLCNLDGKGAVVESDVFYLVVVQLGFGLSNGFIGSTCMIGAAEHVDEEEREAAGGFMGLCLVGGLAVGSGLSFFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X870</accession>
    <name>F9X870_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHS5.1</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_70672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852833.1">
        <property type="nucleotide sequence ID" value="XM_003852785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X870"/>
    <dbReference type="FunCoup" id="F9X870">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X870"/>
    <dbReference type="GeneID" id="13397155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70672"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.91"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_0_1_1"/>
    <dbReference type="InParanoid" id="F9X870"/>
    <dbReference type="OMA" id="ACEQNGR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="42229" checksum="A4BE2B3716DE84A0" modified="2011-10-19" version="1">MLVSLTVGKVDAGVAVLLTEDKRLIEFPSILLPPDIHSGSIVDINVSRNQHAELIADQKFSALQNEIFQTFGQASPSAPVLRCRNTTQTSIVLEWDPIELATADLRSLSLYRNGTKAGVIPRDKLSTKISGLALDTEYTFHLVLRTSAGQYTSEKLTVRTHKMTDLSGITITPGVMPGQLRDSLAETVNRMGAKMIDTVRIDTTHFVCTEPRGQAWEKAVEMNVPVVVPDWVKGCEREGKIVGVRGYYLDADPKHRQMGPSSQEHRGSVSSVAPQQSGPRIEHTPPTPERTTTQRFAARQDSSEAPTPPPKPVQERISEEETPQAAHAPVATQEEKTVSPLESDEEESDDEGQDPEKAAAAQKDAAVSPVSPSDGPADEEGKFDEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8F5</accession>
    <name>F9X8F5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853011.1">
        <property type="nucleotide sequence ID" value="XM_003852963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8F5"/>
    <dbReference type="STRING" id="336722.F9X8F5"/>
    <dbReference type="GeneID" id="13397332"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109136"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.468"/>
    <dbReference type="eggNOG" id="ENOG502SWDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012433_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8F5"/>
    <dbReference type="OMA" id="AMTVMSS"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="349"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="77945" checksum="54C6E887B02B6597" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8P6</accession>
    <name>F9X8P6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_40209</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853102.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13399746"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40209"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.801"/>
    <dbReference type="eggNOG" id="KOG0254">
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    </dbReference>
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    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="198"/>
            <end position="220"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="295"/>
            <end position="314"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="417"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="75"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="609" mass="65131" checksum="EFC5D0721EFD20EE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8U6</accession>
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        <recommendedName>
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        <name evidence="5" type="ORF">MYCGRDRAFT_70772</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:anaphase-promoting complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin ligase activator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </feature>
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        </location>
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        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87843.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62605" checksum="7AFE2DD201949671" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8W2</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13397254"/>
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    <dbReference type="eggNOG" id="KOG0598">
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    <dbReference type="Proteomes" id="UP000008062">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="573" mass="64242" checksum="9AB62FEFEB521EA4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8Z6</accession>
    <name>F9X8Z6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_41050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852947.1">
        <property type="nucleotide sequence ID" value="XM_003852899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8Z6"/>
    <dbReference type="GeneID" id="13397268"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41050"/>
    <dbReference type="eggNOG" id="ENOG502SU86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150214_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8Z6"/>
    <dbReference type="OMA" id="MSDMKRT"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15955" checksum="A74EC05523F64657" modified="2011-10-19" version="1">MGHPAFDSKPHSQGYVSAGSDTRKSSSSGGKKRASRAGTRSVTTLSAAQLERKRANDREAQRAIRQRTKDHIDHLERSMNDLRGTQEAHEKIAHIAQQRNRELEDENAYLRSKLQEAGVPVNLPPPSEGESVAEMNSRTNVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9I2</accession>
    <name>F9X9I2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_41304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852956.1">
        <property type="nucleotide sequence ID" value="XM_003852908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9I2"/>
    <dbReference type="FunCoup" id="F9X9I2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9I2"/>
    <dbReference type="GeneID" id="13400421"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41304"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.351"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042181_2_1_1"/>
    <dbReference type="InParanoid" id="F9X9I2"/>
    <dbReference type="OMA" id="HIYLIWA"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="154"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="397" mass="44850" checksum="DFFDA355C1F5FEC6" modified="2011-10-19" version="1">MGALRNIVIAVLAISFLTFVALFGRLPALRKTPIGWLQRLLCLHIPSGLRSADRSLTGGRVTRKSKRLGQYLFYEKNPIVLIIFLFILTGSAFLFLYNTTHLLTRSQLLPVPVLVGMPYIFTYLSVTGRAHYISKANLNARMLDYPYDNALFRPNNHCPTCDIVKPARSKHCSLCGTCVAKCDHHCPWVNNCLGRGNYRYFLALLLSLGMVQIYGAHLSWQLVKKYVVIDPSNPLFSRARMTNLGHAFVIAVNRGGISVSGVGLLAASTASLPLGLLAYHLYLIWAGMTTNESQKWSDWKEDISDGCVFKTRLADLRRHYQLKNDGKYNPAMTDFESASDRNIWWPVNSDQVLVRTDDGRPPIGQDMLWTRIWSLDEVDNIYDLGGWQNFVEVFRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9I3</accession>
    <name>F9X9I3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853451.1">
        <property type="nucleotide sequence ID" value="XM_003853403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9I3"/>
    <dbReference type="FunCoup" id="F9X9I3">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9I3"/>
    <dbReference type="GeneID" id="13397278"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109076"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.352"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9I3"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="33"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="425" mass="46665" checksum="93E1AEE601FCC09D" modified="2011-10-19" version="1">MSKRKRDDEPESGAVKIYKDYRKLRQIVGAFNESSEQLAKAFKTARGFERQKLGRRRKNAAAQKDDKDVERIDAEVAALKTLDVTTAAQHHLAKSLLKIKAVATCLELPVEISKPKPLPSDAPSLNVNARLCNSNPVKEVFAPAMTRVKAVFGIVDEVAAPAKKKRLRAKDYENVAAGEKAEVKAAAVDTQEEDDIEAMAESDEHSDVEMDDYRGRLASSDDESNMAETSDVEELERMLAEEGLSRKPTSTNKYDPAADLSLDDASSRTDSEGEIEKAKPKKAATTAIKKSAFIPSLSMGGYISGSGSDLDDDLDIAPKKNRRGQRARQAIWEKKFGTKAKHVKTQDRNQGWDAKRGAVGGRDEKPHRFANAANAQPLGPRKGEAKKPKERDDTGPLHPSWEAAKKAKEKKAVPVVFSGKKISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9N3</accession>
    <name>F9X9N3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853348.1">
        <property type="nucleotide sequence ID" value="XM_003853300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9N3"/>
    <dbReference type="FunCoup" id="F9X9N3">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9N3"/>
    <dbReference type="GeneID" id="13400167"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40355"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_0_1_1"/>
    <dbReference type="InParanoid" id="F9X9N3"/>
    <dbReference type="OMA" id="ECSKTDT"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="179"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="426" mass="47510" checksum="11028D3C60D97351" modified="2011-10-19" version="1" fragment="single">MVPTPRSYTSGSSRNKATLEIIPDDRFIVFNGGEHEAATFKLTGRVRLTTPEAMSIMRPKVRLEGKRKISWWYMGGISTGEVMDKRVFWNQEQRLGIESAHKIKAGTIEWPFEFDLSPTMPESVEGLRETFIAYHLHASVSRPGWNAKDITAQEHIRIVRTLGQDSMEMTRSRVNADIWANKISYSISIPTDAIVFGTSVTADVELSPIKKGITLGKVEMKLIETVVKRIQANEVPDVRGDRSKSEETEVAKAEMDFPEHSRITYDDDTTDNPTLADEMYKFQATLPLPKSLNACRQDVDSHSINITHRFKLMVNIHNPEGHVSQLVCRLPVKLFISPNLPVDESNMVCGNANGVSDAQLNLTETALVAPPEYGRHQLDQMYRDIDPSGFMSRAGSGPGTPAGLMSQSRRGSHENILSLNGLAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Q7</accession>
    <name>F9X9Q7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_104241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853074.1">
        <property type="nucleotide sequence ID" value="XM_003853026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Q7"/>
    <dbReference type="GeneID" id="13399287"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104241"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.602"/>
    <dbReference type="HOGENOM" id="CLU_2212051_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9Q7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="107" mass="11997" checksum="B3AFA7470C5B463D" modified="2011-10-19" version="1">MYLLPSDKNDPADDAAAGDSTQFGVDVFQLPTDIVRQQRSATSRFEELRQSMANLKTASERLTEETAWLDGRVRAVVTCTNILGAGIDHLMKEVDWIVDERSVRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA12</accession>
    <name>F9XA12_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_71416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853314.1">
        <property type="nucleotide sequence ID" value="XM_003853266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA12"/>
    <dbReference type="FunCoup" id="F9XA12">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="13399982"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71416"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.643"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA12"/>
    <dbReference type="OMA" id="FVDAYPK"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="99"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="384" mass="42888" checksum="CA4AEBFA5B854997" modified="2011-10-19" version="1">MAPGLVENTLNDVSDVAEKEYIKDKLQSTESKEAFGQSAKTTNYDVELRGDGKHAPAAYPHYLPYWDPDTRYPPYEPFEAVQPGKNADPSFPNLLAGAEVRDLTANIGAEVTGVQLSKLTNAGKDELARFVAEKKVVAFRAQDFADLPIQEALDIAEYFGPSHIHPASGAPKGFPKVHLVHRSASDTTAKDYFQERTNSITWHSDVTYEMQPPSTTFLYRLDGPDAGGDTLFANMAEAYKRLSPAFQERLHGLKAVHSGHEQAQQALARGGIVRRDPVSNVHPIVRTHPVTGEKALFVNTQFTKRIVGFKKEESDFLLKFLFDHVALGADFHARVKWEKGTVVVWDNRVTAHTALLDWQDGQRRHLARLTPRAERPFETPFESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA86</accession>
    <name>F9XA86_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_85715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852997.1">
        <property type="nucleotide sequence ID" value="XM_003852949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA86"/>
    <dbReference type="FunCoup" id="F9XA86">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA86"/>
    <dbReference type="GeneID" id="13400231"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85715"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.436"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="F9XA86"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="38513" checksum="95D716BACFD2DB3E" modified="2011-10-19" version="1">MAASKTLRIGLIAGDGIGREVIPAGRRLLEALPASLGLKFSFVDLDAGFETFKQTGVALPDKTVETLKKECDGALFGAVSSPTTPTKGYSSPIVALRKKLDLYANVRPVKSVAPSAAFPDPIDLVIVRENTEDLYVKEEKTYDTPQGKVAEAIKRISERASSRIATMAGEIALRRQKIRQSTGVDGKSMVTITHKSNVLSQTDGLFRQVARRALEEKRFVDGGVVIDEQIVDSMVYKLFREPSTYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGDGFAIGEPCHGSAPDIQGKGIANPIATLRSVALMLEFLEQEEAAAVIYKAVDANLLEGKLLSPDMGGSAKTEEVLQDIIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAC1</accession>
    <name>F9XAC1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92792</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853114.1">
        <property type="nucleotide sequence ID" value="XM_003853066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAC1"/>
    <dbReference type="GeneID" id="13399327"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92792"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.707"/>
    <dbReference type="eggNOG" id="ENOG502RVTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685125_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAC1"/>
    <dbReference type="OMA" id="NNEITWQ"/>
    <dbReference type="OrthoDB" id="3650655at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395568" evidence="2">
        <location>
            <begin position="26"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="420" mass="45784" checksum="DF8ACC60328570C3" modified="2011-10-19" version="1">MKLNIGSNALLFASLVSCIPRSTLGFPLTQAIDSLGPQSGHDIFNPRLGGTYGNDILWQDADISSLETRKRAAAVGARGFPKGFIPEAPRLPVPPPRAFPGGTAGLTSGPAFSSERPKALGPGDPPPRTVTPPREDPPAPKSDWKAIPEDLDPGTGKKGLDEVRSVEEYETDGHAAIAEYAEIAAGPGPDTLIGTAIPGHTAFPNFRSLEHYRVDEDDWEFDYKLQNGAYRDLLKIFNSNELGFNLKDNKANVKMISIANKKGGAPINRGIYDTEGRFIMYQEADKRAQPKDGYQLPVWEMGMQSFIESAPGKTQNLKVVFLMDIQNTEFYKIVRANYNEAKQPFDQILTFNSGTPAFNRIMGSPNFRSKFLAYGYHHNAIGNKVPDKVVVAPKQAQKLAEGVSGTQLYAAVIFKEAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAL7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92970</name>
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    <organism evidence="3 4">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852043.1">
        <property type="nucleotide sequence ID" value="XM_003851995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAL7"/>
    <dbReference type="GeneID" id="13393818"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92970"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.54"/>
    <dbReference type="HOGENOM" id="CLU_647602_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAL7"/>
    <dbReference type="OrthoDB" id="10637899at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="47736" checksum="726FA32673316679" modified="2011-10-19" version="1">MALDTLIGPHANITGHYTTAAMQKTLLGCTEHVFKLLEDHVEHYVCNGKSFQETWSSIEQSKYSWCKALTRRMTGILPATLESVKTNMYISALSRNQADGQAEALSKAKVVGETTDTKRRWNQDRDQDDDEPEPVKKVKIEAEQPTEAQQQSLLALHARKTTAGQPAAAEATYPSEVSTNDASAQPGNGLDLDSSEIASKATPLLKEMLGPGEKQTVMQAMESFLETEMKTRVEKANSEIGHKARLDAREKDLERRESSVAKMSALVASKVAEQDQSEKMLEEREKNVLADEEQLNELKNVLEVRDKELAALDKKLTAKAKKQDEEGKWLRDEGQQQGRMRAQLQDEMVEADQAKKRKQKSAKKEKAKWTSEMTERIRAELVKGMNRALDADQAKWTSEMTERIRTELLKGMDRALNADRFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAU8</accession>
    <name>F9XAU8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_42063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852086.1">
        <property type="nucleotide sequence ID" value="XM_003852038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAU8"/>
    <dbReference type="STRING" id="336722.F9XAU8"/>
    <dbReference type="GeneID" id="13393862"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42063"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019412_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAU8"/>
    <dbReference type="OMA" id="HVHVLDF"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="505" mass="57140" checksum="4E0770FA1ED056AB" modified="2011-10-19" version="1">MPNATRRCSVRDVAEIEQEAAELCEWANLLVLAPIDANNLAKMLHGQTDNLLLELLRGWDVSKKILLLPGMSSAMWENPMTKKQLTKIRRKWNWVQVLQPMLWNFVKDEKKLVSWEATSELVDAIRNQVDLMNIGSGLELSPSKRYAFSHTGNGATSRLPDELWTMIFDYTNDWELAQTLHIFTNIPPPSEWASHVTPQGPSNYMEALELTILRGQLSDVKHFIATHSVPRWLSKLCIRLIMRFAMTPLLAHLEAAHKDLFWATFGHTFLPDKASSIFGATEILEFWRTSPSFLTKEYNVEALDGASRAGFVHVLEWWQHSGLPLKFTEAALEQASSQGHIAVLEWWRSQSTSHDDSKSTVADSSKVRLKPGKSICYATQNGHTDVVRWWLSSGIAFPHEETVAKLASTHGHVDILSAWHEAKGSKMIFDNQVLVGATKSGNVSVLEWWRRSGLKVEYKTCDVEEALEDGDEGLRGMEVRKWWARNGLNLGVGTSEWMKTKVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAW4</accession>
    <name>F9XAW4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_58719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852722.1">
        <property type="nucleotide sequence ID" value="XM_003852674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAW4"/>
    <dbReference type="FunCoup" id="F9XAW4">
        <property type="interactions" value="901"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAW4"/>
    <dbReference type="GeneID" id="13393867"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58719"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="F9XAW4"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="152" mass="17273" checksum="D99ABF9459C4CF8A" modified="2011-10-19" version="1">MSAPLPKRIIKETERLQNEPVPGISATPHDDNARYFDVIVEGPGGSCYEGGVFHLELFLPDDYPMCPPRIRFLTRIYHPNIDRLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPEDPLNEAVAKQWKENQPEAIKTAKEWTELYAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAX1</accession>
    <name>F9XAX1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_72272</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852577.1">
        <property type="nucleotide sequence ID" value="XM_003852529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAX1"/>
    <dbReference type="SMR" id="F9XAX1"/>
    <dbReference type="STRING" id="336722.F9XAX1"/>
    <dbReference type="GeneID" id="13396900"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72272"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.480"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="InParanoid" id="F9XAX1"/>
    <dbReference type="OMA" id="DMCSEYS"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="218"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="46740" checksum="07951CCE0CB50EE3" modified="2011-10-19" version="1">MAPGALLVTSQNGRTSPLYDSDGYVPAPAALVVGGEVNYRGYHHAEWWVGNAKQVAQFYITRMGFEPVAHKGLETGSRFFASHVVQNNGVRFVFTSPVRSSARQTLKAAPLADQARLDEMYDHLDKHGDGVKDVAFEVDDVLAVYENAVANGAESVSSPHTDSCDEGDVISAAIKTYGDTTHTFIQRTTYTGPFLPGYRSCTTVDSANKFLPPVNLEAIDHCVGNQDWDEMSDACDFYERCLGFHRFWSVDDKDICTEFSALKSIVMSSPNQVVKMPINEPAHGKKKSQIEEYVDFYNGPGVQHIALRTPNIIEAVSNLRSRGVEFISVPDTYYENMRLRLKAAGMKLEESFDIIQKLNILIDFDEGGYLLQLFTKPLMDRPTVFIEIIQRNNFDGFGAGNFKSLFEAIEREQDLRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB20</accession>
    <name>F9XB20_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852259.1">
        <property type="nucleotide sequence ID" value="XM_003852211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB20"/>
    <dbReference type="STRING" id="336722.F9XB20"/>
    <dbReference type="GeneID" id="13396873"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109581"/>
    <dbReference type="eggNOG" id="ENOG502R6WM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029214_2_0_1"/>
    <dbReference type="InParanoid" id="F9XB20"/>
    <dbReference type="OMA" id="SDNLYDC"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="469" mass="51858" checksum="D9DBF88E7BE46C01" modified="2011-10-19" version="1">MAPRAAALAASTTYDSDDALQSSNGLDDKRNMTATTRAKTTTRRASAGKPATKRKAAPKQPRQALKDRTNLQPASDTEEVEEFDDDAMDTKPKAKRAKTTAARKPAASKETKKSTVLAKKKTVKRAPSLDALATIPETQQDPDRMEDVEQSIEVDPSNMDIAQEPTPKPIQKFVQRAPSLQPRASTRPGSSQPTYAPIRERSGSASAVERRGGDPELRRSLNEMTKKYETLKLKHESLEEIGKSSAETNFEKLKRASDQKAKDASELIASLKKELADLKKSTSSVSTETTGLQKQIDSLTTSNNKLTVERDDLKGKHQVSQNEVKSLEAKLMTARQQISHSAQEAETAAKKHTTSTALSLGDAQKEAKMKENLYADLTGLLIRAVKPLHFHLSIANDSTTPHPKTPSGLSYEEAEFAYEPLLDESRDRDLLDLLPDYLTEEICFPRNHAQRFYSKVVDSMTKRIIVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB62</accession>
    <name>F9XB62_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_104684</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104684"/>
    <dbReference type="eggNOG" id="ENOG502SY3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101047_2_0_1"/>
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    <dbReference type="OrthoDB" id="4502478at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="14161" checksum="9B872078E0BD8736" modified="2011-10-19" version="1">MSPTAPMLAQSESKVMFFSRLGLDERNKTHRHIYSQMKEEAAGGWKRMTATRESLASQYKNDLSIQAPYTFNQIDERVIQLEILAIHRRARSQTRLIYDLGRDFYDGHEENWIIRWLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM6</accession>
    <name>F9XBM6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93128"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.255"/>
    <dbReference type="eggNOG" id="ENOG502RK98">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001586_0_0_1"/>
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    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="260" mass="29238" checksum="1DADDA341692DB1E" modified="2011-10-19" version="1">MSPLIIDDHSPSVSPTRRARSSSFAVTMAKPRDCPRLVDIEFCAFANERTNHLLSYRDPHQKADSERAVRCYRSLLRRNNRRAGSSIVSFRKVTDTTTGKIISFAKTEFKAYTEEELASRPDTGHEGESRMNRDWFALNEKWRRAYVGTRRHCYLGMVATQPAYQQRGAATMILEPILGDADAEGVECYLEATSTAKPLYERHGFVAVGELSFDPAAYGVFGYKVETQTVMVRGALDSRGVRQEVTPWNVETGPVQAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC70</accession>
    <name>F9XC70_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_100203</name>
    </gene>
    <organism evidence="10 11">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGP87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC70"/>
    <dbReference type="FunCoup" id="F9XC70">
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100203"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.346"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="F9XC70"/>
    <dbReference type="OMA" id="LFKALWY"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
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            <end position="180"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="282"/>
            <end position="303"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    <sequence length="546" mass="59888" checksum="0547A89B1E8EF22B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="211"/>
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            <begin position="157"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="EGP87602.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="20606" checksum="0CA1DF9BEDDD1443" modified="2011-10-19" version="1">MYTSITFVALATLALARTDLTGCTSTDVSSPAGASLAYYVPGTGELCEFLDCGGGRAPPKTTVPGCPQYSGTLTYSPSFLPGYGSATAAPSVTSGASAESTTTASMSESSISSETMSDSAVSSASSSTSMSLSSSPGSTTSSSMSTITSVAVAPANGTITNPATSGRNNGTVATTRSPSASSVTDSGAMETARVWASGAGLMGLGALMMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCI6</accession>
    <name>F9XCI6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852161.1"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XCI6"/>
    <dbReference type="GeneID" id="13393985"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_59052"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.411"/>
    <dbReference type="eggNOG" id="KOG0205">
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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        <property type="entry name" value="HAD-like_sf"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="925"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111073" checksum="2EA562CA2026E070" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD47</accession>
    <name>F9XD47_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="8">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_109813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851444.1">
        <property type="nucleotide sequence ID" value="XM_003851396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD47"/>
    <dbReference type="FunCoup" id="F9XD47">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="13393654"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109813"/>
    <dbReference type="eggNOG" id="KOG4760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013225_1_2_1"/>
    <dbReference type="InParanoid" id="F9XD47"/>
    <dbReference type="OMA" id="FRDECEW"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="8">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="720" mass="80596" checksum="CE6E24FC9FDB5751" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDD2</accession>
    <name>F9XDD2_ZYMTI</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_73123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851497.1">
        <property type="nucleotide sequence ID" value="XM_003851449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDD2"/>
    <dbReference type="GeneID" id="13401556"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73123"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.345"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDD2"/>
    <dbReference type="OMA" id="GYGWGFM"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="494" mass="52938" checksum="0D97E4E55824A953" modified="2011-10-19" version="1">MSRQPSETSPLLANNNNRQPGFDDANAKNIVDFDPNGDEANPMDWSNAYKYGIVALLAFTAFTVTFTCIAVVPVASHIVKDLDGHPDKSSSVLLVTIWELGEAAGPLFLAPLSEIFGRYPVMNGANMLFIAATLLASFAPTSAVLIAARFLTGLAVASNVLNPSIVGDMFVSEERGTAMSFIMLAPLMGGAIGPAISGAVAETLGWREMLWICAGLAMACEICFLTLFRETFKVPILARRAARLRKETGNEFLQTRFEFEGSQKTGKVWESIMRPIVVFCGSGVLQAMSIFGSVSYTYFYVISVTLPDILEDQYHLSAAATGAAFVSFSAGSVVSVVLCNRGLDRIYIHMRSKNNGVGLPEHRLPLAIAGGFLLPVAILYYGWAADVHLPLAAMLVAVGILGASLMLSVLPLMAYVVDAFGLYSASAMTAVIVTRCLMGTFLPLAAQPLIDKLGMGPAFTCLAGLSLALAPVPVAVMRYGAKWRQRSKYTRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDE2</accession>
    <name>F9XDE2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDE2"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93899"/>
    <dbReference type="eggNOG" id="ENOG502RFXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101047_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDE2"/>
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    <dbReference type="OrthoDB" id="4502478at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="174" mass="19769" checksum="EBCBC22828E40D7F" modified="2011-10-19" version="1">MAPLVPSLAQSESKQKFFARLGLNPSDPVHKRVYALMKMEAAQARRRLLESQTSSTAQIHESAWQREVMRVYDDACIETKAVYNFGHDTENRIRPDNWIIRWLLWHVFRYRDYRNKGRPGNAPDGSSGEGDADSTPSDSPTPHGDTSSSDSKTGKESAGGSKRYWDPIREQWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDG8</accession>
    <name>F9XDG8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-strand-break repair protein rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_43283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851828.1">
        <property type="nucleotide sequence ID" value="XM_003851780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDG8"/>
    <dbReference type="FunCoup" id="F9XDG8">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDG8"/>
    <dbReference type="GeneID" id="13402192"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43283"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.385"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDG8"/>
    <dbReference type="OMA" id="HTDLYEP"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="461"/>
        </location>
    </feature>
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            <end position="184"/>
        </location>
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        <location>
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            <end position="199"/>
        </location>
    </feature>
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            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68102" checksum="F424C26C8F90757E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE45</accession>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502RC91">
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="EGP86971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="56094" checksum="4ECD64066C0E3528" modified="2011-10-19" version="1">MATVMQHTATAITEATKLTTVDFATVKPLRSSRAANGIERSCIARDAMNLYGYIMAVGTYTRPWSSSECISHATIFKALKHCITQHHALCTIVEDADTEAPQLRQASLMDLTKHVVTFDAVDDDGPENTLQFLRNAHDLPLHSGHPQWRVIQLPIRSKTEDRILLAFVCSHAFIDGRSTFSFHQTFLQALQDIENIGFDSTPEFATPSNYTVPVAINDSGKLSISKELLQAAKQGPDTDTPFWKGSSTRPEYPGPKFPLYKLELFTISHALIQKSVLACRQQGSKLSALLDHVIARAISRALHRRGQHHTQFACFTPVDLRNTLQYDSNEWGNIVSSNLEVIEVGSTTLDREPLLGSEDWEKIKNTTDLLLQRSKTFVDHVTHLLSYLPSVQNWLLGCLKMPRNESFTLSNVGSFDAPKATDPSAWSIDDMRFSQHSYPAGPVFLFNFASTKNGPLNLTLTWWPGAIGVGDDSQELAFVREMCTDIVLFLESVARDWDDLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE76</accession>
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        <recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851723.1">
        <property type="nucleotide sequence ID" value="XM_003851675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE76"/>
    <dbReference type="STRING" id="336722.F9XE76"/>
    <dbReference type="GeneID" id="13401841"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_60336"/>
    <dbReference type="eggNOG" id="ENOG502RCV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_1_0_1"/>
    <dbReference type="InParanoid" id="F9XE76"/>
    <dbReference type="OMA" id="MTRQKFK"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF4">
        <property type="entry name" value="PRIMARY COMPONENT OF EISOSOMES (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34819" checksum="55421819234F521D" modified="2011-10-19" version="1">MLGRSHSKKKSTDGKHRFAISSFRGLGAPELSKKLRNLIKTQNHQIGAYEQAGRESQSLASQLSEWGESTEDDAVSDISDKLGVLLAEIAEQEDQFAQNLEESRGVLKQIRNVEASVQPTRTNKQKIQDELQKLKYKEPESTKIVTLEQELVRAEAQSLVADAQLTNVTRQKFKEAYDIHTAAVIERAEKQIILAQQARRLINMLDDTPIVPGEDRVAFTGADEGKEVLNDAETGLRGWSLNVDPIESNAGKIGNSGMGAPPQQEQSVTTVTTAGEGSVTSDQQRVEELERQQQEELASENPPYPTAEKTGNAALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFR1</accession>
    <name>F9XFR1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="InParanoid" id="F9XFR1"/>
    <dbReference type="OrthoDB" id="10400167at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="27678" checksum="1E52AC6C8708B8CF" modified="2011-10-19" version="1">MAPPKSNFLQKVRKQQKERRNLAGVRPESAFAALTAKNREVARRGNAAGGMAPLPVTADNNMAPVIPNLAIPTRAFNVLTCQHPNRIVTETENEDEGDGTAPPTYQDNTVSVDSVVDRVPPSAPSIITSTVAREGHPAGIRYDSAQPASPQPITHPAAKGPVEPTTRLVIARVPVVVLLRFKNLLTDEIVKHGVHFKLLEVQIEPGLETKRQVDARFDSVEDAATVKAALDGEMVDFIKLATEFVEGDAKDDCVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG26"/>
    <dbReference type="STRING" id="336722.F9XG26"/>
    <dbReference type="GeneID" id="13397836"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94555"/>
    <dbReference type="eggNOG" id="ENOG502RV56">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892004_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG26"/>
    <dbReference type="OMA" id="LRTDDYY"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391635" evidence="1">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="35851" checksum="B3FA618921576BC9" modified="2011-10-19" version="1">MHFITKLLVGAAAFCPTSVLASDLPAADLDAHLDLEARAYYKDVDRCQQDIKQSYGYQFCKTFLPPKTVVVKKTVYKYKGTRTICSTKTARFHLHRVQAGDDCSHDQDCNSCLFIYHYQNDDKGRGRFSRDDVPLHAFNDTILDTILDTILDTIDDTIDDTIDDTIDDTIHDTIHDTIDDTIDHSVDDTNHHPIDDPIYNSIDDPIYNSIDDPIYNSIDDPIYNSINHPIYNSIDDPIYNSIDDPIYNSIDDPIDNSIDHPIYNSIDHPIYNSIDHCVNHPVDYASNYNPHHDHRHDNSINLQFHFLLRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG66</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_105024</name>
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    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851316.1">
        <property type="nucleotide sequence ID" value="XM_003851268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG66"/>
    <dbReference type="GeneID" id="13401224"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105024"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.7.1"/>
    <dbReference type="eggNOG" id="ENOG502SA1F">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058677_2_0_1"/>
    <dbReference type="InParanoid" id="F9XG66"/>
    <dbReference type="OMA" id="QPHRRRM"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="46"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="243" mass="25762" checksum="1908A54E66027473" modified="2011-10-19" version="1">MADENNTNNNIPPTPSPPRSARRSSFAGETFANLFSSQRGSISRSPSDAHPPTAQQPTPSYPGPITTAAAQAQRRRLSLTTLGLSGSPNSTSPFGSYHSRRDSYVSSGTSEAIDESAIEEDSGGGGSGIPAQNPFGRRMSFGAKALRDVRTTSGTSPGQNNGTSTSGEGFNWSDNFRNRAERTASIAGGMTGVPPAPPAHLHQSRAKSVATMEPPATVMPKPKEQVRPDHFQERILKGDFYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGB8</accession>
    <name>F9XGB8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_61086</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851060.1">
        <property type="nucleotide sequence ID" value="XM_003851012.1"/>
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        <property type="project" value="InterPro"/>
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            <begin position="21"/>
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        </location>
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            <end position="82"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27647" checksum="2D03B0E764B6672D" modified="2011-10-19" version="1">MPSHVAEALLRHHPLQRLESPSRGVSAAFHLAGLTSFAYPFSYLVRNPNPINDSYGWHMQYLTIIGLSLATLTFAAGLLADVTLSRRLFRIKNALSVASAPLEVLISILYWGLRVINPALVEPEWAAPLALIDDMSFHGAPSSLLVLDLLFFSPPYAIAFLPAFGLSAAIAFGYWFWIERCYQFNKFYPYPIFELLDTPGRIGLFAFSALLMTASTTLLIWLYGVVNGQERQGAVQGDVHKGRSGNVKGK</sequence>
</entry>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EGP86035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="55" mass="6499" checksum="4A413F2E44B67776" modified="2011-10-19" version="1">MHHHPQNQERALNLSILLVSGPVKLSRRLHAWWCPSVNFFKFQPCDHTPPRTQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851261.1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="206" mass="23263" checksum="E338CDED5CD1A447" modified="2011-10-19" version="1">MAEAHPNDTGEFAHMLHVQQGILASFGNGSDIQETDQSNRLDLTTTEEHVTMQGFAEDEQHDDLVRSFRAEQRNQRLAKAAQEKREQERMAEASSDDSLDDDPQSLVSHQLRAKSRYGRLARSYRSKRKRDIANSDDAAESGKASKSFRCKHKAEGGETKAGDSKTLVDLELELAQNHRKACEAKLEILEAEKEELKLAIQRQKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGX3</accession>
    <name>F9XGX3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95022</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850461.1">
        <property type="nucleotide sequence ID" value="XM_003850413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGX3"/>
    <dbReference type="GeneID" id="13395039"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95022"/>
    <dbReference type="HOGENOM" id="CLU_1327318_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGX3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="207" mass="22825" checksum="261E4D50851672C6" modified="2011-10-19" version="1">MLFPANLTFQKRRVPAAGRSRSRRSRQVTRESHAAVMNPSVLADWVGRFARELDQCMRLLELSSREQDTSPDSTTITSPIYPTFAGADQHQRQAIQLSSITLHDPTAPTAQSSVIPIFRAMMSENEAVHDFCYDVPSTVITNHCISGVPVLVPCCIVHYQAARMLSGQCKSGSIDSTLVELTRAMHSRSRSLSPLSASKLHSSSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGY7</accession>
    <name>F9XGY7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_110384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849961.1">
        <property type="nucleotide sequence ID" value="XM_003849913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGY7"/>
    <dbReference type="STRING" id="336722.F9XGY7"/>
    <dbReference type="GeneID" id="13402755"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110384"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.218"/>
    <dbReference type="eggNOG" id="ENOG502RV4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918916_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGY7"/>
    <dbReference type="OMA" id="WRNRLGW"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33587" checksum="84C0046F210859C3" modified="2011-10-19" version="1">MMSNNNNNATNGPPRPSSPFQQPNARGRGNCKAQQVRPRMDRLVPGEPVGFDGEFQIVLREGAVKWKQRLAWVAVVNTKGESILDTFVVYDNEEGAEKRRGLPEFGVGKKDLLFKNGAVHASTVEKWLAEIFKDRPVVMRDQSGDTAAFEYETPFVHATIQDTQLLYSDRGERRSLKDVASEVLQRTIQVGGVHTPTEDAATTMELYLLKRPYDRAAEKAKLEANGLPTTSAHTRNGDRGRHNHRSRGGRGMGNGRGALQERAPNATATRGEQDWAGEAFVRPARGGQRRGRGRGGKKNELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHA2</accession>
    <name>F9XHA2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_75178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850230.1">
        <property type="nucleotide sequence ID" value="XM_003850182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHA2"/>
    <dbReference type="GeneID" id="13394528"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75178"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.698"/>
    <dbReference type="eggNOG" id="ENOG502SSF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072615_3_0_1"/>
    <dbReference type="InParanoid" id="F9XHA2"/>
    <dbReference type="OMA" id="WENFMAR"/>
    <dbReference type="OrthoDB" id="3650369at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="247" mass="27770" checksum="EDBEF138BEE73191" modified="2011-10-19" version="1">MADPNQAGPPHYGFSIRPRTSPSPRNPRISTHSSDADEIDRMLAKYGHKIWGFVIYRSTYASDSDWTECLRTFQSELKFDLEFLGGLDILDSNPFTIFEDRNLFDGASAAVVRDHFNAWALAAPEREQGTGAGGWGGSPRYNFCVQIDERCLRSILDGNHGGAQSEGFIKLIRGSWQSDPRADRLRASDPVQNLPAYDDIEGCTAYDIGWAKIRQEKYLAFFCALQNQNFWQSSYKRPPLVSSTDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XII6</accession>
    <name>F9XII6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Opi1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_74973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850307.1">
        <property type="nucleotide sequence ID" value="XM_003850259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XII6"/>
    <dbReference type="STRING" id="336722.F9XII6"/>
    <dbReference type="GeneID" id="13394378"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74973"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015714_2_0_1"/>
    <dbReference type="InParanoid" id="F9XII6"/>
    <dbReference type="OMA" id="YSPRFKY"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45830" checksum="F66EED3250768041" modified="2011-10-19" version="1">MTSPRGNGSAMGAEDRAARSTSVVSMEDPDVRMAAEALSGLGNPAFARSSQGQNMHISAHASPGMAGSAAHDPEPLLELIAQAHPWVGGTIKGSISAYSTTKHYSPRFVQYGYNLVERNITTPVVSAVSTVGGITGMDNGVRRYLEARRPTDLEHGAKDYNAMEIEHHTDGITRQGRDIITEQLPAYGASRPPSYREEASPASADRAMNRPSRNRSWSSQVFVTTSGLSVALSTTSRHSLRFCLNMLSHAFANVEHLTRALSIALNQYEGNRQHHLDGAALEKGPRPATPDQNENARRLANDIRHCCDQIMQTLKYVVDHVNNYAGGALPANAREFVRAQLMSLPQRWRLVSDGSQSTESDTSRHAQRMIAFATEGLDMMTQVSGVLKATLESAERWLERVGRRDQQEVDQTMHDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ42</accession>
    <name>F9XJ42_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_101149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849307.1">
        <property type="nucleotide sequence ID" value="XM_003849259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ42"/>
    <dbReference type="GeneID" id="13398928"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101149"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.116"/>
    <dbReference type="eggNOG" id="ENOG502RXBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030124_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ42"/>
    <dbReference type="OMA" id="LWKACSY"/>
    <dbReference type="OrthoDB" id="3629525at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="48303" checksum="E845F276CDF67EBA" modified="2011-10-19" version="1">MLNQYGLEWEGTLSGLEPRWTTDPDLPKIDEILRQHLNLDVTSKCAVQFFAQGGFNKLYSVSTDAGQWLMRVALPVDPQRKTASEVATMNFVRETTTTPIPSVRGHSATNENAVGFEWILMEMMPGMVLERKWRQMSMEQKEDLVKQLAQYQSQLFAAESRYQSIGNLYQPSSERYEVGSIVSMSFFWGDRGAQDSVNRGPFMTSHAWLSARLNLVLDSQAEILPNPDSDEDDIEDAEAIKALAERLLALLPSRFPADEVQSTMLFHDDLHANNILVSSEDPARITAILDWECVSFLPLWMACQPPALLEGRVRDKAPQRDIYAAHDPELDGPDEEDHAQGKTTLYWEHQLEYERGVLRPMFLQEMLRLQPAWMEVFRDGEAKREFELAVQHCDGLFTVRTVGRWVDEVEKGGESGSLREILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ80</accession>
    <name>F9XJ80_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_62211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849785.1">
        <property type="nucleotide sequence ID" value="XM_003849737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ80"/>
    <dbReference type="FunCoup" id="F9XJ80">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="13398945"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62211"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.153"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="InParanoid" id="F9XJ80"/>
    <dbReference type="OMA" id="YCDIHYD"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395644" description="Glycosyltransferase family 15 protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49708" checksum="922C05DDD5451BAA" modified="2011-10-19" version="1">MASSTKYLRFILLAIVCLILIVLFSSSSSSIPGGHHIQSAADILRAQGIWKGTGDRVASSNTFTQDVTDKEKIAIPQHNLPAFEDTTSPNPGAGKQLPVAAAPGERLNATFVTLARNSDVWEISRSIRQVEDRFNKAYNYDWVFLNDAEFDDQFKKVTTALTSGKARYGKIDEKHWSFPAFIDQDKAKRVREDMHERKIIYGDSISYRHMCRYESGFFFQHPLMLEYEWYWRVEPSIELYCDISYDPFKFMADNKKKYSFVLSLYEYVETIPTLWDSVKKFMTKHPEHITEGNAMAWLSPDGGETYNHCHFWSNFEIGNLNWLRSKAYTDYFNFLDTEGGFFYERWGDAPVHSIAAALMLKKEEIHFFNDIAYYHVPFTHCPTGEQIRIDNKCHCNPKDNFDWNGYSCTAKWYDVMNMPKPAGYEKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJB9</accession>
    <name>F9XJB9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MYCGRDRAFT_75707</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="23">CBS 115943 / IPO323</strain>
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    </reference>
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        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
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        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
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    <sequence length="757" mass="84504" checksum="AA99F0FA912A46B8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJM1</accession>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849479.1">
        <property type="nucleotide sequence ID" value="XM_003849431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJM1"/>
    <dbReference type="STRING" id="336722.F9XJM1"/>
    <dbReference type="GeneID" id="13402274"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101275"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.461"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="InParanoid" id="F9XJM1"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="370" mass="40793" checksum="4E28A119CA5C0238" modified="2011-10-19" version="1">MVAGSCLITGGTGYIGSFTALALLEADYKVVIVDNLYNSSAEVLNRIELICGKRPEYVQCDITDEKKLDEVFAAHPDIDNVIHFAALKAVGESGEIPLDYYHTNVYGTLCLLRSMKKHNVTNIVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGSTKFTVEMMITDFVNAERSNAKKAGTDGEKFNAALLRYFNPAGSHPSGVMGEDPQGVPYNLLPLLAQVAVGKREKLLVFGDDYDSKDGTAIRDYIHILDLARGHLVALNHLRSHHPGVRAWNLGTGKGSTVFEMINAFSSAVGRKLPYEVVGRRAGDVLNLTANATRANEELGWKTELTLEDACKDLWRWTENNPQGYRQEPPKEFVEALKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJN4</accession>
    <name>F9XJN4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_82188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849633.1">
        <property type="nucleotide sequence ID" value="XM_003849585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJN4"/>
    <dbReference type="GeneID" id="13402283"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82188"/>
    <dbReference type="HOGENOM" id="CLU_3093300_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJN4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="52" mass="6117" checksum="BABBE9DB3DC67F6D" modified="2011-10-19" version="1" fragment="single">MLRVRTRSRNLWRNTMLATRRTQLRISRAMRLLGSHNSSSRRLSKAMAVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJU9</accession>
    <name>F9XJU9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849275.1">
        <property type="nucleotide sequence ID" value="XM_003849227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJU9"/>
    <dbReference type="GeneID" id="13398807"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95514"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.47"/>
    <dbReference type="HOGENOM" id="CLU_2238755_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJU9"/>
    <dbReference type="OrthoDB" id="10572959at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="105" mass="11856" checksum="325405D9F9C7DC22" modified="2011-10-19" version="1">MPTIEELKANIATARAARDRAEMNLWDACKAHKTATKAKETVRKAQEWEVSPEWWKKNAFGLRRCRSRCVRDLILDRADSVPCAKQAEPAIITRYVAVPVDTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX2</accession>
    <name>F9XKX2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849002.1">
        <property type="nucleotide sequence ID" value="XM_003848954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX2"/>
    <dbReference type="GeneID" id="13398322"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96436"/>
    <dbReference type="eggNOG" id="ENOG502SI5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568840_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKX2"/>
    <dbReference type="OrthoDB" id="3632337at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395667" evidence="2">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="480" mass="52971" checksum="30C5AE15892B2CE2" modified="2011-10-19" version="1">MHLSAFDLVLILLAQALLTALPVGFTKPGSWIRSASVAVSTILMLISVFGRKDSYDCLTRMVLVFSPPALFLQNLNISLLRRWDFDYAGPQPREIGKREPSRPLPDSVWNRLAFGFSAATEYRHCGTPWEVENVPAFRKSDPKSVPSRREFLVRRGLLLLCIYLFMDLLGVLASQDVNKAPTELLPLFGRLEDFTMREVLDRLVFVVLFFVFGAASTTLHFGYGGYLLDDILHINEAGRWILAFRAVLDLSVGPWLLVVEVGAHDHIAQSLTRVPRFLLARTGNSTLDSRKEVPRMSLPAPHLPPTSRVDTARSAVAHDAEYFVFVLGCVTNSPQAWAIDLPWIWGNLAKSFRNHVSHTTPNHRWPPSKHSNLGTSIPDGSGCAIVFATTGEGTYDFAAFTNGTVLLSVEVHVGAPYYLPSPVSFHGYVYMDYNDDCRIYAARGYADVPSSVLNWLTPQAVGVPGGGLGSVCMPLPVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLB4</accession>
    <name>F9XLB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DOT2401</name>
        <name evidence="18" type="ORF">MYCGRDRAFT_23780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849191.1">
        <property type="nucleotide sequence ID" value="XM_003849143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLB4"/>
    <dbReference type="FunCoup" id="F9XLB4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLB4"/>
    <dbReference type="GeneID" id="13398738"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23780"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027287_2_0_1"/>
    <dbReference type="InParanoid" id="F9XLB4"/>
    <dbReference type="OMA" id="VQQKNYW"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="17">
        <location>
            <begin position="84"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="296"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP84167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="401" mass="45906" checksum="DCF61E6817B1E659" modified="2011-10-19" version="1" fragment="single">SNDTEGSESDASRKRLKSSPSSVDSRPPRASLLSKEAFAEEAVIDIIHGADVTSGEHKDKFKNPWEDEDFQTVSLQYPSRSQQERFELKFPIQAEDYKPMEDITETIKTICTYYFPAELATKYSHDEAGYARRFNRAWQRQSVEDFIEVINDFNTTLQDLLSDGSIQTRLSGHRNIDLEWIQRIIDQIYARTVSWKVETLRRYENFSNNVYGELLPRFCSEIFQKTGLNHKQIFVDLGSGVGNVVLQAALEIGCESWGIEMMDNPCELAALQAREFPARTRLWGLSVGEVHLLKGDFTKNEEILEVLKRADVVLVNNQAFDPALNDTLRDMFLDLKDGCRVASLKPFVPVGHKMAMRNIDSVVNQFTQQKFEYWSDSVSWGADHGEYFVATKDPRPARAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLE2</accession>
    <name>F9XLE2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vps52-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_76401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848900.1">
        <property type="nucleotide sequence ID" value="XM_003848852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLE2"/>
    <dbReference type="FunCoup" id="F9XLE2">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLE2"/>
    <dbReference type="GeneID" id="13398500"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76401"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.335"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="InParanoid" id="F9XLE2"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="8">
        <location>
            <begin position="156"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="9">
        <location>
            <begin position="344"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73391" checksum="EC9D7CCAA8DF6715" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLE7</accession>
    <name>F9XLE7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Translocase of outer mitochondrial membrane complex, subunit TOM41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_111073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848902.1">
        <property type="nucleotide sequence ID" value="XM_003848854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLE7"/>
    <dbReference type="FunCoup" id="F9XLE7">
        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLE7"/>
    <dbReference type="GeneID" id="13398497"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111073"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.340"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLE7"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="375" mass="40129" checksum="0127BBC5637240DB" modified="2011-10-19" version="1">MATTVPLEKTAVPVPVEVEFPPQDVTLPSVRTGGFLDTVLDTYQSFQARRDALGLSNPGTVDQIAKEVQRDVFLTNQIFSGLRAELNKTFSILPLFQISHAFSSGSQMLSPYTFLALYGTNNMLCQAQLDSDGSLNARFNGRITSRLINKLAVQIQPGSMAGPGGAQVSLEQDYTGDDFTASLKSINPSVLEGGLTGMFIGSYLQSVTPRLSLGIEGVLQKPGGGMGPEVAMSYAGRYKGDDWIASAQLLTQGGMQVSYWRRLMDKVETGVDVNLQFAGLSGGNPMMGAARAEGVATLGAKYEFSRSIFRAQVDSQGKLGCLLEKVVAPPVRITFAGELDHVKNSAKLGLAVSIEASSEELMEQQERISGAIPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLK1</accession>
    <name>F9XLK1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849175.1">
        <property type="nucleotide sequence ID" value="XM_003849127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLK1"/>
    <dbReference type="GeneID" id="13397985"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96134"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.168"/>
    <dbReference type="HOGENOM" id="CLU_1355611_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLK1"/>
    <dbReference type="OMA" id="REVITPM"/>
    <dbReference type="OrthoDB" id="10502197at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="202" mass="21506" checksum="B7D9974CDC1390F1" modified="2011-10-19" version="1">MGMNPFFGGQPFLPQNMISPAFGFGGMGGFGNGGGLQGWGGGLGGGFGGGGQYDVYDMVALGLWDAYDLEEYLEQMSQEASMQGIQIGADMQQYRDLVQMARQQQQQQQQVNVFMPGGGHGRGQGRARDQRYWKQLARGGGGGGMWGGMGGGWRGGWGGGWGGNGPRRGMGWNGVNRPGQLRVTGSPSPYNVPFNLRLTRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLW5</accession>
    <name>F9XLW5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849044.1">
        <property type="nucleotide sequence ID" value="XM_003848996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLW5"/>
    <dbReference type="GeneID" id="13398441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96367"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.461"/>
    <dbReference type="HOGENOM" id="CLU_1267787_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLW5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24612" checksum="24FE4DA2A102E6A8" modified="2011-10-19" version="1">MDNTADISHLWESEEYSDLVIKCLGCTWTVHKCIVLPKSKLLRDAANRSDEVDSKGRLVIDVDCFHWGGLDLILRSMYDSVGSENRLSACCRAQTLTAVHELARREGLIELQAQACRAMLRFSKDKTNMRNFKDVVDAMRKMGGPKMLAVADELELVWVPKALVDPKNREKLSAEAVQRYINSVEPRKKGKRSAEDALEHNSPPPAYRTASDSHELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM15</accession>
    <name>F9XM15_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="4">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_88098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="4"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848552.1">
        <property type="nucleotide sequence ID" value="XM_003848504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM15"/>
    <dbReference type="STRING" id="336722.F9XM15"/>
    <dbReference type="GeneID" id="13396180"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88098"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_4_1"/>
    <dbReference type="InParanoid" id="F9XM15"/>
    <dbReference type="OMA" id="WMTRDIA"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
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        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="176" mass="19720" checksum="3414D95140D5FB7C" modified="2011-10-19" version="1">MLECIGEDPNRKDLLETPRRYAQALIDLTSGYKLDTHAIVGEALFHGAYTGMVVVKDIEVHSLCEHHLLPFLGKIHIAYIPNSTVIGLSKVPRIVQMYSHRLQIQERLTSQVAYAVQDVVKAKGVAVVMEASHLCMKMRGVEQTDATTVTSCFMGCFDEKPELRSEFLRYVGVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMB4</accession>
    <name>F9XMB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848497.1">
        <property type="nucleotide sequence ID" value="XM_003848449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMB4"/>
    <dbReference type="STRING" id="336722.F9XMB4"/>
    <dbReference type="GeneID" id="13396217"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96851"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.508"/>
    <dbReference type="eggNOG" id="ENOG502RV5G">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="F9XMB4"/>
    <dbReference type="OMA" id="ATERHEH"/>
    <dbReference type="OrthoDB" id="3650724at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="46"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="653" mass="73660" checksum="ED9730E84580EC98" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN14</accession>
    <name>F9XN14_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_96640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN14"/>
    <dbReference type="FunCoup" id="F9XN14">
        <property type="interactions" value="1064"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN14"/>
    <dbReference type="GeneID" id="13396142"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96640"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.241"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="InParanoid" id="F9XN14"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122869" checksum="6F99E405377478C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNA0</accession>
    <name>F9XNA0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_76950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848575.1">
        <property type="nucleotide sequence ID" value="XM_003848527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNA0"/>
    <dbReference type="FunCoup" id="F9XNA0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNA0"/>
    <dbReference type="GeneID" id="13396498"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76950"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNA0"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="4">
        <location>
            <begin position="519"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="980" mass="106084" checksum="AEE70607C096D2C2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNA5</accession>
    <name>F9XNA5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848573.1">
        <property type="nucleotide sequence ID" value="XM_003848525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNA5"/>
    <dbReference type="GeneID" id="13396419"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106161"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.348"/>
    <dbReference type="eggNOG" id="ENOG502S78C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065192_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNA5"/>
    <dbReference type="OMA" id="KFPMTWP"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34194" checksum="54045F66D4AAF99E" modified="2011-10-19" version="1" fragment="single">MAMCLSAGRGARWQRLTPNPATSLRNLLVCSLEQQRYSTTKAASSAKPATASLSPRWLSDVKQRIGHCITFGLKPDQTDDAGHILKEIARDWRELVAGSEGFLTDKTRLSMYRREVIWGEMDSMGHVNNVVYNRYAESGRIGWAQKYARHIDPEHAEQWRDLMTPKGEGLLLRKITTEFKFPMVYPDHVTIYHKLSSRPEEGTDNFDMHVIILSELHQRPAARLIEDCVLYDYRRAKKTPLQPWMLKVLQKTWDLQEEAKRVNSQRVHSILDRVRKLETDSWDREDAVEDMGSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNN9</accession>
    <name>F9XNN9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847929.1">
        <property type="nucleotide sequence ID" value="XM_003847881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNN9"/>
    <dbReference type="GeneID" id="13401799"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106345"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.189"/>
    <dbReference type="eggNOG" id="ENOG502S1X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110345_1_1_1"/>
    <dbReference type="InParanoid" id="F9XNN9"/>
    <dbReference type="OMA" id="DSKAICG"/>
    <dbReference type="OrthoDB" id="3650170at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390941" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="163" mass="16217" checksum="C452D1D2C1AE6C7E" modified="2011-10-19" version="1">MFTTKLTTLALLTASLANLTFAAPPACVIGAVNTQSNPHDIAAVCKAQEVQDSITKNCGNAQEAAQKYFSEVCKDAGVTVSATVQNDDSNSSSSNSSSSSSSSSSDDGMIPTGTSSATNEAQATRSSSSGSEANPTATGGAARVGLEVVGLMAVGLFGTLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNZ8</accession>
    <name>F9XNZ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_77528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848105.1">
        <property type="nucleotide sequence ID" value="XM_003848057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNZ8"/>
    <dbReference type="FunCoup" id="F9XNZ8">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNZ8"/>
    <dbReference type="GeneID" id="13401974"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77528"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.309"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="InParanoid" id="F9XNZ8"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="PHI-base" id="PHI:8592"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="414" mass="44605" checksum="749B7048085D6AF3" modified="2011-10-19" version="1">MLARVAPMSRSPASLPCRGMRRADPLILSSQPRVLQLFKPASRLALLTNHRQELALKGRLPSHVRESLRFVSTTITPSSKKASENDKVSPYSPPTTGLLSYLPSSVVPYAELIRLDKPVGTYYLFLPCLFSTLLAAPLASPIAPPVTVVSTAAIFFFGALIMRGAGCTINDLWDRNLDKNVARTRLRPLARGALTPKQAVPYLGLQMFSGLALLLQLPAACFWYAVPSLPLVAAYPLAKRVTNYPQFVLGLTFSWGAMVGFPALGIDLLSNNPAFISAACLYSSCVAWTVVYDMIYAYQDIRDDAKAGIKSIALAQEANAKMFLSAVGTLQVGLLAAAGVAVGAGPAYFVGAVGGAASTLGYMIWKVNLSDVVDCWAWFRKGAWFTGGAISTGLAAEYMVRYLSEENEQEKSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP29</accession>
    <name>F9XP29_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_50578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848001.1">
        <property type="nucleotide sequence ID" value="XM_003847953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP29"/>
    <dbReference type="FunCoup" id="F9XP29">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP29"/>
    <dbReference type="GeneID" id="13402128"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50578"/>
    <dbReference type="eggNOG" id="ENOG502RXY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032651_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP29"/>
    <dbReference type="OMA" id="RLVMMEL"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33823" checksum="02A0007281EF2C6D" modified="2011-10-19" version="1">MTARLAPFTKLLPELSTALKTFQASSSRFQVLKTVHPSSFEPINPTRPSDSESPKTLFILDSSFNPPSTAHLHLARSVLSESTSPKPHRLLLCFSTQNADKAPSAASFPHRLTMMTIFAQDLLKSITDSTGTSSAEPVPIDIGVTKAPYYTDKSSAIESDGAEWYPSKPRHIHLVGFDTLTRFFAAKYYQDFDPPLSALEPYFSAGHHLRVTLRPDEKYGTVEEQRAFLKNMEDGGLESVGGKREWAKAVQLVEPNEEGGVSSTKIRTAAKEERWEVVDGLCTEGVAGWVRREGLYEEDAEGKKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPC3</accession>
    <name>F9XPC3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_77156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848251.1">
        <property type="nucleotide sequence ID" value="XM_003848203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPC3"/>
    <dbReference type="STRING" id="336722.F9XPC3"/>
    <dbReference type="GeneID" id="13401917"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77156"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.5"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_1_1_1"/>
    <dbReference type="InParanoid" id="F9XPC3"/>
    <dbReference type="OMA" id="MRGVRSI"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="428" mass="47749" checksum="40F1A7F4D7FDB9AA" modified="2011-10-19" version="1">MIETTHDPPHDKNHGLSRRTHRKSRAGCIECKRRRIKCDEVKPSCGNCVRRTVTCRFRSNAPATRSEDASAATTPSQHTDPTIVQLSFDSTISTPTAHLIPSTASTPPIPSAAGVEIPNLFHLELWHHWLTTACLTFSDDDNRVGMWRETVPQLAVRHSYVAQLLLALSALHLARLQTVRRALCMATSTALQSSAIDGMIDGLAASPDSDRTSSLFIAATLLCFCNLAKGPQDGQYLLYADTAEPEWLGLLQGVKSILAEHRHVLADLSDEDGRAGDVEESVGPDLALSGFSASFDKLKTSIESLRAEDESFAKYSRPVDDLQKCFDSAFWRQQGSDVIRVHSPAVFGWLYRLNAEYLKALQDGKPMALVIYAYYMVLFARLDRFWFVEGWVDHIMVDIQRRLHHTYKHWMEWPCLLAQPAESQSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM7</accession>
    <name>F9XPM7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847826.1">
        <property type="nucleotide sequence ID" value="XM_003847778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM7"/>
    <dbReference type="GeneID" id="13400816"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97259"/>
    <dbReference type="HOGENOM" id="CLU_1416192_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPM7"/>
    <dbReference type="OrthoDB" id="10390099at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="20861" checksum="01913ECD364B79F4" modified="2011-10-19" version="1">MAPKARAPAPKRPAKSNHRAPKPKGPHAASTALRNIPTEPTANPNPTTKPSVPKFDPNTNIGKAVRFQAQVEKAKKARARELEPSKRPLPPPDEFDLEAVEQETKARKVAMRARTANMGGRVVRGEDEVAGAFIVEQTVPGSKSDMWARYHKQQRGGGEVVRNDARAKGPGVESVLKAQGGGFQPLRWEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQP2</accession>
    <name>F9XQP2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_51670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="OTU_Deubiquitinase"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847277.1">
        <property type="nucleotide sequence ID" value="XM_003847229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR88"/>
    <dbReference type="GeneID" id="13399893"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97747"/>
    <dbReference type="HOGENOM" id="CLU_1939767_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR88"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="130" mass="14166" checksum="CDC912BC379B90B0" modified="2011-10-19" version="1">MSSLKREGPKAQGIEMENGTCATYCAVQLSPRTVQSSRVRLHGISRSFTGSRKGRRGRSEEDDYGDSPEAGSPLLDLDVLQEIREHNFGKTGSDATPEAAITESIATLLHPTMARVLIHMNTCRVPAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWB3</accession>
    <name>F9WWB3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase protein x component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_34965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856084.1">
        <property type="nucleotide sequence ID" value="XM_003856036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWB3"/>
    <dbReference type="FunCoup" id="F9WWB3">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWB3"/>
    <dbReference type="GeneID" id="13403132"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34965"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_0_1"/>
    <dbReference type="InParanoid" id="F9WWB3"/>
    <dbReference type="OMA" id="DGIMMKI"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="44624" checksum="4BA4F3D3ED47DCD1" modified="2011-10-19" version="1">MPGFQASACNCAATNYTMPALSPTMTEGSIASWRVKEGDSFSAGDVILEIETDKATMDVEAQDDGKLVKIVKGDGSKAIQVGERIGILADPEDDISTLELPAEDSKPAKEEKSAKKEEKSAAKEENKRESAPKPEKSSESKEASKSSELQKQGGAARKQTYPLYPSVEHLLHVNGLSAEDANQIPASGPQGRLLKGDVLAYLGQVQKSYPASISARLDKLSHLDLSNIQLAKKAEAKPENKQAEQKTEPELPRETEIAIPISLSSVIATQKRVQDTLGIFLPLSTFIARASELANDNLPFSKTHKATADDLFNAVLGLDKVATSSRGNYFPNITGLSSPSSITAAPRSAKKSDIIDLLVPKPKAPKRAPAPVMPGISPRENIFSVVARNGEESRATEYLEKMKLVLEDQPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWL1</accession>
    <name>F9WWL1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857310.1">
        <property type="nucleotide sequence ID" value="XM_003857262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWL1"/>
    <dbReference type="GeneID" id="13402881"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89510"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1104"/>
    <dbReference type="eggNOG" id="ENOG502R8A3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171062_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWL1"/>
    <dbReference type="OMA" id="EEFDHAE"/>
    <dbReference type="OrthoDB" id="10499434at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="26606" checksum="B452658A0AC6095E" modified="2011-10-19" version="1">MPGVPPDAVERVKGLAKRTLKGFFSKRNKDKPQAQQQQQPAAQQTAAPAADTPPPPPPPAKPVEQTPTQTSTPAITTTTNTLTAAAAAANPPNTGKELPPAGPQTTTAAKDAATTKDTSTLPATAAATTSDVKQDKVSPATSAAAGNSEPVSAVDETPPALPPKNDGSAAVLKQIETPPAEQHTPAAAPATTTEAPKSVSALDGTSSTAPTSDSTTAKPNEPSTVTAPLTLTPATAPTAAIPAAADKSAGGMSATSGPLEDFPLGAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWQ8</accession>
    <name>F9WWQ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_33254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856492.1">
        <property type="nucleotide sequence ID" value="XM_003856444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWQ8"/>
    <dbReference type="STRING" id="336722.F9WWQ8"/>
    <dbReference type="GeneID" id="13399115"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33254"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1385"/>
    <dbReference type="eggNOG" id="ENOG502SHXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9WWQ8"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395170" description="AA9 family lytic polysaccharide monooxygenase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="320" mass="33779" checksum="100965653A5A0D4A" modified="2011-10-19" version="1">MHPTHTLFLLGSLALTPIIQAHYIFSQLLVNDTPIGQDYTYVRKNTNTYMPSFTSEVISSPDAICNKGAHTMSSQTLTVKAGDKVGFKLAYNELIEHPSPGFIYMSKAPGDVNDYKGDGDWFKVWESGVNGPANVDTNWGTWQKPSMTFTIPKDLPDGEYLVRPEHIAIHEAHVGKAQFYMECAQLSVSGGGNGTPGPLVKIPGLYSAEDPGIAYNIWTDNPAPYVMPGPKVWSGRVSSGSNGGDSTSPAETPAETGTGAGNGNGNGGSSSSSASTAGFGSTSTHSPAFPTTFASPGNVPPGPGRWMGGWNSRVKGRSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWZ0</accession>
    <name>F9WWZ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857061.1">
        <property type="nucleotide sequence ID" value="XM_003857013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWZ0"/>
    <dbReference type="STRING" id="336722.F9WWZ0"/>
    <dbReference type="GeneID" id="13395406"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102821"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1641"/>
    <dbReference type="eggNOG" id="ENOG502SI58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_1_1"/>
    <dbReference type="InParanoid" id="F9WWZ0"/>
    <dbReference type="OMA" id="DDGHIIW"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395177" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70548" checksum="2BFE8BC9796B354F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102020"/>
    <dbReference type="HOGENOM" id="CLU_2869382_0_0_1"/>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90875.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="64" mass="7117" checksum="949DD4C3F1385A49" modified="2011-10-19" version="1">MYMKPSASISTSTSTSTSPSRTIKNHFPSVFEAATSVLGMPIQKNEERSEMLDVAHRRSRSLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="OMA" id="NFRCNEP"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP92514.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="499" mass="57063" checksum="7D77F2B826D83DF0" modified="2011-10-19" version="1">MQTYRNYQANQHATSARRGPGPMVAPPQAHAGQPALTPAQIQAQHLEALRRHDLARRQAKKPTDRDIPDEISEAVVGDGVERYRKLREVERKLDAAMMRKRLDISDNLQRRYTRKEGILRVWISNTVEGQPWQALEDGIGNDDGMFELGENQATYRVKIEGRLLDDSEEEEDDKPATAHRPRLSSFFKAITIDFDRNPNLQPDGTSQIEWRKPQPGPQNPNYDANSAEAAFDTLEFTRKSDEPINVTINLVRDEKSERFRLSPELAEILDTEEEDRAGAVQGVWEYCRAMGLQEDDDKRKIICDEPLKRLFKADQVYFPYVPDHLQHHLHPLPPIQLQYTIRVDKPYITGTPNPELDAEDEDSTEMKPCRPTVYDIRVPLPNPLHHQLTRFHTSKAHIGDLQTIVNTDDDLALLVQKIHQTNAKRKFYDNLAKDPTSFIKRWVSSQQRDLEVILAEATRGGGEDANGEEFRRGGKEGVWGTDLAKESVGLWLARNTKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91237.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="488" mass="50078" checksum="3C890B1AA9875197" modified="2011-10-19" version="1">MHAAVEQNHELRDTILRFIDCMAAPHRIEVHDKRQKYLSSGSCCALWTFRSCPAAMLLGPVVCQVETTLQSPPSLAAANFCDAPSHAVLLKPQPRLKFRGATTALIRFPRHFVVRPRAGLHSSQVQRHIRIPTLEMPSIRSILLVGLPLAALCQELFDSRRAADVQRHGIVGAGRNAIERAVDMAGGELDSERYLGKRQDSNGTVAATVTVSDVVTATVSSSPTPDTTTSSSSSQETIISVPTTLVSVPITTEQPSGTTSTEAPSFSAAASSSELGSSSIAAPSSSAEPSSTPPVVDTTASEPAPETSSSPASQPSSTPASNSPSSSAVLPTTTAALPSRTTFAVINSAGSVVTSVPQVATVSDASGEGIVLTSPTPGGVYTNTKSGGDVAVVTYTPDGGTVSEVRYLTETLPNGSASIRTSYATVGAPASPTAGGSSNSGSGSDAPQLQSGAAISSTWYAAEAAVMLGAAVGVAAMMLWRLMAELNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY78</accession>
    <name>F9WY78_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_84013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856517.1">
        <property type="nucleotide sequence ID" value="XM_003856469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY78"/>
    <dbReference type="STRING" id="336722.F9WY78"/>
    <dbReference type="GeneID" id="13399020"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84013"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY78"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="234" mass="27319" checksum="B93D98B0D34CBE8A" modified="2011-10-19" version="1">MADTLPTIDFNFNDLRERMQQFTVRFDDFIERGRKKVLEERNAFRMNIADQADQQRQRKQAITELESKSSSHAHIIAKETQETDEMHEAIRSLTSQKEEHVARRDQLKTEIASTQSAIRQLRDAQAAHQRSLDAQAKHNVPELRFWETCLGMRLDGTGVDDRLKFVFVSIDDRDTERECWFELNIDGSRYEVASTKPRLNRDDVDAVQDRLNESNDLGPFLKTMRAMFVEVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY94</accession>
    <name>F9WY94_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_66795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856526.1">
        <property type="nucleotide sequence ID" value="XM_003856478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY94"/>
    <dbReference type="STRING" id="336722.F9WY94"/>
    <dbReference type="GeneID" id="13399013"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66795"/>
    <dbReference type="eggNOG" id="ENOG502SF32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY94"/>
    <dbReference type="OMA" id="TPEEWWV"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391009" evidence="2">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="250" mass="26815" checksum="0E2EDBD78C454F47" modified="2011-10-19" version="1">MRVSTFVLALPALAAAQQQIPLVDQVKGWFAKATESLNAVVSSASESVSVKVPNPVASGAAKVATLKVERIGLDNHNEVIKPDNPSSSTGIETWLVYVHGGNKTCFGMCGSAETAFNESVVLLAASPNPPKLARMDCETDPVLCNAWAISPPQIVHIQLPQPLADQSTPATTVRSIPLNRTTVAATQIAAIHLEDKYLETTPYEGLFHPFDGQLAKLGLNIPFGYLMWGFSLVPSWALMIGISFISRTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYN1</accession>
    <name>F9WYN1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_67374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
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    <sequence length="708" mass="75642" checksum="F1A4ABD6757EA8DC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="240" mass="25439" checksum="FD16AD17F6FCADDF" modified="2011-10-19" version="1">MHAAMVNRSIRTIKAELEYLCDASVISPQTLSELLSKVPAQTALHAPISVGAVPSAVNGPVSHAPTPVPNASMNNLSLNNHNQPQANSNGYYDEKAQHEQAPPAYNAPPPVANYPPLAQATALYPYNSTDAGDLELQPNDHITVTEYMNAEWWKGRSSRTGQEGIFPRSYVKVVEEKAAASSTTNNYGNMPLEISGQGNGEGKVPGKAEQQGKKFGKKLGNAAIFGAGATIGGNIVNSIF</sequence>
</entry>
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        <recommendedName>
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        </recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
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                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003857475.1"/>
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    <dbReference type="AlphaFoldDB" id="F9WYZ8"/>
    <dbReference type="GeneID" id="13394456"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33479"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.635"/>
    <dbReference type="eggNOG" id="ENOG502S16N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132815_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYZ8"/>
    <dbReference type="OMA" id="AYFWAYS"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="146" mass="16669" checksum="41A4BDAAA5304645" modified="2011-10-19" version="1">MGKLIKNHWARLICLTAASYQIAAALEGFFWPKFFFDWLTKNFDGAVKPVPTLQTINLIFGLLGLAYEWPLKIVAGTAIHRSMEVRLMWIPLASLSSLLLYQATNAALYYFIGCMVYFWAYSEGEVICAVPWTLPKRADRRRAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZA8</accession>
    <name>F9WZA8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856405.1">
        <property type="nucleotide sequence ID" value="XM_003856357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZA8"/>
    <dbReference type="STRING" id="336722.F9WZA8"/>
    <dbReference type="GeneID" id="13402830"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89592"/>
    <dbReference type="eggNOG" id="ENOG502STPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185831_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZA8"/>
    <dbReference type="OrthoDB" id="5296720at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="234" mass="26461" checksum="79DC13B2FBD0AFBF" modified="2011-10-19" version="1">MPIDSLPEELLLSIFSHFDTSSPSELKSRQEPSLNLTLSDVHPLKDISLVSHRWRRIVLSLLFRYTRFHLKTPTNRPSCSLCTSTFLLPSDHEPVVHTSESARFFHARINQESKTWYHSDDTAPAIQDLPWINYVYHAVTSLLSFICSRGLAPHVYSFAVCSPRLLHLAQLGHGLAEEDPRYRVTTAFWREVFEVLVPSRVVVLAPPGDLAVWTGLGGVALETTWVSLTLMLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZC5</accession>
    <name>F9WZC5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgPRM1</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_21413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857250.1">
        <property type="nucleotide sequence ID" value="XM_003857202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZC5"/>
    <dbReference type="FunCoup" id="F9WZC5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZC5"/>
    <dbReference type="GeneID" id="13402821"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21413"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZC5"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP92226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="595" mass="64951" checksum="CC2CB502E31161B4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZW5</accession>
    <name>F9WZW5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caib baif family enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_65466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856067.1">
        <property type="nucleotide sequence ID" value="XM_003856019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZW5"/>
    <dbReference type="STRING" id="336722.F9WZW5"/>
    <dbReference type="GeneID" id="13403149"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91043.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="580" mass="64667" checksum="CA2A5BF126E72482" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZX2</accession>
    <name>F9WZX2_ZYMTI</name>
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            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP92474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857498.1">
        <property type="nucleotide sequence ID" value="XM_003857450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZX2"/>
    <dbReference type="FunCoup" id="F9WZX2">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZX2"/>
    <dbReference type="GeneID" id="13403069"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98375"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.695"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vacuolar calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNARE"/>
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    <dbReference type="InterPro" id="IPR007705">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP92474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="224" mass="25399" checksum="404B873DE8303F5D" modified="2011-10-19" version="1">MANPLDTDAGSELFSNYEAELKLVQADLSQKLDQIPELSGEQRKAAVSQADRALEEAKELIESMRLEKQNIPQALKIKVNQRFRNYQTDVDAAGRKLKGMQDDRSALFGKRYTDNPQDEQLEQRQQLLGGTERLERSSGRLRESQRIANETEDIGRNTLGDLARQRETIEHTRTTLLQSEGYTDRSNKTLKGMARRMATNKIITVAIIAVLVILILAVIISKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0H2</accession>
    <name>F9X0H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_102763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857115.1">
        <property type="nucleotide sequence ID" value="XM_003857067.1"/>
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    <sequence length="377" mass="42046" checksum="A378C157552E0A4D" modified="2011-10-19" version="1">MFALRRVAVRAISQQPSRQFSAIKSVPRISPFQTQKPSVYRSFHQSLRWAAEEDKKEASPAEAQDPSETVTVEPSAEEQAAEIKEESIATPEVADAAGSSTTENNSATETVKEYASDAAETVQEYASDAAETVKDAAASVAQTFSSPPQERTERGERPQRSDRGDRGERTPRAPRQWEDRSEGNPPSKILYVGNLFFEVTAPKLEAAFGRFGEVVSSKVVTDARGLSKGFAFVEFSDQEAANRAKQELNHTEFEGRRLSVQYHLKKDRREGGFSPREGGTRNKPSKTLFIGNMSYQMSDRDLNDLFKEVRNVLDVRVAIDRRSGQPRGFAHADFIDMESAKKAKELLEQKSVYGRQLRIDYSRDSGDNKSNSSPFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Q3</accession>
    <name>F9X0Q3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_67398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
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        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113741" checksum="F36ADEDD4526A03C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1A3</accession>
    <name>F9X1A3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856482.1">
        <property type="nucleotide sequence ID" value="XM_003856434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1A3"/>
    <dbReference type="GeneID" id="13399120"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89719"/>
    <dbReference type="HOGENOM" id="CLU_325769_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1A3"/>
    <dbReference type="OrthoDB" id="4788824at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="885" mass="98633" checksum="91C05B9A9047DD3C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1K4</accession>
    <name>F9X1K4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_33131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856783.1">
        <property type="nucleotide sequence ID" value="XM_003856735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1K4"/>
    <dbReference type="GeneID" id="13398265"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33131"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1999"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_5_0_1"/>
    <dbReference type="InParanoid" id="F9X1K4"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395271" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="87"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="411" mass="44299" checksum="D936AF466C5ACEEC" modified="2011-10-19" version="1">MRSTLLLLESLALTATAFPWAAKLANSDISALQSPSLVKRADVCPVNRPRKGAAPYNEYYPSKYTGARNGQPGTGKGGVQVPAPGDTAHAYEAPSSTDIRGPCPGLNMAANHHFISHDGQTTYNEMVDFAQNVFNWRYDLAAFVATFGIVQDGNVLTGELSIGCNGGQQVPNTGLNTHDKFEADSSITRTDYYLSPNGDNYGVNETLFNYWNDFCNGDFTLECMGPYMRSRYDQSLHTNGNFFNGPLFLFALGTAALPFQSFASYGNEGTPSVSTIAPFWAATRTSTGHYTVAPGTERLPSYWYNRPTSLSFPEIVGQVSDLYQAAGSPAFGGNTGKPDSFVGLEFPQGGIEGGVLKNSTPQGVACLFYQLVTDFIPLSLDNQVLQLSKVSQIFAKSKLTSVFANFGCPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2M6</accession>
    <name>F9X2M6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854741.1">
        <property type="nucleotide sequence ID" value="XM_003854693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2M6"/>
    <dbReference type="STRING" id="336722.F9X2M6"/>
    <dbReference type="GeneID" id="13403716"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28587"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090382_0_1_1"/>
    <dbReference type="InParanoid" id="F9X2M6"/>
    <dbReference type="OMA" id="FTDMFPI"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP89953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="463" mass="51772" checksum="9CFAE36430EB2E37" modified="2011-10-19" version="1">MSTLEDLDDLERDGKKEENNDGDKGKKPDANGDSEMKESKDGEKEEEEEQLIDLEILNSSTRDIIARRRLLENDTRIMRSEYQRLTHEKQTMHEKIKDNVDKIDNNRQLPYLVGNVVEILDLDVEEEAAEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDHEKLKPGDLIGVNKDSYLILDTLPAEYDSRVKAMEVDEKPTEKYTDVGGLDKQIEELVEAVVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTDATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSDKSGDREVQRTMLELLNQLDGFASDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILRIHSRKMTVDEGVNWPELARSTDEFGGAQLKAVCVEAGMIALRNGHSKISHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4X7</accession>
    <name>F9X4X7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_36641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855211.1">
        <property type="nucleotide sequence ID" value="XM_003855163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4X7"/>
    <dbReference type="GeneID" id="13400304"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36641"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1211"/>
    <dbReference type="eggNOG" id="ENOG502R8N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090697_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4X7"/>
    <dbReference type="OMA" id="PDCRGCK"/>
    <dbReference type="OrthoDB" id="3838383at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="186" mass="20794" checksum="140E20BEE815CBC8" modified="2011-10-19" version="1">MFETTFTHSSTATLPHPTSMSHALSLLHDFNTVIHLSPECNGFRAIPSPVPNQKDDHIQHYEVEDQLHFLPRYLWSGNVKYTADFLPQHDGCDITVHAPGGLTSHTRWRLTREAVVAETGQAGSENKEFAKDLTDEDGTGVWYVQIVSEAACSLTYANFVKGFLKDSHQKLLEAYVEKVKEGPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X567</accession>
    <name>F9X567_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_108776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853997.1">
        <property type="nucleotide sequence ID" value="XM_003853949.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X567"/>
    <dbReference type="GeneID" id="13395470"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108776"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.841"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="InParanoid" id="F9X567"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="925"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="826"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1366"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2016" mass="209633" checksum="28663DAFF66392E3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5B0</accession>
    <name>F9X5B0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_39509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854019.1">
        <property type="nucleotide sequence ID" value="XM_003853971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5B0"/>
    <dbReference type="FunCoup" id="F9X5B0">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5B0"/>
    <dbReference type="GeneID" id="13404358"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39509"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_1_1_1"/>
    <dbReference type="InParanoid" id="F9X5B0"/>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="321" mass="36838" checksum="B4F267D656C5F890" modified="2011-10-19" version="1" fragment="single">RHASAAAAVAEKPAEDSHQSSNTPAQATGPKKAFRLVCGTVVSRPPVLTRELTSFEKAFFLYQKRLNERLALPFTRYFYIKKDTPADIEWKRKAAVRKTAARDVGVYNAYSDEGWNDEVLAGSTLSEPEDIVEKLIRDAEGKDIIDAEPVGDEETKVRKPVGEVSIDRPLSRRTRDDEENNTKSLNRRLDRNLYLLVKNKHGHWRFPQDRLYAREGLHQAAERVLLQAGGINMNTWVVGNHPIGYYMNKFAAPILSKILPNRLQEFGEKVFFMKVRIFAGQTDLKLNELGDTEYEWLVKEEIEERVSKKYWMAIRNMLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Z7</accession>
    <name>F9X5Z7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_69270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854644.1">
        <property type="nucleotide sequence ID" value="XM_003854596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Z7"/>
    <dbReference type="FunCoup" id="F9X5Z7">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5Z7"/>
    <dbReference type="GeneID" id="13400917"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69270"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.77"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="InParanoid" id="F9X5Z7"/>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390146" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="432"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="560" mass="61466" checksum="257767D25BAF1DFF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X691</accession>
    <name>F9X691_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_69942</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854385.1">
        <property type="nucleotide sequence ID" value="XM_003854337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X691"/>
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        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X691"/>
    <dbReference type="GeneID" id="13395571"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69942"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.608"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="InParanoid" id="F9X691"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="BRENDA" id="1.6.2.2">
        <property type="organism ID" value="7075"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:4914"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
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    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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        <location>
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        </location>
        <ligand>
            <name>FAD</name>
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        <location>
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        </location>
        <ligand>
            <name>FAD</name>
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        </location>
        <ligand>
            <name>FAD</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004572"/>
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        <source>
            <dbReference type="RuleBase" id="RU361226"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP89361.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="313" mass="34213" checksum="D49A8972564085A7" modified="2011-10-19" version="1">MPEALDYKTFVVPLVIVVVAILGGFFFLTGEESPKDRPQPPAPEKAQQESRGPNTAIDPKTFTEFPISEKTQTSHNTAIYRFKLPTEDSILGLPIGQHISLAADLDVTDPKTGEVQNKEVVRSYTPISSDVTPGHFDLLIKSYPTGNISRHLATLNVGDKMKVRGPKGAMVYTPNMVRRFGMIAGGTGITPMLQVCQAIRRGRKDGDKTEVDLIFANVNEEDILLREDLDALAKEDGFNVYYVLNNPPSGWTGGVGFVTADMIKERLPAPAKDVKILICGPPPMVSAIKKATESLGFDKARPVSKLEDQVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6S6</accession>
    <name>F9X6S6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_25206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853768.1">
        <property type="nucleotide sequence ID" value="XM_003853720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6S6"/>
    <dbReference type="STRING" id="336722.F9X6S6"/>
    <dbReference type="GeneID" id="13404107"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25206"/>
    <dbReference type="eggNOG" id="ENOG502SP5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="F9X6S6"/>
    <dbReference type="OMA" id="RHTKCNE"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="367" mass="41361" checksum="EE7E2DCB9B048880" modified="2011-10-19" version="1" fragment="single">RKPHYKSRKGCLACKKRHVKCNESRPKCSHCARLEIECVWPESPANALPSPHSPGQFQSHSPASSVDQQRPAAGRPPELAVDDMKLLHFWTVNTATSMNYASHLWQIVIVDMAFHHHFLLHGILAVAAIHKATIFPAERETLITQSSSHIGIAIASFRHLLATPVPATCVPVFLMAGLLSIHSLGLAQLRTPTDAVGEIYTWMRLVKGTQSTIQQNWQRLQASEIAPLLSRGRAGLVLTEVEEVNHLKSLVQDEVHLTVSERQTYFDAINQLQTVFGNVLYSKGDEIQASAMVSSWVALVPPEYHELLASREPVALVIIAYFAVLFREQQHVCWWFRKWDVWILESVRAQLPTAYERWLEWPTAQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X8</accession>
    <name>F9X6X8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">H+/Ca2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_70055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854352.1">
        <property type="nucleotide sequence ID" value="XM_003854304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X8"/>
    <dbReference type="FunCoup" id="F9X6X8">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6X8"/>
    <dbReference type="GeneID" id="13404259"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70055"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6X8"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="466"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="853"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="779"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116476" checksum="6CB1CABA5D33313F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7S9</accession>
    <name>F9X7S9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_27543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853812.1">
        <property type="nucleotide sequence ID" value="XM_003853764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7S9"/>
    <dbReference type="STRING" id="336722.F9X7S9"/>
    <dbReference type="GeneID" id="13404151"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27543"/>
    <dbReference type="eggNOG" id="ENOG502SV73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104298_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7S9"/>
    <dbReference type="OMA" id="HAVIHMK"/>
    <dbReference type="OrthoDB" id="3650189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="151" mass="16694" checksum="B88BF67507EF674C" modified="2011-10-19" version="1" fragment="single">TLFPDYRHRNRGFFAVGRVCAVLWAEPAPVSAGIAIDRSLVSSTYHGERIFSKVRRFVIVASYESHSIALPIVSYGRQGASKRGVNPKHHAVIYTGKNEPLPFAMEHGLLRPGIRAVPDNPLDTLDSASRINFSKVYTIEHNVKVKSVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7T2"/>
    <dbReference type="GeneID" id="13395639"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91662"/>
    <dbReference type="HOGENOM" id="CLU_1983332_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7T2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395544" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="126" mass="13636" checksum="3029EC5C95C57709" modified="2011-10-19" version="1">MQLSQLLIIASLFFDASLACGGFNVCGCFDEHNHMMCTEDLPSPLEETDCNDCLSSSAAIQMVTAEMCCYPTTFDARLHGSANGLDRALTAGGKGNQVFLFYVSARFGDGSRQAKTRVHLELLEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X804</accession>
    <name>F9X804_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_38213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853990.1">
        <property type="nucleotide sequence ID" value="XM_003853942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X804"/>
    <dbReference type="STRING" id="336722.F9X804"/>
    <dbReference type="GeneID" id="13395474"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38213"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="InParanoid" id="F9X804"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="435" mass="48974" checksum="49838F2C8BBFEE51" modified="2011-10-19" version="1" fragment="single">LLELNSAIHLQFREAHEGHKPHAGLDPSRASTGVVWTTERAYERGYGDDPTGWANLGQGAPEVDDEIKGCFERPHTIDISMTGREYGPTAGIKPLREAVAHLYNEHHRQGKVSKYTWENVCIVPGGRAGLIRIAAVLGNAYLGFFIPDYTAYNEMLSLFKNFAAIPIPLKKEDGYQIHPEKIEEEISRGTSVILTSNPRNPTGKMVSRHELEEIQDTCRDRATLIMDEFYCGYNYTTDCDGTVISAADNIDDVDEDDVLIIDGLTKRFRLPGWRVAWIVGPKEFIKALGSCGSYLDGGTNVPFQEAAVSMLEPTRVRTEMVALQTHFRMKRDYIVGRLEAMGFTLDYTPDSTFYLWLNLEALPIEINDGLNFFQACLAEKVIVVPGIFFDLNPSRRRDLFDSPCHHYVRVSYGPKMEVLKAGMDGIERILKKYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X830</accession>
    <name>F9X830_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_92219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854145.1">
        <property type="nucleotide sequence ID" value="XM_003854097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X830"/>
    <dbReference type="STRING" id="336722.F9X830"/>
    <dbReference type="GeneID" id="13404485"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92219"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1143"/>
    <dbReference type="eggNOG" id="ENOG502SDY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576477_0_0_1"/>
    <dbReference type="InParanoid" id="F9X830"/>
    <dbReference type="OMA" id="NARETRM"/>
    <dbReference type="OrthoDB" id="10264374at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391437" evidence="4">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="47099" checksum="2D37CDAB89152EAD" modified="2011-10-19" version="1">MKFSNAVRCVLGSVLLANAQVDLGTAASFGALAPAGVTNTGDTVINGDVGTTGTSVTGFPPGVYTGSLYIGDGVAAQAQADSTAAFNQGQALTPTQDFGALAELGGLVVGPGVYSFDSAVDLTGVLTLSGAGTYVFQIGSSLTTASASVVALTNGARACDVYFIVRSAATIGTDSNFAGNILAGTGITLNTGATVAGGLYAGSAVTLDSNTVSSCGGATPPSSSSTTVSATSASTTVSVTASTTSEPSSSTTVSTTASVPTMTTAQTSTTQKSTTEKSTTKATTTTGKSTFTTVTKTTKKTTTTQKNTPPAYPTTTTTKKATTTTKKATTTTKKAETTTTKKATTTTKQATTTTKKAETTTKKAETTTTKKAETTTTKKAETTTTMKAETTTKKATTTTQKATTSTEKATTTTKKPTSTTTTKVTSTTTKGPAPPPPPPTKPAPPPAPAPPTPKPAPPPPAPPAPPAPPAAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8C7</accession>
    <name>F9X8C7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_70899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853495.1">
        <property type="nucleotide sequence ID" value="XM_003853447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8C7"/>
    <dbReference type="STRING" id="336722.F9X8C7"/>
    <dbReference type="GeneID" id="13397240"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70899"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="InParanoid" id="F9X8C7"/>
    <dbReference type="OMA" id="HMVKGTF"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="353" mass="39522" checksum="870CA6F1F75689A3" modified="2011-10-19" version="1">MAAKPPPNSGARYKSTWGGDENLANVTDAERATRNADAAELNDLYYDFITDHYQGGWGDKFHFCGYQPRESWETAQARHDHHLAMVTDIRAGMKVLDLGCGVGGPAREIAAFTGAHITGVSINGMHVERSNLYNAEDGLSDQCHMVQGNFVDLPFADETFDRAYSIEALCCAPDVEKAYSEVWRVLKPGGKLGFLDWVITDKYDGENEKHRKIRSEIEKGGAVPFMTTVGSHVEKLEGAGFRMVMEEDRATAKANPIPWWWALDGKHATTMRDRFMAWRMGEKPFKCIWYLAKVMNAMHLLHPSRMQALETVSMCVYSCRDGGKEGIFSPMHLFVCEKAEVKVKDEVPVVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8M2</accession>
    <name>F9X8M2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853138.1">
        <property type="nucleotide sequence ID" value="XM_003853090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8M2"/>
    <dbReference type="GeneID" id="13399758"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109292"/>
    <dbReference type="HOGENOM" id="CLU_944003_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8M2"/>
    <dbReference type="OrthoDB" id="10505173at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="295" mass="33975" checksum="B7069AE08EEBFFBC" modified="2011-10-19" version="1">MLSHVADLTGRGEEDEELVMVVRWLLGKLDKAVEDAESRNLAWDSSPDNAWYAPSDHPFTNREASHAYDTSQQSIPHTNVTTAEAARAAYISKMWDIMDKKLTEMHLEMSPIPLHFSLQKDPQHRHYITHTFRPTIMDRFNMQNLQLDQITTPTSTKLRNILVLLNDKTIFWALQSRLVALQWTVEGYKDLAHKIMYQVTERLLDEAGMRLYLSDMTGRGEEDGELVGIAHWLFNEAPSDSSLQMKLEWQDSEAYAEPVERECYYEREKDEEGIPPRVLLEPCTGDAGMEAEKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8U7</accession>
    <name>F9X8U7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_41072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852868.1">
        <property type="nucleotide sequence ID" value="XM_003852820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8U7"/>
    <dbReference type="STRING" id="336722.F9X8U7"/>
    <dbReference type="GeneID" id="13397189"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41072"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.156"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8U7"/>
    <dbReference type="OMA" id="FFNAWMS"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="418" mass="45894" checksum="9BDB306B53F263D9" modified="2011-10-19" version="1">MAPINVLMVGTGEYTTGFVGGTSSKSDKKVGVVGLTLFDLRRRGKVGQLSMVGVSGNKFPAIRDHLHKNITQAYNGLDTSFTSFPADDTRDPDAYKAAIDALSPGDAITIFTPDPTHYPIALYAIQRKIHVMITKPAVKLLSEHQHLLSEARAHGVFVYIEHHKRFDPAYADARNRAVRGDLGEFNYFYSYMSQPKSQLETFKAWAGKDSDISYYLNSHHVDVCESMVPSWRPLKVTASASTGVATDLGCVAETEDTITLLVDWVKKDGGEGRRATGVYTASWTAPQNAGVHSNQYFHWMGSKGEVRVNQAKRGYEVTEDESGLTHYNPFYMKYAPDEEGNFAGQSGYGYISFEKFLDAIEALKNGKATLDDLDKRGLPTLKNTIATGAILEAGRRSLDEGGRGVEIVVGADGVWTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X995</accession>
    <name>F9X995_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X995"/>
    <dbReference type="GeneID" id="13399729"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92893"/>
    <dbReference type="eggNOG" id="ENOG502R8X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306133_0_0_1"/>
    <dbReference type="InParanoid" id="F9X995"/>
    <dbReference type="OrthoDB" id="10461023at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="109210" checksum="E5427671010A4705" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9C2</accession>
    <name>F9X9C2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_80332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80332"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390262" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="76" mass="8095" checksum="1971FFFA597D301E" modified="2011-10-19" version="1">MQISQMSIVLLSIASTALAGAATCDRTKGVFGFCHGEVNLPCANNSPCIADSGHNPPLPCNYDVYNRFQALCFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9G2</accession>
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        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502QQWJ">
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    <dbReference type="InParanoid" id="F9X9G2"/>
    <dbReference type="OMA" id="VLKSPKW"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glucose_resp_signaling"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="704"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="920"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="1390"/>
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        <location>
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        <location>
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        <location>
            <begin position="1400"/>
            <end position="1420"/>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="1430" mass="161467" checksum="C77AE95A17DE02FE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA84</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
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                <person name="Schouten H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391222" evidence="6">
        <location>
            <begin position="17"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="152"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="37086" checksum="7E8C079B66C49D93" modified="2011-10-19" version="1">MQTFSLLLAALPAVLALPSIDKRQTANTIPGSWIAQVNNDAVLSKVLGTVKTMTGIKPTLQYDMGSFKGFAFDAPETVVDMLSAIGALKHVEPDTMMSINMPIAEATEEPAYLQDRAMVTQSNAAWGLARISNKKNGTTNYNYDNSAGANVVAYMIDSGINANHTLFEGRATQGPTFVDGEDGNDNNGHGSHTAGTVGSSNYGVAKKATLIGVKVLNVNGTGKTSITVKGIEWAVNDAKAKGITGKCVMSISIGGNANDAANSAVKAATDAGIFVAVSAGNNNVDASQQSPASAPSACTVGATDTTDTKASFSNYGSMVDIWAPGVSIKSLWKGSNTAVMTASGPARRLLTLLDWPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAF4</accession>
    <name>F9XAF4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_72248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852229.1">
        <property type="nucleotide sequence ID" value="XM_003852181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAF4"/>
    <dbReference type="GeneID" id="13396907"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72248"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.461"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_1_1_1"/>
    <dbReference type="InParanoid" id="F9XAF4"/>
    <dbReference type="OMA" id="FQMRTHH"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="120"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="324"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="497" mass="54833" checksum="0070E564412FB792" modified="2011-10-19" version="1">MTRASVFRRRDQAYGDKDGVNGGATSRGNDQEKRSQDGSPAANKQLPLYNQDGHQVNHAGHKVTPGIQPDGESGRKWFNPLHFFRICWTSSCTASRYTNVLWPFTIAAMVLHFGFRDLELWIFITAYIGMVPAANLVGFAGQELARKMPKVAGVMIETTFGSVVEIILFTVLIVKAKHQMEADPNAEPNTAVIRAAILGSILANMLLCLGLCFFVGGIFHPQQVFHEAVSEVGSNLMLVAGMALVIPTIYYNTLLDRTGEPISAESLKIARATAIVLLVAFCVYVWFQARSHHGLYEDILEADEERDHDRHKDLRKPKLTLTEAILALIIALTFVAFMAVFLVEKIEYMIANHNLSDAFLGLILIPIVEKASEHITAVDEAYDNQMNFALSHVLGASIQTALLNTPIVVLIGWGLHVPMSLDFEIFDAIVLILAIIVVGNFLRDEKSDYLEGALCVFVYILIAICAFFYPDPQHGQGTSSAHSEAMTEGAARMLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAK8</accession>
    <name>F9XAK8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_41625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
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                <person name="Dehal P."/>
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                <person name="Oliver R.P."/>
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</entry>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="10682" checksum="EA587890038987CE" modified="2011-10-19" version="1">MAVPDACPNAAQSTANASAMHIPHANGKTQPWLNAYPPAKQDLVGVAESRGQMLLLDGTGGSGTTAMPNQVALPPKTKEQQEKEQKFKDNETQDKPQTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB74</accession>
    <name>F9XB74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_41701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852418.1">
        <property type="nucleotide sequence ID" value="XM_003852370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB74"/>
    <dbReference type="GeneID" id="13394173"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41701"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.829"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="InParanoid" id="F9XB74"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30927" checksum="3465FDFF8A2EFD3E" modified="2011-10-19" version="1">MASGAKKLIPSDPEKVMVIRKVTPDIVTFSTPFQRMGRISIGGRGTLVRLQNGSLAIFSPVALTDSVKETTASLGGPVKYIVAPDQEHHIFLEAWHNAYPQATILAPDTLPDYRSKQSYPSLSTATWHLFKPHPAPTTVSPDFDADFDIEYVSAHQNKELAFLHKPSRTLIQADILFNLPATEQMSKSGVSPTQGLLTKIFAGLMHTRGEATWQRRMIWYGTSAGDRKGFNASIGRIAKWDFDRLIPCHGDVIETGGKGIFDKVMKWHLDALKQQETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB7</accession>
    <name>F9XBB7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 9">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_109408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NMT family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 9"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852702.1">
        <property type="nucleotide sequence ID" value="XM_003852654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB7"/>
    <dbReference type="SMR" id="F9XBB7"/>
    <dbReference type="FunCoup" id="F9XBB7">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBB7"/>
    <dbReference type="GeneID" id="13397024"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109408"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.213"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329609_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBB7"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05284">
        <property type="entry name" value="arabinose_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="871" mass="96144" checksum="7846CA5EE920BC2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB8</accession>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">MYCGRDRAFT_93097</name>
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    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB8"/>
    <dbReference type="GeneID" id="13393892"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93097"/>
    <dbReference type="eggNOG" id="ENOG502RGA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517977_0_0_1"/>
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    <dbReference type="OMA" id="SIRCHAC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87092.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="526" mass="59215" checksum="DC58AFA16AF1F6D7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">ER-derived vesicles protein ERV14</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
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    <dbReference type="GeneID" id="13397017"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109418"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.234"/>
    <dbReference type="eggNOG" id="KOG2729">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
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    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="29"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="EGP87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="147" mass="17157" checksum="6EEEB023760E16EA" modified="2011-10-19" version="1">MSGEAWLFLLAVLLNAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNMYIIPEAGLHAFLTILFLINGYWLPLILNLPLLGWNAKKIFENQHLLDATEIFRKLNVHKKESFVKLGFHLIMFFFYLYSMIVALIRDESGPVKNARLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC86</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852588.1"/>
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    <dbReference type="AlphaFoldDB" id="F9XC86"/>
    <dbReference type="STRING" id="336722.F9XC86"/>
    <dbReference type="GeneID" id="13393964"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104494"/>
    <dbReference type="eggNOG" id="ENOG502SANZ">
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    <dbReference type="InParanoid" id="F9XC86"/>
    <dbReference type="OMA" id="AYGEPME"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="InterPro" id="IPR046591">
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    </dbReference>
    <dbReference type="Pfam" id="PF20354">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="16116" checksum="A041D60504889103" modified="2011-10-19" version="1">MHIDDTRDRVYVRDLDEELADVESDEEKGLIFLPDIEEYFSRIPQQVLNRRRDSEHEGQELVLYSEPKSLTVDEGHDSVRKAILEARQRARDKAVEEARQQDMNARYGQSDHAEVGETAHGYAAGYVVEQDPDPDAMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCE0</accession>
    <name>F9XCE0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_109652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852351.1">
        <property type="nucleotide sequence ID" value="XM_003852303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCE0"/>
    <dbReference type="FunCoup" id="F9XCE0">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="GeneID" id="13396785"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109652"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.730"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="F9XCE0"/>
    <dbReference type="OMA" id="NWACVAL"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="389"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="788"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="99102" checksum="AC81F7A308625BE5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD46</accession>
    <name>F9XD46_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_59874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851878.1">
        <property type="nucleotide sequence ID" value="XM_003851830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD46"/>
    <dbReference type="STRING" id="336722.F9XD46"/>
    <dbReference type="GeneID" id="13401427"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_59874"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.259"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="InParanoid" id="F9XD46"/>
    <dbReference type="OMA" id="WVFEHED"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26374" checksum="3DC7568600DC299C" modified="2011-10-19" version="1">MSKAIAIIAGVGPGTGAEIAKRFAASYPVVLLARNPSNFEPTAEEINKSGGRAIGISTDVSSQDSLKAAFSKIEQEFSGAPIAAAIFNASSRPKRKPILEISVEDFETAHGVVAKGAFMFAQHVLPGLLLHASDSSAKYPPTLIFTGATASIKANAQMSVFASAKFAMRALSMSIAREYAPQGVHVAHSIVDGVIDIELTKEWTKGMAPEAKIAADDIAESYWYLHTQSKRCFTNEIDIRPMMEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE41</accession>
    <name>F9XE41_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_44018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
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                <person name="Schouten H.J."/>
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    <sequence length="579" mass="63049" checksum="C2DA274DA3785191" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Conde-Ferraez L."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851080.1">
        <property type="nucleotide sequence ID" value="XM_003851032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG73"/>
    <dbReference type="FunCoup" id="F9XG73">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG73"/>
    <dbReference type="GeneID" id="13397500"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74168"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="InParanoid" id="F9XG73"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="278" mass="30349" checksum="C6548256893D0EE1" modified="2011-10-19" version="1">MNHLPQSWGRASHTPRDDVYGTYNSSYLPQSHGGTQQPITHTQSPIVTGTSVIALKFSSGVVIAADNLASYGSLARFTDVHRLKPFNRKSVVGFGGDVSDMQYLDRLLNSLDVEENYSVGAAAADSEDGDALMSAKNLHTYLAKVMYKRRTDFNPLWNALLVAGLDEKNKPFLASADLLGTTFSAPTLATGFGAHLAQPILRRAVPDEAAASKLSREDAVAAVKACMKVLFYRDARSMNEYSIAVIDEKGVELHENEKLENQSWDFADKIRGYGTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGU5</accession>
    <name>F9XGU5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ERG3, C-5 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ERG3</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_74506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849939.1">
        <property type="nucleotide sequence ID" value="XM_003849891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGU5"/>
    <dbReference type="FunCoup" id="F9XGU5">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGU5"/>
    <dbReference type="GeneID" id="13395051"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74506"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.169"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_3_0_1"/>
    <dbReference type="InParanoid" id="F9XGU5"/>
    <dbReference type="OMA" id="GPGLWYN"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000248">
        <property type="term" value="F:C-5 sterol desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="375" mass="44288" checksum="4EF9956F0E6F0116" modified="2011-10-19" version="1">MDVVLEVFDTYLFDRVYATLLPISQSITFDPVSTLAASLKTFANHNATFAQHQQQQQQEYLTKSSWQYTPTTDSFSLEPSEYAYLSRWDRDNLFRQFVSFFIISSVFANVLYFTFATLSYIFIFDKTTVNHPKYLKNQMKLEIQQAIAAIPTIAVFTAPWFVAEVRGYSFIYDNLSEVNHPIVTHIFGSWYTYLQFPIFLMFTDFCIYWIHRALHHPILYRRLHKPHHKWIMPTPYASLAFHPLDGYAQSVPYHLFPFLFPLHKFAYIALFTFIQIWTVMIHDGEYVANSPIINGAACHTMHHLYFNYNYGQFTTLWDRLGGSYRKPNEELFKRETKTSDAEWKRQAKEMEKMVVEVEGKDDRSYEPDVVVKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH07</accession>
    <name>F9XH07_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850250.1">
        <property type="nucleotide sequence ID" value="XM_003850202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH07"/>
    <dbReference type="GeneID" id="13394678"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110595"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.651"/>
    <dbReference type="HOGENOM" id="CLU_906765_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH07"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="307" mass="34540" checksum="4154BED2D0214638" modified="2011-10-19" version="1">MFVAPTLAFVTDKRNHHPPLFTFGFSLTPSCVSAPPAHTQQSLRTICASEAPHQIHRYRCNEASHHPADSMAECHFFRLPVELRFAIYGFAYGTGRTIVPRKLKTIPRNTTAVKQAIEHKVGHNQEMITLEQADSSQEKPKNVNEVRLVSKRFHAEAMQCLTENNTFRLARHLGSLVLVSPQFAQDIGSLFLDWNNHHARDRLDLNRLCPRLQSLEIFVELDLLDDSKFSRSPALPTDEDLRSSSMVDALSMVRGLKHFKLHESSAGHPPYCNILFAGWALGNAARVLEGLEKVLLAMVMREKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHC9</accession>
    <name>F9XHC9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_105616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850214.1">
        <property type="nucleotide sequence ID" value="XM_003850166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHC9"/>
    <dbReference type="FunCoup" id="F9XHC9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHC9"/>
    <dbReference type="GeneID" id="13394567"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105616"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.724"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="InParanoid" id="F9XHC9"/>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="219" mass="23679" checksum="AF1E831B59DACAB2" modified="2011-10-19" version="1">MRVSTPPPLEFEQIDDLLYLTRANESQELDTSIQQLAEQYQCRRKDILEAAIDPETGNTVLHFCSANGLSELLSSILSQLKIEEGADQTGFSPLINHGNKEGNTPLHWAAYNGHLPVVKTLLGVGADMWLKNAAGHLAMFEAERADKNDVVQHLLEAGGKEVEKAGVEGQASAEDVEDVAEEEGAEGGFTLRAGTAGQDDDVKMEDVNMEDGKTESTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHM2</accession>
    <name>F9XHM2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HAG2401</name>
        <name evidence="19" type="ORF">MYCGRDRAFT_61567</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850394.1">
        <property type="nucleotide sequence ID" value="XM_003850346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHM2"/>
    <dbReference type="FunCoup" id="F9XHM2">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHM2"/>
    <dbReference type="GeneID" id="13394229"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_61567"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="F9XHM2"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="388"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="550" mass="62540" checksum="BA147800E602898A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHS8</accession>
    <name>F9XHS8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850548.1">
        <property type="nucleotide sequence ID" value="XM_003850500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHS8"/>
    <dbReference type="GeneID" id="13395201"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105321"/>
    <dbReference type="HOGENOM" id="CLU_2777841_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHS8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="69" mass="7406" checksum="DA8BCA29A35D6C2C" modified="2011-10-19" version="1">MMSSLPLLDASPTRPGGCPTFRGYQRLDVHQSAISPLAEFEPAVALPTDHARKAVKVQSGIRLVMFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHZ1</accession>
    <name>F9XHZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_46008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850353.1">
        <property type="nucleotide sequence ID" value="XM_003850305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHZ1"/>
    <dbReference type="GeneID" id="13394856"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46008"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003487_2_1_1"/>
    <dbReference type="InParanoid" id="F9XHZ1"/>
    <dbReference type="OMA" id="AMCTEAF"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="182"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="651" mass="72792" checksum="F42BF255D90D7BED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI33</accession>
    <name>F9XI33_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pet127-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_21181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849892.1">
        <property type="nucleotide sequence ID" value="XM_003849844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI33"/>
    <dbReference type="STRING" id="336722.F9XI33"/>
    <dbReference type="GeneID" id="13395173"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21181"/>
    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003477_0_2_1"/>
    <dbReference type="InParanoid" id="F9XI33"/>
    <dbReference type="OMA" id="ETRINEH"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67782" checksum="2D85836EED71B213" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI36</accession>
    <name>F9XI36_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_87018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849894.1">
        <property type="nucleotide sequence ID" value="XM_003849846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI36"/>
    <dbReference type="FunCoup" id="F9XI36">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XI36"/>
    <dbReference type="GeneID" id="13395172"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87018"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.67"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="InParanoid" id="F9XI36"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="32197" checksum="B0F357AED9A24E9B" modified="2011-10-19" version="1">MGDSATTNGNGHAAADNSFAVKAGLAQMLKGGVIMDVVNAEQARIAEEAGAVAVMALERVPADIRKDGGVARMSDPSMIQEIMAAVTIPVMAKARIGHFVECQILQAIGVDYIDESEVLTPADPTHHVDKSVFTAPFVCGCRNLGEALRRIAEGAAMIRTKGEAGTGDVVEAVRHMQTVNQEIAKASTASDADLRMMARELECDLGLLRQTAQLKRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFKSGDAAKRAKAIVQATTHYNDPKVLMEVSIGLGEAMVGINCGDMREQEKLAKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIN4</accession>
    <name>F9XIN4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_75050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850280.1">
        <property type="nucleotide sequence ID" value="XM_003850232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIN4"/>
    <dbReference type="SMR" id="F9XIN4"/>
    <dbReference type="FunCoup" id="F9XIN4">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIN4"/>
    <dbReference type="GeneID" id="13394399"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75050"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.576"/>
    <dbReference type="eggNOG" id="KOG0456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="InParanoid" id="F9XIN4"/>
    <dbReference type="OMA" id="DNINIMM"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="485"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="548" mass="59689" checksum="249675A53D85E96E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIP0</accession>
    <name>F9XIP0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_46900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850125.1">
        <property type="nucleotide sequence ID" value="XM_003850077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIP0"/>
    <dbReference type="FunCoup" id="F9XIP0">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIP0"/>
    <dbReference type="GeneID" id="13394704"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46900"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.584"/>
    <dbReference type="eggNOG" id="ENOG502S416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142363_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIP0"/>
    <dbReference type="OMA" id="DNYLCPD"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390650" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="117" mass="13122" checksum="301391484F5E7E02" modified="2011-10-19" version="1">MQSFNLLLLPILLLIAPGMAQFFNFGNMFQNQQQAEPQNMASDSQWYMQNYESARCDKYLCPHTLSCVHFPHHCPCAFPNVEDKVEFGDGSMACVSKGGFKAGESARKVELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIV9</accession>
    <name>F9XIV9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_47390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849422.1">
        <property type="nucleotide sequence ID" value="XM_003849374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIV9"/>
    <dbReference type="FunCoup" id="F9XIV9">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIV9"/>
    <dbReference type="GeneID" id="13402217"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47390"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.364"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="InParanoid" id="F9XIV9"/>
    <dbReference type="OMA" id="FRICGMK"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="329" mass="36341" checksum="0688739DEF3F8F06" modified="2011-10-19" version="1">MADLKSFDQTKLKAFENAAAGHDGVLLDESGELVIKPCTAEEVDFYQESISQHPKFYELMPTFMGTLTLGAPAQVLDTTAAQEELTQEQKDQTLLHGKALTTETAIVLENLEHGFKQPNVLDLKLGSRLWAEGTKPEKADRLDKVSAETTSGSLNFRIAGMKVWNGQGFDIYDKFYGRKFSKDNVKDGFAAFFSSLSAGVPKDDARLLLETILADITKARHSLERSESRMYGASILVVYEGDNEALDTIMRGPPKAPGGDERAPTTLEVKQSQEEDEEEDEDAPPVAHRVKMIDFAHAQWTPGEGPDENVIKGLKNIEDQMDALIALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ30</accession>
    <name>F9XJ30_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_30651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849302.1">
        <property type="nucleotide sequence ID" value="XM_003849254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ30"/>
    <dbReference type="STRING" id="336722.F9XJ30"/>
    <dbReference type="GeneID" id="13398923"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30651"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="InParanoid" id="F9XJ30"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="25752" checksum="1596F502539292E8" modified="2011-10-19" version="1" fragment="single">MPIRKRNEFLDGGDSEEELENGSDSDAEEGRAAIGGHANKRRRVDTESERSLSEVEDEVKEEKGEDTRFDFSNFEDAEPPADDQDEDIAQDDNADTPPTLPLKPAKKSSDLKQYEAAQRALRKSGVIYISRVPPFMKPHTLKHLLSPHAPSGLNRIFLTPEDQIQHTKRVKNGGNKKKSFTDGWVEFTSKREAQRAAELLNGNIIGGKKGGFYHDDLWNVKYLKGFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJD3</accession>
    <name>F9XJD3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Torriani S.F.F."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390684" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="124" mass="12944" checksum="0E724E655EBE5706" modified="2011-10-19" version="1">MKNIIFLASTLLFALGTIAAPAAEAEALGRIPVPPYCYEECTSGWLTAIPLSAVRGTAGFGDPVFGFESREGTGMVDRWRVRLDGGPSGGFGERAGGGAGRGWVEGAVNEGSLIDFLFWASSEV</sequence>
</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9XJI0"/>
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    <dbReference type="OrthoDB" id="3858011at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="28798" checksum="9AC64AEFEAB40CAC" modified="2011-10-19" version="1">MSAAKKAQQAKMAQALAIAALVQAPASPMKTKLDHEERGKRSTAYRIGPSRVSKNSSPKGKGKLKKGTLQKSPMQKSPPKQKRSTGKSKGSNVNNPCDFLALHPDVRKIIYKYVLAGSTHADLEPAGIQRPSHLSNGYTIPAILKVCSSVRLEAAQVWYPQMTFLYCHEKTLLDWLRLIGPANRAIVRTLRPDRILQSQRWAEAAVVFTHARIKDAGFEEIVEDAIEAAFWKKSPEVVGGSCEGKWAFIRGEKWAVDGAVAA</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="eggNOG" id="KOG2734">
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    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
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    <dbReference type="OMA" id="TDWREQE"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
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    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="586" mass="64691" checksum="78902E95C5EBE383" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKC1</accession>
    <name>F9XKC1_ZYMTI</name>
    <protein>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849526.1">
        <property type="nucleotide sequence ID" value="XM_003849478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKC1"/>
    <dbReference type="STRING" id="336722.F9XKC1"/>
    <dbReference type="GeneID" id="13402388"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47312"/>
    <dbReference type="HOGENOM" id="CLU_2032275_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKC1"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13557" checksum="20456C73C79429F5" modified="2011-10-19" version="1" fragment="single">AVRRAALGIDSRQDDTTIELHSKLGCDRSTRQAFTGRQLMRTLEGGYSMPIGAQTEEAVTAELIVRAIVVSVYGRNGAEIRTRIRARKAEVVENVGLRWEDLREDIGRTAVQFAPDPCDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLF1</accession>
    <name>F9XLF1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_87823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849098.1">
        <property type="nucleotide sequence ID" value="XM_003849050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLF1"/>
    <dbReference type="STRING" id="336722.F9XLF1"/>
    <dbReference type="GeneID" id="13398495"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87823"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.344"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045732_3_1_1"/>
    <dbReference type="InParanoid" id="F9XLF1"/>
    <dbReference type="OMA" id="HFLQIAY"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="407" mass="45327" checksum="3C5336D6C0988F36" modified="2011-10-19" version="1">MAADGDLKEHALNSSHDFYDLLGVPSTANDSEIRRAYRKTALKYHPDKVGASDSAALEKFHLLQIAYDVLLESDVRQLYDNARRAREEKKEREQAYEGRRRQMKDDLERRENAGVAGLKRKREEANEEEAFQRELKRLAADGARRRREREEQLRKEALEEFERENSELNGVGPDADQQSTPAKARQTGTEDIDRTVTLRYPADTKGASSEQLSKEELISRFSRFGKIEDAVLRDKKLKGEGEKHRREYTTAIIVFKSIVGAHAAVTDVPILASSAEGANWRVFENVTWASGREPDCIPKIKSAGTPKTNGSAPREVFTGAAPTTPILNKIKDADVGGGGLRKVPSFGSFKGTPKASAQTSTPCGVGSPSMEELTMIRLKNAERRRLAEKLRKEEAEAEAAEAEEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLF2</accession>
    <name>F9XLF2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_49141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848904.1">
        <property type="nucleotide sequence ID" value="XM_003848856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLF2"/>
    <dbReference type="SMR" id="F9XLF2"/>
    <dbReference type="STRING" id="336722.F9XLF2"/>
    <dbReference type="GeneID" id="13398494"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49141"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008108_3_0_1"/>
    <dbReference type="InParanoid" id="F9XLF2"/>
    <dbReference type="OMA" id="PIRLCFQ"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="29202" checksum="1BF13F19AAF8D132" modified="2011-10-19" version="1" fragment="single">MTLVDWLDDLTVRFLLNLPPAELSSVPRLCFQVEEAQWFYEDFIRPANPSLPSLNLRQFCLTLFQHCPLLSGFNAAQHLAAYEEFLAYKVRVPVRGAILMDDKMEKVLLVRGWKKGASWSFPRGKINKNEPDIDCAIREVYEETGYDAAAAGLVEKNLQSDGEVKSIDVTMREQHMKLFVFRGVPLETYFEPRTRKEIGKISWYNIKDLPGFKKQKGLAGQGTGEAQAAKFYMVAPFLGHLKRFINQQRKPSGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLH2</accession>
    <name>F9XLH2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_111085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849089.1">
        <property type="nucleotide sequence ID" value="XM_003849041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLH2"/>
    <dbReference type="STRING" id="336722.F9XLH2"/>
    <dbReference type="GeneID" id="13398161"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111085"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_2_1_1"/>
    <dbReference type="InParanoid" id="F9XLH2"/>
    <dbReference type="OMA" id="SIKWTGG"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="546" mass="61031" checksum="FC84B59D24BF2EC5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLI8</accession>
    <name>F9XLI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_76469</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="12">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
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    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="13">
        <location>
            <begin position="483"/>
            <end position="557"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="648" mass="73191" checksum="6682B79DA8C97401" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLV1</accession>
    <name>F9XLV1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_96355</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
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    </dbReference>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="34655" checksum="B5952C1AAA809A50" modified="2011-10-19" version="1">MAFTGQPSNAKQGSSTYPCPQSTTSGAQLRAPNPALWGCDDYADVTIKCIDRDIKCHKIILSTNSEYFRKSLQFGLKLKVPENNNIIELTDDDPDAVETVLKYIYTCAYDHDHPRKQDTSYHVGVIMVAGKYLLPTLQAEASIALVSLLPNVQDEASIMYVVDAATNGPEGDELAENLATALESDMLEGFVSSTWFRLLTDEIGPLRRKTFDLFRFALSMKRTRKVVRCPCGRYSVIVRPEVRLAKHIPADFDCCRACGAKIGNDRGTMKLDFVSAHKYLLVADKYEPDRCGSEGPGANRLRRPGIHAGHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMT8</accession>
    <name>F9XMT8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_87981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848323.1">
        <property type="nucleotide sequence ID" value="XM_003848275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMT8"/>
    <dbReference type="FunCoup" id="F9XMT8">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMT8"/>
    <dbReference type="GeneID" id="13396538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87981"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021989_1_0_1"/>
    <dbReference type="InParanoid" id="F9XMT8"/>
    <dbReference type="OMA" id="EPRNENI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="247"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="458" mass="49583" checksum="C56308CBC61F8DFA" modified="2011-10-19" version="1">MNNGNFLRQTHAEAPPQEEDNPLLFEESRKKAGVSTEENRDMISSQHHQVKKSWENPGVYAWGSNTGRVAAPGSTDNVVKTPRRIPFFDGKLLRDIKLDRNFAAAIDENGDLLQWGVAYAPDTKEPVSTLKGKNLTSLVLSKDRILALGNNGTVYSIPVSADEQQSGTKPSEASWVPFWSGSRRVFSTASASDSFPSRGQLGVPGLTWNTRPAGSFDQPHEISTLRGFPVKKIACGDYHSLALDAEGRVFTWGDNASGQLGFDYNADSSIVDAPSLLATGPDTFAFGSGITGSLANNRWTHVQSTPTRIPALSGLFEYDEVNNTSVPIRLAHLSVGSTHAAAVMANITKVDVQSTGSGGHTDDDTNWGADVVFWGGNEHYQLGTGRRNNLNNPTYLQPLDREAEVVRAKKSSGAKEEHRFHVTPRSTVRLGEGGKGRKVSVEQRVECGRGVTSVYSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN43</accession>
    <name>F9XN43_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_76870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848602.1">
        <property type="nucleotide sequence ID" value="XM_003848554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN43"/>
    <dbReference type="FunCoup" id="F9XN43">
        <property type="interactions" value="1101"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN43"/>
    <dbReference type="GeneID" id="13396275"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76870"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.274"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="InParanoid" id="F9XN43"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="498" mass="55013" checksum="3CF1E8F6E711EBC3" modified="2011-10-19" version="1">MPAMLDDPTAPVKYRVSGNPPFPTPDGPLPHDIAPRQVTLRDRVTTATLVPFSSPQEVPPQLTAYLCETLNREIEGGDTYPMTEPLLQSSFGAYWFQNFGAVMVLGEVQAVEEIAQMEEQGVDWTKQCLGSFYVKPNYPGRSSHVCNGGFLVTDAARNRGVGRLMGEGYLEWAPKLGYTYSVFNLVYETNVASLRIWDALGFKRIGRVKDCGNLKSYPDQYIDAIIFGRELGGEGDEYISEERFDKIRFYLKNGTYPNGSDRAEKSRLRSAATHYRLIPNTTGDGEEDKLMLKGKEVVSDPHKQYEIARNMHAASHGGINKTTASIADKYHWVRIKETVSAAIRNCTECKDSAPKNDTAAFTSNKRRAASTNAAPPSTRQRLTVTAGSDDVVAGASPHDNQQMQMQQQQGQQMLPTHHGPAPTAPMAPMQYADNVGAYSDMPVDPQIMQMWSTGPQDGMGLDGSKEAEEADADARLRETLEAQIMTHDYGNQNGHMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNC6</accession>
    <name>F9XNC6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_49723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848413.1">
        <property type="nucleotide sequence ID" value="XM_003848365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNC6"/>
    <dbReference type="STRING" id="336722.F9XNC6"/>
    <dbReference type="GeneID" id="13396251"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49723"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="InParanoid" id="F9XNC6"/>
    <dbReference type="OMA" id="GTHEYCD"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="37"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="428" mass="46923" checksum="FD905C17CA5AA008" modified="2011-10-19" version="1">MSKPNTSHLDNALSTALAKRKQQSTIRQLTTNPATSIDFSSNDFLSLATSQELRAAFLKELQSDPALANHLGSGGSRLLDGNSTYAERLENDIAEFHGAEAGLLCNSGYDANAGLFSCLPQPGDVVVYDEFIHASVHDGMRMSRARKLVHFTHNEPAALRRVLEDCVAEDEALREGRRNVFISVEAVYSMDGDVAPLRDFVAVVKAVLPKGNGHLIVDEAHSNGIFGPRGRGLVSGLGLEKEVTVRLHTFGKALACNGGILLCSPLIRQYLINYARPMIYTTFMSYPALAAIRASYSFLMEGKTVALARNLQMLIRALHERLLEMQESLNLATNMQHLLQCPQQCPDTPIFSILSFEPKILAAHCQRSGFVVRGILPPTVPEGTERIRVCLHAGNSVEQIDALVATIRKWVAKRVHELESGKDVTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNP1</accession>
    <name>F9XNP1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_88256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847930.1">
        <property type="nucleotide sequence ID" value="XM_003847882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNP1"/>
    <dbReference type="STRING" id="336722.F9XNP1"/>
    <dbReference type="GeneID" id="13401659"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88256"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129439_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNP1"/>
    <dbReference type="OMA" id="PDSFVTY"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12862" checksum="ACA3354BD312960A" modified="2011-10-19" version="1">MIRFLGKRSLPQKVDHAPHPHPASPTPSLPQSFASYRERAIQHGPLKGSQTSSATSSAAAAPGSSVLSPYGAIGGKSARELGPIKIGKGEFATRAELPRRFQATPWTEAEIEAVESGGASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNR6</accession>
    <name>F9XNR6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848144.1">
        <property type="nucleotide sequence ID" value="XM_003848096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNR6"/>
    <dbReference type="GeneID" id="13401926"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97053"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.218"/>
    <dbReference type="eggNOG" id="ENOG502RN1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNR6"/>
    <dbReference type="OMA" id="CSTFFAA"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46172" checksum="FFDE18E7D0F6EAA7" modified="2011-10-19" version="1">MSRPSKSREELEDNYDEPLLDSGRSSHDDDGDIELSRLELSGGDRTPLSHYRNRDEEPPPPKRVSMLWIALALAVCVLGFTINTEATAYFEDELGWKKPFATLYITHSSLILPWIVHLAYLRWQSRDVPYTVWVRDYNNSLRSSISTIDAFATSAPRLVLKLPGHTAGPLDFLASSMAIVTLVLTASGMSWFLSLSLTTPADLTAIYNCATFFAAAFSVPLLKEKLGWISILAVALSIIGTFTIAYGDTTADHSDGSDDAIGGSRLLGNVIACGGAVAFGLYEVLFKKWACSSRPESQESSLPLTLAASALTGAYTFAVLWVGLVGLHVLGWETFSVPSAYACLWIAIAVLAGSISITLLVVLVIWTDPVFGSMANVLSVFFVALADWVVWGLSPSFATYTGGALIFVAFGLLSYDSLVVKKRVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNT5</accession>
    <name>F9XNT5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848137.1">
        <property type="nucleotide sequence ID" value="XM_003848089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNT5"/>
    <dbReference type="GeneID" id="13401639"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97071"/>
    <dbReference type="eggNOG" id="ENOG502RHG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2039908_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNT5"/>
    <dbReference type="OrthoDB" id="3644902at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13710" checksum="5A758D603DFD7514" modified="2011-10-19" version="1">MSLLTSNDTTKAKSASYKLMPQQQHVDPTALTASIKIRRNIKLGIFGDNELDWKSIPTWHENGRPWWILNRMPHLRCESDPAYFATILESFRLQKPAMASSTSSNSDTIIIDGEEMVDMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNX5</accession>
    <name>F9XNX5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_50788</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848116.1">
        <property type="nucleotide sequence ID" value="XM_003848068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNX5"/>
    <dbReference type="FunCoup" id="F9XNX5">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNX5"/>
    <dbReference type="GeneID" id="13401943"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50788"/>
    <dbReference type="eggNOG" id="KOG2642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017053_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNX5"/>
    <dbReference type="OMA" id="VWDSKIT"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395704" description="Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP83092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="567" mass="64594" checksum="665907CFF75D87FC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNX9</accession>
    <name>F9XNX9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_50651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848114.1">
        <property type="nucleotide sequence ID" value="XM_003848066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNX9"/>
    <dbReference type="GeneID" id="13401967"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50651"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.285"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9XNX9"/>
    <dbReference type="OMA" id="GFTTMMQ"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="56685" checksum="8F4F8FF83C5E93A2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPA0</accession>
    <name>F9XPA0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_82925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390978" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
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            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6026" checksum="EE45159B938D7C1F" modified="2011-10-19" version="1">MKLTILIAAFIGLIAPISACIEDHCNSYCQSSKQGVGGYCQTDGHCGCRFVDDGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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    <name>F9XPI1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPI1"/>
    <dbReference type="GeneID" id="13401807"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30085"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030126_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPI1"/>
    <dbReference type="OMA" id="RHNIAHD"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44724" checksum="1FE79B705612D72E" modified="2011-10-19" version="1" fragment="single">YNWCNMPHVNSQTYVRPSQEYKLEYVEVIHRHHKRTPYASNTFPEEGCAWNCSDEGLFFGGKPLNPYGNNSAATYWSVYTTDSNPYPPVGFNGTCQFPQITRGGLDDSHQHGVDLKAVYGDMLGFLPSDYDPTSISYRVTNNVITPQVASMLIAGMYPSQKNCDTPLLIQPDSVDSLEPNYPCTAATALFSSYGPGSTSPAWTQHLNASAGLFARLDSLSGVNPNSTGWHKSWDHYFDNLSARLCHDKSLPCNIVNTTNCVSMAEAEQVFRLGEYEYSFIYRDSPQSLPASVGSYGIFVAELAQNLRHAMGEGAPPTGDCKVKYRHNVAHDGSISRLLSILQLERMVWPGMGAEVVFELYSKAGVYFLRVLWGGRVLRSSHPAFGQMDMVPVAQFLAYIDGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPJ4</accession>
    <name>F9XPJ4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF431 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_50298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848211.1">
        <property type="nucleotide sequence ID" value="XM_003848163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPJ4"/>
    <dbReference type="FunCoup" id="F9XPJ4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPJ4"/>
    <dbReference type="GeneID" id="13401513"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50298"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.76"/>
    <dbReference type="InParanoid" id="F9XPJ4"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24449" checksum="EF67129FF72922C2" modified="2011-10-19" version="1">MASTNPHQRKHTFIVEHLDPELEDWQSLEYNTISAESLASNSHFLLSGLTPSFDSASQLNLPSSSKTSQTVESLYPTPEDRQKVCLLDPKAEQDLSPEDGEKFDAFLFGGILGDDPPRDRTGDLRKLGFPGRRLGPEQMTTDTAVRTTRIVVQEGLKLSEIKYVDRPDVDILDENGKPLPNESISMPFKYVADKDGKPIMPEGMYELLASDADKGILDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPV4</accession>
    <name>F9XPV4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_97328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847790.1">
        <property type="nucleotide sequence ID" value="XM_003847742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPV4"/>
    <dbReference type="STRING" id="336722.F9XPV4"/>
    <dbReference type="GeneID" id="13400784"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97328"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.117"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="F9XPV4"/>
    <dbReference type="OMA" id="HPIMREN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="134"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="358"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP82766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="544" mass="60083" checksum="068CD0493A150B62" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ82</accession>
    <name>F9XQ82_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_111677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Schouten H.J."/>
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                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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                <person name="Martins N."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502SQ8B">
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    <dbReference type="Proteomes" id="UP000008062">
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
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        <property type="project" value="InterPro"/>
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            <end position="173"/>
        </location>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2401370_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQY6"/>
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            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
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            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="93" mass="9600" checksum="5DEEF937F49C6B83" modified="2011-10-19" version="1">MASIPLPMSAARPATSRHSSTSRQTSTEITAGGTSTPAKGLANSSGLNEQDVPTYPVFRSPKSLEEDLHSSPSASRVSTRLVTASRSADGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="398"/>
        </location>
    </feature>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="658" mass="73452" checksum="161A967D88826B98" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRS6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106667"/>
    <dbReference type="HOGENOM" id="CLU_2764981_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRS6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="70" mass="7821" checksum="4C0A620C6668E925" modified="2011-10-19" version="1" fragment="single">KSRCFRSDVLGNRFASSTFPISSTDPLCPPSPSTFRTRDPVTKQADGDVAAYSHRVTKQREGRAHSRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRT4</accession>
    <name>F9XRT4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846994.1">
        <property type="nucleotide sequence ID" value="XM_003846946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRT4"/>
    <dbReference type="GeneID" id="13399223"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97928"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.15"/>
    <dbReference type="HOGENOM" id="CLU_726059_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRT4"/>
    <dbReference type="OrthoDB" id="3644851at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="381" mass="42434" checksum="4B0F356AA186590D" modified="2011-10-19" version="1">MPARPSLKLRWSSSQGSGRNRMKPKSVTIERPTPDSRRNAKVLSKKLMALGTIGLVNRPASRACKQAELEKEQKAAVRAAQRAERKANADNEAAELREKLVKERRRGMLKLRGRCRRLRTNDTEGAAPDRYQTSVHVRKTYKDVPLTSNCDTDDDDNIDPQPHAHHAACIDGALHDYTRHPSRRLQVFRSTFASSSGTAYPLRRETHLLKTVLALQIMPPTEQIIFEAKQRPMPHSKPKRPSTVVNDKGYVATRGLIVPGRSSSKSSLESIAGSSITTSISPSELSGRWRADDEFAMAVWEEEEERRRRNDREDPGSKSSRARDVPGADADADKSPGAPTPETGIIASLRSIDFSLTINVWRGLNKFESTSLVSLAVRDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS76</accession>
    <name>F9XS76_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846941.1">
        <property type="nucleotide sequence ID" value="XM_003846893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS76"/>
    <dbReference type="GeneID" id="13396729"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98065"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_20.83"/>
    <dbReference type="eggNOG" id="ENOG502RB4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704394_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS76"/>
    <dbReference type="OrthoDB" id="10294647at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="39874" checksum="499FBC18EB134C6A" modified="2011-10-19" version="1">MSFDGKIVVPLSWCDSSLDPYYRKMGFAIINDPALPEDTEIPEPQLLPSKLYFPILANLNLGFFAGQATAKDGCPSVISWKKSPIPDQIRTWAKKYGVAKECPPLPSQLRELMVELNIPISFGRAIAHECLRRVMRFVDTHISIPKYKSVGETRPSSNKTIHLTIASLAREGVFNNNVEDVGLFKFPQIQSAKIINTPTMEKKKSSPSATQNYRSSYVDEENEEESVKRVDVQNVHTDAIYTKPVTKKNSIPATSTDTDTDTDTGNGVSRAEMNSSIQSILDKYNEKVAQLLECSAMHQKYLHQSAIAINGHDDKLKDHEDKINEHEDRLDAVEKGGIECIKMTAQLHQTVKELKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>P9WEM2</accession>
    <name>LYSMX_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName>Secreted LysM effector Mgx1LysM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Mgx1LysM</name>
        <name evidence="6" type="synonym">MgxLysM</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Plant Physiol." volume="156" first="756" last="769">
            <title>Analysis of two in planta expressed LysM effector homologs from the fungus Mycosphaerella graminicola reveals novel functional properties and varying contributions to virulence on wheat.</title>
            <authorList>
                <person name="Marshall R."/>
                <person name="Kombrink A."/>
                <person name="Motteram J."/>
                <person name="Loza-Reyes E."/>
                <person name="Lucas J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Thomma B.P."/>
                <person name="Rudd J.J."/>
            </authorList>
            <dbReference type="PubMed" id="21467214"/>
            <dbReference type="DOI" id="10.1104/pp.111.176347"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Mol. Plant Pathol." volume="22" first="683" last="693">
            <title>Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity.</title>
            <authorList>
                <person name="Tian H."/>
                <person name="MacKenzie C.I."/>
                <person name="Rodriguez-Moreno L."/>
                <person name="van den Berg G.C.M."/>
                <person name="Chen H."/>
                <person name="Rudd J.J."/>
                <person name="Mesters J.R."/>
                <person name="Thomma B.P.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="33797163"/>
            <dbReference type="DOI" id="10.1111/mpp.13055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CHITIN-BINDING</scope>
        <scope>SUBUNIT</scope>
        <scope>DOMAIN</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Secreted effector that enables the plant pathogenic fungus to manipulate host defenses for successful infection (PubMed:21467214, PubMed:33797163). Binds chitin and suppresses the chitin-induced reactive oxygen species (ROS) burst (PubMed:33797163). Chitin-induced polymerization of homodimers forms a contiguous Mg1LysM highly oligomeric super-complexe that is anchored to the chitin in the fungal cell wall to prevent hydrolysis by host chitinases (PubMed:33797163).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 5">Forms homodimers in a chitin-independent manner through interactions at the N-termini of Mgx1LysM monomers (PubMed:33797163). Homodimers are further polymerized in a chitin-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is up-regulated during wheat colonization.</text>
    </comment>
    <comment type="domain">
        <text evidence="4 5">The LysM (lysin motif) domains are small globular domains involved in binding chitin in eukaryotes. Mgx1LysM contains one LysM domain.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Produces no to only a few pycnidia.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In plants, chitin acts as a microbe-associated molecular pattern (MAMP) that is recognized by lysin motif (LysM)-containing plant cell surface-localized pattern recognition receptors (PRRs) that activate a plethora of downstream immune responses.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="P9WEM2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000460742" description="Secreted LysM effector Mgx1LysM" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>chitin</name>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>chitin</name>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>chitin</name>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>chitin</name>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
        </ligand>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="F9XHX3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21467214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="33797163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="21467214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="33797163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="103" mass="11337" checksum="484BE97DDA9ABB1E" modified="2024-10-02" version="1" precursor="true">MKVTTIIAALLSVAVVDAQNNAQCRKLGLPCHATKTIPYVVKKGDTLTHIAHDIYKRKVGICDLAYTNHIGYNPDLIYEDQTLLIPTDCKTIDDGSCLKKHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW55</accession>
    <name>F9WW55_ZYMTI</name>
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            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857625.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13403244"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32234"/>
    <dbReference type="eggNOG" id="ENOG502S24K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="YEDTRKC"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="31329" checksum="CF8B2370AEE0725A" modified="2011-10-19" version="1">MGFLLGPSPNLQTTRIDFAQTPLTEYAGLYAVVIDNVLTPTECAALIAGAEASSNGQWERALVNVGGGRQERIDYIRSCSRIIWDQAEVAERIWKRVEDVPQVKEILRLENCPKIFGNGPVKRGEVWRFSRPNERMRVLKYVGGEYFKRHTDGSYATPDGSERSYFTLHLYLNSGGVPGEEEVPEIAPFEFAAGSGATAPAQLDGSALVGGATSFHSLSFEDKMDVHVRPRTGRVLIFQHRSLLHSGQDVEKGEKYTMRTDLMYALESTKSKTRSHMAGLDD</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856221.1">
        <property type="nucleotide sequence ID" value="XM_003856173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWG6"/>
    <dbReference type="STRING" id="336722.F9WWG6"/>
    <dbReference type="GeneID" id="13394626"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78442"/>
    <dbReference type="eggNOG" id="ENOG502SBMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162852_1_1_1"/>
    <dbReference type="InParanoid" id="F9WWG6"/>
    <dbReference type="OMA" id="AMTMDHR"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="8876" checksum="6956210CE60FA67F" modified="2011-10-19" version="1">MPLVVPGLQSKNGDKSSNWMEKLVGKKIGDSSNETTFAKTDLPKQHRIVKEGDMMTMDHNPDRMNIHTGEDGTVQKVTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWS4</accession>
    <name>F9WWS4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_107443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107443"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712140_0_0_1"/>
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    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="43258" checksum="14EFA865D70FE182" modified="2011-10-19" version="1">MRAATLVQTLIITELHDDNGPTIPSGGNTTTRTPIRIEGCYISTIKLLVRSLIYSPMLADHVRELYFGEDTPLLADLDSDGEELEDHGVEVEAIENYAEAVNASTSLSQEIRELVTNGLAEGEQPANMAMLLIACRKLEVLEVELLPGWNELIVGSVLDSAGRDPMASSESNEALPLSRLRELTVRCGQETAFLKMSELQWLIHIGQLETFRGNRLEIIQAADEGAYGEPCHIKHLRLTDSACDGESLRELLACCSSLETLQLEFGPACLVCYGWLSRSIIEFGQNLREICIDMSTLRLSAIAIYGKDDPDDRGFPNFEIPVLTDILPISLRVLELFDCATVQMEAMEKQLNAVWVDDRFEDLYRVRLRAREDKAEVTWDRAEGSHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWW4</accession>
    <name>F9WWW4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_53981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857075.1">
        <property type="nucleotide sequence ID" value="XM_003857027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWW4"/>
    <dbReference type="GeneID" id="13395394"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53981"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1609"/>
    <dbReference type="eggNOG" id="ENOG502SUWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171231_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWW4"/>
    <dbReference type="OMA" id="PTRVLRM"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12150" checksum="2A2C9258AF5A4837" modified="2011-10-19" version="1">MQSTRFLAANALRAQSASTSMLRSRAVPMLRMQPVRGFKSTPKRMAMPKEEQSAHTISQRIRTLKKIPPELIPIGIVLAAAIGAAVYSLGRKLVTDKTLRLTRQGKQADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX57</accession>
    <name>F9WX57_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856787.1">
        <property type="nucleotide sequence ID" value="XM_003856739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX57"/>
    <dbReference type="STRING" id="336722.F9WX57"/>
    <dbReference type="GeneID" id="13398525"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107761"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_3_1_1"/>
    <dbReference type="InParanoid" id="F9WX57"/>
    <dbReference type="OMA" id="HPRECIV"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="3">
        <location>
            <begin position="58"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="466" mass="52345" checksum="25F1EC1EDF39E9C8" modified="2011-10-19" version="1">MKQCILKGTKDRRPTNVDAFADLEKGYGTFDHDNQQSSQDGPNEPEEDFGSNWMSHLHDSTLLSALTIPGTHDSATSASHIPFIRTQSLSITDQLALGIRYFDLRCALRQNIPVMVHGLAYLNLTLASVLSDLTAFLSAHPGEGLVVQIKQDRKPSKSDISFSRAIYLELEAIRPYLRTLPTTPTLGEARGKIQLFRRYNLPRGIRGYGIDVTQWQDNPEEPFTIHHPWFRQQLTIQDHYSFTSGTSLPSLVTSKTTSVISLLNRAASDSDSPSHDDDEPDSAHWYINFTSAFEINVWYQIPPRTIAVGGYYFLRWVDGVNARLRAWVEVKGGGKGLGIVVMDFPESEGDLVEELILTNFEQGEKGSDVGWRRWWRGVGVGLVVGMAVGLLLMAVVLAWAMFMDEQTARVVVGYLGCIALRRLPCGLRASSVESFHRQFMIRLFELLIPPNVRWTSFHYCTDLAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX69</accession>
    <name>F9WX69_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    </evidence>
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</entry>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
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        <source>
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        </source>
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        <property type="project" value="InterPro"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXL2</accession>
    <name>F9WXL2_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855995.1">
        <property type="nucleotide sequence ID" value="XM_003855947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXL2"/>
    <dbReference type="GeneID" id="13403934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65233"/>
    <dbReference type="eggNOG" id="ENOG502QQMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_0_1"/>
    <dbReference type="InParanoid" id="F9WXL2"/>
    <dbReference type="OMA" id="CDFYAPF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40160" checksum="8EF3D1636E7CECED" modified="2011-10-19" version="1">MTAIFSQPPRTFPKHPRMFALHATPAPISSGQPSRSSHAADAATMSRVPIAALLRQETASSASTAVEHFSDQGRTYYRIQNDMYIFPSDDIEFERLDVIHSLIYQVALNNQLHVAVLRTNPRRILDIGYGTGFWMLDMETKYPGAEITGIDMEEPPAGVKSNGRLNFRSSVDFTAPRWPVEDSSVDLVHMAQLLGCVPNWSDHYTKAYRSLRPGTGQIEHVEIDWTPRSYASGFPHNATDLWNWWGWMLQASERAGKPLAYRDDTESLLEGAGFVDVSHKRVRVPLCGSDRRDRQEKQLAHGYQMTMGYTGSQSFTGMSMALFTRYLNMSPRDVEQICARALQVVQQGELPLYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY55</accession>
    <name>F9WY55_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anthranilate phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_31477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857271.1">
        <property type="nucleotide sequence ID" value="XM_003857223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY55"/>
    <dbReference type="FunCoup" id="F9WY55">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY55"/>
    <dbReference type="GeneID" id="13402842"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31477"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1180"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_0_1"/>
    <dbReference type="InParanoid" id="F9WY55"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="107"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="43854" checksum="191203B387B3B434" modified="2011-10-19" version="1">MPPSQTVNGTVSVSDLLKRLSTLESAKKVSAEEIAAAVALIFTNSLSPVQFGVLLWALHTTNLDHSADVLAACASSMREAAAQVDATALHTVVDGRRRPEGTYGGGLCDIVGTGGDGHNTFNVSTTASIISSALLMIAKHGNNSSTSMSGSADLLQHAPRPPIIAATTAGNLPRIYEKTNYAFLYAREWHPGMKYAAATRKEVPVRTIFNLLGPLANPLDDTGLVECRILGVARKDIGLNFADALRLGGAKKALVVCGEENLDELSCAGPSQCWYLHVPPGSGKGHVEITNFTLTPEDFGLPRHSLETVHGGKGPAENAEILMRILRGEMPDDDPVLHFVLLNTAALVTLSGVCDAEESNMGSGDDGKVIPEKGPGGLRWKEGLRRAIWCVKSGEALRQWESFVDVTNSMPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYC7</accession>
    <name>F9WYC7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_35055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857137.1">
        <property type="nucleotide sequence ID" value="XM_003857089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYC7"/>
    <dbReference type="GeneID" id="13395255"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35055"/>
    <dbReference type="eggNOG" id="ENOG502S47Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158780_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYC7"/>
    <dbReference type="OMA" id="LTICHTG"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP92113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="11013" checksum="51F82019EBE35E31" modified="2011-10-19" version="1">MAALAKQRLGNCPDTKLVLSGYSQGGFVCHNALSAQGLDGSKVAAVVCFGDPLNGQPFQGVDPSRVVKFCDTADNVCPGGQKSGAGWHLSYGSDVQAAAAFIKQAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYT1</accession>
    <name>F9WYT1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855879.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13403285"/>
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    <dbReference type="eggNOG" id="ENOG502SI7R">
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31442" checksum="59420366C38008BA" modified="2011-10-19" version="1">MPKARKSASGATSVVSSAMSSRLPSRAASPSAPRQRFRFFDLPAELRVRIYEDLLLMPEPVDLDPMNYRVIHPRLALFLVSRRMHEEAYRVFYAQPLRLFPFHGRFFETKKPLLTRLPARYRQVVNTIELRLGPGWSRPPKCQNVKPALGLMDCTNLRNMKILVQTDPSDTVFNGFRGRGATEDTYKWFCIDLLSGILEQVPSLETIEIDAWVKKDMPLVTALRRKVEEANKRLVWGRCLREREASEGSAERVALDGALASLSISNEAPRLVHVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ78</accession>
    <name>F9WZ78_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_89374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ78"/>
    <dbReference type="STRING" id="336722.F9WZ78"/>
    <dbReference type="GeneID" id="13402951"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89374"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_1_1"/>
    <dbReference type="InParanoid" id="F9WZ78"/>
    <dbReference type="OMA" id="MLTGEGY"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="587" mass="65483" checksum="B9A65BF60A866FB9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZI4</accession>
    <name>F9WZI4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_88650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855863.1">
        <property type="nucleotide sequence ID" value="XM_003855815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZI4"/>
    <dbReference type="GeneID" id="13403785"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88650"/>
    <dbReference type="HOGENOM" id="CLU_883408_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZI4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395223" evidence="2">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="315" mass="35272" checksum="3A9493FCB3D39B5F" modified="2011-10-19" version="1">MHLFSILAIVLPVTSALAADVEARYYNNPPKCGVQGYDKARPGKGERGGHVLGIGIDHILRLFCHQEHDEMHDGEHDEEQGDEHDKEHDKEHDADHNVFARDHNIFAHDYYNDTHHANVNHYLSHYHHRVPNYYYNILHYHGHNDLNNYQATDLPTFTARDLAQFCGDPAATFAAVFATQTPLPSSAASNSDITGMYIQLNADSFSNFGSIGAGLDSSMRFVVTETKWQARRPLRDPPHNFDDPVFGHKVILVLGSGSVSTEQAIHLQAMTSFSNHENLTTNIFPSNHDNLKLDSTSPPTMRDDPCPSVTPHFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZJ7</accession>
    <name>F9WZJ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_98153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857770.1">
        <property type="nucleotide sequence ID" value="XM_003857722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZJ7"/>
    <dbReference type="FunCoup" id="F9WZJ7">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZJ7"/>
    <dbReference type="GeneID" id="13403341"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98153"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="InParanoid" id="F9WZJ7"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="25138" checksum="5B530C2523B93D28" modified="2011-10-19" version="1">MAAIRSLSKPALAVIDMQEDFCEPNGPLAVKDGRSVAPIINKLMDRPGFALKIGTRDFHPRNHVSFASNHKDMTPFTSKHMIHNPYNEKETQTTLLWPDHCVQGTPGVLILPELHREKLTHIVNKGMDPLLESYSAFGPPFRHPEVSMSGLTAILKENGITDIFVVGLAFDFCVKHTALDAVEQGFKAYVIEDATRAVDQSEESLKAVKEELVAAGVKIVGLESEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZM5</accession>
    <name>F9WZM5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_65114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855937.1">
        <property type="nucleotide sequence ID" value="XM_003855889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZM5"/>
    <dbReference type="FunCoup" id="F9WZM5">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZM5"/>
    <dbReference type="GeneID" id="13403271"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65114"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.244"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZM5"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="340" mass="37970" checksum="BA6146C360FC1989" modified="2011-10-19" version="1">MRPILLQGHERALTQVKFSKEGDLIFSVSKDHMVCAWYSANGERFGTYKGHQGALWTVDVDPTTTLLATGGADNTIRLWEVKTGKLLKTWEFGTAIKRVEFSEDGRQLLGVTEKRQGQLSSIVVYDINQDVDGEQPDEQSLRIIVDDVPKVTVAGFSYLSQFIISGHEDGSVTQYDAKSGEEIFHTFPHDDGMQVTDLQWSSDRTYFITSSKDKTAKLIDAKTLDVLKTYVADTPLNSAAITPEPTNYVILGGGQAAMDVTTTSARQGKFEARFYHKVFEEEIGRVRGHFGPLNYVAVAPTGTCYCSGGEDGYVRVHHFDSPYFSFKFEVEKESEREGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0A1</accession>
    <name>F9X0A1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_53498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857221.1">
        <property type="nucleotide sequence ID" value="XM_003857173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0A1"/>
    <dbReference type="STRING" id="336722.F9X0A1"/>
    <dbReference type="GeneID" id="13399160"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53498"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1284"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="F9X0A1"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="54"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="426" mass="46422" checksum="E31A896E778A5F6C" modified="2011-10-19" version="1">MLAKSALQRAAAAPRSAVAQQSIRAASAWSKVPQGPPDAILGITEAFKKDSNSQKINLGVGAYRDDKGKPYVLPSVREAEQKVVKANLDKEYAGITGVPDFTKAAALLAYGPDSTPLKEGRIAITQTISGTGALRIGGAFLERHYPHAKAIYIPTPSWANHKAVFLDSGLQVKQYRYYNKDTIGLDFDGMVADIKSMPKNSIVLLHACAHNPTGVDPTEKEWKAISDAVKEGGHYPFFDMAYQGFASGDTDKDAFALRYFLKEGHLPCLAQSFAKNMGLYGERVGAFSIVCESAEEKTRVDSQVKILVRPLYSNPPVHGARVASTILNDPALNKQWLGEVKDMAERIIKMRALLKDNLEKLGSTRKWDHITSQIGMFAYTGLTADQMTELAEKHSVYATKDGRISVAGITSENVGRLAEAIYKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0H6</accession>
    <name>F9X0H6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_32504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856568.1">
        <property type="nucleotide sequence ID" value="XM_003856520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0H6"/>
    <dbReference type="GeneID" id="13398975"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32504"/>
    <dbReference type="eggNOG" id="ENOG502S03T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069181_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0H6"/>
    <dbReference type="OMA" id="QWYARIW"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="223" mass="25223" checksum="E2514E987E0F69C9" modified="2011-10-19" version="1">MGIVRTALAVTGWTTLGSTAGFLLWTRKSHIVDVPPTDYIFNHTLYSRYNPNNAPVTQDLCVRRVPLANIRPELLEKEGKLVEAFSAGLWGGLGYAYQRRFLEKKYRADPVTADHLWDKEQLRASTYEVGTKITDHFEVVAKSPESIIVRCGDSPRNKDVRESDGLFEMQAEIKKDEGVAEFGLKSVFYEGKPPAPPMSAWIQWLHAQYDKVLMETAISNCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0T7</accession>
    <name>F9X0T7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_84267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856921.1">
        <property type="nucleotide sequence ID" value="XM_003856873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0T7"/>
    <dbReference type="STRING" id="336722.F9X0T7"/>
    <dbReference type="ESTHER" id="zymtr-a0a1x7rhi5">
        <property type="family name" value="MpaH"/>
    </dbReference>
    <dbReference type="GeneID" id="13398240"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84267"/>
    <dbReference type="eggNOG" id="ENOG502QQ4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0T7"/>
    <dbReference type="OMA" id="FGIRGIW"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="433" mass="48862" checksum="9B2EFF224E4F636F" modified="2011-10-19" version="1">MATARFRIKEHTLPASHIRDYARGTADDQEAVLHIAIKQYIPIDSTHEDEGDVTVIGAHANGFPKELYEPLWDDLYERLKAQNVKIRSVWIADVSHQGQSGVLNEHKLGNDPSWFDHPRDLFLMVNHFRKHMKRPLIGIGHSAGGNHLINLSLMHPRLFTTLVMIDPVAQRLQATEGSSGIAGASTVRRDRWPSRKDARAAFGRSKFYQAWDPRVFDKWIEHGLRELPTLIHPGSQTAKTTIPVTLKTTKHQEVLTFLRANFPTSEYPDPSNNANPITHIDVDPATGPNSPFYRPEPVATHARLPFVRPSVLYLFGGKSDVSTPMLKADKMASTGIGPGGSGGAKKGRVKEVTFQDIGHLIPMEVVGRTADTATEWIVPEIERYRRLEEEHNREWSKVPKQMKPQMDEKYKKMITSNWASELKMGYVQKVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1V9</accession>
    <name>F9X1V9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_84830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855128.1">
        <property type="nucleotide sequence ID" value="XM_003855080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1V9"/>
    <dbReference type="FunCoup" id="F9X1V9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1V9"/>
    <dbReference type="GeneID" id="13400070"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84830"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.988"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_0_1_1"/>
    <dbReference type="InParanoid" id="F9X1V9"/>
    <dbReference type="OMA" id="QNAHYID"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="233" mass="25436" checksum="71405AD3D66863BE" modified="2011-10-19" version="1">MEDSSLHKEAEGEQISKLLDRIAYLRKRSGDEQRILIAVAGGPGSGKSTLCARLLQEAQKKGLHDMVAVPMDGFHFPKSHLAALQDPAEAFARRGNPLSFNAAKFVEAVATLKATASGLAPTDIALPGFDHAVQDPVDNEIIVLASAKVVLLEGNYVLLNEKPWNQISDMVDDRWYIDVPRDVAKLRLIERHLRAGIETCSVAAAARAESNDLMNADYIASRLIEPDMVIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Z8</accession>
    <name>F9X1Z8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_103011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854709.1">
        <property type="nucleotide sequence ID" value="XM_003854661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Z8"/>
    <dbReference type="STRING" id="336722.F9X1Z8"/>
    <dbReference type="GeneID" id="13395878"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103011"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.46"/>
    <dbReference type="eggNOG" id="ENOG502SHGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071111_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1Z8"/>
    <dbReference type="OMA" id="TMQTEME"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="296" mass="33474" checksum="EDDCBE19DFA4BB45" modified="2011-10-19" version="1">MFKRSFITPKDRAGKARKISKRSFRDDAKQRLREQLNNTASPETSPSLGGCSPKLNSAIVTIAVGRDQRLFAAHEDVLARSPWFAEACRAQFFESATQRRISLPDEEPEIFSAVLEFLYKGDYYPRLMHDRKRNTWSLEDAAQDLTTTPISTSPRVESQAKKTGSSNESASVFHHGVNDFILRDTVVYCTALKLQLPELQRLALRKQGLQSGIDVATILRSARFAYANTPPSDSRLRAHYLALIIRSRKTFKRSGTMQMEMEKGDTQMFFDLFVAMCNHIDDVVEFGSGRTPDLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X288</accession>
    <name>F9X288_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_99090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854906.1">
        <property type="nucleotide sequence ID" value="XM_003854858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X288"/>
    <dbReference type="STRING" id="336722.F9X288"/>
    <dbReference type="GeneID" id="13403533"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99090"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="F9X288"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55031" checksum="C83E5DC6CF164C22" modified="2011-10-19" version="1">MAPSSTILVNNSNSLEIFDQTPQAQSFNPSKTSESRVFHRCLHSDPLHVVGAKGHYLTLSNGQEIFDASGGAAVACLGHGDVRIQDALMEQMNQVSYCHSLFYATHAAEDLAKLLIDSTDGEMARAFLISSGSEAMEAALKLARQYHLEKASPEPSRVHFISRHQSYHGTTLGALAAGGHVARRAIFEPILSINTSRVSPCYAYRAVHDLTEANETMYIRKLEAELDLEFKRVGSENVAAFIAEPVVGAALGCVPPSPGYFKAVRKVCDKHGALLIFDEVMSGTGRVGPESSEKYRKPLHAWQDPLIGVVPDIMTMGKGLGGGYMPIAAMLANRRVVNALCNGTGAFSHGQTYQGHPLACRAALQVQRIIRDSDLVANVREQGAVMSRLLHKRLDDHPFVGNIRGRGLFWGIEFVKSKDTKEPFAQSVGIAMGIHELGMQRPYNISLYPGTGCADGKSGDHIILAPAYNITADEISQVVDTTVTVIERFFSEMEVERDADDSNGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2D6</accession>
    <name>F9X2D6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_84685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855010.1">
        <property type="nucleotide sequence ID" value="XM_003854962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2D6"/>
    <dbReference type="GeneID" id="13403427"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84685"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="InParanoid" id="F9X2D6"/>
    <dbReference type="OMA" id="RWQGTLF"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855565.1">
        <property type="nucleotide sequence ID" value="XM_003855517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2U8"/>
    <dbReference type="GeneID" id="13403505"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17966"/>
    <dbReference type="eggNOG" id="ENOG502SSD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_4_1"/>
    <dbReference type="InParanoid" id="F9X2U8"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="109" mass="12764" checksum="A2CF27494BD1F7F3" modified="2011-10-19" version="1" fragment="single">KAGLSVFHQLHCLGTLRNFIWDLMYDRVDKEKLLRSWPKDVTTPTYDEAIHGMWHIAHCMDYLRQGLQCSADLSLEFVREFSGPAVVDGLNYPHVCANWDEVWTYAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X348</accession>
    <name>F9X348_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855432.1">
        <property type="nucleotide sequence ID" value="XM_003855384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X348"/>
    <dbReference type="STRING" id="336722.F9X348"/>
    <dbReference type="GeneID" id="13400979"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108182"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656427_0_0_1"/>
    <dbReference type="InParanoid" id="F9X348"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17592" checksum="8939CD01852CE5BF" modified="2011-10-19" version="1" fragment="single">MSGGIEEPYAIASLPTPFDAEKGRILAAPIHSISGSRKRKRHEVAVGIDGESLNIYSIQNQSTVSSYALSPQSYLAAPPCSIYCKRAKPTQPQRRTYLALRDGVTSSKARLVNITEELGKLRSEEREPRAPAKRERKLRHSNISGLEVVQFGEDIDSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3A8</accession>
    <name>F9X3A8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_67680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854688.1">
        <property type="nucleotide sequence ID" value="XM_003854640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3A8"/>
    <dbReference type="GeneID" id="13403768"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67680"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="F9X3A8"/>
    <dbReference type="OMA" id="CNATSYM"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="522" mass="58170" checksum="A4EC3830C6F7C3DF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3U3</accession>
    <name>F9X3U3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1770-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855421.1">
        <property type="nucleotide sequence ID" value="XM_003855373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3U3"/>
    <dbReference type="GeneID" id="13400968"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37650"/>
    <dbReference type="eggNOG" id="ENOG502SAKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101474_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3U3"/>
    <dbReference type="OMA" id="GWRHWNR"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17409" checksum="CCEC0C8DB56561A1" modified="2011-10-19" version="1">MADLQDTAIQFAETIQTAHINENPSVERDLAPETSVDFKQPVTLDRSGDHSEELDEVDEDEIPLSILRPVPEARRQPPHLQLPDLRFEQSYLKSISEASDWRMVAYVTIKDQVLMPLLQGMVWTLVVAGWRHTNSTAKFSGQTVGARIRRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X408</accession>
    <name>F9X408_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_99312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855301.1">
        <property type="nucleotide sequence ID" value="XM_003855253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X408"/>
    <dbReference type="STRING" id="336722.F9X408"/>
    <dbReference type="GeneID" id="13400260"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99312"/>
    <dbReference type="HOGENOM" id="CLU_1788354_0_0_1"/>
    <dbReference type="InParanoid" id="F9X408"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="15568" checksum="A0D31325FBD0E1C6" modified="2011-10-19" version="1">MPAEPLSAAARRRNGRFPACEPCRKAKIKCDNERPVCKRCLYRQKASSCFYHPAPLTKARRSSADALTHGVNVSTVIGPSQASAVSYGVAAPVQDNAVIDNGVVRSLSNLCAAFRSYDAQDHLASEETISAVVDVLSRVFGISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4F4</accession>
    <name>F9X4F4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_27804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855506.1">
        <property type="nucleotide sequence ID" value="XM_003855458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4F4"/>
    <dbReference type="STRING" id="336722.F9X4F4"/>
    <dbReference type="GeneID" id="13399618"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27804"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_2_0_1"/>
    <dbReference type="InParanoid" id="F9X4F4"/>
    <dbReference type="OMA" id="WVFPTAP"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="211" mass="23686" checksum="F78E55624D7960C6" modified="2011-10-19" version="1" fragment="single">VIFLHGRDSTAKEFAEEFFESQASGEETLLDFFPSVKWVFPSAGLLNSARFGCELSQWFDMHNTENPHEQEDDQHLLPSMKRIQDIIAQEAALIGHDKIILGGISQGCAVAIHALLSGHRQLGGFIGLCSWLPKREDIKRIDRTTNQAIKTPLLLCHSQDDDVINVTFGIELRDSLKSIGMKPRWCEYAPGAEMPHWVNEPQGVDDMVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4H8</accession>
    <name>F9X4H8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854993.1">
        <property type="nucleotide sequence ID" value="XM_003854945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4H8"/>
    <dbReference type="GeneID" id="13399633"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90839"/>
    <dbReference type="HOGENOM" id="CLU_1095012_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4H8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="254" mass="30117" checksum="A1A1B8D78BDD5AE9" modified="2011-10-19" version="1">MAAIQTRILELQQDPERAKRSERKAGQKNLEAAEKFSSVNFEFRYLNHMGAGYREQPGQKTATEIELDRLKSIMHDAESYWLATQRKSKGIHAVALERTKQNNEEIEREAEDERCRTEEMHRQRREEKRKRYQAARAERKVREQEAQKRATAAKEEEEAKARERRRRFESGSKWEEYTNAQNRQREENRRSNFHPYLPEPVVFTTRVPRRDPNAAAKWRVATEDFSRHLNRTSLNHPGKAAVRWSNAAVRLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4J2</accession>
    <name>F9X4J2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855494.1">
        <property type="nucleotide sequence ID" value="XM_003855446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4J2"/>
    <dbReference type="GeneID" id="13403434"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90850"/>
    <dbReference type="HOGENOM" id="CLU_740119_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4J2"/>
    <dbReference type="OrthoDB" id="10671539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="111"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="374" mass="41251" checksum="D38D4F9B4F669FD4" modified="2011-10-19" version="1">MSVIEVAGLVLAIIPIITSALGALDRAPDKYARPDIVDSLKAVYGDVYDAIESDLIHIRILMADLCERLGLGHIIETWALSAPGSTSMLFSTVHTIENDSAPELHSNPLARPLVSDICAEVEPRPQKSSSPVLEIHFSLGSDPGSLQMSQRPTVQAVLKDSISLYQLLEQPAPQSGYFAPRRLGEKDRRFLATRIALYALQLQGTPWTSGKWTGHAILFVSRESPELPRPSISKSFQRSAQATSLGADNQAQHVYSHRFFLALATLLMELYVGEAMDEDPSSAGTSHQRDSPDFTKLVALQILRERRQSDTSDAYQKAIQYCLASALNAQFTLDMDVDTAIEEIVYPLVREYEIFTGHPPSRNAVALEEGSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X592</accession>
    <name>F9X592_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_70288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854010.1">
        <property type="nucleotide sequence ID" value="XM_003853962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X592"/>
    <dbReference type="FunCoup" id="F9X592">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X592"/>
    <dbReference type="GeneID" id="13395458"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70288"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.866"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="InParanoid" id="F9X592"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000172">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="29232" checksum="1070179FD4056E4C" modified="2011-10-19" version="1">MATHQPFPSRPYTSGLTRGTGGAQNVNTFGTTPYASQTPFNPQQSQQVPLPQQSNPAGLGATQQQREAQRLERERHERAERERREAEERETLEQLSEEQREEINEAFSLFDLDKDSHIDYHELKVALKALGFEVPKSELLQILQSHGVPASALQTSASTSKAPVPQQPTFSGPSRLLLSHAAFTSVAAQRILARDPREEILRAFELFDADGKGRIELQDLRRVARELGEGLQEEELAAMIEEFDIRGEGGIGRDEFVGICMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5M3</accession>
    <name>F9X5M3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108514</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9X5M3"/>
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    <dbReference type="eggNOG" id="ENOG502S698">
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    </dbReference>
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    <dbReference type="InParanoid" id="F9X5M3"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="175" mass="19268" checksum="0DDB8324D5DB1427" modified="2011-10-19" version="1">MPKKRSFNFKQLQGASSGKPSTDGNDGKPTVNERLGELRKIEGKDAARRKRELAENVNQSRPAQLLRFAYLLGIEHDPNPFEQSPSLLHLALKTAAEHWDLFDEDDLPALAAELPLRLRTRLLSYIGYYGPAISISVLESMLGGDEAVTQLDLAASIALMSEQEAPISILALTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Z1</accession>
    <name>F9X5Z1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91342</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853643.1">
        <property type="nucleotide sequence ID" value="XM_003853595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Z1"/>
    <dbReference type="GeneID" id="13400898"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91342"/>
    <dbReference type="HOGENOM" id="CLU_581674_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5Z1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="52004" checksum="E3B3FDAEC6DBD156" modified="2011-10-19" version="1">MLVFACVVDFASRLDRYKTCVLADAGAEDLRQDRRVPSGGIARLSTREHPPSPLLISPEQQHTVGKSLNDQLRLLDDAFLPTMTPTNTWLATTPESTPSTVPVFDIIEPLSDVATRQRISLDLAFQRDPTQAIQRAASADIHQESARLATPSSAIRSSSLPPAVAAQPRASPTFCPSSLKDSTSDEPTPVHRAASDPCNPPTRSRAATVIDSNIEDATSNHELLQTYADSDGGDEDNQETSMPDDLFQPLERQLTTRRWRSDDDTESVDTERQDSAWDQDTGGADLTDIDELNGSPEVELSDLEDLNEGREAMNDVQVEIAVEMDEDSGDGKDAMDDWGSVHSVAEQYEEGIETLDDGECEESPALESMPSFQIRLFDPESSMYGEIDEYREMPALIVEEWSGEVKEMPSIQEEETELQDSQEEFPASIKRRLTETHVTFPDAVPRQASKAVLRVPLSQHARSGRLPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6E0</accession>
    <name>F9X6E0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_38706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
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    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
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    <dbReference type="eggNOG" id="KOG2951">
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    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
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    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0008934">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Inositol_monoP_metal-BS"/>
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    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="297" mass="32544" checksum="F8A38B0A46336CB6" modified="2011-10-19" version="1">MYTVDLQAVHDFLVEVAYKAGETIRSATPAVTGHGTKKNSADLVTETDQAVEKMVSDMLKEKYPDFEFIGEETYHPDLALSSKPTFIVDPIDGTTNFFHGHPYVCVSLGLAIEKKPVVGVIYNPFTNALYTGIKGKGSYVTDATHDHVRLPLREPEPFEDLSHCLVAVEWGSDRDGTDYETKVATFKKLCASKALGGAMVHGIRSLGSAELNLCGVAAGHLDVYWETGCWAWDVCAGWVILEEAGGRMFGAMKGDYEPKVDQRRYMAVRGGEGQQKIAEEFWGCVEGKIEVGYDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6L6</accession>
    <name>F9X6L6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">Stress response protein Rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_103564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854610.1">
        <property type="nucleotide sequence ID" value="XM_003854562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6L6"/>
    <dbReference type="GeneID" id="13404008"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103564"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.139"/>
    <dbReference type="eggNOG" id="ENOG502QSE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028606_2_0_1"/>
    <dbReference type="InParanoid" id="F9X6L6"/>
    <dbReference type="OMA" id="TEPRYMV"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391399" description="Stress response protein Rds1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="55426" checksum="3C6194D0E26D9BBD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6Q2</accession>
    <name>F9X6Q2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_56270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854589.1">
        <property type="nucleotide sequence ID" value="XM_003854541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6Q2"/>
    <dbReference type="FunCoup" id="F9X6Q2">
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="182"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="388"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="650"/>
            <end position="737"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="25"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="747"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
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            <name>ATP</name>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EGP89565.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="784" mass="86510" checksum="D99C74466A93C673" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X794</accession>
    <name>F9X794_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_99625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854333.1">
        <property type="nucleotide sequence ID" value="XM_003854285.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X794"/>
    <dbReference type="STRING" id="336722.F9X794"/>
    <dbReference type="GeneID" id="13395519"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99625"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.728"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="InParanoid" id="F9X794"/>
    <dbReference type="OMA" id="RYNVANY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="425" mass="48492" checksum="DD13BD746783E9BB" modified="2011-10-19" version="1">MSRKDSVGKLMNWFGYGAGAECLPKAVNDDNSPIRALPSNWYNSPEMFDLERRAIFSRKWQLITHKNRFKQPGDWLKWTITGLEVVLSMDRNNKINGFHNVCRHRAYPVVTSGDSGNSKIFSCKYHGWSYGLSGKLAKAPGYDKLDDFSKENNSLYPIHVRIDHQGFVWINLDAKSTPEVAWEDDFEGVDTQERYGIYNMDDYEFDHSWQMDGDYNWKILADNYNECYHCATTHPDIGALADLHSYSVATVKGQIIHDAATTEEQRANGLVVASTYYFPNVSTNISPHFFMIQRFVPHSADKSTMSYQVFRNKHSSDADFDLVSNIYKRIMSEDKALCSAAQQNLNAGVFTNGELHPKYEKGPLHFQKTCRETVVGWREKELREGGTEIWPARPTLPETANVSIQDEDFCKGLSCSTQPPEGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7E9</accession>
    <name>F9X7E9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7E9"/>
    <dbReference type="GeneID" id="13404449"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92156"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1070"/>
    <dbReference type="eggNOG" id="ENOG502SKHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727941_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7E9"/>
    <dbReference type="OMA" id="PLIHVVW"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395540" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45865" checksum="668E1398B93B0B0C" modified="2011-10-19" version="1">MKTFSLLSVLAALSDAAPQDLHSALSPRQAALRTSRYFPKPFPPPTNQPAPSPFTIQSGEPVYPQLKATPQLLGLVSDPAFSRDSCGTTRLNNRTLWACRDSQYVVNGAVNTNSLLSSTASWSNSSAAGQPTLLSLKSTDNKLNTTVLKQYGANSNSQAFYPVNANKYCSSQGGCSDGSRYAIWPDSPPMRTSYRIGYTWIRATHINQDLGLVEPNPATILYKVTAPSAASGNTLPSVTVINETFWGRNEIAYGAYGNVVRNGIAYLYGQANGTVSLAKVPVGSVENRSAYRYWVNGDWVTTAPKIGADGIRIENVSVGGQGTYFWSQGWNSYVWIGGNQYPGATMYITTAPDPAGPWITPIRFYDGPNGNFSLPAYSIQAHPAMMEFNPSLKSMLLTYTKVDQDSRGNAVYSHPLIYAQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7F5</accession>
    <name>F9X7F5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_92162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854113.1">
        <property type="nucleotide sequence ID" value="XM_003854065.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7F5"/>
    <dbReference type="GeneID" id="13404518"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92162"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1078"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001011_1_1_1"/>
    <dbReference type="InParanoid" id="F9X7F5"/>
    <dbReference type="OMA" id="LIMDPFD"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="247"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="652"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="884"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1582" mass="175898" checksum="0680285043B6EC1F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7H8</accession>
    <name>F9X7H8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_103966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854126.1">
        <property type="nucleotide sequence ID" value="XM_003854078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7H8"/>
    <dbReference type="STRING" id="336722.F9X7H8"/>
    <dbReference type="GeneID" id="13404465"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103966"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1100"/>
    <dbReference type="eggNOG" id="ENOG502SJG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_0_1_1"/>
    <dbReference type="InParanoid" id="F9X7H8"/>
    <dbReference type="OMA" id="WADIPHW"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39173" checksum="109C6D481CF51C56" modified="2011-10-19" version="1">MSADMDQLQGMQAKAKSMASAVAASLPEAIPWSKSYHLPTDLKNYARLRIVRVVAAGVVMLWCASVFGLFASATKVKISLPSLVDGDVLDRNSTERLPLIPPNIYQIFLGWEPDKAKDYSDNILSWIGKSPSYSYTLLDDEGAQSIVSKLAESSTHAHILPVFYAMGRRVMRVDFLRYLLLALEGGVYSDIDTELLKPVHDWVPKALQNSTRLIVGIEADHSPPIAGTTYETQFCQWTLAGAPGHPVLWRMVDKVLDTIRTRPFSAHSVDYSNDEVLGIGGPAGWTETIYEYLSDEAGEPVTWRNLTGMTEPKLFGDVLVLPIDGFASNVGHSGSHGDQAPGAMVKHHFKGSWRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7L5</accession>
    <name>F9X7L5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_103593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853688.1">
        <property type="nucleotide sequence ID" value="XM_003853640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7L5"/>
    <dbReference type="FunCoup" id="F9X7L5">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7L5"/>
    <dbReference type="GeneID" id="13395761"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103593"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.195"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="InParanoid" id="F9X7L5"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="12">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="154" mass="15822" checksum="D2CDF327003D0A31" modified="2011-10-19" version="1">MVKAVAVLRGDSNVKGTVTFEQTSEGAETTITWDITGNDPNAERGMHVHAFGDNTNGCTSAGPHFNPHSKTHGAPEDSERHVGDLGNFKTDGQGNGKGSVTDKLIKLIGPESVLGRTVVVHGGTDDLGKGGHEESKKTGNAGPRPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7P3</accession>
    <name>F9X7P3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_39200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854559.1">
        <property type="nucleotide sequence ID" value="XM_003854511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7P3"/>
    <dbReference type="GeneID" id="13395746"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39200"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.227"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="InParanoid" id="F9X7P3"/>
    <dbReference type="OMA" id="YVARMEQ"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="415" mass="45168" checksum="44BB2BDEB5689074" modified="2011-10-19" version="1">MSQDQRQYEIVVFGATGYTGKYTAEHLTTYAPTDLKWAIAGRSEAKLKAVADEIHSLNPDRLAPGIEIAELNKQDLVKLAKTTKVLISTVGPYHKYGAFAFEACAENGTHYVDCTGEVPWVYDMVEKYDALAKKTGAIMIPQNGMESAPSDMMCWMLVNHIRQTLSVGTAEILDSVYSLKGAPSGGTLDTLLTLFDTYSLSHFAKSMNPWSLSAVAPPQETAGKPLLENITGIRTDSDLGILTDSLQGPSDIVIVNRSWSLYDGGKFYGPKFKISIYTKVSSNLQAFLMHLALTLGTATLLLPPVRWLLKKFVYQPGQGPTKEETTNDHCEWRAVANADVTDPNDPKRASGTMAYHGSMYALTAATLSEAAITLARDKTFAHELGGGVLTPATLGAPYMERLQKAGLKTEVKTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R4</accession>
    <name>F9X7R4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_22858</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853803.1">
        <property type="nucleotide sequence ID" value="XM_003853755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R4"/>
    <dbReference type="FunCoup" id="F9X7R4">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7R4"/>
    <dbReference type="GeneID" id="13395646"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22858"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024136_1_1_1"/>
    <dbReference type="InParanoid" id="F9X7R4"/>
    <dbReference type="OMA" id="GEFRFCK"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="438" mass="48815" checksum="D364D2CCEE4C7164" modified="2011-10-19" version="1" fragment="single">LAPTSASHTPSPPFHRRRKSWARRFERCCCKTVSYFPLSFVYGLTTWATYVSVGVSVVGHPTILSYLQAALAFTLYALGNTSYTIAVFTNPGSPIDPKFDGSRSTRRKGGDVGGRHARSTIGPGADMTSVTAKSDGKQRFCKKCQCIKPDRAHHCSSCGKCVLKMDHHCPWLATCVGLHNYKPFLLFLIYTSLFCWVAFAISAWWVWAAITDNEQMEQSILVVNTILLSVLAGIIGLVLSGFTGWHIYLVLTGQTTIESLEKTRYLTPLRQTMEHQFQSQRTYLSADGTHDPAYSPAEEQPLTDRIKEFHANALPGILRPEEGDASLNPSPSRSPAPDTRLHNSHPSAGSPAQQSLHRSYADLERDRENERYNSYLDEQASASLPNAFDLGYRANLLHVFGGNPLYWALPICNTSGDGWKWDVSPDWVRARERLASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Y8</accession>
    <name>F9X7Y8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_70208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853982.1">
        <property type="nucleotide sequence ID" value="XM_003853934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7Y8"/>
    <dbReference type="FunCoup" id="F9X7Y8">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7Y8"/>
    <dbReference type="GeneID" id="13395481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70208"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.812"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="InParanoid" id="F9X7Y8"/>
    <dbReference type="OMA" id="DWADWYS"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395400" description="Initiation-specific alpha-1,6-mannosyltransferase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45366" checksum="E5880731272DCD1E" modified="2011-10-19" version="1">MLTFRRALLVAAVVLTCFLFLRNSHPSQTNAYKPSNSPKPTGSYIDNRKIVEASPKPAEHASEEHPKPVISQQKEESHIALSDKKVRPQIPLADLKAKTLRQQLAYAFPYDVEAKFPAYVWQTWKTTPASGAFPEEWRAAEASWTQLHPDFVHEVITDSVAVNMVRHFYASLPEVQEAYAALPAPVLKADFFRYLILLARGGIYSDIDTTALKSAVEWVPTEVSRETYGLVIGIEADPDREDWHEWYSRRIQFCQWTIQSKPGHPVLLDIVAAITEETLRRKRAGEFSSRHMKKVMKDVVEFTGPALWTDIVFKFFNNPDYFDMSTSKGNITWRQFTGITQAKKVGDVVVLPITSFSPGVQQMGAMDIDDPMAFVHHKFDGSWKPENLRHIGEQTENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X825</accession>
    <name>F9X825_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_92214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854141.1">
        <property type="nucleotide sequence ID" value="XM_003854093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X825"/>
    <dbReference type="STRING" id="336722.F9X825"/>
    <dbReference type="GeneID" id="13404487"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92214"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1136"/>
    <dbReference type="eggNOG" id="KOG2064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013388_5_0_1"/>
    <dbReference type="InParanoid" id="F9X825"/>
    <dbReference type="OMA" id="FVKCIPK"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="5">
        <location>
            <begin position="237"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="471" mass="52003" checksum="076477CE4F673E44" modified="2011-10-19" version="1">MSTEYTLPCSPKYLCEDRFSILDSDELQVPFWPVFAELLKQPTTTPTQVIDLLETIAVTLRQKSSTDYGFLRDFMRTKLAPDFFSRTWPSVVDLSLQLPVLFPICTLPILSAGQASLQLTRRQAACLVTHQFLCTLAAPTWQDGYQDFHIWYSAEQPHARAVDAYLTALFKYFDRLGGPAETTPLSCSAEVWPITYTLTDNDEPANHAAEYLIPFETQHLDAASTAPFLLGLPDGASVISANKFIGFGRTGTQDEVHVGCSPEACPAVLVTPPLGDGDVMVVVGAEAMITIEGYGRTAQCGEVLPPPLSENAHDHRELWSKRTMLFMDALELDLEGRDEGLPDLQPGKVERELRKAYTAFRSSQNTSSGQRFNVVNTGFWGCRTFGGNPSVKTMIQWCAASKAGCGSMEFICSGEEQEAFGKRMMLFVDAVRMLRVKTTVLESVLLELLTQDVSPGEDALDVVLVRLKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X893</accession>
    <name>F9X893_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_85600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
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        <property type="protein sequence ID" value="EGP87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852855.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85600"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9X893"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
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    <dbReference type="GO" id="GO:0030686">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
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            <end position="502"/>
        </location>
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        <location>
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            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
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            <end position="725"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87879.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="770" mass="84962" checksum="C9AAD5C179A4C5DE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <location>
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            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X901</accession>
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        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
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    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_70984</name>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852949.1">
        <property type="nucleotide sequence ID" value="XM_003852901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X901"/>
    <dbReference type="FunCoup" id="F9X901">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X901"/>
    <dbReference type="GeneID" id="13400433"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70984"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.332"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="InParanoid" id="F9X901"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="84435" checksum="9A1F0B7BBDB83E41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9E1</accession>
    <name>F9X9E1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FAE4</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_70803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852884.1">
        <property type="nucleotide sequence ID" value="XM_003852836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9E1"/>
    <dbReference type="GeneID" id="13397205"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70803"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X9E1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="559" mass="59875" checksum="80FCF6C760B55875" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9G1</accession>
    <name>F9X9G1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_85593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852895.1">
        <property type="nucleotide sequence ID" value="XM_003852847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9G1"/>
    <dbReference type="STRING" id="336722.F9X9G1"/>
    <dbReference type="GeneID" id="13400640"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85593"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.213"/>
    <dbReference type="eggNOG" id="KOG4170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="InParanoid" id="F9X9G1"/>
    <dbReference type="OMA" id="WTIDMKK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="13729" checksum="39C06E304309D963" modified="2011-10-19" version="1">MGLKDDSWPSSAAFDAISDALNSDKERKDAVKQGGAVFAFNLKNAQGQEQAWHIDLKETGKVGKGAAPEGKKADVTLNLTDASFQQLIDGKANAQKLFMSGKLKVKGNVMKATKLDPILKKAQNKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA87</accession>
    <name>F9XA87_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_85716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853412.1">
        <property type="nucleotide sequence ID" value="XM_003853364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA87"/>
    <dbReference type="FunCoup" id="F9XA87">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA87"/>
    <dbReference type="GeneID" id="13397319"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85716"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.437"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_1"/>
    <dbReference type="InParanoid" id="F9XA87"/>
    <dbReference type="OMA" id="WVGVETK"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070635">
        <property type="term" value="F:nicotinamide riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070636">
        <property type="term" value="F:nicotinic acid riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006216">
        <property type="term" value="P:cytidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="381" mass="40386" checksum="33DD4CB3C649DE4D" modified="2011-10-19" version="1">MTSPTPIPLWLDLDTGHDDAFALLLAAHNPVLYLLGCSTVYGNAPLSHTTSNTLSILTALHRTDIPVYPGASKPFCRAEASAADIHGESGLDGTTLLPAPAVDAKTDVPAVEAMYTALMVQPKGAAWIVATGCLTNIALLFAIHPDLVDHIAGLSIMGGAVGDGFTDAPMGTVKGESEDQRFGNWTRWAEFNIYIDPESAAAVFSNPILAKKTTLVTLDLTHQFLATKEVQEGLVHGFDRNPEPDGKAVGEEGASGPSNTRKLFLEILTFFAKTYAEVFGLTAGPPLHDPLAVAALLPGLLFYTTTGTAEGEEERFEVSVVTEGEHGAESHVRNGGSQCGRTVVRKLGQGEEGVRVPRGVDGEKMWKVLEGCLGRAEAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAC9</accession>
    <name>F9XAC9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_40912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853274.1">
        <property type="nucleotide sequence ID" value="XM_003853226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAC9"/>
    <dbReference type="FunCoup" id="F9XAC9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="13399331"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40912"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023057_1_1_1"/>
    <dbReference type="InParanoid" id="F9XAC9"/>
    <dbReference type="OMA" id="GTLCEFY"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48282" checksum="486955428BA7FE17" modified="2011-10-19" version="1">MSYNPFGRAGPSRPPPKNPRPPANGVQRQTAAQLKEHSALFTTYEHLPNQERADAALLMLRKVASIVKPIMQKHHWHVQVLAEFLPKEQSLLGLNINKGYKICIRLRYHHNPGLFLPIEEVTDTMLHELSHNVWGPHDSNFHKLWDELRDEHETLLRKGYTGEGFLSEGHRLGGSNNHRAPPPHELRRLARVNAEKRRAQAGLASGSGQRLGGNPIHRGANVRNVIARQAIRRTTIDQGCGSMRDDAVILSDQVGSTIFKTKAEEDDANNLAISKALMELMEEEEMGKLNGTWKGDEKGGGEKPTAALPPPTVNAPTMPATPVTATDDWACQVCTCINPLQFLACDACGTERSQSVLVAAKAPPPMSQPIIKQERQERKPIPYPSRDRQAPSITGGVLDRGSTERTKSLGWTCSCGAFMEHRWWTCSACGRLKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM9</accession>
    <name>F9XBM9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_58820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852687.1">
        <property type="nucleotide sequence ID" value="XM_003852639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBM9"/>
    <dbReference type="GeneID" id="13393914"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58820"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="InParanoid" id="F9XBM9"/>
    <dbReference type="OMA" id="INMGLIC"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="31937" checksum="EC475CD1512B35FC" modified="2011-10-19" version="1">MQIPPLDVLLAWPSPNYENPKTRGEALLVLLIIFSILVVAAVIARFYSRIVVKKWYGLDDTMIALALLFTLGMNTSVILANRRYGWNRHIWDIQPGDIQNANIVAFSAKLLFVQAATFTRISLICFYYRLVRDSGIDWFIWVLHGGMFFVIGLGIAFTCIGIWLCSPVQAYWVFPPIAGSKCMDEGTTTLTIGIFNCLADLTTTLLPIPLVMRLKMPLKQRIEVCFLLGLGFVVTIAGIVRTYFIWKSLIDSWDTTWYSYPLWIAAAIEIDVAVICACAPALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ3</accession>
    <name>F9XCQ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_72813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851948.1">
        <property type="nucleotide sequence ID" value="XM_003851900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCQ3"/>
    <dbReference type="STRING" id="336722.F9XCQ3"/>
    <dbReference type="GeneID" id="13401278"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72813"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.123"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="InParanoid" id="F9XCQ3"/>
    <dbReference type="OMA" id="IVSTNCW"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="423" mass="46001" checksum="0FEABE752A35DAC4" modified="2011-10-19" version="1">MSKGKVLIAGASIAGPTAAYWFVKAGFTVTVIERFPRLRTAGQNIDIRTSGVTVMRRMGGMEAAVRDHLADFDGMSIVKEDGEPVIVIKASGNTEQQSLVSEFEIYRGDLAAILYDRTKDDVRYIFNEQITSMQDQDGGPITVEFLNGTPRETFDLVVACDGSTSRTRAIGLGCGVRDHVVSVNAWAAYFSISSDLLEGSRICEGHSVRGGRLYALSPGPDGTNRVLLQRCHSRSEQDATLSFRQAQEQGTEALKKFIYELYTGYGWKTQQIVDEMLDSKDFYASEILQVKVPSLSRGRFVLVGDAGYAAGPTGGGTSLALTGAYVLAGEIAASKGDIGAGLMAYEARMKPIIKDMQTIPPGVLTMMAPQTARGIWLRNLFLRFVSWGVKFSGLFAWLGGFWASAFGGDKYGIPEYEFSGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCZ3</accession>
    <name>F9XCZ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_93770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851421.1">
        <property type="nucleotide sequence ID" value="XM_003851373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCZ3"/>
    <dbReference type="GeneID" id="13401404"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93770"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="InParanoid" id="F9XCZ3"/>
    <dbReference type="OMA" id="AMCACPL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="34"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="471" mass="51680" checksum="0145899839D109F0" modified="2011-10-19" version="1">MDDFEKKNQNIVDWDGPTDEANPLNWSTGAKVANTSLVIILCFITPLASSMFAPGVPDVLREFRSTTSGIPELVVSIYILGFAFGPLLISPISEIYGRFQVYVVCNVMFIIFTIACAVSSSIAQLVVFRFFAGAFGVCPVTLGGATIADLLTQDKRGLGLSLFSMGPLLGPVIGPIAGAYLSDATTWRWTFWVIAIAYGVCTIVHFFLCRETYAPTLLARKTKRLQKETGNMELRSAKDSGLSNKVFITRSLVRPFKMFFFSPIVALMAIYAAFIYGILYLLYTTFTFVFTQDYNFTSANVGLTYLGSGIGMFLGLFLIGGASDRILKSKAEKHGGGLKPEYRLIPLVWTAWTCPVGLFIYGWTAEYHIQWAVPLFGTLLFGIGIIAALICIQQYLIDAYAQYAASAIAANTVLRSLVGGLLPLAGLTMYDKLGLGWGNSLIAFIALALTPIPLVFYIWGERLRNRTKVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD20</accession>
    <name>F9XD20_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_59831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851893.1">
        <property type="nucleotide sequence ID" value="XM_003851845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD20"/>
    <dbReference type="STRING" id="336722.F9XD20"/>
    <dbReference type="GeneID" id="13401416"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_59831"/>
    <dbReference type="eggNOG" id="ENOG502QVN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008537_1_0_1"/>
    <dbReference type="InParanoid" id="F9XD20"/>
    <dbReference type="OMA" id="GFDPSYH"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08650">
        <property type="entry name" value="FMT_core_HypX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="671" mass="74128" checksum="984C76C8672A0084" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDU8</accession>
    <name>F9XDU8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_73380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 115943 / IPO323</strain>
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        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
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        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
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        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribophorin_I"/>
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        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
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    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
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    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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            <begin position="463"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="492" mass="55447" checksum="1E066F051105022A" modified="2011-10-19" version="1">MRLLQWALLGFTAIVAADLNNTGESRNVLKSAFIPPKHFRNVNLVRNINLEKSYPRETVNVVIENIDQKAQSEYFIPFEQGLIGRIGGLEVKDKKQPDRTGFRTDVVGIDPFSTTEYYKITLPTPLPPNEQLTISITYVVLSALEPLPAQIQQNDKQYVQHTFSAYAPSAYTTKQQKTKLKLPTTDVPDAVKLPASLNAEGKEDPQKQGPTYTYGPYTNLEAGAVQEVSVRYEFTKPLTHGKLLERDIEVSHWGGNIATEERHWLTNRAATLKNHFSRVLFQQSSYYNPPSSALKEMKFPLIVGSADAYFIDDIGNVSTSRFRTNLREADLSLKPRYPIYGGWNYNFRVGWNGELENFLRKTKSGSDNFVLKVPFFEGPKQGEGMEYEKVVTRVILPEGATNVHFETTVPIVSDTISLTKTFMDTVGRTTLTVTAVNVVDELRDRDLIVTYDYPFAARFRKPLTIFAGVLVLFVASWVVGNLDVSIGKQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE98</accession>
    <name>F9XE98_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </dbReference>
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    </evidence>
    <sequence length="1039" mass="117119" checksum="B720AEC2B2A09C9C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEU1</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850853.1">
        <property type="nucleotide sequence ID" value="XM_003850805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEU1"/>
    <dbReference type="GeneID" id="13397591"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94725"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.673"/>
    <dbReference type="HOGENOM" id="CLU_576479_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEU1"/>
    <dbReference type="OrthoDB" id="10573918at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="51969" checksum="E71F308F0BABE92A" modified="2011-10-19" version="1">MKKIPGQSIPFSRAASKEPANTVTQISLVNLSNTCCNNIIFQPIMSGPAFVIPLHPDPQEFAKYIDAWGNITHRQQDATEVYTRAILPCLQQYMDGLKFQTTTYLEYLECGDTSEISLMQKLYESQTETETIEIDCETCEVRTTHSMAERIGRISGSAPANDLVIRAGLQEWTTEGAVKTKARMPVHDGLMAVTRLGTPMRAVNICQHKGPDVNSGHYVCYRRPALADLARESLIKRWPGSRGCDPKAQYINVLLAPITTADIIVLARLATAKFHADTVAAIEADLSLSDGKTAEALTRSPVRSALAGKDLTPEEFCSSFIGGGELAQAMDRLVDDGISCFENAKYGEHQAAWRAANDPNTMPPMAAPQRTQESEQIISSPVLSIRQWGSVPMSGKSARRDMTPCHIVDMLAGFQGEKEQRSDRKDKSIVRKGEEIIKAELAGGDDILEDDDFFEYLGDTFAREAEADGGSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF30</accession>
    <name>F9XF30_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_44869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850636.1">
        <property type="nucleotide sequence ID" value="XM_003850588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF30"/>
    <dbReference type="STRING" id="336722.F9XF30"/>
    <dbReference type="GeneID" id="13397374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44869"/>
    <dbReference type="eggNOG" id="ENOG502S6PD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038384_0_1_1"/>
    <dbReference type="InParanoid" id="F9XF30"/>
    <dbReference type="OMA" id="LYFGMWY"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="38282" checksum="CE7BEC718DCEC782" modified="2011-10-19" version="1">MIAHGNEVSNREQLQAEQRRQSVEANGDVERRAEGGSQDSDISETIGFEPEPPPLNYDLRSRKWAILFFWSMVLIDCIVAPVALYFTLWYMTDLSPNLVFTIVTAALGGVSIFEYFIRAWRLFRKNSTCRVIGAHRWYFDWFHFNFTLGWVAVMIELIVGTVQENPPIRLLAMPLPSMLFVFGTELLLVDLLRYYQIPSPCRMSSIPKGAQLRPAIYTMIEDVIAVDGSGGTPYREALNKRYEASHVFRAMLRRLGVFWAFGAEGCAVVTTVLVFTIQHEAAFVVGWSFPFAWAAVWAFVTIGYVKRKLREERTVWEEEILEKSGGVRVEDGGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF86</accession>
    <name>F9XF86_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850911.1">
        <property type="nucleotide sequence ID" value="XM_003850863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF86"/>
    <dbReference type="GeneID" id="13397649"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94813"/>
    <dbReference type="HOGENOM" id="CLU_767712_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF86"/>
    <dbReference type="OrthoDB" id="10457384at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40429" checksum="0FD36D4FE0E37C91" modified="2011-10-19" version="1">MSLTLTGVIRIMLLDHADTSGGGRKASIARVNFLAGRPSFHNPQEAVPDPRLDRFLLLPSFFSKQLNALRSLSSPAFTMPTIRLAPRRPKRKARNTSRTVSDKSKECLVFAILPQELIDHVMSFLPPANLKITVIATEQDDQNQASSSETLAVNGNTWKKLLATKRVSKRFNKSITNAIRLAQRNHRTILIMELHTSHPSEVEFNGTPQLGKSSVPDDFIAQFFWLHLRLPFMFDSLVPVSDGLVALVCHINMAISVDVLPNIAPRLAHLERPKPVFNVTYASERSMGPAFWIHSLAGLRYELKGLELVEQKEKIRGIVRDFDGKPASLMAMKELRGEIEEVLMDLPRRGNVDLNLSVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFJ8</accession>
    <name>F9XFJ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_110148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850665.1">
        <property type="nucleotide sequence ID" value="XM_003850617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFJ8"/>
    <dbReference type="FunCoup" id="F9XFJ8">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFJ8"/>
    <dbReference type="GeneID" id="13397936"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110148"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFJ8"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="368" mass="39551" checksum="24F11A3A4400E927" modified="2011-10-19" version="1">MASPQVHHLFHAPISDHSFSADHSTLAVTRDNAVELYASTGSGFKLADELRGHDKTVTGVDIAPNSGRIVTCSQDRNAYVWEPSATGQWKPTLVLLRINRAATCVRWSPSETKFAVGSGARIIAICYFEEENDWWVSKHLKKPLRSTVTSVAWHPNSVLLAAGSTDGHARVLSSFIKGNDERPEPSAWGERLPFNTVCGEYLNSTAGWVHSVAFSPSGNALAFTAHDSSITVVYPSAPEQPPQAVISIATQLLPFADMLWISESEIVCAGYDCEVYRFSGDVGGWKLTGSLEKSSAGAGGPAKEESALNMFRSMDLKGRSGGNVDDTKLRTVHQNTVNSVRAYEGGGSGQVTKISTAGVDGRVVVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFX1</accession>
    <name>F9XFX1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_20472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851130.1">
        <property type="nucleotide sequence ID" value="XM_003851082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFX1"/>
    <dbReference type="FunCoup" id="F9XFX1">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFX1"/>
    <dbReference type="GeneID" id="13397460"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20472"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="InParanoid" id="F9XFX1"/>
    <dbReference type="OMA" id="ARAHFHI"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="958"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="811"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="986" mass="107860" checksum="2B9D371C06792313" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG09</accession>
    <name>F9XG09_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_74100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850737.1">
        <property type="nucleotide sequence ID" value="XM_003850689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG09"/>
    <dbReference type="STRING" id="336722.F9XG09"/>
    <dbReference type="GeneID" id="13397847"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74100"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934502_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG09"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="32582" checksum="E3932E6A78B588AF" modified="2011-10-19" version="1">MLKAWLRELPSEMMPASLQKSLAVQLEKENPNYKNVGQPASQLLRDALSDLPPYNYYLLFAITCHLSLLLTNKEVNKMDLNNLAVCVGPCLNLERWLFNYLVGDWRHCWQGCYTEKDYLKIEEMVEAGLEPPHNSHHESYKTPEGEFRDDKSLTQSMWAATLGDDKSATNRSEWATTIGDSSENVSNSDSRAYSNGGGSVHTTSHDDSRSMTSGATVSGRAKQPQTYMPVGAKPHANGSLSSAAEQRHAKDDAVIGTTSNETTPKIGHARSRSDLPPAPVKSNGGGHDGEGAGLYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG24</accession>
    <name>F9XG24_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_74118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850742.1">
        <property type="nucleotide sequence ID" value="XM_003850694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG24"/>
    <dbReference type="GeneID" id="13397837"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74118"/>
    <dbReference type="eggNOG" id="KOG4179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032992_1_1_1"/>
    <dbReference type="InParanoid" id="F9XG24"/>
    <dbReference type="OMA" id="HTRIIME"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="36802" checksum="5DF267F09DA8B3D7" modified="2011-10-19" version="1">MGMPERHDKRDALTLAASLSDLEFEWEAGVDGSAIVEKAKPPIMDKELTLSNKTLGCWRAHMNALQRVVKENIQTALIMEDDVDWDVNIKQLALNLAHGTKYIEGSENRATRSPYGDDWELLWLGHCGMMKKPEPLARYYITDNDPTVVPPSHFHFPKRPLLDQPPLSANFTRLVFKPELGICAYAYAVTLEGARRLLHQETQSFTSASAADFALRRFCRVYKNWGTAANCIGAWPSLFTSYRAPGPTGKDSDRTTYAGPAWRDVGMSSHTVFSTRLNFEALLKPRGGSQRVIKSQWPDETLLREYTGELKLPQGRGIELVGHERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGE3</accession>
    <name>F9XGE3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_86704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851305.1">
        <property type="nucleotide sequence ID" value="XM_003851257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGE3"/>
    <dbReference type="STRING" id="336722.F9XGE3"/>
    <dbReference type="GeneID" id="13395313"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86704"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.34"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="InParanoid" id="F9XGE3"/>
    <dbReference type="OMA" id="KCATIAF"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
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    </dbReference>
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        <property type="entry name" value="SIRTUIN"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="305" mass="33670" checksum="BE01009968B9CE82" modified="2011-10-19" version="1">MSLGRDDAHDVKSFHSYLQESRSIIALVGAGLSASSGLAVFTGADGLWENQDPFSLATPEAFRSDAARVWRFYDRRRHEALQAQPNAAHFALAEASRQLPGFITMNQNIDGLSERADHPGSQLLALHGSLFEVQCTNTQSCEYWREDFTYSIVSMDSLSVEREHTPTQTQDTICPDPEISRPDCQLQGLPNCPRCNSILRPGVVWFGERLKDEVLLRIRHSFSQPEKIDLMLVIGTAAQVMPAAGYIDVARARGARLCFVNTDRNTGTGGNLQNGDWFFEGDAAVIVPILLEPVTSQGSRPHIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Lombard V."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="43302" checksum="7700880A0F092436" modified="2011-10-19" version="1">MHGTAPATRMGLLLVTSHQMSDLSPELGPPPTGQASFPTSRRSFCFAFIQVHTPTLVTTDAASLAAAVELQYYTPVHTTQRNSMRKSSRIMAQPAIIAPPRIVNKPKPVVGASCGHKCEDKAACSHKCCQVPLILAAWPSCDDFINSPPVLVCLLESLPVEDLFRLRHVNKTWKDTIETSTAFRQAAFLESEPTGETFHASIKEALLEPVSKYQQTDAQRFWGVKEYDVIDAPSRQVRINPFLFATSPCWYRNDLRYPEPENFSPDGAPLWTSLVPKFDAIRDVDDKSSCMEMFLTQPPVKEVIVDIHQRATHIAYGWVEEHTVPLLLSTDGDGFRYRDLHKWLNSFRGLAGFEKVEIIDGPGIIHIPRCEAIGEHVMPRAQRKKR</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Bristow J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
    <dbReference type="InParanoid" id="F9XGZ4"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Peroxin-3"/>
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        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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            <end position="64"/>
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    </feature>
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        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65301" checksum="EDC11A0A3AF48130" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH39</accession>
    <name>F9XH39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_75163</name>
    </gene>
    <organism evidence="7 8">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850234.1">
        <property type="nucleotide sequence ID" value="XM_003850186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH39"/>
    <dbReference type="FunCoup" id="F9XH39">
        <property type="interactions" value="953"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH39"/>
    <dbReference type="GeneID" id="13394587"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75163"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.687"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="InParanoid" id="F9XH39"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="189" mass="21432" checksum="CF731A86D835FFDD" modified="2011-10-19" version="1">MPAYHSVFLDEPNQQLIGNFALLPLRTRTRGPAQQLPALTSSTELDIDPSNESYDPLDEVLSLFRANTFFRNFEIKGPADRVLIYGILYVTEALNKIRPNMGRKEAEKAVMSSALDTNFAVPGDAGFPLNQMFEAPRDRNEAEVLRQYVMQMRQELAARLLNRVYADGTGVPSKWWLSFSKRKFMGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHF8</accession>
    <name>F9XHF8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transport PHO88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_46537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849996.1">
        <property type="nucleotide sequence ID" value="XM_003849948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHF8"/>
    <dbReference type="FunCoup" id="F9XHF8">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHF8"/>
    <dbReference type="GeneID" id="13395003"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46537"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.288"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHF8"/>
    <dbReference type="OMA" id="NMDYDKG"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19468" checksum="C34FEA23CFE3037D" modified="2011-10-19" version="1">MMQASKKIPFEDPMVLMGVRGLYIFSNVLILGIYLYVKAQIDRKRDMTVLKYVEPAPMGSTEEPKAVTTTVHAYDQQQLKALFKSQLMGVGMMCVMHLYFKYTNPLLIQSIIPLKGAFEGNLVKVHLLGKPASGDLKRPWKAAGGMMGAMQGAGEIKTDKKSIEAAEKAGRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHG3</accession>
    <name>F9XHG3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849999.1">
        <property type="nucleotide sequence ID" value="XM_003849951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHG3"/>
    <dbReference type="STRING" id="336722.F9XHG3"/>
    <dbReference type="GeneID" id="13395001"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95098"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="InParanoid" id="F9XHG3"/>
    <dbReference type="OMA" id="CYDKWQA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26337" checksum="E9F1B11A527E1080" modified="2011-10-19" version="1">MFQRFDVNTKGTDLAQDLAPWSQSFQAERNSRQDSKVEVRPLVLDLQSFDSVRAAAKEVIAQTEHIDVLVNNAGVMAPPYSKTIDGFESTFQTNHLSHFLFTNLIMEKLMSAPEPRVVVVSSDGYRLGHVRYNDYNFHDGESYNPCLTRRDIEVGAPQAWAGLDVIGEDQGIATHVFAAFSPEVKEFNGGYLEKLQQVPFPDESIYPWAIGELEQRRCWKLSEELVGRVFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI18</accession>
    <name>F9XI18_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein sec72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_74369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850530.1">
        <property type="nucleotide sequence ID" value="XM_003850482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI18"/>
    <dbReference type="STRING" id="336722.F9XI18"/>
    <dbReference type="GeneID" id="13395183"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74369"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090376_2_0_1"/>
    <dbReference type="InParanoid" id="F9XI18"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22966" checksum="A6BCEBE661DB457E" modified="2011-10-19" version="1">MEAPVELSDTFKLLPLVLDPNTKAVSSSDQSLANELLELNQIHRGMLAVENPSQTPPPPAPVNPKRSAQITKLKEEGNKLYKKASYTEALQIYDLAIKMAAERPPWEASGLVREELSTLHGNRAQTLMAQHSWAEAAVDAEIAVEMKKVGNVKAWWRRGQCLKEMGRLEEATEWVKQGLDFERAGPDKQNIGELETLQREIANATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI99</accession>
    <name>F9XI99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_74910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850083.1">
        <property type="nucleotide sequence ID" value="XM_003850035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI99"/>
    <dbReference type="FunCoup" id="F9XI99">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XI99"/>
    <dbReference type="GeneID" id="13394749"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74910"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019358_1_0_1"/>
    <dbReference type="InParanoid" id="F9XI99"/>
    <dbReference type="OMA" id="TMTIFFN"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="244"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="403" mass="44905" checksum="CEA5B8059BCB3DD9" modified="2011-10-19" version="1">MSRMTVRTFLVAAKRQLQNSIRDKTFTSFVIGNESADLDSITCALVYGYIQSSNSEAKKTGRLVVPVTNIPASDLPLRPELTALLRHAGILPSELITLDDLGTDPLPQDKTEWTLVDHNAMQGKLGERYSSRVVGVIDHHDDEKKVSKDAEPRVIEKTGSCSSHVTNYLRETWQSLGSMVSQSHVGWGQEDVAKLALGAILIDTINMKAEHKITDHDRKAVRYLEAKINISPKLGKDYDRDRFFNEINDAKSNIDDLSLEDVLRKDYKEWKEGDLTLGIASVVQSVKYLQGKEKDFAAAVKQFAQKKSLSIFAIMTAYQDSSNQFAREILLIASNEKAKGAVERFVENGGGELQLQDADDAADMQEDTTILYQHHWAQKNLDASRKRVAPLLREAMAGKGANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIF4</accession>
    <name>F9XIF4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849927.1">
        <property type="nucleotide sequence ID" value="XM_003849879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIF4"/>
    <dbReference type="GeneID" id="13402721"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94973"/>
    <dbReference type="HOGENOM" id="CLU_548853_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIF4"/>
    <dbReference type="OrthoDB" id="3650127at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="497" mass="56071" checksum="0A405664BF3EA904" modified="2011-10-19" version="1">MSGEGVSSILPQGPTTTALLTLRERTDDRHPRQSRIRSQTNLFIDRKWYSSQISDPSGSDKETSSLHSIEANFSNHRIILRKHSILDHLDSMFPSLGQDSSSTDDHTRYLQRHHCTTTPDYLPAIADPVLLGAWLFVKLKPWGVNHCWPDDRWLDRPIRTFVRPEVEVLQLREIVYQALRKAGSSPNIINDPFFPDAIIMFTFYMSMTDGWASGLQKVEFLVLLASARMQTAASGASEAYRTTVAVDAFRTVLSRYVKSEYVLALEGMFTMAQTIMRNSAMDTIEAEFDDCGQPVWKRVYLLDSAGWYQCYKEPLLEIKCLAESIPRNIERVHEVVEDGPFLAFEDVELPASLLLNSHTISRAFFSTMLRVASTIGASLATLAPSSYLRRLIDLIDFIENLPDGLVERVKLGVCLAFDRPALVLGPAWSWAPHVRDTASSNHFAIPHDRRIGITSVEYDGHADARLDKIHVLEGSVLEVENTTWQNVVLRDTHQVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIK8</accession>
    <name>F9XIK8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_46366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850295.1">
        <property type="nucleotide sequence ID" value="XM_003850247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIK8"/>
    <dbReference type="FunCoup" id="F9XIK8">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIK8"/>
    <dbReference type="GeneID" id="13394723"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46366"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.545"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIK8"/>
    <dbReference type="OMA" id="EGYIFHA"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="581" mass="64472" checksum="65B38605F23128C1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIX3</accession>
    <name>F9XIX3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_101240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849430.1">
        <property type="nucleotide sequence ID" value="XM_003849382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIX3"/>
    <dbReference type="FunCoup" id="F9XIX3">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIX3"/>
    <dbReference type="GeneID" id="13402471"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101240"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.379"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="F9XIX3"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="29626" checksum="8CAC621E1D781A46" modified="2011-10-19" version="1">MSGKDREQVFPTRQSLGIMKSKLKGAQTGHDLLKRKSEALTKRFREITRRIDEAKRKMGRVMQIAAFSLAEVTYAVGNNSIGYQITESARNAKFRVRTKQENISGVFLPAFESFQKEGASEFGMTGLGKGGQQVQKCRETYTRAVETLVELASLQTAFVILDEVIKMVNRRVNAIEHVIIPRTENTIKYINTELDELDREEFVRLKKVKGFKEKAAAEEEAERKKKAEREKEKENDEGAANGQQSGESKNILGEDGDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIY0</accession>
    <name>F9XIY0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_47143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849433.1">
        <property type="nucleotide sequence ID" value="XM_003849385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIY0"/>
    <dbReference type="GeneID" id="13402467"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47143"/>
    <dbReference type="eggNOG" id="ENOG502SKAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_1"/>
    <dbReference type="InParanoid" id="F9XIY0"/>
    <dbReference type="OMA" id="WNSNMYL"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="368" mass="41175" checksum="CA6F45E300E9420E" modified="2011-10-19" version="1">MLSCVARFARTTVKSSKGSTCVAQSRFKSHLAPPWLLDDYIPRYQLLTSVQESKKRASAYAHLRECNLCPRLCGVNRYEKRGTCLIGMSDVSVNTIAPHFGEEPCVQGHHGSGSVFFSGCNLRCVFCQNHDIAHQQNGFDLTPEQLGDWYVKLQDVGNVHNINLVTPEHVVPQVALSILHAKDRGLKVPVIYNTSSFDSLESIRLMDGLVDIYLADFKVWNPATSKRLLKADNYADVAKESIQAMHAQVGDLCFTSDGIAKKGVLVRHLVMPGLEEEGKHIVRWLAENVSKDLYIHVMEQYHPRAHVGKDRRQTRSANAIVENQIKRYQDINRAVKPEEVDGVKSVAVKCGLRVLEADEAAESSAWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIY7</accession>
    <name>F9XIY7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_47106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849280.1">
        <property type="nucleotide sequence ID" value="XM_003849232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIY7"/>
    <dbReference type="STRING" id="336722.F9XIY7"/>
    <dbReference type="GeneID" id="13402631"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47106"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.54"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIY7"/>
    <dbReference type="OMA" id="CIITTRI"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37599" checksum="3EA18DA1C1FF06AD" modified="2011-10-19" version="1">MTLHTPTPNPSPFVRFTRRIYHPLHFQKGYNFTLWFIFSAALLGFHLARAQYMNVSASYLPQAGPGEAYYFRQYYYRIGISIHLIAIIPAGFLVLFQFIPYIRHTFRLFHRINGYIILLLLLISNVGALLIVRRAFGGTLATQSATGVLALATTLGSVLAYINIKSLQIDQHRAWMLRTWFYAGSIITTRLIMIIAVQIISSIGSYYTAMSCAQIAGTRDDGDVSAYPACVSDPGGYTAVHADFSSTAGIEEIAAGFELTFGMALWMAMVMHAVGVEVYLRLTTAEGERLREVSYERQVEKGMKRPGRAGLTADRLGDVEGWVPRGKGEVGEGGMKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJK7</accession>
    <name>F9XJK7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">GDPD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_110829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849471.1">
        <property type="nucleotide sequence ID" value="XM_003849423.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XJK7"/>
    <dbReference type="GeneID" id="13402266"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110829"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005444_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJK7"/>
    <dbReference type="OMA" id="WTPMEHA"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="126"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="930"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144488" checksum="EC9D1A11E321DF48" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJS3</accession>
    <name>F9XJS3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="F9XJS3">
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.19"/>
    <dbReference type="eggNOG" id="KOG1300">
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    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
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    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016192">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="80649" checksum="06DFDC5F8B22FA08" modified="2011-10-19" version="1"> </sequence>
</entry>
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    <accession>F9XLA5</accession>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76111"/>
    <dbReference type="eggNOG" id="KOG0101">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70925" checksum="1C56124C794B81B0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLP5</accession>
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        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13398475"/>
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    <dbReference type="eggNOG" id="KOG0234">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_3_1_1"/>
    <dbReference type="InParanoid" id="F9XLP5"/>
    <dbReference type="OMA" id="HAYRYNE"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM26</accession>
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    <organism evidence="4 5">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848436.1">
        <property type="nucleotide sequence ID" value="XM_003848388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM26"/>
    <dbReference type="GeneID" id="13396437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101642"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.407"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM26"/>
    <dbReference type="OMA" id="WNYLDAP"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52137" checksum="1FC5C6C71A718EFB" modified="2011-10-19" version="1">MAFGSSKKTDTEAGSVSAPVSDGTPSATVSETNSLKDVERPQTASSSKDVAAVPTDGQVPSDSSKLRTFLGILKRFIGVSDMAAVRFSLPAQLLEPIPNLEYWHYLDRPETFAAIGDSDDPLERMLHCLRFWFTKDLKYVKGKPCKPYNSALGEFFRCSWEVQKEEAMKTVGTAQQPVKVHYLTEQTSHHPPVSAFVYDCPEKGVSAVGYDQLSAKFTGTSVKVTPGAHNQGIFITLRQRGNEEYRLTHPAAFLGGFLRGNLYITVADTCFVTCEKTGLKTILHYLEEGYFGKTQNKVEGIVYKPSSILDDKVTRLKDVPSKEIIGRIEGVWTEKIWFVPGSADFKKSKESERILLMDVSPLLPIPKKCPPENQQLPNESRKFWGGVTDAIVAKQYGQATQRKTELEERQRERAAERAKEGKEWSPRFFTTVTEKDGRPRVSEVGKKAMEGLQAGDYTLEKPAEYGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM97</accession>
    <name>F9XM97_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_77116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848509.1">
        <property type="nucleotide sequence ID" value="XM_003848461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM97"/>
    <dbReference type="STRING" id="336722.F9XM97"/>
    <dbReference type="GeneID" id="13396198"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77116"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.490"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109501_1_0_1"/>
    <dbReference type="InParanoid" id="F9XM97"/>
    <dbReference type="OMA" id="MSMHLPL"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="163" mass="17876" checksum="11E9035BCB56019E" modified="2011-10-19" version="1" fragment="single">MLLKSGRPTLCTRCLQSAQQIRHASLIRRPKRPYTFTQLITLSDGSTFTHRTTSPQPVYRSAKDTKNSLLWNPSSAKLQNVEEDEAGRLRNFRKRFGRGFDAEAVEAEEGDEKAGGSSAVKEESLMDMITAMPKQQEAKKGKVAAAATPEPAAKSGKPKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMS9</accession>
    <name>F9XMS9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_63574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848667.1">
        <property type="nucleotide sequence ID" value="XM_003848619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMS9"/>
    <dbReference type="FunCoup" id="F9XMS9">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMS9"/>
    <dbReference type="GeneID" id="13396308"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63574"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.150"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="F9XMS9"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043530">
        <property type="term" value="F:adenosine 5'-monophosphoramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="14922" checksum="B47441E0F300A997" modified="2011-10-19" version="1">MSTAACIFCKIIKGEIPSMKLFESEKTLAFLDINPLAYGHALVIPKHHGAKLTDIPDADLSELLPVAKKIASAQGSENYNILQNNGRLAHQEVDHVHFHVIPKPDETQGLGIGWPMLKGDMDRLKKLAEEIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNB0</accession>
    <name>F9XNB0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848407.1">
        <property type="nucleotide sequence ID" value="XM_003848359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNB0"/>
    <dbReference type="GeneID" id="13396421"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96726"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.353"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="InParanoid" id="F9XNB0"/>
    <dbReference type="OMA" id="QSDYPQK"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37043" checksum="8D9C615A888D5258" modified="2011-10-19" version="1">MHKDKFLSLAYVWIGGLLPLLKPEKKDLTGKTVVVTGGNSGVGYGLALQLAEMGASVYIACRSEVRAAKARNSMLESCPDAKIGIEILDTASFESVKAFAANWNHGRIDILAHNAGITLPPHGKEFTEDGYEYLYQVNILSSFLLTGLLDSEGKLAEDLRVLFTSSVAAYESSIPDDFSVAKTQLKRDPQIHGDDRLADRYSHTKLLQVVFARALQVQFERDPGNKRLAFSWEPGLTRTKIFEDVPNARWDLRFWLVSNVMPYVGIDERQGSATGVHLATSDSPDVLGNKGRMFNRMKARWLEVDGYSQEKLERVWTRFAADADISWPWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNI2</accession>
    <name>F9XNI2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin protein ligase</fullName>
            <ecNumber evidence="4">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BPL</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_111438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="4"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847900.1">
        <property type="nucleotide sequence ID" value="XM_003847852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNI2"/>
    <dbReference type="STRING" id="336722.F9XNI2"/>
    <dbReference type="GeneID" id="13401766"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111438"/>
    <dbReference type="eggNOG" id="ENOG502SI15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057558_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNI2"/>
    <dbReference type="OMA" id="KRWLYFQ"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391799" evidence="2">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin-protein ligase N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="304" mass="32945" checksum="AC8B99600902C381" modified="2011-10-19" version="1">MQSFIFLLLTLTSAQVMAKRQRPQAIVYRGPAASEGLPESVAYLLQSSPRNFEVRYAGPNEDLSISAETLRDISLYAQPGGPDVDEAWDELEPFATPIRDFVAGGGRYLGFCLGAYLAGHSPGLNLVPKNTDVGSEIEQNDAQITDDKDSIIQIDWTYSSGEKAGQTVNNTWIYFQEGAVMENFKPDNTTFILGRYSKNGDVAASVSQYGKGWVGLIGPHPEADQTWFDEYDLDHPDGLRYDIGYDLIEATMNGGPQKSNTSQTQGASPTQDQPPAQYTSGASRSTVTLGSAAILPALMLSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNZ7</accession>
    <name>F9XNZ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_50857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847984.1">
        <property type="nucleotide sequence ID" value="XM_003847936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNZ7"/>
    <dbReference type="STRING" id="336722.F9XNZ7"/>
    <dbReference type="GeneID" id="13396032"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50857"/>
    <dbReference type="eggNOG" id="ENOG502QPN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019746_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNZ7"/>
    <dbReference type="OMA" id="VVPWMMF"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65948" checksum="09769D11FA315428" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPA1</accession>
    <name>F9XPA1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_111565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848056.1">
        <property type="nucleotide sequence ID" value="XM_003848008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPA1"/>
    <dbReference type="FunCoup" id="F9XPA1">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPA1"/>
    <dbReference type="GeneID" id="13402107"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111565"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032848_1_1_1"/>
    <dbReference type="InParanoid" id="F9XPA1"/>
    <dbReference type="OMA" id="GFKRPFN"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="275" mass="29320" checksum="1B6E087D8416513A" modified="2011-10-19" version="1">MSVDLHPPELGFRRPFTHEVSQVLRLHNPNSEPVAFKVKTTAPKQYCVRPNSGRIEPNSDVEVQVLLQAMKEDPPADARCRDKFLVQSVAIGAAAAESSANVAQIWSNIEQTAKSSIQEKKIRVSFLPADGSNPASNGLAASHHEDESPPSYSSPAPPALGALSTPQKQTTDSSARSPEAPSTAKSTLVNTVANVTGYSQKELEQQLEEAKTTISRLQQQATDGLRQRKTGGSGSTDTAKGIPASLQTGSPPGGVSVQIVALLCFLSFLIAYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM4</accession>
    <name>F9XPM4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_106442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847828.1">
        <property type="nucleotide sequence ID" value="XM_003847780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM4"/>
    <dbReference type="STRING" id="336722.F9XPM4"/>
    <dbReference type="GeneID" id="13400815"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106442"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="InParanoid" id="F9XPM4"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="248"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP82804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="413" mass="45807" checksum="61A08CDB84E16B4E" modified="2011-10-19" version="1" fragment="single">MADSAEIPERPKDAAPAAEGEGDDKGPSKSALKKAAKEKEKAEKRARLAAEEAARKKEADANDISKEDYGELPLVRTSTGAKHEKLADLAEKHDGQAIEEGKGPAVIFRATVNNARNQGAKLSFLQFSQGPNTIQAVVAQSEKLSKQMVKFAGGIPTESEVVVHGTLQKPFEPVKSTTIQNLEVHITKLYILCKADSQLPLQVADAEGRIPAEGEENAVQDGKPIVSLNTRLNNRTIDLKANLNHAIFTIKYGVQKLFTEFLDERGFLGMNTPRMLGAATEGGSSVFEIKYFNDKAYLAQSPQLYKQMMIASRFERVMEIGPIFRAENSNTARHLTEFTGLDLEMAFEEDYHEVVTLLEELMLYIFNGLRTKYKKQTDLVRTVYQVEEFKLPPPGKVPRLHFKEGIAMLREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPT1</accession>
    <name>F9XPT1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MGSUL7</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_101851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847540.1">
        <property type="nucleotide sequence ID" value="XM_003847492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPT1"/>
    <dbReference type="FunCoup" id="F9XPT1">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPT1"/>
    <dbReference type="GeneID" id="13401209"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101851"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.91"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPT1"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <end position="243"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="301" mass="34195" checksum="1BBED3BB50C48AD5" modified="2011-10-19" version="1">MARNRSPSSSDEDNTESGYASGSSTASLSNEVYFSRAHLKFINRQLSLLEPQEVLKWCMTSLPRLYQTSAFGLTGLAIMDMISKLDYAIAPPIEMIFLDTLYHFSQTLELVDRVKSKYPNLTIHTYKPEGCDTTEDFEAKHGQKLWETNEELYDYVAKVEPAQRAYRDLNVQAVLTGRRRTQGGKRGDLDIIEVDDAGLLKVNPLANWNFKDVQAYIKENNVPTNDLLDQGYRSVGDWHSTQPVAEGEDERAGRWKGRAKTECGIHNKRSRYAVFLQEQEEKRQQELSDAINAGLQIETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ79</accession>
    <name>F9XQ79_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_88465</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="F9XQ79"/>
    <dbReference type="OMA" id="LERYQHH"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990143">
        <property type="term" value="C:CoA-synthesizing protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39501" checksum="8F693451E7926B58" modified="2011-10-19" version="1">MEYFANNPKPGSLDRHSQLSRDFIEQHSKAGRRVALVTSGGTTVPLENQTVRFIDNFSAGTRGATSAEYFLENDYAVIFLHRQFSLLPYSRHYSHSTNCFLDYMTGTEDGPVVVQNEYQQQMAGVLRRYRKAKKGNLLLLLPFTTVNDYLWHLRELAILMQPLQANALFYLAAAVSDFFVPADRMVEHKIQSSEDFHTKKQPKGNGEPEERTPAAHMEAGSLIIDLDPVPKFLKLLVDEWSPHAMIVSFKLETDPALLASKARGALEKYSHHLVIGNLLNTRKYEVLFVSKAEGEKWVRVSEENRAKSTARIAEGGKEDFSDSSVEIESLIVPQVKELHTSMIQAGKTRS</sequence>
</entry>
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    <accession>F9XQN4</accession>
    <name>F9XQN4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97571</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847433.1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97571"/>
    <dbReference type="HOGENOM" id="CLU_383199_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQN4"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="722" mass="81428" checksum="3FA8EDD2295ED098" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR23</accession>
    <name>F9XR23_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin/FtsZ 2-layer sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_97626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847311.1">
        <property type="nucleotide sequence ID" value="XM_003847263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR23"/>
    <dbReference type="STRING" id="336722.F9XR23"/>
    <dbReference type="GeneID" id="13400143"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97626"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.16"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_6_3_1"/>
    <dbReference type="InParanoid" id="F9XR23"/>
    <dbReference type="OMA" id="MCMISNS"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="15482" checksum="89A90BA53D591A04" modified="2011-10-19" version="1">MEYDDRQRRRPQGGSPGRCCPKTKCTIPFIDWCPTGFKLGIYYQPPQNVPKGDFTKKSRQGNRAVCMLSNTNAIAEARSALSHKFDLMLCDFVHWYVGKGMEEGGFSEAREDLAALERDYGEVAADSAEDDEGGEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR82</accession>
    <name>F9XR82_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_97741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847236.1">
        <property type="nucleotide sequence ID" value="XM_003847188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR82"/>
    <dbReference type="STRING" id="336722.F9XR82"/>
    <dbReference type="GeneID" id="13399934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97741"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693009_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR82"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="398" mass="43847" checksum="8ED6C5EFE3D67EA2" modified="2011-10-19" version="1">MPLCPRFYREMQTSRLQVEEQFGFSAMPFLGRTAVTIQGQSPAVDVDDQHKLIMTHCAASPTATAKALPLVQLFSWADFFSHIDPSCDTNLHPLLSWLEQEWPAFDARNYAENDDCDDNVELELWQRGDEEDEEEDDNEALNGDADLEEDNADVDAEGDAPPVMEKTKAAAKRNAAAQASEDRGGGHDKELIAMEATKEPPTRTVHEFAASGAQPLSTPLRYLTTTTSIGLPGGPAREAARMISVLDALKDTPDIFGVTHMGSEATFSAPEARHAKMAIYKRPSEHTTLDSRPSCRCKAAASGKAKEEAATDAMKWPLRNFGKVVGDCPYDKDYLSRTTKAKCNPQSEVVSIHPFSYRCSAQQLLKLMIAQEVGPILAACGLQVIVLYSRHHLRNRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR92</accession>
    <name>F9XR92_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847242.1">
        <property type="nucleotide sequence ID" value="XM_003847194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR92"/>
    <dbReference type="GeneID" id="13399895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97751"/>
    <dbReference type="HOGENOM" id="CLU_1215619_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR92"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="25220" checksum="2593C51D3589BE2B" modified="2011-10-19" version="1">MEANHFSGLGRKVAARQSIQGCDDEEEAQVQEERCIFKRSDEEGKSTTAQNSRLLPVPKASETSQAMKLSRTPKRSEPSLTDSATMRIRSATKKANCDGELEVRDAGDFENAVSGQGNGPRTRQEPGEVSYDRSPKRAGLFEVEPPGILSWREQFYEHTSHIPFREDYLISRKSLLNRPAVSSPDSVFSPSQDGRRVDALLRKDTGYDASAEDRPAAPVSVGLLIIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRW2</accession>
    <name>F9XRW2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847009.1">
        <property type="nucleotide sequence ID" value="XM_003846961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRW2"/>
    <dbReference type="GeneID" id="13399254"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97956"/>
    <dbReference type="HOGENOM" id="CLU_1310980_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRW2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="210" mass="22078" checksum="5B609B1B4258825A" modified="2011-10-19" version="1">MAASDSAAAPAVSCTAAASLLFFIVALILACFAGTSIATFFTSVVGGIIVAAVWLVLFFVVDHVILYQIGEFYQKGRTCVMYGGLSAGRELVMPKAMTTQATVFWPTVVGSRVSDLGLRQQIVCVVHACGYRVMKMQASHPSVRARQTTSRRTVAAAVLSIVLIIAVAGIFISPWYASAIAAFAVADLVRSRVASTIAASAFEDALTEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW37</accession>
    <name>F9WW37_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_102085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857681.1">
        <property type="nucleotide sequence ID" value="XM_003857633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW37"/>
    <dbReference type="GeneID" id="13403252"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102085"/>
    <dbReference type="HOGENOM" id="CLU_2489571_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW37"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="87" mass="9995" checksum="5330AE1B2FD4723C" modified="2011-10-19" version="1" fragment="single">MVNDLMYRCANHALWIYLFRLGPPLGGSCDGVLILAGRTDKRAGFRVMDGCEEHFFVPCARPDRRDCALHPLFIRSVNHDIDIYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWJ5</accession>
    <name>F9WWJ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_66294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-mannitol + NADP(+) = D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16767"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856354.1">
        <property type="nucleotide sequence ID" value="XM_003856306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWJ5"/>
    <dbReference type="GeneID" id="13402888"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66294"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="F9WWJ5"/>
    <dbReference type="OMA" id="GKAMTKY"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="328" mass="34441" checksum="5F4FFB7032DE12BE" modified="2011-10-19" version="1">MRAISTTASSKLQHSQSITNPNIKVTHFEDGKRVQENVEVDVGAAAPIVAADVPYIASGLQAKVREALPTTIKNFTLAGKTAIVSGGARGLGLNMAQALAEAGVDNIALIDVNEEAGVKAAQDLQDQTGVKVIFVKVDLRNDEDIQAAVTQVAQTFGGINVLVNSAGIAESNIPAELYDGQAFRKTIDVNLIGCFVLNQAVAREMIKGGEGGSIVNIASMSGTIVNYPQPQCAYNASKAAVIMLTKCLAAEWAPHAIRVNTISPGYMDTALNRVPALDAQKKIWVAQTPQKRLGAVSDLNGLAVYLASDASAYMTGSDSIIDGGYTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWY5</accession>
    <name>F9WWY5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_67079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857063.1">
        <property type="nucleotide sequence ID" value="XM_003857015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWY5"/>
    <dbReference type="FunCoup" id="F9WWY5">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWY5"/>
    <dbReference type="GeneID" id="13395403"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67079"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1633"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="InParanoid" id="F9WWY5"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="31133" checksum="82AEB521AA4689BA" modified="2011-10-19" version="1">MDDFASDTDSDYTSYWRDWFISSRGNEYFCEIDEDYLTDRFNLTGLNTEVQYYQYALDLVTDVFDMEVDDDMREQIEKSARHLYGLVHARYVVTTRGLAKMMEKYKQGVFGKCPRVICESQHLLPMGQHDVPNTSHVKLYCAKCEDIYNPKSSRHNSIDGAYFGTSFHNILFQVYPALQPQKTQRRYEPRIYGFRVHASAALMRWQEERREEMKDRLRARAIETGFEDEDEGEEEIESEEDEVDEEQDGIDDMFEGNARMQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX01</accession>
    <name>F9WX01_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apoptosis regulator Bcl-2 family BH4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_67102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856625.1">
        <property type="nucleotide sequence ID" value="XM_003856577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX01"/>
    <dbReference type="STRING" id="336722.F9WX01"/>
    <dbReference type="GeneID" id="13395410"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67102"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1655"/>
    <dbReference type="eggNOG" id="ENOG502QVA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036627_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX01"/>
    <dbReference type="OMA" id="NHWNAWK"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48312" checksum="90F5AAE858F73749" modified="2011-10-19" version="1">MFQFRLPQLPSWSLPGSGIKVPKAEVHDIEERPEKRARTLKHLLKANHINHSIIYNQLRFHNHTPHILGSAYILGADADELNHLYEAESKHLEPWVDSPGEISRDDWREFLGKKEYQRAFIDFFEDQLVRHGYDWRSLLDEYLLSGDEPLINNLIAGLAHPLIHLGYGYELSSRTVAIEALGLAACFYNDWHVYLDDPKYTKPARNPTDSLFTILDRVASDPKFDNLADHQGPDNIENILGNEELAAAALEYWNSWDIKKPTEQFAESQKLAVALVVAAQSSKNEKGYDFFGVHLLTSSHAVRTLLPLIPSKHHVPLVRQWWLFTILVYIAQLRPRINIDKIKLVELEGRDWKFVKEKALKSEYSTDAHFVKALRCMHEASKTWGDANQFYLKSAVKMAEEFHGWGGFGAMVLDERLTHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX24</accession>
    <name>F9WX24_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856995.1">
        <property type="nucleotide sequence ID" value="XM_003856947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX24"/>
    <dbReference type="STRING" id="336722.F9WX24"/>
    <dbReference type="GeneID" id="13398103"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90064"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1807"/>
    <dbReference type="eggNOG" id="ENOG502TB88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649253_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX24"/>
    <dbReference type="OrthoDB" id="3884299at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="54476" checksum="8E1C951A02DC3F56" modified="2011-10-19" version="1">MFVNRKSDLEYLRLANPVTELSSPNNPNNTQQSHTYRQHLCHLEMAHEQTAIVASDARAVSKLYAQIRSNQRAMRFQAPLPNMPTQFRTIHPRDVTKAHPMQRILPSFLEGNSPSIADAIWLYFRFVSYALPIFHTLMHREPELTPRDDASKPSIWLYPEPLLDLSKEQEDCTWTFLGRMGSQVTWVVDKDATDKTLGWTLKQCNRPLLDAGLLGYGSIITTTPGMIQMVEDAFQSDRIEDHKRHSFNLAFLWLHELSHAIRNAVVPWLKGSKDDAMFLGPDASTSEDGFEVQSRVFGGRLFGSYERKLNAEMVLQEWPDVGTIRQYRDLGYMLLTRGSAESLTREWTIRWKVEPSYWERMFEDSFWTKTLVVGRSDALWPDKSIGVLCKFVSRALTKEEEEKLERKMELEGYERRRNDLLVRKGLELELEAMYESDSDGTAETDSDGMGDVEMGDLGDVRTGESEDAEMTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXH6</accession>
    <name>F9WXH6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_78092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855891.1">
        <property type="nucleotide sequence ID" value="XM_003855843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXH6"/>
    <dbReference type="GeneID" id="13403830"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78092"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.134"/>
    <dbReference type="HOGENOM" id="CLU_2387873_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXH6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="94" mass="10228" checksum="F06D8BE12CC97C07" modified="2011-10-19" version="1">MSVTNLLCNKLGFPCHHIAISTGNSTTDGQFLVGVEAWAKTQELLVYLSCGTFINVWRCARGSHGTRNVDTTPVCLVDVSAVRERIGGIRRHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXM5</accession>
    <name>F9WXM5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_83446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857653.1">
        <property type="nucleotide sequence ID" value="XM_003857605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXM5"/>
    <dbReference type="STRING" id="336722.F9WXM5"/>
    <dbReference type="GeneID" id="13403939"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83446"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_19_1"/>
    <dbReference type="InParanoid" id="F9WXM5"/>
    <dbReference type="OMA" id="HIETEIM"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="146" mass="15623" checksum="45D01C4AB7847417" modified="2011-10-19" version="1">MSSQLRSGPLAPGIAFITGGARGLGNAIAVSYAREGAKGIALVDILDDKALEAGKAEVEKYGTKCITIRADVTKEADVERAIAETVEAFGRIDYTANFAGILGSLNMSWDTSIEDFSRVINVNLIGVWICTKLQLKQMIKQDSIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY18</accession>
    <name>F9WY18_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_35012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856263.1">
        <property type="nucleotide sequence ID" value="XM_003856215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY18"/>
    <dbReference type="GeneID" id="13402966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35012"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_1_0_1"/>
    <dbReference type="InParanoid" id="F9WY18"/>
    <dbReference type="OMA" id="HTFKSIY"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22588" checksum="A81A4512D52841FE" modified="2011-10-19" version="1">MAAPKDSEKAPDAHRELPSKETVQKAGEHMIKDETGNEIAFKTLYADKPADERQLIVFVRHFFCARDLPLDKLAAAKTTLTIIGCGEPVCIEDWRKRTGCPYKIYADPKRQLYSTLDMLAGFKAMPDEMPEYHSKSLFGVIKTSSWNALTSGPKKMLSGGPAYQQGGDWLFQNGEVKWVHRMRNSADHAETSELKEVLGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYC9</accession>
    <name>F9WYC9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857053.1">
        <property type="nucleotide sequence ID" value="XM_003857005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYC9"/>
    <dbReference type="STRING" id="336722.F9WYC9"/>
    <dbReference type="GeneID" id="13398840"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107593"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1658"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109497_1_0_1"/>
    <dbReference type="InParanoid" id="F9WYC9"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17970" checksum="416F7A6CB8F021EB" modified="2011-10-19" version="1">MATNSAPDAFYVRYYSGHSGRFGHEFLEFDFRVVGDGRSAVARYANNSNYRNDSLIRKEMCVSTLLVQEIKRIIKDSEIMKEDDTKWPQKNKDGRQELEIRLGGEHISFETAKIGSLVDVNESEDPEGLRVFYYLVQDLKALVFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYS9</accession>
    <name>F9WYS9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857716.1">
        <property type="nucleotide sequence ID" value="XM_003857668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYS9"/>
    <dbReference type="GeneID" id="13403866"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88767"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.214"/>
    <dbReference type="eggNOG" id="ENOG502S03H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_5_0_1"/>
    <dbReference type="InParanoid" id="F9WYS9"/>
    <dbReference type="OMA" id="CGVEHPK"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25345" checksum="4474F5C711381723" modified="2011-10-19" version="1">MAHIIITGATGTSGSAVLVHALASPAVQRITILSRRPVALAASQPKAKVIIHKDYAQYPPELLAQLGGATACIWAQGISSRGMQEKEYSEITVDYPLAAAKTFAGLGEKMNFVHVSGEGANMSGTGPFMFGRVKGRAESALLEEQKSSQSLRVYNVRPATIAPQGKYTADRDLSMQDRVVAPVAWALDKVWKNAVIPADKLAAVLVDLALSDGEPLPAGGGIEAEGRLVRNSAVRRLAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ24</accession>
    <name>F9WZ24_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_32960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857511.1">
        <property type="nucleotide sequence ID" value="XM_003857463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ24"/>
    <dbReference type="FunCoup" id="F9WZ24">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="13403082"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32960"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="InParanoid" id="F9WZ24"/>
    <dbReference type="OMA" id="FAVGNIM"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="56808" checksum="45BF9CF15CA43D0A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZB3</accession>
    <name>F9WZB3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_107344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857210.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9WZB3">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZB3"/>
    <dbReference type="GeneID" id="13394966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107344"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1217"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="F9WZB3"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
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        <source>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    <sequence length="476" mass="51974" checksum="47F135A110802CDF" modified="2011-10-19" version="1">MSGLRFLDLVKPFTPLIPEVSVPETKVPFQQRIIWTSVTLVIFLVMSQMPLYGIVSSDTSDPLYWLRMMMASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKSDRELYQTAQKLLAIILSFGQACVYVLTGLYGPPADLGAGICVLLVVQLLTAALIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTVNTGRGPEFEGAIIALVHLLITWPNKQLALREAFYRQNLPNVMNLLATIAVFSVVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALSSNVFLVSQMLYNRLPENLLIRLIGVWEAREGSSQVLPISGLVYYMSPPLNITDALLDPIHTAIFAVYMIVACAAFSKTWIEVSGSSPRDVAKQLKEQGLVMAGHRDESMYRELKRVIPTAAAFGGACIGVLSITSDLLGALGSGTGILMAVTIIYGYFEIAAKEGDMAGLKGMVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZC7</accession>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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                <person name="Oliver R.P."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="422"/>
            <end position="503"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="602"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="14"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="42"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90911.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    </evidence>
    <sequence length="653" mass="73954" checksum="F8B67AF494622AB0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZR1</accession>
    <name>F9WZR1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92663.1"/>
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    <dbReference type="eggNOG" id="ENOG502S27K">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="128"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="271"/>
        </location>
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            <end position="228"/>
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        <location>
            <begin position="448"/>
            <end position="461"/>
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            <end position="482"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="524"/>
            <end position="539"/>
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            <end position="594"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92663.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="895" mass="97809" checksum="9D4DA09AB3000745" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X025</accession>
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            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
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            <name>FAD</name>
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        <text evidence="4">Binds 1 FAD per subunit.</text>
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        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
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        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </feature>
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    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="670" mass="75618" checksum="117BA4AE7CF427C2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X035</accession>
    <name>F9X035_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_83768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857364.1">
        <property type="nucleotide sequence ID" value="XM_003857316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X035"/>
    <dbReference type="FunCoup" id="F9X035">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X035"/>
    <dbReference type="GeneID" id="13394782"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83768"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_0_1"/>
    <dbReference type="InParanoid" id="F9X035"/>
    <dbReference type="OMA" id="DLGQWVG"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13507" checksum="3264A351018C611C" modified="2011-10-19" version="1">MSVLDALKGVLKISLIHDGLARGLREASKALDRRQAHMCVLNEACEEEAYKKLVVALCGEHKIPLIKVPDGKQLGEWAGLCQIDREGNARKVVNCSCVVVKDWGEESQERSILLNYFETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0G9</accession>
    <name>F9X0G9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_32463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857116.1">
        <property type="nucleotide sequence ID" value="XM_003857068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0G9"/>
    <dbReference type="GeneID" id="13395274"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32463"/>
    <dbReference type="eggNOG" id="ENOG502SQ4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057711_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0G9"/>
    <dbReference type="OMA" id="RVVLMYE"/>
    <dbReference type="OrthoDB" id="3009728at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="340" mass="37274" checksum="ECFCD3EC246C7DF9" modified="2011-10-19" version="1">MAGPSFAARIPSWDDLFVRYFPLLSDNFRSALHDNCTTEYNNFLRGSLPGQEQTSLLVSSALATCIMDSKYVTSAMLANMQSAGVLLGILPTVLAMLGSNTVEIALISLRRPLFAACLAAASPAASPVHGSQFYDPIAALKQRAGHVKIPGFGPMVRSIVVTVEWLLVLAALGNVVELGMELGVWTVSSWATKQRYLPLLWTVSVLIVHLAGSASFRLRAHMRQPNGHGPIPFYSRITYWLMDEFTPCAEQTPTLVVWKQETILFLLMSWCTTTLTVVHIVYGVLMLSSLLFISVEDALSVVGRYLISALICRALLAFELRGMSKSSAVQDFDYSDESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0N1</accession>
    <name>F9X0N1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_31579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856680.1">
        <property type="nucleotide sequence ID" value="XM_003856632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0N1"/>
    <dbReference type="STRING" id="336722.F9X0N1"/>
    <dbReference type="GeneID" id="13398086"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31579"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0N1"/>
    <dbReference type="OMA" id="TAPNGFW"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32197" checksum="D9F19CD397EC69B9" modified="2011-10-19" version="1">MSKPTTNKYPRVLLFDIGGVCVVSPFQAILDYEKSKDIPQGYINYCISATNPNGAWQKLERGDILLDDGFFKEWKSDLSNEKRWREYYAKHLAKTRNQSASAGAEEAAFQAPDVPDLDVEWLYWEMMRIAREPDQYMWPALQRLRAAADKSNGQLILGALSNTSIFPPGHAFNDESTPEGKQNKELKSVFDIFVSSAHVGMRKPAEDIYKYAITRLHEMVKLKGYGMGVRPQDITFLDDIGGNLRTAKKLGMGTIKVQLGRADLAVKELEKLTGLDLGLKESKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0P1</accession>
    <name>F9X0P1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdg2427</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_90139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856737.1">
        <property type="nucleotide sequence ID" value="XM_003856689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0P1"/>
    <dbReference type="GeneID" id="13398657"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90139"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_3_1"/>
    <dbReference type="InParanoid" id="F9X0P1"/>
    <dbReference type="OMA" id="CSGCDER"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="40125" checksum="2D1109102BD8A75E" modified="2011-10-19" version="1">MPLQCQTFTAAHQWLSTRPHASSLLLGTPLTEIKSSSPNRGQGLFAARPIPAFTQLLTDTPLVLMTPTDDLPHLYAQFQTFSRPQRELYLALSYTSDSHRAAMMQDKLLQRGFSPDELAEMITVASIMQTNAFNVDLADGLGSTYRAMFAKVARINHACAPNAHVCYYPPDPEYERGRMVVHSLRPLEKGEEVLISYFNILMPRDDRTLRTRKWGFECACPVCDETAPGHRRAEGLRKEFNDFKTEQGKLVTKPSTSAKELSKLTRCIARGQALTETTADFPDLIPALPDVYDGLALLQAKVLLSQNRPFERKEVLELLEKAAVWDAKITGLSSPATAKRLHKLSQFVVKTDERGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0W0</accession>
    <name>F9X0W0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856188.1">
        <property type="nucleotide sequence ID" value="XM_003856140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0W0"/>
    <dbReference type="GeneID" id="13394517"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89225"/>
    <dbReference type="HOGENOM" id="CLU_506425_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0W0"/>
    <dbReference type="OrthoDB" id="4761620at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="538" mass="59913" checksum="B5BDA3B168D6A40A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X176</accession>
    <name>F9X176_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chalcone synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_31911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856469.1">
        <property type="nucleotide sequence ID" value="XM_003856421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X176"/>
    <dbReference type="STRING" id="336722.F9X176"/>
    <dbReference type="GeneID" id="13399134"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31911"/>
    <dbReference type="eggNOG" id="ENOG502SJX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_1_0_1"/>
    <dbReference type="InParanoid" id="F9X176"/>
    <dbReference type="OMA" id="HGWQDRM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="5">
        <location>
            <begin position="236"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36761" checksum="058A2325562DD295" modified="2011-10-19" version="1">MQRAIDPKGGKATAPPDLWIAGLGSQYPPHVLEPKDLYDFATRFHNPETPGLKRLLAINKRTGIETRSAVSTYKDGFGTGKDPPTIADIDSFFRVVGVDLTVQASRKALQEWGGNKSQITHTVGVTCTSQGNPGYDVLVNQALGLEASIDRTLLHGVGCAGGLAIMRAAGQIAAGATAFGRPARILAFACELSTPHMRCELAAAERKPSDQVGIAGALFSDAAAAFVLTNRSCTVISRDVPSLIKQAVKPVLDGMLLGCRVPSTDNFDWALHPGGTAVVDGVKEAMGLTEHQLRATREIYRTKGNSSSPTVLIVLDRLRSMDSSRGNIVAASFGPGLAIEMALLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1P5</accession>
    <name>F9X1P5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_33113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856851.1">
        <property type="nucleotide sequence ID" value="XM_003856803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1P5"/>
    <dbReference type="STRING" id="336722.F9X1P5"/>
    <dbReference type="GeneID" id="13398410"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33113"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2100"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="F9X1P5"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395273" description="Agmatinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44087" checksum="3F5482296CEA6D53" modified="2011-10-19" version="1">MALRLLTSVLALSTLTTAHGDHSHDHHEAEDPQQPFIGWTKEDLDAKWGTDWGFSGISTFAHLPHIRCLQHPSQTYDIAILGAPFDTAVSYRPGARFGPRAIRAASARQTAMRGYNPRANLNPYTSWATVLDCGDIPITPFDNSLAIHQMSLAFSQLSNSPVPQSSFSSNIPYRHFPKLITLGGDHSIALPTLRALQAVHGPIAVVHFDAHLDTWHPAKYPTAWLNPDDSTFQQSFMTHGTMFWLAHNESLLLPHKSVHAGLRTRLSGAEDDEDDDAQGWSRIACDDIDDLGARGVAEKIMKHVGTEVPVYLSIDIDVIDPGLAPGTGTPEPGGWTTRELIRVLRGIEGLNVVGADVVEVSPAFDGAGEVTALAAAQVVFEVLTSVVKRGLSDGGEERRGKGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Q1</accession>
    <name>F9X1Q1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_90301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856846.1">
        <property type="nucleotide sequence ID" value="XM_003856798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Q1"/>
    <dbReference type="GeneID" id="13398405"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90301"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="InParanoid" id="F9X1Q1"/>
    <dbReference type="OMA" id="AVYNTCY"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39087" checksum="26C399F469B56F65" modified="2011-10-19" version="1">MTEDFGTETAISFCDGQSPALLPLRDIHDEVIAAADIVPVAEYIALDCELSGTALLVRHDARTTDGYSSRDRSVIITGGASGLGEATATKFIQHGAYVTIADMDDALGERLVANLGDRATYVHCNTTDWTSSAAAFKHAARHAPSKTLDIAVLFAGVGGESKGLIDLALEQPLPSLSADDDPAQPAHKAIDVNLIGVYISTYLSLHYFRLPAAQPQTFTKSLVLISSMMGYIDGPYNTGYSASKFGVRGLFCSVRGQAHKVNARINNIAPGYILTPLTQRVHQIERPDQPSKATGLVLPWASIDHVVDGVGRCAVDEKTAGKTLAIVPSGVVDMEEDIPTGYGGAKWAQVLEEEGFTKLTTLFPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Q3</accession>
    <name>F9X1Q3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CYP-73</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_34026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856836.1">
        <property type="nucleotide sequence ID" value="XM_003856788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Q3"/>
    <dbReference type="STRING" id="336722.F9X1Q3"/>
    <dbReference type="GeneID" id="13398394"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34026"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="F9X1Q3"/>
    <dbReference type="OMA" id="AYIMRYV"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF188">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="58496" checksum="EB27D3A2684FAFA2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X229</accession>
    <name>F9X229_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_25795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855716.1">
        <property type="nucleotide sequence ID" value="XM_003855668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X229"/>
    <dbReference type="STRING" id="336722.F9X229"/>
    <dbReference type="GeneID" id="13403656"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25795"/>
    <dbReference type="eggNOG" id="ENOG502SJ2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_1_1"/>
    <dbReference type="InParanoid" id="F9X229"/>
    <dbReference type="OMA" id="YMGFPTD"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31713" checksum="DEBC5D09FC86921A" modified="2011-10-19" version="1" fragment="single">RPYHRRLEVLWASNAFFMVVAFILAIKLYTTDCRDPSLQVYSPANGAVSYIAEHKFTPALGKLTEYMGYPDDETDRKWQELYQYNRSVITKEEAKHLSTPTMALPGTEDYLVELEVYHQLHCLNVLRKLLYPERYHLLERVSWKNGTINRESYGFKHWDHCVETLRQTLVCHADVAPLSWHVNVPFNRGIYPRLASTHTCRNFSQINKWAEEHQAPEFTQKIKNFTELQQIIDGTDIDHSTEEDLQDKYELFPGDQWFKHWRENPYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2D8</accession>
    <name>F9X2D8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_99173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2D8"/>
    <dbReference type="FunCoup" id="F9X2D8">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2D8"/>
    <dbReference type="GeneID" id="13403426"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99173"/>
    <dbReference type="eggNOG" id="KOG1969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004894_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2D8"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="854" mass="92948" checksum="ED9636B941D369F6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2F1</accession>
    <name>F9X2F1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855016.1">
        <property type="nucleotide sequence ID" value="XM_003854968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2F1"/>
    <dbReference type="STRING" id="336722.F9X2F1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108135"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.732"/>
    <dbReference type="eggNOG" id="ENOG502SBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152072_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2F1"/>
    <dbReference type="OMA" id="DKFFTHE"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="110" mass="12414" checksum="8462E6D454229249" modified="2011-10-19" version="1">MQPTLARMVGGGYLGKDGRSGVTPWRQPVTYETFRSKYGPQYKIPYTFYGITTQHILRAGQLAGGFGLAAGIFAIYFFDGIPKVQRDILDKVPFIRSFYNKEIPPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2M1</accession>
    <name>F9X2M1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_84402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854739.1">
        <property type="nucleotide sequence ID" value="XM_003854691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2M1"/>
    <dbReference type="FunCoup" id="F9X2M1">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2M1"/>
    <dbReference type="GeneID" id="13403719"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84402"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="F9X2M1"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="67"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49086" checksum="28E83B6249B3DDCA" modified="2011-10-19" version="1">MSSVKRRKLDVNQEQLEGEEDIDDGIVAADDESTDKTFADLGVVDSLCEACTALGFTKPTAIQREAIPIALEGKDIIGLAETGSGKTAAFALPILQELLDKPQPMFGLVLAPTRELAYQISQQFEALGSLISVRCAVIVGGMDMVPQAIALAKKPHIVVATPGRLLDHLENTKGFSLRQLKYLVMDEADRLLDLDFGPILDKIFQVLPRERRTMLFSATMSTKLNNLTRAALQQPVKVSISSSSYQTVKNLMQRYIFIPHKFKDIYLVYLLNEFAGQTCIVFTRTINETARIAFLLRALGRSAIPLHGQMNQSARLGALNKFRGGHRDILVATDVAARGLDIPSVDLVLNFDLPPDSKTYVHRVGRTARAGKSGVAISVVTQYDIEIYQRIEKALGKKLEEHPTERDEVMVFAPRVGEAQRIAVTEMKNEHEKRGGATAPSSKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2P2</accession>
    <name>F9X2P2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_35953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854827.1">
        <property type="nucleotide sequence ID" value="XM_003854779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2P2"/>
    <dbReference type="STRING" id="336722.F9X2P2"/>
    <dbReference type="GeneID" id="13396012"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35953"/>
    <dbReference type="eggNOG" id="ENOG502SCBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004633_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2P2"/>
    <dbReference type="OMA" id="RCGGMIH"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29450" checksum="24489892BC48E6CC" modified="2011-10-19" version="1" fragment="single">MSSFLRLCFPNMKGLINCMHSKLMLLFHPDKLRIAIPTANLLNFDWGETGQMENSVFMVDLPRLADGKISEAGDLPAFGQELIYFLEQQGLDDDVRTGVLKFDFSATKDMAFVHTVGGMHFRDEAERTGLMGLSKAVKQLNLATQDLELDFAASSIGRLNDNYLRDFHSAAKGISLIAQAAEAKSKAASTFFDRKKASTVAKPDNVREKVRIYFPTASTVRVSTAGAAGTLCIARNYFEGSTFPRACFRDYKSTRTGLLSHNKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X311</accession>
    <name>F9X311_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855450.1">
        <property type="nucleotide sequence ID" value="XM_003855402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X311"/>
    <dbReference type="STRING" id="336722.F9X311"/>
    <dbReference type="GeneID" id="13399827"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90916"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.782"/>
    <dbReference type="eggNOG" id="KOG4497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024072_0_0_1"/>
    <dbReference type="InParanoid" id="F9X311"/>
    <dbReference type="OMA" id="TVWIWDL"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="532" mass="58473" checksum="9D2F3C808B8F3A53" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3R9</accession>
    <name>F9X3R9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_68456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854971.1">
        <property type="nucleotide sequence ID" value="XM_003854923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3R9"/>
    <dbReference type="STRING" id="336722.F9X3R9"/>
    <dbReference type="GeneID" id="13403458"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68456"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.647"/>
    <dbReference type="eggNOG" id="ENOG502QTJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_2_0_1"/>
    <dbReference type="InParanoid" id="F9X3R9"/>
    <dbReference type="OMA" id="DGWGMVG"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="544" mass="60919" checksum="2AE8A1C2825AD615" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3U6</accession>
    <name>F9X3U6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_68734</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855061.1">
        <property type="nucleotide sequence ID" value="XM_003855013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3U6"/>
    <dbReference type="STRING" id="336722.F9X3U6"/>
    <dbReference type="GeneID" id="13400966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68734"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="InParanoid" id="F9X3U6"/>
    <dbReference type="OMA" id="YELRMIR"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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            <end position="167"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="490" mass="55609" checksum="F58ED5878D9F3583" modified="2011-10-19" version="1">MDSQYETKELSIQIRASKCVDKYPAKSHARRIAEKLGRDHGLIVLAATKAANWPNSDMPAPFRQDRYFYYMTGVNEPDCFVSYSIEDDVLTLWLPPINEDRVLWYGRGSTTEEAMERYDIDDARYLKEKSFERGRPIFERYNMRTLGRMCGLTDTMLLTLGKRPHEPSGLRTAIDACRVIKDLHEIDLIRRANVISGEAHVNVMKGLHRFTNEADVEAAFMQTCIARHAKIQAYDPIAGSGANAAVLHYSENEADFGDGQTIVLDAGCEVERYASDVTRTMPINPRKPGYWPSREAEEIYNLVESIQESCIGQLKPGKEFREVFWHAHHMVIDGLLKLGILKGDRDDIFHTGTSRAFLPHGLGHHVGLEVHDVDPTPNPSLSTEEDFAINMAPSHSDIHKLDAHLLERDMIITVEPGIYFNEFLIEHFYLSKPEHAQFIDKKVLKRYMQVGGVRIEDNLLITKDGCENVTTAPKGKAMLRIIREAASSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X479</accession>
    <name>F9X479_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_67942</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="580" mass="64341" checksum="6274CB65C782C0E2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48255" checksum="9FBD5802AA28D064" modified="2011-10-19" version="1">MASEEIDLYEVLNIQRGATKAEIKKAYHKAALSSHPDKVAPEEREQADIAFKSISQAYEILSDDDTRHLYDQHGMAAFDKSSSMGGGQPDLDDLLAQMFGGMGGGMGGGFEGFPGMGGMGGGGGGPGRPQRKTKGRSERQQYQVTLEELYKGKTTRFASTKNIICSHCHGSGGKSEKTKPKTCETCKGRGQTTRLQPVGPGMVTQQTVPCNTCAGRGSFYADKDKCKRCKGVRTVKEKKILEMYIPRGAREGEQIILAGEADQSPDDSEPGDIVFELVEAQHEVFHRAGSDLQAEVEISLVEALTGFDRVVLTHLDGRGLQLCVKQPDGKVLRPDDVIKVVGEGMPMKKSDARGDLYLTLKINFPEDGWLKTPAEVEKVRAVLPKVEKKEYKVGETPEVIEEVLDWEVVQDLEGFGAGSDDPRAAGAEWEDDDEGAEGPQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4T6</accession>
    <name>F9X4T6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855195.1">
        <property type="nucleotide sequence ID" value="XM_003855147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4T6"/>
    <dbReference type="GeneID" id="13400512"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103488"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1160"/>
    <dbReference type="eggNOG" id="ENOG502S0MQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064566_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4T6"/>
    <dbReference type="OMA" id="YIRCNQL"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="288" mass="32263" checksum="45AEE1BA48FF8FAF" modified="2011-10-19" version="1">MVKCHPQREDVAARLDYIDLLRAMYPADDELLMDQETEVMLSNARTWCEDDAIERPNMTATISLSLVLTFSTAAKQDSRKLVLTIELPLAALEPVSAEVPLEGRLRVGADWLTKAEALRLQFDLPEHDILSAIDIVRYRATEHLATLQQTAVVAGDISGPEVRAWFYFPSISTRAKRDDLVNHAPSFGLTGFLLAGKPGVLCLEGGAQRIDDFMKFIKTESWGDIPPGHKKVSEVLRESCTERSFSRMEEITDQLEKRGQRSNRSDMKGLEQWLAARGLGESFAKVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X575</accession>
    <name>F9X575_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854002.1">
        <property type="nucleotide sequence ID" value="XM_003853954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X575"/>
    <dbReference type="GeneID" id="13404340"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103872"/>
    <dbReference type="eggNOG" id="ENOG502R98N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840018_0_0_1"/>
    <dbReference type="InParanoid" id="F9X575"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="14786" checksum="636DBD2222B897DB" modified="2011-10-19" version="1" fragment="single">MATEPPPHSPLPLPTIQSALLNSVLSTHASKLRLDYSASILVSNTSLAASLAQWLADEKRDMPHSIVAVSPSSQSESGIPADLAKAASISVVESAPDDVFTHAFAHVEDGSDRDAVLWALKRCFYGLIPKGIAIVSIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X584</accession>
    <name>F9X584_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_70266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854007.1">
        <property type="nucleotide sequence ID" value="XM_003853959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X584"/>
    <dbReference type="STRING" id="336722.F9X584"/>
    <dbReference type="GeneID" id="13395463"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70266"/>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="InParanoid" id="F9X584"/>
    <dbReference type="OMA" id="ATCPIGN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="315" mass="34025" checksum="6229A3BD4F0DA283" modified="2011-10-19" version="1">MKILITGAGGLVGQLLAELLLNDNHTVILADIFDPPIPAAASNKANATTLKADYYETPNAGLSADLDAIYVFHGIMSAGSEADFDLGMKVNLHSTLRLLEAIRATCPGVRVIYASSTAIYGQPLPELPSDSTVPTPEGSYGCQKAVIEYLINDYTRRGFINGWSLRFPTISVRPGKPTQAASSWMSGIIREPLQGKESLLPCEDDFKSWLCSPKTMGKNLLHVLTLPRDALPSHIRQVMLPGITATVKEMLEALRTVGGDEAVALVKREKMSPEIEAVLTSWPNCFDVSRALSLGFHPDQGFLGAVEDFAASLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5E7</accession>
    <name>F9X5E7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_28269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854662.1">
        <property type="nucleotide sequence ID" value="XM_003854614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5E7"/>
    <dbReference type="STRING" id="336722.F9X5E7"/>
    <dbReference type="GeneID" id="13395848"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28269"/>
    <dbReference type="eggNOG" id="ENOG502RJRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082154_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5E7"/>
    <dbReference type="OMA" id="IGCQRSE"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="175" mass="20212" checksum="C1B1F9C867AC67E0" modified="2011-10-19" version="1" fragment="single">VLPMRRQADNFVTCFWEFVHPLFPVLHRPTFQRKYEQLWTDNGPEAHSEETSEAEEAAFNSTLNLVFAVGCKFSSHLDPGQKSSVSDNFYQRSRQAYPFDILDSTSISLVQMLLLMAVYLQSTEYASRCWNSAGLAIRMAQSLGLHVDQIGRKGNTQLEVQMRRRIWHTCIHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Q6</accession>
    <name>F9X5Q6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_99568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853864.1">
        <property type="nucleotide sequence ID" value="XM_003853816.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5Q6"/>
    <dbReference type="GeneID" id="13404203"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99568"/>
    <dbReference type="eggNOG" id="ENOG502QQX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000488_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5Q6"/>
    <dbReference type="OMA" id="QFQVNVW"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391146" description="alpha-1,3-glucan synthase" evidence="9">
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            <begin position="19"/>
            <end position="2306"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1886"/>
            <end position="1906"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1949"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2050"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2095"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="2127"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="2160"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="2204"/>
            <end position="2224"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="2231"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2279"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="66"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="79"/>
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        </location>
    </feature>
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            <begin position="1630"/>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP88840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2306" mass="259265" checksum="69844AEA917EC547" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Y6</accession>
    <name>F9X5Y6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_99379</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 18 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003853592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Y6"/>
    <dbReference type="FunCoup" id="F9X5Y6">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5Y6"/>
    <dbReference type="GeneID" id="13400895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99379"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_007818_6_1_1"/>
    <dbReference type="InParanoid" id="F9X5Y6"/>
    <dbReference type="OMA" id="CQYAAGS"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395362" description="chitinase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP88616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="377" mass="41352" checksum="A9389D951B8AD79C" modified="2011-10-19" version="1">MPSFASLVLAATGLFAAATNAQFNAAAKTNVAIYWGQGPNQLRLLEHCKRPAVDIINIGFINQFPDQTGSYPGSNFGNACYANVYSDPKTGQPTKLYSQCPYVTFIQDSWARSRNIGPDIKACQQTYGKKILLSIGGAYPQNYYLKSDTSANAFADFLWKAFGPVQTGYTGPRPFGDAVVDGFDFDIESYISPAPSGVSDYQTRGYISMINRFKNVLFKQYTSKSFYLSAAPQCIVPDAHFATVMKSAWFDFMFIQFYNTPQCSARAAINKAKGTGTADISFDTWHNSPASLNPNVKFYIGLPGAPAAAASGYYLNPAEAQSVIRRFFGRAKFGGVMVWEATYDYTNTVCGRPYGGIMKVSIDRVSETIPFCHAMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X633</accession>
    <name>F9X633_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854624.1">
        <property type="nucleotide sequence ID" value="XM_003854576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X633"/>
    <dbReference type="GeneID" id="13395811"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91380"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.113"/>
    <dbReference type="HOGENOM" id="CLU_1020161_0_0_1"/>
    <dbReference type="InParanoid" id="F9X633"/>
    <dbReference type="OrthoDB" id="10271753at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="273" mass="31254" checksum="C4C2563478E84148" modified="2011-10-19" version="1">MGPKRATAVRGPQHTWTFENRMAAYILCYPIDQYAASNRKPIFDHIYGGDIGKTALTAQARESQKLQRDHPDATIPRRHADWDRITRVPLSRQDQITWDSILQRIGQAIEDLELGELEPQPAATGNNQMQAPVPNQVQANPAPNVVAHNPTIANNFVHKIELFEAFGIYIWRPNVLMTPDQRNINATTSTTILPEWVWTAEDTRRQLLICFTDTCATCRGRTGEAYLTEQEIRWIETRDDLPPQFWQCHKIPNTSTLTAEESRLMDDEEYGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6D0</accession>
    <name>F9X6D0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_70000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853899.1">
        <property type="nucleotide sequence ID" value="XM_003853851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6D0"/>
    <dbReference type="FunCoup" id="F9X6D0">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6D0"/>
    <dbReference type="GeneID" id="13395554"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70000"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.651"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049046_1_0_1"/>
    <dbReference type="InParanoid" id="F9X6D0"/>
    <dbReference type="OMA" id="GDCEVNQ"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="344" mass="38540" checksum="1843753CA043A66E" modified="2011-10-19" version="1">MVLHNPNNWHWVNKDVSAWTKDFLSQDLIGLKAESNGVKVEVSKVLSMDGDVDVSQRKGKVITIFDVRLQLEWTGSIPVKEKQENDDGVEEETEGKKDVSGTITIPEVAHDTEEDEYVFEVEIYSSSLEKEPAKELVRKEITPQLRKHLRKIGPALITEHGKDIQHAPGSNPSSGFSTPRTLQSSSVNKSSASTSAPSTSTTSDRKVNVTSLSDTQEFRTTADQLYQTFTDPQRIAAFTRGAPKLFEGAKVGGKFEIFGGNVSGEYTKLEEPKSIEQKWRLAQWPADHFSTLNIKFEQNDVDAVTVMRVEWSGVPVGQEEPTKRNWDEYYVRSIKQTFGFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6E4</accession>
    <name>F9X6E4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_91827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854361.1">
        <property type="nucleotide sequence ID" value="XM_003854313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6E4"/>
    <dbReference type="GeneID" id="13404246"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91827"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.664"/>
    <dbReference type="HOGENOM" id="CLU_1361386_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6E4"/>
    <dbReference type="OMA" id="RRCAINT"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="201" mass="21172" checksum="28D1FB31B5909E0D" modified="2011-10-19" version="1">MAGLRETADEGQRCGDVDDQAMELERTDVDAAIDEDETLARALTPARKSEDPAASKKHASPISRILNNAPIEHQTPQSIAMARTKNPNRIVRRNGSLYKGGRLLSKGKKNGITKKKRAPPPPPPPPPKKPTSKSGGRCPSRCTECKRGHRKCDGARPCERCITVGRPQNCVYQGTQPPSAAAASTGNGSGSANTGGAGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X711</accession>
    <name>F9X711_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854077.1">
        <property type="nucleotide sequence ID" value="XM_003854029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X711"/>
    <dbReference type="GeneID" id="13404416"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108849"/>
    <dbReference type="eggNOG" id="ENOG502RH8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446859_0_0_1"/>
    <dbReference type="InParanoid" id="F9X711"/>
    <dbReference type="OMA" id="DHAPRQA"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="523"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="643"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="703" mass="77841" checksum="283D18B9F136EE20" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X757</accession>
    <name>F9X757_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA2/NAM7 helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_20505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854103.1">
        <property type="nucleotide sequence ID" value="XM_003854055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X757"/>
    <dbReference type="GeneID" id="13404527"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20505"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001066_2_0_1"/>
    <dbReference type="InParanoid" id="F9X757"/>
    <dbReference type="OMA" id="EWIMVEA"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="300"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="692"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="971" mass="108970" checksum="E2C50B99382497CD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7E4</accession>
    <name>F9X7E4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_38510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854183.1">
        <property type="nucleotide sequence ID" value="XM_003854135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7E4"/>
    <dbReference type="STRING" id="336722.F9X7E4"/>
    <dbReference type="GeneID" id="13404446"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38510"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_1"/>
    <dbReference type="InParanoid" id="F9X7E4"/>
    <dbReference type="OMA" id="HFSVAAY"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L27" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="171" mass="18696" checksum="E7CD53D079BF8E66" modified="2011-10-19" version="1" fragment="single">SPLMHAAAEGHDEVVRLLLQKPSSRLDDQDEAGFTPLAWSAYSGNAATVRLLLDTEEAEIDTKNNVGHTPLTLAAIQGDEEIFKLLLDPGECDLNAERTNDQTILIRAAREGYLKIVEMLLATTKVDIEARDIHNRTALLAATSRHHTEVVACLLDHGANVDVMDNCGWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7J1</accession>
    <name>F9X7J1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_92195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854131.1">
        <property type="nucleotide sequence ID" value="XM_003854083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7J1"/>
    <dbReference type="GeneID" id="13404470"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92195"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1113"/>
    <dbReference type="eggNOG" id="ENOG502S3RH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_1_0_1"/>
    <dbReference type="InParanoid" id="F9X7J1"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34966" checksum="FE78836230016F83" modified="2011-10-19" version="1">MDVPDEDEDDLEDIIRGEEPEKIQDRDKSEEEQDAPCWKWTTSPCAASPVKSFAQIHGYDYKFYHAQHMKGYYDTWIRPHLLASLLRDNDYDFVMTMDADVTITHKDVPLEWLFNRWNITERTSIALPWDVETQIWETDYIRGKDSRGLTVLNAGVVIVQNLPHTLEILQAWGDCPTETRYEGCAHWKTEWSHEQRAFSEYIRYDFNPDGDNIVPIACDDAMSWPGATEERPGPFNSVVLSDCNGNFLRHHTWHKERPRGEFQDAVMQLMIRLLQDKVKQNMDTILTEERKERKGGGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7K1</accession>
    <name>F9X7K1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_69382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854585.1">
        <property type="nucleotide sequence ID" value="XM_003854537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7K1"/>
    <dbReference type="STRING" id="336722.F9X7K1"/>
    <dbReference type="GeneID" id="13395772"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69382"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.181"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="F9X7K1"/>
    <dbReference type="OMA" id="VIMLCKT"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="254" mass="26613" checksum="F5E0F9EA9428471F" modified="2011-10-19" version="1">MPLDNEISGRLALVTGASGGIGAACARDLFVHGASLALTYSSNKASVDQLIDELKASDNGRKLTAHKADMASDGDLNRLFDEIRTEHGHGPDILIANAGYGKRTSNILEIDIGEWDYTINVNLRASFILTKLAVSHMIEKKWGRIVYISSIAAGGTSINGCHYSASKAGVQGLSKNLAIKLAKDGITCNDVAPAMITGTGMIPDEAFLKGTPGDVSNIPVGRSGSTQECANVVTMLCKTGYMTGQSILLSGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8C6</accession>
    <name>F9X8C6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_104094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852918.1">
        <property type="nucleotide sequence ID" value="XM_003852870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8C6"/>
    <dbReference type="GeneID" id="13397239"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104094"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="F9X8C6"/>
    <dbReference type="OMA" id="MEMAGYI"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33110" checksum="A826840B65FD7415" modified="2011-10-19" version="1">MSFRQCKEVSPQCPVEATTYGYYPVLSGNIALLVVFAITFFVQLFLGIRARLPAFTSVVAIGCMGEAIGYGGRLMLNENPWDDTGFRIQIVCLILSPSFLAAGIYLTLKHIVLTLGPECSRLKPRLYTWIFISCDAFSIILQAAGGGVAASASADLVNIGNRIIIAGIAFQVATMFICMCLALDFALRLGKKAKLSKANGARLERVQTYATKPAFYFYLSLSGLAFLTIFIRSVYRLPEMAGGWGNPLMQREKEFLVLDGAMVAIAAVAMSIAHPGIFFPEMKTKRPVSPTSSSSDEEKAAQDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8D2</accession>
    <name>F9X8D2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_39964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852921.1">
        <property type="nucleotide sequence ID" value="XM_003852873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8D2"/>
    <dbReference type="STRING" id="336722.F9X8D2"/>
    <dbReference type="GeneID" id="13400462"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39964"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.275"/>
    <dbReference type="eggNOG" id="KOG3258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_2_0_1"/>
    <dbReference type="InParanoid" id="F9X8D2"/>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="124" mass="13284" checksum="4BD223F84F90AB9C" modified="2011-10-19" version="1">MAPKGKGGDKSKSKDKDASAGADKGKVKGAQTINVRHILCEKHAKKEEALAKLNDGGKFDDVAREFSEDKARAGGALGWKTRGNLLPEFENVAFELAASTTAKPVWGEAKTSEGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8G1</accession>
    <name>F9X8G1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_39840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853396.1">
        <property type="nucleotide sequence ID" value="XM_003853348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8G1"/>
    <dbReference type="GeneID" id="13397337"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39840"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="F9X8G1"/>
    <dbReference type="OMA" id="FNPGNLQ"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34608" checksum="3CAD35DE9769DBF4" modified="2011-10-19" version="1">MFIPKPTLTEANLPDQSGRVFIVTGGYAGVGYELSRILYNANGVVYVAGRSADKGEKAISEIKQIVPSSKGRLEFLKIDLADLTSIKPSVEGFLAKEERLDVLINNAGVMTPPAGSLTTQKYDLQVGTNCLGHHLLTKLLHPLLTKTAESSPPASVRVAWAGSLAVDAFSPKGGVTMTAEGNHEVGKKSIQTLYGESKAGNYFLAAQFAKRNPIPADGKGGVLHVAFNPGNLKTELGRHQHSAAMWVMGKTVLYPAVYGAYTELFCGWSPELTKEKNGCYVVPWGRLAGVRKDVQREIDVEGGNASKFYEWCERETSKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8G6</accession>
    <name>F9X8G6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853018.1">
        <property type="nucleotide sequence ID" value="XM_003852970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8G6"/>
    <dbReference type="STRING" id="336722.F9X8G6"/>
    <dbReference type="GeneID" id="13397339"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92604"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.479"/>
    <dbReference type="eggNOG" id="ENOG502SJU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089363_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8G6"/>
    <dbReference type="OMA" id="FKVWAEP"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24557" checksum="565E90ABF21DD046" modified="2011-10-19" version="1">MSFHVKRTETKHQDPLKQYRGIRSTTWATPAPGKSVREIQITHTPTALQKIPDNLNYLTPPPHWHWYQDEYFHIKEGRYIFTLEGITTTLSATSPQPIHIPARARHTFKVDPTHSGPCTIEISTTISPRGADDRFFRNIYSYLDDCYVQNLSPSLPQLLLMLDAAEISMAFPGPGWIARPASWVFGVLVGRWLGGLLGCRASYEEYWSEEGRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8I0</accession>
    <name>F9X8I0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_92614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853387.1">
        <property type="nucleotide sequence ID" value="XM_003853339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8I0"/>
    <dbReference type="GeneID" id="13397347"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92614"/>
    <dbReference type="eggNOG" id="ENOG502RQ03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071387_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8I0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="37160" checksum="CFB65132988D1680" modified="2011-10-19" version="1">MRFAGAKAIAAPKWSPDSPPHASASSDTSCRSILNVFAASHHRRTAVFNVKMPFGAIRDGFLPSSARLQSPRYAAVKEYDENERQSSFEETNSDTFDRPGARGNQWRDLVRMLLLGVTVFITAFAGTSAANAFRIAGCQVRKEHHFQNHAASAAVSVPEKGTRIPFLENVPMKPSNFTPDELLGLPALVESNKAWDALIGPSKGYIEIAHPEQYGLPPGVRHPTDPDKSVYGLAMTHQLHCLIRIRKIYYDFVDGRLTAESFHASPPLELTGILKLNHGSLHLNHCFDYLQEGISVDDSKVFLDALVIVESDIKDIEDHTSVSQVSRLHGHLIYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA07</accession>
    <name>F9XA07_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_41082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853319.1">
        <property type="nucleotide sequence ID" value="XM_003853271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA07"/>
    <dbReference type="FunCoup" id="F9XA07">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="GeneID" id="13399308"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41082"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="F9XA07"/>
    <dbReference type="OMA" id="RDDEWAY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="543" mass="60462" checksum="5B64A96052E0039E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA26</accession>
    <name>F9XA26_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_58320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853099.1">
        <property type="nucleotide sequence ID" value="XM_003853051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA26"/>
    <dbReference type="FunCoup" id="F9XA26">
        <property type="interactions" value="1330"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA26"/>
    <dbReference type="GeneID" id="13399972"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58320"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.657"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="InParanoid" id="F9XA26"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="696" mass="78256" checksum="9D3920B4041ABDDB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAA8</accession>
    <name>F9XAA8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_39839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853284.1">
        <property type="nucleotide sequence ID" value="XM_003853236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAA8"/>
    <dbReference type="GeneID" id="13399952"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39839"/>
    <dbReference type="HOGENOM" id="CLU_028200_25_2_1"/>
    <dbReference type="InParanoid" id="F9XAA8"/>
    <dbReference type="OMA" id="RCINSPA"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="18616" checksum="DE9DD564F8E550BB" modified="2011-10-19" version="1">MYHYGLGRDMWMVPTDSILAWSKPPILTSSQWFFASMPLYFVAAFCTKLSLILLYLRIWPDDTGTNRIFRMGCKVIGLLLLLTAFISVLTLIFGCNPISDAWRYANRAGGKCIDRVAAGYAFGGLNVIFDLIVILLPIPRMIALKVSMRQRIGYVFGSAEWDAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB59</accession>
    <name>F9XB59_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1214 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852387.1">
        <property type="nucleotide sequence ID" value="XM_003852339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB59"/>
    <dbReference type="GeneID" id="13394164"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93564"/>
    <dbReference type="eggNOG" id="ENOG502SNN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_991125_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB59"/>
    <dbReference type="OMA" id="QDDSWEY"/>
    <dbReference type="OrthoDB" id="2018906at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="entry name" value="Domain of unknown function DUF1214, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160935">
        <property type="entry name" value="VPA0735-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="189"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="281" mass="30909" checksum="FBDE42F02E284684" modified="2011-10-19" version="1">MSTRRLDTKHLLRFMFPALPECYNFKTYRATASAAGGEPGSGAEGSRSGSFLGIDSLAQQLEFAARSVPYTQAVAYSDRFRVASILSQAGLYNGHYHQPAEVNLISAGAIANSSVTLQRQTSDAIQQQGNGWTLQRDAYQGNYGTKYATSAYVALEGYQQLTQHQALYPEFEGRGFSSVFHLEPNASLLVTFSRKPQLKEAGFWILTAYGANQYLIANVLDRYVVSDRTSSLTFQDSGKMVYGPDADEQEDGAFEILLQPADLPPPKNWTSNWLPVESSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBJ0</accession>
    <name>F9XBJ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852400.1">
        <property type="nucleotide sequence ID" value="XM_003852352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBJ0"/>
    <dbReference type="GeneID" id="13394176"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93585"/>
    <dbReference type="eggNOG" id="ENOG502R9W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726061_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBJ0"/>
    <dbReference type="OrthoDB" id="3650755at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="381" mass="43413" checksum="FFDE8F776FD4FD3B" modified="2011-10-19" version="1">MAEDWKERFHDSETTAASDRQKVQWRKSEIPSLPIVRALSIAQTVISPSIPVVHRSPFHFDNCRSPGTCPAHDSRIIRRARQIMARLGDFELSGILYAGCDFDAWRDKTDAWLRLRGLESFVSRTKKGEGRSGMAQRLKEKARDAICERVDRAIIRRLPTTIKPDDHLQNFWKQLEEQAKPFRFEDLTPELRCKVYSSILGADASYNLSQWTPSCSLPAILSVCSTVRKEAMPVYYSSTEFRATCKVSGGRDRGIERTRNTMTSWTRSLAHGALQHLRSINLYVAGLSPRTTGPVESFGNLLQFRFSPITGLTCDEWQSANPEVALHYHKSLNVQAKERLRKSLARLEKYREVTSLRGEVLVMAIVDILELLEDGKMEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBS4</accession>
    <name>F9XBS4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_80934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852292.1">
        <property type="nucleotide sequence ID" value="XM_003852244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBS4"/>
    <dbReference type="FunCoup" id="F9XBS4">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBS4"/>
    <dbReference type="GeneID" id="13396834"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80934"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.609"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="InParanoid" id="F9XBS4"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="303" mass="32817" checksum="BD8A2D010828B9C7" modified="2011-10-19" version="1">MFRVATPALRAGASSLRPAVVASPALQSANYATLREIEGRLKSIKNIEKITKTMKIVASTKLTKAQRAMESSRAYGSTSDTVFKEAETKAIEGTDKKSLLVVCSSDKGLCGGIHSGLSRAARRMFDQDGVNYDLVIIGEKAKAQMSRSNPKNMQLSFAGIGKDVPTFSDASAIADQISLLPEEYSSIKILYNKFVNAQSYEATVIEAFSEEAILESPNFSNFEVDDAVLGNLREYALANSLYWALAEGHACEISARRNAMDNASKNAGDMIDKFQILYNRTRQAVITGELVEIITGAAASEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCD8</accession>
    <name>F9XCD8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_72564</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852464.1">
        <property type="nucleotide sequence ID" value="XM_003852416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCD8"/>
    <dbReference type="FunCoup" id="F9XCD8">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCD8"/>
    <dbReference type="GeneID" id="13394127"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72564"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.728"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCD8"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="239" mass="25948" checksum="418FA3DF09BEAF3F" modified="2011-10-19" version="1">MSTLPEWKSSLISLTLSSNILTFGTFTLKSNRQSPYFVNCGLFSKARSIRAISSAYAHTLHEHALSDPSFSFDVLFGPAYKGIPLCATTAEKLAGIDEKKWGEVGYSFNRKEVKDHGEGGLMVGESMKGKKVVIIDDVMTAGTAIREAIDIIKAQGGELVGIIVAIDRQEKLPSAAEKEGKGDDGSPRGSAIGEVRRETGVPVLAVLTLSDIMEGMRGLGREEEVKRMEEYRRQYGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCS1</accession>
    <name>F9XCS1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_72843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851939.1">
        <property type="nucleotide sequence ID" value="XM_003851891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCS1"/>
    <dbReference type="GeneID" id="13393716"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72843"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="F9XCS1"/>
    <dbReference type="OMA" id="EDSKRIC"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="504" mass="55462" checksum="8A6BCB4B27D2CCBE" modified="2011-10-19" version="1">MSPFGDISWLTNATQNKQIRRSTDKVILVILVWVYFLQIIDKSVLGYGATFGLKEDTGLVGQQYSLVGSIAAMAQLGWQPFSSYLIVKVPHRILMPCLVLGWGIAQTCMAACHNYGGLLAARFFLGLFEAGCLPLFSIITSQWYRRAEQPMRVAAWYSTNGIAGMAASLLSFGLGHVKSPLIESWQLIFLFVGLITVVSAPFVYWKLDNDIPSARFLSEEQKPKAVERLRANQSGTGSSEFKMKHVWEMLFEPKTYLWIGMSLLLNCGASVTNIFGPLIISGLGFDKYRTALLSVPFGAMQFLVIIFASWAAQRFKNKSVILTCLTLPVIAGLAMLYTIKHTDGNQGALLAGYYLLAFLFGGNPLIVSWIVGNTAGTTKKSVLMSVYNAASSAGNIIGPLLFNSNDAPEYKPGVRAVLGLFVALAAVIIIQVFNLMFLNKLQSRKRVKNGKPAQITDWSMKDEYHNADEKLDTETSAGQARLGDHAFEDLTDRQNDEVSSEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCT1</accession>
    <name>F9XCT1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catechol 1,2-dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_43103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851936.1">
        <property type="nucleotide sequence ID" value="XM_003851888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCT1"/>
    <dbReference type="STRING" id="336722.F9XCT1"/>
    <dbReference type="GeneID" id="13401294"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43103"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.150"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="F9XCT1"/>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="133"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="311" mass="34498" checksum="401985C045AE0448" modified="2011-10-19" version="1">MASETNGNSGAPIEEEMGKEWTEKIIKSMGPKTDPRMREVMGSLIRHLHDFAREVDLTFDEWVKGVDMINWAGKMSNERRNEGGLMCDVIGLESLVDYITYKKAAASGDATASAILGPFRRLDRPTRDFGSTITFDTPKDGEVAWMHGIVTDAKTGQPLKGAEVEVWQASTNGLYEQQDENQVEHNLAGKFFTTDKGEYAFYCLRPTPYPVPGDGPAGEMLRLMDRHPYRPAHIHLIVSIDGYKSITTQIFDSESKYLEDDSVFAVKDGLVVKFVPRKDDPNAQVELNYDVALAPLGEKGASSAPEAHSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCT9</accession>
    <name>F9XCT9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_93729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851935.1">
        <property type="nucleotide sequence ID" value="XM_003851887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCT9"/>
    <dbReference type="GeneID" id="13401377"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93729"/>
    <dbReference type="HOGENOM" id="CLU_1379114_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCT9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="198" mass="20859" checksum="CDEF09FA52AA34AD" modified="2011-10-19" version="1">MRSIVRESALLRFAVAAQGRRRRGVEVGDMFEDTGGKESLGEKRQSTTDHVEQYRIAEVMQNTLDSTAMVVVIPRAGVWRPCRTVASAWMMLGGGAEGGGVKGGGLSLNDVEGGVVEGGSVEGGGVASGGVDGSAVIRAAAQTPQRTAMYRWRRCIGSGGVDQNDGVDIINAAKGKTQAAWRVMMHAFSFQFNAEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCZ1</accession>
    <name>F9XCZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_72927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851909.1">
        <property type="nucleotide sequence ID" value="XM_003851861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCZ1"/>
    <dbReference type="FunCoup" id="F9XCZ1">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCZ1"/>
    <dbReference type="GeneID" id="13393686"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72927"/>
    <dbReference type="eggNOG" id="ENOG502SBJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086706_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCZ1"/>
    <dbReference type="OMA" id="HINEKAQ"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26447" checksum="CBF096CB3942674F" modified="2011-10-19" version="1">MRDDTVRHKKIVGVVVNSGKMDKTVTVRINGQKWNTRIRKMFPDHIQHLVHDPNNSLVTGDVVELHRLKVSRKVEHVVASIVSPFGTPIESRPPIPTADERLAAYKEYRFKKLQRRELRVKAAEGKAEAIRALKKKGLNPGAGVEEGVGQLENAEYGDGQTKTPSEGAILGEKGQKLPEGVLPGGMREVGKIDDWSAEKKAEYRRLRAEESRNLSEAKEKEAELNEQDLETRSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA0</accession>
    <name>F9XDA0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_104853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851478.1">
        <property type="nucleotide sequence ID" value="XM_003851430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDA0"/>
    <dbReference type="FunCoup" id="F9XDA0">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDA0"/>
    <dbReference type="GeneID" id="13393635"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104853"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.313"/>
    <dbReference type="eggNOG" id="KOG3494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171977_3_0_1"/>
    <dbReference type="InParanoid" id="F9XDA0"/>
    <dbReference type="OMA" id="IKHKYEV"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="64" mass="7152" checksum="6FBC8A7B9C73DB15" modified="2011-10-19" version="1">MAGILGGVYNALVKRNAVFLSVIFAGTYATSLAFDTGANLVWDQINRGRQWKDIKKRYIEADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEL4</accession>
    <name>F9XEL4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851671.1">
        <property type="nucleotide sequence ID" value="XM_003851623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEL4"/>
    <dbReference type="GeneID" id="13401882"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43593"/>
    <dbReference type="eggNOG" id="ENOG502S37A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_1"/>
    <dbReference type="InParanoid" id="F9XEL4"/>
    <dbReference type="OMA" id="YGVQKLG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="212" mass="23974" checksum="06EF9DBC51382E72" modified="2011-10-19" version="1">MSSHTGLLTTTPRLNLSYLESGNDTHCDFIVTLFNTPEFIASNGGNATSIVTREAARQYIEKRFEGEYVRNGFGSYLLSLRRPSPTSEERDGKEEVEEEVYIGTISLNRGPPTPENPTVPDLGFAILPAFMRQGFAIEASRGMLEYAERELGVKEVVGLCAVGNRASNGVFEKLGWRDRVRKSKCRRLSHRRLRDFVYFDVFMMLADFVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFI8</accession>
    <name>F9XFI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_45561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850943.1">
        <property type="nucleotide sequence ID" value="XM_003850895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFI8"/>
    <dbReference type="GeneID" id="13397676"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45561"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="F9XFI8"/>
    <dbReference type="OMA" id="SQTDHVD"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33795" checksum="DF34263A82509CD9" modified="2011-10-19" version="1">MAPGQPQNRFRVDGLVAVITGGGTGLGRYAALALDAQGAAAVYIIGRRRDALDECARLGINGSIRPLVGDITNSDSLKAITEQILTERGFVNFVLANAGIAGPVHRRGDGTVADFAATCIASSAEDFTSTFDVQTTAVFFTAAVFLPLLHAGNQRQNVPQDAQILITSSKESYSRQLGHSFAYSTSKAAVNHLAKMLARTFAQQHFRIRVNVVAPGFFPSEMTQPLTNSLPAYEDRHGAFSGAFRLPEDRNPSERTGSEDDFAAAILFFASPAGAYLNGTELLLVCGNDMLYRRGKLLTYALRRMVGRTSSRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFK6</accession>
    <name>F9XFK6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_29244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850669.1">
        <property type="nucleotide sequence ID" value="XM_003850621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFK6"/>
    <dbReference type="FunCoup" id="F9XFK6">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFK6"/>
    <dbReference type="GeneID" id="13397932"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29244"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_5_2_1"/>
    <dbReference type="InParanoid" id="F9XFK6"/>
    <dbReference type="OMA" id="FLQHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="95" mass="10599" checksum="92C574149CF82A9E" modified="2011-10-19" version="1" fragment="single">FHVDFWGPASNFGIPIAAVMDVKKDPEIISGRMTAALCGYSGVFMRYAFAVTPANYLLFGCHLVNFSAQATQGYRFVNHWYMGGREKALENKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFL8</accession>
    <name>F9XFL8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPR-like GPCR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_100730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851187.1">
        <property type="nucleotide sequence ID" value="XM_003851139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFL8"/>
    <dbReference type="FunCoup" id="F9XFL8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFL8"/>
    <dbReference type="GeneID" id="13397927"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100730"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029962_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFL8"/>
    <dbReference type="OMA" id="SRWTYIL"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54154" checksum="6B8F1A3B33B6D30B" modified="2011-10-19" version="1">MTQTTYCTRTTSATATSARQRRRHSSYNPRSWSSERENAQIAMDGFLSDLGRRLEMLETYGHLKLDEGVKSVHETLRHVHDRCLHVSDDILDAGRRRSKVLVDTLESHYRDALTKKDTLEQKVQEGVKMLEYSLAALEQRAYHMRKAGLTATAHGMIDSSIAYMETGAFKASEIVSEGAEAARRAKEALKAKVDAAIVHARQHGLISYEMLPEPWRVNPHIKNGYRFSETKLDCIRSCFTISNETFNIWSHALGLVIVLALAFYVYPKTPAFTSATRFDIFIAGCFFFAACKCLVCSTMWHAMSSISNQTLMERFACVDYTGISLLVAASIATTEYTAFYCEPTSRWIYLSTTLVLGIAGVILPWNPTFNRADMSWARVGFYVTLAATGFVPVAQLTYQRGLAATLYFYAPIVKSIAVYLGGAILYAAKVPERFLPGWFDYAGGSHNIWHMAVLGGIIFHYYAMQSFFGEAFRRAEYGCSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFS8</accession>
    <name>F9XFS8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_73993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851155.1">
        <property type="nucleotide sequence ID" value="XM_003851107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFS8"/>
    <dbReference type="STRING" id="336722.F9XFS8"/>
    <dbReference type="GeneID" id="13397442"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73993"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFS8"/>
    <dbReference type="OMA" id="VEITRCV"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="291" mass="31774" checksum="B7DE139853D7DA44" modified="2011-10-19" version="1">MPSFDSAKAYAAQETTFFDDGREIELLHYIYSRSDVESSLRNNPTAILAAIDEFARTKKYLMNVGEDKGKIVTDLIAEVKPKVMVELGGYIGYSTLLFASTVKNNGGTHYFSLERNPEFGAVIGSLIALAGLSSFVTISIGSSDASLARLHKSGDLSKIDMMFLDHYKPAYTSDLKLCEELGLVGVGSVLAADNVVKPGNPPYLEYVRSSVAEKKKKAAQEASEDGKDGKAPDERFADRAAKQYANRVAEEKVGVSKGRPELVYESRLVESFEPTGEPVSYILLFSDSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFS9</accession>
    <name>F9XFS9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_44596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850704.1">
        <property type="nucleotide sequence ID" value="XM_003850656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFS9"/>
    <dbReference type="STRING" id="336722.F9XFS9"/>
    <dbReference type="GeneID" id="13397894"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44596"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_24_0_1"/>
    <dbReference type="InParanoid" id="F9XFS9"/>
    <dbReference type="OMA" id="YYDNVFT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
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    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="613"/>
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            <begin position="897"/>
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            <begin position="8"/>
            <end position="19"/>
        </location>
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    </feature>
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        </location>
    </feature>
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            <end position="188"/>
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            <begin position="198"/>
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        <location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85680.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1107" mass="119494" checksum="EAFD085CE831ADD5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG29</accession>
    <name>F9XG29_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
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    </protein>
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        <name evidence="10" type="ORF">MYCGRDRAFT_74120</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 115943 / IPO323</strain>
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    </reference>
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        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="525" mass="56247" checksum="8DFF9F52C8C91CF3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG31</accession>
    <name>F9XG31_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
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    </protein>
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        <name evidence="16" type="ORF">MYCGRDRAFT_110230</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851093.1">
        <property type="nucleotide sequence ID" value="XM_003851045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG31"/>
    <dbReference type="FunCoup" id="F9XG31">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG31"/>
    <dbReference type="GeneID" id="13397833"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110230"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.449"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="InParanoid" id="F9XG31"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="490" mass="53378" checksum="FE0218D089DDCE21" modified="2011-10-19" version="1">MCPTPDDAPATNGHANGHSNGVNGTNGTHDGYQAIKTNQDSRPQSSNPYAPVQDFLSNVSNFKIIESTLREGEQFANAFFDTETKIKIARALDEFGVDYIELTSPAASEQSRLDCEAICKLGLKAKILTHVRCNMSDAKMAVATGVDGVDVVIGTSSHLMQHSHGKDMTYIKNTAIEVIEYVKSQGKEIRFSSEDSFRSDLVDLLTIYSAVDKVGVNRVGIADTVGCATPRQVYDLVRTLRGVVSCDIETHFHDDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMIVANPAYVKGKYKLEKIKEIEDLVAEAVEINVPFNNPITGFCAFTHKAGIHAKAILNNPSTYEIINPQDFGMSRYVHFASRLTGWNAIKSRAEQLGFNMTDAQIKSVTLKIKALADVRPLAIDDADSIIKTFHFNLSADKEKPLLEMSTEEQKKFAKAEAELKGEKEKRELDEQADAEAEVPVAKKTKTAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH88</accession>
    <name>F9XH88_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849988.1">
        <property type="nucleotide sequence ID" value="XM_003849940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH88"/>
    <dbReference type="GeneID" id="13395011"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95079"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.270"/>
    <dbReference type="HOGENOM" id="CLU_909753_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH88"/>
    <dbReference type="OrthoDB" id="5383296at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34038" checksum="A00D512454C921AD" modified="2011-10-19" version="1">MSSSTAYGCTQCSFATPSLTAINTHINTSNNEKRLWRCPGCASYFCLATNLKGHFPLCQKFYTWRTTMKWGRDLDKNSRVQSACDIAEKRAGATAESTFGPQKASQTVAAPTPTPSKRALPKRVPPKKTYDNGQQQISKRRKGAAEEEQPDEDPAQSTEAQESPPKKRLCRSRETTMASPSAKSLEREATSSGNASSGNSEVGHQHSWQESMDDGPVLEFSGEEYEGFDLGTGTSTSDGFGNPPDNPFHDPEAEFLPALTINTYDFRHGLLGIVTDEDRREEEDIERTIREINERWRAFNEGLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHA6</accession>
    <name>F9XHA6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850178.1">
        <property type="nucleotide sequence ID" value="XM_003850130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHA6"/>
    <dbReference type="GeneID" id="13394580"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105604"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.702"/>
    <dbReference type="HOGENOM" id="CLU_2706689_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHA6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="73" mass="8543" checksum="1A689E55B61AA73C" modified="2011-10-19" version="1">MMFEDLFADYIDIPSSPRRRRNDMIPPSASEKPRPSITSWDEFSRPLLKQFNRRGLLPAEQRYLLDESSLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP5</accession>
    <name>F9XHP5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_74768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850037.1">
        <property type="nucleotide sequence ID" value="XM_003849989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHP5"/>
    <dbReference type="GeneID" id="13394238"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74768"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_1_1"/>
    <dbReference type="InParanoid" id="F9XHP5"/>
    <dbReference type="OMA" id="VKISICC"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="33443" checksum="C13516F2B688D9B5" modified="2011-10-19" version="1">MILFVIPGSALGIVLVNTGLGSSIWTISFENITNILHIYYFEGTMYLTGLSFIRISMLLTYLRIFPGAVFRQMAFISIGLNVVCAVVFFLLSTFQCVPVSYSWHRWDGEHEGHCYNINLQIRVAAIVNILLDVAAVVLPLPQLWKMKLNTPKTLLVFLMFAIGLLVPIVSVIRLQTLLQFGNAMNVTYVYARVGYWSSAEQHLAVLCACMPAIRNLIRRFWKRSTTVTHASGSTDSSGNIANSNDTMMEAGSWPREERHSIPLKDIHNDEDRRYDRKASHTASPGSFWVHALETASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP6</accession>
    <name>F9XHP6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_47042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850380.1">
        <property type="nucleotide sequence ID" value="XM_003850332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHP6"/>
    <dbReference type="FunCoup" id="F9XHP6">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHP6"/>
    <dbReference type="GeneID" id="13394239"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47042"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="F9XHP6"/>
    <dbReference type="OMA" id="QDSKCEQ"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903329">
        <property type="term" value="P:regulation of iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="103"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="44097" checksum="AA9E95E8DF5AFA00" modified="2011-10-19" version="1">MGSVRNGSDATAAKKKEEPAVSRRFWVEENGEHFHHLKGAKRQDKLTDIFRDLMLGKKKDHHDEQPLSLMSTWVDQIKSEKDKLAKEKKDGPNAAASLVQKYGKCQEIVGRGAFGIVRIAHKADPNNSKQEQLYAVKEFRRRPQEDSKKYSKRLNSEFCISSSLRHPNVIHTLDLLEDAKGDYCEVMEFCAGGDLYSLVLANGKLDVLEADCYFAQLMRGVEYIHEMGVAHRDLKPENLLLTTHGALKITDFGNGECFRMAWETEPHMTAGVCGSAPYIAPEEYTDKEFDPRAVDVWACGVIYMAMRTGRHLWRVAKKDEDEFYENYIRGRKSEEGYAPIETLHRARCRNVIYSILDPNASRRISAHQVLNSEWGKGIKLCKAGEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHS9</accession>
    <name>F9XHS9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85523.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511793_0_0_1"/>
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    <dbReference type="OMA" id="NACNIRD"/>
    <dbReference type="OrthoDB" id="3622765at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19437" checksum="BFBE2C69930E436E" modified="2011-10-19" version="1">MQAEGSSPGLSSYGSPSTAHRPSISDPSTSPSTCTTYSESAEQLIVLKLDGVVRDMITAVNERNFSSARPPWSTNMSPTARVVPGNLLSAEEMDRQGYLDWLNKITAARPHFRQIITDLMIEVKHGRSAEVIAQKETHGSPPGLIKPSIVSMEFRLVEERWLCTSIRSVHGIGSMING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI67</accession>
    <name>F9XI67_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AvrStb6</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_87205</name>
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    <organism evidence="2 3">
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI67"/>
    <dbReference type="GeneID" id="13394846"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87205"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.451"/>
    <dbReference type="HOGENOM" id="CLU_3034149_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI67"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390638" description="AvrStb6" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="5566" checksum="5E8CE4F49326F7E2" modified="2011-10-19" version="1">MKLSINFICLMAATFFAGQVSAQCKPRGFCCGGDPAEVCGSCCSGLFCSGGSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIW3</accession>
    <name>F9XIW3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_75629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIW3"/>
    <dbReference type="FunCoup" id="F9XIW3">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIW3"/>
    <dbReference type="GeneID" id="13402475"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75629"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.368"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIW3"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="242"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="714" mass="78760" checksum="B2CAC1DE1527FC40" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIZ3</accession>
    <name>F9XIZ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_95525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849284.1">
        <property type="nucleotide sequence ID" value="XM_003849236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIZ3"/>
    <dbReference type="GeneID" id="13402629"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95525"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.60"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="InParanoid" id="F9XIZ3"/>
    <dbReference type="OMA" id="FIARACY"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56180" checksum="04D2A6442559E62F" modified="2011-10-19" version="1">MASPLLPLKPHLGSLDLESLSPTTSAASSLQPSRKRPSRAQPTTIDPDQRSGPIATRRQEIQRQYRLFWSTILAYTGQLFIVLSIAEMSSMVPLGGGQYRFVSAFAPPKFERMLSYITGWICSVGWQTRFTAHCYIIANMGQALIDLQARPTGTGTWFFHLTVIAVAILLSCFNAFAAGHLSIAEGVFAICHVFVLVPILASLWVLADKGDFHYIFFKLTDNGGGWPYTGLSACVGQLTSMFIMLGSDAMVYISEEVEEAEFIVPSSMVWSYVANLPMTFALLVTYIYNVGDLREVVRSPHPLVHVFETMLDSRNATIAFSVIVMGLLIMIAVSTMVATSRHLFSFGRDRALLFAPFISHVHPSLKVPLNAILLTLFTTSIISLCTMGTVSTLHTILGLSTSCFMASYSVSIGCLIRKRWIGEELPTCRWSLGRAGLWVNVLGWMYAVWALFWSFWPTRYAIQPSNANWAIVFFGWTVVAASALFLGAARRERMGRRGTMGRRGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJA9</accession>
    <name>F9XJA9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_95809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849660.1">
        <property type="nucleotide sequence ID" value="XM_003849612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJA9"/>
    <dbReference type="FunCoup" id="F9XJA9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="GeneID" id="13402457"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95809"/>
    <dbReference type="eggNOG" id="ENOG502QSZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJA9"/>
    <dbReference type="OMA" id="AHGSYGV"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="97"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="495" mass="52938" checksum="17AF3FC9DD9C99F8" modified="2011-10-19" version="1">MPSTKVTRINSAGPSIEELDSIELADHGNLSGKSSYDVHVTPTGLQTPEEAYTPCYSTERLAKTPNELECSQPPTPRQATATGVLPSFFYPSMNKWRVLAACLIYFSNGMSDAAPGALIPYIEKGYHIGYAIVSLIWVANAVGFISAAFITDTINGRLGRAKTHMMSEALMMVAYAIIVGGPPFPVVVVAFLLMGFGNAINLALNNVFCANLADSTVILGLAHGSYGIGGIVAPLIATAMVSNGIFWARYYLITLGLRVLCFAFAGWSFWNYEKEGTTQFANSLQQMASRQAAEELGAPSAIKLLGRALKNKTTIIGALFIFAYQGAEVSESGWFISYLIDYRNGDPAKVGYVTSGFWAGITLGRFTLTHLAPIIGEKRFVYILGAGSMAFQVMAWTIPNIIGNAVAVSILGLLLGPVYPCAQTVFTKLLPGNLQMIAISFIASAGSSGGAVVPFLTGLIAQSAGTFVLHPICIGFFALMLVCWTILPKVQKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJK9</accession>
    <name>F9XJK9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_75752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849642.1">
        <property type="nucleotide sequence ID" value="XM_003849594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJK9"/>
    <dbReference type="FunCoup" id="F9XJK9">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJK9"/>
    <dbReference type="GeneID" id="13402439"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75752"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="InParanoid" id="F9XJK9"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="708" mass="78031" checksum="4A250CA44ADEF736" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJU4</accession>
    <name>F9XJU4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_48216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849272.1">
        <property type="nucleotide sequence ID" value="XM_003849224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJU4"/>
    <dbReference type="STRING" id="336722.F9XJU4"/>
    <dbReference type="GeneID" id="13402635"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48216"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.40"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJU4"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="237" mass="26674" checksum="CA179C6BC23944B3" modified="2011-10-19" version="1">MRSALLFEQKVEEMKPSKSDINWVIMDYLVSEGYPGAAAKFAQETNISQPFDTDGIRDRVQIRSAIHAGKIDEAIDLINELDPQILDTDHILHFDLLQLQLIEIIRSILNKPDGGNPQSSEFRPALEFATEQLSPRAPTDQKYQQALERTMALMIFPPDKMTAEFKVLLDLKLRETVADSVNEAILNSKGQRPEAKIRQLVRARAWAEMQAREAKVQLPETLPIGLDGPVDGDPMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJV8</accession>
    <name>F9XJV8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849753.1">
        <property type="nucleotide sequence ID" value="XM_003849705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJV8"/>
    <dbReference type="GeneID" id="13399059"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95665"/>
    <dbReference type="HOGENOM" id="CLU_2279704_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJV8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391489" evidence="2">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="10605" checksum="BB019D3BA8FD3707" modified="2011-10-19" version="1">MQINLIFLTSLAALLLPGQVLADSCQLEQCPLTAQCTCTRPHKGPSQAGPSLWHGRCGQDRSSIPTGGVESQKKDGGGIAAEVLSVGRRSGRETETVGMGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJZ8</accession>
    <name>F9XJZ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_48057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849732.1">
        <property type="nucleotide sequence ID" value="XM_003849684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJZ8"/>
    <dbReference type="STRING" id="336722.F9XJZ8"/>
    <dbReference type="GeneID" id="13399078"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48057"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.272"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="InParanoid" id="F9XJZ8"/>
    <dbReference type="OMA" id="GRMTLCG"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="127"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="44725" checksum="5E583F4ECC2566D8" modified="2011-10-19" version="1">MSTATNPPILIIGAGLTGLILSHALRHISIPHLIYDAESPTTHRTRLREWNMAVHWSIPLLQELLPKELFDRFVAESAVDPSLDPTKAPFNGARIFDGYEGGCLKELEEEGGVVRVSRRKMRGWLLEGVDVKFDHKLESITYNDDDTVTAHFTNNTSSTGRLLVGADGPRSIIRSLLFDNSPSALTAPMSNSISISSVFSYPTPELNKQIRDSTHPTFSMMVHPEIFLFISMQDVPDPNDPATWVFYFFACWRGEPPSSTPTSEELRDLIVAKSKDLHEPYRSVIAHLPPDAVFTPLTLATWTAEPWPTHGGRITLAGDAAHPMLPFRGQGLNNAIQDVANLVAGLEMVEQGELGLGDMVEGYSGEVARRGAEATSMSVKSAEMTMEYWSFKESPMMKMGMRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKK0</accession>
    <name>F9XKK0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_96008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848745.1">
        <property type="nucleotide sequence ID" value="XM_003848697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKK0"/>
    <dbReference type="STRING" id="336722.F9XKK0"/>
    <dbReference type="GeneID" id="13398793"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96008"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.15"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="InParanoid" id="F9XKK0"/>
    <dbReference type="OMA" id="VRFLFFD"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="293" mass="31469" checksum="2FB86C8763A742BA" modified="2011-10-19" version="1">MNHDPQTPAIVSLVAGGFAGAVEAAATYPFEFAKTRVQLREQKGVPTPKNPFKVVFGVYTTEGIAALYKGCLPLVIGSVGKDGIRFLSFDTIKNTFKDPETGTLSPLRSMLAGMASGVVASLTAVTPTERIKTALIDDARNERRFTSATHCVKTILRDHGILGLYRGLAGTTLKQAGATAFRMGTYNILKDFEKTRDIPQTTLTNFANGSVAGIVTTLATQPFDTIKTRCQSSKGASTVEAWKSIIADYGVKGFWKGTTMRLGRTVFSGGILFTTYEWAAAILSPLIVGKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKU8</accession>
    <name>F9XKU8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_48782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848988.1">
        <property type="nucleotide sequence ID" value="XM_003848940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKU8"/>
    <dbReference type="GeneID" id="13398308"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48782"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.524"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKU8"/>
    <dbReference type="OMA" id="WHVYNEL"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="406" mass="45602" checksum="E2B04A16586DC9AD" modified="2011-10-19" version="1">MGSFEVLTQPTIGYSPDYDQYLARVQHRQQTETLPTTLPEGFPAQLKSDLVWDGSDIGSKYNWTYELSTNELEEIEAALSHFKALNIPLGHVSQDTFPLPNLHSALRKISDELHNGRGFKVLRGLPVTKHTREENIIIYAGVSSHIAPIRGRQDHQHDGKPADVVLAHIKDLSRIVDASKIGAPAYTTDKQVFHTDVGDVIALHCLDTAAEGGQSKLSSSWTVYNEIAKSRPDLIRTLAEPWAAENFSGKGPRYSLRPLLHYTPRTATSPERMIIQYARRTFTGYMGLPRSSDIPPITEAQAEALDTLHFLAEKHAVTLDFQQGDVQYVNNLSIFHARNAFKDTPEQQRHLVRLWLRDPENAWQTPEGLAQRWADIYDGVTPENSVFPLEPRIRTASSGGKEQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL39</accession>
    <name>F9XL39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849127.1">
        <property type="nucleotide sequence ID" value="XM_003849079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL39"/>
    <dbReference type="STRING" id="336722.F9XL39"/>
    <dbReference type="GeneID" id="13398045"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111045"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.281"/>
    <dbReference type="eggNOG" id="ENOG502SHP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_0_1"/>
    <dbReference type="InParanoid" id="F9XL39"/>
    <dbReference type="OMA" id="TDHYFMG"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="80"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="503" mass="57254" checksum="6EFDEA675EDBA285" modified="2011-10-19" version="1">MGADATDAQDKDLAMVTEYAISLSTADEMELEELRSPEEEGLLTGHLDAPRTKARRLLSSLSITTIFNYPEAGVQLRPTAWLDGLRGLAAFEVFLFHYLDDWPVDKRAVWGPSNENGHKPGVLYMPLVRSLLFSGDTAVCMFFAISGYVLSHRMLVMISDRKQEGLLPVLSSSLFRRGTRLYLPVLVQTFVLMLAIRLLGFPKPSVWPSAPTFLAEVQNWFVSFIHLLMPLRFPERFEQLSNRYDGGISWTIPLEMYGSLQIYLAILALAYVSSTKARRLLLAIWIVVSAMRDDWISGQFLLGLSFADYQIQRQRDPPAPSSWQKWRPAFLAVLFALGFYTAGMPSVQYEHEEYGAAMMKTRPGFTWLNLPQPFTDLYMDFQVDRMQRCLAAWACLIAIGELPFLRKCCERRFVQYLGRISFGLYLCHIWVRPCLNPLAHLTCGIFGIDSENKTGSLVPLAWVLYFIPSAAINFIVAGLFERFLDRPSIQAGKKLEKFFLSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM34</accession>
    <name>F9XM34_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848542.1">
        <property type="nucleotide sequence ID" value="XM_003848494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM34"/>
    <dbReference type="GeneID" id="13396488"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106205"/>
    <dbReference type="HOGENOM" id="CLU_2795896_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM34"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="68" mass="7529" checksum="CFED7D098CD9ADC8" modified="2011-10-19" version="1">MDHRTDSKMRVTDKGSTSACQVVTAMDEWWGCTCQKLPLTNVNDVLMTQSARLAHARSVLFDLAVCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMP9</accession>
    <name>F9XMP9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_76723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848309.1">
        <property type="nucleotide sequence ID" value="XM_003848261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMP9"/>
    <dbReference type="FunCoup" id="F9XMP9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMP9"/>
    <dbReference type="GeneID" id="13396550"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76723"/>
    <dbReference type="eggNOG" id="ENOG502QR9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="InParanoid" id="F9XMP9"/>
    <dbReference type="OMA" id="QQQWEMY"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
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            <begin position="32"/>
            <end position="55"/>
        </location>
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            <end position="125"/>
        </location>
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            <end position="156"/>
        </location>
    </feature>
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            <end position="190"/>
        </location>
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            <end position="247"/>
        </location>
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            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
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            <begin position="327"/>
            <end position="352"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="514"/>
        </location>
    </feature>
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            <end position="23"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="537" mass="58704" checksum="2A4140FBAA8D9423" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNK5</accession>
    <name>F9XNK5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_106319</name>
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    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="F9XNK5"/>
    <dbReference type="OMA" id="EFDKFTD"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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            <end position="240"/>
        </location>
    </feature>
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            <end position="151"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="240" mass="26411" checksum="EB8BCEACEA0EC492" modified="2011-10-19" version="1">MSGYNPRRAPNVSQYLQNLNTIPSPQDHLAQQAELSLADDGLDFLTNAEFFDFDQFNPNAAGFPQNDIVAKPETPFQFGDFGAFPPTAVTSPSTISSPHNGLQGAYPPQPHHFPGATTPSTGDKRKASIAGVPAPEHLEESSRVAAEEDKRRRNTAASARFRVKKKQREQALEKQTKDMADKVSALEGKVQQLEMENKWLKELITEKSDTKTLEAALEARMKKETTERSSGNRTDGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848065.1">
        <property type="nucleotide sequence ID" value="XM_003848017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP80"/>
    <dbReference type="STRING" id="336722.F9XP80"/>
    <dbReference type="GeneID" id="13402101"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111557"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.405"/>
    <dbReference type="eggNOG" id="ENOG502S5YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016272_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP80"/>
    <dbReference type="OMA" id="TRHYAKW"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="686" mass="74062" checksum="C889085D7A670A73" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPB8</accession>
    <name>F9XPB8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MgBGL13</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_77647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848049.1">
        <property type="nucleotide sequence ID" value="XM_003848001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPB8"/>
    <dbReference type="STRING" id="336722.F9XPB8"/>
    <dbReference type="GeneID" id="13402112"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77647"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.449"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="F9XPB8"/>
    <dbReference type="OMA" id="YWEDRIS"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="398"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="836" mass="90713" checksum="B8F6B755A3E5BACB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPE6</accession>
    <name>F9XPE6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_22021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847853.1">
        <property type="nucleotide sequence ID" value="XM_003847805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPE6"/>
    <dbReference type="GeneID" id="13401493"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22021"/>
    <dbReference type="eggNOG" id="ENOG502QSXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011027_0_2_1"/>
    <dbReference type="InParanoid" id="F9XPE6"/>
    <dbReference type="OMA" id="HQFANSY"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="548" mass="60509" checksum="DAAE223EC964B87D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ36</accession>
    <name>F9XQ36_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pali pH response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pali</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_101873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847748.1">
        <property type="nucleotide sequence ID" value="XM_003847700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ36"/>
    <dbReference type="STRING" id="336722.F9XQ36"/>
    <dbReference type="GeneID" id="13401013"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101873"/>
    <dbReference type="eggNOG" id="ENOG502S1J0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XQ36"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395606" evidence="7">
        <location>
            <begin position="32"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP82724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="543" mass="57416" checksum="7310F9C726383A1F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQB8</accession>
    <name>F9XQB8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgRho3</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_64768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847638.1">
        <property type="nucleotide sequence ID" value="XM_003847590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQB8"/>
    <dbReference type="FunCoup" id="F9XQB8">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQB8"/>
    <dbReference type="GeneID" id="13401338"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64768"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="F9XQB8"/>
    <dbReference type="OMA" id="THTIMLC"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="21271" checksum="9477A8D7549422E6" modified="2011-10-19" version="1" fragment="single">MPALCGGSKTVQRKLVLLGDGACGKTSLLNVFTRGYFPTVYEPTVFENYVHDIFIDNVHVELSLWDTAGQEEFDRLRSLSYDDTHAIMLCFSVDSPDSLENVESKWVGEIAENCPDVRLVLVALKCDLREVGKDDDEGGAEGGVKRECIDYKQGLAVAEKIKALRYLECSAMKNRGVNEAFTEAARVALQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQF4</accession>
    <name>F9XQF4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847657.1">
        <property type="nucleotide sequence ID" value="XM_003847609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQF4"/>
    <dbReference type="FunCoup" id="F9XQF4">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQF4"/>
    <dbReference type="GeneID" id="13401060"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106565"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.337"/>
    <dbReference type="eggNOG" id="KOG4090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093520_0_1_1"/>
    <dbReference type="InParanoid" id="F9XQF4"/>
    <dbReference type="OMA" id="CDADARN"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018648">
        <property type="entry name" value="DUF2076"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16053" checksum="8A278E1E405B7629" modified="2011-10-19" version="1">MPRQSRGPASAPRRPTVQQRPAPPTQARPASTSAAQPQRPQAQAPPQAQSGGSGLFGQMASTAAGVAVGSSIGHAVGGWFGGGSSSAQQEQAAPVDQQDNGMYQSSAMSQSNAAQGACANDVNNFRQCMDQNQGSLTICGWYLDQLKACQQAASQY</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRV3"/>
    <dbReference type="GeneID" id="13399249"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97945"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.33"/>
    <dbReference type="HOGENOM" id="CLU_1373202_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRV3"/>
    <dbReference type="OrthoDB" id="10374027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="212" mass="23888" checksum="50CCE58792923A30" modified="2011-10-19" version="1">MPRLVPPAELPASLVDAFAELDMSNSKNNSSHSHPHVKREEQPDQWYNDTRHSKSPIHVVKEDPVNVVKEDPINVVKKDPVNVAHLSSIKKEHSKSPSFIKEKPANIINEQDLIYSSSSSFSPKVGWYFAHRLDLDRARKLGSVMLPDGTKALQLRAEDVAALRQAGWMALRGIAIVYYDNGMQQDVVKKEEMEGEGVDLEAMGERLQRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW47</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857679.1">
        <property type="nucleotide sequence ID" value="XM_003857631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW47"/>
    <dbReference type="STRING" id="336722.F9WW47"/>
    <dbReference type="GeneID" id="13403913"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88841"/>
    <dbReference type="eggNOG" id="ENOG502SKIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014596_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW47"/>
    <dbReference type="OMA" id="REGWTQV"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="591"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="717" mass="79328" checksum="0A5E2995856CA25B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW77</accession>
    <name>F9WW77_ZYMTI</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_106870</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP92639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9WW77"/>
    <dbReference type="GeneID" id="13403927"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106870"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.339"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
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    <dbReference type="UniPathway" id="UPA00659"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="30797" checksum="52516E32D92F2EAF" modified="2011-10-19" version="1">MSASSLKYDFFNVSIPVEYVAVVEVDRVKKLNAFTQQMFTDLGAIFRRLSVDPDVRVIILTGAGEKAFTAGLDITAASQGALTGGGMPGAEKDTARKAWDLRRHIKEIQEPVSDVEKCEKPVISVMHGISYGAAIDISTCCDIRICSKDTIFSVREVAIGLAADVGTLTRLPHTQVPMSWIKDICLTARDFGAQEALTMGFVSGVYDSKQAALDRAMVLAKDIAAASPIAVQSTKAVINYSRDHSVADGLDYVAVWNAAMLQTQDVKDALFSKKEKRTPKFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWH8</accession>
    <name>F9WWH8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107136</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856227.1">
        <property type="nucleotide sequence ID" value="XM_003856179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWH8"/>
    <dbReference type="STRING" id="336722.F9WWH8"/>
    <dbReference type="GeneID" id="13394632"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107136"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.854"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWH8"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="550" mass="58756" checksum="D004F86926322521" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX12</accession>
    <name>F9WX12_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_13179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_13179"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Lindquist E."/>
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                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="23041" checksum="61B013FF34E7520A" modified="2011-10-19" version="1">MTSQNTSRLPQVIRRYGEVAEAVNHREMRRSVEEIAHRWKPPPHEEEYRCEGWTHEGAFTKTIYQEALNFFGGSGSCHSPGATEAEVHEQIQISPSLEDLMDFVEEPLIEPPLSADRRKVLLENIKSGLKQQASSLGVDATNLELPEDLDVLYSTVMGINAAGVPAETNFTQLVYAHDERSRPPNEMPYEMFIRRDSYLGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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            <end position="534"/>
        </location>
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        </location>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY81</accession>
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        </submittedName>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
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        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02775"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYL4</accession>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    <dbReference type="AlphaFoldDB" id="F9WYL4"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67350"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1878"/>
    <dbReference type="eggNOG" id="ENOG502SII6">
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    <dbReference type="HOGENOM" id="CLU_025005_3_1_1"/>
    <dbReference type="InParanoid" id="F9WYL4"/>
    <dbReference type="OMA" id="CIPIEVK"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="547" mass="62452" checksum="54C3D2F45CF87079" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0M9</accession>
    <name>F9X0M9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_84186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856678.1">
        <property type="nucleotide sequence ID" value="XM_003856630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0M9"/>
    <dbReference type="GeneID" id="13398084"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84186"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1770"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="InParanoid" id="F9X0M9"/>
    <dbReference type="OMA" id="VFIRTPC"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60996" checksum="08F86FE773120C2C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1F4</accession>
    <name>F9X1F4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857086.1">
        <property type="nucleotide sequence ID" value="XM_003857038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1F4"/>
    <dbReference type="GeneID" id="13398873"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102794"/>
    <dbReference type="HOGENOM" id="CLU_2308298_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1F4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="11300" checksum="EA9C2B1D1BB09575" modified="2011-10-19" version="1">MQQSERIPSSTSRDFYERIHSCGVACLIATNGFVRHVTKDRRPKRHLVFKARVLFVPAHLIDQVRWPGEERVPGPSLVPRNSSRAAGSPRAGPRRFARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1K1</accession>
    <name>F9X1K1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_84295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856780.1">
        <property type="nucleotide sequence ID" value="XM_003856732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1K1"/>
    <dbReference type="STRING" id="336722.F9X1K1"/>
    <dbReference type="GeneID" id="13398530"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84295"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1K1"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF62">
        <property type="entry name" value="LEUPAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
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        <property type="match status" value="1"/>
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        <location>
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            <end position="506"/>
        </location>
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            <begin position="522"/>
            <end position="582"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="339"/>
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        </location>
    </feature>
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            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="647" mass="71577" checksum="312A6C9A527E62BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X294</accession>
    <name>F9X294_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Clp ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_103218</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855544.1">
        <property type="nucleotide sequence ID" value="XM_003855496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Y8"/>
    <dbReference type="STRING" id="336722.F9X2Y8"/>
    <dbReference type="GeneID" id="13399585"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90760"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.592"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9X2Y8"/>
    <dbReference type="OMA" id="GRGSWYM"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72055" checksum="EDDAE395F947E89B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X389</accession>
    <name>F9X389_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68986</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X389"/>
    <dbReference type="STRING" id="336722.F9X389"/>
    <dbReference type="GeneID" id="13400243"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68986"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038278_1_0_1"/>
    <dbReference type="InParanoid" id="F9X389"/>
    <dbReference type="OMA" id="GITWIDN"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="462" mass="51679" checksum="6693F72B8773727B" modified="2011-10-19" version="1">MGAAKRMSNGEPKIVGPHPSTIRVSAPYITQSAVEKRLQPSGLDAQERNIAAAREDQFCLQGVTWLDNVRRALQLPIRTFTTACVYYHKFRLAHPTSEYSWSDAAAASLLTSCKNEDTLKKSKDILAAAYNMKQLSSHEQVGSDDPMFDGPSRAVVGVERLILESGAFDFRSRSPHQVLVKICKSLPPSEDLRSVAQLAWTVLTDLHRTFAPLKQTSATLSLASLEIAVQLSTIASTTKTCSVYPDLRALNISKWYTTRAEVMETLLDALDLYTHHTGATILGPKYSLDDLIRIRLAFNKECSESNLPRHTSIQPPTSPENTNGGPASTLRVANGHPTPVSPPQPDTLQPTQQPASGPFQPEPEGGGTLRFMLNPQRAVDERAEVSRYHVEEWEEYEEEIEVPLERTRLRERERDRRYDDRRGHGGHGHGHRGGRDRRFEERGPPPYEGGGDRRRGPRHDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3B6</accession>
    <name>F9X3B6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855771.1">
        <property type="nucleotide sequence ID" value="XM_003855723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3B6"/>
    <dbReference type="STRING" id="336722.F9X3B6"/>
    <dbReference type="GeneID" id="13395932"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90411"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.129"/>
    <dbReference type="eggNOG" id="ENOG502S65Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906764_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3B6"/>
    <dbReference type="OrthoDB" id="3629107at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395491" description="Phospholipase A2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33619" checksum="8E71B6444AE11CC0" modified="2011-10-19" version="1">MKFLEVLALTVLLSSPATASCVVDPDSKESIFHLVNKDLVPFVKRDNNLEQAEDKTGLPATKEDVPVFHFQKAQNAPQGVYDLILADDDTAKSQFVGRTDDGSLVLTSASTGPSGQRVDGKNVATSIFTVDCKGNVGFSQESKTSSLTARSASSIGAMIAFNYDPQFMDDRLEKEASRRLLTKRDEAYRCPPGQGGHVKPGARDPTINGCGSEKYHHYVPEFNFGPCCDQHDFCFDDCGAPSLSSCNNTFGMCMEYACDSRYSSGIKKLLRAPCRGAARIYLDYVSGSVGVYYFNKYTQERCYCSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3H1</accession>
    <name>F9X3H1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_103141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855659.1">
        <property type="nucleotide sequence ID" value="XM_003855611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3H1"/>
    <dbReference type="FunCoup" id="F9X3H1">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3H1"/>
    <dbReference type="GeneID" id="13403599"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103141"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.359"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X3H1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="211" mass="23251" checksum="EAB75842311C0BF7" modified="2011-10-19" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDNKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKQQTYENVTRWLKELRDHADTNIVIMLVGNKSDLRHLRAVSTDDAKQFASENGLSFIETSALDASNVELAFQQELAEIYRIVSSKALDQGEPSQGPGQGSAIPLGPSNMPADKKSGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V6</accession>
    <name>F9X3V6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_84757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855069.1">
        <property type="nucleotide sequence ID" value="XM_003855021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V6"/>
    <dbReference type="STRING" id="336722.F9X3V6"/>
    <dbReference type="GeneID" id="13400964"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84757"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.850"/>
    <dbReference type="eggNOG" id="ENOG502RBA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_4_1_1"/>
    <dbReference type="InParanoid" id="F9X3V6"/>
    <dbReference type="OMA" id="PHHWLRF"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF38">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33980" checksum="1BBF992BB7C29547" modified="2011-10-19" version="1">MDLRGLTPAPVTPFTESGEVDYDAIQRLGSWLGSIAGVKGLVVLGHAGEGTFLTQDEQLAVIRAFVKSVDDRIPIIAGITGEGTEVAALEAKRAKEAGAKAGLLYPSHGWLRFGYQPGAPQDRYKRVFEVSQLPLILFQYPDNTHATYNLQTMLDISAQPGVFAMKNGVRNMRRWDTEIPVIRKERPGLQILTCHDEYLLHTAFDVDGFLVGYGNIAPEPLIEMIAAGKAQDYKRAREIHDQLLPLTKSVYHRGSHMEGTVALKHALVARGILTHTTVRSPLLPLQEGADKEVHAAVQSANLFKIGAGGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5A3</accession>
    <name>F9X5A3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_92002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854268.1">
        <property type="nucleotide sequence ID" value="XM_003854220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5A3"/>
    <dbReference type="FunCoup" id="F9X5A3">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5A3"/>
    <dbReference type="GeneID" id="13404356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92002"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.877"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5A3"/>
    <dbReference type="OMA" id="WLDTCPV"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="53059" checksum="32959BD43CBAA919" modified="2011-10-19" version="1">MGRELNSLGDDDQPLSQLQANLQAAATSPPGHTTCSPPPSAEEFPLIHQVDNKWQQNAHTPADLEDHDQIICDNLSTTRRIRRLIAFTIFLVVATFYIFSQHVRPSMEEEWAYEQGFLDQTNGTYGVAKAGKHYTDPDLTRMKRLDPALLPGGSGDEAGKRRLVFIGDVHGCKKELLKLLRKVDFNEDLDHLVLVGDTVSKGPDNVGVLDELIRLNATSVRGNHEDRLLVAAKSMLVDGEMETTDDEVEELRSKGSKKDRKLLKKLKPKHLDYMRDMPLMLHIPSLPLASKPTNKWHSPIAEHILVVHAGLVPGVELEKQDPYFVMNMRSINRKTHLPSVLRADKKEKDKKPWFDVWNWYNSRIFKGASMEGFKSTLFELEGEIKSLPDLEPSMWFGDLWKSFFGKKKKHSHFKPQVVIYGHDSHEGLQLNRWSKGLDSACVAGGRLTAMVVDAKGRQEVVSVGCKNYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5C5</accession>
    <name>F9X5C5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_79738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854675.1">
        <property type="nucleotide sequence ID" value="XM_003854627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5C5"/>
    <dbReference type="GeneID" id="13395861"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79738"/>
    <dbReference type="eggNOG" id="ENOG502SZKE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182434_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5C5"/>
    <dbReference type="OMA" id="YETRPGQ"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="69" mass="7174" checksum="E761C3BF65E9822F" modified="2011-10-19" version="1">MSAPNQGRQSPEPERQSDSQTGTQASQPNDQNAGPGGAKPAEQSKETLEKLGSNPGGPLDEEAKKKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5G1</accession>
    <name>F9X5G1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_69248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853633.1">
        <property type="nucleotide sequence ID" value="XM_003853585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5G1"/>
    <dbReference type="FunCoup" id="F9X5G1">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5G1"/>
    <dbReference type="GeneID" id="13395841"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69248"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5G1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="691"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="2"/>
            <end position="3"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="928" mass="104256" checksum="45D1B4D0C7FBC81A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5U7</accession>
    <name>F9X5U7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_70334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854249.1">
        <property type="nucleotide sequence ID" value="XM_003854201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5U7"/>
    <dbReference type="STRING" id="336722.F9X5U7"/>
    <dbReference type="GeneID" id="13404368"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70334"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="InParanoid" id="F9X5U7"/>
    <dbReference type="OMA" id="ENSPHFL"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="372" mass="41558" checksum="30DBC57BBD535221" modified="2011-10-19" version="1">MAGTSQIPVLDLSWAADPDKKPALLQQLRSALFDVGFLYITNHGVQQSTITGLTDLLPALFALPNEEKAALSKLNSPHFLGYSGFAEETTLGKHDLREQFDFATELPVVYDEPGNFTKLYWRLRGGNQWPAESSLPGFQEAFTQYHDAVQALSYSFVHLVEEAFSIPVGTFDHFFGRLPPENTTSTFEHQRRFLPPQHRIKLLRYPPSQGNEGDLGVGAHKDSSGWLTFLYQVGSEPGLEVLSASGDWIAATPIPGSFVVNFGNAFEAATEGAVKATIHRVIAPGPESNVRYSIPFFQGLPLDMTVSEVREYIPEHVRRLRKDSGQVEDGLSAFLDPRWDSLGESQLRKWIRSHKDVALKWYGKEVVNYYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5V1</accession>
    <name>F9X5V1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_39186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854247.1">
        <property type="nucleotide sequence ID" value="XM_003854199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5V1"/>
    <dbReference type="STRING" id="336722.F9X5V1"/>
    <dbReference type="GeneID" id="13404371"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39186"/>
    <dbReference type="HOGENOM" id="CLU_146891_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5V1"/>
    <dbReference type="OMA" id="AEYFTIC"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="164" mass="18161" checksum="8A5C1578925BBDEB" modified="2011-10-19" version="1">MIHYFYFLDYEVGKRGAGLETPAVAADLVSEDDHALAHAKIFAVAEKYQVPGLKELAVGKFKAAMEVHEKHPDFAEVVTTVFATTPETVRDLRDIVSTRLTTNPNLLDSKDIESAVNSVSGLTFELLRQAHKATAALKMSRTNWGPPTTCYRCLRFAKRCGTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6A0</accession>
    <name>F9X6A0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853882.1">
        <property type="nucleotide sequence ID" value="XM_003853834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6A0"/>
    <dbReference type="GeneID" id="13395566"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91789"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.619"/>
    <dbReference type="HOGENOM" id="CLU_1112079_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6A0"/>
    <dbReference type="OrthoDB" id="10363409at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="250" mass="27607" checksum="63D82BC5ABEAA965" modified="2011-10-19" version="1">MDQSPAAPRAPPNTPAQRLGWWPDGVLAEPDTRFTPPYTTLSALANLASLTTLHSSLHSDISSISDLYTALGELYHSLAPLLPSPGQLSGHEHAIPLTNLQALFTVHFSEEGQFDTGILRLPSLEHGPTNFFISQFSDVKESLIHINRAALVHGSVEAYPEVQATMELADEVLDELKERLVTAKFYLEAVDGLNGTAITEGSDSQRYWAVQKRDWDEAVDIMHRIGQRRTGWDVTDADRATIRNRAGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6A6</accession>
    <name>F9X6A6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_103773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6A6"/>
    <dbReference type="FunCoup" id="F9X6A6">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6A6"/>
    <dbReference type="GeneID" id="13395563"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103773"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.624"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_9_0_1"/>
    <dbReference type="InParanoid" id="F9X6A6"/>
    <dbReference type="OMA" id="MHGKDVN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="344" mass="36200" checksum="6F14CF77610BB319" modified="2011-10-19" version="1">MSVDAVTAQMANTSLETSNTEGAAADKPINASQNEAVIASAAEGRRLYIGNLAYATTEGELKEFFKDYLVETTSIPTNPRTTRPVGYAFVDVSTPTEAERAIENLNGKTILDRKVSVQLARKPEPAAAANTEGGENADGTRRRNSTRGRGRGRGRAGRAGRGGRKSGEEGEAATNGDAAAANPLTATTNEAAVATGETGDDKSRPARKQRGPPEDGVPSKTKIMVANLPYDLREERLLEIFADYSPTSAKIALRPIPKFMVRKLQARNEPRKGRGFGFVTLSSEELQQKACADMNGKEIEGREIAVKVAIDSPGKEDEDPTAAAAEGGEAAAAPAAAEAPATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6A9</accession>
    <name>F9X6A9_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854376.1">
        <property type="nucleotide sequence ID" value="XM_003854328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6A9"/>
    <dbReference type="STRING" id="336722.F9X6A9"/>
    <dbReference type="GeneID" id="13404225"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91797"/>
    <dbReference type="HOGENOM" id="CLU_1587807_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6A9"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="168" mass="17685" checksum="9140AA0A7BD46066" modified="2011-10-19" version="1">MSGNDGKTPVLNFITYEPGSKPTNKDPTLRSRVRSHVTRLQHRKEREKRKLAGSAGTLPLQLQHPDEPSAELEDASSTVGAVDSETSSLNSPATAGPSRNSSIGTHQSAGHASRNSSISALRSAGTQTAQLPRPSAAQLVRSGKLAGNVSRQTITSDSNDQMAACSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6N5</accession>
    <name>F9X6N5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_108444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854599.1">
        <property type="nucleotide sequence ID" value="XM_003854551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6N5"/>
    <dbReference type="GeneID" id="13395785"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108444"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="InParanoid" id="F9X6N5"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="684" mass="75846" checksum="486F38D4C2CA7BD3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7F6"/>
    <dbReference type="GeneID" id="13404517"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38880"/>
    <dbReference type="eggNOG" id="ENOG502SQUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030583_1_0_1"/>
    <dbReference type="InParanoid" id="F9X7F6"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
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        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
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        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="93"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="282" mass="29124" checksum="DB67B41AA53070F1" modified="2011-10-19" version="1" fragment="single">SATTQTSTATGLTTSLSTSLTTSLTTSLTTSLTTSLTTTLTTSLTTTILPTTTTTSASITTSTTSASGTTSASALPTPTSCGNQGLAWAEYDTPEVTYTGGYPEFNPAALKRQAPNYSGIVNNIPGYTFDEGTGANGQLTIYDGISIPTSYFAINHQGYIYPDVSGTYTFTSTNGDDVALLWLGSNAYTGWNRANANLEQAFGGSRPTSTPQTYSVELIAGTYYPIRIIGANGAGATSLQITATRPDGTQFLGPNTSGSGLLVQYSCNSALAPPFPAFGQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9X7G0"/>
    <dbReference type="GeneID" id="13404515"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85462"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7G0"/>
    <dbReference type="OMA" id="DMGEDLH"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="27684" checksum="0B08C99EA877E19D" modified="2011-10-19" version="1">MADPFEVRMRFTSQLQHLNASTSSAHKAANYALRHSEFSDDLHSCILEQLERNNMNNRANIMYFLPALCDTAKAQGEIGYIRMMERDILRIIDLVAPDDGSGAANVKVVRKVLGILRERTFLQPQTVVELEECIVGRDSAVRNTPQSMAREAGGMGSGMFNPGIRLDKRQIEQRIEEDRERHKRAREGIWAIAQQQHSMGGLAVDAEFEKLWEDGSVVDDDDYQMAREEAEERRKHLEFDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7J4</accession>
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        <recommendedName>
            <fullName evidence="3">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_70560</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="F9X7J4"/>
    <dbReference type="STRING" id="336722.F9X7J4"/>
    <dbReference type="GeneID" id="13404472"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="219" mass="24738" checksum="2238DE19A7E8CFFF" modified="2011-10-19" version="1" fragment="single">MVPASIQKAKGLTSRAVNSDYPGLLLQPDASPISLEQLAAEIKGIYAGLVMVEAKCMSIDKAQADDLKSHLDPEQWQALIALHRTLLYEHHDFLMATQHPSATEALRGLATKYSMPARMWRHGIHAFLEVLRHRRPASQDYMLSFIYLAYQMMALLLETVPSFTDTWIECLGDLARYRMAIEEEKEAHATWGGVAARWYTLASDRHPAIGRLYHHLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="17"/>
        </location>
    </feature>
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        <location>
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            <end position="180"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87791.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="180" mass="20010" checksum="D290B6613D52C03B" modified="2011-10-19" version="1">MKFSQLSTALLFAPAMAGLLSKRGVQEVPNPGVGDDIPKEAKEKFLSNDVKNLLFTKDAEARDDKEQHHVPKYLFVLMCRTQGFRGECLVFGAAPGQCVNYYDFNTDGKTGKSYDKNITSLSSSYGDVCQFYTDKDCGFDNENSGVSLQYAYNLDISESGNTRPDDYDGSYGHNISSWRC</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-bd_C"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="446"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="552" mass="60841" checksum="CCC5E2A1C78DA042" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X902</accession>
    <name>F9X902_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_92485</name>
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    </evidence>
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        <source>
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    <sequence length="300" mass="33307" checksum="7D79DD3153954404" modified="2011-10-19" version="1">MADSNEASFTSQRARLLNRVNANARAVMEGLWDNIKKPYKPTSPPARPDDEEWKTLVSLQDKFVRWVAERRACKTREAKEELSYKIIMECREDFPKIASREFEEPDLPDSMKPRDPAPTPTPEPEESAQPQAPTLPVADPFVAAPAIRAPGAQTSRLSNSAQPGQLNRAQSSLFPATPTPQNNSPARAHRSGPIILDDDEEDGIKRERDDDYDPTLSPPPPSDAGPTPGPTVGPKDASKPKRKRQRIEDFAMLVRSEDPADLRYLRKRIVNKHEAQLMQIDHQLEKLGARVEGGNEGGGA</sequence>
</entry>
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                <person name="Ben M'barek S."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
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                <person name="Oliver R.P."/>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="157" mass="17848" checksum="95CFBD62DB728960" modified="2011-10-19" version="1" fragment="single">KPIVREPFPNAILDRSPVHGASKSVVLRTCFRVGEAISAGCQSVRTGNNTIIELYARVTSSWREPAPGRKQHFVFKDLYHDRQPHLEGTFELWGQAPLWDLDSKPLLLADTQGTMCRVIARMRRDGQKWRLEVLSIWEASWEDIDFVAGIYAGSVQK</sequence>
</entry>
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    <accession>F9X9W1</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Wiebenga A."/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="453"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="122"/>
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    </feature>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88582.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="811" mass="90122" checksum="7071CF26F657C8B3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Z7</accession>
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        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853324.1">
        <property type="nucleotide sequence ID" value="XM_003853276.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X9Z7">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9Z7"/>
    <dbReference type="GeneID" id="13399992"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109224"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.627"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9Z7"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
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        <property type="entry name" value="PIN_XPG_RAD2"/>
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        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
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        <property type="entry name" value="5-3_exonuclease_C_sf"/>
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        <property type="entry name" value="PIN-like_dom_sf"/>
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        <property type="entry name" value="UIM_dom"/>
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        <property type="entry name" value="XPG-I_dom"/>
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        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
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        <property type="entry name" value="XPG_CS"/>
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        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
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    </dbReference>
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        <property type="entry name" value="XPG_N"/>
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    </dbReference>
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        <property type="entry name" value="XPGRADSUPER"/>
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        <property type="entry name" value="XRODRMPGMNTG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
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    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="983"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="328"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="862"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1253"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1308"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP88300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147797" checksum="13B0B8BF76A3A401" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAB5</accession>
    <name>F9XAB5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_40145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="eggNOG" id="KOG4532">
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    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="697" mass="77407" checksum="E41FC8CF51E3821B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAC2</accession>
    <name>F9XAC2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_71493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853278.1">
        <property type="nucleotide sequence ID" value="XM_003853230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAC2"/>
    <dbReference type="STRING" id="336722.F9XAC2"/>
    <dbReference type="GeneID" id="13399328"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71493"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.708"/>
    <dbReference type="eggNOG" id="ENOG502S0NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_1"/>
    <dbReference type="InParanoid" id="F9XAC2"/>
    <dbReference type="OMA" id="WWSSTYE"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="311" mass="34139" checksum="0115046DD60A6096" modified="2011-10-19" version="1">MGNLAILGASGKLGFATLNALLEHNLIPSTSIIVTSSSTSGAEKLKAAQSAGVQLRSASFDDDSSLISAFEGCDKLFLISSPRISKDFNNAPPGHGREEDHFRALQAAKKAGVKHVYYTSLAFANPSLSEVMTAHERTEEFLTSGQSGMQWTILRQGLYNESWPLYFGHWKLGEDERSEVVVGGDGKVNWTSIADLGLASALILAAPEEEWAGKTVYLSQGKSHSLKDVATMVGRALEREVKLKVVEREEHENFYVEERGMDRPFVEWWSRTYDALRAGECAIEDGTLEKLLATKAVKPKALEDTIREMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAG7</accession>
    <name>F9XAG7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RKIB</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_42258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852580.1">
        <property type="nucleotide sequence ID" value="XM_003852532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAG7"/>
    <dbReference type="STRING" id="336722.F9XAG7"/>
    <dbReference type="GeneID" id="13396902"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42258"/>
    <dbReference type="eggNOG" id="ENOG502S5ZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="InParanoid" id="F9XAG7"/>
    <dbReference type="OMA" id="YPPFCLR"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="17030" checksum="22E7A9705C2D2147" modified="2011-10-19" version="1">MASTSGLVIAMGADEAGCGYKNKIKADLEADPRVAEVIDVGVNESSDKTAYPHPAVDAAKLIAAGKADRGLLICGTGLGVAISANKVPGIRAVTAHDSFSVERAILSNDAQVLCMGERVIGIELARRLVKEWIGYKFDTSSASAQKVEAIMEHERTNFGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAV5</accession>
    <name>F9XAV5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852089.1">
        <property type="nucleotide sequence ID" value="XM_003852041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAV5"/>
    <dbReference type="STRING" id="336722.F9XAV5"/>
    <dbReference type="GeneID" id="13393865"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104394"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.153"/>
    <dbReference type="eggNOG" id="ENOG502SZHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567667_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAV5"/>
    <dbReference type="OMA" id="MWGADKI"/>
    <dbReference type="OrthoDB" id="3649448at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="481" mass="53993" checksum="DC60AD09D108FF2A" modified="2011-10-19" version="1">MAGTGLALTGVMWGTDKVPDHWFENIPILGPKLFKEEKKYKAKIEDHYRGDESEMKSEKSRSTSRRYSNDDYEDDRSTTKGDGDKGYQSDDGHRRRNGHTRFDGGRHGTEDLGSHAGSRRSRDGGARRSGSGERYGYGDDLGRRSSRMHNEPLAQQSPVPRYGGPLDRPPMGANVNGANAVGSPPPMGSPPQMYSPSFNSSGFQGSDPRGPPPTVQSTSTLRGGISTGYVPYAHLYGGPTHSQAQPQNGNYGQQPSSPSSPPAHPQPQNGNAYPPQGFPPSSQHNSPRPDSRHRNSPPPCARTVAPRPYHQNPFAQEAPPGNQPGYLIDPNHEPQRTSRDRDYDRQDTAASSRQSSPPRRHDSRRERRSKSHSRPRSRSHSRDRDRDRRRKSEKEKQKPQRQKSLRDRMTAFSQSAMDKVSEFSSEFSGGGDKKEQSMRRRSRDAERDREWSRRVNGRDGRERKERRASQPARSRVSYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB75</accession>
    <name>F9XB75_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_72674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852417.1">
        <property type="nucleotide sequence ID" value="XM_003852369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB75"/>
    <dbReference type="GeneID" id="13394195"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72674"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="InParanoid" id="F9XB75"/>
    <dbReference type="OMA" id="MVKWVLP"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="473" mass="53113" checksum="96F9CF57CADA5824" modified="2011-10-19" version="1">MIRSSFRRVPFACSLRNLASAGLPCVSSIRRHSGSKASPRAHFSTPTLDSPGKYHWIDGVERLDLYEPGGYHPVMIDDFLHDRYRIVDKLGHGGYSTVWLARDETAKRYVAVKIGISSPSPSRREPDILQALHASISSSIDASQRTALPSISDAFDIHGPNGTHTCYTLTPAQGNLKAASFSRLFPIQVARALAAKLATTIAFVHARGFVHGVLDLHLRNVLVGLPSMFDDLSIAEFREKFGQPDMVPITRIDEKPLTPNIPTQAVVPLYLGKKAQDFTLHDAYGLILSDFGEAFSPATEQRLGMEANIPLANRAPEALFEPNEPLSYPFDIWSLGLAIWDILGMKSIFSEAETHDEIVAQQIDVLGSGHFPDSWRMQWERQGEDEECTNIAIPRRPTGDRETWPSLEHAFEEFVQKYRRKREAAGSFGEDETRAILDLIRGMLRFRPEERLTIEDVLRSEWMLNWALPELEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCE7</accession>
    <name>F9XCE7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_100343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852355.1">
        <property type="nucleotide sequence ID" value="XM_003852307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCE7"/>
    <dbReference type="STRING" id="336722.F9XCE7"/>
    <dbReference type="GeneID" id="13396781"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100343"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.739"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="F9XCE7"/>
    <dbReference type="OMA" id="SVWGQVI"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="175" mass="19074" checksum="9D0E5B9B48E43D3B" modified="2011-10-19" version="1">MATPNQNPICFFDIALGGEPLGRIKFELFADVTPRTAENFRQFCTGETKGTTGRPQGYKGSKFHRVIKDFMLQGGDFLNGDGTGSISIYGTRSFADENFERKHTEAGLLSMANSGKDSNGSQFFITCAPTPHLNGKHVVFGKVVEGMDVVRKIESVRLRGEKPASDVTVAQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCZ9</accession>
    <name>F9XCZ9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_27323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851425.1">
        <property type="nucleotide sequence ID" value="XM_003851377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCZ9"/>
    <dbReference type="STRING" id="336722.F9XCZ9"/>
    <dbReference type="GeneID" id="13401408"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27323"/>
    <dbReference type="HOGENOM" id="CLU_1217313_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCZ9"/>
    <dbReference type="OMA" id="PTEWPIP"/>
    <dbReference type="OrthoDB" id="9950098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="228" mass="23770" checksum="A9B6FD3A2A06F276" modified="2011-10-19" version="1" fragment="single">SPVGTPGATPRATPRGTPMQTPRDTPMQTPVGTPMCSRRGTPVSTPRGTPAGTPVCSPPGSPCVPPPQIHVPMPKSILKSSPRITTPHSRQGSVNGNPSPTFNGFPRGTPAHSRQGSMNYDPMPSPNGLPRGTPVHSRQSSYPTSVPSRSPSGSPQHLQVPTPRGTPRGAPVHSRQSSQNDYFNISLPVNSTVPPGNLQVPAAKSPPRTTPTISRPTTPKATPRATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD84</accession>
    <name>F9XD84_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_73067</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851468.1">
        <property type="nucleotide sequence ID" value="XM_003851420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD84"/>
    <dbReference type="GeneID" id="13393641"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73067"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.299"/>
    <dbReference type="eggNOG" id="ENOG502SCS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064328_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD84"/>
    <dbReference type="OMA" id="TRRGTMF"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="244" mass="26792" checksum="67D26B7AB0C540E1" modified="2011-10-19" version="1">MASLLTSHLEQISLCASSIAELPFPGPKKFANALLSQHDITSLIRDTESHERALFHLAPPPLPTKPGAGNDYSSGPVTAPTPAPNRRATMYGGRQTPRNKAVAAVLGGDLYQRTRKEGTRQKGEVDVEVLLEGAERLLAVYSIPGASDRIAGLRRRHQQLTANIQYHEARVNQQSEDLAKISRKDYDAEDEDGGEDGSVAAAPAVMSREDMEREEVEIRELERKKKALEERVTGMEKDLGGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE49</accession>
    <name>F9XE49_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_27161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851993.1">
        <property type="nucleotide sequence ID" value="XM_003851945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE49"/>
    <dbReference type="STRING" id="336722.F9XE49"/>
    <dbReference type="GeneID" id="13401256"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27161"/>
    <dbReference type="eggNOG" id="ENOG502SKJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063723_1_0_1"/>
    <dbReference type="InParanoid" id="F9XE49"/>
    <dbReference type="OMA" id="GQFHFGM"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="29089" checksum="3D6DE087CC3843AF" modified="2011-10-19" version="1" fragment="single">TISLEARIPFNATGVDFDNGLLPFNPTSVHGKDQTFADVLQFPLVPPSLNDRPTDKAVEVTLNDKSIFAPSATNVQTGFRRTELIPTNKDASATASTEGVQKWHLSIRQDDTRPLNFSHEYYFFWLERADYSSNPFTLGTGTLFGDGDNKTSAQEAEQLWLRSSDASKQETLWQVPFTTGVWHNVAILLDFNQNLLQVEYSIDNQEPVKRTGLIPNDLSGNGQFHIGLLKKSTGLNLTDITKQGYQESGIDEGIVFGGAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE82</accession>
    <name>F9XE82_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MEP-1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_43998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851718.1">
        <property type="nucleotide sequence ID" value="XM_003851670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE82"/>
    <dbReference type="STRING" id="336722.F9XE82"/>
    <dbReference type="GeneID" id="13402006"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43998"/>
    <dbReference type="eggNOG" id="ENOG502S6EM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048726_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE82"/>
    <dbReference type="OMA" id="ALNTHYA"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="9">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="239" mass="25283" checksum="2ED7EC4E304CF3EA" modified="2011-10-19" version="1">MNVAIEAAADSFSAQAANVDVFVHVVTTSAKSSRYTQSQVNRQIQAMNSAYSSMAISFNLIDTDFTVNNAWAAAGQGSSAELAMKQALKKGSYGDLDLYFLSDLGGGLLGFCYFPVASPTTRDRQLDGCINLADSLPGGSATNYNMGYTAVHEVGHWFGLFHVFQGQSCSGAGDSVSDTPIQSTATSGCPVNKDSCPNAAGLDSIRNFMDYSYDSCMTGFSAGQSTRANSLYSQYRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEX8</accession>
    <name>F9XEX8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850986.1">
        <property type="nucleotide sequence ID" value="XM_003850938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEX8"/>
    <dbReference type="GeneID" id="13397726"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94760"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.724"/>
    <dbReference type="HOGENOM" id="CLU_1310984_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEX8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="210" mass="23872" checksum="27D33B3C83F77F63" modified="2011-10-19" version="1">MEENTTMNTCWRNTPSHILQKIITEVVLTPLRLTTTHSGRDMTRERVRAVDPEHCKDVIAMFHLSTTSRQHAKTVYRTSGAQQIVPRATVPGYRRLPSPPYLLSRPGFLFMEFGCDSTRPETRGTTLALFHEILSPLNTAFVNDLAWIEVKSTVCPTARANYPHFKSMLLSVCEAAAAEIWIFQRRNGRPMITAATCDIQIRSLVVWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFA8</accession>
    <name>F9XFA8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_26689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851218.1">
        <property type="nucleotide sequence ID" value="XM_003851170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFA8"/>
    <dbReference type="STRING" id="336722.F9XFA8"/>
    <dbReference type="GeneID" id="13397958"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26689"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048469_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFA8"/>
    <dbReference type="OMA" id="HRADGPM"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26978" checksum="E481027E0F7E71D5" modified="2011-10-19" version="1" fragment="single">DADDGYFIGARVLAYQLLHSKTAGTNSSIPFLVVCTLDVSKRKRDRLKADGATVIVIEKLDPAWVTAANPRWRDVMSKLRLFQLVEYSKICFIDADTLVTAPLDGVFFDEATLTQATGNTPDKILPDEAPLPRTYMFATHSDLWGYDHAFPPPPSMDYLNCGFFVFTPSLPLFAYYISLLSLPGRFDAGFPEQNLLNYAHRREGNMPWQPLWYGWNVNWPTARDWRGGARSFHAKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFA9</accession>
    <name>F9XFA9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_73832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850647.1">
        <property type="nucleotide sequence ID" value="XM_003850599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFA9"/>
    <dbReference type="STRING" id="336722.F9XFA9"/>
    <dbReference type="GeneID" id="13397957"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73832"/>
    <dbReference type="eggNOG" id="ENOG502S3KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039805_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFA9"/>
    <dbReference type="OMA" id="CIMCERE"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="514" mass="56078" checksum="21E94F6D4BB7A5BE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFB2</accession>
    <name>F9XFB2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_73841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850648.1">
        <property type="nucleotide sequence ID" value="XM_003850600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFB2"/>
    <dbReference type="FunCoup" id="F9XFB2">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFB2"/>
    <dbReference type="GeneID" id="13397955"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73841"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.208"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFB2"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28065" checksum="6C06C25BFA7C7EC5" modified="2011-10-19" version="1">MPAPTALQRAPEALAAEETKPSTQETHDDDIMITTTTPTEDTSNIIISDIPTMEVDSPSTTPLFPAEVPSKSAHRTEERKVRVPPHRMSPLKASWPKIYPPLVEHLKLQVRMNIAKKAVELRTSSHTTDTGAIQKGADFIQAFCLGFDLDDAIALLRLDDLYIQSFEVKDVKSLQGEHLSRAVGRIAGKDGKTKFAIENASRTRIVLADQKVHILGGFKNIHVAREAVVSLILGSPPGKVYGNLRTVAGRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGD0</accession>
    <name>F9XGD0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartyl protease</fullName>
            <ecNumber evidence="4">3.4.23.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MgASP4</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_110047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850563.1">
        <property type="nucleotide sequence ID" value="XM_003850515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGD0"/>
    <dbReference type="GeneID" id="13395306"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110047"/>
    <dbReference type="HOGENOM" id="CLU_621443_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGD0"/>
    <dbReference type="OMA" id="CATSFTS"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395499" evidence="2">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="62"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="441" mass="48234" checksum="99D1BCF21CC68A35" modified="2011-10-19" version="1">MWFSLCAALALVASTYAAPQPVNDDGFTPLKVITEANHLAKRDGHILPLFQVWDTGLSDYQMFGGIDVTVGGQTFRLLFDSAASDIWIPSASFKCYTAPVEGFEPSPENFCVNAVYHSDTLSGGIIDNLNYNETYVNGYNAFYGRAGYETVTIGGVTVKQQQIGFIDKGHWDVNTTAGCIGNDPLKDKESDRLPAINWHLNAFKEGSIAPVFSHIYDKGFFPVGHEIGKLVLGGIPDVELTTEWASSPILKVVKQDLREPLSEAALKNTPYPDYGKYKITGEGVTFTVNGKTFPALDGTGDTFFIEIDSGSVPVFAAKSVIEEIAAALDPPFKYDSKRDANSLFGPCNTILKDMTLNIGGVSLPISKDSLMYTTTDVPGPPLPSESNDECAIAFYPNYPKYDENYLFLGTRVLREFVTVYGRHQMDAAQTSVYVAIFEANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGE6</accession>
    <name>F9XGE6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851304.1">
        <property type="nucleotide sequence ID" value="XM_003851256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGE6"/>
    <dbReference type="GeneID" id="13395284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110052"/>
    <dbReference type="HOGENOM" id="CLU_1504628_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGE6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395500" evidence="1">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="179" mass="19667" checksum="66DFED3E3F7499E9" modified="2011-10-19" version="1">MWSLPKIGLLAPAYVLVFPAYTAGACLDHWHGTDHPAKPFGHAAVKRHEAAMIQKRDIISYIRLALTLRLIAEGFQGACDNHFGLLARGDGSGGLDLTVGPTGNAGANWLDTTIVIDPDSASDDAPRRIGYLTHAQYNDADSVTAHYSADETQHYMEANGYPQNHEFFIEIQYSIEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGQ8</accession>
    <name>F9XGQ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_94680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850828.1">
        <property type="nucleotide sequence ID" value="XM_003850780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGQ8"/>
    <dbReference type="GeneID" id="13397756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94680"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.609"/>
    <dbReference type="HOGENOM" id="CLU_1373204_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGQ8"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="22322" checksum="2A8FA7218A73C73A" modified="2011-10-19" version="1">MDPIEMLHEFLFFDADEDTAPPDEPEPFYDNITSTAFESDTIDAFITAWEEEERTAALAEDFPCKAPKFAEGHLERPNSGTAQIYNADSVPPTFKLSEPVKEAPYFVVVSAGSLKTKWGVLKDEKTNAARLEKIQEPCGICLEPNEKPCGPRCGHLFCYDCVSLVLESQMERLCPYCRGVMDFGNLIEYVVCGEETKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGV2</accession>
    <name>F9XGV2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_110366</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849944.1">
        <property type="nucleotide sequence ID" value="XM_003849896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGV2"/>
    <dbReference type="FunCoup" id="F9XGV2">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGV2"/>
    <dbReference type="GeneID" id="13395049"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110366"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="InParanoid" id="F9XGV2"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="323"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="553"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="615" mass="68574" checksum="7328334E00D07A2E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP3</accession>
    <name>F9XHP3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850381.1">
        <property type="nucleotide sequence ID" value="XM_003850333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHP3"/>
    <dbReference type="FunCoup" id="F9XHP3">
        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHP3"/>
    <dbReference type="GeneID" id="13394884"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45983"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHP3"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41248" checksum="C896BAC53F319074" modified="2011-10-19" version="1">MVNITEKIKEIEDEMKRTQNTSEYHLGLLKGKLARYRAQLLEPGPGAGGPGGTGFDVQKSGDARIALVGFPSVGKSTFLSKVTKTKSEVAAYSFTTLTAIPGVLEYGGAEIQVLDLPGIIEGASEGKGRGRQVISAAKTSDMVLMVLDATKRAEQRALLEAELEAVGIRLNQAPPNIYLKPKTAGGMKITFSSPPKYLDQKMLYNILRDYKILNCEVLVRDENATVDQFIDVIMRDHRTYIKCLYVYNKIDSISLDFLNRLAREPNTVVMSCELDLGIKEVVDRCWDELHLIRIYTKRKGIDPDFSEALIVRNNSTIEDVCDQIHRTIKDSFKYALVWGASARHVPQRVGLSHVVADEDVVSIVGTKSGLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP9</accession>
    <name>F9XHP9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_110461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850378.1">
        <property type="nucleotide sequence ID" value="XM_003850330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHP9"/>
    <dbReference type="STRING" id="336722.F9XHP9"/>
    <dbReference type="GeneID" id="13394240"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110461"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.381"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_2_1"/>
    <dbReference type="InParanoid" id="F9XHP9"/>
    <dbReference type="OMA" id="EWYVNIS"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
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        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="457" mass="48913" checksum="86931D036BC63B9F" modified="2011-10-19" version="1">MAEAPAYPPAMRKKVLKVLVISLILDLISFTFILPLFPKLLEFYRNTEAESGHTVLSNVLYGLNTYKNSFAKPINDRYDIVLLGGALGSLFSFCQAIASPIIGTLSDRYGRRTALMWSMCGNIASVALWCAATDFRTFLASRVVGGLSEGNVQLAMAIATDISSDADRGKTMALVGVCFSVAFTFGPALGAFLANITTVAANPFATAAGVSLALIVTETIYLYFALPETHTNRRTTHIGTAAKSHPVVKGQRTNSHLILNLTHFTFILFFSGMEFSLPFMTYDLFSYGSKDTGKLLGYIGLVASLLQGGVTRRMHPLRVVQLGVASAAVAFFVLSNTNTERMLYVAATLLAVTSSTVVTGLNSLSSFEASSDERGEKLGNHRSFGQVGRALGPLIFCTLYWWAGRDAAYIIGGSGMVAVCGLVFGGLKAPKGLEGKKIAEVEKVVEEKANGKAVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHQ2</accession>
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            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">MYCGRDRAFT_105472</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="3">Interacts with ERF2.</text>
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        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
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    </comment>
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    <dbReference type="eggNOG" id="ENOG502S30T">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28870" checksum="A7053030DDEBE11C" modified="2011-10-19" version="1" fragment="single">MQAFNKLAGVQEASDTTQPSHPTLAPESYPPLPPIPQDEDRSFDARSSRRGSQHSVGLPSRTHRSNLSLHSRRSIARSRPGSTKGSRALKGTHSRDNSDDADTAQQQQQPRASHDSEQQQYEEDDAYTEDEDDEFTWGPSHPCFPHPNPHCSPDSLAAHTTRVIRIRRDWLASGDLYPQYANLYPEILSPLISDYEFRFLLSNINAILARAFTPYSTRAWFDAIVGVLTGYAWEDCGFTGARIGEHELERFMRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHR7</accession>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849814.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13395205"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94869"/>
    <dbReference type="HOGENOM" id="CLU_2186058_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHR7"/>
    <dbReference type="OrthoDB" id="10459675at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="109" mass="11752" checksum="E099074A56E48BC4" modified="2011-10-19" version="1">MPMALMIEPRSIVVIAKDMIQPHLPPKSTKSTMSLQNTHLDPASAGSASNSQSTSATTSRSQTPAGDRRKSGAYDSAPSQGVWEADKERQHKGFLQMVLGNKLTPSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHS3</accession>
    <name>F9XHS3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_74317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </dbReference>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIE6"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XIE6"/>
    <dbReference type="GeneID" id="13402716"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74463"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.130"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="InParanoid" id="F9XIE6"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="251"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="414" mass="45238" checksum="B01F8673480D65FB" modified="2011-10-19" version="1">MPIQPDNPEPAHASLDSMLSRKFGKEVANYFSGSPLNRVGFLRGDHKFLSQALRHPSTTFLLCNDLQPLVQPNTTPGAGKLAWVKYDDVKSIIGSDPFATTEKEMIEAYNSSTYVPQMVFLGIDEARKDGLAYQGKNLYTGAPYFAVDVTPREETLREACEGLIERLKGEGLEFSKGRVMDVVASDAAIYAEARQLLDWNLRNPFCAACGHRTLSINAGFKRTCPPKDASTPDSSRPSCVTRHGISNLCFPRTDPTVIMAVVNAAGDKLLLGRQKRWPPYWYSTLAGFAEPAESIEEAVRREVYEESGILVGRVVIHSTQPWPYPANLMIGAIGQAIGGEGERIDLGNDPELDDAKWFAFDEVREALRVGTSGLGEDAGEGYNEGGLRLPPNTAIANQLMTAVCNGFASGEMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIG8</accession>
    <name>F9XIG8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_45920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849935.1">
        <property type="nucleotide sequence ID" value="XM_003849887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIG8"/>
    <dbReference type="GeneID" id="13402729"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45920"/>
    <dbReference type="InParanoid" id="F9XIG8"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="579"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130207" checksum="F8DCE3C71FD1BE70" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIQ2</accession>
    <name>F9XIQ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
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        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
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        <property type="protein sequence ID" value="EGP84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003849762.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XJ36"/>
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    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000901_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ36"/>
    <dbReference type="OMA" id="GSTDWPA"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:establishment of protein localization to chromatin"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
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        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12765">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1288"/>
            <end position="1474"/>
        </location>
    </feature>
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        <location>
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            <end position="531"/>
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        <location>
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        </location>
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    </feature>
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        <location>
            <position position="1695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84786.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1695" mass="185745" checksum="4D5F29F5896CD787" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
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            <end position="116"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJC5</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_75719</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13402450"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75719"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.419"/>
    <dbReference type="eggNOG" id="KOG0725">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJC5"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="33209" checksum="2668C935F857309E" modified="2011-10-19" version="1">MASAAPKKRLQQLSEHLVNRPRSIGNSFEDLPNIPMVAGDSIGPRAKGKVVIITGCNSPLGIGRASAHHFANNGAKAIYICDLNTEHLDKHKREIEQKYPGTEVHPRQVDAGEESDVAKVVDDALEKYGQLDVFFANAGISVTMGSVLDGSAQDFMQVMKINSLSVFLAVKHGARGMLKTSATKKYPGGSIVSVASSAGMRSNAGATDYSASKAAVISIMQTSAYQLSGTGIRCNAICPGIIETGMTAPMYEMARARGSESKIGQLNPLMRGGVADEVARVALFLGSEEASYVNGQAWAVCGGLTAGHPFVPGKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJH8</accession>
    <name>F9XJH8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_87443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849767.1">
        <property type="nucleotide sequence ID" value="XM_003849719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJH8"/>
    <dbReference type="STRING" id="336722.F9XJH8"/>
    <dbReference type="GeneID" id="13399046"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87443"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.203.1"/>
    <dbReference type="eggNOG" id="ENOG502SKH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090716_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJH8"/>
    <dbReference type="OMA" id="ECGTHMY"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="186" mass="20211" checksum="A255C78042F69621" modified="2011-10-19" version="1">MPNIHPILDNGFQKGSDNFNGGTLKCHCPSSPVTVSIKGNVLHNHFCGCSLCWKPTGSLFSLVGVVSKDNVSVTANEYKLKIVNPEAAIQRNACKECGVHLFGRIVQDHPFKGLDFIHVELSQEKGWQEPQFAAFVSSVIEQGAEPSKMDEIRSAFKKAGLESYDCLSPALMDAIATFVAAKKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJJ5</accession>
    <name>F9XJJ5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_110715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849358.1">
        <property type="nucleotide sequence ID" value="XM_003849310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJJ5"/>
    <dbReference type="GeneID" id="13402555"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110715"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.221"/>
    <dbReference type="HOGENOM" id="CLU_2199084_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJJ5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="11201" checksum="EE0CDE5047B14A2C" modified="2011-10-19" version="1">MACNAPKTWLELVHAAHVFMKSFKAKPNPLTGFADLLSASIDCRVDFLPRPLFLTPEGSGVTLGGATIAAEAGSDGRAATLGATVLLLEDDLESLPGTDFAISTAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJT5</accession>
    <name>F9XJT5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_28261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849502.1">
        <property type="nucleotide sequence ID" value="XM_003849454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK19"/>
    <dbReference type="GeneID" id="13402412"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62658"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033641_3_0_1"/>
    <dbReference type="InParanoid" id="F9XK19"/>
    <dbReference type="OMA" id="YFPCGMY"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="76"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="371" mass="40402" checksum="212B9CC500C5B9D9" modified="2011-10-19" version="1" fragment="single">MSDEAKDDRRISFNSMDSDNTLSGTTRAQSMEEAHRLLAKEEPRDIEAQQQFEQLSLPQTPTTPMEYSVSTNRKFLYLGLYFLLNLSVTLSNKALLKIASYPWLLTFSHTCATSIGCTILLATGHLKLSKLPLRDHLVLIAFSTLFTLNIAISNVSLDLVSVPFHQVMRSTCPIATILIYRLVYSRTYSHETYLSMIPLIIGVALATFGDYDFTLPGFTLTALGVLLASIKTVATNRLMTGSLKLSALEVLFRMSPLAAIQCLLYAAGSGELSRLQVTAADGLLTRGLLSAAVLNASMAFGLNLVSFQTNKVAGALTISVCGNVKQCLSILLGIVLFNVRIGWVNAVGIVISVGGAAYYSKVELDIKRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK99</accession>
    <name>F9XK99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_110759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849703.1">
        <property type="nucleotide sequence ID" value="XM_003849655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK99"/>
    <dbReference type="GeneID" id="13402500"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110759"/>
    <dbReference type="eggNOG" id="ENOG502T2ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026305_6_1_1"/>
    <dbReference type="InParanoid" id="F9XK99"/>
    <dbReference type="OMA" id="GAMETIS"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390729" description="DUF7580 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="404"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="600" mass="67522" checksum="06D5D6C1312132E0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKM9</accession>
    <name>F9XKM9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_111010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849151.1">
        <property type="nucleotide sequence ID" value="XM_003849103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKM9"/>
    <dbReference type="STRING" id="336722.F9XKM9"/>
    <dbReference type="GeneID" id="13398623"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111010"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.221"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKM9"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="423" mass="46031" checksum="E9CA2A74B8D1E1FF" modified="2011-10-19" version="1">MFSQRVSTRLLQHSRHFSSTTFRNADFTHAVIGAGAVGLAIARRLQQVEGASVVLIEKHGMVGTETSSRNSEVIHAGIYYGADSLKTKFCVQGKEMMYDLCRKNSISHKNCGKWIVAQTAEQMGECEKVHDFAKSIGVPIRYISKEEAQRREPEVRAEAGALESPTTGIVDSHAYMQFLQGDFENEGGTLAIQSPVTRIESPSSNGTPDWKIWTATEASDITASSPIPQIPEQSPLPDEDTFITAETVINSAGLYAIAINNMILPPDRHLKPFYAKGSYFTYSKSHPKPSTLIYPAPTPGHGGLGTHLTIDMGGQIRFGPDVEWVDSPHDLAPTASAERFAAAIEEIKSYLPGIDVDAVSLGYCGIRPKLGKASATAGGKTFQDFYIKREEGVQGFVNLLGIESPGLTSSLAIAEEVHRLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKQ1</accession>
    <name>F9XKQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_76271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848854.1">
        <property type="nucleotide sequence ID" value="XM_003848806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKQ1"/>
    <dbReference type="FunCoup" id="F9XKQ1">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKQ1"/>
    <dbReference type="GeneID" id="13398614"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76271"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.243"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="F9XKQ1"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="351" mass="39074" checksum="A6703AD3070CED85" modified="2011-10-19" version="1">MARAESSKDAETNGVKANTRGAPANYELPWVEKYRPVFLDDIVGNTETIERLKIIAKDGNMPHVIISGMPGIGKTTSVLCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPAGRQKIVILDEADSMTSGAQQALRRTMEIYSGTTRFAFACNQSNKIIEPLQSRCAILRYARLTDGQVVKRLYQICQAEKVEYSDDGIAALVFSAEGDMRQAINNLQSTHAGFGFVNGDNVFRVVDSPHPIKVQAMIKNCQEQKIDDALDGLKELWDLGYSSHDIISTMFKVTKTIPSLSEHTKLEFIREIGFTHMRILEGMQTYLQLAGCVAKLCKLNMKPQLFDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKR1</accession>
    <name>F9XKR1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848861.1">
        <property type="nucleotide sequence ID" value="XM_003848813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKR1"/>
    <dbReference type="STRING" id="336722.F9XKR1"/>
    <dbReference type="GeneID" id="13398031"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105930"/>
    <dbReference type="eggNOG" id="ENOG502RN9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442149_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKR1"/>
    <dbReference type="OrthoDB" id="10556887at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="188" mass="21291" checksum="C5E024C2ED3F5C04" modified="2011-10-19" version="1">MWTGPPPAADAAYRQQAQSQPASQRYVQVSHQTPQEFQRQIQGLPSTASREGAHARMLREQGYQAYSPSTGFPRNSFGQTYDTAKMWHSPQAPTPSPLSDPNTPGYAHSRGQTPNNMTHWNAMARPDMSYMVTQRAPQQHYQPQQYQQQPPPPQQQYQQQLPQQQQAPGAGYGPMLPQMGGHETWRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKV5</accession>
    <name>F9XKV5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_48752</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849010.1">
        <property type="nucleotide sequence ID" value="XM_003848962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKV5"/>
    <dbReference type="GeneID" id="13398332"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48752"/>
    <dbReference type="eggNOG" id="ENOG502SKGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039745_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKV5"/>
    <dbReference type="OMA" id="KVFAWME"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="123"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="37603" checksum="EBE0448796C70861" modified="2011-10-19" version="1">MVEPNPLPNGHPGSILLFTYPQSVFGHRIRRYLDFRSLPYTLIRVPPNMPRPLLQLRLGVNYRRIPIMSIGRDIYIDTRLMISKLETLFSEGALGAKTPFEAALEDMLEEFMVDGGPFWRMAGCIPPNADLMQDSVGVADRSEGSGGAFTKEALKENRAWSLTQVKVYFGMMEKMLGDGREWVMGGAEPGLAEIHAGWVFEWGVGMTGSGEDEGTEDLKRTLSREEFPRVWAWTERFRQAAEEARRGNEGAVEMQEGQEAEDETVLKVDLDDALGLKAGQRVEVAPADFGFTHKNEGVLVGLTKDEAVIEIDVPGEEDGKLRLHYPRINFKIEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLS0</accession>
    <name>F9XLS0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_18438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849066.1">
        <property type="nucleotide sequence ID" value="XM_003849018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLS0"/>
    <dbReference type="STRING" id="336722.F9XLS0"/>
    <dbReference type="GeneID" id="13398182"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18438"/>
    <dbReference type="eggNOG" id="ENOG502TH8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="InParanoid" id="F9XLS0"/>
    <dbReference type="OMA" id="HARYWID"/>
    <dbReference type="OrthoDB" id="3640777at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="155" mass="17924" checksum="4E05C0AF9D4E01F1" modified="2011-10-19" version="1" fragment="single">LHNAPPFAALSYTWGQDDPNCHIEVNSGMLPVTKNLLRFLLQARQLPAYASRYFWTDAICVDQTDLEERGQQVSLMADIYSSAALVVLWLGPAYEESDLGMRAFTRIRTTTQSDDTKSQILWRSREGTAIRRLCERRYWTRLWVLQELALADRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLT3</accession>
    <name>F9XLT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848941.1">
        <property type="nucleotide sequence ID" value="XM_003848893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLT3"/>
    <dbReference type="ESTHER" id="zymti-f9xlt3">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="GeneID" id="13398186"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111117"/>
    <dbReference type="eggNOG" id="ENOG502QSW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_3_0_1"/>
    <dbReference type="InParanoid" id="F9XLT3"/>
    <dbReference type="OMA" id="TTSIWTQ"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390838" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33275" checksum="2FE38E8915CF773E" modified="2011-10-19" version="1">MSLLTPLLLLISSLALASPLLPRAVPAFAFDGDAPFTVNADGLAASLTCPNGNPTTKSPPVLLVHGTATTGQETWADGYVPALKANGYTACYITIPNRSMGDMQVNAEYVAYNLHYLSSLSGGLPVAVIAHSQGNPNVQWSLQFWPSTRKVTRAFVALAPDFNGINLFDSALSEVCKTGLCQPALWQQSAGSQYYKALHANRFTAQVPTTSIWTKYDGIVSPSSRNAQLPGATVISIQDLCPLRPTIHTTMTVSSAAYSLALDALNNEGIASLSRVRKNAFSICLRVSAKNMKSSVADDLTSLFDNLVKGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLW6</accession>
    <name>F9XLW6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849043.1">
        <property type="nucleotide sequence ID" value="XM_003848995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLW6"/>
    <dbReference type="GeneID" id="13398440"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96368"/>
    <dbReference type="HOGENOM" id="CLU_354969_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLW6"/>
    <dbReference type="OrthoDB" id="10486655at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="87592" checksum="3FB91902C7913B10" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLZ9</accession>
    <name>F9XLZ9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_76577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848975.1">
        <property type="nucleotide sequence ID" value="XM_003848927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLZ9"/>
    <dbReference type="STRING" id="336722.F9XLZ9"/>
    <dbReference type="GeneID" id="13398347"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76577"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.498"/>
    <dbReference type="eggNOG" id="ENOG502R6U3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707921_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLZ9"/>
    <dbReference type="OMA" id="CVIPEYT"/>
    <dbReference type="OrthoDB" id="2821964at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="441" mass="50286" checksum="E555A2AC3A6B553B" modified="2011-10-19" version="1">MQKPAYKWYYPADIENDLNGIDLPAAIKAEVLACAWEYSRSVIPQYTNWKRYVAFMRTIIIGTIAEFRGAMLDVTSDTPILGFDLDQVLADLFEGTPGHEDMAREYKTFLTVTSDKTSDRRDHELFRRYKKAVSSSPQNWFRLRDCDALCRFAIAAALACNDMDDVWFTDEQFDALAEIGDTMYDAIAFYKHRAEGETNNTFAYVPEDMRVDAFRTARETLWALDTAYADRPEMQVVVNFLRAFGGPIHMIMRRYRFCEEGLVIGKAEDTSVIDAARKHEKLWHRLDQQEIVLQQGVERCELIFSMENRLLFRGFTDILLDADRSDSPLEFPSSPVEKNGFGGALAHQAAGQIWKSYALRLPERVRRAFPEVCLNPCLPQAFAQPIEKFPRGKVVAEVVGAPTAITQASQKRSYGGDDGGNGKQYKERRIDQRARSTLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMC4</accession>
    <name>F9XMC4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848481.1">
        <property type="nucleotide sequence ID" value="XM_003848433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMC4"/>
    <dbReference type="GeneID" id="13396458"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96858"/>
    <dbReference type="HOGENOM" id="CLU_1897850_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMC4"/>
    <dbReference type="OrthoDB" id="10394530at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="15522" checksum="A5C4DCECE32694FB" modified="2011-10-19" version="1">MAMLFTTPADSFTMTTRSMSRHGTRAVIKVRPVRRQKIWLRLPGCYSPRPHKGKKSGIVLSLKKKKNGQTGWVGKGESFYLARSSKRRAYPERDPVPRTSRIVPPAESRSLMTIDFRLRITLTRNLYHSHHRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMH2</accession>
    <name>F9XMH2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_96467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848725.1">
        <property type="nucleotide sequence ID" value="XM_003848677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMH2"/>
    <dbReference type="GeneID" id="13396357"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96467"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.40"/>
    <dbReference type="eggNOG" id="ENOG502S39Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046555_1_0_1"/>
    <dbReference type="InParanoid" id="F9XMH2"/>
    <dbReference type="OMA" id="KLCFPNE"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF9">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130652" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="238" mass="25373" checksum="A68ED373D2CB3CAB" modified="2011-10-19" version="1">MRTTLTLLALAEVSTFAFGYDIPDNLRDIYSNHKSGKCNNKLAGGFDDGSLAYCGDIPHAIYLHSQRNGGRYDNMDIDCDGANRSAGRCSNDPTGQGETAFKDTVKQYGISDLDANKHPYVVFGNSGSNPSFNPEDEHMHPLSVMAVVCNNQVHYGVWGDTNGGTSTGEASLALANLCFPNDSLSGDNGHGEYDVMYIGFKGTHAVPGDSANWKAGSAKEFQSSIKDLGDSLVAQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XML2</accession>
    <name>F9XML2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MYCGRDRAFT_96502</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848707.1">
        <property type="nucleotide sequence ID" value="XM_003848659.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XML2"/>
    <dbReference type="GeneID" id="13396108"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96502"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XML2"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="784"/>
        </location>
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        <location>
            <begin position="808"/>
            <end position="962"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="1127"/>
            <end position="1155"/>
        </location>
    </feature>
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        <location>
            <begin position="1180"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1356"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
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        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1385"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="1397"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1455" mass="161806" checksum="02355FCCF34E14A3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMN8</accession>
    <name>F9XMN8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Actin-related protein, ARP4 class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARP2407</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_76713</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003848258.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76713"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.106"/>
    <dbReference type="eggNOG" id="KOG0679">
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    <dbReference type="InParanoid" id="F9XMN8"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="472" mass="51478" checksum="88BA181E6F5B9A36" modified="2011-10-19" version="1">MASTVPATQPPNQQEYAGDEVNALILDAGSYTTRAGFAGEDTPKSVTPSSYGLLSSGEKVFGENAIHLPRPDMEIRSPFNSDGIVEDWETATKLWEYSITSRLTGSRQTPPSKNGLNDDKDENGDTSMAEAEQTEEQERVLGEYPLLMSEPGWNPQKAREKTIEIAMEEWGVPAFFLAKTGQLAAYSQGKPTALVIDIGHHNTSVTALWEGMVLKKSVHHTPLAGSWLNDQVRLMLGSLTPPAPLTPYYMVKSKQPVDAGAPSNAVYTTFDKPPAASFRALEEDRVLTSFKESLVQAWPGPARLDSPAGGGGFTNADHAKQLPPKPFEFPDGWNQVFGIERYKVAEGLFDHNAAYTDSEHAAPTGEQTITSIAKRALDAVDVDARPQLMHNIVLTGAGSLIDKLPERLQSDLQALYPNPKIRVIASSNSAERKFGSWIGGSVLGSLGTFHQMWISKGEYEEFGKSIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN29</accession>
    <name>F9XN29_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848366.1">
        <property type="nucleotide sequence ID" value="XM_003848318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN29"/>
    <dbReference type="GeneID" id="13396148"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106127"/>
    <dbReference type="HOGENOM" id="CLU_2348294_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN29"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391785" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="97" mass="10577" checksum="8081BF82CFC95BDC" modified="2011-10-19" version="1">MKLLTTTLFITLISTTLAIVSPPCLDYHSPRPNHLQDPPYPPGTCKESDEELGPNYPYGVCDVEIAGSRKQAPGQIEAPCGKVTQNPHDELLRLACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNJ9</accession>
    <name>F9XNJ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847907.1">
        <property type="nucleotide sequence ID" value="XM_003847859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNJ9"/>
    <dbReference type="STRING" id="336722.F9XNJ9"/>
    <dbReference type="GeneID" id="13401521"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96993"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.146"/>
    <dbReference type="eggNOG" id="ENOG502SAV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070614_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNJ9"/>
    <dbReference type="OMA" id="YEARCVI"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="318" mass="34848" checksum="2036CA9862AA230E" modified="2011-10-19" version="1">MAITGAAPGISAIILVDGEPLKEYIDNTIEDGDDTVTRFVEALSDKNFRILLQVEKGTEITRAAVSFAIFVDGESLANPFIPTSWFQSSNGTSIIEGKELPNGMIQKLKFITLETVSDGRGFVKGASDMSVLGTVIVDVSFVDIVAVETFDELSKNSALGGPGIVHEEAIKGEAITHGVNFENPVALGQDPTEVWTSYNEDQKSYSRIVLKYRSLEALQSMGIIPRAPSPEPIERRAPETLTLEEIVELQKSFVSQQAKKDTMVKIKRERGENARPRKRSRLTPGATYLSLDDDEQGVRELSTATLDPEEETEVIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNK3</accession>
    <name>F9XNK3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mg-dependent DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_96997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847909.1">
        <property type="nucleotide sequence ID" value="XM_003847861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNK3"/>
    <dbReference type="FunCoup" id="F9XNK3">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNK3"/>
    <dbReference type="GeneID" id="13401676"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96997"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNK3"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35645" checksum="27F04504A33A0A18" modified="2011-10-19" version="1">MGSQAPPPEANNTPTHPTLRYADIGINLSDTIFRGHYHGKQAHEDDLQHVVSRARAAGVQKMMITGSDYTESKNAINLAEEYPGLCYATVGVHPCSASTFAKAPQGGDQLLKELGQLAREARDNGTATAFGEIGLDYDRLTLCDKETQLTWFAKQLDLAAELNMPLFLHSRAAASDFERLLTSRLEQLPKRGVVHSFTGSLEEMQRIVALGFDVGINGCSMKTEENLAVVKEVPLERLQIETDGPWCEMRPSHASAKFLGEAPELPKAVKKEKWNEECMVKGRNEPCAISQVAYAIAAVKGVPVEEVCEAAWNNSIRMFGLGESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPL5</accession>
    <name>F9XPL5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_88373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847511.1">
        <property type="nucleotide sequence ID" value="XM_003847463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPL5"/>
    <dbReference type="STRING" id="336722.F9XPL5"/>
    <dbReference type="GeneID" id="13401308"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88373"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_1"/>
    <dbReference type="InParanoid" id="F9XPL5"/>
    <dbReference type="OMA" id="DTWGLGV"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="248" mass="25883" checksum="5F9E14EFBF584D8D" modified="2011-10-19" version="1">MSTLPSNALLGPRDGLQNIAVQVPTPVKIELIQRLADTGIKHIEATSFVSPEWVPQLADGAEVMQSILPLAREKSIELQVLAPSMKGLENALAAGATQVTVFASATEAFSKANQNCTVDQALDAADQVAKKALSQGLNVRGTLSCIFSDPYSGPTDPKEVVRVAKRFHDMGCYQIGLGDTLGVGTAAVANVMASYDMGIRIFDAAVAGLGGCPYARGAKGNLSTEDIVYAFENSGIITGVDLAQLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM0</accession>
    <name>F9XPM0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS maltose permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_12471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847831.1">
        <property type="nucleotide sequence ID" value="XM_003847783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM0"/>
    <dbReference type="STRING" id="336722.F9XPM0"/>
    <dbReference type="GeneID" id="13401306"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_12471"/>
    <dbReference type="eggNOG" id="ENOG502RRIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011673_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPM0"/>
    <dbReference type="OMA" id="EWSWKSR"/>
    <dbReference type="OrthoDB" id="5408102at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57548" checksum="9B3F77AFF7D3E963" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM1</accession>
    <name>F9XPM1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_77668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847830.1">
        <property type="nucleotide sequence ID" value="XM_003847782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM1"/>
    <dbReference type="FunCoup" id="F9XPM1">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPM1"/>
    <dbReference type="GeneID" id="13401305"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77668"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_1_1"/>
    <dbReference type="InParanoid" id="F9XPM1"/>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="182" mass="20979" checksum="CEAFEB629F281E20" modified="2011-10-19" version="1">MQRIDPRPDPPVDGTQQQQPQQQTNPHKTSWTLPTGFASTGRESHTQSFEEIYGAPENFLEIEVTDPQTHQPTSSPSSRYTTYLIRLSTNIPAFKLRRSEVRRRYSDFEVFRDLLERESARVSIPALPGKVYLNRFDDAVIEERRKGLERFLKIVVGHPLLQTGSRVLGGFVQDPGWERDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ14</accession>
    <name>F9XQ14_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_111641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="CM001208">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003847712.1"/>
    </dbReference>
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        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ14"/>
    <dbReference type="GeneID" id="13401006"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111641"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.182"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_035066_5_2_1"/>
    <dbReference type="InParanoid" id="F9XQ14"/>
    <dbReference type="OMA" id="QNMGQGW"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
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        <property type="component" value="Chromosome 13"/>
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    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
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        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="292"/>
            <end position="310"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="409" mass="46047" checksum="32DD7ACC8217678A" modified="2011-10-19" version="1">MGYIRQEQLPKLKEYKYSGVDKSLLSQYILKPYWWSQVVKLFPLTVAPNAITLLGFSFVIINILTLLYYTPTLDQECPSWVYASWSIGLFLYQTLDAIDGTQARRTGQSGPLGELFDHGVDALNTGLEVLVFAACMRFGMGWRTVMIMFGGLLTFYVQTWDEYHTHTLTLGLVSGPVEGILTLCIVYGITAFTGGSYWLQPMLPTLGVPHFSFLPSVFYTMDFGDFYMWYGGLMLIGNVLESSRNVLKARRERGQRTRVALLGLLPFAASWFLIISYLYLQPIILHHHLVPFILYVALINAYSVGLMITAHLTKSSFPYHNVIVLPLVYGVLDSLGPVLQRNVGHWAGWPSSLGEGTYQVAFMFTCLGLAVGVHGSFVLDVIVSICDYLDIWCLTIKHENVPVEEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQJ6</accession>
    <name>F9XQJ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="88" mass="9995" checksum="73FEFF27FA89E7DE" modified="2011-10-19" version="1">MVIINNFDNDTRQPRASLYEYPQPTSTTTAVQCRSKAMNMTRGAARTRRQEAGWETQDAGWFQTCEHANTKSVEELDGRRRAGCVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847443.1">
        <property type="nucleotide sequence ID" value="XM_003847395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQU9"/>
    <dbReference type="GeneID" id="13400578"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97615"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.107"/>
    <dbReference type="HOGENOM" id="CLU_1519057_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQU9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="177" mass="19708" checksum="741FFDEE3CA3588A" modified="2011-10-19" version="1">MVPPPVELPAEPMAAFDNLTTTTANINPDVDINPDEDTSSDEDKPFKPYEDSNSDKDIKPDANIKSKERRPIKQDQHFVIDHRPVKFKGPTPTHRIIKRGGQPPSNAATHRASHFDESSVKRTLLPSGFTVPEFLQAEDVWDLRQAGDKRVSGISVVFYAGAEENGSVDLEEEAKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="5 6">
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="13399878"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97717"/>
    <dbReference type="HOGENOM" id="CLU_317660_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR57"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NUDE"/>
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        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="722"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="917" mass="101955" checksum="18B8ECF81125EFC4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR70</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847287.1">
        <property type="nucleotide sequence ID" value="XM_003847239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR70"/>
    <dbReference type="GeneID" id="13399884"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97730"/>
    <dbReference type="HOGENOM" id="CLU_535520_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR70"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="509" mass="58122" checksum="979A320089BAAE69" modified="2011-10-19" version="1">MDSRRRMSWKAVLLEEPDRSDGDLEDYLRKSGSHRTDELKDVGLNIKRFGRRRRPLMRAVMSCYAVVACEPSFTTACVMDCPFSQTGLLEDIAIVLDDLDNHLRDRKENVDEPKDVGLNNREDGQKWRELPTKLLFYCLGLGLSQTGLLERRRYRSGGSWLSPLEERECHRGLNIKRIAKLVQAARLPPCARLGDVRYRSGQSRHHLWKSKMSSNDENVGLNIKRIAKLAPLARRVRFEKTDPLEHTTRKLKNVGLNFTFQERNVTELRDVGINIKWIAKMVQLRLCVQREKTGLLEDTAADLENHEITFGRQDGHRTQRSRSQRYLHLLNQNVNELKDFGLSIMLGKQNVIELKDIGLNITFVPSRGSALNGAERFKAKANDWPSKHVLGHEESVREKAKAKDYPTKPASFRMNNDSEVKASRRIRDVVEIANRQEQKEKPHQRRTRIFGAACQTTSPRKQARAGLGFSISAGGGAQDDRFVLKNGGVEAFRELEGSAVLAARCYKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRC3</accession>
    <name>F9XRC3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_51727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847256.1">
        <property type="nucleotide sequence ID" value="XM_003847208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRC3"/>
    <dbReference type="GeneID" id="13399906"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51727"/>
    <dbReference type="HOGENOM" id="CLU_085149_5_1_1"/>
    <dbReference type="InParanoid" id="F9XRC3"/>
    <dbReference type="OrthoDB" id="3693885at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="54" mass="6110" checksum="77EFF35071E0C41C" modified="2011-10-19" version="1" fragment="single">KTPEELFTGTKPSGKHLRVFGYITYTLIPNEQRVDKLEDSVYSGIFIGYSPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRC8</accession>
    <name>F9XRC8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_97780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847215.1">
        <property type="nucleotide sequence ID" value="XM_003847167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRC8"/>
    <dbReference type="GeneID" id="13399870"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97780"/>
    <dbReference type="eggNOG" id="ENOG502RA3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322159_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRC8"/>
    <dbReference type="OrthoDB" id="5429358at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="516"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="899" mass="101014" checksum="CECAE80FA798B8FB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRM5</accession>
    <name>F9XRM5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847126.1">
        <property type="nucleotide sequence ID" value="XM_003847078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRM5"/>
    <dbReference type="GeneID" id="13399480"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106652"/>
    <dbReference type="HOGENOM" id="CLU_1788353_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRM5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="15630" checksum="DCCAF2E160F162A5" modified="2011-10-19" version="1">MQEVWDLEQCIAEDATMASSSFHELAGRAVTSGPWKIRYCVREFRPACRDGNSTARGDGHSTARGDGHSTARGDGHSTARGDGHSTARGLDTLPSFIHALDSIFKPATHARYISLVSPMCLAPSTRATRPSNRTPPRTTSPRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRQ7</accession>
    <name>F9XRQ7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847103.1">
        <property type="nucleotide sequence ID" value="XM_003847055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRQ7"/>
    <dbReference type="GeneID" id="13399455"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97902"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_18.75"/>
    <dbReference type="HOGENOM" id="CLU_1147972_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRQ7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="26531" checksum="75F2D2A67F4EB9BE" modified="2011-10-19" version="1">MQEQKEDILVLKVRVEALKEELAAESSNCTDSLNNRPGCGMTTVVRNVFHRLPTVAELDAILREKALRASTIRRIALEWMETHTLARGTEQQQQHHHHHDRSHPQTSTSTSTTTPPPASCIPPPPPRSRRFPPTTTPSPHDHLAATAQRIHRLIWTHPKLGAASWHWEGSSPPPRSAVSLGAASADLESALLFAGLDDRAAAAAAAAAAAADNDVVLGVGETWEDFRYRMLPRGDRADLRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS69</accession>
    <name>F9XS69_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846939.1">
        <property type="nucleotide sequence ID" value="XM_003846891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS69"/>
    <dbReference type="GeneID" id="13396727"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98059"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_20.75"/>
    <dbReference type="HOGENOM" id="CLU_702505_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS69"/>
    <dbReference type="OrthoDB" id="10345644at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="393" mass="43147" checksum="664BA3C0B46E1902" modified="2011-10-19" version="1">MDTDQGRARKEPKEHTRLYRELLDAIEGSKETSTLETVSALFPNLTVKAEPEDETKTSSQVMDTDQGRPRKEPKENTRLYKEVLDAVEGSKETSTLETVTALFPNLTVTAELEDETKTSSHVTPTNGLDRTASSPPREVSSKKMHVFGSEPSKPAHYTPPTSRLNKNESREVGAQHKEEPSSLFRAPSPSYPMLPRPANSKMESDRPSTTQGYRSLDYSTKSSRPAKSKMESDSPSMTQGHRSLDYSTKSSLPAKSKMESDRPSTTQGHRSLDQYPSTQLSQLAYSEMEVKAPSKNVFAIEDWYKGVARTTTPSAGAVVPLFNPTLPSQRTTRKSVAFKSPASVTPSSPGNLFTSHNENRQTPFQQPNAESTISKLVSGEKGDDGADGSEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWH0</accession>
    <name>F9WWH0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SSN3</name>
        <name evidence="25" type="ORF">MYCGRDRAFT_65914</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857428.1">
        <property type="nucleotide sequence ID" value="XM_003857380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWH0"/>
    <dbReference type="FunCoup" id="F9WWH0">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWH0"/>
    <dbReference type="GeneID" id="13394629"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65914"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="F9WWH0"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="CDK"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 25" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGP92404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="46545" checksum="423C0ED6D52C0A5A" modified="2011-10-19" version="1">MSGTPYAPQRHINDNYDIVGFISSGTYGRVYKAIHKRAVSNPPAKHPDGRNIEAFAIKKFKPDKEGEVQYTGISQSAIREMALCTELSHPALIHLVEIILESKCIFMVFEYAEHDLLQIIHHHSLLPRTPIPASTLRSCMYQIFSGLLYLHRNWVVHRDLKPANIMVTSSGAIKIGDLGLARLFYKPLHALFSGDKVVVTIWYRAPELLLGSRHYTPAIDLWAVGCIFAELLSLRPIFKGEEAKQDSKKAVPFQRNQMGKIGEILGLPKKSEWPLLSAMPEFPNLQTVAMHAPNVNRPLGLTKWYRSTVQNNNYGGGGPPDESALDLLRKLLEYDPLKRLTAEQALKHPYFVGGGAESAGGKASTPSWNCFEGLETKYPARKVSTEAHEIATGGGTMSGQKRSVVNDDLGRPGKKAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWX0</accession>
    <name>F9WWX0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_35120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857072.1">
        <property type="nucleotide sequence ID" value="XM_003857024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWX0"/>
    <dbReference type="FunCoup" id="F9WWX0">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWX0"/>
    <dbReference type="GeneID" id="13395397"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35120"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1616"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="InParanoid" id="F9WWX0"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26372" checksum="2AA46D3A26492C06" modified="2011-10-19" version="1">MPHHEDNDFSAPAETHEFSALLFDMDGTIIDSTDAIIKHWHQLGEEIGVDGNEILKTSHGRRSIDVLRLLAPEKATWDYVCQAEGLIPQKWGSSAVEIPGSRSLLARLESLKAPWAIVTSGTQPLVSGWLDVMKLSRPKVMVTAEEVALGKPDPACYRLGAERLGFGTLSEGEEILVLEDAPAGVMAGKAAGFKVLGLATTHTVEQLKEAGADWIVRDLESVSAAKVDAKTGKVEVEIRDALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWX4</accession>
    <name>F9WWX4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_102814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856612.1">
        <property type="nucleotide sequence ID" value="XM_003856564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWX4"/>
    <dbReference type="FunCoup" id="F9WWX4">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWX4"/>
    <dbReference type="GeneID" id="13398855"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102814"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWX4"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="261" mass="29624" checksum="8B0C59EF4126E68E" modified="2011-10-19" version="1">MASPAEQQIHRDPALFYWILLPITVVMILTGILRHYLSTLLQTIPKKQPIGKTRQQRSLAHAQTLRVNYQQISKSAFERRKEVFIEGVKDGRYLADQENRGQPPANPMTDPAMMEGMMGMMKGNVAMMVPQSLIMGWINAFFSGYVIMKLPFPLTPQFKQMLQAGVGTRDLDVRWVSSLSWYFLTLFGLQPVYNFILGSNNAAAQVTQQMAQQQMVTNPMGGQEDPEKPFKAEIENLEVLEHRYILEGIEDRLIAKFGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWZ2</accession>
    <name>F9WWZ2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_89943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857059.1">
        <property type="nucleotide sequence ID" value="XM_003857011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWZ2"/>
    <dbReference type="STRING" id="336722.F9WWZ2"/>
    <dbReference type="GeneID" id="13398846"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89943"/>
    <dbReference type="eggNOG" id="ENOG502T28S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642538_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWZ2"/>
    <dbReference type="OMA" id="REWIDCA"/>
    <dbReference type="OrthoDB" id="5429780at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="48332" checksum="358EA2018E40D8E2" modified="2011-10-19" version="1">MLRPIEDEVWYCPRQSRHWTHCQSAIMVPKNSTELPTEIKSFDTLIYLGLNNERAAELWAKWAENGYRYFDDDQAGPDMTCNCFGCFVRDCLRHWRYFRRADFGDSDVDWRPALRASGANEALIEAIMGTSGTDGIRLTQSTAEWIDNAIMWRWEWLCVVHEAHNGGFDLSNGIHVHAAKSTVPEHDVTNITWNREINRPVKPDGGKTDHIPLWKAVPRVHAEAVWDAERAKAQHWTPDLEFAQMYADYCQKIAGPAPFCLARLEVPNSVFKKHTRKLLQYPSEKWKRVTYASHIRRCAKPESLTQELLRTALLVGDIATGLNSRSTPLKSWEEVSDKHTLKLKSGQRATQFVFDHEFIGRHEDYEEFIDAVNKLESRFTIRDVERPNVILPPIGGFDDESNESLRNVVYVSMLSDVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX17</accession>
    <name>F9WX17_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_67267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856693.1">
        <property type="nucleotide sequence ID" value="XM_003856645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX17"/>
    <dbReference type="GeneID" id="13398099"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67267"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1796"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_1_2_1"/>
    <dbReference type="InParanoid" id="F9WX17"/>
    <dbReference type="OMA" id="FLMGVGH"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="442" mass="48962" checksum="08664DF31C28D76C" modified="2011-10-19" version="1">MSQPKQLHLTAFMRPVSLHTGAWRMPGSFPDANFNLAHLKYFIQKLEAAKFDAFFMADHLAVLNMPTEALKRSHTTTSFEPFTLLSALSQCTSRIGLAATASTTYDSPYHVARRFASLDHISEGRAAWNIVTTGNPESSKNFGEEEHMQHGDRYKRAREFYDVVTGLWDSFADDAFVRDAESGMYLDPEKMHVLDHKGDELNVRGPLNIARPVQGWPVIVQAGQSEPGKQLAAETAEAVFCVPKDLEGAKVLYADIKARVKAAGRNPDHLKLLPAAMIIIGDSVEEAQARRLKLDSLVHYDSAIASLSINLGTDASKLNPDGPLPDDLPATNASHTARQSVEKLAKEEGLTVRQLAQRLGGYSGLAFVGTPESIADDFEQWLKEGACDGFTITMPYLPQGLEDITDRLVPELQRRGLFRKEYEGTTLRDHLGLPRPRNQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX54</accession>
    <name>F9WX54_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856977.1">
        <property type="nucleotide sequence ID" value="XM_003856929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX54"/>
    <dbReference type="GeneID" id="13398688"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90092"/>
    <dbReference type="HOGENOM" id="CLU_2199076_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX54"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395408" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="592CBE84DB18DDBD" modified="2011-10-19" version="1">MLVLAASARIFILAFFIITTLGKQQTRKPRVICALKKDNICVNWAVYGVGKMSQSELTAVEDDCQQKCKDKGQACEAKVVSVDTWNYRCVPFCKREECREAFSGKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXR0</accession>
    <name>F9WXR0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857638.1">
        <property type="nucleotide sequence ID" value="XM_003857590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXR0"/>
    <dbReference type="GeneID" id="13403209"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88928"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.400"/>
    <dbReference type="HOGENOM" id="CLU_2160404_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXR0"/>
    <dbReference type="OrthoDB" id="3816007at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="111" mass="12685" checksum="D7D1F5DDE9C9FF7D" modified="2011-10-19" version="1">MECKECGNRHDSSVIFWGGDEVKRRVVGNTWAVERGASRPNEFYRSPVIEDILRRCRGLGFQVYVKESYEAGDWMHEMDRNASGTPCDDAPLTRQYAVFLPKDAPKDREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXV8</accession>
    <name>F9WXV8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_65617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857529.1">
        <property type="nucleotide sequence ID" value="XM_003857481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXV8"/>
    <dbReference type="GeneID" id="13394374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65617"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.619"/>
    <dbReference type="eggNOG" id="ENOG502R2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_1_1_1"/>
    <dbReference type="InParanoid" id="F9WXV8"/>
    <dbReference type="OMA" id="AMIAMSH"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="362" mass="38833" checksum="37F17F1CBFC91949" modified="2011-10-19" version="1">MASNQGQYFPPPPPSQEGQDQQQFRPPPIGGQQNFYPPPQQQQQQEHAQPHFAPPPSFAPPPAVSPISTQDAAPTPPPAQTGTALPYYPGPPSSQSYHDEKQPEPAASSNRQSINRQSSVAGGAPAPGHFVGAQATTADDVGTFNGGSYRISHRDTNTIVTIQLAMGCPMEVKPGTMIAMSPTITVKGNFKFSMKKLLARGEMSHSTFTGPGELLLAPFALGDITNLRLSGKEQWSVGKDAFLASTQGVTKTYVSQNFSKAMFSGEGFFIYKIAGVGICWIQSMGAIIRKDLRDGEKYIIDNGHLVAWNCDYVLERVASGGIISNLSAGEGLVCKFTGPGTVFMQTRNPQQFAQYMAAHTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY57</accession>
    <name>F9WY57_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_66426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856393.1">
        <property type="nucleotide sequence ID" value="XM_003856345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY57"/>
    <dbReference type="FunCoup" id="F9WY57">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY57"/>
    <dbReference type="GeneID" id="13394950"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66426"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013399_0_1_1"/>
    <dbReference type="InParanoid" id="F9WY57"/>
    <dbReference type="OMA" id="TMGNFYA"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="136"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="517" mass="56705" checksum="2A5DAE7FF4F18342" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD5</accession>
    <name>F9WYD5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_67117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857049.1">
        <property type="nucleotide sequence ID" value="XM_003857001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYD5"/>
    <dbReference type="FunCoup" id="F9WYD5">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYD5"/>
    <dbReference type="GeneID" id="13395413"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67117"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1666"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="F9WYD5"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="22570" checksum="CD1AFF0DD76C4E49" modified="2011-10-19" version="1">MGISRDSRHKRSASGAKRAYYRKKRAFEKGRQPANTRIGAKRVHLVRTRGGNRKFRALRLDSGNFSWGSEGIARKVRVIAVAFHPSNNELVRTNTLTKSAVVQVDAAPFRQWYEAHYGAALGRRRQQKAEEEVKKSKSVESKQKERHTAQGKVESALERQFEAGRLYAVVASRPGQSGRVDGYILEGEELAFYQRAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYI3</accession>
    <name>F9WYI3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_33394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856975.1">
        <property type="nucleotide sequence ID" value="XM_003856927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYI3"/>
    <dbReference type="FunCoup" id="F9WYI3">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="GeneID" id="13398116"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33394"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYI3"/>
    <dbReference type="OMA" id="GLWFFNS"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="173"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="31065" checksum="7CF16B3E4D147712" modified="2011-10-19" version="1">MNDTHWLARFDELVKSGAVSYDANQETIEHIEGDLKVPLTAKPHTISSPTSTSNPSPTLRPGSDISTTGYELTPIGPQHFLAINKFSYARPHLMLLTSDAHRRQHEPLSLSDLAAAWTLLTLAVENDYMVFFNGGKEAGCSRAHKHLQMLPLPKHSLAAFLDSDEDEEGGVEPAVSFQWVWQRFGKGDLITPEGLKEAYDALMEKAEACCGRKEDAVEGAACPHNFLLTKRWMLVVPSGISKEVGANSMGVIGVLPCTTRADMEVWKEVGVGKGLAMIGVPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYJ1</accession>
    <name>F9WYJ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_31803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856713.1">
        <property type="nucleotide sequence ID" value="XM_003856665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYJ1"/>
    <dbReference type="STRING" id="336722.F9WYJ1"/>
    <dbReference type="GeneID" id="13398119"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31803"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1854"/>
    <dbReference type="eggNOG" id="KOG0558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_1"/>
    <dbReference type="InParanoid" id="F9WYJ1"/>
    <dbReference type="OMA" id="TPIFMEA"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP91689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 115943 / IPO323</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1093" mass="120364" checksum="AB92A1FD39D85027" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ79</accession>
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        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    <dbReference type="InParanoid" id="F9WZ79"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="84" mass="9857" checksum="394DC882E0AEDE0B" modified="2011-10-19" version="1">MDWYLEHPEESQKIANNSIATFRSKYFTPAATSCYLRRLIKGYGEVAFTPEVLRPEKRGEARKRRGMSFAEIVHLREEYEGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZR7</accession>
    <name>F9WZR7_ZYMTI</name>
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        <submittedName>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857605.1">
        <property type="nucleotide sequence ID" value="XM_003857557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZR7"/>
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    <dbReference type="GeneID" id="13403985"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88982"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.460"/>
    <dbReference type="eggNOG" id="ENOG502SPQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277090_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZR7"/>
    <dbReference type="OMA" id="FTLTMCE"/>
    <dbReference type="OrthoDB" id="3642826at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391033" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1146" mass="116913" checksum="4A89F955B835F055" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZZ4</accession>
    <name>F9WZZ4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_107068</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856166.1">
        <property type="nucleotide sequence ID" value="XM_003856118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZZ4"/>
    <dbReference type="STRING" id="336722.F9WZZ4"/>
    <dbReference type="GeneID" id="13403057"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107068"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.720"/>
    <dbReference type="eggNOG" id="ENOG502RXRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738119_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZZ4"/>
    <dbReference type="OMA" id="REICETP"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
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        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41997" checksum="F738FDCE0E415513" modified="2011-10-19" version="1">MSLVNLANVCSHLQNASLARLGLTSIPYTKWHLSLALLLQKQGFLSQVKLGGASPPASCFAPGPRDNHHVSNHPQGAAGRNPRSPEAALALTVRHGMTRTQLRGMGFTHEALEFAQQHSRRSLEDLEAQGWPQQVVRFIADIRAQIEALEEERRSDIERERYEQQTRVRWEAGESTSRFAGDREAELTPEALQEDVLKHLSPEQREVYIRYSNVSQEELSQVRFDFDTLAAVAGKYALRTELDIKRGGITISAMGLDIPNQSVTLPKEAFEDPKMLDAEGVVTQENRASRRLWLGLKYYESSPVLSKARMISKPTKRILLSSRDLGRVVRGHQAGEVKPLTQIGEIMAVSTDKGIMEARECAERRIGGMPLCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZZ5</accession>
    <name>F9WZZ5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_89185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856167.1">
        <property type="nucleotide sequence ID" value="XM_003856119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZZ5"/>
    <dbReference type="GeneID" id="13394496"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89185"/>
    <dbReference type="HOGENOM" id="CLU_1950513_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZZ5"/>
    <dbReference type="OrthoDB" id="10534147at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="129" mass="14491" checksum="8AA5ACAB6CEAF818" modified="2011-10-19" version="1">MSATIILCNTPIYIMTTGSRPPSDPIPARRFTTSAALHAHLRSHKRFVLSWTVFRQHLTDHCAFDSATDAVVYAKEPAFEAKMVRNEAELNEAFREMRNGRGGVGFWVVRGDVFANGFLASAKQVEFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0K6</accession>
    <name>F9X0K6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_35119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MAL31p Maltose permease"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="483"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="521" mass="57614" checksum="0DCE6EEEA5CD6BED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0L1</accession>
    <name>F9X0L1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857015.1">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391186" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="159" mass="15365" checksum="C414C1CAA5373B62" modified="2011-10-19" version="1">MRASTIFALIGSAIMVSGAAIPVEQKRDAVAYAVPSEQMDQLTKILGSIVGNGNGNKDNGIGNGNKDNGNGNGSGNKDNGNGNAIGNPGSGNKDNGNGNSIGNGFGKGAGAGAGSGNGNGNQAGNGNTFGNGNDLGSLDLGGILNGSGNVRPVINIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X150</accession>
    <name>F9X150_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X150"/>
    <dbReference type="STRING" id="336722.F9X150"/>
    <dbReference type="GeneID" id="13394908"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89490"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1083"/>
    <dbReference type="eggNOG" id="ENOG502SC4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066893_0_0_1"/>
    <dbReference type="InParanoid" id="F9X150"/>
    <dbReference type="OMA" id="WIASRWK"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="235" mass="26816" checksum="6A7869438A5636FD" modified="2011-10-19" version="1">MSLLRSSRNILLKNLPEELVLRILTFLDIPDLLATSRTSHQLRTLSLDSVLHTHRLRHSHALVSTLYPLRPHLSTLQPPTSTIYLTAVHNRARILHWSLVRARLNRSLIRRPALSDLVSANILPPECCRLDRRSGEFVWGAGLAGALVEPKRRLEREYLKEGLRALLERKVRRIGARRKESGGGVGVMVWRFSRKLKLGEGRREGDCDRSGRVRDVGLKSDGKVMSLKRFFEGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X163</accession>
    <name>F9X163_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor SipA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_98644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003857154.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X163"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98644"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="InParanoid" id="F9X163"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor SipA3"/>
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        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="307"/>
            <end position="408"/>
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        <location>
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            <end position="1070"/>
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    </feature>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92178.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="150047" checksum="90D0F28435937670" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X192</accession>
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            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015179">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="394"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
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            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="535" mass="58764" checksum="5A6133F733DCC11F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X243</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854815.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X243"/>
    <dbReference type="GeneID" id="13396000"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107916"/>
    <dbReference type="eggNOG" id="ENOG502SF0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687375_0_0_1"/>
    <dbReference type="InParanoid" id="F9X243"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="401" mass="43573" checksum="3313506C804415BE" modified="2011-10-19" version="1">MSTHTTSLSNADLRSNSQPYKRDAAHKHKWALGAVERNQREGGAEGKAKPVKPFPTNIHNSRRRHTATALAASAAKSAKFRPAHPTSDDHPALSSSPSSGSNSESTSDLEADAPEAAEITYTYDHPGGPVAASEILTAALARAVERFEDAETVRLVKGEWDVLDEEGEVVRIGKGGKAVGGGGKKMVAPPTQGGVKARDVDEDWEVVGTLAWPAYAALGGVQFGVVKAAHGRERFDDSTRDLLMVEGRSPLVAIAQCFHRGGEGFHRVVKIWAASANRVVPSILSVTNDRDKSQAQRDDLRHHYLAIPTSLGRYSMLLSRVKKTKFEVCAKGRGIWPPLSSTLHGVARCTLLALKLATLHFTSFDIYSIPEVFSFQRRTPHEDGSGRRIFDSCLRLRFDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X260"/>
    <dbReference type="GeneID" id="13403638"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90532"/>
    <dbReference type="HOGENOM" id="CLU_816850_0_0_1"/>
    <dbReference type="InParanoid" id="F9X260"/>
    <dbReference type="OrthoDB" id="3650888at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395280" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37463" checksum="7E3EA644F970C1D7" modified="2011-10-19" version="1">MVLKSLLMSALLIVPTHAQSSSLHNSSIPTAPRSETSPSLPITSSGLEQTGTTKAVTLEPPKTSCPAGTTTVKSCWTGYTIQWTSKPGQVRYSSAILVQSAPGGSAGIPHKRHHIKYIVFENFNDHDHKYSGGPCDDSLIRVTFTHSRKASWLDVCEQHNVSSLLGHQRFATPVVFTTTLPEFKGGNDLGNVIRKCHDVSRFPGHGDLSGRAQRIFAVDTCEEGRKVELSSKGERIAERKFNQESFVNYDFYIHWIPGCRLKNADGKLVDRQKVDFKTTSDNKDPSTVHNSACMAYFVSTYKQCNNEGVGGSIEAGCLKYTFTGGRFEVLIDYWNTVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2G6</accession>
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        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase protein</fullName>
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    </protein>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855023.1">
        <property type="nucleotide sequence ID" value="XM_003854975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2G6"/>
    <dbReference type="STRING" id="336722.F9X2G6"/>
    <dbReference type="GeneID" id="13399814"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90887"/>
    <dbReference type="eggNOG" id="ENOG502RWEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011082_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2G6"/>
    <dbReference type="OMA" id="HSYALMG"/>
    <dbReference type="OrthoDB" id="2624308at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="32"/>
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        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="94865" checksum="872665C1B1CD6DEE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J7</accession>
    <name>F9X2J7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIID complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GTF2401</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_67750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854726.1">
        <property type="nucleotide sequence ID" value="XM_003854678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2J7"/>
    <dbReference type="FunCoup" id="F9X2J7">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2J7"/>
    <dbReference type="GeneID" id="13395895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67750"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.88"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2J7"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="261" mass="28431" checksum="926540E51283A60A" modified="2011-10-19" version="1">MDQVYISHPQNAAEAKQFAAPQSLSFPGAQGHLTPPNESQQASKNGMNGQQQGGNAVQPAQGNGVTPATPAATPGQAGTGVSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHMFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2Q8</accession>
    <name>F9X2Q8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_35535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854833.1">
        <property type="nucleotide sequence ID" value="XM_003854785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Q8"/>
    <dbReference type="GeneID" id="13403614"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35535"/>
    <dbReference type="eggNOG" id="ENOG502RKCZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_2_1"/>
    <dbReference type="InParanoid" id="F9X2Q8"/>
    <dbReference type="OMA" id="CIDHIRQ"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="167" mass="18914" checksum="7E6E97F210249584" modified="2011-10-19" version="1">MYAGESRPELEDAWDDLMRAEVFRATAEDLSLDDEAVNDAVTLEHGGYLASLSVYHALHCIEWIKRNYARAHTIDELHGKEGHLDHCLYFIRESVTCRADVTINSFHWGEDSDVPLSLPGKERPCVDLAAVREWILERALKPGERAVHTNGSLGAPHNKYRFEMPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3B7</accession>
    <name>F9X3B7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_35809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855770.1">
        <property type="nucleotide sequence ID" value="XM_003855722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3B7"/>
    <dbReference type="GeneID" id="13403710"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35809"/>
    <dbReference type="eggNOG" id="ENOG502R995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025638_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3B7"/>
    <dbReference type="OMA" id="CDHYPHP"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="416" mass="47909" checksum="E4D20A19550405D4" modified="2011-10-19" version="1">MIDSFLGLAPVRTAREATIAIKHGGRFPSDRNGKVKDLPIIDVVIVAYLPNEKDIIRQQVLYACKRLVYPKDKLNINLVYNTPIPIEPLESELARLPQQYKTLRIIKAPGSTSKADNLNYFFTLKSNADIIGIFDTDHCPHPYNPRWAAERFLADDTIDIVQGRCIVYNTSESFYAKMISIEFDRIYAISHPGRRQMFGLGLFCGSNGYWRAPLLRKHKMDGSMLTEDIDSALRAYGLGKQIVHDMNVVSFETAPNTFAAFWRQRLRWAQGWSQASIKHMPLLWTNPPNGNRGFNERLGLFSLLFVREISHHLIAQHVCLLVSFLITDWPSDLSELVRILFFRYPTAGWFFWATFIAVLLTLYFTEQVRSRYTTTWQMAIFSLLHVPYLVLVAVIGLYGHARQLVKYDKWNPTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3N3</accession>
    <name>F9X3N3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_99133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855536.1">
        <property type="nucleotide sequence ID" value="XM_003855488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3N3"/>
    <dbReference type="GeneID" id="13403476"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99133"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.607"/>
    <dbReference type="eggNOG" id="ENOG502S8YZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3N3"/>
    <dbReference type="OMA" id="HEDFVWK"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37929" checksum="2902B3ED5D214167" modified="2011-10-19" version="1">MTEPELADLIPKPQFLQDLEQDGFVVVPNVLPKPSCDEFVEQAWEWLESASHGFRRDDRSTWTAEHLPYGHDRGLYNRYCVNHEAFVWRIRSHPGILKVFSQVWGTDDLIASFDGINISLPVNPEVGRTDIAATKPWPHIDQNPRTIDKLELYQGIANIAPNGPLDGGLVVLSGSHKLHTEHFDSTGGFRAHQDSGLAENGYNFLPEDVAWYHRQGCKQVKICANAGDLILWDSRTIHWNCTPTQSQTRFAAYVCYCPRSRMSDEDLKTKSEIFDLRKGTTHWPNKNIVPADRPGYHYAKPRRPDDSLDSANRERPFNEPHVTPSVLSLVGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3P3</accession>
    <name>F9X3P3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854957.1">
        <property type="nucleotide sequence ID" value="XM_003854909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3P3"/>
    <dbReference type="GeneID" id="13399597"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103262"/>
    <dbReference type="HOGENOM" id="CLU_2591616_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3P3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="9010" checksum="D9497938D37AEA75" modified="2011-10-19" version="1">MRYDFWQSEMLNSERSCFALRLRGSTGIRILLRGCIGYVWPESATYGTEATSGPKGGWEQIETTLGLRRLIGEAFTAKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3R5</accession>
    <name>F9X3R5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855521.1">
        <property type="nucleotide sequence ID" value="XM_003855473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3R5"/>
    <dbReference type="GeneID" id="13403461"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90801"/>
    <dbReference type="HOGENOM" id="CLU_963799_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3R5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="289" mass="30163" checksum="A77FB15597DBCF67" modified="2011-10-19" version="1">MSTSMAATALSDQALITASPTLDMPAPRGSVGSLTAVPSDNKPISTIDGADSLITDGPDAPSGQVSSADGLPGSPNGSPSKGLSFEDKLGLGLGLGLGVPVVFALLAFLILYVRRRRRHRINQMQADLLPTRGLVCKVQSELPMVETPNARVSSVMPRSADGPKYEPVRVPFIGPRAGLSDDDFEDRENDHGHAVSSPTIVRPPVIPRKPINSIVAPIESIEGPIHDIAIDQPGGDRRSRASLGKLDIPSPPILGHARVSPVSPVSPVSSRDDAESSAGRGRRDVSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V1</accession>
    <name>F9X3V1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-Ig-H3/fasciclin cell adhesion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_14838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855065.1">
        <property type="nucleotide sequence ID" value="XM_003855017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V1"/>
    <dbReference type="STRING" id="336722.F9X3V1"/>
    <dbReference type="GeneID" id="13399856"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_14838"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_2_1_1"/>
    <dbReference type="InParanoid" id="F9X3V1"/>
    <dbReference type="OMA" id="FKGYYPA"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="383" mass="40043" checksum="A0161CB8CC923A14" modified="2011-10-19" version="1" fragment="single">LSALASLAFAQGDLVALLQSQPDLSTLLDFVQLVPGLANTLSQATNITIIAPTNQAFDNVPTEVPEGQAIVNRNVSSIEGLLVNHVFAGYYPSSLLSEVPTFAQTLLNTSYRNEFQPFTETPSGQYNGLVLNGENVNILSGELTVSNVIQGDIMLGEGIVIHVVDTAMSFAPPLQLFTARADLLAYNGALEAADLGLDVGLEEDGGPVNTFTDITFLVPNDLAFQAIGSVVDSVDQATLAQVLEYHIIPDNIVFSPSITNASVASLQGNDLVFSVLPNGEIFVNGAKVLFANVILSNGVAHIIDSVLNPASAPFDRASLDAAAPASDRIAFPGATPSDDLPITRSLSFASEAIAQTIPTPEILKTLSLVAVTPTSASTVPTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4H2</accession>
    <name>F9X4H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_68510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854989.1">
        <property type="nucleotide sequence ID" value="XM_003854941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4H2"/>
    <dbReference type="FunCoup" id="F9X4H2">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4H2"/>
    <dbReference type="GeneID" id="13403439"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68510"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.684"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="InParanoid" id="F9X4H2"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="416" mass="46270" checksum="7BE452C08A3A65D4" modified="2011-10-19" version="1">MAKGKVCLAYSGGLDTSCILKYLLEEGYEVVCFMADVGQEEDFAAAKEKAMKIGASACYIEDLRREFIEELCYPAIACNAIYENVYLLGTSLARPVIARAQIAVAQKEGCFAVSHGCTGKGNDQVRFELAFYALQPTIVVLAPWRDPVFYNRFKGRNDLLDYAASTGIPVTSTKSKPWSMDENLAHCSYEAGILEDPNTSPPEDMWKLTVDPTKAPDTPEDFTLHFSKGLPVKLEYDGKTVTDSVDLFLAANAIARKHGVGRIDIVENRFIGLKSRGCYETPGFTMLRAAHIDLEGLVMDREVRALRDQFVTFNYAKLLYNGLYFSPEREFLEASITESQKKVNGSVRCRAYKGMFSVMGRWSDTEKLYDESESSMDEIGDFAPSDTTGFISVNAIRLKKFGKAKEADGISLVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4N1</accession>
    <name>F9X4N1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_35719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855050.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="13400934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35719"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.917"/>
    <dbReference type="eggNOG" id="KOG1992">
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of protein export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP90074.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="963" mass="108374" checksum="817948C1F6CB873B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4W9</accession>
    <name>F9X4W9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_36358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4W9"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X4W9"/>
    <dbReference type="GeneID" id="13400491"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36358"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1203"/>
    <dbReference type="eggNOG" id="KOG2904">
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    </dbReference>
    <dbReference type="InParanoid" id="F9X4W9"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41038" checksum="D34BDD673F7BF07E" modified="2011-10-19" version="1">MPRIHPSVFAKARAINKSLVPLIPVCRDLGSARNELRWLKEHAVSVSKQLGHGEHETIVDGYLRRRARGEPLQYILGTEFFGNLEIRCRPGVLIPRQETAASISHLANLLASDQTLTNESNSTLRVLDLCTGTGCIPLLFHHELYTSNASTSTTLELVGVDISTSALSVARENLIHQIAHAARAQPTAHSKRTRSLNQIGFVQADILASSPSTESSGPLPLNEALGRLYSGETEPPTFDILISNPPYISPSAYLRTTTRSVRNFEPKLALVPPSPTPSSSGDDETIGDAFYPHLWRLAEQVKAKVCLFEVSDLQQAKRVAAMAVEHGKWDVVEIWRDEPGARSEAVEELHVGGRSVGVRGAGNGRSVFARRGIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5R1</accession>
    <name>F9X5R1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_39488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854392.1">
        <property type="nucleotide sequence ID" value="XM_003854344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5R1"/>
    <dbReference type="FunCoup" id="F9X5R1">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5R1"/>
    <dbReference type="GeneID" id="13395578"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39488"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5R1"/>
    <dbReference type="OMA" id="WERADIF"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30999" checksum="732F861287AC7938" modified="2011-10-19" version="1">MAKKKLVVCGGNGFLGSRICKAAVARDWDVVSISRSGEPNWPSVSAHQTAPAWSKSVQWRKANILQPETYKSDLDGANAVVHSMGILLEADYKGVLTGKESPIAGLRRAFSATKAGGNTNPMDRKPGQAIEPGEKDGQITYELMNRDSAIALAREANDSGVKAFCYISAAAGAPILPGRYINTKREAESTVSSAFPRMRNVFIRPGFLYDSSRAFTMPMAAVTYGGFLANSLTGGNLTWLMGAGGSKPLKADLVAEAVVESLSDDTVKGPVEVKEIEELANRAWRRNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5S0</accession>
    <name>F9X5S0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_69926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854387.1">
        <property type="nucleotide sequence ID" value="XM_003854339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5S0"/>
    <dbReference type="STRING" id="336722.F9X5S0"/>
    <dbReference type="GeneID" id="13395573"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69926"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.598"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_3_0_1"/>
    <dbReference type="InParanoid" id="F9X5S0"/>
    <dbReference type="OMA" id="HAKTARW"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="420" mass="46056" checksum="2DE5F6EEAEB792D5" modified="2011-10-19" version="1">MARPTTSNPLELDGRTLEGGGQLIRIALCLSALTGTPIRISNVRGNRSGGGGLKAQHIACVEWLARACNATVHGATKGSQTLLFQPGRYEGELSPVFTKRTLDDGRQVYECRVDMTSAGSTALVLQAILPFILFSRLPSRLPIHLHLSGGTNSSGSPSFEYITYVLLPTLHRIGFPEMKATLGQRGWSQGATSIGDWTLEIPPRSSLMLPTFTYQPTDPSIPPSLPSHLHAIFLGPAACHDQVSALLLPQIHQHFSPYFTTSSSNFTLTLHDSHHPKRIYFILIATIPSSSSSSVSSTYTLARDNLQLRKFPTVPIILSQILPRVTAELASDWRSGAWVDEHMRDQLVIFQALAEGRCGVFPGRREEDVDLREPSLHARTAEWVARSMLGVRFDAQGVCEGVGFEGEDVLVERLEKLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Y4</accession>
    <name>F9X5Y4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_91335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853639.1">
        <property type="nucleotide sequence ID" value="XM_003853591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Y4"/>
    <dbReference type="FunCoup" id="F9X5Y4">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5Y4"/>
    <dbReference type="GeneID" id="13400894"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91335"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.61"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="InParanoid" id="F9X5Y4"/>
    <dbReference type="OMA" id="CISNGEA"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="257" mass="28091" checksum="3FFF3CC7395E4AE9" modified="2011-10-19" version="1">MAPQPTTPGVTINAAGKKSFIPLENNPEVFTSLMHNLGVSSKLTCHDIYTLDRSFLATIPRPVHALIFIAPGPVYHRVRARHDGGTGSGSRVDEHITYDATGPDEPILWFRQTIGNACGLYSLVHAVGNGSARAHVQPDTLIDRLLKQAEPLHRVKRAAVLYDSLELERVHMAAAVEGDSHAPESQEKVGYHFITFVKGKDGHLWELEGSWDPIDRGVIEEGEDLLSERVVEMGVGKFVEEAEGNVGFSVVAVVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X610</accession>
    <name>F9X610_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_91361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854638.1">
        <property type="nucleotide sequence ID" value="XM_003854590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X610"/>
    <dbReference type="GeneID" id="13395824"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91361"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.90"/>
    <dbReference type="eggNOG" id="ENOG502S5JG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861101_0_0_1"/>
    <dbReference type="InParanoid" id="F9X610"/>
    <dbReference type="OMA" id="LGANCYA"/>
    <dbReference type="OrthoDB" id="3650646at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390147" evidence="2">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="32407" checksum="0D0A27E934821B24" modified="2011-10-19" version="1">MRSTLLTLGLVAMSVSAQKDNGQKDDQKGAVPQWTTDNPNPACENDYNTCISNPSNRHDQCECLHQACQNNDSNGPSHCAQVLNLPASLAAGPLPNQYKPTSGISPIPNQPMPTTTAPNGDNIIVGTLGPAPGGGSPIAAPANSIPLGQPCSDDRQCAGQGVACFGQTSGTIPSCGSFNAPCQRDDQCAYNTCDQKIHLCAGFLPSQSQLANRPAATTGHVAGVPTGTPPGNGTPGEATAPMTTTTVVRPELSGSLGPNYVPTANGTLVGTMTGPGGARATVSGIRGNATTSAKPGVSTGGASSMGVFSGVAAVGFGILAWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X637</accession>
    <name>F9X637_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_69545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853734.1">
        <property type="nucleotide sequence ID" value="XM_003853686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X637"/>
    <dbReference type="FunCoup" id="F9X637">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X637"/>
    <dbReference type="GeneID" id="13395716"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69545"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.300"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="InParanoid" id="F9X637"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
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        </source>
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        </source>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Dehal P."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59106" checksum="B9C8B2D741327E1B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6L7</accession>
    <name>F9X6L7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_69322</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="non-terminal residue" evidence="5">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
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    </feature>
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        <location>
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            <end position="711"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="760"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89111.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7W5</accession>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854307.1">
        <property type="nucleotide sequence ID" value="XM_003854259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7W5"/>
    <dbReference type="SMR" id="F9X7W5"/>
    <dbReference type="STRING" id="336722.F9X7W5"/>
    <dbReference type="GeneID" id="13404309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108743"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.789"/>
    <dbReference type="InParanoid" id="F9X7W5"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="468"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="822"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1053"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121573" checksum="D523A258202993DE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X828</accession>
    <name>F9X828_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_39363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003854098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X828"/>
    <dbReference type="GeneID" id="13404486"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39363"/>
    <dbReference type="eggNOG" id="ENOG502S6PP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_0_2_1"/>
    <dbReference type="InParanoid" id="F9X828"/>
    <dbReference type="OMA" id="VYVVRWM"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23950" checksum="8AC46ECBD70CA4E0" modified="2011-10-19" version="1" fragment="single">AMSTTWPPAEGLCSPTVSRKDAVFSIYASTTISASAASVLETVLNVSSYPQWNTFIPKASITSQPADSDSPDDHSHMQVGSIMTFHAVMNSSKPQSATETSLQVTDISTPEKKSTYISQETLDSEPAYTADLDKVYRVCWKSYGGFASRGLRSERFHEIIVKSENECEVRTWEVMGGALANVVKWMYHKTLQQKFRLWVDDLKKYCEGGQAVPSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8K2</accession>
    <name>F9X8K2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_109284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853130.1">
        <property type="nucleotide sequence ID" value="XM_003853082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8K2"/>
    <dbReference type="FunCoup" id="F9X8K2">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8K2"/>
    <dbReference type="GeneID" id="13399770"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109284"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.750"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="InParanoid" id="F9X8K2"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="702" mass="78265" checksum="C34901428998A72A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9X987</accession>
    <name>F9X987_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MYCGRDRAFT_104327</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X987"/>
    <dbReference type="GeneID" id="13399734"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104327"/>
    <dbReference type="HOGENOM" id="CLU_2365442_0_0_1"/>
    <dbReference type="InParanoid" id="F9X987"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="96" mass="10582" checksum="575D5CE2E97CF9BC" modified="2011-10-19" version="1" fragment="single">MRGVSLLDTWLHSFVLVEVSKNSYGRGIELEGLITIDCLAMWNTLYAGSEDLAAADRTANWHIHFKGGIEIGHGSTSILQCHIRTHNVSNAVFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9B8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92349</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852871.1">
        <property type="nucleotide sequence ID" value="XM_003852823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9B8"/>
    <dbReference type="GeneID" id="13400659"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92349"/>
    <dbReference type="HOGENOM" id="CLU_1225618_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9B8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="226" mass="24856" checksum="72A2F4C46303BD18" modified="2011-10-19" version="1">MELKENRDGQSKGGQKREQKVGRRVASGKGNEEYGLGACVSVPLYPEATRSAKVAVADDNLSTTEEILAKFARQEKSDRQVAAIRDLTEKKRAAKKTSDSAGINEDDAGAEVGDGLEADREIKTEEDEYMTAEEASTGSLATTSGAVEGYNSNGDAEYRRGQATVELVLESVPVLTEEQIRHKAKLRKRKEKRQAIQKANEDWKKAQKKGKGKKTRRDAGIKQEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA52</accession>
    <name>F9XA52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_71103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853429.1">
        <property type="nucleotide sequence ID" value="XM_003853381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA52"/>
    <dbReference type="GeneID" id="13397301"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71103"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="F9XA52"/>
    <dbReference type="OMA" id="FWILFFW"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="485" mass="54221" checksum="AEF625B180368EA2" modified="2011-10-19" version="1">MPFTVSRFFAAASLIRARPRALRKMDKLERKFVFKLDLFIMVYCCLCYFFNYLDRAAFPNAYVSGMKEDLNLEKNQYSILLSMFTAGSVVAQIPHSLIIQKVPMRIWLPLNLVLWSGITMCSAACKTYSQLCAVRFLQGASEAVVYSGSMYVMGSWYKPSEIAKRAAIFTAVGQIGSMFAGIMMTAMNKSLHSNAGLKGWQWVFIINGLMAMPVAVFGFLFFPDLPETTTVTYFSDDEIKFAIGRLPPKKKDTHKIEWRSLLGRVLKQPHIYLLVGLSIFASMLEAFAFQGLYLLWLKYNKSRFNQTAINSYPLGIQGVAIVSQILAGWFIDSTNKRIPIVILSAALQFVVAVILLQRNMSDAGVMTAFYLSGTSYMVNPTMYGWASTICQRAGDDAVRSVILYAMSMGGLLLYTFWGIVMYPATDVPYWQKGSIAMIIACAFFVASGFSVQWVCDSPSISSASAHADRSLARHKNKGRRCDFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAA6</accession>
    <name>F9XAA6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein scd2/ral3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MgBem1</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_71474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853106.1">
        <property type="nucleotide sequence ID" value="XM_003853058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAA6"/>
    <dbReference type="FunCoup" id="F9XAA6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAA6"/>
    <dbReference type="GeneID" id="13399319"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71474"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.690"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_1_0_1"/>
    <dbReference type="InParanoid" id="F9XAA6"/>
    <dbReference type="OMA" id="FICAHHN"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="38"/>
            <end position="102"/>
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        </location>
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            <begin position="505"/>
            <end position="593"/>
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    <sequence length="595" mass="65975" checksum="5A852346AD16A463" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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            <end position="634"/>
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            <begin position="350"/>
            <end position="360"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Canto-Canche B."/>
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                <person name="De Wit P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
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        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
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    <dbReference type="InterPro" id="IPR027268">
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        <property type="entry name" value="TPR_TAF2_C"/>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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            <begin position="575"/>
            <end position="751"/>
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            <begin position="756"/>
            <end position="1050"/>
        </location>
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        <location>
            <position position="1180"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87365.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133445" checksum="7A042F209C3B3C67" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB77</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_109393</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="220"/>
        </location>
    </feature>
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        <location>
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            <end position="787"/>
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    </feature>
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        <location>
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            <end position="528"/>
        </location>
    </feature>
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            <end position="570"/>
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            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="860" mass="95916" checksum="BE9F4F96908EE9F3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC14</accession>
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        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">MYCGRDRAFT_42271</name>
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    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
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    </reference>
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        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the NXF family.</text>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42271"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.345"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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    </dbReference>
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        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
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        <property type="entry name" value="NXF_fam"/>
    </dbReference>
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        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NXF_NTF2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L domain-like"/>
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    </dbReference>
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        <location>
            <begin position="368"/>
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        </location>
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    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="586"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="642" mass="70752" checksum="E26BFE4026976284" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC16</accession>
    <name>F9XC16_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852497.1">
        <property type="nucleotide sequence ID" value="XM_003852449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC16"/>
    <dbReference type="GeneID" id="13396820"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93442"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.652"/>
    <dbReference type="HOGENOM" id="CLU_2028548_0_0_1"/>
    <dbReference type="InParanoid" id="F9XC16"/>
    <dbReference type="OMA" id="KERQNTC"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391277" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13391" checksum="937A7D9EBCA80560" modified="2011-10-19" version="1">MHFFAACTCLWLVAPMVFADFALDSPALNAQQFPIGLPQDGPLTLTRTTTRTRYDFEYHTLTMTEETSIPAQTTAEHANEATDPGTASCGETACAVCRWTSSECEYGTTECHECDAKAYCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCB9</accession>
    <name>F9XCB9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_86102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852618.1">
        <property type="nucleotide sequence ID" value="XM_003852570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCB9"/>
    <dbReference type="FunCoup" id="F9XCB9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCB9"/>
    <dbReference type="GeneID" id="13396940"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86102"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="F9XCB9"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="168"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="239" mass="26354" checksum="2FD1BE85E3AB12A8" modified="2011-10-19" version="1">MATAAKKELRSRMRETLSRLSDEDIASQSAEAQRTIITLPQFQQADRIGIYLSMPNSEAQTDTLVKASLLSGKSVFVPYIYSVGVEKPKRKVMDMLRLESLDEYYVLDRDAWGIPKLPKEGRESRENAMGGAGLSIAADGSEREFGDEKRGLDMIVVPAVAFDRSMNRTGHGAGFYDRFLTRFCKSKARNKPFLVGLCLAEQALCAGEELPMEQWDWKVDAVAVGNGTGGALLTCDSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCG2</accession>
    <name>F9XCG2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_42685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852359.1">
        <property type="nucleotide sequence ID" value="XM_003852311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCG2"/>
    <dbReference type="GeneID" id="13394136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42685"/>
    <dbReference type="eggNOG" id="ENOG502SHP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039079_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCG2"/>
    <dbReference type="OMA" id="INTHRVH"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32270" checksum="BF7366B31EF8DEBF" modified="2011-10-19" version="1">MVSIHNSGWRTLITLGSSAPAIGKITVAHGKQNKGYQQALSTHLAHAKVHQYPMFLLNHKLIDGLWNKEAALLDVVLDQLTRSKSERLEWLVWVDADTVVMNKQIPLEVFLPPLSCHKEVNVLYTKDWNGLNNGVFFLRVSPWAMEFLSSILAYRTFRPDEELDFTEQSAMARVLELDQYGHHAVECPPQWFNAYPNDGGDPMVHYDHLPGQLLVHFAGIGDKTEAIGEWVGKLEANRSHWEMLVGSTNYEQQIMEFWDGLDEEHAIQQRLKQEKERKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCL3</accession>
    <name>F9XCL3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_109529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852596.1">
        <property type="nucleotide sequence ID" value="XM_003852548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCL3"/>
    <dbReference type="GeneID" id="13396918"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109529"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014245_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCL3"/>
    <dbReference type="OMA" id="FYWLAKY"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="933"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121103" checksum="181911295344AB89" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCR0</accession>
    <name>F9XCR0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_104744</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851944.1">
        <property type="nucleotide sequence ID" value="XM_003851896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCR0"/>
    <dbReference type="GeneID" id="13401281"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104744"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCR0"/>
    <dbReference type="OMA" id="LFWEVPK"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="43"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="440" mass="47456" checksum="64029F99E1D54432" modified="2011-10-19" version="1">MSEKERQSGEQVDREDAPVLPTVNPSAEKSSEPSSSSGGLHPAVYIATWISLSSSVIIFNKWILDTAGFRFPIVLTTWHLAFATLMTQLLARFTTVLDSRKKVPMTGKIYLRAIVPIGLMFSLSLICGNLTYLYLSVSFIQMLKATTPVAVLIASWVFGVAPVNLKTLGNVSFIVIGVMIASYGEINFVLIGFLFQIGGIVFEATRLVMVQRLLSSAEFKMDPLVSLYYFAPACAIMNGIVSLLVEIPKMTLADVEKVGYFTFLVNAMIAFLLNVSVVFLIGKTSSLVMTLSGVLKDILLVLASMLIFRDPVAPLQFFGYSIALGGLVYYKLGGEKLREHMGGLQRSWAEYGVQHPAARKIIVFIGVMVTLGLLLGGVSSSGALGDAYSAGAIASHAGEKLGSWTGKGGAVGEQGGFEENDGLDAIVIIAKRERLLSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV0</accession>
    <name>F9XCV0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851928.1">
        <property type="nucleotide sequence ID" value="XM_003851880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCV0"/>
    <dbReference type="GeneID" id="13401381"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93735"/>
    <dbReference type="HOGENOM" id="CLU_369277_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCV0"/>
    <dbReference type="OrthoDB" id="3641195at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="754" mass="83924" checksum="CCF43CE24BD77AD9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV6</accession>
    <name>F9XCV6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851401.1">
        <property type="nucleotide sequence ID" value="XM_003851353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCV6"/>
    <dbReference type="GeneID" id="13393702"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93740"/>
    <dbReference type="eggNOG" id="ENOG502SR53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023806_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCV6"/>
    <dbReference type="OMA" id="FWATREY"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="30938" checksum="078A85A2951C8683" modified="2011-10-19" version="1">MRMAYDDATDISERRDDEEQPFLHHHKGSPYPTEPFLGMKQGRDCWWSVSGLRSGILRLSDMLASPLLTHGLVFVMAFLFSLAATYFVMFKATAPCSTDLASGHTHHNAERPPSIRPQWPTPPMHGNFSLKAKLTTCGHSTPEAKELGCRYDILSNHWIPGACMDEEAVVEYQADNSWYGFADPAHTKLLTIEEMSEQDFYYTNERDHIVHCAMLWRKQFRAFYEERPNIDALIANVEHTCTVLNFSSICQKEGQTIGACQSRRSWDTRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDR6</accession>
    <name>F9XDR6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851564.1">
        <property type="nucleotide sequence ID" value="XM_003851516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDR6"/>
    <dbReference type="GeneID" id="13401699"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94011"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.495"/>
    <dbReference type="HOGENOM" id="CLU_1278410_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDR6"/>
    <dbReference type="OrthoDB" id="4820608at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395614" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="22783" checksum="CBC2BBB411F49ACA" modified="2011-10-19" version="1">MYSAVTALGLLSLLLRLAAGSPTSPAAHTTKLVTFEDAPVSTNPLSVLLPEVNPVGNYNGLSWSGFVFAGGQGPIVTGVIPHSGSHFAGYGLGSGAQGLFGAAVLTPLPPYKTFSMTSLYFGCVANTVVAVPGAVVGIPAPCQVAFIAYLPGDATPRYEVPESFGVMNSPTMKMTQAKFTGEQLAGVERVEIVVYDNGLPDGSVVAALSALLVDDVAYTLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDU4</accession>
    <name>F9XDU4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_109954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851764.1">
        <property type="nucleotide sequence ID" value="XM_003851716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDU4"/>
    <dbReference type="FunCoup" id="F9XDU4">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDU4"/>
    <dbReference type="GeneID" id="13401713"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109954"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.526"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="F9XDU4"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="276"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP86740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="577" mass="65952" checksum="A5B770DECB8C960B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDZ1</accession>
    <name>F9XDZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein mis14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851604.1">
        <property type="nucleotide sequence ID" value="XM_003851556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDZ1"/>
    <dbReference type="STRING" id="336722.F9XDZ1"/>
    <dbReference type="GeneID" id="13401739"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94074"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.573"/>
    <dbReference type="eggNOG" id="ENOG502SA1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070604_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDZ1"/>
    <dbReference type="OMA" id="EVQRNWE"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25461" checksum="D821B49BAEDA4020" modified="2011-10-19" version="1">MANIFESTAPQPGQRATESTHRKIELQSPADLTYLIANVSAAAREKLNKHFPPDAVQGEDELRGKVEELVDEYIRNTFNGAKDSIFINGMDRAELEAELAKAQEGEELEPFDTRLAQRIQTLSTQVEHQTLALANLRRKAPQDTAAKFTASYEKQVEEYEGKWKLEQERRLQEAKAVTVDVGSVERVEEVAGTWRKGNEGLEELKRGLGGSVAGLEKATRAVGVVGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEE9</accession>
    <name>F9XEE9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_11027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851969.1">
        <property type="nucleotide sequence ID" value="XM_003851921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEE9"/>
    <dbReference type="STRING" id="336722.F9XEE9"/>
    <dbReference type="GeneID" id="13401263"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_11027"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="InParanoid" id="F9XEE9"/>
    <dbReference type="OMA" id="FMMGTAE"/>
    <dbReference type="OrthoDB" id="3641063at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="563"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="632" mass="69628" checksum="F62E74A67B4458A4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XET4</accession>
    <name>F9XET4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850846.1">
        <property type="nucleotide sequence ID" value="XM_003850798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XET4"/>
    <dbReference type="GeneID" id="13397584"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94718"/>
    <dbReference type="HOGENOM" id="CLU_436943_0_0_1"/>
    <dbReference type="InParanoid" id="F9XET4"/>
    <dbReference type="OrthoDB" id="10416563at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="626" mass="71791" checksum="836071B60D261EA2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEW4</accession>
    <name>F9XEW4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850867.1">
        <property type="nucleotide sequence ID" value="XM_003850819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEW4"/>
    <dbReference type="GeneID" id="13397728"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94747"/>
    <dbReference type="HOGENOM" id="CLU_1020162_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEW4"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30653" checksum="4EC488BCC382E705" modified="2011-10-19" version="1">MNRDEGDNNDNKSDTNLHHAPSKVTTSPTAPLVEGNTTTKPASGNKTTRKTPSKKKKTAQPHPRARTPHCDNFLSIPEMRELILLELDEHSILTCMRISRSFEATVRSSIKLQRRLFLAPDNSISPLFINPMVFHATRPTDLMSLALLKSDPNKHFHLKRKIEVNIERGNSRLGSAAEMFVTQPPVNKIRVEVSYWDTNFLEPMLSGGSSGTLELPDGEGIKMKDLVVFAKSKLAEGAEFLRRKPIFGVMGPWTGPEFRLRVETKDGQLVMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF60</accession>
    <name>F9XF60_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850893.1">
        <property type="nucleotide sequence ID" value="XM_003850845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF60"/>
    <dbReference type="GeneID" id="13397712"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94787"/>
    <dbReference type="HOGENOM" id="CLU_722004_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF60"/>
    <dbReference type="OrthoDB" id="10400438at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="383" mass="42426" checksum="6888F060FEA9234D" modified="2011-10-19" version="1">MRLSSPATLVRLNPILITSVTAGTSICRTFTSAIDTNGLPHFTCRFPISSSGMSIPVRHSSHSLTDADTVFEAWRGATFSTTIDDLNDREAYRSMKRAISGDLGKMLITSPSMPTLVIVTFNIRLEHDLDMHIHRFQRIKGAVRMGAGSTVEDLFRAAWMVAREGQRVIWDSVEDMDNTEVRTWDGEELGGVHSSWKRRMLGISMFQTKQSEFWEAGNEEEPEQVGGVLLDDKETGRMGLRCGLEAEEQKLSKVKCLQKPLYHCSSLPVASLKILSGTAGVHPKLITGQLMLRLALHYDNTTLSTRINALYASQGQNTRGVDAYCMFDKTDRLNIVDPAQKQLNGSESQLLYVNHHLATVVNSATTIDLTILPSCFPSTSSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFM8</accession>
    <name>F9XFM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Manganese lipoxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_12169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850677.1">
        <property type="nucleotide sequence ID" value="XM_003850629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFM8"/>
    <dbReference type="STRING" id="336722.F9XFM8"/>
    <dbReference type="GeneID" id="13397918"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_12169"/>
    <dbReference type="eggNOG" id="ENOG502QQSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004282_4_0_1"/>
    <dbReference type="InParanoid" id="F9XFM8"/>
    <dbReference type="OMA" id="MMFNAND"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="558" mass="61477" checksum="6E6966A681D8212F" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFT7</accession>
    <name>F9XFT7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850709.1">
        <property type="nucleotide sequence ID" value="XM_003850661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFT7"/>
    <dbReference type="STRING" id="336722.F9XFT7"/>
    <dbReference type="GeneID" id="13397447"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105207"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_1_1"/>
    <dbReference type="InParanoid" id="F9XFT7"/>
    <dbReference type="OMA" id="PTKFCVG"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="164" mass="17804" checksum="9E6B56B93959D2AD" modified="2011-10-19" version="1">MEYAVEQARHSPPGPDKFCVGAVLVNGDTGEILSTGFSMELPGDIEGDLGTTHAEQCCFIKVAQQHDLPIAMPETHIGPVLPSHTVLYTTMEPCNARLSGKRTCCDRIVALKAQLRTVYVGMREPSTFIVDNDGKQRLESEGIGFEMVEGCYDMCREAAMAGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGG8</accession>
    <name>F9XGG8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_73649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850583.1">
        <property type="nucleotide sequence ID" value="XM_003850535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGG8"/>
    <dbReference type="FunCoup" id="F9XGG8">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGG8"/>
    <dbReference type="GeneID" id="13395295"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73649"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.54"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="InParanoid" id="F9XGG8"/>
    <dbReference type="OMA" id="IISWANL"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="65421" checksum="82C485722871E19C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHD4</accession>
    <name>F9XHD4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-extracellular domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850212.1">
        <property type="nucleotide sequence ID" value="XM_003850164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHD4"/>
    <dbReference type="FunCoup" id="F9XHD4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHD4"/>
    <dbReference type="GeneID" id="13394565"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110632"/>
    <dbReference type="eggNOG" id="ENOG502RVGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022749_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHD4"/>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="599" mass="63599" checksum="EF9911C0ECC13B3A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIA1</accession>
    <name>F9XIA1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_46949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850320.1">
        <property type="nucleotide sequence ID" value="XM_003850272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIA1"/>
    <dbReference type="STRING" id="336722.F9XIA1"/>
    <dbReference type="GeneID" id="13394748"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46949"/>
    <dbReference type="eggNOG" id="ENOG502RZJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009919_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIA1"/>
    <dbReference type="OMA" id="TIDFNRF"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="67"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="529" mass="59714" checksum="BB80823FB95B2DC2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIG7</accession>
    <name>F9XIG7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_74498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849934.1">
        <property type="nucleotide sequence ID" value="XM_003849886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIG7"/>
    <dbReference type="GeneID" id="13402728"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74498"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.154"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XIG7"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="468" mass="50727" checksum="2ACE7EEF8B38B9E2" modified="2011-10-19" version="1">MSSQKSAIDLISQPLTLPCGLNLPNRLVKCPMQETLASPPNFDPPIDKFQNLYKTWSEAKYGLLITGQVQVDLRFLSIAGDVCVHPGSAEPEVMEKWKAWAKIAQKNGTPCIVQLAHPGRMSPAGAGNRPSDMPALCPSAVPVKLGDSWLDKFAVGKVLGTPKAMSVEEIDDAVENFVRGAVVARDAGFAGCQLHGAHGFLLSQFLSPHTNRRTDDHGGTPEKRMTLLKRLVREVRARCPPPYCLSVKLNSGDYMGASGLQQDEALEQVRWLVTCGMVDFVEISGGNAEHTSCKLRSSFGKKTMSEAPKMKESTRIREGFFTDFAEKVQGLESPVPIQLSGGFRSRNGMADALDSGVCDLIGLGRPAVLEPELPKKTLLNPEVGDDHALGIPFQLRGLWFAKMIPAKVVGGGLPIQFFYYNMRRLGQGLTTDTNVSLPWVFIARLWGWAAGSCAAALNRVGLVGGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ29</accession>
    <name>F9XJ29_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 125 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_47544</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849301.1">
        <property type="nucleotide sequence ID" value="XM_003849253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ29"/>
    <dbReference type="GeneID" id="13398922"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47544"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="InParanoid" id="F9XJ29"/>
    <dbReference type="OMA" id="WFAWCNS"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391696" description="Glycoside hydrolase family 125 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60868" checksum="7EDC0B48D902C193" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ96</accession>
    <name>F9XJ96_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849437.1">
        <property type="nucleotide sequence ID" value="XM_003849389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ96"/>
    <dbReference type="STRING" id="336722.F9XJ96"/>
    <dbReference type="GeneID" id="13402463"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95797"/>
    <dbReference type="HOGENOM" id="CLU_738123_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ96"/>
    <dbReference type="OMA" id="HEAVHSH"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390679" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="375" mass="38025" checksum="2B1B32A02E498991" modified="2011-10-19" version="1">MHSTTTLFALVAPLLANAQQAYGPQYQQPSSSAVPPPPPVISTLLPPPPYPHHSYPPYPAGNSSMPASSGTAPGPTAPASTTVPAIPSSSSEAHPYPPQSTSAPPGPPNPYWHGPSSTPGGPNPYWHGPSSTPGGPNPYWHGPSSSSAQPYVPESTSAPPGPPPYPHPPASTSAPPGPPPYPNPPASSSAPPGPPPYPHPPASTSAPPGPPPYPHPPYPAGNSSLPASSGTAPGPTAPATTDRIPYTVPTAGIYTLPPPITLLTSTISAPPACPTTLTYTNPGVLDGCDIKQYGHTSTAWVDCHGCQELVTSTYYNPFAGLGPSQRLQCCAARPDDDECGWGGTATGVLSSAAADEGLEWLREMYEEGRGGGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJL0</accession>
    <name>F9XJL0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_75755</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849472.1">
        <property type="nucleotide sequence ID" value="XM_003849424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJL0"/>
    <dbReference type="FunCoup" id="F9XJL0">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJL0"/>
    <dbReference type="GeneID" id="13402438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75755"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.448"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
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    <dbReference type="OMA" id="ATCDVNC"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:tryptophan binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:chorismate metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="148"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="267" mass="30969" checksum="B23B7AAFD4037996" modified="2011-10-19" version="1">MDSAIDLSNPEKALSLEHIRFQLIRLEDTVIYNLIERAQFTLYTTIYTPGAIPLPGSELSFSDWVLREQERVQSRIRRYQSPDEYPFFEDALEEPILPPIEYPKILWKNDVNLNSELKKRYVESILPGVCHQPVREERTREAQENYGSAATADVTALQSLSRRIHFGKFVAESKFREKPEVFVKLIKAADRKGIDEAITNAAVEKKVLERLRQKAEMYGTDPNMDAEKPRKINVDGVVAMYRDHVIPLTKVVEVEYLMQRLKGTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK13</accession>
    <name>F9XK13_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_62649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849499.1">
        <property type="nucleotide sequence ID" value="XM_003849451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK13"/>
    <dbReference type="FunCoup" id="F9XK13">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK13"/>
    <dbReference type="GeneID" id="13402294"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62649"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056971_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK13"/>
    <dbReference type="OMA" id="EEFVQWS"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="142"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="331" mass="37002" checksum="95A1EDD0FEE24C56" modified="2011-10-19" version="1" fragment="single">MLLQSSRFLSRSAATKTCRAATHHLRCCYNSNQPSSSASRTRPPLDPASPATTSICTKVMPAGDESAATAGDGFTSNNVTPVKDEIEPTQSLAEQCERVHKRVYEFLERKPVSSRVEQVQRQTRESLAVVEEALQKFSQDELSFSYNGGKDCLVLLVIYLAALHTHSKRTGATLPQTLRSVYIVSPNPFPAVTHFVEHTSKKYHLSLTSHHQPMREAFAAYLADNPAIRAIFVGTRRTDPHGAQLTHFDPTDGGWPSFVRIHPVIDWHYTDIWGFIRELGVEYCELYDMGYTSLGGTDDTHPNPALKIEGQEGKFRPAFELVEDLEERLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKK9</accession>
    <name>F9XKK9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_87660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83725.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKK9"/>
    <dbReference type="GeneID" id="13398788"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87660"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.27"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055868_0_1_1"/>
    <dbReference type="InParanoid" id="F9XKK9"/>
    <dbReference type="OMA" id="WLDLWSK"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="35347" checksum="E4FFFFFBE9C02303" modified="2011-10-19" version="1">MPKRSRSPDDDGEDVSAGEAPTTINPYEVLSVDTTATDDEIRKAYRRAALKHHPDKAAPEDKDTAHTKFQEIAFAFAILSDARRRKRYDTTGSTEESLDLEDDDFNWADFFREQYSNLVTTERINDFATQYKGSEEERKDVLKAYEKCKGNMPKLYNEVMLSDVLEDEDRFRLIIDNAIEDGEVEAHAKYTEESEKSRKGRIAHAQKGRDKERGEVAEVEKAIKEKQTKRNVGKKAKGGDEGGMGDLAAMIQQRQTGRAGNFFDHLEEKYAGKGGKGKKGTKMEEPPEEAFKRNAKKTETVEGASKHKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLA1</accession>
    <name>F9XLA1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848793.1">
        <property type="nucleotide sequence ID" value="XM_003848745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLA1"/>
    <dbReference type="GeneID" id="13398746"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96095"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.122"/>
    <dbReference type="HOGENOM" id="CLU_468689_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLA1"/>
    <dbReference type="OMA" id="NIFFEDP"/>
    <dbReference type="OrthoDB" id="10576612at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="582" mass="66651" checksum="83E9714BE00D1B1D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLN6</accession>
    <name>F9XLN6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="6">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MYCGRDRAFT_111003</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="6"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849160.1">
        <property type="nucleotide sequence ID" value="XM_003849112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLN6"/>
    <dbReference type="STRING" id="336722.F9XLN6"/>
    <dbReference type="GeneID" id="13398005"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111003"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="InParanoid" id="F9XLN6"/>
    <dbReference type="OMA" id="KAMMPDY"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:molybdenum ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:molybdopterin cofactor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="525"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="627"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGP84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="845" mass="94796" checksum="C3EBA0C3AF46CD19" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM32</accession>
    <name>F9XM32_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_49969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848439.1">
        <property type="nucleotide sequence ID" value="XM_003848391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM32"/>
    <dbReference type="STRING" id="336722.F9XM32"/>
    <dbReference type="GeneID" id="13396438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49969"/>
    <dbReference type="eggNOG" id="ENOG502SN3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006526_1_0_1"/>
    <dbReference type="InParanoid" id="F9XM32"/>
    <dbReference type="OMA" id="PWLWEIW"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49939" checksum="38AD49AF560D8225" modified="2011-10-19" version="1">MHCTICGVSFRIGRIRTRHEPRSYAWCYYGGDICNQLALPDIDCSSSLGCTFVDRNKSTDDFHSLDSDPEILFPPDGQLPDEAEHSKPAAEDDDITNEAVRPPAWSPAPDDEPWEASSKWMLTGMTTKTEEREVPDEGDWLPFRHGVTEFLADDYHFDNGYDFRTAMPFHPWCLEVYLRAALAQKGRVDVDGLGEWWEQSDRLGGPDEVERCMALETCQGQWWDHEKEFAFLIMDPLKDEGLMGILNEAREVEHGFDPSQSAFLERNSPPPTTDEQHDPFLTLPPELLQHILTLLPTPSIGAARTASRAFTHIPISFFHHLLRKDFPWIWEVDLDTSVALPRYSKWTQKVVDDAREPERDNFDPPDDEAGNEGYNIPPVLPRFQTNWFKLYAALKKAGHSIPGLRNRERIWRDCGQILKKIDEMRVKDEEAAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMK5</accession>
    <name>F9XMK5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_76665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848290.1">
        <property type="nucleotide sequence ID" value="XM_003848242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMK5"/>
    <dbReference type="GeneID" id="13396106"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76665"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.75"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="InParanoid" id="F9XMK5"/>
    <dbReference type="OMA" id="TGVQCVQ"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64143" checksum="C10C26932F75320E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMQ5</accession>
    <name>F9XMQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848312.1">
        <property type="nucleotide sequence ID" value="XM_003848264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMQ5"/>
    <dbReference type="STRING" id="336722.F9XMQ5"/>
    <dbReference type="GeneID" id="13396316"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106091"/>
    <dbReference type="eggNOG" id="ENOG502RZZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="InParanoid" id="F9XMQ5"/>
    <dbReference type="OMA" id="CNPRTHS"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="118"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="47312" checksum="A948070EE9C2446D" modified="2011-10-19" version="1">MTKGLVLARLFHLSGHRVIGADFEPNGALVPGRVSVAISKFYRLQKPKPTPNGSAPYIQGLLDVITKEKVDLWVSCSGVASAVEDGEAKEIVESRTSCKAIQFDVRTTQTLHEKNSFIEYTESIGLTVPETHSITSRDAVAAIFDKAPVGRKYILKPIGMDDSARADMTLLPKSSEKETSAHISRLRISEKNPWIVQQFVRGEEFCTHALIIKGKVKAFVACPSAELLMHYVALPTNSALSQAMQLFTEKFAASWESDFTGHCSFDFLVEDATPNDPKNIVLYPIECNPRAHTAVALFNHTPELADRYLEALSSSSSSTTKSDHITYPTSPRTYYWAAHDLVTLALLPALSLLRGQSSLQDLTQNLASLATQLLTWKDGTYELWDPLPWFFLYHVYWPMTFWKCLVGGKKWSRVNVSTLKMFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMV4</accession>
    <name>F9XMV4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran-interacting Mog1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_49805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848651.1">
        <property type="nucleotide sequence ID" value="XM_003848603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMV4"/>
    <dbReference type="FunCoup" id="F9XMV4">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMV4"/>
    <dbReference type="GeneID" id="13396385"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49805"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.174"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="InParanoid" id="F9XMV4"/>
    <dbReference type="OMA" id="ECSSAWM"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
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        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mog1"/>
    </dbReference>
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        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mog1"/>
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    </dbReference>
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        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21533" checksum="9B73FE4E273DE4F4" modified="2011-10-19" version="1">MTTLQFKTASLFGGAISVDIPQTWADVSEIREVPDTQEVYLDRDGFSSIVVDILERVDKPTDGEALEYHLSDIIDEDLGEAKIRERKDASLRLMPSTPVFTLIATTPPGARQRGRPNEPDFVGVIMILIRLKEQKTDIVVTVNVPHLPNSYDENEMTPEEGKLGPLMESASKVKERVLDTFEVKDFGLFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN64</accession>
    <name>F9XN64_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein bsd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_49968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848592.1">
        <property type="nucleotide sequence ID" value="XM_003848544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN64"/>
    <dbReference type="FunCoup" id="F9XN64">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN64"/>
    <dbReference type="GeneID" id="13396156"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49968"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.299"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041193_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN64"/>
    <dbReference type="OMA" id="SFVWNGM"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="37793" checksum="8D658DF1C9FC1332" modified="2011-10-19" version="1">MSSQRYERLAGQDNDNDGLTQSPVAIPASPPPSFRSHQSSRRHSRDEDSRPNEEERDLDNAFDAPSDDEDDDDDTRDRRLLIATSGSTHSHEGAQSGSTSRPDALPRSVTQLPSFPVPPPGGSGRVVGSSQANDGVFANISAKPRAGEDLEEKPPTYEEASADATPPYWETHILSPYAMSGNPDDVFVDGLLVGSFFSFIWNLLISMSFQIIGFLLTYLLHTTHAAKHGSRAGLGITLVQYGFQTRYGPSNLANSGPGTADPGAPADGIPDDPNSHNFDPSELAGDGPSHSGLDTTQWLSYVLMIVGWFILIRAASDFMKARRQEALIRSSPDRGLGTAVVAENETPETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN69</accession>
    <name>F9XN69_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848590.1">
        <property type="nucleotide sequence ID" value="XM_003848542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN69"/>
    <dbReference type="GeneID" id="13396410"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96691"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.305"/>
    <dbReference type="HOGENOM" id="CLU_1866719_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN69"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15789" checksum="E254ED5211D5E851" modified="2011-10-19" version="1">MPREHWERKVFQDHHETSRILRNTKSWLVDGEQGRETARIGLIKKLSSKAKPNVKPGVQRWNNTFGNRVGRGGVQRTTDAAHCESLRGAPSGVLPIPERGKRRRKQLSDHTRRGKRGAFMSSNRPERRYRGLTGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN84</accession>
    <name>F9XN84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848583.1">
        <property type="nucleotide sequence ID" value="XM_003848535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN84"/>
    <dbReference type="GeneID" id="13396264"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96704"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.321"/>
    <dbReference type="eggNOG" id="ENOG502RX65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872109_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN84"/>
    <dbReference type="OMA" id="GYVNIWH"/>
    <dbReference type="OrthoDB" id="10487474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391584" evidence="2">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="319" mass="30758" checksum="B868F779B0B1BA4E" modified="2011-10-19" version="1">MQFTNLITAAAIGLTTFASAAVQGREPENALVIVQHLAGVSTSTVYSTSKVTVWACDSSVTDCPVGSSTNLVSVVTSVVPVSTTICPLTVTSVTTSGTPGTGSAPLSTTTVTSTAYSFDSETSAVQTAPASSGPAASTAPASSGPAASTGITSSGAASSYASTMSGSSGSPVSSSPAPPGVPAQSSGDSTIQSTLHSTITRQSTVTVPGETLSSGLSSVAGSSIANATEASSSASSMPPAPPAYGPPAQVTSVSSNEAGGVTASGTGYMTPSTNGTLATPTLGSPSETFVPFTGGAAAHDIERMMVCLVIAVGSAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP56</accession>
    <name>F9XP56_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_106406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848014.1">
        <property type="nucleotide sequence ID" value="XM_003847966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP56"/>
    <dbReference type="STRING" id="336722.F9XP56"/>
    <dbReference type="GeneID" id="13402123"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106406"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.371"/>
    <dbReference type="eggNOG" id="ENOG502RFXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091089_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP56"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="24245" checksum="DA22508540ACA1E2" modified="2011-10-19" version="1">MAHNGYPPQGLPMSHRGTYYPTTPPRHPMYTYNHFAGQDLTPSYEYEAITFGQPAVQLSTRALSESFVFQANGSPQSASFEDPPPRLETPRSQHAGSHKTPAVPISPSLATPRVKAKRTPTACEECRKKKQKCDGEQPCQACKEQNIDCQYREVPPTKKDHSLEKLAELMENFSYQLVSLSRRIDTMGMQLKQNEDRMAMLPTSCWHCGSGLQCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP99</accession>
    <name>F9XP99_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_82924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848037.1">
        <property type="nucleotide sequence ID" value="XM_003847989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP99"/>
    <dbReference type="FunCoup" id="F9XP99">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP99"/>
    <dbReference type="GeneID" id="13396043"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82924"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.426"/>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165034_2_1_1"/>
    <dbReference type="InParanoid" id="F9XP99"/>
    <dbReference type="OMA" id="NTMSGTE"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6647" checksum="4FA5CF779C75EA42" modified="2011-10-19" version="1">MARGNQRDKAREKNLAKQAGEKSKNSLSGSEMMRNKDDVAAIMRAKQQAAEAKKAAEAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPZ5</accession>
    <name>F9XPZ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_97361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="13401366"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97361"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:peptide metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurolysin, domain 3"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
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        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391842" description="Peptidase M3A/M3B catalytic domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="285"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="708" mass="78595" checksum="F9DCF58A20622655" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847533.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97369"/>
    <dbReference type="eggNOG" id="ENOG502TBYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9XQ04"/>
    <dbReference type="OMA" id="HQNHEND"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="260"/>
        </location>
    </feature>
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            <end position="486"/>
        </location>
    </feature>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="234"/>
        </location>
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        </location>
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            <end position="362"/>
        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="486" mass="54047" checksum="54B9BBA814352483" modified="2011-10-19" version="1">MAHNEDTPPHIVPATDNQAAAPYVPYQDAMYYNANPRQRRSNHQYRDSRDNDLRDDSYRNSRRNSREDNDFPNENLYRRSYKNANGRNRVVEEHTHRRRRYRPSSPNGNGNGVNLDSPLRSDEADVDAANGIQEDHRPSPKDFFGISDMAQVRRGGVGGVGEDEPELDEYGRRTLHAAALANARRGMGMGGPGGEYYSGAEYADARRRGQHDSQRDSQRSSQRERDRSRRRGGDGARGVRTKRDWEREAEEAEQHRPKESYTLMKAAKSALMAGGAEAFRCRQEPGSWSGQKGKRVALAATTGVLIGTLRNGRLLNSGKMPYAEAAMTGFYSIDFLKRVIRHTEFDKNSKNEKRDWREEARGEAPWQVADEEDENEEGEQDGGNEKGGKDGKDGKGQDGKMTAAQMTAVATMTDDPMTVEGGEITGEMTGETTGETTEGMTEGMTGEPIEDPTKGEKTTGETDDPTAAPPTPDRGRMCESTRNLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQU3</accession>
    <name>F9XQU3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_30708</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847448.1">
        <property type="nucleotide sequence ID" value="XM_003847400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQU3"/>
    <dbReference type="STRING" id="336722.F9XQU3"/>
    <dbReference type="GeneID" id="13400577"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30708"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032274_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQU3"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13419" checksum="8D2F5AD3347DF8AB" modified="2011-10-19" version="1" fragment="single">AQFLGQTADACAYLHQQGIMHRDLEPANSHHSILGAPGSAQFQVYIGQAKRAASSENHMVGTITYLAPETMLLKDRPRPTKVDIWALGLCCWQVLVGRTLTDNDQAMQVAREVVEEFGQNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR68</accession>
    <name>F9XR68_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847230.1">
        <property type="nucleotide sequence ID" value="XM_003847182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR68"/>
    <dbReference type="STRING" id="336722.F9XR68"/>
    <dbReference type="GeneID" id="13399882"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97728"/>
    <dbReference type="HOGENOM" id="CLU_555752_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR68"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="491" mass="54602" checksum="AF8B24F2B6CB4270" modified="2011-10-19" version="1">MAFITEISVTELSGSTRDPGVTSFSIDVPNRTISSYSHILLDVSFPTGVFVQPILDFAIKSIDGLGLLSKRSVAKFRSQIIRPFLPPEDHPLLPLLLRTSNTGDLVQPSLDFAIKAIDGADLLQHNTAARPVLFGTTFMTTMESFSAYDSALHTISQQRRPTPMPRSSTSPPCQAGARTQMASGWHKDFSACKGWRRGVPHCKCVVHISHRSSGAQENGCEYDEQDLDERVALRETWARAMSLPHQDRGHNTPALTTIFAQRITDPHHTAEGNPPCASAHYTLIRNVARSHRIRASTRNRQRDEACQTTILVGRSTEHILGCKTAERIHFWGQNHDTQHLLHRKQVTPRPAPTTPSLFVLSFLAALPLSCFIYFKREHEGWRSGRARRWFDQQGFLNANWQNKSSKHTPSAEKPASARTYTTSSFEASTSSSSMSMHHPAAATQSLSCRSVESTTAHRTVLQLPGLHAPDLLKLTKPTISGKRQHFINGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR85</accession>
    <name>F9XR85_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847279.1">
        <property type="nucleotide sequence ID" value="XM_003847231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR85"/>
    <dbReference type="GeneID" id="13399891"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97744"/>
    <dbReference type="HOGENOM" id="CLU_980727_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR85"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="31637" checksum="260359E4C46BB78E" modified="2011-10-19" version="1">MPAKLYPVAESAQHDQQQMAQKEMKLTSWFDTRLRSRMSKKKSVESRKKMKRRRETCTDAESDSSSDDERDVSKPLLKPSSSHDVDDDSSVMIDVNKNAHSTADLESGDRWPFFQVVPFASSHLFDLVRPNFTVLDRAIRDAARTNAGLPLTDEYDPNDDVVMTSDEEAEDNTTGDHDDGSYVLKTSPVIDPKSGGTQIPHMDQTLLMSRSLPPHDESDDLQLAAPRKSNGKESTPAARNSKVKKTLQGKSLLPTALSSEPASHPRSLLETRFDYILDDSDIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRQ5</accession>
    <name>F9XRQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847101.1">
        <property type="nucleotide sequence ID" value="XM_003847053.1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="76"/>
            <end position="98"/>
        </location>
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        </location>
    </feature>
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            <end position="31"/>
        </location>
    </feature>
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            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26516" checksum="F65845A758E81259" modified="2011-10-19" version="1">MAPSVASAQAHTGGRASKTERIKHEHQHELLNRTTRTVKSEPTDRIKTERSDGITRSVKLEILEPQQRSRYTRYKRNPFIAPPPFSGQGKSSDTDELPYSDWKSQMSTYLTYDRLIPDMGRFTSSAEVFTAMDDSWGDHFLRQRKRSEFGALQQDDNEGFSDFCATFDAYLPYLDLKDDRKKEELRDKLNATCAAEIRGKRFNTLNEMRDQLRVFEVEHREKHQHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Mycosphaerellaceae</taxon>
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            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Martins N."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1397338_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRU4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="20784" checksum="CC3F93B1F5653327" modified="2011-10-19" version="1">MVDFVDGDDDEDEVVVVCEFMLRRSSEEVKTIGAASLRAKTSASNHVPRSIMPPHLLVTDYDDARTLEPPAHGDKSFPEHAPRVLIASALSTASSASHRLAATLGQAPADDVPTSSHDRCPVTIAATNACGGGQCRLDVRHPKTSIPDSTLDEARPTTHPAPCKVSICPSTNTWHDLIGPASRDHPSFSTTDSQI</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="205" mass="23445" checksum="9922D90CBB12CCCE" modified="2011-10-19" version="1">MIQERPVTQIVNLHSIVVRIQPTTRNGEHEKEHEKDHDKEHRKEACWTRSMHLDGFRGVHARCGCLCLMILANQTPTSNAPWLAIEDADRRCEEDHITTQFQLEDNCGDNADTPVPNHDQSTSIEAQHIGSIVNKLEDNRGNNTDTAIHEQCFLKDLMLRFMPNAELESLLPHSICTSSKRVCATPAWLQMFVMQYNNGKYGRKS</sequence>
</entry>
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    <protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9WW99"/>
    <dbReference type="GeneID" id="13403140"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32503"/>
    <dbReference type="eggNOG" id="ENOG502S7MC">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011453_1_0_1"/>
    <dbReference type="InParanoid" id="F9WW99"/>
    <dbReference type="OMA" id="TFDNWTK"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="370"/>
            <end position="397"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="484"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="748" mass="76019" checksum="D6DACC8F9B489083" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWD8</accession>
    <name>F9WWD8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856208.1">
        <property type="nucleotide sequence ID" value="XM_003856160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWD8"/>
    <dbReference type="STRING" id="336722.F9WWD8"/>
    <dbReference type="GeneID" id="13394613"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107116"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.814"/>
    <dbReference type="eggNOG" id="ENOG502S9W4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046290_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWD8"/>
    <dbReference type="OMA" id="KYNESYP"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43079" checksum="337D8E5AA1A9F58C" modified="2011-10-19" version="1">MTPLLHFPPGHAGRADTDTTSPSDKDHSSIERRRLYIDTVHVTDKSRDTPILDLPRVNTKSIPPPRPDAVRRCSTDPSPNTALLQSYFNTTTPTPLKSSSPHRNRSPYSRSHLRTRSSGAALVTAPLMTRAHSSPGPFDLANSISSISLAPSSPMRTPARQRSPFRPIEDSNGNPIRPRSPSWREPSTSSGAIQSIQEDSELDITPRQPLAQFSPLPAPFGRSSSLRRRPASPLHSVLNAASTPPTYLHSDQPPSAGTSASGSPTLAPQRYLNETYPSLHSYASSSSFSSHPSTPTSTRSRSPSISSLETIEDAPDLESEATEAERILRLKLAAERAERAENGEEEDGGRRRSSLDVPRGFGFGSRGGSARERKRWSVCGAERRGDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWI8</accession>
    <name>F9WWI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_52885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856230.1">
        <property type="nucleotide sequence ID" value="XM_003856182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWI8"/>
    <dbReference type="FunCoup" id="F9WWI8">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWI8"/>
    <dbReference type="GeneID" id="13394635"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52885"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.864"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWI8"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="481" mass="53666" checksum="2AAB66878B8E26F5" modified="2011-10-19" version="1">MFPIPVPEEYGVSSTNGFLPTELPIESLPDSYYEPWEYVVKNLQGLVLSKRLREIVEKLPVLSTDRLSSEAEWHRAYSVLAFVAHAYIWGGDKPAERVPPSVTVPFKAACKHLELPPVATYAGLVLWNWKPIFDTERADTLANLDTINTFTGSLDEKWFYLISIAVEARGGAIIPLMLNAIDAANRGNRHTVTLCLQSFAERLDELGAMLARMYDNCDPHVFYHRIRPFLAGSKNMADAGLPNGVIFDDGGPINKQRYVQFSGGSNAQSSIIQFFDIVLGVQHRATGVSKDTTANGTPPKPAKPNSNFIYEMRKYMPGPHARFLEQVARVANIREFVQAHRYDRDLSLAFDACLAMLSAFRDTHIQMVSRYIIIKSREAKKNESAKEEKEKSSKKINLAQPAKTFGEDGAKIKKDLKGTGGTSLIPFLRQARDETGEQAVETWTRRMLSKKGGSTTGELVAEIEQGLAGMWKVEDGGLCYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWW1</accession>
    <name>F9WWW1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_107566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857076.1">
        <property type="nucleotide sequence ID" value="XM_003857028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWW1"/>
    <dbReference type="GeneID" id="13398863"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107566"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1606"/>
    <dbReference type="eggNOG" id="KOG1022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051555_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWW1"/>
    <dbReference type="OMA" id="HYQGVPH"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="5">
        <location>
            <begin position="73"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="36598" checksum="9FD1E046A46CED85" modified="2011-10-19" version="1">MARDKRLIIGATLLVLILTFTLIAQLADESQLKPLSQLTRFYGGSGSAHEPIGPSDGLESVLGNITPAEEDGFTLIAPSWKRLDTLPDWIKHYASGDIPSLRRMIIIWPKVQGDAPTSLLDNVTQSNYPIPVIIDQREVNTLNGRFLKIDAIKTNSVLAMDDDMLYDPKDVEFGYQVWREFGQRERMSGFIARATNKDNTAYNIGGLKSYSMILTKSAWFHTDWMHAYWSQDERMTRLRKYVDDHMNCEDILMAFIHAHHTRKSPLYVKPYKMVDTGMKDGISAAGDHLKHRAACVSKFAEEFGQDTLVSSDAVFQRMLDNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ53</accession>
    <name>F9WZ53_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856265.1">
        <property type="nucleotide sequence ID" value="XM_003856217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ53"/>
    <dbReference type="FunCoup" id="F9WZ53">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ53"/>
    <dbReference type="GeneID" id="13402961"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107183"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.926"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027147_2_0_1"/>
    <dbReference type="InParanoid" id="F9WZ53"/>
    <dbReference type="OMA" id="THSRWDK"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32861" checksum="5A0859CF31CD0630" modified="2011-10-19" version="1">MPLILLSGYPSSGKTTRSQQLITYLNQQILNSPEPRIKRLKVVHITDDNLGLSRDVYAAARPEKDARATFSSAIKRVLDQDTIVVADGMNYIKGFRYQLYCEAKAMQTTNCVVHIGAPPDQCRMWNQSREERERYAEEVFENLVFRYEEPNGMSRWDAPLFTVPLEDAEPPCEAIWEAMIGSDGKAKVVRPNAATVLKPAAEQNYLYELDKTTSDVIGLITGWLGDHEGEGGGEVGVPGSEKEINLPVNSPSLPQLQRLRRQFIQLNRQHTLGKSRIRDLFVDYLNDSFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZT6</accession>
    <name>F9WZT6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_102165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857594.1">
        <property type="nucleotide sequence ID" value="XM_003857546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZT6"/>
    <dbReference type="GeneID" id="13394307"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102165"/>
    <dbReference type="HOGENOM" id="CLU_2742000_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZT6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="71" mass="7977" checksum="91D11E9FD82AE1FE" modified="2011-10-19" version="1" fragment="single">MLPSRQISVLCYMANVFEYTYSKVRRWYAKNGSATALRRVRGIVNGCTSEHGACEYAVRCRLNKSLSAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0F3</accession>
    <name>F9X0F3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serum paraoxonase/arylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_66874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856558.1">
        <property type="nucleotide sequence ID" value="XM_003856510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0F3"/>
    <dbReference type="GeneID" id="13395267"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66874"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1503"/>
    <dbReference type="eggNOG" id="ENOG502RYG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033924_3_1_1"/>
    <dbReference type="InParanoid" id="F9X0F3"/>
    <dbReference type="OMA" id="QACEDMW"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF20">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44846" checksum="EBB7CF525EE43312" modified="2011-10-19" version="1">MNLSTKFGIVFAIFAAALYQGFLKTTLFTTVGLGRVVQPISDFPSYQCRRIHDPRLEACEDMWLSEETRQLFLACSSSASRKEWMPNVGRLNASGRSLNDAIIAMDIDKPKGDSFSYQTLKTPGFGGVNGDGRLHLVGFTARDVKSEDGDKHTTEFYLVNAKPSVDSETGALLDNAQVGPNMTIESFVMQKGFTELKHVKTFHDQHITTPNNIAIDHVDGQPAFFFTNDHGTATHGIKHSLAPLIAEGNVGYCSDTTCRVLSSSWKFPNGLLRGRDDRLYVPSAWVGGIKVFKVNVDRSLEQVSYIDIDYPLDNLSQDANGDIWAAGIPKALKIFAAFDDPLHVVSPATIFRIRRGLDGWEVKKVLEDANGEMLPGATTAIHDVKTGRIFVSGVTAPFITVCDPAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0I9</accession>
    <name>F9X0I9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_90001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857024.1">
        <property type="nucleotide sequence ID" value="XM_003856976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0I9"/>
    <dbReference type="GeneID" id="13398061"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90001"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1722"/>
    <dbReference type="eggNOG" id="ENOG502RKR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049782_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0I9"/>
    <dbReference type="OMA" id="IGDGQPQ"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389866" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="286" mass="29404" checksum="D01605D657FF7598" modified="2011-10-19" version="1">MQYFVAPLALAALAAALPQASTSGECSENYPGTFQIQVVNITNPTKRSAFMEKRQSTALMIQLENGVLTDAQGRIGNIVANDQFQFDPAPGQADAKFTSGFSVCSNGSLAIQGDSTFYQCLSGTFYNLYDEAQAEQCSPVHIQVINGSGGSASQLPDGQVTGSPASEMPEITGMAVSQIAEIQGPTGAPVQQISDGQLQATTAAAAPVTQIADGQVQAPTNSPIQQIADGQLQQPTGSPVQQIPDGQLQSNGSATTTAPAQYTGAANIVKTSVFGLAAGVMALAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0N6</accession>
    <name>F9X0N6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Catalase-peroxidase</fullName>
            <shortName evidence="9">CP</shortName>
            <ecNumber evidence="9 10">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">katG</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_67250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9 10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="9 10"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857005.1">
        <property type="nucleotide sequence ID" value="XM_003856957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0N6"/>
    <dbReference type="STRING" id="336722.F9X0N6"/>
    <dbReference type="PeroxiBase" id="9926">
        <property type="entry name" value="MgCP02"/>
    </dbReference>
    <dbReference type="GeneID" id="13398089"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67250"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1780"/>
    <dbReference type="eggNOG" id="ENOG502QTDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0N6"/>
    <dbReference type="OMA" id="WPCELNL"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9 10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006991487" description="Catalase-peroxidase" evidence="9 10">
        <location>
            <begin position="23"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="177"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-143)" evidence="9">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="796" mass="86420" checksum="35802EE36551354D" modified="2011-10-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X100</accession>
    <name>F9X100_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857341.1">
        <property type="nucleotide sequence ID" value="XM_003857293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X100"/>
    <dbReference type="GeneID" id="13394804"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102471"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1032"/>
    <dbReference type="eggNOG" id="ENOG502R41Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="F9X100"/>
    <dbReference type="OMA" id="IFYIHAP"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="34779" checksum="826D7E71A24B66C9" modified="2011-10-19" version="1">MSGIKVVFGAAGVNPPRAFGTTEAVKEVFDVLENGKCENIDTAALYGQSEKILGEAGIAKHSFIVDTKLKGGFEGGATKENVLAQAKNSKELLGTNVDILYIHAPDHNTPLEETLAAVDEVHKSGFFKRFGLSNYKAEDVQKVYEHCKEKGYILPSVYQGNYSAVARKQEEVLFPTLRKLGMSFYAYSPLAGGFLTKTKEQVLEGAGRFNKNEPIGNMYATMYAKPSYLEALAQWAAIAKEEGCSQADLAYRWVRYNSPLKKEQGDAIIIGASRLEQLKETLDSINGGPLSDEAAKKIDEVWKTIEHEAPLDNYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1I3</accession>
    <name>F9X1I3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_32115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1I3"/>
    <dbReference type="GeneID" id="13398254"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32115"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1978"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_2_1"/>
    <dbReference type="InParanoid" id="F9X1I3"/>
    <dbReference type="OMA" id="CFSIVMS"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="502"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="538" mass="58990" checksum="40A7B1FA492F9DA0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1X3</accession>
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        </recommendedName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
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        <property type="protein sequence ID" value="EGP90797.1"/>
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    <dbReference type="OMA" id="MYDMMKY"/>
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    <dbReference type="Proteomes" id="UP000008062">
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_dom"/>
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    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <position position="279"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="279" mass="31854" checksum="21E8FD490FE00A3C" modified="2011-10-19" version="1" fragment="single">MPPPSNIQHLPATHPATRQRPKSPERVLAEAEAQWLFNEEELANTPSIQDGLSLTEERSLRAKGVNFIVQCGIMLKLPQLTLSTAAVFFQRFLMRGSLKRPRGDIPKLHHYTAAATCLFLATKVEESCRKMKEMVLAFCRTAQKNPNLVIDEQSKDFWRWRDSVMNEEDVLLEALCFDLTVESPHRALFEMLKTYGVEHNKRLRNAAWGFVTDSNNTQLCLLCNSRTIAVAALYAACRYVDVSIPDDKAGRPWWERQHVSLKDVRQAVEYMLANYDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1X6</accession>
    <name>F9X1X6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90328</name>
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    <organism evidence="1 2">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855820.1">
        <property type="nucleotide sequence ID" value="XM_003855772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1X6"/>
    <dbReference type="GeneID" id="13395910"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90328"/>
    <dbReference type="HOGENOM" id="CLU_1908333_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1X6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="14015" checksum="58A04471929CC05F" modified="2011-10-19" version="1">MPRAIERGRLAEAVESFAGLPGVPNATVQVFTTPEGPPANVGNRKVSAVGHKAATVTEYALDRLQVLVNCRLSSGSSRTGGSGDIGRCEDVASAIPAQSGSMPHIWRSLRSMLYRGVGIKYIVGSAIHKADVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Z7</accession>
    <name>F9X1Z7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_84372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854708.1">
        <property type="nucleotide sequence ID" value="XM_003854660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Z7"/>
    <dbReference type="FunCoup" id="F9X1Z7">
        <property type="interactions" value="673"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1Z7"/>
    <dbReference type="GeneID" id="13395877"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84372"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.45"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="F9X1Z7"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="50"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="393" mass="42846" checksum="2849F79D6E27F62A" modified="2011-10-19" version="1">MASSWNLLTATPRTLLRSAPKVLPSSRRSISAYGYEQAKCLILPNTGEPKDVLRLHSHSISPPTGNLVTLQLLASPINPADINQIQGVYPTPPTWTTSLGTPDKIAVGGNEGVAKVIAKGGNVKGVQKGDWVIFKKQGFGTWRTHAQTDVSNVTVVKNTDGLKPEQVGTVSVNPCTAWRMLKDFGTVKEGEWFVQNGANSGVGRAAIQLGKLWGMRSINVVRKRETGHEELVKELEGLGADVVVTEEELNGKEFKDRVKELTNGGREPVRLGLNCVGGKLVNSMAKLLAPGSAMVTYGAMSKQPVTLPMGLLIFKDIQFKGFWVSRWSDANPEEKMKCVEEVMDLTKKGRFKDVPMQTVKWDRGTKQEELVDAVQGTLDGYRSGKGIFVFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X203</accession>
    <name>F9X203_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_90353</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854713.1">
        <property type="nucleotide sequence ID" value="XM_003854665.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X203">
        <property type="interactions" value="1184"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X203"/>
    <dbReference type="GeneID" id="13395882"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90353"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.52"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="F9X203"/>
    <dbReference type="OMA" id="IDEYHCY"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
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    </dbReference>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="640"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="825"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1648"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1926"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1531"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89689.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2296" mass="257634" checksum="E306927964869064" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X216</accession>
    <name>F9X216_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminocyclopropane-1-carboxylate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ACCS1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_37004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854718.1">
        <property type="nucleotide sequence ID" value="XM_003854670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X216"/>
    <dbReference type="STRING" id="336722.F9X216"/>
    <dbReference type="GeneID" id="13403741"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37004"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.64"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="F9X216"/>
    <dbReference type="OMA" id="YPAFYRD"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF32">
        <property type="entry name" value="AMINOTRANSFERASE GLII-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="405" mass="44469" checksum="5295EB0F38553D62" modified="2011-10-19" version="1">MKSVINLARAENQVVRKELLAIYKTSIRRELRVDSLTYPDGLGGSRSLRSALAGFFNRWLCPIEPIKDEHIAVTPGATNCLATILSCTCSPGDTVLIPGSYWNGFDVHFPLTPRVVIVNPAPKDSPANDMGPEIVASLEETIRQLSSTKKPRAIVVTNPHNPTGRVYDRTVLEDLAILCQRHSMLLIVDEVYALSRCAPTRTKGTSFRSAVSLDLNALGVDAKRVVTVWGTSKDFGSSGIRIGCAITRDPRLQKNLGFRATPQICALSSLVTTGLLNHSSLPHLIQRNQEFLGKAYRIVDKWCTSHEVDFVPAAYGLFVLARLAPLAQTAEDECAMCEALSEVGVLVAPGQHFHWRSFGWARICFAVEPDTLREALRRIASALKLARTPVSQRARGKNGHKKPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X343</accession>
    <name>F9X343_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_108180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="566" mass="60904" checksum="3B8A6886D016672F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Dothideomycetidae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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        </location>
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            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="642" mass="69440" checksum="D53859DD827E8C43" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4H1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90832"/>
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    <dbReference type="InParanoid" id="F9X4H1"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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            <end position="426"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29270"/>
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    <dbReference type="InParanoid" id="F9X4R9"/>
    <dbReference type="OrthoDB" id="3649644at2759"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="105" mass="11034" checksum="C0F7609F28DFFB6E" modified="2011-10-19" version="1" fragment="single">LQVASRSGCEALVRSLLRLGASPDGLPHEAGFPLGAAARRGYCSIIRVLCDADADVNAKDERRQETALMIACESGQLGAATILLDAGANLRAEIAFRETSLYMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5G2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003853634.1">
        <property type="nucleotide sequence ID" value="XM_003853586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5G2"/>
    <dbReference type="STRING" id="336722.F9X5G2"/>
    <dbReference type="GeneID" id="13400888"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108406"/>
    <dbReference type="HOGENOM" id="CLU_2051506_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5G2"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="120" mass="12982" checksum="5C285A4150496F55" modified="2011-10-19" version="1">MFTTSSAGKKRSRVDDDETTLQSFSSPLEKRSRPTANASGAPSPWLHRYHDSVLSTPTLSRSSTLGIPRSPPKYDSEDDENSSEISEPVAVSLAPAKRPAFPHPSSLCVRNPPPPPVQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6B6</accession>
    <name>F9X6B6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853891.1">
        <property type="nucleotide sequence ID" value="XM_003853843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6B6"/>
    <dbReference type="GeneID" id="13404229"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91804"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.636"/>
    <dbReference type="HOGENOM" id="CLU_1846719_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6B6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="139" mass="15243" checksum="801B134F0EB92446" modified="2011-10-19" version="1">MRCFYERHYSDDDEDSSFDAYGLPREDGETASSSGSEPQSQQRGKIEKLPLPDEICNAIDGICEATWSKWAASGPLTGPFADPQLSIDDSGPIRLPLSETVRTSGSRPDYGPSKQTFPEGMLLISQCRSPYPAMLALLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6S2</accession>
    <name>F9X6S2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_69661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854490.1">
        <property type="nucleotide sequence ID" value="XM_003854442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6S2"/>
    <dbReference type="STRING" id="336722.F9X6S2"/>
    <dbReference type="GeneID" id="13404106"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69661"/>
    <dbReference type="eggNOG" id="ENOG502QS1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="InParanoid" id="F9X6S2"/>
    <dbReference type="OMA" id="SIVCTNP"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31753" checksum="9973D51F73741EE1" modified="2011-10-19" version="1">MATKPNKTLFTLSTPSSYSSTGKATVTCTEPRPKVYLLTFSSPPDNRLASPFCTTLLLAFDILHHRYPPGVIITTSAIEKFYSNGMDIEHSQVTRMYFPDVLYRLWKRVLTYPMPVVALVNGHAFAGGAMLVGMHDYRIMNPHRGYICLNELELGMPMPPAMLGVFKEKLSGATFRKLVLEAHRYKALEALEDGLVDSVGGLDEALAFIEEFQLVKKAQPGASGRSVYGELKREMWRKTVEYLDDAVGESRRLETVREGRKREEERSLKNVESWERARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X773</accession>
    <name>F9X773_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_103683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854470.1">
        <property type="nucleotide sequence ID" value="XM_003854422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X773"/>
    <dbReference type="FunCoup" id="F9X773">
        <property type="interactions" value="1070"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X773"/>
    <dbReference type="GeneID" id="13395656"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103683"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.418"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="InParanoid" id="F9X773"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="125"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="265" mass="29768" checksum="C5F38903EDBF6EEE" modified="2011-10-19" version="1">MPPKAGGKKAAPAPFPASKAGGASKKPAKNPLIERRPRNYGIGQDIQPKRNLSRMVRWPEYVRLQRQRKILNMRLKVPPAIAQFSQTLDRNTAAHTFKFLNKYRPETKVEKKERLHKEATAVSEGKKKEDVSKKPYTVKYGLNHVVALIEAKKPALVLIPNDVDPIELVIYLPALCRKMGVPYAIVKGKARLGTVVHKKTAAALAITEVRAEDKTELSKLVQAVKEGYLEKNEEAKRHWGGGIMGAKAQAHQRKIRERAEREIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7M6</accession>
    <name>F9X7M6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_38090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854569.1">
        <property type="nucleotide sequence ID" value="XM_003854521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7M6"/>
    <dbReference type="STRING" id="336722.F9X7M6"/>
    <dbReference type="GeneID" id="13395756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38090"/>
    <dbReference type="eggNOG" id="ENOG502SIQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_6_2_1"/>
    <dbReference type="InParanoid" id="F9X7M6"/>
    <dbReference type="OMA" id="RIRCELY"/>
    <dbReference type="OrthoDB" id="3647238at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="15376" checksum="E7BA208E41E5549B" modified="2011-10-19" version="1" fragment="single">MDVSRAGQCRCRDLDPQSKEIRLVNVLAGQPSDPMRCSLIYTPLSHATVPFETVSYCWGRSTLEKTIEIDERPVAVTASAAGVLYRMRLPDINRLLWIDAISIRQDSDREKPHQISLMGSIYSRAWRNLIWLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X814</accession>
    <name>F9X814_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_92203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854136.1">
        <property type="nucleotide sequence ID" value="XM_003854088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X814"/>
    <dbReference type="GeneID" id="13404494"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92203"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1124"/>
    <dbReference type="eggNOG" id="ENOG502SVNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900814_0_0_1"/>
    <dbReference type="InParanoid" id="F9X814"/>
    <dbReference type="OrthoDB" id="5143362at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395401" description="Ca2+-modulated nonselective cation channel polycystin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="30680" checksum="3C915007296DF48B" modified="2011-10-19" version="1">MHNRNPQSRRLTSLLNPTLLLTTFTTLTTALSPSALITIESSSGGAGNNLSNTTLSIPLSTLYTNPALDIASALYLSGATGADTSSITCYSYQDSDLTNPGGQPFSQFKPSRLSTNTVQVGSIVCNSTSTSIPDYNANATGVTSTLHATSTQLTRGSVSDVPNLGANVSVPLGPGPVILSSTLSSNTSSTSSTSTSSNNATASSTSTSLPTVTNASGGGGLVGPPRTVVTGVTSITSSESPVGAMVTEMRTEVVVSPTTTTTGSSVEGSSTAVVQGSQGAAAGGKRIGSWATFVVAGGFGLVGVVVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X827</accession>
    <name>F9X827_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854142.1">
        <property type="nucleotide sequence ID" value="XM_003854094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X827"/>
    <dbReference type="GeneID" id="13404481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92216"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1139"/>
    <dbReference type="HOGENOM" id="CLU_1031367_0_0_1"/>
    <dbReference type="InParanoid" id="F9X827"/>
    <dbReference type="OMA" id="RRARTYH"/>
    <dbReference type="OrthoDB" id="10653474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="270" mass="30323" checksum="396CE0E92ADBD90F" modified="2011-10-19" version="1">MANPTAQQPNLLDSIDDVYDMFHRGQNAAFAEAADDLLDNYPKLNRFHRVQLMALLVRVVDDYQEVDQLYDEALREFRTLKRHFLYNGNDNPNFESHLQKLQVILDGSKTVVDEMAGISSEPADGQDAEMEEDGLEMEEESVEMEDENAAMEEEDGDDTLIPDTFPLPTISLSDLPSSSPNLMADDTLPLSESSQQFQNSTDPTEMSEEPKSDDLPIRPAPHKEGKFGGSMRRRYGKGLLKEKMSIADLRKISGVPPPHDEKDEEGMASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8C5</accession>
    <name>F9X8C5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MgBGL9</name>
        <name evidence="19" type="ORF">MYCGRDRAFT_41307</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852917.1">
        <property type="nucleotide sequence ID" value="XM_003852869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8C5"/>
    <dbReference type="STRING" id="336722.F9X8C5"/>
    <dbReference type="GeneID" id="13400465"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41307"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="F9X8C5"/>
    <dbReference type="OMA" id="VEANTMQ"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="18">
        <location>
            <begin position="676"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="761" mass="81919" checksum="C9FF608F8B8CB120" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8J3</accession>
    <name>F9X8J3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_71228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853379.1">
        <property type="nucleotide sequence ID" value="XM_003853331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8J3"/>
    <dbReference type="STRING" id="336722.F9X8J3"/>
    <dbReference type="GeneID" id="13397352"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71228"/>
    <dbReference type="eggNOG" id="ENOG502S0DI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028621_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8J3"/>
    <dbReference type="OMA" id="KVVFRWK"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="432" mass="47596" checksum="571EB64CED318AF1" modified="2011-10-19" version="1">MLDENLPAFFLKPSATKIPHHRDIYLSHHGSEPSPFYVIQNSDPTSQLPAHRNVYAAALFDAYNPSVLFGEVLVRPAWSQPTLNAEEIRRNNGITPPPVPLLPNEFVVQLYNPEQQVRVEVKEGKWGASDSYEFAMPQTSFRTPSASNLDRGQSDPASLAITPKVNFVWRREGKLSKDLTCFMTGKSTDTVAAKKSKHRDPDIAIALWRSMREMTIYESNLGRVLEDMEDPKGLEVALLLGAVVIKDLYFGIKGQSEMKEVFNISELPEERKLSGGGRKVVSPPKAGIAAPPPPPKAAARRKKEREKADEAERKRLLKVVEEEAKQARKKAAEVERETERLRRLYGTQGQANSSQLRIPQQQPVVDPRLRRPASAQGSYGQARPPWSGSASSSALVMSGANGVVMSGGGGPGQRPPAVKPKKSSFFGLMSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8K4</accession>
    <name>F9X8K4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_104294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8K4"/>
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    <dbReference type="FunCoup" id="F9X8K4">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X8K4"/>
    <dbReference type="GeneID" id="13399769"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104294"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.752"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="InParanoid" id="F9X8K4"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="205" mass="22107" checksum="1DCC4EAD48136252" modified="2011-10-19" version="1">MAPKIAIVFWSMYGHVQKLAEAELAGIKAAGGTADLYQLPETLPQEVLTKMHAPPKDANIPVLEDPKTLEQYDAFLFGIPTRYGNFPAQWKTFWDKTGGQWQSGAFWGKYAGLFVGTATAGGGQETTAMNAMSTLTHHGIIYVPLGYKHTFALLSDLSEVRGGSPWGAGTFSAGDGSRQPSAKELELATAQGKAFYEQVSKVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">DUF7071 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853245.1">
        <property type="nucleotide sequence ID" value="XM_003853197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8L5"/>
    <dbReference type="GeneID" id="13399762"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109288"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.763"/>
    <dbReference type="eggNOG" id="ENOG502RG3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432774_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8L5"/>
    <dbReference type="OMA" id="EAMAPAM"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7071" evidence="2">
        <location>
            <begin position="372"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="762" mass="83770" checksum="5917C0459CAA89E4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8Z0</accession>
    <name>F9X8Z0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_70969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852943.1">
        <property type="nucleotide sequence ID" value="XM_003852895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8Z0"/>
    <dbReference type="FunCoup" id="F9X8Z0">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8Z0"/>
    <dbReference type="GeneID" id="13400438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70969"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.323"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8Z0"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="197" mass="21933" checksum="EEACAF2E5ADA38B1" modified="2011-10-19" version="1">MTSKAARLGEEVWKTRVEKISSEVVTLTYGTIVAQLCRDLLLPTSSTQTDYAAVNAELDRMGYNMGLRLIEDFLAKSNTGACANLRDTAEMIAKVGFKIFLNITPTVTGWTQDGKGFGLVFEENPLGDFVELPDDGRAQGELWYSNVLCGVVRGCLEMIQMQVEAKFVSDVLRGDDTTEMRITLLRYIEDEMPPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X943</accession>
    <name>F9X943_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CYTb5</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_71290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853052.1">
        <property type="nucleotide sequence ID" value="XM_003853004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X943"/>
    <dbReference type="STRING" id="336722.F9X943"/>
    <dbReference type="GeneID" id="13400181"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71290"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.550"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X943"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="314" mass="33230" checksum="0983FF7C0EB4B90C" modified="2011-10-19" version="1">MGALSILILIVSISFLTIRYPVMLKGLLPAWFSAAERKDFDSKDESRLSHGSEASDQGRTSTSGDEADGDSTPKAEPTRNEEAVPTFTLSDGTAEEVPESPAEPVTPMFPAANSAQRASSSMPPPPRPTKPSASSLMPPPGRPVPSQKQSAAASLRIPSNGPLPNRGPPAGSQQRVNSSLSPNGAVSTPNSRGKVLLSPGHSPMDWAALVKSGNLAGVSTFQRVTPSELKKMTGRKGKPAWSSWQGKVYNITPYLPFHPGGEPELMKAAGRDGTKLFMDVHPWVNWENMLSTCLVGVLVPEDHGAGSGSLEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9E7</accession>
    <name>F9X9E7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_108999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
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        <cofactor evidence="1">
            <name>FMN</name>
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            <dbReference type="Pfam" id="PF00724"/>
        </source>
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            <dbReference type="EMBL" id="EGP88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="46288" checksum="E169A47F6642761D" modified="2011-10-19" version="1">MSTPAHLVNRPAPNTPYFTPLQDPPAGTALVEDGKKDAVPKLFRPLKIRGLTLQNRIMLSPLCQYSAPDGHYTMWHHTHMGGIIQRGPGLTCVEATAVTPQGRITPEDVGIWQDSQIEPLAKVVEFAHSQNQKIMIQLAHAGRKASTVAPWLSGGDVAGEDVNGWPQDVWAPSAIPWNEKHAVPKEMSLDDIEAFKKAFGEAVKRALKAGFDVIEIHNAHGYLLHEFISPVSNTRTDKYGGSWENRTRLTIEVVDLVRSIIPKDMPLFLRISGTDWLEESDIKESWTSADTAKLAPILAEHGVDLLDVSSGGNHPKQHPHSKPAYQAPFAIEAKKAVGHNMAVSSVGSIDSAKLANDLLEKDGLDLIIVGRAFQKNPGLVFQWADDLDVKVQMPNQIRWGFGGRGASADNVTPATKIPELIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9H6</accession>
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            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">MYCGRDRAFT_40901</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40901"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.345"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Beta-prop_NOL10_N"/>
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        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="411"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <end position="617"/>
        </location>
    </feature>
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            <end position="638"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="750"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="759" mass="83932" checksum="BDA22B2E3461437A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9J1</accession>
    <name>F9X9J1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_57922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853447.1">
        <property type="nucleotide sequence ID" value="XM_003853399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9J1"/>
    <dbReference type="STRING" id="336722.F9X9J1"/>
    <dbReference type="GeneID" id="13400417"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57922"/>
    <dbReference type="eggNOG" id="ENOG502SC6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843480_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9J1"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="309" mass="33979" checksum="6CB41802292DE719" modified="2011-10-19" version="1" fragment="single">MNDEDAPGTGTSTPLDSTQMSQSASKAAPVKDRQCPFCNQSFTSSSLGRHLDLYIRPKNPKPADGVHDVEEIRKLRGGITRRQVKSGTKGGNGSEQRGSRESFSATPTASEPSTGRACITNKAAWQATGVINDLPPRAMENGPPRPPLDAGGNRIQRPEYESESMLKLQEAAELGRAAEMALREVLGNLEAAKKAVKPKNLYDDFDFYSLSFPGLCLAILPPPGTLFTPTPFPSAESWTLEPPGQRQYETMNRFLNLRITERQASDNISDSIAFKHHAHLSGAWEHWQTLVPSERSSAWTLEVLRSYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9K1</accession>
    <name>F9X9K1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor synembryn-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_85675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852965.1">
        <property type="nucleotide sequence ID" value="XM_003852917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9K1"/>
    <dbReference type="GeneID" id="13400411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85675"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9K1"/>
    <dbReference type="OMA" id="NADPIFT"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51283" checksum="1ADC214D7BB3B284" modified="2011-10-19" version="1">MEAPLAPQKWTDCCSNLRRTSKARSSLCNAVLQTTPAQSSQSGQGITVLSKYGLDRDDAPDTSREALRCLANAFYLNEPCRQTFVDLGYAPKAAERLKVDNRDDEFLVARMLFLLTYKTKIDFGALINQHQLAESINQHIARHAKRFSKPERTSSATSPMHDMSMTETLKLLYNIIHHYPDQGSRFLPSIEPLINIILYFPLQEQPLQPPITSALNALGKLDLQATEPGAKVEQESSVSPLFPQSDPKSVIERLTFILDGAIRHQAEKDIDEAAATLCALLILGYELGTQETKSWMQQLLLPTSEDRERPLGQGNTLASRLLRLSCSPVLPRLRIVISSLLFELSDKDPDRFIKNIGYGFASGFLTSKNIQIPRTAMDSGSTESDGVTGTGFDINPVTGQRLSAERANAPKVKEMTDEEKEREAEKLFVLFERLKATGVMNVQNPVEQAIQEGRFEELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9P7</accession>
    <name>F9X9P7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853068.1">
        <property type="nucleotide sequence ID" value="XM_003853020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9P7"/>
    <dbReference type="GeneID" id="13400004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92696"/>
    <dbReference type="eggNOG" id="ENOG502T2CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994678_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9P7"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="280" mass="30994" checksum="4D317E5B01C89925" modified="2011-10-19" version="1">MLSRPTMRSYILKGQATKDLSTAKPRNDTHSKQSSCIPLGHMHGEPSLCRASACTLVGGKNEWPGAYMLGLEPRETNIFGLRAHCQAKHSCSHTAITAMKLMIQTLLGASWFVRALAAPQVTFLTFLVLGFAFVDPDGIYRAYLADGSVVDAARLTPEQLQHWLDVRAPLLSASDAENERTTYATANPQDVPEEQLLHPPDEIKPHAQIESMAEFVISPNPNPLQVTKRQVACPPMYCVYRDLACFQPRTVRECLVVGFVGWALARVSHRVTCWNTVEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAL5</accession>
    <name>F9XAL5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="13393802"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109341"/>
    <dbReference type="eggNOG" id="ENOG502SU9K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531231_0_0_1"/>
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    <dbReference type="OrthoDB" id="3643957at2759"/>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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            <end position="65"/>
        </location>
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        </location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="299" mass="32687" checksum="3AB80DA4F7219A7F" modified="2011-10-19" version="1">MSLASSMALPATGPETRLLCRANKLNIPTCGIAPGYLQVNLIVLPSRFAEDFAIFCARNPVPCPLLARSAKPGDFSNFVSHIPGVSNDQIAYGVDIRTDAARYNVYVDGKLKETSIMDIKSHWDDSDHVAFMIGCSYSFESALSAAGLPPPHCVLSRNVSMYRSILPLCPSGPFTSSTFVVSMRMYRKSEVEKVRDITRPYVATHGEPVAWGWEGMRGLGITDVNDVQWGDPPLTGEGKPPVEFAETKRLDGYVPVFWGCGVTPQEAVCRAKIPGVVMGHAPGYMIVLDVKEEDILHKH</sequence>
</entry>
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                <person name="Hane J.K."/>
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                <person name="Bluhm B."/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </reference>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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            <end position="457"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62615" checksum="583B112506F25E84" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBL1</accession>
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        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852646.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.236"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XBL1"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="363"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
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    </feature>
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        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1125" mass="127590" checksum="76D7FD6518AF4046" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
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        <subcellularLocation>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="32"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="187"/>
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        <location>
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            <end position="322"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EGP87642.1"/>
        </source>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77375" checksum="D69835D4F20A2A37" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC80</accession>
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        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_109489</name>
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    <organism evidence="3 4">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Hane J.K."/>
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    </dbReference>
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        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="178" mass="19583" checksum="1BF6DB13D9472202" modified="2011-10-19" version="1">MTDEHDRFIPSQEHDGQVKTVLPPAPMTTTPSVLASTIENASEGSPEHNRHSSDGGGSVILSVFDSEQRVKGALDDDSEHTRTSSGPRRRLFAAWRLEVLSCIMVVAGLLALVGTLYAYEDRPSPKWPRWKSLNTIVSIYAIIIKAGIVLVLSEGIGQLKWSWFSKLKPLSPRYADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD68</accession>
    <name>F9XD68_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_28928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851870.1">
        <property type="nucleotide sequence ID" value="XM_003851822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD68"/>
    <dbReference type="STRING" id="336722.F9XD68"/>
    <dbReference type="GeneID" id="13401441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28928"/>
    <dbReference type="eggNOG" id="ENOG502S4VQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096872_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD68"/>
    <dbReference type="OMA" id="PRFETGH"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="151" mass="17000" checksum="D7AE2682A34EAC47" modified="2011-10-19" version="1" fragment="single">PLPTLTFLLHLECEMETFRHIGQGPFGDRSTVIFKGGRFEGPRMRGEILPGGGDWEIVRDHEDQQTAYLNTRYNLVTHDGATIYLQTTGTRTGPKEILEKLGDDTSITADQFKMRLHLTFETGDPRYSFLNQMVAIASSGRVGSQVIYDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA2</accession>
    <name>F9XDA2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_100493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851480.1">
        <property type="nucleotide sequence ID" value="XM_003851432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDA2"/>
    <dbReference type="STRING" id="336722.F9XDA2"/>
    <dbReference type="GeneID" id="13401539"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100493"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.315"/>
    <dbReference type="eggNOG" id="ENOG502QRMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDA2"/>
    <dbReference type="OMA" id="ATWNKRE"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45268" checksum="6A1869E6B544B796" modified="2011-10-19" version="1">MGKKAIRHAAKVELDKEAGTLPYLHNRWHPDIPTIGKIENNEVVKIQCVDWTGGQIGNNDSANDMRDVDLTKIHYLTGPFEIETAEPGDILVVEIQDVQPLEEQPWGFTGVFSKKNGGGFLDEIYPEPAKAIWDFEGIHCSSRHIPGVRFAGLIHPGILGCAPSQEVLELWNKREGELISACAHMDRDVAKPPEPINVHAGTADEKIKEKVGREGARTIPGRPEHGGNCDIKNLSRGSKVFLPVHVKGAKFSVGDLHFSQGDGEISFCGAIEMAGEITIKFSVMKAGMEELGTKSPIYIPGPVEPQFGPGRYIYFEGFSVDEHGKQHYLDATIAYRQTCLRVIEYLRRYGYNDYQIYLLLSCAPVQGHIAGIVDIPNACTTLGVPIDIFDFDITPGKKVEKRDMGACAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDB0</accession>
    <name>F9XDB0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851485.1">
        <property type="nucleotide sequence ID" value="XM_003851437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDB0"/>
    <dbReference type="GeneID" id="13401544"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93870"/>
    <dbReference type="eggNOG" id="ENOG502RM6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1344193_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDB0"/>
    <dbReference type="OMA" id="HENPEMG"/>
    <dbReference type="OrthoDB" id="3641029at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="22831" checksum="05B2D5EE440139C2" modified="2011-10-19" version="1">MITPRTDTSPSTPTSTQACHHLSASSLIISRTALIVPLTLLIFTTLASLLALTALLYREHARQKAHKAATQWGRKSRVDARISIMRKRVDEEFTAKYSGCLVNVYENPEMGSDSPVELMMPERVWEVEGGDCRTREVERKGRVRSLFFDHGVGLWMQKLSSNGHKSVQVTTTEKLDRNAVQNSLRTIPDRANPSIRSLAVFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDI1</accession>
    <name>F9XDI1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_93936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851521.1">
        <property type="nucleotide sequence ID" value="XM_003851473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDI1"/>
    <dbReference type="FunCoup" id="F9XDI1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="13401580"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93936"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.401"/>
    <dbReference type="eggNOG" id="ENOG502S1H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087050_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDI1"/>
    <dbReference type="OMA" id="DRMQDVF"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="193" mass="21320" checksum="2C6C3AE614518C2F" modified="2011-10-19" version="1">MSTATPYYQYQQYQPTSSLPVNVPGKNAQQLYVPRHSRNSSGYSQLSASPPERPESVSSTGAGLYSSASSNYGGSEYDSSSGATGVDLLDYMNDRLSQAYNPIPMDKNVARQAQMSGELNAKNRELLGLQAQARSRLAKTRANFAEGMKAAKEVQRDLEYTQKKMHALNARAAEKYPEQYRAASRRYPAPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDT8</accession>
    <name>F9XDT8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_73357</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851768.1">
        <property type="nucleotide sequence ID" value="XM_003851720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDT8"/>
    <dbReference type="FunCoup" id="F9XDT8">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDT8"/>
    <dbReference type="GeneID" id="13401711"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73357"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.519"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDT8"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
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    </dbReference>
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        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="18">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="565"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="799" mass="92073" checksum="53C47037B39E00F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEG4</accession>
    <name>F9XEG4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_110011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851643.1">
        <property type="nucleotide sequence ID" value="XM_003851595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEG4"/>
    <dbReference type="STRING" id="336722.F9XEG4"/>
    <dbReference type="GeneID" id="13401990"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110011"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_7_2_1"/>
    <dbReference type="InParanoid" id="F9XEG4"/>
    <dbReference type="OMA" id="KHVQHER"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58266" checksum="14CD8EDE3E109B0B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEI8</accession>
    <name>F9XEI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_73558</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851656.1">
        <property type="nucleotide sequence ID" value="XM_003851608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEI8"/>
    <dbReference type="FunCoup" id="F9XEI8">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEI8"/>
    <dbReference type="GeneID" id="13401903"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73558"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.679"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="F9XEI8"/>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
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    </dbReference>
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        <property type="entry name" value="HELICc"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
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        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="566" mass="62400" checksum="8A206BEA59D4C72A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEQ3</accession>
    <name>F9XEQ3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="32848" checksum="4FDFFDCEEF22E69B" modified="2011-10-19" version="1">MSPGLEMQYAVLGDARIGSEWRKANDLGEPRLPPVGAECLAVLQLPDLTTRQRISRRGWGVEVDIRSQEHGSSTSSKADADADVADGDTSGADDDNEENDNTNREDGRSGTGSHSTTVGKEQFLLIVHPRGRSTLVRATVPPLRQVDSMPEKCPAGSIECRLCLAYVPSHDMHKPCGFHPGRPVRLPHPSQTSSGVDANEQLLTPASDCTFGSVHVAEDSSTGPSDDHQSEWLNDNVSDDGKSEYDDFWKLRENWIYSCCNRPGNESGCMVEVSHMSEVADERFRDTWKIPRAEEDAADA</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="626" mass="70408" checksum="DEF31F814FF2E51A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEY8</accession>
    <name>F9XEY8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_73738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851254.1">
        <property type="nucleotide sequence ID" value="XM_003851206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEY8"/>
    <dbReference type="STRING" id="336722.F9XEY8"/>
    <dbReference type="GeneID" id="13395343"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73738"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.138"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007859_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEY8"/>
    <dbReference type="OMA" id="HGTMVAM"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="922" mass="101716" checksum="3791CBF9B4313C18" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFC2</accession>
    <name>F9XFC2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_45483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850654.1">
        <property type="nucleotide sequence ID" value="XM_003850606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFC2"/>
    <dbReference type="STRING" id="336722.F9XFC2"/>
    <dbReference type="GeneID" id="13397392"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45483"/>
    <dbReference type="eggNOG" id="ENOG502SN1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109893_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFC2"/>
    <dbReference type="OMA" id="RIFAHYV"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20602" checksum="1FF0887C181C9C41" modified="2011-10-19" version="1" fragment="single">RLQDHFINTMSVDVPETDPSTREFIRTQFMSLIFSDAASLHTLILLASSHYSKVRGQPSHSIDILQLRGMAIQEINRALVDCQPSGRATSDRMIAAVGKMATYELLFGQRDAFHTHMTGLQRLVAMRGGLQTLGLNGFLERTLLWLDVNAAQITGSPNLYFPPSTYPSTRGHPSPDRRLFVMGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGF3</accession>
    <name>F9XGF3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851299.1">
        <property type="nucleotide sequence ID" value="XM_003851251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGF3"/>
    <dbReference type="GeneID" id="13395286"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94232"/>
    <dbReference type="HOGENOM" id="CLU_1511791_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGF3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395632" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20100" checksum="843F37BD1C694463" modified="2011-10-19" version="1">MKLIVFTITALLPGLSLVSGAKTWAKGKKGMCCKSTLDACHKLGYWGCAVSDRSYCVRETSGLHGPTAWCNESCLESENSEGVDARDAKDYITDGGAFEPTLSVHDKSRIQVARLVLADESYFYRRPRLDYPDDALRRSYTCRHKEQTYNLMRIRRLIFRISSILVPYTKLPSTNFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGP8</accession>
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        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_94670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851021.1">
        <property type="nucleotide sequence ID" value="XM_003850973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGP8"/>
    <dbReference type="GeneID" id="13397761"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94670"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.596"/>
    <dbReference type="HOGENOM" id="CLU_625862_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGP8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="438" mass="48253" checksum="128ED7572AC7F9B7" modified="2011-10-19" version="1">MASPPSGAMEANAPIQDHNINDTDTAAQDSTLNDMDTSTRADAANETTAAVNEEELNEANTAVQNDQLAEMGVTGESNSAPLQDLPPPTQPARILPNNIDRQYVQELRREQERAFRIHAQREEARNARMEDLTNREDDSSTETGFAGHENEANGNGTAAQYGSHDETNTPVRGDGPGDSDHSPNNARTVAIGAGNGRLILIDRFWASDEQNTPAPDFNWRPFPIEIPSIEQSANGLTPLQLAAFLHWQLHQESMWAHNVGGIQDDDDNFYNPFTDDHPIQSWISFSAAMELYLRGLPLYNDIATEEQVCASMPKRTIHPEEAPQHPTADEAENAAISSVHRRIVQELKDDCKICGEAVPADKMWYLTKCGHVGCQGCVIKWLKANRTCPWCRREVDHEGSILVELAVAESKPKGCAVKRKADEADMGVDDRDAKKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGQ0</accession>
    <name>F9XGQ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94672</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850823.1">
        <property type="nucleotide sequence ID" value="XM_003850775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGQ0"/>
    <dbReference type="GeneID" id="13397759"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94672"/>
    <dbReference type="HOGENOM" id="CLU_597458_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGQ0"/>
    <dbReference type="OrthoDB" id="10640882at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51837" checksum="E97219EB5B69E231" modified="2011-10-19" version="1">MASSHLDNFVLCHALIYQILHENGERIETNDLGDELIRLVGEAEWIEGETRIAHLVEALKTEDRVRLADIPEKVFAYAMVYARDSRAWSRLQRPLERLARDHWNDHTAHLRREHDRITRDSGKTKSKPRALYNPSYRPLILAGSANRPAAQRRNKQGTGDPYEGLALKARDVGFLGRLRRGIARCVLGGGSFPDDRSSNDTFPKTLVHEDSLQINAIGYPARTTASLPLHCALTLTSPAEKTFAVPELGAKILAFLPAVEILPVRRVSHALKDVISSCPILQLALFLRRDDQVLAGAQVERTKMPAEIRWTLYRAPDGDFLNNLNHLVRPNPFVFVLPPSIDSVWQTLALRAKFGKHLRAEDWQPRHGIAMEMFISQPTVRSISVGITVEMGRSSFRLTWGTKLVVDGGIKVKHLVELVRELVLEEQDNSRRSKLERTLKEGNFLIRFREGYEVLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGS7</accession>
    <name>F9XGS7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851007.1">
        <property type="nucleotide sequence ID" value="XM_003850959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGS7"/>
    <dbReference type="GeneID" id="13397576"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94700"/>
    <dbReference type="HOGENOM" id="CLU_799752_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGS7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="347" mass="39610" checksum="E88FA1318D12A485" modified="2011-10-19" version="1">MSTLPGRHFIQSQALLYQMLHESDARWEANDLANRITEMVGEQAWDEEEDRIDTLLNGMAINPCYTRNDVSEVVTGLALEYHNGERAWSRLQRPLERVGTVYWRDHARQLEADHKKAGLPWNPSSLPTFQPLSTQVNPAYCPTSKKCKYCGTSHSQHLGLKCPSGRFLKRMRVRLGRMLLGRQFDFVARPPGAADCVDVVERILIRNHIDGRWRMFSTNHTAHELMRVMSLCKAQAASLVSLVAEYDSEQDRISQSRHTQAALIAESVHQDNGDDLILESVQYYLVFLDYLSRTSLLAAKFEQTLATLRYIQQTMATACSTLQWRLLYLQGQRGRLNPSPIDESSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGT5</accession>
    <name>F9XGT5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851005.1">
        <property type="nucleotide sequence ID" value="XM_003850957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGT5"/>
    <dbReference type="GeneID" id="13397582"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94708"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.648"/>
    <dbReference type="HOGENOM" id="CLU_855809_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGT5"/>
    <dbReference type="OrthoDB" id="10342745at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="325" mass="35052" checksum="7FCEAF3E7BE3A6F0" modified="2011-10-19" version="1">MVHSIVRRPTELPREQHRSQNFFAFGSGTGDEAPRPYHVFGKAQTGTNTNLPTTYHGRRRLSTDASRLLRSLPSSTMPPPSLSNRPTITSTRKLLPLLAFVKLHLSAPPKTSLSTGENITPSSTTSGAFNRVQPSTANAMIPSITNQAAPPRVFDQLEMIHASLIRGTTLAPTYNFSTAGQPILSTGPLAPLYSRGGVVIRITAETGLQHDVILCDTDLCPICSRHGIGSENPGPSQFNGLPFCHVDDVRSDVPREVLRPGRPGEEVDFVAVGGATSTSVEVRCEMEEAVVQFQAGRRDVIVRALVCVEGKCEMCFGRGPDPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGY8</accession>
    <name>F9XGY8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_95034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849962.1">
        <property type="nucleotide sequence ID" value="XM_003849914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGY8"/>
    <dbReference type="STRING" id="336722.F9XGY8"/>
    <dbReference type="GeneID" id="13402756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95034"/>
    <dbReference type="HOGENOM" id="CLU_804629_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGY8"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36962" checksum="375253D35F1D22F8" modified="2011-10-19" version="1">MLRNDPKYTCAARLTVGSNIGPALFEDVETRTKAPACGTSGSVAARAPAVTPVIVRPPSPFNAPNGPSRAGGKARQVPPRLDRLLPGEPLALDIEFGHTRYDGSKTQYTRLGWAAAVNIKNEIVLEVMVSYPHKPKVTLAFPSHTKGCGVDFHHIKPENGAVDSEDGGEDGDMAAFQHLDPFKGASEVVDTQQMYSSGRGHNPGLQTCAAAYLGRSIQQDGHTPVEDATATMELYLLKKPYDRAAKKAKLIGEGKKTISGPRQLVLAAVDDTEDMADATTIKDAADMVVTADTRRLVEMAAEAREGQITRKAAAAVAEYMVSQVVVVVVVADLDKMELARVYPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHC1</accession>
    <name>F9XHC1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_62030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850184.1">
        <property type="nucleotide sequence ID" value="XM_003850136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHC1"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="221"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="596"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="813" mass="89692" checksum="8B168493B2315135" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHM0</accession>
    <name>F9XHM0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_105431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHM0"/>
    <dbReference type="SMR" id="F9XHM0"/>
    <dbReference type="STRING" id="336722.F9XHM0"/>
    <dbReference type="GeneID" id="13394898"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105431"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.351"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058649_0_1_1"/>
    <dbReference type="InParanoid" id="F9XHM0"/>
    <dbReference type="OMA" id="VRIYGLW"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33332" checksum="E83E7D3175DE0689" modified="2011-10-19" version="1">MPPKRKTARNAQHQPQPTVAIQSDYETDTANYTDSQSMAIVPPPPVRSNAELNLLVLRRWCPEIEGIIAVAPFAVLYLFSPETQGWEKCETQGSLFVCQLGGELYPRYRVVILNRKNPENFQLDIVSTENIEITEEYVIVQIVGDDGTPHIYGIWIFSDGDSVPDTREVIAKTIMDCAMRAEQDALDAKGQHEQDGHIESHTEPEVIPEPTAPRQQLAGQQIDLATLFAKPPMQPEGQIQPLLQPHGVSGPHHTYEYAQGQQFGAPATESFQIHQTAHQAAAPPSQQNALLDLFKNAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHT4</accession>
    <name>F9XHT4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_94883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849870.1">
        <property type="nucleotide sequence ID" value="XM_003849822.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13395196"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94883"/>
    <dbReference type="eggNOG" id="ENOG502T0XG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255001_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHT4"/>
    <dbReference type="OMA" id="KMNEECD"/>
    <dbReference type="OrthoDB" id="3649145at2759"/>
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        <location>
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            <end position="21"/>
        </location>
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            <end position="175"/>
        </location>
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            <end position="278"/>
        </location>
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            <end position="492"/>
        </location>
    </feature>
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            <begin position="863"/>
            <end position="882"/>
        </location>
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            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84846.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1390" mass="144641" checksum="0D5F095214C42A6C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHX9</accession>
    <name>F9XHX9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">MYCGRDRAFT_74826</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 115943 / IPO323</strain>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="364"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="463"/>
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        </location>
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    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="669" mass="72914" checksum="6C1F7DCB37196459" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIV8</accession>
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        <recommendedName>
            <fullName evidence="4">DUF4385 domain-containing protein</fullName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17580" checksum="8DC6307D84997C9E" modified="2011-10-19" version="1" fragment="single">RMSYAIARGEVGVLSFEPYKSILLPHWRFRTVPIAKKSSQTLKSAFDHYVRSEDLVGADMARKFIQMGMTRARRYANYKGGRKYEKSEKELEAEGKVKADRVRKEKSAGHDGREEKAAASEVFKEVWRECIEDEGYVRLKEVWKKEKKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJZ9</accession>
    <name>F9XJZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_48009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849731.1">
        <property type="nucleotide sequence ID" value="XM_003849683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJZ9"/>
    <dbReference type="GeneID" id="13402528"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48009"/>
    <dbReference type="eggNOG" id="ENOG502QV5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033734_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJZ9"/>
    <dbReference type="OMA" id="FVIYFPR"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32744" checksum="C3059866053CA17F" modified="2011-10-19" version="1">MEDLQPHCEHLAHPHWFPVTLASVLVIGILISYLPQHYKIFARRSSEGLSPWWVLLGGISSIAAIANILVLPASRRDMSCCKELEGGACAAALLGVAQIGVQFTSFMIIVLLFLVFFPRSEAEVQDLTASTASLTHSNPAKRSDQLIVGASIFVSLFAVLMVSLVLVFRIPSKTQIWADALGTVSGVLAGVQYLPQIYYTWVLKDLKSLSMGTLVIQAPGAFLFAFSLWQRVGWEGWSTWLVYIVTGALQVVLLVMAVRYWSRSKEGDASNYASEDEQDIPSERTTLLPKASRRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKA8</accession>
    <name>F9XKA8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BXL</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_75584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849403.1">
        <property type="nucleotide sequence ID" value="XM_003849355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKA8"/>
    <dbReference type="GeneID" id="13399099"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75584"/>
    <dbReference type="eggNOG" id="ENOG502SM7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKA8"/>
    <dbReference type="OMA" id="MWSEDDT"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18828">
        <property type="entry name" value="GH43_BT3675-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395660" description="Endo-1,5-alpha-L-arabinanase A" evidence="8">
        <location>
            <begin position="22"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="673" mass="73180" checksum="568666A46A121332" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKN5</accession>
    <name>F9XKN5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848845.1">
        <property type="nucleotide sequence ID" value="XM_003848797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKN5"/>
    <dbReference type="GeneID" id="13398621"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96183"/>
    <dbReference type="eggNOG" id="ENOG502R6IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892000_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKN5"/>
    <dbReference type="OrthoDB" id="3650688at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="312" mass="34912" checksum="364D12A1FD630D9E" modified="2011-10-19" version="1">MDKSNSVIGNINPMPQPTAMSPPAAKPPPTTMLSPKVIPSPRSMPSPWDMPPANAVSPSKAMPSTSVMPPPSIMGPSKLPPFSQRKVSAARDDLMLQMNDPELDELIKELQNRQRKNRAIGTSNQNCGLLKLPAEILNYIYEDVAADAYGKAVTPHLTDEQGKKVRPSLLGTCYQIYQEFSGVMWSPKYMRAKMFGGQGQSLVVTEPRLLHAIVNELLSSLMFDTRRTHTTNPTEHCQEDVDRHLYQHANAWIGYITSQCPGAFEYWSKFQIHVANTESDLGKLSMKHRPGDFIRIQGLTFLIKDKDKRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX9</accession>
    <name>F9XKX9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_101338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849230.1">
        <property type="nucleotide sequence ID" value="XM_003849182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX9"/>
    <dbReference type="FunCoup" id="F9XKX9">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKX9"/>
    <dbReference type="GeneID" id="13398777"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101338"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.46"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_2_1"/>
    <dbReference type="InParanoid" id="F9XKX9"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="629" mass="69575" checksum="E210C13BB997CB74" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL68</accession>
    <name>F9XL68_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849111.1">
        <property type="nucleotide sequence ID" value="XM_003849063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL68"/>
    <dbReference type="GeneID" id="13398583"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105966"/>
    <dbReference type="HOGENOM" id="CLU_2795894_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL68"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="68" mass="7216" checksum="6015F35F5631E2EC" modified="2011-10-19" version="1">MYIGECSVGPYRPGLDKCAVTRMVQIGVGHVAVAAVRRGTTMRTSSSVPPVHFIPSTPLCCLKPSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL69</accession>
    <name>F9XL69_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Srf1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="129"/>
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            <end position="164"/>
        </location>
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            <end position="219"/>
        </location>
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            <end position="839"/>
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        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
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        <location>
            <begin position="898"/>
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    </feature>
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            <end position="997"/>
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            <end position="310"/>
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        </location>
    </feature>
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        <location>
            <begin position="388"/>
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        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
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            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114194" checksum="AB9D3A4A21207D23" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLH3</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">MYCGRDRAFT_25609</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
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        <subcellularLocation>
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    <comment type="similarity">
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    <dbReference type="eggNOG" id="KOG0534">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </feature>
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        <location>
            <position position="76"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
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            <position position="85"/>
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        <ligand>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="32475" checksum="3D7251367ABEDC13" modified="2011-10-19" version="1" fragment="single">PGEFVEYTLIGKENVSSTCAIFRLRPASNVVIDLDDPSTERAITSVEFKQPQLQIARSYTLLPQAPGQPMDELRFLIRKEQKGEVSNFLHRLPPGSNIEIRGLRTEYQMPADITTALFLVGGTGIAPALQAADHLRGEADMHILWASRRKEDCVGGSNDSEPAKRVSSWWQSVASTDTKANAVDLPNAEKGALVSLLESLKSQAAATEEPSHRLVVDYFVDEEGSAVKPEDVKRLLTSLSRADSSAEGGRKLLLVSGPPGFITYWAGSKQWVNGREVPGPLRGVLSTLDLGGWEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLN5</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_63029</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848834.1">
        <property type="nucleotide sequence ID" value="XM_003848786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLN5"/>
    <dbReference type="STRING" id="336722.F9XLN5"/>
    <dbReference type="GeneID" id="13398004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63029"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028866_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLN5"/>
    <dbReference type="OMA" id="GYMKQYD"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="217"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="40734" checksum="0C00B5A8B9CA44ED" modified="2011-10-19" version="1" fragment="single">MTGTGRVLRVGIVGAGEVSQVIHLPVLSLLSHLYTVTAICDLSRKNAEHCASKFHIPLVTTNPGEVFQSTNVDVVFVLTSDEFHEPYVTAALEAGKHVMVEKPITLSLPSAERILAAEAKANGPIVFVGYMRRYAASFTNTFKREVASIPRILYARVRDFSGPNAKFVNESGTFQVKNVDDIPSTAGEERTQRLEALYKEAFPGQTITQEHKSLNRFMGSLGSHDISLMREVLGFPESVAGISVNDPFYSAIFNYRNKTGESFACTYESGIDAVPEFDAHLAVYGQHKRVEIMYDSPYVKGLPIKVKVWELNEAGEMQTREMIGSYEDAYTAELKELYQCIVDGKSVKTTVRDALQDLKLYDMMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM02</accession>
    <name>F9XM02_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848422.1">
        <property type="nucleotide sequence ID" value="XM_003848374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM02"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96752"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.381"/>
    <dbReference type="HOGENOM" id="CLU_754802_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM02"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="367" mass="42539" checksum="ED1B612912DE0985" modified="2011-10-19" version="1">MQQVRYNPDHSGHVPRRAVSPHSQEHNFKIYREYLVRRIKDVTQGSEPTSFFTDSQLPLLQGDAAEWDKTLLEHILDLAIEVAEIARTDFNSNMSEADNIQHYVRFARSWMYEYEQMRRLWRSEADVQNAVKECRAAVRTWWRNRATEVANEERKQRKESIQQERKEAMESLVALIRTSISRSPADVMDVWEGIEEQIDQCQGTLTEEVKESIAKEFARMWKHVQAPRRTGWIFHSTKPRPKGCQAKVAVTWKIPPGGEYDSEKGHITYETSHAYTEFYRHDTYPWSPDLKDPPETITPFLIDPIKVRFSTTTLNGKPTKGEVALKPREIEAQDVRRALALRSGARSEANAEVSQTSSTSSTWSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM52</accession>
    <name>F9XM52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_111338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848535.1">
        <property type="nucleotide sequence ID" value="XM_003848487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM52"/>
    <dbReference type="FunCoup" id="F9XM52">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XM52"/>
    <dbReference type="MEROPS" id="C14.035"/>
    <dbReference type="GeneID" id="13396187"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111338"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.437"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="InParanoid" id="F9XM52"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="410" mass="45305" checksum="0C9C3364CBAF4580" modified="2011-10-19" version="1">MSGFPGQNYHNQAGYPPPQPYNNGYPPPQQYQQPYGQPPPPQQYGSYGGPPPPPQYGGYQQPPPPQQYGAPPPQQFQQQRPPQGYNRPPPPPQSQQNFGHGAPSGYTFQYSACTGRRKALLIGINYFGQKGQLRGCINDVKNMSEYLNGHFGYKREDMVTLTDDQQNPMSQPTKANILRAMSWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHIVDDEMHRIMVNPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGVLKEPNLAKEAGQGLLGIVSSYARGDLGGMASTAMGLFKKATGGRDTYERNLQTKTSPADVIMWSGSKDSQTSADANIANQATGAMSWAFITALKKNPQQSYVQLLNSIRDELEAKYSQKPQLSCSHPLDTNLLYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMG6</accession>
    <name>F9XMG6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848270.1">
        <property type="nucleotide sequence ID" value="XM_003848222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMG6"/>
    <dbReference type="GeneID" id="13396569"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106049"/>
    <dbReference type="HOGENOM" id="CLU_2063337_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMG6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="13853" checksum="2603E8744129F8E3" modified="2011-10-19" version="1">MSHERMARSVDRDSLCVRYYSWSCWLPRTSACAPIGLAQRSVAWRCLLMVRVEGGMTSLTSSNDPDQRNSACCRKDRYLMQKGIDRFASSYWPGRGSRIEHHCMLRDLGLWTRDVVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMK6</accession>
    <name>F9XMK6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_49728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848291.1">
        <property type="nucleotide sequence ID" value="XM_003848243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMK6"/>
    <dbReference type="GeneID" id="13396107"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49728"/>
    <dbReference type="eggNOG" id="ENOG502S2VF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_2_1_1"/>
    <dbReference type="InParanoid" id="F9XMK6"/>
    <dbReference type="OMA" id="CIVQTRY"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="271" mass="30349" checksum="6C0D053E512294E8" modified="2011-10-19" version="1">MPWVPHSSPEITSEAQWRSVVATILAFTGVALLAVGLRFWVRRKGLMIEDWVTLGTMILSLGFVTTSIIRESHRLGLEQHTTNSEHQKPYLVANYVAWPLYLWGLAGFKLALCIGYLRLVKGSLGSWHRIFIVGVATLSSLIHTIFVIIYLFPCRPLSRIFDASVEGSCLPYAAINYTVSATVISLDIIIFLLPVPLIQRLKLDRTVKIGLTVTFSLGLLTTVLTIMRATQINRIVYGDGNTTHFVVRGTLELNIGVRRYFVRSKRCSALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMQ2</accession>
    <name>F9XMQ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_63538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848311.1">
        <property type="nucleotide sequence ID" value="XM_003848263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMQ2"/>
    <dbReference type="GeneID" id="13396378"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63538"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.121"/>
    <dbReference type="eggNOG" id="ENOG502SHKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="InParanoid" id="F9XMQ2"/>
    <dbReference type="OMA" id="CAYGHLK"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390887" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="450" mass="47883" checksum="09B3ED121E97825A" modified="2011-10-19" version="1">MVGSKVLSAALLLNGVVAFPHIAEMVAKQQLEERQELGTLVPFPQYPGSPSHALYNDFDPSTQLVSTSGDHEFRAPGDSDIRGPCAGLNAAANHGYIPRSGIMTAEAINTGLWEAFSLDKTATIFLQTATMFFDGDPISGKWSIGRPPPNGLNSLGALGDVLGKSSGICGGAAHLKTEGDASITRGDYLAPTMNSNCRSYPQFAQELLDLAQKRENGNISPRVLAEHSYNRKKYSIANNPNYYSPAYAGVAFTFGAHMFAHVLLANHSAEQPRGFLEPAVWKAWFSYTDGPNGELIQTAGHERIPDNWYKRAPADAWTLSDIVTSTAQQCAAYPSNCQVGGNTGKVNSFSGVNLGDISGGLVNSATDLSDPARMGCFIRQMIQANTPSFLANTFSGAILDQMNNLVKTMLDPALDLLGNCPNLPAGKSVDTYDSKFPGAQNPAGGSAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN25</accession>
    <name>F9XN25_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848363.1">
        <property type="nucleotide sequence ID" value="XM_003848315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN25"/>
    <dbReference type="GeneID" id="13396278"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96650"/>
    <dbReference type="HOGENOM" id="CLU_1157189_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN25"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="240" mass="27594" checksum="F4AEE8519517EF8D" modified="2011-10-19" version="1">MKMSDGMRKADFNDESFSDVKIEIYTGVDDQSDRRSFHCHKLVLKKDSEVFATAFNKNSRFADANSAVYKVFEEDLDGIEAYLKGRYGIAPSDAETADWEFMLKLAYIASKYGNSKAAREYWDDFRAAFKKVWDNTRPTAPKQAEEMLKKLLLCEDVAFEEWNSTTSKGLLELVGLRYVRNNHNGLIKDDDFYEWISGYPRLWRKCLAAFTAVAALPDAIRMSYGGAVDEIKYGRRRQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN73</accession>
    <name>F9XN73_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosylphosphatidylinositol:protein transamidase, GAA1 component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_49312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848386.1">
        <property type="nucleotide sequence ID" value="XM_003848338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN73"/>
    <dbReference type="FunCoup" id="F9XN73">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN73"/>
    <dbReference type="GeneID" id="13396267"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49312"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_3_0_1"/>
    <dbReference type="InParanoid" id="F9XN73"/>
    <dbReference type="OMA" id="MAIALWM"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="65852" checksum="D2FDD3DFFAAB0637" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNB4</accession>
    <name>F9XNB4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848409.1">
        <property type="nucleotide sequence ID" value="XM_003848361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNB4"/>
    <dbReference type="GeneID" id="13396169"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106171"/>
    <dbReference type="HOGENOM" id="CLU_2075007_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNB4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="11742" checksum="032048DAF35E5790" modified="2011-10-19" version="1">MPGVAKPLVTTEALLARSVVAGSSAVTGGNVPDDTDDMVLGSEDTVLLAVAPPTTLGDVPVDALSEAEELGAEEVLPGCWLPLAIISSAEMSLIDVEMGSLLGAAGVLAVVVSKTSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNJ3</accession>
    <name>F9XNJ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_101727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847903.1">
        <property type="nucleotide sequence ID" value="XM_003847855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNJ3"/>
    <dbReference type="FunCoup" id="F9XNJ3">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNJ3"/>
    <dbReference type="GeneID" id="13401757"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101727"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="F9XNJ3"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP82879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39888" checksum="282F57D95D56E454" modified="2011-10-19" version="1">MSSNSDGRPTQLPPTSDLAQITTFPRLALWLTRRDPSAINSFAGAMAGVASGIVTCPLDVVKTKLQAQGSFAKPNHNNPLLTKNPSAVYRGMSGTMRVIVRQDGVLGLYRGLGPMLLGYLPTWAVYMAVYDSSREYFYANGYNERTRDKWVARIYASVAAGACSTLVTNPIWVIKTRLMSQVSKTASDGARTPWHYSNTFDAARTMWRAEGLKAFYSGLTPALLGLSHVAIQFPLYEYFKQEFTGAEMGSTVPTNSASDTASNTLGILAATFLSKLCATTATYPHEVLRTHGMAYQPRYAGVTSTFKTILREEGWRAFYNGLGTNLIRAIPAAMTTMLVYENVKAGLTGLRQEGLEMKERGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP71</accession>
    <name>F9XP71_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848070.1">
        <property type="nucleotide sequence ID" value="XM_003848022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP71"/>
    <dbReference type="GeneID" id="13396036"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106410"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1826829_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP71"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="141" mass="14952" checksum="E9F85C54A225B9DB" modified="2011-10-19" version="1">MEARQAELLGIPRQTSFSSTATSPSAAEATSPSAMDLTSPINPTNHEFAFLLTPHLPYEPDFATTFSTLCDTLIDTYAKLLELITGPEACNGQVGAEFVKADKAIRKVLVVNAVRELEEGTRTGLKAEVGGLGKLVLGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPI7</accession>
    <name>F9XPI7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_106278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848216.1">
        <property type="nucleotide sequence ID" value="XM_003848168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPI7"/>
    <dbReference type="FunCoup" id="F9XPI7">
        <property type="interactions" value="1046"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPI7"/>
    <dbReference type="GeneID" id="13401802"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106278"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="F9XPI7"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="39486" checksum="59B7063140D3511B" modified="2011-10-19" version="1" fragment="single">MAPIQKECDYLVIGGGSGGLASARRASGIYGQKTIAVENKRLGGTCVNVGCVPKKVTWNAASIRETIHEAKNYGFSVEETKPFDWNYFKNKRDAYVKRLNGIYEKNLKNDKVEYLHGTATFKDPHVVTVTLDDKTEIDIKAKKILVAVGGYPNLPPVEGAELGITSDGFFELEHQPKRVAVVGAGYIAIEMAGMFHALGTETHLFIRQDKFLRTFDPMIQDKVVAEYERQGIILHKNSSQSKLEDAGNGKKTLHYKDSNGEGKLEVDTVLWAIGRAPELEKLNLEASGVKTNDKKHIPVDDYQNTNVEHIFALGDVCDKGFELTPVAIAAGRKLADRVFGGKKDARLEYENIPSIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPL6</accession>
    <name>F9XPL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_77658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847512.1">
        <property type="nucleotide sequence ID" value="XM_003847464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPL6"/>
    <dbReference type="STRING" id="336722.F9XPL6"/>
    <dbReference type="GeneID" id="13400614"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77658"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPL6"/>
    <dbReference type="OMA" id="PMKHRER"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="27673" checksum="23CB6E90ABB4409B" modified="2011-10-19" version="1">MAELLIGTAFITGAASGLGRATAFAFAQHGITNLALIDLDPTALESTKSDLIQKFPKLNVLVLVSDVRSEDAVARAIADTVSQFGRIDAAVNNAGISGGSFALTQDASWEDWSRIYDVNIHGVWRCQKHELKQMSGQELIETNKSRGVIINVASVLGLLGGNATTPVAGYSSTKHAVLGLTKTDAICYATQGIRVNAICPGYIDTPLLQNLDEATLQRIVSKIPAGRLGNPEEIGNAIVFLASYLSSFMTGQGLVVDGGQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ57</accession>
    <name>F9XQ57_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_64667</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847735.1">
        <property type="nucleotide sequence ID" value="XM_003847687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ57"/>
    <dbReference type="FunCoup" id="F9XQ57">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ57"/>
    <dbReference type="GeneID" id="13401175"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64667"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.230"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ57"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP82711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="126" mass="14681" checksum="C0784FB1C9E228D4" modified="2011-10-19" version="1">MLPVRVSRTALPAFRRSMQRRLQSNVGTQNNTFNKERQAVKDHAAATSDLWRKLSIYVVIPSLILASVNAYRLWNEHWEHVAHGPALEDKVEYAFQNIRTKNFFWGDGDKTAFWNPKVNYHKPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQB5</accession>
    <name>F9XQB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_64763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847709.1">
        <property type="nucleotide sequence ID" value="XM_003847661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQB5"/>
    <dbReference type="FunCoup" id="F9XQB5">
        <property type="interactions" value="811"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQB5"/>
    <dbReference type="GeneID" id="13401040"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64763"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.297"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="InParanoid" id="F9XQB5"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="82" mass="8881" checksum="8CC5977A526E5FE9" modified="2011-10-19" version="1">MVLAVDLLNPTPQAEARKHKLKTLVPGPRSFFMDVKCPGCFTITTVFSHAQTVVVCAGCSQVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQQ9</accession>
    <name>F9XQQ9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_27363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Waalwijk C."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="227" mass="26063" checksum="74CB091077724A9D" modified="2011-10-19" version="1" fragment="single">FTCSNGALTTADYLMSDCIGDKIPKDPDVLADFGYFPWFVENRPLIFPPVPQIHAVTDNDISEHYYKPAKFLLEPRDRLKPVKSLEPSTKRDCFIFAALIIQSQHPSPELHGPYYDFGFCACRNEAEESTLGVLYQQLIVGDIHQPQRWYWGDMPTSDAYAARFSDFCQAFENQDLIQFMDNNGMKQQRSSIRHLETYLNAPKETRHSPVWKLLTFLKSGDAECPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Zymoseptoria</taxon>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="141"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="190" mass="20525" checksum="7436DFD984A7F5FC" modified="2011-10-19" version="1">MNPDTPPVESYHHVQYVNPVHIWSLPQTPLLPQSLSLPRLQPRPQVLIDQTVKMGEGSSNSPHCLDDMLALPHSRNAQPSTTDVKATPASVPPSPAFDFSFSLCPFSVPSRPQPDFDWEAVSIVHGPPSSTQEASVSSTDGDTAPASAQHAFTNRGTATSTSLYPPQELSKPMESGCMGRGTASRKRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="44767" checksum="F27CF944743A8542" modified="2011-10-19" version="1">MSRPTAGSAVPSSNAFDGGMLWHRPLVHGCNTLSRSSARNGEDMSFLRSSLAALDPDDFISQREYAALVARRFSTSTTPAGSRRAAHRPSQALTPPLRQRRRNSSGDFQTLSPVYAHGALSQEITLRSALVSARPFRFLRYEHQHIEPSVPTAPSSLQTIGDPIILDQFLAALHYLNNAPSTSPSILLRQGTPRVFIEPLLRVRGIDHEVAINESLRRIIKHIDTMGRLDGDIDILDICHATMVYSRPLRTTGSLMPMPMPIKTITRAKADRDEVEVEAKAKRLHGKRRDDDPLQRSGDEVKYRSYHRNILDDRATVGNDLNGSQDNIDPLTGTSPSLAVLLSDSSGEPVRTISRARQLCCGSWVAAGIAEGEETRASRADFGQLPAVGRAKGPASMPVVNSDCERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRJ2</accession>
    <name>F9XRJ2_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847182.1">
        <property type="nucleotide sequence ID" value="XM_003847134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRJ2"/>
    <dbReference type="STRING" id="336722.F9XRJ2"/>
    <dbReference type="GeneID" id="13399674"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51731"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2819755_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRJ2"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="67" mass="7646" checksum="D9F424BE4666C9DD" modified="2011-10-19" version="1" fragment="single">KDKEDLEEISGELGLADEDHKVLYKIDDSFFSLPVPEVQELLSASVERNDSEVEKAEEYANPRKHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>F9XRY1_ZYMTI</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847045.1">
        <property type="nucleotide sequence ID" value="XM_003846997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRY1"/>
    <dbReference type="GeneID" id="13399204"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97974"/>
    <dbReference type="HOGENOM" id="CLU_2075014_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRY1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="13449" checksum="9CF3582CA4672988" modified="2011-10-19" version="1">MQKLELKEQKLDTEKQDITQKAWLARYTKPQPRSVNEPVLKIGLQLFAELAKHDWRIYMGSQPRRESIMACANLRAAPINTGFDAKSAEVQASSKILSTYAQATTCDLFDTTKRFDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRZ1</accession>
    <name>F9XRZ1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847028.1">
        <property type="nucleotide sequence ID" value="XM_003846980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRZ1"/>
    <dbReference type="GeneID" id="13399423"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106691"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.72"/>
    <dbReference type="HOGENOM" id="CLU_2110858_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRZ1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="13558" checksum="484BE0E587133AE5" modified="2011-10-19" version="1" fragment="single">MRRTSLRHLPALALFIRSNLWNRNYQRFTSRRCTYNPSYCETDISLPSTWSATLALLGSRRGSQTAFLISSRRRLSVEQRKKMKEEREEEVWDSTSDGVISRLPPRRGFRGRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS73</accession>
    <name>F9XS73_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846950.1">
        <property type="nucleotide sequence ID" value="XM_003846902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS73"/>
    <dbReference type="GeneID" id="13396740"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98062"/>
    <dbReference type="HOGENOM" id="CLU_318370_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS73"/>
    <dbReference type="OrthoDB" id="10470220at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="914" mass="102031" checksum="7AE9FCFECF560E98" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSD1</accession>
    <name>F9XSD1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106723"/>
    <dbReference type="HOGENOM" id="CLU_2747215_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSE0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="71" mass="7645" checksum="77704F93B9442730" modified="2011-10-19" version="1" fragment="single">MSAPAPSTPLCSSWSDTTPTARDWRSLRDVITTFCSNGDDLMTTASSDVLEHSIAAQHNAQALTTMLAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        </lineage>
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                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
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            <authorList>
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                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABU40266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="473" mass="53756" checksum="86FFB103200AA745" modified="2008-02-05" version="1">MSVSNYSILCSYLFTWVVTRTPRYWFISTPFISNLNAPLYLLTIISLVVPMVFIAKILVKVFKTLIDSRIILCDLHTIALFFTILTQHELCRKSNYNVRNYHVGNNIILLSAVFPLLGISFNTDCDPDIIHCSLGTYDHISDPPGQYIQPVVYNPNCESSDTVHDVIAKGYRLQDLGDRENHKCDIEGSEWVKVDNTRMYKVSYLKGRFTSSLAQLGYISPMTNYLPYAFALDTPDYYLNQVGVHNAIETMKASNKVEPLVDAIVTTTFGHLSSASDGYTLEPQPRASKMPKELKKPDFRLLYNNKTSFISEHKSHDGDSWFDALAQVKRYGMKFDDATRVYCLVFKGKYLSAFLYEEDYHASRGFSCKSEEIEDLLGITVTRHGLSLMAQQNVFYPQFNAYDYTSTGSVSDKIASKAILSFFGNIRNTDLDTEDLDLPELPDIGCRRIHLGIAANIIRQTVDIEGNGRFIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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    <reference evidence="2" key="1">
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                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
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            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EU090238">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5I0"/>
    <dbReference type="InParanoid" id="A9Y5I0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABU40267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="21470" checksum="F4D3A11B1B9DB75B" modified="2008-02-05" version="1">MWVQISFTLLMQLLTYLLLIISNALIMSRDKSSLFHEIVLYSIKPIGTVVYILIMVMAFILVFVLMLSLILKYKKSAAILTYIAYIIGLQNACLNNGLGIDIFYSYDGLIVGAIIISSALTLRVVLYNLTINNRTTITSLDLVFDLSNVIHNKYNKLKKRIITIFTRIYHKCLFLIILFYVLIYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW51</accession>
    <name>F9WW51_ZYMTI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855974.1">
        <property type="nucleotide sequence ID" value="XM_003855926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW51"/>
    <dbReference type="GeneID" id="13403246"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88845"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.309"/>
    <dbReference type="HOGENOM" id="CLU_2279697_0_0_1"/>
    <dbReference type="InParanoid" id="F9WW51"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11620" checksum="516DB37109294A9C" modified="2011-10-19" version="1">MAGQVVSILVLVAQPQPTVSRNLTRFRDFVFDEKWAQHGWYMNAWMDGLMKALLPIHKTLMNNTRLLAFDLRAIVLCPPTCPPMRLRSSAAQHPHRVAKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWF3</accession>
    <name>F9WWF3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857437.1">
        <property type="nucleotide sequence ID" value="XM_003857389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWF3"/>
    <dbReference type="STRING" id="336722.F9WWF3"/>
    <dbReference type="GeneID" id="13394621"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89270"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.827"/>
    <dbReference type="eggNOG" id="ENOG502SGK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_3_0_1"/>
    <dbReference type="InParanoid" id="F9WWF3"/>
    <dbReference type="OMA" id="NWHIHHD"/>
    <dbReference type="OrthoDB" id="2096797at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="14433" checksum="8FB21513596EFBD4" modified="2011-10-19" version="1">MQFIRSAHQQGASSIQGSKTFTGTAYIDPVFASADNGGCFCANVTFLPGARTFWHTHEKGQILSVTNGEGLICTAGEEPKRLRVGDVVYIPGGEKHWHGATATSIMTHMAIAMGGCEWHEEVDAEEYEKINSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWS5</accession>
    <name>F9WWS5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_66728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857165.1">
        <property type="nucleotide sequence ID" value="XM_003857117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWS5"/>
    <dbReference type="FunCoup" id="F9WWS5">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWS5"/>
    <dbReference type="GeneID" id="13399028"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66728"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1404"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="InParanoid" id="F9WWS5"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25650" checksum="13708A822B2464CF" modified="2011-10-19" version="1">MGFLDFVNDTAYSLLDSWVSTRSYIVGYGPSQADVKTYQALKSAPDADKYPHAARWYKHTATFESEFASLPGDPSKAHTAYGPESHELTVNPAKAPAKAEEEDDDDVDLFGSDDEEEDAEAARIRDERLAEYKKKKEGKTKPAAKSIVTLDVKPWDDETDMKELEAAVRAIEQEGLVWGGSKLVAVGFGIKKLQINLVVEDEKVSLDELQEKIQDLEDYVQSSDVAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXU3</accession>
    <name>F9WXU3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_31901</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <position position="1021"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY36</accession>
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        </alternativeName>
    </protein>
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    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="75" mass="8648" checksum="0D00F66603C8DF33" modified="2011-10-19" version="1" fragment="single">LPLEIIQYVENSRNPDIYTREFVELVMRYNQQQKGRSDAYAQFRDILGREMASAIPDLREDVRKVVESSGGQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY42</accession>
    <name>F9WY42_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_66394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857278.1">
        <property type="nucleotide sequence ID" value="XM_003857230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY42"/>
    <dbReference type="FunCoup" id="F9WY42">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY42"/>
    <dbReference type="GeneID" id="13402849"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66394"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1163"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_4_1_1"/>
    <dbReference type="InParanoid" id="F9WY42"/>
    <dbReference type="OMA" id="HVNDYCS"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="571" mass="63869" checksum="D4485B00CE88A51F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY73</accession>
    <name>F9WY73_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_98589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857264.1">
        <property type="nucleotide sequence ID" value="XM_003857216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY73"/>
    <dbReference type="STRING" id="336722.F9WY73"/>
    <dbReference type="GeneID" id="13394960"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98589"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1201"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="F9WY73"/>
    <dbReference type="OMA" id="INHPARW"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="11"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="380" mass="40543" checksum="0A5C7E4C017CA15E" modified="2011-10-19" version="1">MTTSIQASVLHAAKDLRLESRTLSPPAENEVQIAISSTGLCGSDLHYYSHFRNGDILVREPLSLGHESSGIVTSIGSSVSHLQPGDRVALEVGIPCGACQRCKQGRYNICKDVKFRSSGKAFPHFQGTLQERINHPAEWVYKLPDDVSLDVGALLEPLGVALHAWRRSLIKDVGSEATVVVFGAGAVGLLCAAVAKVKGAGKVVIADIDEGRLRFAVENGFADQSYVVPMKRGKDTEESLAIAKEVAKEVGEVDGLGEVDVVFECTGVPACVQAGIYATKPGGRLMLVGMGHPIQTIPLGAAALREVDIVGVFRYANTYKESIEIVQQAMKSADGPDFSKLVTHRFSSLAEAEKAFEMAGKTKDADGKLVLKVVIDSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYC5</accession>
    <name>F9WYC5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_34736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856544.1">
        <property type="nucleotide sequence ID" value="XM_003856496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYC5"/>
    <dbReference type="GeneID" id="13399000"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34736"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="InParanoid" id="F9WYC5"/>
    <dbReference type="OMA" id="PLWCFIG"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58338" checksum="C89131C444305A48" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYQ8</accession>
    <name>F9WYQ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_51997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855918.1">
        <property type="nucleotide sequence ID" value="XM_003855870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYQ8"/>
    <dbReference type="STRING" id="336722.F9WYQ8"/>
    <dbReference type="GeneID" id="13403857"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51997"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.193"/>
    <dbReference type="eggNOG" id="ENOG502QQMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049058_1_0_1"/>
    <dbReference type="InParanoid" id="F9WYQ8"/>
    <dbReference type="OMA" id="FRIRQWC"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="38"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="348" mass="39563" checksum="D445111E55B1007A" modified="2011-10-19" version="1">MVNMDSPHLVATSKVVVIVSLIVLFISYLIVSCPPPLPPTKSLRSVNFHFTRKCNKTCVFCFHTEKTSHIASDDEMKNGLRLLQQAGMVKINFAGGEPFLYPSKLAMLCQFCKEDLSMESVSIISNGTKITENWLRRYGKFVDVLGVSCDSFDEATNLKIGRGTGENVKTLFKIREWCRELGIKFKLNTVVLRWNWEEDMVETIKQLDPFRWKVFQVLPVGGENDATATETELDKRKRSVKDVLITDEQFESFCKRHDHLECFVPESNDLMASSYVIVDEYLRFLDKGNGEEKASASILDVGVEKAFAEVKWDKEAYEKRGAVYDWSKDREANVQTCGMSGANTGLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYR9</accession>
    <name>F9WYR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_78124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857722.1">
        <property type="nucleotide sequence ID" value="XM_003857674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYR9"/>
    <dbReference type="FunCoup" id="F9WYR9">
        <property type="interactions" value="890"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYR9"/>
    <dbReference type="GeneID" id="13403293"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78124"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.205"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="InParanoid" id="F9WYR9"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="86" mass="9549" checksum="E6926F2052BA3BB8" modified="2011-10-19" version="1">MENERGELVDLYVPRKCSATNRIIKAKDHASVQISVGKVDENGRYTGENQVYALSGFVRAMGESDDSINRLAQRDGFLKGVWSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY1</accession>
    <name>F9WYY1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_65361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857616.1">
        <property type="nucleotide sequence ID" value="XM_003857568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYY1"/>
    <dbReference type="GeneID" id="13403980"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65361"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.441"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="InParanoid" id="F9WYY1"/>
    <dbReference type="OMA" id="IANTAYC"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="32053" checksum="7E095DFBBDA61520" modified="2011-10-19" version="1">MAANWGTQGTGDFVPTSHATPYAATDPKTTALPAPFTVCIVGASRGIGAGIATSYAKAGASCLILSSRRVSGLEETAAACRAINPDIRIAVIPCDITSAQSVASLAKEVREQYGRLDVVAVNSGYWGPVVLTMTDTDPETFSNAINVNYTGTFLCAKYLTPLLLETEDGAKAFVGVSSFASLIVRGPIANAQYCVSKAAQLKLLEHVHEQYHGQGLATYAVHPGAVLSEMAEETAPDAFKPYLTDSQELCGAFCVWLTKEKTRVEWLSGRLLSAKWDVEELEGRKRDIVDGDLLKMKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ41</accession>
    <name>F9WZ41_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_89156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856150.1">
        <property type="nucleotide sequence ID" value="XM_003856102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ41"/>
    <dbReference type="GeneID" id="13394479"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89156"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.685"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556496_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZ41"/>
    <dbReference type="OMA" id="QIAYASE"/>
    <dbReference type="OrthoDB" id="3645278at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="172" mass="18325" checksum="B25E1A339D7C29E1" modified="2011-10-19" version="1">MTTPVYVVGCISLIVQLCYSDKVKKRGVFIISCGVPGSVGYLICVGSSNPGAGYAGMFVLVLGLYPISTLAVIWITNNLSPDSKRAVGMPFAYSIANLSNLVSSQLYPSQQGPRYVQGNAVSAGLTVVAGFLYDACWVLLRRRNMKKAKLIAEGATNNGLEGDQSLDSMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZK9</accession>
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        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855877.1">
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    </dbReference>
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    <dbReference type="GeneID" id="13403799"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88674"/>
    <dbReference type="eggNOG" id="ENOG502SUP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788026_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZK9"/>
    <dbReference type="OMA" id="EHNINEF"/>
    <dbReference type="OrthoDB" id="3648790at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="352" mass="39859" checksum="00CB9BB9B1FD4AA6" modified="2011-10-19" version="1">MGRPDREVMCLAANHGLDNKLTTKPPLAVAVCHCVTAFPQPQSTSDCHETKASNHTITTIAMAMESQTPPPYSTTNDGSLPYPDTAARNTLLTQLARQANLYYGPNWPADSPPEPHAALSRETERIRNMMEFTLSVDYQGYTGARICPADRVHFHRMVEAVCKLKRTVSLDKSDPEVRPSPEERETLAAYFWKYLHEPCKTLALPLDTVVHNIMCLDQFTSCLGEYKGSVFGVLHQDGLDGLAEKLYMDREVLVPKVFSDHRARQDMIEAVKAVERMYFNRIEGVEQITYSNPQSYYRDFCRVKYEANERGLSYALSRKTAIARAYEFVSAHHWIKVISYLTPCKYGSCGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X060</accession>
    <name>F9X060_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Integral membrane protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_33861</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X060"/>
    <dbReference type="STRING" id="336722.F9X060"/>
    <dbReference type="GeneID" id="13402922"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33861"/>
    <dbReference type="eggNOG" id="ENOG502S47U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064532_0_0_1"/>
    <dbReference type="InParanoid" id="F9X060"/>
    <dbReference type="OMA" id="YSIHVMA"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32738" checksum="CCBDEC48FBE8895B" modified="2011-10-19" version="1">MRFSAFIPVVFCTAAFILTVLCLFAGSKPSFMPGYDLLTFNASRIGHEVFNTSESSDNQCPRSFFDEVSNDIESRVQDRLTSIAQDLGLHDFYAVHIMSYCEGYYTPTAVPNATVHKSEIHQNVTGCANRTAMYNFDAKAIIQRELNETGHGEVFSRLNWSDDLDDGLYALRLTARAMFVLYCIAIGFIGIALISAVVSILFEGRLSALFNIIIDWLGFMTIGIASAVATAVAVKATDVINKYGDDIGISAKRGNKFLIITWVATGLMLLSSMVWCFACVKGRKNRGPSGKPGGRKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0C7</accession>
    <name>F9X0C7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_102643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856453.1">
        <property type="nucleotide sequence ID" value="XM_003856405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0C7"/>
    <dbReference type="GeneID" id="13399147"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102643"/>
    <dbReference type="HOGENOM" id="CLU_2401369_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0C7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="93" mass="10400" checksum="7F9EF9870E3DB3B9" modified="2011-10-19" version="1">MSHVVSLIGAGRFAELVARSMESQHIDIPSGQTMKEDVRRQRQHYHCLQEDKSLWNLACKHAVRQTASDGILDSGNDHISRPVTVSSIFDIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0M5</accession>
    <name>F9X0M5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856675.1">
        <property type="nucleotide sequence ID" value="XM_003856627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0M5"/>
    <dbReference type="STRING" id="336722.F9X0M5"/>
    <dbReference type="GeneID" id="13398081"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90030"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1766"/>
    <dbReference type="InParanoid" id="F9X0M5"/>
    <dbReference type="OrthoDB" id="3642847at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="746"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132238" checksum="AE70C8F51CB1A180" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1C9</accession>
    <name>F9X1C9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_78925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856589.1">
        <property type="nucleotide sequence ID" value="XM_003856541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1C9"/>
    <dbReference type="FunCoup" id="F9X1C9">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1C9"/>
    <dbReference type="GeneID" id="13395374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78925"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1565"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_3_0_1"/>
    <dbReference type="InParanoid" id="F9X1C9"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="11145" checksum="9749BD39DFC75B50" modified="2011-10-19" version="1">MLFFSFFKTLVNHEVTVELKNDISIRGTLKSVDQFLNIKLDNISVVDEVKFPHLSSVKNVFIRGSVVRYVHLPAAAVDTPLLEDATRREASQTAAKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1G5</accession>
    <name>F9X1G5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_31918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856915.1">
        <property type="nucleotide sequence ID" value="XM_003856867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1G5"/>
    <dbReference type="FunCoup" id="F9X1G5">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1G5"/>
    <dbReference type="GeneID" id="13398550"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31918"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="F9X1G5"/>
    <dbReference type="OMA" id="THCENRT"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP91891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="375" mass="40407" checksum="278D08665B953481" modified="2011-10-19" version="1">MIPCTVDVSTQSTDEPQNPAFVLRSVKNVAFEDRPIPQLRDAYDVRVHIRQTGICGSDVHYWQRGRIGDFVLKSPIILGHESAGIVAEVGTAVKNVKVGDRVAIEPGVPCRRCDHCRSGAYNLCADTVFAATPPWDGTLAKYYIVASDYVYPIPDHMTMEEGALVEPTAVAVQICKVADLKAGQTVLVMGCGPIGVMCQAVAKAYGAKKVVGIDVVQSRLDFAKTFGADYVYLPPKAEHGADPIQHSEKIAELIKENFELGEGPDAVLECTGAEACIQTGVFVARKGGTYVQAGMGKENVTFPITTACIRGLIIKGSIRYTAGCYPAAVDLVASGKIDVKRLITNRYKFEQAEEAFELVKAAHPDVFKVIIAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1M0</accession>
    <name>F9X1M0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856825.1">
        <property type="nucleotide sequence ID" value="XM_003856777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1M0"/>
    <dbReference type="STRING" id="336722.F9X1M0"/>
    <dbReference type="GeneID" id="13398383"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90276"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2076"/>
    <dbReference type="eggNOG" id="ENOG502RM44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="InParanoid" id="F9X1M0"/>
    <dbReference type="OMA" id="AGAKWRI"/>
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            <end position="205"/>
        </location>
    </feature>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RYYT">
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="494" mass="53235" checksum="2BC6ACE6C9F6083B" modified="2011-10-19" version="1">MSDDEFLEELHSATIVEARPVTVARSPITPLSGGFNFSNQGNIDDSCSVRSVSIYRSSSYRKMGDEGDQVSSEPPRSASAAKRLSATSSLEKHDLTARLTRNVSSGISRRIQALNEFNSREPSPVYTGQASPLTPETSPNAFLHQDSKDRSLPRRMLSKRRLSRQNAGSHTPPSPMEGAPVWNVQHDPVTNSNSVSVTARIVRPEQVPDENSALQQSDLSFAPRDSASYQSLPELPQAINTGIAQSATSTPPLSPAATTHSGEYRTLHSASGRFSRRRKTASSEDAGAVGRHSRNTSSAGTLNEDNAAPSIKEGNMASRFFKRVSTLGGPKSRKSVAPSVTSSMSGQGTTISERAEADTSDTPPGVVVGDLNVQFPDSLLWKRRIVSIDDHGALSFSPTQGSTRTNSHVARQSIASSVDTPIMTPGGGIAAKRFPLADFKSPTTPDLERQELPHSVVLEFPDGTTLQLACEDAMTQRQVLHLLRSYWKSWGAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X201</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="F9X201"/>
    <dbReference type="GeneID" id="13403749"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107818"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.50"/>
    <dbReference type="eggNOG" id="ENOG502S3A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="PTAYDDM"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="454" mass="49722" checksum="28372E478E39FF0F" modified="2011-10-19" version="1">MSTYFTLPSFARAKKHQDELEKSNPQEPVLKEEDEKFLERHLSIDESAGAATNAATSAPKPKKEKEKTLDLPSQEEAEAATRSWNAQNTSSGGTDTGDHKRTWASYIPAALVPSKGDSSKQAEEKQSSEGETGQKQTWAMYASQYVPSSATTLPSLPAMPAIPALSSWYRSKDKDATPELVYKEDGTVDEAATKEKQEKEVSVLLDNLNMSSINNRVFALSGETHKIYERFALVLKDTIEGGPTAYEDMEKLMKDAGPTLEKQFQSMPPFVQTLVKSLPAKMGLGLAPEFLATLSGDKPDDHLKAQGATASASTVSTDEKEKKKKKRKIPGLKKLVSQQGAVATMLRNTVSFITTRFPFLASTTNVVMSLSVFILMFVFWYCHKRGKEARLARTNESLDGGGKVEGEVDDAEDDDDVEAESTDDEISTAQEKAGEVASEAPVDKETEKETEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A9</accession>
    <name>F9X2A9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_68285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854914.1">
        <property type="nucleotide sequence ID" value="XM_003854866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A9"/>
    <dbReference type="FunCoup" id="F9X2A9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2A9"/>
    <dbReference type="GeneID" id="13403520"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68285"/>
    <dbReference type="eggNOG" id="ENOG502SIYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_3_0_1"/>
    <dbReference type="InParanoid" id="F9X2A9"/>
    <dbReference type="OMA" id="EIQTHAQ"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="534" mass="60017" checksum="0306333471DD1E6F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2E2</accession>
    <name>F9X2E2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_99175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855014.1">
        <property type="nucleotide sequence ID" value="XM_003854966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2E2"/>
    <dbReference type="STRING" id="336722.F9X2E2"/>
    <dbReference type="GeneID" id="13399805"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99175"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.723"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="InParanoid" id="F9X2E2"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53237" checksum="EDDA370F7EB58A1E" modified="2011-10-19" version="1">MSYFSQPTTTSPKVRRIRDLINRQASLKANKNDSNSSFYRLTTQSSSGYKLPMQIDHKPKLASQPSLIEELETKTRFPITIGTSPRSASLAKCDWQQQSPLFQLPQELRRLIFEFATSSHDDPNHNSISGGRVAAQPGRFKKQRVSTSLLRTCRRAWLEANALPLRNFEHRFWFCSVYSDAGQEWTKLSPADEDARLWKLLTTFTPNNRRNFEHLRLFASMWWLENKAVEYLPILLGVSGACPRVLTITVRHTDLWLVEEGRGIDVREEWLQRLLNAPSLERLQEIRLEVEALDDTPRQAILGSRAGVVELAVEKYRAVRTEARLTESGNLRQFELRNIREEIRKSGVEDLDIRLAKVWPKGFHLDYRSWTLVWKAADASTILGTPMLSKHREDAWIKRAMEQHRHDGEHGAAKHTRAAMMCLREWQDERSLLKLGRETIKAGYLSGAKRQVSLRGSLSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2N4</accession>
    <name>F9X2N4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_67799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854745.1">
        <property type="nucleotide sequence ID" value="XM_003854697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2N4"/>
    <dbReference type="STRING" id="336722.F9X2N4"/>
    <dbReference type="GeneID" id="13395930"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67799"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.126"/>
    <dbReference type="eggNOG" id="ENOG502RXCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037449_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2N4"/>
    <dbReference type="OMA" id="QSICIAD"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391250" evidence="1">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="28336" checksum="280467ADD704653B" modified="2011-10-19" version="1">MKTSILTLASVLSAAAVPQTYQQQTDDCEHPPAPSLCDKYTTALLKDNTAANQQTVLTLIVNTAIIGNYSSNPGSLVAVPGILAPGTGDYAGVDLSVYFTGALKSTNRGGKTGVSVNLLDGGGAAPLKKNKPADDTTSNQHRLVSHLYPYFAGLLGCSLFGNTTDPYPGPTSMYELHKFMALDEKQIGWFINNVGLSAASFGVTEEDVTTVGKALESTFGMRCSPPAKGPQSKAPELQAICIEPTCPLSTQPVCGQYDPVIEPVAAGGKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X345</accession>
    <name>F9X345_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_37498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855435.1">
        <property type="nucleotide sequence ID" value="XM_003855387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X345"/>
    <dbReference type="STRING" id="336722.F9X345"/>
    <dbReference type="GeneID" id="13399846"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37498"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="InParanoid" id="F9X345"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043494">
        <property type="term" value="C:CLRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="391"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="762" mass="86927" checksum="B1C6649AC61437C7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X366</accession>
    <name>F9X366_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_68962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855337.1">
        <property type="nucleotide sequence ID" value="XM_003855289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X366"/>
    <dbReference type="GeneID" id="13400082"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68962"/>
    <dbReference type="eggNOG" id="ENOG502QU1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_0_1"/>
    <dbReference type="InParanoid" id="F9X366"/>
    <dbReference type="OMA" id="DERHECY"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="505" mass="53705" checksum="45ECF42A4C922538" modified="2011-10-19" version="1">MSIADSFAGFQNSNWATCQANGQGCGLNFNAPQDPTYYADPKNCYQGSIPSYYIDVQEVSDVQAGLKFASDTGIPLVVKNSGHDYKGRSSAPNALSLWTHNIQTPIKLTRGFTPDGCSAPAGDAVTLPAGQGFKGVYEFAEANNITVLGGSSSTVGPVGGWINGGGHGALSNTLGLGVDNVLEIKTVLPSGEYVTANRCQNQDIFFALRGGGGSAFGVNMEMTTTAHPQVSHSFSSYIIFASLDLDSRRKLVKICAQNADKWATEGWGGYIAPGAKSTQTSGLILMTPKLTHAEAVISMKPLTNFAASLLNLPQKNGVHSEPSFYQAYQKYIVPNQEEVGLGIAVGSRLIPRASFQSASGQEAVTNAIIKASNFVTPILVTAPSSYQTDNTSSVTPAWYGPNGAVWHVLVGQCFANDATASEIQDAFSRAHNAADVLRAVAPDSGAYQNEADIFEPSPEDSFWGQENYQKLLGIKQQIDPNNVLTCWGCVGWDKSDARYSCYPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3C5</accession>
    <name>F9X3C5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854750.1">
        <property type="nucleotide sequence ID" value="XM_003854702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3C5"/>
    <dbReference type="GeneID" id="13403705"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90420"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.140"/>
    <dbReference type="eggNOG" id="ENOG502SXDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151421_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3C5"/>
    <dbReference type="OMA" id="YEEPDNG"/>
    <dbReference type="OrthoDB" id="4175349at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391100" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13582" checksum="C95DC25064D35E3A" modified="2011-10-19" version="1">MKSTIVFELAALAAVALCNPSGKDFTQLELPGWDAGDRLFPANVIEGYHDDYNNQTAKSWSHHVLERCRTFEDGTSTISYSAINSGTPKDRYWFGFCFRGGRTTATDYVLVDGVQDSIVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3T0</accession>
    <name>F9X3T0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855430.1">
        <property type="nucleotide sequence ID" value="XM_003855382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3T0"/>
    <dbReference type="FunCoup" id="F9X3T0">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="GeneID" id="13400977"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68707"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.826"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3T0"/>
    <dbReference type="OMA" id="MIGFGRP"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="343" mass="36933" checksum="1FDC532C0A61C726" modified="2011-10-19" version="1">MSPREDDWLFKPIRIGRSELSSRIVMGPLGSTLADENNVLDDSAREYYGKRACIPGTLIIGEATFVSPQASGTTEPRAGIYTEEQINSWKRIVDSVHGAGSFIYLQLWALGRSADPEIKARDGTGDVVSSSAVAQEGGPVPRALEEEEIWTYISDYAEAARVAVEVAGFDGVELHGGNNSLLDQFTQDAVNQRTDGWGGSIEKRSRFGVEVTAAVCAAIGSDRVGYRISPFSTYQSMGMKDAVPQFCDLLAGLKALGIAYVHLVESRIAGRVDVEAGESLDPFIEQWADYGPIVLAGGFSPESAATAVNTQYKDKDVLIAFGRAFVTNPDLVQKIKDGTPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4W4</accession>
    <name>F9X4W4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855250.1">
        <property type="nucleotide sequence ID" value="XM_003855202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4W4"/>
    <dbReference type="GeneID" id="13400495"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91254"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1197"/>
    <dbReference type="eggNOG" id="ENOG502R9DP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1908337_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4W4"/>
    <dbReference type="OrthoDB" id="3640708at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="15093" checksum="E042097B0486E921" modified="2011-10-19" version="1">MNAVEMSARLSRPDCPSAPQWRPTRTPSPSDLEGIQLFDFVRRHFCAGLSTLDNLLRYLELCGASDCQRRKSGIDSLLGNLRTLEEWLVKFLASELSWQSESVRVKAALMSTRNELRQYSWKVARVLHLLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X608</accession>
    <name>F9X608_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_103551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854639.1">
        <property type="nucleotide sequence ID" value="XM_003854591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X608"/>
    <dbReference type="STRING" id="336722.F9X608"/>
    <dbReference type="GeneID" id="13403991"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103551"/>
    <dbReference type="eggNOG" id="ENOG502S59M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150769_0_0_1"/>
    <dbReference type="InParanoid" id="F9X608"/>
    <dbReference type="OMA" id="NYHEENT"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="144" mass="16446" checksum="418D21528682B5C7" modified="2011-10-19" version="1" fragment="single">MSGAYRVELATSNRAGCAVKYCQDNNLKIKKGELRQGVTVQFKEHTTWKWRHWGCVTPSVIHNWKITSGGDMELVDGYDELPAPLQEKVERAFEQGHVDDDDWTGDVEMNRYDPQKPNQGMRMTKAMKKAKGGDSDDDEEEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X687</accession>
    <name>F9X687_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muconate cycloisomerase I, MLE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MLE</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_99485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853757.1">
        <property type="nucleotide sequence ID" value="XM_003853709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X687"/>
    <dbReference type="STRING" id="336722.F9X687"/>
    <dbReference type="GeneID" id="13395689"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99485"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.352"/>
    <dbReference type="eggNOG" id="ENOG502QVHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052062_0_0_1"/>
    <dbReference type="InParanoid" id="F9X687"/>
    <dbReference type="OMA" id="DTSEGWM"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="385" mass="41832" checksum="2DAF54BECFA7D8F6" modified="2011-10-19" version="1">MEFIVGTFNHPSLFLLQFHPPTASSPGTLNFIKEHAAIGGHSWLSLSKDKKYLYCTAWTSKPSIAAYRIASSGWDVQFINAKHVKALSGYVCSNETHVFSAGGPSGEVFKLEADGAIGDLVQEMDFITGQGENQSEKRGAVAHGDFGGLRHGAHSVDLSPDGKALYIADIGRNCIWTYKVLHSKRAINDPPLELGSKHISPRSHDGPRHTWPHPSGKVLYSLQEHSSMVDVFAVADDGVTLEHKQGGKLLPEGKDCKEFWADEVRYSTGPDAAKPKYLYASNRGLESGTLGYVAVFELDEQGLLKSEQAIDIWQTPTSGGLANAIEPAPWKKEFGDVEYLAMCDSEEGMVFVLSFDGKAVKEVARVNLGKTEDGKAIGAATPVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6G6</accession>
    <name>F9X6G6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_99715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854226.1">
        <property type="nucleotide sequence ID" value="XM_003854178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6G6"/>
    <dbReference type="FunCoup" id="F9X6G6">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6G6"/>
    <dbReference type="GeneID" id="13404403"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99715"/>
    <dbReference type="eggNOG" id="KOG0903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="InParanoid" id="F9X6G6"/>
    <dbReference type="OMA" id="TQDYVDV"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="660"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="954" mass="104783" checksum="4B52FBD6CFE12CA4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6S3</accession>
    <name>F9X6S3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_38013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854489.1">
        <property type="nucleotide sequence ID" value="XM_003854441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6S3"/>
    <dbReference type="STRING" id="336722.F9X6S3"/>
    <dbReference type="GeneID" id="13395676"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38013"/>
    <dbReference type="eggNOG" id="KOG0281">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
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            <begin position="277"/>
            <end position="322"/>
        </location>
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            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
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        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="761" mass="84087" checksum="53FE0DADF56BFACC" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8D3</accession>
    <name>F9X8D3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_18718</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853444.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X8D3"/>
    <dbReference type="GeneID" id="13397243"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18718"/>
    <dbReference type="eggNOG" id="ENOG502S5Q7">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096905_1_1_1"/>
    <dbReference type="InParanoid" id="F9X8D3"/>
    <dbReference type="OMA" id="RWQYLTQ"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="15286" checksum="4983177C10FA8A2C" modified="2011-10-19" version="1" fragment="single">SSIPDNRLGLSPSDVATLRQHQQLAHAQARSPAGSQASSQGRLLLDPGSLGLLARHFDAVMRAIQGRLEQLNTATERATTAQYDRAGNAIQMADAEIARFRAILKNIDELELEFEKIKRIRDIVRGFRARVEGLGRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8H3</accession>
    <name>F9X8H3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_104183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853022.1">
        <property type="nucleotide sequence ID" value="XM_003852974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8H3"/>
    <dbReference type="GeneID" id="13397343"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104183"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.486"/>
    <dbReference type="eggNOG" id="ENOG502S798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181109_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8H3"/>
    <dbReference type="OMA" id="VICKVCY"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
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        <property type="entry name" value="OS07G0114300 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
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        </location>
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            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="301" mass="34349" checksum="C25A58FFAF7B597A" modified="2011-10-19" version="1">MTSAAADDDEDDYLSMTFDAPPTTKVKESSLQRIARQKREAASRGNILPKAEREALDRAKLESALTTELDTANPSNKGALLMAKMGFKKGEALGKMEGARTRPIEVEMREGRGGIGLEGERKRKIRELAGEVEGGEKKVKLTAEEFRERNRVEVEERRVEGMVWGAMKVLEGIESGEDGVGEGKEKPLKSVNVLYRPLVKQRLERERERRMRYDMDQSLSRSRQYEEEEEDEKLAYGGEVEEDLEEEDTDLEAFEALDAKEKLEKLVGYLREEHHYCFWCKFKYEDAEMEGCPGLSEDEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
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            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79735" checksum="3E80441354D32C98" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X912</accession>
    <name>F9X912_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853376.1">
        <property type="nucleotide sequence ID" value="XM_003853328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X912"/>
    <dbReference type="GeneID" id="13397356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92633"/>
    <dbReference type="eggNOG" id="ENOG502SRZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373068_0_0_1"/>
    <dbReference type="InParanoid" id="F9X912"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84120" checksum="E38F3325204CF319" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9W4</accession>
    <name>F9X9W4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_108919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852798.1">
        <property type="nucleotide sequence ID" value="XM_003852750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9W4"/>
    <dbReference type="STRING" id="336722.F9X9W4"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108919"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.17"/>
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    <dbReference type="HOGENOM" id="CLU_018823_0_0_1"/>
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    <dbReference type="OMA" id="EMMSKQV"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0031965">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="15">
        <location>
            <begin position="469"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="125"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="154"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="193"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="693" mass="68247" checksum="020F3E9ED27DEE1C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9X2</accession>
    <name>F9X9X2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853601.1">
        <property type="nucleotide sequence ID" value="XM_003853553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9X2"/>
    <dbReference type="STRING" id="336722.F9X9X2"/>
    <dbReference type="GeneID" id="13400873"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108921"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.25"/>
    <dbReference type="eggNOG" id="ENOG502SERQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038857_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9X2"/>
    <dbReference type="OMA" id="YQRIPGF"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="422" mass="45796" checksum="E2AF5A287B50D49A" modified="2011-10-19" version="1">MAGVHGQVLGHLVRRGVSAAQEHFTSANDAYVQQLQQDATLYDTKADADVNWEVRSYEMIPIIITGFITLLVVAAIRYSIGEVMAALTMIESPSHMAIISDKPPAYADSPDAPLEKEPLMPSEAEADVEVMLVHSKPITTSKISTTMAHLYKIDGFRGKFRGARVSVMYHLLHSVVSNFLITVFDAGLVGNSLIYIFVSLGLARVHMAWTHAMIATDSPVSFWRSMPARKQCKAILLPTLAVALAEQATIIFPIIVAFAVGLPDMQSDHVVKAAQDGEGCQMGLLALRLLAVPATLIFVAVAVLLPATVTLTRIEAALLPEDRNTIVPFDREALVGDLDLTARGSSKALFVEAWRSFDSTSRWRLIKLYVKMVAIELSVVFVAAHVMVAEMYIIGGEKIALLAKSMSAQAKLAGIEAQEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA16</accession>
    <name>F9XA16_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate/L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_71420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853311.1">
        <property type="nucleotide sequence ID" value="XM_003853263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA16"/>
    <dbReference type="STRING" id="336722.F9XA16"/>
    <dbReference type="GeneID" id="13399979"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71420"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.646"/>
    <dbReference type="eggNOG" id="ENOG502QRW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_2_0_1"/>
    <dbReference type="InParanoid" id="F9XA16"/>
    <dbReference type="OMA" id="TNTEPAM"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="38769" checksum="424B00F4F1556123" modified="2011-10-19" version="1">MAEESASSPKVYVAPKDARKYVEAVLKGNGVPSENASIVARCLVAADLRGVDTHGVNRIPSYVARIRQGVLDAKAQPVLHETTPVVAQVDGMNAFGFVAAHMGMKKAIDMAQVYGIGMVSVKHSNHFGMSAWLVQQAIDAGMMSLVFTNSSPALPAWGGMTKLMGVSPIACGAPGGNEKPFILDMAPSVAARGKIYKAKRRGEKIPKEWALDANGRPTDDPALALDGVMLPMGGPKGSALAIMMDVFSGVLSGSAFAGHVTNPYDPSRPADVGHFLIAIKPDLFMPLEDFRARMDYLYKRVIDSDKMEGVDRIYFPGEIEQITEETRQQGGIPYVESEIAALNDEADRVGTAHIRIMQENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA63</accession>
    <name>F9XA63_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852985.1">
        <property type="nucleotide sequence ID" value="XM_003852937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA63"/>
    <dbReference type="STRING" id="336722.F9XA63"/>
    <dbReference type="GeneID" id="13397306"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92551"/>
    <dbReference type="eggNOG" id="ENOG502SYK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507359_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA63"/>
    <dbReference type="OrthoDB" id="3647587at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="132"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="537" mass="60024" checksum="C72ECACE6F599978" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAN3</accession>
    <name>F9XAN3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_42373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852766.1">
        <property type="nucleotide sequence ID" value="XM_003852718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAN3"/>
    <dbReference type="STRING" id="336722.F9XAN3"/>
    <dbReference type="GeneID" id="13393829"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42373"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.72"/>
    <dbReference type="eggNOG" id="ENOG502S7RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113002_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAN3"/>
    <dbReference type="OMA" id="DFAAMIW"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="14558" checksum="874BCA9BB63B763C" modified="2011-10-19" version="1">MQQPTPPEETANLLARLSQRPGVQGTLILSRDTGAIVRSSGLITNEDGETEAARPTSSDQVNGDGEVKKKGTRNAEDVARLVWRFVQSAGTMIEELNGDSDEAKLLRIRTKKNELVIVPDAKFLLVVIHDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAR2</accession>
    <name>F9XAR2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852751.1">
        <property type="nucleotide sequence ID" value="XM_003852703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAR2"/>
    <dbReference type="GeneID" id="13393844"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104364"/>
    <dbReference type="HOGENOM" id="CLU_2110860_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAR2"/>
    <dbReference type="OrthoDB" id="1722345at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="12593" checksum="84F559405015DC97" modified="2011-10-19" version="1">MNSEEFSLPRLLNQAGFLQIAANKGDVEMTRWLVKKGAKVNSMPSKECCCWDVNGTAVAYAVAAARVEVISLLLELGADPMLKDERGRTARQLNAIYGQQRTRERIDALLGPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB21</accession>
    <name>F9XB21_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_109582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852550.1">
        <property type="nucleotide sequence ID" value="XM_003852502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB21"/>
    <dbReference type="GeneID" id="13396872"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109582"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.536"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_1_1"/>
    <dbReference type="InParanoid" id="F9XB21"/>
    <dbReference type="OMA" id="AWYNMST"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395581" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="44279" checksum="1B50091B5FAE369F" modified="2011-10-19" version="1">MFAVRAILCILSALSTCTAVPLASIQHEHNHHGIQHPRKSISSPVKVTQEHAFVPPAPGQQRGPCPALNALANHAYISRDGIVSLLEAVNGVTTVFDMGIDLATLLAVMAVVWAGDALSPNPSFSIGGIDVRVTDAVGGLIGTTGPAQGLAKAHDILEADASPTRNDLYLTGDAATMNLTRFEKLYSLVPTDRAFTMDDMADFAVIRFRESIEENKYFYYGPFTGLVARSASFCFVGRLLANHSDGHAGGTLTHGILKSFYAVTGDDPSNFTYKRGWERIPENWYGGSGGYGVAEINLDIISMAVRHPVLASIGGNTGTVNSFTGVDLSNPATGLANIPSLLKSNNLMCFALELVKGAIPSTANSLFATLAGPLTKLFDAVDAPLLSLACPAWRSVTEGGQSFLKRLQATYPGAKGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBD3</accession>
    <name>F9XBD3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_41746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852261.1">
        <property type="nucleotide sequence ID" value="XM_003852213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBD3"/>
    <dbReference type="STRING" id="336722.F9XBD3"/>
    <dbReference type="GeneID" id="13396870"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41746"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="F9XBD3"/>
    <dbReference type="OMA" id="WSYAKGM"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="32412" checksum="5B0F167B832314EF" modified="2011-10-19" version="1">MQSWNRLVRFVAVEDHLEHIGEPIDPDLDIGDALSTTTPAKVRITTSSSPLDLNLTFTSTILTIASLLPPMSRSEIGTIRCIGLNYHLHAKEMSLPIPTYPSLFFKPATALGCPSAPLIIPHQATDEQADYEAELAFVIGKTCRNVCKADAERYILGYMCSNDVTARKWQFAGSNSQWGYGKGFDGFAPMGPCLVSSRKIKLSDLGMVEVRTEVNGEVLQNGRGDDMIFGVAEVVEHLSRGTTLEAGTVVMLGTPPGIGVSRVPPRWLKDGDEVRIVGSHGLGSLVNRVVYEKGPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM3</accession>
    <name>F9XBM3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RCC1 domain and calcium binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_109427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852134.1">
        <property type="nucleotide sequence ID" value="XM_003852086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBM3"/>
    <dbReference type="STRING" id="336722.F9XBM3"/>
    <dbReference type="GeneID" id="13397010"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109427"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.251"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009681_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBM3"/>
    <dbReference type="OMA" id="WHCLNCP"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF8">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="883" mass="98662" checksum="3D3C37D67AA3E3A4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC18</accession>
    <name>F9XC18_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_104628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852317.1">
        <property type="nucleotide sequence ID" value="XM_003852269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC18"/>
    <dbReference type="FunCoup" id="F9XC18">
        <property type="interactions" value="1470"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC18"/>
    <dbReference type="GeneID" id="13396818"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104628"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.654"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="F9XC18"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="681" mass="73984" checksum="6468909C2B4211FE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC84</accession>
    <name>F9XC84_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MgMLG2</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_42064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852187.1">
        <property type="nucleotide sequence ID" value="XM_003852139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC84"/>
    <dbReference type="STRING" id="336722.F9XC84"/>
    <dbReference type="GeneID" id="13396959"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42064"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.364"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_0_1_1"/>
    <dbReference type="InParanoid" id="F9XC84"/>
    <dbReference type="OMA" id="FKNAYWL"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395452" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="41886" checksum="95BF5DEEA9306561" modified="2011-10-19" version="1">MHVTTLLHSLSVLAGSAFAAYKLEDDYFDGSFFDKFEFWDLDDPTHGFVKYGNRTTSEELGLLNSTDGNIKMFVDSNNVTPKGRPSVRIKTSKVYNQALIVIDMDHMPGGICGTWPAFWTLGPAWPTHGEIDIMEGVHDQPGNKMTLHSGPLCTNLTNTGGTGKVTLTECLSGDGTQNSGCQIATNDSITYGAGFNANKGGVYATEWLADSISMWFFPRGHCPTDALGDCPDPSSWGPPLARFITGDECDISAAFKDQQLLFDTTFCGDWAGQPTVWGNSTCAKKTDTCEEYVRENPKDFADAYWSVNALKVYTDGDKKSDAPANPGPAAQSTNTVYQPAPPTSAPKAQGGGSSTGTNGAASFAKREDEQREYARHLGAHKRRGGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCG6</accession>
    <name>F9XCG6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgLAC4</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_86272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852361.1">
        <property type="nucleotide sequence ID" value="XM_003852313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCG6"/>
    <dbReference type="STRING" id="336722.F9XCG6"/>
    <dbReference type="GeneID" id="13394138"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86272"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCG6"/>
    <dbReference type="OMA" id="WASAMLD"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF1">
        <property type="entry name" value="LACTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="6">
        <location>
            <begin position="747"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115617" checksum="28E554801A71FA69" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCH6</accession>
    <name>F9XCH6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_72608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCH6"/>
    <dbReference type="GeneID" id="13394143"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72608"/>
    <dbReference type="eggNOG" id="ENOG502QQ7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCH6"/>
    <dbReference type="OMA" id="CDGHEPC"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="586" mass="65112" checksum="790FAB11CF82F456" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCN4</accession>
    <name>F9XCN4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109733</name>
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    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109733"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.102"/>
    <dbReference type="eggNOG" id="ENOG502QSQ0">
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    <dbReference type="InParanoid" id="F9XCN4"/>
    <dbReference type="OMA" id="EWMYKYV"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:maintenance of protein location in cell cortex"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
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            <end position="756"/>
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    </feature>
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            <end position="773"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1170"/>
        </location>
    </feature>
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        <location>
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            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1348" mass="147290" checksum="831CC29C9F2CB4A9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCR6</accession>
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        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_100423</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
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    <dbReference type="EMBL" id="CM001201">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="153"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="304"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="663"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="797" mass="87143" checksum="94CE88F7B54FFAB8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCR9</accession>
    <name>F9XCR9_ZYMTI</name>
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            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LIP1</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_72841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
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    <dbReference type="ESTHER" id="zymti-f9xcr9">
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            <end position="440"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="490" mass="54059" checksum="ED7E7DB3986DD7D7" modified="2011-10-19" version="1">MLPLVLSLAGLTTAQLFVGGSSPIVDTGYARFQGRRDEVTKTDNYLGIPYAHAPRFDHARIFDDQLSGVQQATQYGDVCPQHLLNPSILAPDVGEVSLPFAQKATRQSEDCLSINVQRPKDQSLKDLPVVVWIHGGGFETSLPGVFYQGASIVQRSLSMGKPVLFTSINYRLHHFGFTASREFEKEGLLNLGLEDQRVALRWIQKNIKAFGGDPSKVTIMGESAGSWSVTAHMLVNDGDNEGLFRGAVGISGGPLRVDGPERQQALFNDMVSYVGCDGASDKIACLRQAPYDKIYAHANTVNNFFGFRSLASAWTLRPDGKFLTDSPDRLVAQGKIANVPIMYGDMENEGTLFSLINQLNITTTELVKDYFKTYWWPKVTETQLDRLMDLYPADIDNFPADGLPQYKRLSALIGDYSFEAQRRSLLAKVTANKWNYYTKFSIPLSVAGDTVVGKLLAGLKLTTIPVLASFHASDVLQVSPGPRRLCEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81110"/>
    <dbReference type="HOGENOM" id="CLU_2361362_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCW8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="96" mass="9200" checksum="8AB507A0384DE46C" modified="2011-10-19" version="1">MDAAGAGFFDGKALATPCEGGGLDGGVEEGSDAVFGFDAGNDRVAGAFVAALVGGNAFGAVAAAAVGFTATFFCPPPPTGPSAAMAPMTPLPYPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE55</accession>
    <name>F9XE55_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">MYCGRDRAFT_44328</name>
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    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGP86313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE55"/>
    <dbReference type="GeneID" id="13393767"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44328"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_5_1_1"/>
    <dbReference type="InParanoid" id="F9XE55"/>
    <dbReference type="OMA" id="KNAWWWL"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="78007" checksum="C992EA05EDB5145D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEF7</accession>
    <name>F9XEF7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MYCGRDRAFT_86368</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851916.1"/>
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        <property type="interactions" value="835"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86368"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="F9XEF7"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990753">
        <property type="term" value="C:equatorial cell cortex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="233"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="480"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="574"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="704"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGP86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="839" mass="92233" checksum="3BF53877F32F2354" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEG3</accession>
    <name>F9XEG3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_43643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851361.1">
        <property type="nucleotide sequence ID" value="XM_003851313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEG3"/>
    <dbReference type="STRING" id="336722.F9XEG3"/>
    <dbReference type="GeneID" id="13393737"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43643"/>
    <dbReference type="eggNOG" id="ENOG502SJ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013260_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEG3"/>
    <dbReference type="OMA" id="VVCQHEG"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="684" mass="77404" checksum="6296A291428EC1A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEG5</accession>
    <name>F9XEG5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851702.1">
        <property type="nucleotide sequence ID" value="XM_003851654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEG5"/>
    <dbReference type="STRING" id="336722.F9XEG5"/>
    <dbReference type="GeneID" id="13401855"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43539"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_3_0_1"/>
    <dbReference type="InParanoid" id="F9XEG5"/>
    <dbReference type="OMA" id="PHFPEMA"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="167"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="361" mass="40433" checksum="CD846FE5977C1427" modified="2011-10-19" version="1">MKVSKIIVYPIKALRAVELEEAEVTKEGFPNDRRFMILHVTKDKDGNTEYKNVHVAHYPESVLFFPSLNTAAGTMTVTYKPPQGESKTIDIPLRPDISDLSTINIEMHKSPTKAYQMPQEYSEWFSTCYAKEVILVYLGEHLRPVLMSSTQPPQTSNNSATGWLSSITSTAAAYLPTSISNSLPSPGITFADCAPYLVASETSMDDLQTRLESEKMDIIKFRPNIIVSGADEAWEEDFWSELTIGNATKIECVHNCGRCKSVNIDYETGQPGTTEQGSMLKKMQKDRRVDAGVKYSPIFGRYSFLGEGCEGEVVRVGDEVVVSRRNEERTKFGEFDLFSICPMLHASSRSMLWIQSLTVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEH9</accession>
    <name>F9XEH9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_110020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851652.1">
        <property type="nucleotide sequence ID" value="XM_003851604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEH9"/>
    <dbReference type="GeneID" id="13401863"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110020"/>
    <dbReference type="HOGENOM" id="CLU_1836709_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEH9"/>
    <dbReference type="OrthoDB" id="5397846at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="15602" checksum="D6576130EBBB8636" modified="2011-10-19" version="1">MPDSATIAASTAGPIRRMQHSSLYNRVARPVVAPLSLIEDYDEAYASANPGELPPRLYERVTRRERQLTYKPGQKITFMTLPPEIHLKLPRSLRVPGIFTEAISFFFANTPVSMAFRSNCSRAFCAATCAFQSKRCDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEJ5</accession>
    <name>F9XEJ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_44322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
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        <property type="protein sequence ID" value="EGP86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEJ5"/>
    <dbReference type="STRING" id="336722.F9XEJ5"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44322"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="InParanoid" id="F9XEJ5"/>
    <dbReference type="OMA" id="MNVIMEK"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="413" mass="45794" checksum="421F8A8FBD7D36DC" modified="2011-10-19" version="1">MLDLLSIAADHCLKSEDSFFLADFGRVVKQFELWNTHLPAVRPFYAVKCNPDPNLLGLLAQLGSGFDCASIAEMHLALATGVRSKDIIFANPCKAPSALAFAAREGLTTTTFDNHSELEKIKILMPNARLLLRIYANDPTALVPLGDKFGATRCSVASLLHKAHALGLNVVGISFHVGSGASDLDSLRAAIESARYAWDLAESLHMPMEILDIGGGFQSSSKSFISMATAVKEAIARARFPAHTKLIAEPGRFFAKDAYTLFTQVISLRENDTHEQPCRTSCSWQHMLYQNDGVYKSFMNRIIEKEEFHPILVPVSRTNNVLEEGTHTYSIWGPTCDSTDLISRRAAFPCRVQVGDWLMYENMGAYTLSTATRFNGFSDERRILYVNNLERDDEKQTWNGNSELSGQRLGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEK8</accession>
    <name>F9XEK8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_94183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851667.1">
        <property type="nucleotide sequence ID" value="XM_003851619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEK8"/>
    <dbReference type="STRING" id="336722.F9XEK8"/>
    <dbReference type="GeneID" id="13401878"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94183"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.701"/>
    <dbReference type="eggNOG" id="ENOG502S8BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032994_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEK8"/>
    <dbReference type="OMA" id="RYAFVHW"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="627" mass="68059" checksum="8FBD5F4959EBBEED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XER2</accession>
    <name>F9XER2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850608.1">
        <property type="nucleotide sequence ID" value="XM_003850560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XER2"/>
    <dbReference type="GeneID" id="13401099"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110086"/>
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</entry>
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                <person name="Hane J.K."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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                <person name="Hane J.K."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850925.1">
        <property type="nucleotide sequence ID" value="XM_003850877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFG0"/>
    <dbReference type="GeneID" id="13397663"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94833"/>
    <dbReference type="HOGENOM" id="CLU_1742017_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFG0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="150" mass="16219" checksum="B531E8316D7E7964" modified="2011-10-19" version="1">MAPMFNAIENGRASELDTEYDSSASRVFLTGAPRKQVGRLFDQAKRIDSTQWDHGLGLPAPDACSQERASSESRIDWQSGGSSLRGGKAKASYKQISSLSSNASEGDQEANDSDMDVQDPHTPDDIANDDKTSTKTRMATPISISQLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFL6</accession>
    <name>F9XFL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_73913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850675.1">
        <property type="nucleotide sequence ID" value="XM_003850627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFL6"/>
    <dbReference type="FunCoup" id="F9XFL6">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFL6"/>
    <dbReference type="GeneID" id="13397928"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73913"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007606_1_2_1"/>
    <dbReference type="InParanoid" id="F9XFL6"/>
    <dbReference type="OMA" id="IQIKRTH"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55481" checksum="ADC41B0243318DE7" modified="2011-10-19" version="1" fragment="single">MYTSTTTSLRRNANGATSSVYSGNKIRHLKKEDGIPLWRKDIQYDFLKLVFFDQTKCFTKFSDGTNGHTFADIYIDAMAKSSKCSKILKEKLLQDQDGAISMAMVCLLVNVGRMNTTLNFFPEMRAQLRTYHSIPALQAHQDPNAYKQLQDAPRLKSILKGATEDEPQPATMDEIKAASRPRTNPVNLIFVMSQYAPKISELHFPPPRDFFDLVMRSSLGSVSRAKAFLWLIWWYLESDFTKEDAERNPFGPGQFDPADEGADALPVKVPTLESLTEEQAAEENVDTEEEKHFGEVKRKERIAILASEPSPAMTALKRARKEKGLTTGHGVHASDDEGSEVGSYHRGMMPASVGKMSTLHLETASDYTRSPSPAGSRGFQPINNKPVSDMRIDNMLNSDDVAPDPSSPQATISGFARDHIPTPSYQAQKRHRGVTQHQSAVMTHRKQQIDYTLDRRIRKAHVAFRNTRESESAIVRAWKRIRALPLDYDSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHB9</accession>
    <name>F9XHB9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_105609</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850220.1">
        <property type="nucleotide sequence ID" value="XM_003850172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHB9"/>
    <dbReference type="FunCoup" id="F9XHB9">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHB9"/>
    <dbReference type="GeneID" id="13394573"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105609"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.712"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_1_1"/>
    <dbReference type="InParanoid" id="F9XHB9"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="51407" checksum="B1082B9EC1795519" modified="2011-10-19" version="1">MPTAARDIPERNGMDADSLARTVSASFSNSYSTSPTLNYHSPNASYGGAPKASYKQLKPFHTQDVKVLLLENINLTGQDILKKQGYQVEALKSALPEDQLIEKIQDVQVIGIRSKTQLSANVLKHAKNLIVIGCFCIGTNQVDLKYAAEQGIAVFNSPFSNSRSVAELMIGEIIALARQIGDRSNEMHQGVWNKVSAGCWEVRGKTLGIIGYGHVGAQLSVLAESMGMKVIYYDVVNMMGLGTARLVPTMDALLEASDFVTLHVPELPETKNLIGAKELAKMKNGSYLLNASRGTVVDIEALIGAMKSGKIAGAALDVYPNEPGGNGPHFNEQLNSWGKELCAQKNLILTPHIGGSTEEAQAAIGSEVAEALVNYVNFGTTNGAVNMPEVALRSLTINESNHLRVIYIHKNVPGVLRRVNEILGDHNVDKQMTDSRGDVAYLMADISNVNVSEIKTLYQNLEDLGSRIRTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHT8</accession>
    <name>F9XHT8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849874.1">
        <property type="nucleotide sequence ID" value="XM_003849826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHT8"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94887"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.23"/>
    <dbReference type="HOGENOM" id="CLU_1176229_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHT8"/>
    <dbReference type="OMA" id="GDWGGNG"/>
    <dbReference type="OrthoDB" id="10571864at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="22671" checksum="7BA7B00F0751502D" modified="2011-10-19" version="1">MLPFGGGFGGGMGAFGGGGGMNPLGGGMNQPGGGGGLEAQLAQIDHQIDRIWNRGMERGYMTMATYQRYMRLCNEGDQLEQYIMMQQQQQPQQQQQGPGLATMLGFGRGQGQGGAAGAAAGGGQPGQGQGGPAGGAAGGFAAGGAAPPTRAQCAATMRNLVRGGGGGGQFDFGAGAGAQQQPQPPAPGGGAGGAGGQGSGRGGGESRRGGGGGGGGGGGGGEYDPNVLGDIFAPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIL2</accession>
    <name>F9XIL2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase complex beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_117734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIL2"/>
    <dbReference type="FunCoup" id="F9XIL2">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIL2"/>
    <dbReference type="GeneID" id="13394389"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_117734"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.551"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XIL2"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="419"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="532" mass="56480" checksum="8D948368B443121E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIT4</accession>
    <name>F9XIT4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_75597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849694.1">
        <property type="nucleotide sequence ID" value="XM_003849646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIT4"/>
    <dbReference type="FunCoup" id="F9XIT4">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIT4"/>
    <dbReference type="GeneID" id="13399107"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75597"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.337"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIT4"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="8">
        <location>
            <begin position="492"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="722" mass="79105" checksum="BB22A93C6F3E904D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIY4</accession>
    <name>F9XIY4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_21444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849668.1">
        <property type="nucleotide sequence ID" value="XM_003849620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIY4"/>
    <dbReference type="STRING" id="336722.F9XIY4"/>
    <dbReference type="GeneID" id="13402465"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21444"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_3_3_1"/>
    <dbReference type="InParanoid" id="F9XIY4"/>
    <dbReference type="OMA" id="LRMFVSH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
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    <sequence length="643" mass="73387" checksum="D79C2CBCE077B7A5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="333" mass="39086" checksum="8429C2289D7916ED" modified="2011-10-19" version="1">MEDFPFHQNHMRGTESGFELTENEFGRPTLVRIDSDWSPLLSDTADFLTTAAGRVLRQRIEKRRPLLPEDLGGVDLSVLSKSTLESIYRDHFTATEKLQDCKEMNNMLKAFDTQTTEKYGILRPYIHPKTLCCVTDQERVNWASAYDDVADTDIFSAFSKTPKTRSSEDDEHTAKTWIAIVKSPQVNWVNNPRWKDFPWHLWAFAIVGGPTAHGKYLFIYDCDSGPLLERHQTVKLKDLHGSIVKWYKLIIKRWQIKKVFMGNIHDDFISDTMEYKQYSDTSIEVDENHCIGHTMRWVHKMSWIKDKPFEEEDLKEPRWESFVEMEYLSKNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKQ3</accession>
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            <fullName evidence="6">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
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    </gene>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Schouten H.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="625" mass="71819" checksum="3831347BBEA27797" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL81</accession>
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        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.328"/>
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    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL81"/>
    <dbReference type="OMA" id="MCFEMHG"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KH-I_MUG60_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="275"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="571"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="658"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119625" checksum="E20FE8BA6E67FC99" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XML6</accession>
    <name>F9XML6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="9">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CYP-29</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_76681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848297.1">
        <property type="nucleotide sequence ID" value="XM_003848249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XML6"/>
    <dbReference type="STRING" id="336722.F9XML6"/>
    <dbReference type="GeneID" id="13396110"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76681"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.86"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="F9XML6"/>
    <dbReference type="OMA" id="VPEHYEH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="521" mass="58784" checksum="0E5D1DA2798FB3B1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMW1</accession>
    <name>F9XMW1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC/SMC6 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_219702</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848646.1">
        <property type="nucleotide sequence ID" value="XM_003848598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMW1"/>
    <dbReference type="FunCoup" id="F9XMW1">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMW1"/>
    <dbReference type="GeneID" id="13396129"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_219702"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XMW1"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="122"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="289"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="447"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="739"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP83622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124868" checksum="6E333D36E92DBF33" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN71</accession>
    <name>F9XN71_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane fusion mating protein FIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848589.1">
        <property type="nucleotide sequence ID" value="XM_003848541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN71"/>
    <dbReference type="FunCoup" id="F9XN71">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="13396158"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111281"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.307"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068733_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN71"/>
    <dbReference type="OMA" id="YFGICVN"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28971" checksum="178BEBB71FBA25CE" modified="2011-10-19" version="1">MPNIRLAVGIQRLIPFLGYHHVLMILIALAIILLSLLLAGCSSSSPLIPGIFLISFYYEMYTPRYDPTQVNPGVTAAITNIVGGASLEVRVGYFGLCIQPDDGSFLCSNNATLLAQQISIDADPLNLIWVANTFKNSVVFPYLLIVAIILAFGTFLLLATFPGWHEEHDARTGSDIDIKPFPSRPVSQVALALIFISSIFVLVSVLWQHTASVAAAQVAQDFGNGSVKSGVGTAAMVLGWFGFALLIIVTVGLLVMILSIHLLDKLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNE1</accession>
    <name>F9XNE1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848205.1">
        <property type="nucleotide sequence ID" value="XM_003848157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNE1"/>
    <dbReference type="STRING" id="336722.F9XNE1"/>
    <dbReference type="GeneID" id="13401788"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96942"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_0_1"/>
    <dbReference type="InParanoid" id="F9XNE1"/>
    <dbReference type="OMA" id="WFPGVAD"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF3">
        <property type="entry name" value="PEROXISOMAL D3,D2-ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="273" mass="30658" checksum="B19A71A867767BD1" modified="2011-10-19" version="1">MFFVADSASNDQLTQFQFNRPKQLNSFGGSMISDTISALRELDRHPDTTFTVLTGEGRFFAAGADVTSVTKTPTSFKNEGEKKIFWAERFAVGMELVRSIIDHKKVVVLAMNGHGVGAGAAWFQGSSDLFYAAEGTWLQVTFSQLGLIPENGSAVNWAQHMGVHRANDWLMFGGKAPVEELKEMGLVNKIFPKENFHAEVHAYLKEMLRERDGNSLMEMKRLQNKSTRDARILGLFEAWQALSEKFVAGEPQKRMGAKMQELADKRKNRESKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNJ5</accession>
    <name>F9XNJ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MgBGL2</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_64142</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847905.1">
        <property type="nucleotide sequence ID" value="XM_003847857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNJ5"/>
    <dbReference type="STRING" id="336722.F9XNJ5"/>
    <dbReference type="GeneID" id="13396078"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64142"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="InParanoid" id="F9XNJ5"/>
    <dbReference type="OMA" id="HTTYLPG"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395583" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="789"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="866" mass="93675" checksum="77D32B6330DF9DCE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP41</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003847959.1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97171"/>
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    <dbReference type="HOGENOM" id="CLU_006454_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122970" checksum="6B1BC6A2D017DCE6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPD6</accession>
    <name>F9XPD6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_77172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848247.1">
        <property type="nucleotide sequence ID" value="XM_003848199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPD6"/>
    <dbReference type="GeneID" id="13401491"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77172"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.19"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="F9XPD6"/>
    <dbReference type="OMA" id="MSDFYTT"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19144">
        <property type="entry name" value="AKR_AKR13A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="359" mass="39616" checksum="BFA856D545AE7506" modified="2011-10-19" version="1">MSASIQNLASKATGGAVGPTLPVRKLGKNGPTITALGYGTMGLSAFYGAPKPDAERFAVLDKAFDLGELFWDSADMYQDSEDLLGAWFKQNPGKREKIFLATKFANCSDAEGNRWVDSTPEYCRKACEKSLKRLGVESIDLYYAHRLDGKTPVELTVRELKKLKEEGKIKYIGLSECDSDSLRRACKVEHIDAVQIEYSPFSLDIESEQIGLLKTARELGVAIVAYSPIGRGMLGGQIRSPKDFEEGDFRTFAPRFSEENFPKNLELVGRITEIAKKKNCTASQLTLAWLMAQGDDIFPIPGTTNLSRLEENVNSLKVKLSKEEEQEIRKACENAVVSGARYPEAFAASCFASTPPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPJ1</accession>
    <name>F9XPJ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_77239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848213.1">
        <property type="nucleotide sequence ID" value="XM_003848165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPJ1"/>
    <dbReference type="STRING" id="336722.F9XPJ1"/>
    <dbReference type="MEROPS" id="C45.001"/>
    <dbReference type="GeneID" id="13401512"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77239"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.73"/>
    <dbReference type="InParanoid" id="F9XPJ1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="344" mass="38773" checksum="2F7D6CE5A5B935AF" modified="2011-10-19" version="1">MPKMLRIECSGTPYEIGLQHGQEARVQISRSIMFYADLFLKEAKLDWYQVQSLAMKFEPVIREKWPAYMEEMRGIADGTDLGVEDIIAINVRTEIAFGAFSDGCTALSWKTDEHSWLAQNWDWNEVQKKNLVFLSIEQPGKPRIKMITEAGLIGKIGLNDAGVGVCLNAIKAKGMDATRLPCHLGLRMVLESTSRADAVEKLEKFGISSACHMLIADENGGVGVEWSSTDVAKLEMNDARQVFHANHFLLQHDGVEDKKWLEDSSFRTSRIEELAEKVEGEPTYEKLYDIFCDEENFPGGICRKMEGRSQSASLFNIVMDLKARRADVTLGRPTEPEEKIILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPW9</accession>
    <name>F9XPW9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_101861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847783.1">
        <property type="nucleotide sequence ID" value="XM_003847735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPW9"/>
    <dbReference type="STRING" id="336722.F9XPW9"/>
    <dbReference type="GeneID" id="13401201"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101861"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025946_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPW9"/>
    <dbReference type="OMA" id="VTNLHML"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP82759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="489" mass="52113" checksum="B0203F0AA102417D" modified="2011-10-19" version="1">MLAEHFIASTGVPAKAPGPNVAKDAAIFLHEFQPLAAQRSIFKKSATPPNCLAVSESHIFAAQADKGVVHVYNRLKGNQEAIVPFTEKLASITLACDDSVLVLGTAEGRIFLWETCTGRQITTSQAHLQAVTALAVDASSNFLLSASKDSTVHVWSLPALLSFSTTSAVSPLRTFSSHRSEITSLTLGNGASNCNFVVSISKDKSCLVWDYHNNNLLRTYLLPGVPLCLALDPADRAAFVGYEDGTLQQLDLHTSSNGALDAIQNGSNPTEPVQPPASTRWKLPESTHGAALSLSISFDGSTAISGHQSGTILAWDVPRGSFVSTQTQLPLPGPVSNVQFLPVTGFAARDQRTTKINEIVKPKFGAFDSSDRDSVPGNYTLQVQFPTDIASTNATKQNNSFLDALTAPAFPLALLDEGLNELASWKKSPSTHANGAANLEALRRVQQKSLQKIVALSDENSILQKRGQQNSGASDATSEEESSSEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPZ7</accession>
    <name>F9XPZ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_51460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847767.1">
        <property type="nucleotide sequence ID" value="XM_003847719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPZ7"/>
    <dbReference type="GeneID" id="13401191"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51460"/>
    <dbReference type="eggNOG" id="ENOG502SYNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045816_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPZ7"/>
    <dbReference type="OMA" id="MGAWGYC"/>
    <dbReference type="OrthoDB" id="3648505at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="292" mass="32481" checksum="DA33F40ACA18A909" modified="2011-10-19" version="1">MGAWALTLFSCDYDLDLIKELSCLTGLPHLEAEAGKLASTASTAAQRQADHARLQESINPNSIATLPLPAPVSANDIHYSVYAKLCSDPEKIRQHLDSGILHQHMTRLSQEVTNANSYWRTDPYGPGYQLVMLGCCAMTLGAHLASAEMDMMRAHYRTVHFVRDAVTQIETALDPDEGYVNGIPWDFCTKAMYEGSKHSEEDQLFPGAGMMNCWAPDHGRSRDEMAQFRAMALSLEGYEHFFAADACGGCGKGESRNGGGPLQLCQRCKAVRYCCRGCQKRQWRFHRRYCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ48</accession>
    <name>F9XQ48_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_101876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847743.1">
        <property type="nucleotide sequence ID" value="XM_003847695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ48"/>
    <dbReference type="GeneID" id="13400803"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101876"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="InParanoid" id="F9XQ48"/>
    <dbReference type="OMA" id="MWTVRKR"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="525" mass="57530" checksum="899A703C9ED0AF13" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQD8</accession>
    <name>F9XQD8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847648.1">
        <property type="nucleotide sequence ID" value="XM_003847600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQD8"/>
    <dbReference type="GeneID" id="13401155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106556"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.321"/>
    <dbReference type="HOGENOM" id="CLU_2252186_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQD8"/>
    <dbReference type="OrthoDB" id="5410795at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="104" mass="11125" checksum="8238FCCEF56D4F81" modified="2011-10-19" version="1">MPFALQHPDAKAVSDHQTCTLNIPISISVQGPAKFPTYEIRLGDILGGLLKLDNLSSGILQEDATIVSVHASSTMPLQVVSCDHATKSPHRESLTQCSLEFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQV6</accession>
    <name>F9XQV6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847319.1">
        <property type="nucleotide sequence ID" value="XM_003847271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQV6"/>
    <dbReference type="STRING" id="336722.F9XQV6"/>
    <dbReference type="GeneID" id="13400128"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97646"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.36"/>
    <dbReference type="HOGENOM" id="CLU_054597_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQV6"/>
    <dbReference type="OrthoDB" id="3860121at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="141"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="402" mass="45128" checksum="E65B2EBA12AB2B64" modified="2011-10-19" version="1">MAERTVRFRAMVHGKLDMQTQDVNIQETFQWSQAGTLNNLLHRTRTVLFNGEDAIYRDVTKVKEVLRNAPGCRKPVFVDDPNVRKLVERYDISRVLKEKQEVVGNDKLFSVQDPSVGMSSTPVKELSLLDLMNQFDYPAEPSSAPLNVLDFAPATDEPTKTLHKMLIGEHTLLPKLWAAVMRNRTPKAKAMAGGRSPCRWATFAESGALSAPHVDIDGLGTYITIAQGEILFLWCDSMNDAETEQWQKQDLLNALENHDWNCTVMEAGQSVVFPAGTPHAVIRNPGDSPTLSFGGHFLHPQQLPRFASLCRQQLKNPSSAALNEDPESTVWVYLLLAAKHVLRARAAARKDWARIFGGNENVGQFFQVLKSIDARLAEASIKIEKPFEFRGKKRVLRRSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQZ9</accession>
    <name>F9XQZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847341.1">
        <property type="nucleotide sequence ID" value="XM_003847293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQZ9"/>
    <dbReference type="GeneID" id="13400320"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97685"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.77"/>
    <dbReference type="HOGENOM" id="CLU_874950_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQZ9"/>
    <dbReference type="OrthoDB" id="10310914at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35949" checksum="868E6286F5BC98C6" modified="2011-10-19" version="1">MDTTFSGSGSGQLLHKSPGKKSGHSIPMQEMARQRRREMINKQTNQSNHLPPRNHTHKLALVHIIIPVLIVLVGCIVLVGWRIDQNRLRFETSHDHPLIATLPATTHNFTGLDLDLRQIVSGIPVSNITQIHMYPFIWKETQRTIRQVEMYVTRFRGTCAASASRYNDPLREALEADALARATEGWDGRFLRDLDWVELPFLRSFLRSCWEGGRTMVAIEDAIKNSRRRFPGTIAEIEASFQTLAEAYKTTAELFRALQEGPLEFAAKVAQEGDEGYVDDFRHVLGRCVARVESAVEEVNDGGKAWRIEAETDTDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRW5</accession>
    <name>F9XRW5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847012.1">
        <property type="nucleotide sequence ID" value="XM_003846964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRW5"/>
    <dbReference type="GeneID" id="13399257"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97959"/>
    <dbReference type="HOGENOM" id="CLU_1636756_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRW5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="18063" checksum="E6840DC4E6B16F7E" modified="2011-10-19" version="1">MLEQLDLDTPATPLHSEAIVSRKRKRQEQDQAQDVVAEGDFDSDSGSAMDAEIGRRGRSPLLDRSSTLWELVGSHHDGIESDRPNPPSDSERADQYSPIQIDVFDDNPLDGGSEHASNNTSYDTHRLPERKAKDPPALGTRALKRRRDEAPKRPSPEVRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRX7</accession>
    <name>F9XRX7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847020.1">
        <property type="nucleotide sequence ID" value="XM_003846972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRX7"/>
    <dbReference type="GeneID" id="13399415"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97970"/>
    <dbReference type="HOGENOM" id="CLU_2063339_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRX7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="13128" checksum="3B23263A4A455D71" modified="2011-10-19" version="1">MSAPLLMVIGEFLPGLFGMGFVTLLKGFVLVFDGGDVFVCLQPRLQLSKLCLEDGAARRMLAWRDVGCGVVSYLSYHDIGAGSVRLNHGKMKGWRKMEGGSKTKQTFDRGDERHGYEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS54</accession>
    <name>F9XS54_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846960.1">
        <property type="nucleotide sequence ID" value="XM_003846912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS54"/>
    <dbReference type="GeneID" id="13396749"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106703"/>
    <dbReference type="HOGENOM" id="CLU_2905891_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS54"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="7327" checksum="3979DCB718BA6819" modified="2011-10-19" version="1">MQSSKLTSFPSFCFGVFSLAFSLHNLFSGLRAMRLWYFDRPLDCAWRRVHVGELGMRIARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS55</accession>
    <name>F9XS55_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846931.1">
        <property type="nucleotide sequence ID" value="XM_003846883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS55"/>
    <dbReference type="GeneID" id="13396719"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98044"/>
    <dbReference type="HOGENOM" id="CLU_1526389_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS55"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="176" mass="19074" checksum="C7754FBAD3E55BC7" modified="2011-10-19" version="1">MASVAIQSIRAHLAKYLDKIPSKTAMIQFFRGQELDLLPLIPCLIPPTLHNQIAAYSGATTDAPGYTLCKKCTRLHLDRGHSDCTWCAKVSWYRMAVYSAAICATTVCGMRIMSLGLAMWRETSELVSKTADIPGAAEAASSSDGTVVLVSKCGPTTSDGEVFLDWTTWSITPRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWG2</accession>
    <name>F9WWG2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_83691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856219.1">
        <property type="nucleotide sequence ID" value="XM_003856171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWG2"/>
    <dbReference type="GeneID" id="13403002"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83691"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWG2"/>
    <dbReference type="OMA" id="GQFPMGD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="4">
        <location>
            <begin position="441"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="610" mass="68830" checksum="C61EB81600856E78" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWL2</accession>
    <name>F9WWL2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EXG3</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_83843</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856363.1">
        <property type="nucleotide sequence ID" value="XM_003856315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWL2"/>
    <dbReference type="STRING" id="336722.F9WWL2"/>
    <dbReference type="GeneID" id="13402880"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83843"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_4_2_1"/>
    <dbReference type="InParanoid" id="F9WWL2"/>
    <dbReference type="OMA" id="WYWTWKT"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="251"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP91339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="616" mass="68313" checksum="A8A71730786F9730" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX02</accession>
    <name>F9WX02_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_33390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857054.1">
        <property type="nucleotide sequence ID" value="XM_003857006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX02"/>
    <dbReference type="FunCoup" id="F9WX02">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WX02"/>
    <dbReference type="GeneID" id="13395411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33390"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_2_1_1"/>
    <dbReference type="InParanoid" id="F9WX02"/>
    <dbReference type="OMA" id="HWSKFQC"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22789" checksum="489E4C4142094E50" modified="2011-10-19" version="1">MLQQTSYNSTTSFLRPGSKFRGTQQSDRQVYDVQVEIKDVDMAESFLCGYLRIQGLTDDHPTLTTFFEGEIIGPKYLFKTDHPSWGSSEKVDMQHWARFPAWRPLAKSAKSANFSLNKFEQREHLFMRWKEYFLVPDHKVKTITGASFEGFYYICFNQCSGTVSGIYFHAKSEKYQQLELRHVEDKGCMPAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXB9</accession>
    <name>F9WXB9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_33309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857810.1">
        <property type="nucleotide sequence ID" value="XM_003857762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXB9"/>
    <dbReference type="STRING" id="336722.F9WXB9"/>
    <dbReference type="GeneID" id="13403803"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33309"/>
    <dbReference type="eggNOG" id="ENOG502SABV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019095_0_2_1"/>
    <dbReference type="InParanoid" id="F9WXB9"/>
    <dbReference type="OMA" id="DKMCKDT"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395191" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="260" mass="28875" checksum="271A60FE23B5D0AA" modified="2011-10-19" version="1" fragment="single">MFTQQLLALTALAAFTSAHSWVEEYQVISDNGSYTGPLGYTRGFVPRTDPTFDGFSMMWLQPNASARNDDGTTRTRIDSTDYVCAPQQRKPTYTSGYPKLQVSPGDYVAMKYLENGHVSLPWNITGKPESGGTVFIFGTTKPSENERLADVMQWNKEGTSGNKNGFLLAAQNYDDGRCHQINCGSISQQRQMLQPNHAPGQMTSTLESWCESDVQIPEKAAIGTLTIYWVWQFPTAPNVDCNQPAGKDEYYTSCADFDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXL9</accession>
    <name>F9WXL9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_106883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855996.1">
        <property type="nucleotide sequence ID" value="XM_003855948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXL9"/>
    <dbReference type="STRING" id="336722.F9WXL9"/>
    <dbReference type="GeneID" id="13403226"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106883"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026654_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXL9"/>
    <dbReference type="OMA" id="PPPYHDW"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38787" checksum="A31D7C64017F4783" modified="2011-10-19" version="1">MDDDEYAPPPGPPPSRVPQYQQYAPPPGPPPSHTTNNSHPSSLREEPSPPPYDPWLGPDDSLRPPPSFAAVQPASTKSPTGNATFDDAARAHLWSRYNPLFQPATHSPQAIHRILSSDLRLTVPPNTTEVTQYQPAIGRTYIRTTPFLTDTILLSDLPVYSPNAQSPLMTATPHTIYFEVAVKHIGDRYNPANKTESGLGIGFVAPPYPAWRLPGWNRGSLGIHSDDGRRYVDNSYGGVPFVNAFAAGDIVGVGMTFAPPKHGDRAGMRAEVFFTRNGTREGGWDLYEERDQAAEEGNVEGLEGEHDLLAAVGLFSEAVLMSCPRVDHLWHVQIYPRSHENDSFNVGGVFESCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXT2</accession>
    <name>F9WXT2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_32778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857541.1">
        <property type="nucleotide sequence ID" value="XM_003857493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXT2"/>
    <dbReference type="STRING" id="336722.F9WXT2"/>
    <dbReference type="GeneID" id="13403112"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32778"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_4_0_1"/>
    <dbReference type="InParanoid" id="F9WXT2"/>
    <dbReference type="OMA" id="ERWKESP"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="409" mass="45922" checksum="4C309669CA2CC93A" modified="2011-10-19" version="1" fragment="single">MSPSLRPTTAAIPIPVADERSWNELNPLERWKNSPPENEPARMSDIAHALATSPSPLERYKKRKTSSNGSKTSNARPQSVTSCETGRTSSLSASSAAFSNGSRRRRPMVPKALDRKPADDKKRIFQCTFCTDTFKSKYDWTRHEKSLHLSLEKWICAPLGPVITDQETGMKKCVYCDLHNPSSDHIESHNHRQCEDKGLDARTFYRKDHLRQHLRLMHACEMVPSTESWKSMAQNINSRCGFCAQRFSVWQERVDHLTAHFKAGVRMVAWKGCRGLDPAVAAQVTNAMPPYLIGMEAVTPNPFSATNRASWRLPEEVNGCQEGAIDSTAVPTSGTDSKSTCWEILTIRLGQFAKEQADQGLPITDDLLQRQARRILYDGDDDAWNQTSADNPEWLALFKKAHGLDLIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXV3</accession>
    <name>F9WXV3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_19317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857531.1">
        <property type="nucleotide sequence ID" value="XM_003857483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXV3"/>
    <dbReference type="GeneID" id="13394371"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19317"/>
    <dbReference type="eggNOG" id="ENOG502SV1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073382_2_0_1"/>
    <dbReference type="InParanoid" id="F9WXV3"/>
    <dbReference type="OMA" id="QCLGWVD"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12639" checksum="9B4BC227C949AA1A" modified="2011-10-19" version="1" fragment="single">PTWRTIQTSKTTHTDPRSALLYMNHSCNGHPLEYGLAGEIKVSRDRGVEPGEPLTFFYPSTEWKFDRSFDCLCGAGKGVCVGNVQGASAIDYKSLDRWFINEHIWQMARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY92</accession>
    <name>F9WY92_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_66791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856525.1">
        <property type="nucleotide sequence ID" value="XM_003856477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY92"/>
    <dbReference type="FunCoup" id="F9WY92">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY92"/>
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    </dbReference>
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        <property type="entry name" value="Putative pleiotropic regulator 1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="405"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="182"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="509"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="499"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
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        <source>
            <dbReference type="RuleBase" id="RU369036"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EGP91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="509" mass="55623" checksum="D0F095E0B68B0C59" modified="2011-10-19" version="1">MAEVLQASEQVAVAEIPTEVAEHASEAVRTSAKRTREVFAADFGHLSALSKAPQPAVAPDDPSPQDRAQKASVAARIRNEYAHVKELPAALAQKQANAAAGLAARRKKPKTDEQASDPQMAKMIEDASVSKQQTPATNGISTALTRINGTANAKLPPNANGPTPQRNTPSSSLVRRDTVRQQKPEWHPPWKLFRVISGHLGWVRALAMEPGNQWFASGAGDRTIKIWDLATGTLKLTLTGHISSVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTMSLHPTLDVLCTGGRDGVVRVWDMRTRSNIHVLSGHKGTVSSIVTQATDPQVISGSLDSTVRMYDLAAGKTMGVLTHHKKGVRSLVTHPTEFTFASASPGQIKQWLCPKGDFMMNFEGHNSVINTLSVNEDNVLFSGGDNGSVSFWDWKTGHRFQHEDSVAQPGSLDAEAGIMTSTFDHTGLRLITGEADKTIKVWRQDENATEETHPLDWRPTLGRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYD0</accession>
    <name>F9WYD0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_67108</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856626.1">
        <property type="nucleotide sequence ID" value="XM_003856578.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9WYD0">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYD0"/>
    <dbReference type="GeneID" id="13398839"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67108"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1659"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYD0"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular mRNA localization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
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        <property type="entry name" value="Coatomer_bsu_C"/>
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    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
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        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="681"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="822"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="962" mass="106683" checksum="04E926EF40BC24E9" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </subcellularLocation>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="224" mass="25230" checksum="62B0502997137912" modified="2011-10-19" version="1">MSQAHDLHRALLRPAIIHTLRAAGFHSTKPSVLDTLVNLAERHLLLLASTTAQHAWSSHNDPVPTITDLRMALSDCGVLIPYSDPSEEAWKERMRKPLSEDTKDVREFTRWYDSPQYREIKRVAGIIPDDRDDFFTALKKKLSKAADDTRLQGTALGRPNEFKEVVVEGGPVQHVRDWKPKLEERSVNVQAQNTAERSKEPQDGLDTVDDIAKDSAMEEVEAAS</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="342"/>
        </location>
    </feature>
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        <location>
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            <end position="497"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="378"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="561"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857733.1">
        <property type="nucleotide sequence ID" value="XM_003857685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYP1"/>
    <dbReference type="GeneID" id="13403845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51973"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="InParanoid" id="F9WYP1"/>
    <dbReference type="OMA" id="GWFKPHP"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="37"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="38968" checksum="35D4E80E0A10ACAC" modified="2011-10-19" version="1" fragment="single">MLNTIKMSASRRLSALSNQTRNSSSKTTMKEAIVSAGPKVTIRDVPVPTPGPYQVVTKVIYSGSNPKDWKRAEAAPDVSKAVNQGDDISGIVHEVGSNVSEFKPGDRVIAFHEMMKPGGSYAEYALSWAHTTIHLPSNISFQAGAAIPLAALTAAVGLFARLRLPPPWLPATKPIPLIIYGAASAVGAYAIQLASRANIHPLICVAGASAAHVESLIDRSKGDTIIDYRSGPDAIVQGFKDAARGTTIEYAFDAVSEKGSYQAICQVLNPSTGKITLVLPGKKYADIPEGIEKSVTTVGSVHGFPDDLRDFGSVAMRYIGKGLEEGWFKPQPHEVVEGGLGGVEEGLRRLKEGKARAVKYCFEIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZE1</accession>
    <name>F9WZE1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_107355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856419.1">
        <property type="nucleotide sequence ID" value="XM_003856371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZE1"/>
    <dbReference type="STRING" id="336722.F9WZE1"/>
    <dbReference type="GeneID" id="13399179"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107355"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZE1"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53598" checksum="F6D5005925CDBC8C" modified="2011-10-19" version="1">MLIRRGKEEGWLNWSLEATHQWARSSGIKFTNATPAIVPGRGIGLLADHDLSSPPSSQMPLEVLAIAEDLVLSLETIKQHALFDRDFREVLESLGQFGTTPRGAILTFLLFNATISCPHLSEKVGVHSAFTDYVKTLPCEHLPTFWTPDELSLLAGTTLAPAISAKLKSLRREYDLLCSSTGTRWYKIVQQHISFDDWLQVDAFFRSRALDFHGNCMIPGMDLASHAAGEDTNTFYDRQDGKYILWLMKGKEVKKGQEITITYGDEMLFSYGFIDQDMESAETLFLSLAIPDEDPSKISKIKFADCAPGFKIIDTSDQPAVGSETHESRSGDIDWTGDFIWLLCVGHEDGFQLQLARTVDGAEEVEATFQGETLSDARDLRRKLSQSSLWDVYRLRAVVILQQRVYDQLQVLYGTQEGIESLPRGDTTNIGEPQYELATKLRRLEFGLLETAYEDFERQKLELAESAVVKDYLAGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZG0</accession>
    <name>F9WZG0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855851.1">
        <property type="nucleotide sequence ID" value="XM_003855803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZG0"/>
    <dbReference type="GeneID" id="13403358"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88628"/>
    <dbReference type="HOGENOM" id="CLU_674754_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZG0"/>
    <dbReference type="OrthoDB" id="10515368at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="46403" checksum="7323659ED15ADA01" modified="2011-10-19" version="1">MSDKFYVVMDNQTQHEILHGEAKFIQGLHAISLEPELRISALPSFAPSSDPSIERSFTQSFKSVNLVRFRLRFSWFRTSPTQCNLRELPYHVLDTNNCRMNVVVGLSTVAAISKGGPEEIRKAWPPIRKTKVLEPTLVWELPKPARETGTTWKLDHDKNITQATIKWINEEKWDQQRQDAWGLLKGKHMRLLYEAAENGTIGTLDQTTGGYYLSVMQQFIQGLDGVFFNNQLAPYCKFRFYEDIGEELEAYAELIEGNFVMIKVKLSAMENVSDIRNAVLHELCHAVQLLLGCDSAHGCRTCLTEAEFIGPIEHPECFLDLSMHVENLATTLFGEQVDLGRKAAIDSFDDVINDAGETYPHHATHHFTMMHWRETLQKTNAPGRVVWGVQPCSGNELRRANAPLKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZM8</accession>
    <name>F9WZM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_33900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855938.1">
        <property type="nucleotide sequence ID" value="XM_003855890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZM8"/>
    <dbReference type="GeneID" id="13403269"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33900"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.248"/>
    <dbReference type="eggNOG" id="ENOG502SESG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102601_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZM8"/>
    <dbReference type="OMA" id="GCVTHYT"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14509" checksum="05FAB3FA895257B8" modified="2011-10-19" version="1">MASTDPQNRKPEPSRLLLLSQVHLHAPGSKIRFLGCVHSYRISTGTLVIQEKYAAAPSAVPTVLASIDNVLEDVDHEMLQTGAWVNVIGYIRAGKGKEDVPRVEVLMIWPAGAVKVDDYHSAARSYQAAMSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZU7</accession>
    <name>F9WZU7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-crosslinking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_65433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856059.1">
        <property type="nucleotide sequence ID" value="XM_003856011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZU7"/>
    <dbReference type="STRING" id="336722.F9WZU7"/>
    <dbReference type="GeneID" id="13403159"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65433"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.493"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="InParanoid" id="F9WZU7"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29700" checksum="A2F2C0CEC01EFA1A" modified="2011-10-19" version="1">MVKALSFKGDKKPHKKRKRTNEDANEEDAPSSKQLIPADGPPEDDENWVSAESVEDIAGPVVIVLATEPVSCAAVDQLGKVFTSTVENMVENEPSTAEPHDVRQVWISQRIVGSENSFTFKGHHGKYLGCDKYGILSSTREAVSPEETFRCTVSDSKPGHFDIQTMRSTFLAADGDKSPPELRGDAEEAGETTAVRIRMQARFKPKHKVDKAEKVRAKISRKELEAEVGRRLDDDEVKKLKKSRREGDFHEVMLQVKVKGKHDKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZY1</accession>
    <name>F9WZY1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_65710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856160.1">
        <property type="nucleotide sequence ID" value="XM_003856112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZY1"/>
    <dbReference type="GeneID" id="13403064"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65710"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.705"/>
    <dbReference type="eggNOG" id="KOG4654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029861_1_1_1"/>
    <dbReference type="InParanoid" id="F9WZY1"/>
    <dbReference type="OMA" id="YEATHLN"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="620" mass="69622" checksum="44022EC126A1C47B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0I1</accession>
    <name>F9X0I1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_66917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856571.1">
        <property type="nucleotide sequence ID" value="XM_003856523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0I1"/>
    <dbReference type="FunCoup" id="F9X0I1">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0I1"/>
    <dbReference type="GeneID" id="13395280"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66917"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1536"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069447_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0I1"/>
    <dbReference type="OMA" id="DYIFREN"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="259" mass="28873" checksum="4246F9E54AC2D741" modified="2011-10-19" version="1">MSHTNTRLGGGAFNHGPSSNAEAEYDRLRDLARKEQGQHQHYAAEARRAYESGDGGRAHDMSTQSKNHAAKADQYNKQASEFIFRENNSMGKVAGDTIDLHGQFVEEAEEILEQRIKYAQSTGQSHLHVIVGKGNHSPGHIQKIKPRVEQVCRELGLQYRTEANEGRMYIDLQGGAVHQMPAYHYQQHEPQHSQYGKPHYETAYPMGNTPNYGNGGGYPGQQPMQYAGQTNYPGAPQQQMQVQEPSKKESSCCGLCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0V3</accession>
    <name>F9X0V3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EXG8</name>
        <name evidence="23" type="ORF">MYCGRDRAFT_107092</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857467.1">
        <property type="nucleotide sequence ID" value="XM_003857419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0V3"/>
    <dbReference type="STRING" id="336722.F9X0V3"/>
    <dbReference type="GeneID" id="13403038"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107092"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.763"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_0_2_1"/>
    <dbReference type="InParanoid" id="F9X0V3"/>
    <dbReference type="OMA" id="ANAKYYW"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP92443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="445" mass="44866" checksum="B40599A9B1CA4A82" modified="2011-10-19" version="1">MRFSSAIVVAGAASANAALQGFNYGAGLTTGAAKTQQDFETDFKRAQNLPGTSGWNAARLYTSIQTGSQNDPIAAIPAAIATNTKLLLGIWASAGQEAVTNELAAIDKAIQQYGSKFTDLVVGLSCGSEDLYRVTATGIKNKAGIGAGPDVLLSYIKQIKAKNWGFSIGHVDTWTAWTNSSNNEVIEAIDWLGYDGYPYFETDLSNSIDNAKSQFDQSFGATKGASMGKPVWMTESGWPVSGPTSGQAEASVDNAERYWQEVACMLIESDTPTFWYTLRDAEPSVPSPSFGIIGQDVNSDPLYDLSCSAKNSTSSSASSSATSAMASSAMASGTATATATEASTTASGSSSGESGSPGVAPLASASPSSGSSGSGSSGSGSSGSGSGSSGSSNSTSPSYMPGSPSAASPSSTGSMPAQYSTGAASSNGLSAIAAIAAIIGLVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1B6</accession>
    <name>F9X1B6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_66947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857106.1">
        <property type="nucleotide sequence ID" value="XM_003857058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1B6"/>
    <dbReference type="GeneID" id="13395367"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66947"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088665_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1B6"/>
    <dbReference type="OMA" id="SWRKKQT"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="247" mass="27631" checksum="6A664C6C87EF7F31" modified="2011-10-19" version="1">MSYNPSNAYSSASPAPPLPSYHSTPPPPPPKTSTPSSRGPPLPPTPGQQHQSSELDGGQNYHTQQPRISPIEPGWLPETLRDKSTSDLHRILSTPSLQSALLTNPSTAHPSIQQSVAPLQPLINTNLHLTSTLLDLERQLSHLRQHTQTRLLSLRALEQNHRTKISETETALQEFSPMALYQRLSASGQEQEALNRGLEESWLEEEGLASEREVGEFVRRVKEGRKVAFLRRERKGRWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A2</accession>
    <name>F9X2A2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854912.1">
        <property type="nucleotide sequence ID" value="XM_003854864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A2"/>
    <dbReference type="GeneID" id="13403525"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108025"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.508"/>
    <dbReference type="eggNOG" id="ENOG502SV8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374728_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2A2"/>
    <dbReference type="OMA" id="MELFVHP"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="87994" checksum="6A16442444D0E610" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J0</accession>
    <name>F9X2J0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PGM</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_54663</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855794.1">
        <property type="nucleotide sequence ID" value="XM_003855746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2J0"/>
    <dbReference type="FunCoup" id="F9X2J0">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2J0"/>
    <dbReference type="GeneID" id="13395892"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54663"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.78"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="InParanoid" id="F9X2J0"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="296"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP90770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="554" mass="60764" checksum="686DAFD2B0D5E6E5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2M8</accession>
    <name>F9X2M8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_90404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855775.1">
        <property type="nucleotide sequence ID" value="XM_003855727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2M8"/>
    <dbReference type="GeneID" id="13403715"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90404"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921982_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2M8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33292" checksum="94ED00263F899D99" modified="2011-10-19" version="1">MADIPGNYSDKAVHEKLSSAEKDGQWSISEQELYDAVFAENAEHQLGVWEAAKKQPVMEAYDMFLNGKFVALPAFQKRFGDRLPNGKYSIDTKWQSGLNQAGQCGAFIGLFLAGPITNWIGYRWNLIFGLILMNATIFAESASKTVANCADISPINVVVLILLGVCATVPQNHSTSLAQAALVFIGTLVFAGGIGPVSWTIIAETSSVRLRPLTTGVGRAAYYVAEIPLIYVNARLINPTGWNLAGKCGYVWGATALVCWVIAYLFLPEMKHRSYRELDILFEREVPARQFKYTVIDVKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2R1</accession>
    <name>F9X2R1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_99032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854834.1">
        <property type="nucleotide sequence ID" value="XM_003854786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2R1"/>
    <dbReference type="GeneID" id="13403612"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99032"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.330"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_2_0_1"/>
    <dbReference type="InParanoid" id="F9X2R1"/>
    <dbReference type="OMA" id="IFWQNCT"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="577" mass="64429" checksum="90C8941CFE15E436" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2R9</accession>
    <name>F9X2R9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_107945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855669.1">
        <property type="nucleotide sequence ID" value="XM_003855621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2R9"/>
    <dbReference type="FunCoup" id="F9X2R9">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2R9"/>
    <dbReference type="GeneID" id="13396024"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107945"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2R9"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="167"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="320" mass="37063" checksum="9C09ADD07E56B53B" modified="2011-10-19" version="1">MLARKELERARLEKLDKKRKREEDEAEQTRAREEKKRRLAEESKRYREEEAEEEERARRKRLGLPELEKKKDGENGTALNEGEQDLSEEDLLTRLQELNEPRFLFGETHVQRLRRYRKLTEKAIAPKLTTGPIPTTLELVPEKDMKVPETVPKDPEAHKFLLRQLASYFDMLLSEWQSALARRSKEVKESSTGKVAFNSFLAARDNLKPLFKKLESDNFPSVLLAPVLEIVHLAQTKRYVSANDAYLRVSIGKAAWPIGVTMVGIHERSAREKLHETEKTGNQAHILSDEVTRKMLQGIKRCLSFAQTRWPPEDIAQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2W5</accession>
    <name>F9X2W5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_68361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855553.1">
        <property type="nucleotide sequence ID" value="XM_003855505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2W5"/>
    <dbReference type="FunCoup" id="F9X2W5">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2W5"/>
    <dbReference type="GeneID" id="13403493"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68361"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="F9X2W5"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000004">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="13">
        <location>
            <begin position="257"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="39446" checksum="B84B6D27B3B428CC" modified="2011-10-19" version="1">MSTATPSDDLHVVLKTAHETPTTQTFHVGTRRSMLARVQADEVVKSLRAAWPEHNFEIHAMSTTGDNNQKTALHKFNEKALWTQELEVLLESKELDLIVHSLKDMPTQLPAELDLTCVTKREDPRDALVLKPDLVGKVRGLSDLPEGAIVGTSSLRRTAQLKRHYPQLQFKDVRGNIGTRLAKLDDPNGDYSAICIAVAGLERLGMSDRINVFLSKENGGMLHAVGQGALGIETRKDDTRTIELLSRIGDDRTMRQAFAERQLMRTLEGGCSVPIGVETQWKKEETASDELIMRAIVVSLDGQDAAEIETRRIVSNIEQANELGFDVARMLVEKGADRILKEVQLNRGIIENQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2X5</accession>
    <name>F9X2X5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_12562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855549.1">
        <property type="nucleotide sequence ID" value="XM_003855501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2X5"/>
    <dbReference type="GeneID" id="13403489"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_12562"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="InParanoid" id="F9X2X5"/>
    <dbReference type="OMA" id="ILPISMY"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="476" mass="52655" checksum="7F28498CEF4B3F26" modified="2011-10-19" version="1" fragment="single">QRTIVSFPTGDPDNPYNWSRGKKTYVLLTCMVLVLNSTTGSALPSGATEQTKEYFHITNDSLLVLPVSIYLIGYVLGPLLFAPLSETFGRRPLILGTFILFTAFHLGCALAPTFSGLIIMRLLTGIGSSTPVSVIGGVYADIYSTPKARGRAVTMFMAATTWGPLLGPIVSGYVAPAMGWRWTYWVGLMIAGATWPFVVFLPETYGPVLLQRRAARLRRETGDAGIVAPIEMQRQTWQEFCTVVLTRPVRMFLNEWIVLFSCLYLSVAYAIFYIFFQAYPIIFQGVYGMSAGEQGLTFLPIGVGAMLAGGIYLYWERFLEKARERDPMPEWAGVEEYVRLPIACLGAPLFAISLFWLGWTARPSIHWIVPTLSALPFGIGFLLIFMALINYMVDAYEIYAASAMGIASCTRSIFGVVVPFAARPMYDALGIGWGCTLLGCVSLVMGVVPFAFLRYGGVIRSRSRWCGELKRAKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X390</accession>
    <name>F9X390_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_91133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855323.1">
        <property type="nucleotide sequence ID" value="XM_003855275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X390"/>
    <dbReference type="STRING" id="336722.F9X390"/>
    <dbReference type="GeneID" id="13400719"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91133"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1045"/>
    <dbReference type="eggNOG" id="ENOG502S5F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441605_0_0_1"/>
    <dbReference type="InParanoid" id="F9X390"/>
    <dbReference type="OMA" id="DEWVPHC"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="619" mass="70018" checksum="A37B5647D3954E26" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q9</accession>
    <name>F9X3Q9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_68445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855524.1">
        <property type="nucleotide sequence ID" value="XM_003855476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Q9"/>
    <dbReference type="FunCoup" id="F9X3Q9">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3Q9"/>
    <dbReference type="GeneID" id="13399607"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68445"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.637"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X3Q9"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="395" mass="43601" checksum="7B25CD6C4B82CE88" modified="2011-10-19" version="1">MPTELEELVEFLHHGNTEIRQIAAENLVGYSTAQPSLFKYNDSEPVRDLKLLIKDYPPIAKNALTILINISEDTAVVEALISDDAFMEALLKRISDAKEPHADLQCMLLANLSKSDKIPSLLTLSRPIPKPLSTSPLAIDQLLDCFVKGASNSYNPNATYDYLSYLFADMAKHESGRKHFLTPRPESGAAQTTSTSTSTTTSESSEQVLPLSKLTVFTTHPTSPIRRRGVASTIKNICFDIPSHPTLLSPSEEGGLDLLPYILLPLMGSEEYSDEDTDALPEACQLLPPDKEREGQNDIIVIHLETLLLLTTTAEGRKELRGKGVYAVIRALHEQVEEEGVREGCDRLVQVLMRGEEGDEGYEAPTMPSGMKALEEAKKVTEVEEDQEEQIVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3R7</accession>
    <name>F9X3R7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855520.1">
        <property type="nucleotide sequence ID" value="XM_003855472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3R7"/>
    <dbReference type="GeneID" id="13399611"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90803"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.645"/>
    <dbReference type="HOGENOM" id="CLU_1448802_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3R7"/>
    <dbReference type="OrthoDB" id="3650791at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="20825" checksum="19D9E7669030AA77" modified="2011-10-19" version="1">MKSKASIDLVDSFQHKLDGVAPLPRGVDNIKLASLPTMRKAVRKLKKMDWSGQTYEDFAKKTEKLNPDVEFTKDLMDDGCSPSWTSMSSTPSTDSGHSPDEALCFESSRTKSPALKGEALNMKLPTLPSKRLPSNEPYQLGCEFQTYEGFAKKTEKWNPEENFTKESMDEAFRSAISVTIAHAGHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3T4</accession>
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        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_36895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855057.1">
        <property type="nucleotide sequence ID" value="XM_003855009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3T4"/>
    <dbReference type="STRING" id="336722.F9X3T4"/>
    <dbReference type="GeneID" id="13399848"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36895"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3T4"/>
    <dbReference type="OMA" id="HGKGFGH"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="425"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="701" mass="74486" checksum="558AD40C2BC20665" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4L6</accession>
    <name>F9X4L6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_108218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP90371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855347.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X4L6"/>
    <dbReference type="GeneID" id="13400942"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108218"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.898"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
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    <dbReference type="HOGENOM" id="CLU_279941_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4L6"/>
    <dbReference type="OMA" id="ATGCHSA"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="MLST8"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
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        <property type="match status" value="2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="298"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
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        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
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            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123046" checksum="8EFF7313557C3EA9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4L8"/>
    <dbReference type="STRING" id="336722.F9X4L8"/>
    <dbReference type="GeneID" id="13400034"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_55724"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.902"/>
    <dbReference type="eggNOG" id="ENOG502S0QA">
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    </dbReference>
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    <dbReference type="OrthoDB" id="16547at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="238" mass="26822" checksum="720AA99E529513DC" modified="2011-10-19" version="1">MDAANLIERGDTPDALGPGSPKKDFETSDLYKNVYDYVKEYMSRYDCSHDFNHILRVEGLAKHILAEEQKANPEKKLHKQAILLAALLHDVGDKKYIKPGENAEQMVSGVLARNGCPPRFVAKVSLIVENVSYTNETKRPQYVKAIVGAHPELAIVQDADRLDAIGAVGIGRVFAFGAVRDTGRGLQGSIDHFTDKLEKLESMMKTDTGKRLARQRTRRLREFRSWWEEENELVLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4N8</accession>
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        </recommendedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4N8"/>
    <dbReference type="STRING" id="336722.F9X4N8"/>
    <dbReference type="GeneID" id="13400931"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68847"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.925"/>
    <dbReference type="eggNOG" id="ENOG502SHWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_2_0_1"/>
    <dbReference type="InParanoid" id="F9X4N8"/>
    <dbReference type="OMA" id="PDNECYA"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="304" mass="34208" checksum="4DCF2DF6C76C872E" modified="2011-10-19" version="1">MSSGSKRIVFTGGSGKAGRHVIPELLKKGHQVLNLDLIPFPDPKAGVYTLKTDLTQSGQVFNALTSHYDMEGYELGRPEPPPDVVIHFAAYARNMLVPDNECFTANVASTYNVIEAACKLGVKKIIIASSETTYGVCFAEGDYDYHSFPLEEDYDCDPMDSYALSKLCGERTARTFARRYGVDIYALRIGNVIEPHEYATDFEAYVNKPMTRKRNAWSYIDARDLGQICTLSIEKSGLGFQVFNATNDTITTKIPTAQFLKENCPNVPVTREMGEWEAPLSNRKIREVLGFKDNHDWRQYYKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4Y1</accession>
    <name>F9X4Y1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_69157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003855192.1"/>
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    <dbReference type="STRING" id="336722.F9X4Y1"/>
    <dbReference type="GeneID" id="13400306"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1215"/>
    <dbReference type="eggNOG" id="ENOG502S0KS">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="40"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="36"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90216.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23662" checksum="37D5E1DF9D7B4ED0" modified="2011-10-19" version="1">MSSPSSEEKQEDRFTTARNELYQSHSLDPNTHTLPSGETKPYETHYAEKMEKFLTQRSPSASEVLRLAIIGQHFRRWEVPRSSYPDGKPGYLRWRSDLKKRQAAQVGGILMSSGYDSDETDRCRALIEKEGLKKAEEDEEVQVLEDVACLVFLDDQFEEFKEKHDEEKMVGILSKTWGKMSERGRELAMGLPMTDEARALVGKALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="STRING" id="336722.F9X528"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38930"/>
    <dbReference type="eggNOG" id="ENOG502RAW0">
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    <dbReference type="InParanoid" id="F9X528"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="17809" checksum="185850279DC5CB63" modified="2011-10-19" version="1">MKEHLYDGPGTFDKDPDEEGFFVLIQGFHDIHCLNELRKALYFNKPYYKQYEDDTKVTEPNRRSHINHCLDNVRERLMCTADIGLIPSVYTGPHSEAIKFANQHKCHNYNALLEWKQQWEAKHPAFVHAGSKHELLPVRPPPDAIFHDPSTLS</sequence>
</entry>
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        <recommendedName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13404188"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91745"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.561"/>
    <dbReference type="eggNOG" id="ENOG502RXYF">
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    <dbReference type="OrthoDB" id="3942062at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="698" mass="76450" checksum="ADEEE51AF51C6B27" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5T0</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_70316</name>
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    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854023.1">
        <property type="nucleotide sequence ID" value="XM_003853975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5T0"/>
    <dbReference type="STRING" id="336722.F9X5T0"/>
    <dbReference type="GeneID" id="13395445"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70316"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5T0"/>
    <dbReference type="OMA" id="EHTARCQ"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="431" mass="48197" checksum="5C15D05D3F8D9429" modified="2011-10-19" version="1">MSSQFTSPFLIKDHILRAQHTRERIAATELGQENALRVHVRQYIPKSNSHPRPGDVTIIGAIADAFPKEMYEPLWEAVMKGLEGKGKSVRAIWVADPVNQGESGVLNERILGPDPSWFDHARDLMFLINQFQDEIPHPIVGIGHSMGASHLAHLALLHPRLMDAVVLMDPVIQRGGGGSNWAAASTYRRDLWPSRHVAAEKLRSSPALKLWDPRVLEAFIQHGLRELPTEQYPNLPADSKNGDVPVTLQTTKAQEVYNYIQPMYHDERLMVPESERHRDFSAEDLALAPNAAFNRSEKIMLHRRLPEIRPSTLFVFGATSGVSSADLRKEKLDITGTGPGGSGGAKVGRVKEAVIQCGHLVPLEKPDESGEACARFVSDELDRWARVEKERWEIRGRLTREQRVGINEIWKRNIGGPPGKRRKEETGAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5T3</accession>
    <name>F9X5T3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MYCGRDRAFT_70324</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854257.1">
        <property type="nucleotide sequence ID" value="XM_003854209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5T3"/>
    <dbReference type="FunCoup" id="F9X5T3">
        <property type="interactions" value="932"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5T3"/>
    <dbReference type="GeneID" id="13395444"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70324"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.894"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="InParanoid" id="F9X5T3"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="140"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="467"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Conde-Ferraez L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="321" mass="35724" checksum="B41D3FA2B2CCAC76" modified="2011-10-19" version="1" fragment="single">FLTAKQSSALFAPTNPEDDGEECLHDCETCTISYPRKFEIDEDDKLYGEIQGWSRHLIVATGKTDWVRDVADEKDSVMEAVAKHTEAVQGGKLMLSASNIPVPEIVDEKEQHIGPYGKERPTTVLLMPAFTFVDNVRPIHVPELITSVINTATTNTTRLAPQITPTQSLDALPANLSTRPCPHRAVILLCSQATRDARCGQSAPLLRRELERHLRPLGLYRDLHDERPGGVGIYFISHVGGHKYSANMMVYRRGDEPDQGSEGSVETGKAPGEAMQCIWLARIRPEDCENVVRYTVLQGKVVKPERQLRGGFDRGRAIVSW</sequence>
</entry>
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        <name type="common">Speckled leaf blotch fungus</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X664"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91549"/>
    <dbReference type="eggNOG" id="ENOG502R2H3">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613950_0_0_1"/>
    <dbReference type="InParanoid" id="F9X664"/>
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    <dbReference type="OrthoDB" id="3903561at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="525" mass="58259" checksum="85F2C622D1D4D03C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6L8</accession>
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        </recommendedName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="InParanoid" id="F9X6L8"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50816" checksum="AC0170106EF25424" modified="2011-10-19" version="1">MAASIERLSLTKKRRLSTSADMQLAIAQPGSIKINVTGAYIIDHEDDDASPERSPISAVSDSPPEDAPFQHHKRDIRLPNHTSVVSHVAADIGGSLAKVVYFTRENGNAESGGRLSFLSFETEKIDECIEYLRTLQVKHQQSTTDGKSPTTLSIMATGGGAFKFYDRIRAKLGVEVEREDEMACLIHGLDFFITQIPNEVFTYDDSDPENAIEFQEPKGDVYPYLLVNIGSGVSMIKVSAPSQYQRIGGTSLGGGTLWGLLSLLTGARNFDDMLAMADKGDNSNVDLLVGDIYGEGTGYEKIGLSEKTIASSFGKVLKRKREAERVAEDGGGCSNGEEERRAKSSRMDFDGEDRSNGVVDAGRMFKPEDISRSLLYAISNNIGQIAYLQSEKHDLKRIYFGGSFIRGHQQTIHTLSFAIKFWSKGLKQAFFLRHEGYLGAVGAFVKREVGGWGRRGSVEPGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6P5</accession>
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        <name evidence="12" type="primary">PDB1</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003854594.1">
        <property type="nucleotide sequence ID" value="XM_003854546.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X6P5"/>
    <dbReference type="FunCoup" id="F9X6P5">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6P5"/>
    <dbReference type="GeneID" id="13404021"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69357"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.168"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="InParanoid" id="F9X6P5"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial nucleoid"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
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    </dbReference>
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        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP89570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="374" mass="40585" checksum="EB295039F3A474B9" modified="2011-10-19" version="1">MVAARFVRPAAQLLRTQPSAALSRSTFQKLSVPAVSRWRNYATGQKEMTVREALNEAMVEEMEKNPKVFVLGEEVAQYNGAYKVTKGLLDRFGDKRVIDSPITESGFCGLTVGAALAGLHPVCEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVAPYSAEDAKGLLKAAIRDPNPVCVLENELLYGLSFPMSEEAQSDDFVIPFGKAKIERPGKDLTIVTLSRCVGQSLQAAEILKSKYGVEAEVINLRSIKPLDVEAIVKSVKKTGHMMAVESGFPSFGVGAEIIALTAEYAFDYLEAPPVRVTGAEVPTPYAQKLEEMAFPTEQLIADYAAKLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6Y6</accession>
    <name>F9X6Y6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_80044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853922.1">
        <property type="nucleotide sequence ID" value="XM_003853874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6Y6"/>
    <dbReference type="STRING" id="336722.F9X6Y6"/>
    <dbReference type="GeneID" id="13395533"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80044"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1964928_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6Y6"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="13858" checksum="03E7F8A97E5B9314" modified="2011-10-19" version="1" fragment="single">MVEKVGHSKRMQVTRRAWLDDTKPNRQGLDPDVQMSGANGEDNTDANGQREESPMFGDNVGVGPREDELDALMAESGGNTEPGRDNTRPDRTDGLRDEPDDDELDALLAENDAAAAPPQPAKTRGPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7C2</accession>
    <name>F9X7C2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853954.1">
        <property type="nucleotide sequence ID" value="XM_003853906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7C2"/>
    <dbReference type="STRING" id="336722.F9X7C2"/>
    <dbReference type="GeneID" id="13404293"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37869"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.754"/>
    <dbReference type="eggNOG" id="ENOG502SRHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="InParanoid" id="F9X7C2"/>
    <dbReference type="OMA" id="NNYKRAM"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18534" checksum="D8775E10A3E56A75" modified="2011-10-19" version="1">MEAARKAIQTGATALVSFAGPQPPAKGTPVSAFYDRLFRLINEDKENSIRRCLVLATPSFQVAEDRSSWKWWLIVSVIRMLGGDAYADIVGIGKVVSALPVDEIEWTLFRVPVLTNGDYEPVRTAMIDDGNDGLTLSRKSNAVWVLQELEERKWVGRAPALSNPGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X858</accession>
    <name>F9X858_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_70653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852826.1">
        <property type="nucleotide sequence ID" value="XM_003852778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X858"/>
    <dbReference type="FunCoup" id="F9X858">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X858"/>
    <dbReference type="GeneID" id="13397148"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70653"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="InParanoid" id="F9X858"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="560" mass="62548" checksum="079176B3B13724D1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8E3</accession>
    <name>F9X8E3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_41234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853004.1">
        <property type="nucleotide sequence ID" value="XM_003852956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8E3"/>
    <dbReference type="FunCoup" id="F9X8E3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="13400221"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41234"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.454"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019268_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8E3"/>
    <dbReference type="OMA" id="GREVWWH"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="578" mass="64895" checksum="55F05D75A07436F9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="737" mass="80897" checksum="21EB8412E05E7022" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="598" mass="67956" checksum="CA0CE0CB3A5192AE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAR5</accession>
    <name>F9XAR5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_104368</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852069.1">
        <property type="nucleotide sequence ID" value="XM_003852021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAR5"/>
    <dbReference type="SMR" id="F9XAR5"/>
    <dbReference type="FunCoup" id="F9XAR5">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAR5"/>
    <dbReference type="GeneID" id="13393845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104368"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.107"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="F9XAR5"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="87"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="290"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="457" mass="51534" checksum="B262A9527F11B07D" modified="2011-10-19" version="1">MSAGEEDLIDYSDEELQPNEATTGAVGANGEAKKGDLSANGGADKAKGSYVGIHSTSFRDFLLKPELLKAITDCGFEHPSEVQQNCIPQAILGTDVLCQAKSGLGKTAVFVLSTLQQMEPVNGEVSVLVLCHTRELAFQIKNEYIRFSKYMPEVKTEVFYGGTDIKENEKLLKNKETHPHIIVATPGRLNALVREKKLRLGSVQRFVLDECDKMLDQIDMRRDVQEIFRATPPQKQVMMFSATLSQAVRPICKKFMQTPLELFIDDEKKLSLHGLQQYYLNSKEDEKNRRLNDLLDELTYNQVIIFVKTSNRAIELDRLLRECNFPSIAVYGHLNQEERIKRYQAFKNYDKRICVSTDVFGRGIDIERINLAINYDMPDSPTNPGATDKETLNQAADTYLHRVGRAGRFGTKGVSISFVSSERDMEVLKAIEARFEKKIDEYPEGGQGTILKEGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAR9</accession>
    <name>F9XAR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_58666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852749.1">
        <property type="nucleotide sequence ID" value="XM_003852701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAR9"/>
    <dbReference type="GeneID" id="13393848"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58666"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9XAR9"/>
    <dbReference type="OMA" id="FYTRYEF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="511" mass="56678" checksum="B0BCC8C204EF2820" modified="2011-10-19" version="1" fragment="single">MPASLPDYELRTLNTTRSQESEKRHEKEEEVEEDTITGAQRHSSLNLNTAEPSTMYDRPFHTVPSDDDLDDDALIRPSTSPSSTALNRRTVRKLDTLLLPFLATLFLLNSLDKSNIGNAETAGFTHDTGLSRSDINLSMAVFFFVFVLLQPVGAALGRRFGMRRYVPLCMSLWGLATVGHIWVRKRWHLVVLRTVIAVLESGFYPTAVSYLSLFYTKFEFAVRLGWFYGMTAVAGVLGGVLSWAVFSRFPGDGGGNSGPQLPPSLTTVESGWKSWEVLFLIEGCTTMTVALIGFVWLPRSADTAWFLSEEEKAWAEKRMRLDLVGNSNEETNKEAADDEILSAVFNPQIWHLLLVNILSAMPATAFGVLLPIVVSDLSPRQRLVPILWGLVLLVIGLVIAVATPVEQYWLRYFALCVLLSGSFIASPLTVAWLANNTPEPGKRAILLGINGWGNLAGVFVSVLFTPQDRDEGYVRSFTVLLVGVLVAFAGFVLFRVLLVRENRFRERVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB32</accession>
    <name>F9XB32_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_42243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852438.1">
        <property type="nucleotide sequence ID" value="XM_003852390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB32"/>
    <dbReference type="GeneID" id="13394151"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42243"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048347_3_0_1"/>
    <dbReference type="InParanoid" id="F9XB32"/>
    <dbReference type="OMA" id="WMVVNTL"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="285" mass="30856" checksum="2F24DC1413A3DA86" modified="2011-10-19" version="1" fragment="single">VFTNKRIFSNPSLRHSQVTFAAFHFSVTALFLYIISRPKIGMFTAKRVPVLSVLPLAMAMIPNVVLPNASLAYSSVQFYQVVRVLLTPCVLLITYLSYRTKISRPATLTLIPVCVGVAIVSYFDAAPTSKAEEKETSLLGVFFAFSGVIASSAYTVLIKHNHQKLDCTSHQLLLNLAAVAPIPMLYIIPFTDDITVHGSTSRSSWVLIIMSAVFACMINLSQFIIIEEGGAVTSTVVGHFKTLVIVSIGWMVSHAASYGSLGGAILALGSIGAYVCPHSKPWNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB42</accession>
    <name>F9XB42_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_72632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852433.1">
        <property type="nucleotide sequence ID" value="XM_003852385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB42"/>
    <dbReference type="ESTHER" id="zymti-f9xb42">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13394155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72632"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.794"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="F9XB42"/>
    <dbReference type="OMA" id="GCAGKAD"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130614" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="28"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="578" mass="62036" checksum="E838DCED0F451103" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB91</accession>
    <name>F9XB91_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly complex 1 subunit B/CAC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NFB2401</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_71863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852101.1">
        <property type="nucleotide sequence ID" value="XM_003852053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB91"/>
    <dbReference type="FunCoup" id="F9XB91">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB91"/>
    <dbReference type="GeneID" id="13393876"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71863"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="InParanoid" id="F9XB91"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="313"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="740" mass="78691" checksum="2061F55196AC5B11" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB1</accession>
    <name>F9XBB1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_71874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852114.1">
        <property type="nucleotide sequence ID" value="XM_003852066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB1"/>
    <dbReference type="FunCoup" id="F9XBB1">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="13393890"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71874"/>
    <dbReference type="eggNOG" id="ENOG502R9IN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023134_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBB1"/>
    <dbReference type="OMA" id="WNNDAHN"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="382" mass="40258" checksum="7A866B530200F305" modified="2011-10-19" version="1">MAPHLPLSAPSIHRSSRPRFTLHLTLHDLNNVPLVSGTSFIKWHLPHSTSAEHRGRTAKCAIKDHRVTYNYSKSIPVALKVGKGGVLQECRLEMEVVQEYSKGGRGERIVLGEVGLNLAEYVTPSSAGGADDGTITRRYLMRSSKINSTLKISILMTHTSGPIDFTAPTLKSAPVFGGIAGIMNTSTPATSRPLPPQPNFSASSRETGEMQDMYRRTLAAFWSSGPGELRADECIEDIFAGGDGWGRKGRPTAPATSNTMHNGRGGGQGGSPMGSGTSTPNVGESQGGGGGGGGTGKRDLSSGGGGGGGMRPTWQHTHAQAYQGGGGGGGAGNHQRQASQGRNRAEMASAEARRREGIAGQLEEMDVREDLVSWRISEKAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBX9</accession>
    <name>F9XBX9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_41752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852665.1">
        <property type="nucleotide sequence ID" value="XM_003852617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBX9"/>
    <dbReference type="FunCoup" id="F9XBX9">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBX9"/>
    <dbReference type="GeneID" id="13396987"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41752"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.306"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="InParanoid" id="F9XBX9"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="277" mass="31048" checksum="D02EED249C804DF7" modified="2011-10-19" version="1">MATVENPASLQEVQNSRKLLDPSELGTKEYWEAAYAREIRNFEDDGEDEGTVWFEDSNAEDTVLMKLNEYDEQGLGLLNRESSRFLDLGTGNGHMLFALREENEDGVRWTGDMIGVDYSPASVQLARQVDLQRLAALNDGEGDYDAGNEKPSKYASIRFEQWDILAEQPGDWLQDGFDAVLDKGTFDAISLMPHEAQAPHPCEVYLEKVVALIKPGYFLVITSCNWTKDELIDWLAPEGGDLTFFDDAKYRTYTFGGQTGSSVVTIVFRRTTEVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC40</accession>
    <name>F9XC40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_93463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852486.1">
        <property type="nucleotide sequence ID" value="XM_003852438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC40"/>
    <dbReference type="FunCoup" id="F9XC40">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC40"/>
    <dbReference type="GeneID" id="13394106"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93463"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.682"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="InParanoid" id="F9XC40"/>
    <dbReference type="OMA" id="PFFHMLE"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="74"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP87462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="30335" checksum="A79728685D36A770" modified="2011-10-19" version="1">MAPAAVETNEPPQPTSGLLAAQPTPGPQWTVDGVLATLDEKPIPNSNSPLAFFHILERLKTTKREGWRRFDIFHGESIADHMYRMSIITMLCPPALASRLDLSRCTKMALVHDMAELLVGDITPVDGVEKSEKSRREADTMDYLCDKLLGSVHGGTVGKQIREVWQEYEDSETLESHFVHDVDKMELLLQMMEYERQNKGKVDLGEFSRVAKRIVLPEVQEWASELLVERNEFWKKSGKEPSGVLDISEELRQQQDAYYGNGVNGNAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCL5</accession>
    <name>F9XCL5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ribosomal RNA assembly protein KRR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_109531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852221.1">
        <property type="nucleotide sequence ID" value="XM_003852173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCL5"/>
    <dbReference type="STRING" id="336722.F9XCL5"/>
    <dbReference type="GeneID" id="13396917"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109531"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325224_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCL5"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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            <end position="505"/>
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    <sequence length="887" mass="98294" checksum="39394CF7BA049007" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCM9</accession>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 115943 / IPO323</strain>
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    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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    </dbReference>
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        <location>
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    </evidence>
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    </evidence>
    <sequence length="1042" mass="113860" checksum="1592B3F988504D66" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCS9</accession>
    <name>F9XCS9_ZYMTI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851385.1">
        <property type="nucleotide sequence ID" value="XM_003851337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCS9"/>
    <dbReference type="GeneID" id="13401292"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86396"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.148"/>
    <dbReference type="HOGENOM" id="CLU_1826832_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCS9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="141" mass="14591" checksum="A61E7D305B171EA5" modified="2011-10-19" version="1">MYRKTLIEHCAAAFEPDVTELVGDSLVIRRESGAGAVTSSVGGPPPGKAALLLILYTVGYTQCIAQIPVASAVMSAFLALDMDSGSARSPEQRRESSASDDAQARYIADTIGTHPRPSSGARPATPIGQRTARSSTSDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCX2</accession>
    <name>F9XCX2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_100444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851411.1">
        <property type="nucleotide sequence ID" value="XM_003851363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCX2"/>
    <dbReference type="FunCoup" id="F9XCX2">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCX2"/>
    <dbReference type="GeneID" id="13393696"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100444"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.191"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCX2"/>
    <dbReference type="OMA" id="KIRMWEI"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67845" checksum="ED7663E2F285F4E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCY8</accession>
    <name>F9XCY8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_72926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851911.1">
        <property type="nucleotide sequence ID" value="XM_003851863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCY8"/>
    <dbReference type="STRING" id="336722.F9XCY8"/>
    <dbReference type="GeneID" id="13393688"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72926"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028895_3_1_1"/>
    <dbReference type="InParanoid" id="F9XCY8"/>
    <dbReference type="OMA" id="RNHANRP"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15242" checksum="AE5DD14BB7D74D17" modified="2011-10-19" version="1" fragment="single">MIGMETYNGHVRTPADAIILFEACRIGLLPRVQRRLSEKERQSIKSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGNSSNAARDSTNPPEADSDGGGPDGYRYKPDGLMKQSFSITTNSGQHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCZ0</accession>
    <name>F9XCZ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_43325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851910.1">
        <property type="nucleotide sequence ID" value="XM_003851862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCZ0"/>
    <dbReference type="STRING" id="336722.F9XCZ0"/>
    <dbReference type="GeneID" id="13401403"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43325"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_2_1"/>
    <dbReference type="InParanoid" id="F9XCZ0"/>
    <dbReference type="OMA" id="TVENFVY"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="277"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP86886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="691" mass="76928" checksum="32D788D4F13F7B5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD75</accession>
    <name>F9XD75_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_73051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851461.1">
        <property type="nucleotide sequence ID" value="XM_003851413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD75"/>
    <dbReference type="FunCoup" id="F9XD75">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD75"/>
    <dbReference type="GeneID" id="13401444"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73051"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.288"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60022" checksum="845F500E0C15B7E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA6</accession>
    <name>F9XDA6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARE1</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_44439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDA6"/>
    <dbReference type="FunCoup" id="F9XDA6">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDA6"/>
    <dbReference type="GeneID" id="13393634"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44439"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_1_1"/>
    <dbReference type="InParanoid" id="F9XDA6"/>
    <dbReference type="OMA" id="INWWYVA"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="599" mass="69287" checksum="5A4366C408E0D21E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDH4</accession>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDH4"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104876"/>
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    <dbReference type="HOGENOM" id="CLU_2322190_0_0_1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="99" mass="11043" checksum="795CADD975CC497D" modified="2011-10-19" version="1">MCSFNDDPSAAPINPLQQRHPDRNSNQSERQPKAAPIARSRSFATSRATIKSEDTLPLQKSTTAHPHDDRASHCTNHSYHRNILATPIPTILQMAHPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE97</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1877090_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE97"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="136" mass="15140" checksum="E9A773C98D951AD8" modified="2011-10-19" version="1">MKIRLHLLPPFSAQEFSKSSYSRPLHPLLHLTLPNNPLPTRKPLKHPQRMLPNLLRQSLLPHRTHALPTSDCLPIPMDQIRSAADEAIRTNQPLLFVALHFHQLSPSHFTLVDGGAVHSGMADAAGGELHPIHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEP9</accession>
    <name>F9XEP9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
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    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_110080</name>
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    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850600.1">
        <property type="nucleotide sequence ID" value="XM_003850552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEP9"/>
    <dbReference type="FunCoup" id="F9XEP9">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEP9"/>
    <dbReference type="GeneID" id="13401104"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110080"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.99"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEP9"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="85"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="55820" checksum="FB313785568FEC61" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEQ8</accession>
    <name>F9XEQ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_44624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851269.1">
        <property type="nucleotide sequence ID" value="XM_003851221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEQ8"/>
    <dbReference type="FunCoup" id="F9XEQ8">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEQ8"/>
    <dbReference type="GeneID" id="13395332"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44624"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="F9XEQ8"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="202" mass="22702" checksum="852E4C32A55BDA31" modified="2011-10-19" version="1" fragment="single">EVLLGITGKDFTIIAASKAAMRGATILKASDDKTRTLNTHTLMAFSGEAGDTVQFAEYVQANVQLYSMRNSNHLTPYETASFIRSELAKSLRSRNPYNVNLLLGGYDTIADKPQLFWIDYLASCAPLPYAAHGYAQYYCLSTLDKHHHPDITFEQGMKILRMCTDELKRRMPVDFKGVLVKVITKDGVREEPYPDNFNVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFJ3</accession>
    <name>F9XFJ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_44980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850940.1">
        <property type="nucleotide sequence ID" value="XM_003850892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFJ3"/>
    <dbReference type="STRING" id="336722.F9XFJ3"/>
    <dbReference type="ESTHER" id="zymti-f9xfj3">
        <property type="family name" value="Thiohydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="13397680"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44980"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.851"/>
    <dbReference type="eggNOG" id="ENOG502RZEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_1_1_1"/>
    <dbReference type="InParanoid" id="F9XFJ3"/>
    <dbReference type="OMA" id="PNYENRT"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="310" mass="34226" checksum="4E0F4F78BD857112" modified="2011-10-19" version="1">MSDANGTRFSVEKISFRTMDGLQLCGNLYPAAQRGPAVIINPGMGCVKEMFVPDVAQYLQKAGITAFAYDPRNLGESEGSPRNEIDPHKQISDYSDALTFLKGQPIVDSTQIVFWGQSFAGAAALCAAALDHRAKAVVAVCPNLKFDRDWTRYRAALAKSMQDRESQMAGNDPYYLPILDINFESPGGMSNGVKSSEAEYMRTLKSLGAVNYENRLTVQSYYKILTWSPLSLIARLETPTLVIIPELDTLSPFEEQMAMTESLQCPKKVHIAPGRNHMDVLTGDGFDALCQMQLDFIMESVGAEEDRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFT3</accession>
    <name>F9XFT3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_81585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851153.1">
        <property type="nucleotide sequence ID" value="XM_003851105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFT3"/>
    <dbReference type="GeneID" id="13397445"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81585"/>
    <dbReference type="HOGENOM" id="CLU_2607872_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFT3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="79" mass="8864" checksum="B266207B306A1E15" modified="2011-10-19" version="1">MKKQPITGFHALKSHIYLPKCVIAADGYSSHLEISSQTSVVRSMICRHLAPTSSKKHVTDRRRLRIGSSVGHDRFTVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGH6</accession>
    <name>F9XGH6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_94250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850587.1">
        <property type="nucleotide sequence ID" value="XM_003850539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGH6"/>
    <dbReference type="GeneID" id="13395314"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94250"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="F9XGH6"/>
    <dbReference type="OMA" id="GICAKME"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35101" checksum="5A61F1FDD2C8F200" modified="2011-10-19" version="1">MDEKNRPVDASGFEETEYEAQHFELDAEWQHASSSKAERALVRKLDWRLVPACWLINAKIGGLEEDFDLTSNQYSVIVLVFFVSYILAEVPSNMVLSRVKPHLFLPLLGVFGDWWQHAWVQHRTRLRLSFSEFCSILEGVASIVGAVVIFFVLPDFPSSTTRNGFLTEEERTLACNRLAAEGFGLTQGPQRKVGHWKAFKMVCADWRTWGLALLFVLNTGSQTMQYFIPCLVKSFGWRGKTAQFIFAFGPIYSCSALIKTWISHILGYPAEKRAVAIALINALGNASSIYGSFLWPKENGPQYLVGFGPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGR9</accession>
    <name>F9XGR9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851010.1">
        <property type="nucleotide sequence ID" value="XM_003850962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGR9"/>
    <dbReference type="GeneID" id="13397571"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94691"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.623"/>
    <dbReference type="HOGENOM" id="CLU_863837_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGR9"/>
    <dbReference type="OrthoDB" id="10344611at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="322" mass="37079" checksum="EF25112DA4151AEF" modified="2011-10-19" version="1">MSAPKYFIPLCYSSNPKRKAEDDGRDGIEDKKIFTDDDLVKMATKMTIDLDPDQQRLPNEIMEQICEFVALSARPIEIPLDTQALAMPEDLRHVKPAMFKDLDGMFNASRTTRRMLATHMLHRTTFTTRLDLATPPFMTIAAAFNLSKLPDIIRKNIRKIQVQVYFTGPATVNAVEEWARIWYEPGLLRQTSRIEVEQEVEVRAVTRNWDDSDGFTTEDGRRFWPWGAEIAECFLDDVRTVAEDLVWEENRQAANDPDFVIGVNLPELKKRVANMTADEHCDEHLEGSGWKRNCCWKCFHHEVHAGWARSAGLPEKEVPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGZ8</accession>
    <name>F9XGZ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_75105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850256.1">
        <property type="nucleotide sequence ID" value="XM_003850208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGZ8"/>
    <dbReference type="FunCoup" id="F9XGZ8">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGZ8"/>
    <dbReference type="GeneID" id="13394684"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75105"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.641"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021711_3_0_1"/>
    <dbReference type="InParanoid" id="F9XGZ8"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000144">
        <property type="term" value="P:positive regulation of DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="449" mass="49104" checksum="E4B99D1B2AE549F0" modified="2011-10-19" version="1">MSVWNPENVTDVAESVGIASLNRDVAEHLARDVEYRISQVLEEALKFMRHAKRTTLTTQDISQALRLLEVEPLYGYESTRPLRFGEASIGPGQPLFYVEDEEVDFEKLINAPLPKVPREISFTAHWLAVEGVQPSIPQNPTQADQRNQELAAKGQGANTLAAVSGNDNVAVKPLVKHVLSKELQLYFERICSAILDELNEEYRTAALASLQTDPGIHQLVPYFIQFVADKITHNLKSLFILTQSLQLINALLENRSLFIAPYVPSIIPSVLTCVVGKHLGSVSADGTTVHFSLRDYASSILSGIARKYGSSSSTLKPRIARSCLKHFLDSHKPFGTHYGAVLGLTMIAGAAGVRSLILPNLKSYDEHLRGGLKDESKSEQAEYVVGAIMQALATLEQDAVGAAHANGHPEGDALKERLTEQVGETIATRIVESGRQGLINAVLEKDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH01</accession>
    <name>F9XH01_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deacylase-like protein</fullName>
            <ecNumber evidence="6">3.5.1.-</ecNumber>
            <ecNumber evidence="6">3.5.1.81</ecNumber>
            <ecNumber evidence="6">3.5.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DAC</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_110592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="6"/>
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    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850206.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13394682"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110592"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.644"/>
    <dbReference type="eggNOG" id="ENOG502SKWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_2_1"/>
    <dbReference type="InParanoid" id="F9XH01"/>
    <dbReference type="OMA" id="GRTNMLH"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:N-acyl-D-amino-acid deacylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:N-acyl-D-aspartate deacylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AstE_AspA_cat"/>
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    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="5">
        <location>
            <begin position="81"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="372" mass="39958" checksum="A49F2C9E0633FAA4" modified="2011-10-19" version="1">MKLPSQSTFALVAFAAFSYAKTIYTGDTLQGYPVIASLDINDVPANQISRFWLSPASGQGGLPYFLPIFVARGSEESLETGRKFSLSASIHGDELNPVAVVQKVFARLNETVASGDFNGTVIGLPTQNPNGNLMNQRYFYTSSSNGFLTDLNRNFPGMSIAEGGSLPMSYTAAIWNNIWGNTSNVDIAVDLHTLSTGSIGPLWVYADYALEGVQRIAELAQPDMIKIDPGQSGTIETSFVERGIPAITMEIGPANNWNGTLISRAVDFVFRLMDDLQMTTGETPTPDLSNTYIANNFSDVTVSHSGWVELDVTTMYDVTEGQVVGRVYNSWGDVLETLTSAVDGRVLTALVDPAVEAGAGVLTIGYNATNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHJ7</accession>
    <name>F9XHJ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850018.1">
        <property type="nucleotide sequence ID" value="XM_003849970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHJ7"/>
    <dbReference type="FunCoup" id="F9XHJ7">
        <property type="interactions" value="1192"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHJ7"/>
    <dbReference type="GeneID" id="13394986"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74700"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="InParanoid" id="F9XHJ7"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="657" mass="73518" checksum="6F4D8BF6AAC5DAD1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI00</accession>
    <name>F9XI00_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850065.1">
        <property type="nucleotide sequence ID" value="XM_003850017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI00"/>
    <dbReference type="GeneID" id="13394266"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105493"/>
    <dbReference type="HOGENOM" id="CLU_2943629_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI00"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="60" mass="6803" checksum="94FB798CBAF385FC" modified="2011-10-19" version="1">MSRRIRTQATDLHRMQPCLSKVPLEPGSHRFAARLWSEKIAAVPPFDAGTRQMSRRGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI09</accession>
    <name>F9XI09_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine kinase</fullName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
            <ecNumber evidence="5">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_74864</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EC" id="6.3.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850070.1">
        <property type="nucleotide sequence ID" value="XM_003850022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI09"/>
    <dbReference type="STRING" id="336722.F9XI09"/>
    <dbReference type="GeneID" id="13394271"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74864"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021258_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI09"/>
    <dbReference type="OMA" id="CLMEERH"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000016">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
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    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="519"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="703"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="712" mass="76183" checksum="186E389D536F9532" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
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                <person name="Foster A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849693.1">
        <property type="nucleotide sequence ID" value="XM_003849645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIT6"/>
    <dbReference type="GeneID" id="13399108"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95752"/>
    <dbReference type="eggNOG" id="ENOG502SIWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="F9XIT6"/>
    <dbReference type="OMA" id="IHECHLS"/>
    <dbReference type="OrthoDB" id="3641893at2759"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="650" mass="74025" checksum="3F44CBD6313A0DFD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIV6</accession>
    <name>F9XIV6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_75621</name>
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    <organism evidence="12 13">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849681.1">
        <property type="nucleotide sequence ID" value="XM_003849633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIV6"/>
    <dbReference type="FunCoup" id="F9XIV6">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIV6"/>
    <dbReference type="GeneID" id="13402215"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75621"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.361"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_1_1"/>
    <dbReference type="InParanoid" id="F9XIV6"/>
    <dbReference type="OMA" id="SQKEMRF"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="145"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="394" mass="43100" checksum="4F7971C222D80C45" modified="2011-10-19" version="1">MAGPDLSQISSNWKILQERLKAGKRQDQKVASIKAATNGAGIKRKRPSTTDTKPPSAIKKSRFTISDANTTSLPRKKRPSSTSKMGALTSTPTSTTTAQKASRLIHDHDIPAADISAAYGTTTTSLTQPTDQINIGHHPTHVPGKFLALDCEMVGTGPPPHVDNLLARASLVNFHGQQVYDSYVLPPAGMKVQDYRTHVSGIQPHHMRAPFARPFEVVQRDIADLLEGKVLVGHAVRNDLNVLMITHPKRDIRDTSRYAKYRVESRGKPPALRKLAKSELGLVIQTGEHSSIEDARATMALFRKEKVGFEVENRKVFGQPRKVGKGGKAREESVEDESEEEDDVVESDGDLDLIDGEEDDEFADELPVTERVGAGGGAGGGTKKKKKKKRTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJC6</accession>
    <name>F9XJC6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_47232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849653.1">
        <property type="nucleotide sequence ID" value="XM_003849605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJC6"/>
    <dbReference type="FunCoup" id="F9XJC6">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="13402249"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47232"/>
    <dbReference type="eggNOG" id="ENOG502S0C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_2_0_1"/>
    <dbReference type="InParanoid" id="F9XJC6"/>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="540" mass="59097" checksum="488F81AED7106037" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJH4</accession>
    <name>F9XJH4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_47222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849769.1">
        <property type="nucleotide sequence ID" value="XM_003849721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJH4"/>
    <dbReference type="STRING" id="336722.F9XJH4"/>
    <dbReference type="GeneID" id="13399044"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47222"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.199"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050394_1_1_1"/>
    <dbReference type="InParanoid" id="F9XJH4"/>
    <dbReference type="OMA" id="CEDFPWI"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="230" mass="25528" checksum="C47EFA13FBBF7579" modified="2011-10-19" version="1">MADEAPTFRLFVASFTDFLVVAIHTILYERGIYPQTSFLSARRYNFAVRQSRHPKVCEWITDAVASVESELLKGTVDRISVVIYSKQNKPLERFMFDVSRFPTVPTSDLDVPLESADVEGSSPSVLPLVDLEEQMRATMSRLSNCSASLDVLPKSCTFTIAVELKGEDDAPLTHPQPWIPVQGSDESLGEVNGKRTLPLRAVRAGEMAFETWVEELSEKAAQDSNTSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKE1</accession>
    <name>F9XKE1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849533.1">
        <property type="nucleotide sequence ID" value="XM_003849485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKE1"/>
    <dbReference type="GeneID" id="13402375"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95957"/>
    <dbReference type="HOGENOM" id="CLU_437563_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKE1"/>
    <dbReference type="OrthoDB" id="10522595at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="625" mass="70476" checksum="EAE32A27FA521CE0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKL3</accession>
    <name>F9XKL3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849238.1">
        <property type="nucleotide sequence ID" value="XM_003849190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKL3"/>
    <dbReference type="GeneID" id="13398785"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96020"/>
    <dbReference type="HOGENOM" id="CLU_1662192_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKL3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="159" mass="17521" checksum="77F0C185FB4328B7" modified="2011-10-19" version="1">MDFLHQITARLTPSATPPQLAGMASSAREWGTELLRHTLNSGIVSADWMQLVNQMVLPPVTSHSEAFSICRFRVSDRNQFSSSSADPVGGKARVKRRRWRDDDLVFLDHCGNGMESSLPREAAGRPAGSGIVEHRKTNEQMSLSADLLLFAAMVESPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLL5</accession>
    <name>F9XLL5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848824.1">
        <property type="nucleotide sequence ID" value="XM_003848776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLL5"/>
    <dbReference type="STRING" id="336722.F9XLL5"/>
    <dbReference type="GeneID" id="13398642"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105896"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.186"/>
    <dbReference type="eggNOG" id="ENOG502S6B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078556_2_0_1"/>
    <dbReference type="InParanoid" id="F9XLL5"/>
    <dbReference type="OMA" id="GKDWFAC"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391752" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="21450" checksum="0799A2AB6A858CC9" modified="2011-10-19" version="1">MKTACALLFAAVAAAGPIRAIPPGTTFDPLPDAPLNFTATALYVGGDLGFPINANDKRFWIGKDTRTFSEEQDKQANTDKTIFSFAEGTGQLNLDVNVPGGQRVYVRDDGQLRFVEAHRLRTDGHATFTGFEIGDGALLKFEAQDWIMCPKEYGSSEFKVWAASRVQDLKEGCVRFEWQNDYTRYPEAWAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLZ2</accession>
    <name>F9XLZ2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CYP-46</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_48855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849029.1">
        <property type="nucleotide sequence ID" value="XM_003848981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLZ2"/>
    <dbReference type="FunCoup" id="F9XLZ2">
        <property type="interactions" value="1441"/>
    </dbReference>
    <dbReference type="GeneID" id="13398351"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48855"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.489"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="F9XLZ2"/>
    <dbReference type="OMA" id="HHAHEST"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="542" mass="59911" checksum="17828059E4F40AF7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM33</accession>
    <name>F9XM33_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Grg1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_88109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848543.1">
        <property type="nucleotide sequence ID" value="XM_003848495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM33"/>
    <dbReference type="STRING" id="336722.F9XM33"/>
    <dbReference type="GeneID" id="13396439"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88109"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.417"/>
    <dbReference type="eggNOG" id="ENOG502S6FD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179513_0_1_1"/>
    <dbReference type="InParanoid" id="F9XM33"/>
    <dbReference type="OMA" id="HESKHDA"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="8996" checksum="498B15EA0B769DC6" modified="2011-10-19" version="1">MSAPNANAPNEGIVGQIANSVSNAANYVSESLQGKSAEASKEANKEQAKGNVPGNNSITDRVSGALGAASDKAEQSKHEASKEANKQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMJ3</accession>
    <name>F9XMJ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_111173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848280.1">
        <property type="nucleotide sequence ID" value="XM_003848232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMJ3"/>
    <dbReference type="GeneID" id="13396333"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111173"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.63"/>
    <dbReference type="eggNOG" id="ENOG502SUTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="TEFSYVT"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23998" checksum="C8F9EF94FAEB6F0F" modified="2011-10-19" version="1">MPTTEIFIAALKPGSNIGDPSNEAAQTLKSVGDTLIQTDGVQDIHFGMQVESPNTLQLLVTWDKLDSHKTFMSTPTYKPFVDRILALIDGAPSMIHTDLEPTASVAPALAAPVTEIATFYFGGEAPEDYISGVHKFRDILEKEKSDGYLGAAIGLTVEEVEREGHKGKGAVLVIGWESVEKHMAFRETGTFKENIGLLRNGAKTLEMHHVPFMEFVREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN42</accession>
    <name>F9XN42_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_50095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848603.1">
        <property type="nucleotide sequence ID" value="XM_003848555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN42"/>
    <dbReference type="GeneID" id="13396276"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50095"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.273"/>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN42"/>
    <dbReference type="OMA" id="KFVCYGG"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="548"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114187" checksum="E27CA9CA42C3FE8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNL3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97006</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848172.1">
        <property type="nucleotide sequence ID" value="XM_003848124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNL3"/>
    <dbReference type="GeneID" id="13401617"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97006"/>
    <dbReference type="HOGENOM" id="CLU_973889_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNL3"/>
    <dbReference type="OrthoDB" id="10564292at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="286" mass="31443" checksum="08E847784785A1DB" modified="2011-10-19" version="1">MEAELARRALIFQQASCNTPKVTIPALSLACLDDGQQQIATIPLANVYDGTTSTTSTTTHEPKFRKAITHTFTLKGRITDQDIVDNLIATDDARTINPAEKQHAKAHIVTAQRDDVFICTCTYDACEPPRVERRRDETGTKTGVYCNDLYPGVSGKLLDLLTLKMMMLVPTTTKNQTTNIGVEPPSTTYGNDQTAQAYEDTVLHASKVRFHQAQLPAQIVQEAEERYVEKGVGEMKEGKMEDGEMAGGERADMKKAMHTSVQTSTRILTLASRKAPASVPTKRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNR9</accession>
    <name>F9XNR9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847381.1">
        <property type="nucleotide sequence ID" value="XM_003847333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR34"/>
    <dbReference type="GeneID" id="13400132"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97641"/>
    <dbReference type="HOGENOM" id="CLU_1422475_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR34"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="191" mass="20809" checksum="7CC87EB0ED9E2744" modified="2011-10-19" version="1">MLLDPSATYRTARFPLVVSLFVECALSVVENSLRLSRDALEGSWEPTLKVWTAPLSEVRRRSLRKAGSLMDVVRVITNRAIRYGAGAAGAVQHPIVGSVRLEVEVWAEVAGKGFLKIELIAEDNETVGRSVRCVCIGGEKRRKQRGGHDSREDVAMSFFMPLLLTVVFIPRFGGLNRVEEGAMGGAAAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRC0</accession>
    <name>F9XRC0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847257.1">
        <property type="nucleotide sequence ID" value="XM_003847209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRC0"/>
    <dbReference type="GeneID" id="13399911"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97774"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.102"/>
    <dbReference type="HOGENOM" id="CLU_1723766_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRC0"/>
    <dbReference type="OrthoDB" id="3965127at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="152" mass="16948" checksum="0444FEA7F45BBF09" modified="2011-10-19" version="1">MANIAVKRGHLPLLNRIQQLKASPLPFPPLPPGGTNQQQLESSRPNQGQVVLEYDDSPSRTWRKQSPCLSRISPVSLSSESSSSTSDLHTYHSTASSPSLRSRDAVDMERPLTPIDSDGDNGKVVIRVRRFIKRDFEKQSLCIIRMNPVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRF2</accession>
    <name>F9XRF2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_29565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847201.1">
        <property type="nucleotide sequence ID" value="XM_003847153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRF2"/>
    <dbReference type="STRING" id="336722.F9XRF2"/>
    <dbReference type="GeneID" id="13399706"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29565"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_30_3_1"/>
    <dbReference type="InParanoid" id="F9XRF2"/>
    <dbReference type="OMA" id="LEEQAIC"/>
    <dbReference type="OrthoDB" id="3648557at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7810" checksum="10FDF1A3C4C30D6B" modified="2011-10-19" version="1" fragment="single">LKCGSLGLNLTAASRVVSVVIVEPPSTPFVEEQAINRVHRLNQTIDVKVFRLKIRNSVEERILELQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRX6</accession>
    <name>F9XRX6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="13399206"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97969"/>
    <dbReference type="HOGENOM" id="CLU_2279698_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRX6"/>
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        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11276" checksum="191C1291F6227C05" modified="2011-10-19" version="1">MDEPDSSTEDAVIGAAGSRAPSGELDTSHKSRQSASFNGYWPPAITIRYRESNSTEEDIEEMEESRGLLDKSGGTMSDEEEEEDIDDSVIHDMDHFKTFSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5I8</accession>
    <name>A9Y5I8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4 15">ATP synthase protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">atp8</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase protein 8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABU40275.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5I8"/>
    <dbReference type="STRING" id="336722.A9Y5I8"/>
    <dbReference type="GeneID" id="5846248"/>
    <dbReference type="InParanoid" id="A9Y5I8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009230">
        <property type="entry name" value="ATP_synth_su8_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101:SF1">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05933">
        <property type="entry name" value="Fun_ATP-synt_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008892"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABU40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="48" mass="5759" checksum="3508081C0E6649E6" modified="2008-02-05" version="1">MPQLVPFFFINQVVFAFVIFVLLVYVFSKYILPRFVRLFAARLFISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWE5</accession>
    <name>F9WWE5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_65875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856210.1">
        <property type="nucleotide sequence ID" value="XM_003856162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWE5"/>
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    <dbReference type="GeneID" id="13394615"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65875"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.821"/>
    <dbReference type="eggNOG" id="ENOG502S6JC">
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    <dbReference type="InParanoid" id="F9WWE5"/>
    <dbReference type="OMA" id="YMNILLD"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32756" checksum="09A24B6FCFACDD0E" modified="2011-10-19" version="1">MENLLSVAFDNLSSRDGQKIRKGCRQVENLLAQILLSKPNSRSPHKRKSSALNDTKQQGTSKQLDELKQDPAFREFFRLQEGFQYNVASRLMSTLECLMGMGNPSSTDLLILAALDLLQGVLLLHPPSKCLFHREIHMNMLLDLLDASNPPKIQSHALLVLVAALLGQPRNTRTFEAIDGLLTVTSLFKSRSTTKEVKMRSLEFLYFYLMPEVPTLPFTSSSAPNTAVMGRNGAGKHDLRADHARTHSGDMDIDDNDLDTRSTDDKQMLLGRYLSNVAELVGDLEESAPFSAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXE4</accession>
    <name>F9WXE4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_64883</name>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.586"/>
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    <dbReference type="OrthoDB" id="5407894at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="274"/>
        </location>
    </feature>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="625" mass="67029" checksum="F0817682D422EA3C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY99</accession>
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        <recommendedName>
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    </protein>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502S4AX">
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    </dbReference>
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    <dbReference type="OMA" id="FHMCDTG"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91506.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="856" mass="96513" checksum="49246022ED6C3D26" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857039.1">
        <property type="nucleotide sequence ID" value="XM_003856991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYF7"/>
    <dbReference type="FunCoup" id="F9WYF7">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYF7"/>
    <dbReference type="GeneID" id="13395425"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32730"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1690"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="InParanoid" id="F9WYF7"/>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29966" checksum="47D73EE0ABA93A83" modified="2011-10-19" version="1">MAGPPKKKQKREEKQEGELPQKKYYRQRAHANPFSDHDLTYPESPSAMDWSQHYPAFVQKNTSDENTHPQLTKNVTVADIGCGFGGLLFALSPKMPDSLILGMEIRTSVTSFVQDKAKALRAQHASTGEYQNVSCIRANTMKFLPNFFTKGQLEAIFLCFPDPHFKARKHKARIVSTTLNSEYAYVMKPGGKVYTITDVEDLHLWMVEHLEAHPSFERVGEEECGQDEGVATMKTETEEGKKVERNSGKKFVAVFRRLDDPPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYT2</accession>
    <name>F9WYT2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_31826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855928.1">
        <property type="nucleotide sequence ID" value="XM_003855880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYT2"/>
    <dbReference type="FunCoup" id="F9WYT2">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYT2"/>
    <dbReference type="GeneID" id="13403867"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31826"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.218"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="F9WYT2"/>
    <dbReference type="OMA" id="CRGRNGD"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP90904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="38754" checksum="554534015ADB72FF" modified="2011-10-19" version="1">MAAQQDYKFEGWMGLDKESAQGKMVWQGFQPKPFEDADVDIEIECCGICGSDIHTLRSGWGATPYPVCVGHEIVGKAVRVGSKAEKGIKVGDRVGVGAQNSSCLKPDCEECSSGLEQHCTKSVNTFADKYPDGSMSYGGYANYHRCPSHFVFKIPDSISSSDAAPMLCGGITVYSPLKNNNCGPGKKVGIVGVGGLGHFGVLFAKALGADRVVGISRRGDKREDVLKMGADQYIATEEDKDWHKKNARSLDLIVCTVSSPKMPLMRYLQLLKVKGTFIMVGAPEDKLPDMTAFAFIAKGVKFGGSMIGSPAQIEEMLQLAADKQIKPWINKYPMKDANKAIVDMEEGKARYRISLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ64</accession>
    <name>F9WZ64_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MYCGRDRAFT_66064</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856272.1">
        <property type="nucleotide sequence ID" value="XM_003856224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ64"/>
    <dbReference type="FunCoup" id="F9WZ64">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ64"/>
    <dbReference type="GeneID" id="13394753"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66064"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.937"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="InParanoid" id="F9WZ64"/>
    <dbReference type="OMA" id="VWRQFLD"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="92"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="520"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGP91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="648" mass="72136" checksum="17ACC8332D26E0B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZT1</accession>
    <name>F9WZT1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_34213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Conde-Ferraez L."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0D7"/>
    <dbReference type="GeneID" id="13395258"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107494"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1489"/>
    <dbReference type="eggNOG" id="ENOG502R944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824305_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0D7"/>
    <dbReference type="OMA" id="WAKLMNE"/>
    <dbReference type="OrthoDB" id="3646447at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="347" mass="37959" checksum="220C55714F984B8C" modified="2011-10-19" version="1">MGLLSSLVNAFRKSRRDGHDELDSSRHERAAQGRHRGNDAGRGVDIEMGRAGEQIFESGRSQRQSLSRTKSLRGSNKRRSWFGGRADADDDIPAVPAIARNQQVNANGQPRHVQIQTGYEFRGSWFLNNRQQDAGAVADLPTLPAMPVTVVHSTQPATAALPTGQQRARRASMKSQYSVARSTRSKSKSNSFWASSNPDDSDAENVPPVPALVRDDDNSPDESFESFRHDAARGRSGKPAGAKGTRPVSTTSRKSYRPKSAASGFLKSTNGATESQRRSYRNSFKLVDGSDMVCLTDDQRVAWAQLMNEGAVFDDKDDEDGKVEVSQPKDRHSNAEALAALEFGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP91531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856507.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9X0E9">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="GeneID" id="13398989"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84059"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1499"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0E9"/>
    <dbReference type="OMA" id="FGCSTFP"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="40756" checksum="A2F74D1CCC48FEED" modified="2011-10-19" version="1">MPYGPPDDPVHRSIAATKANYVRLGQSGLRVSNPILGAMSFGSSAWAPWVIEEEAALPLLKAAYDRGLNTWDTANVYSNGESERIIGKAIKEFNLPREKLVILSKCYGYVGEEPSTRGIMYGQEIAKSKEYVNRGGLSRKAIFDAVDKSLKALDLTYLDLLQIHRFDHWTPIEETMEALHDLVKSGKVLYIGASSMWTYQFAMMQHCAEKHGWTKFVSMQNHYNLLYREEEREMNKFCDATGVGLIPWAPLCRGHLARPPTDEPSTVRSTADVNSPMTTGKSEKDREIVKRVHELAEKKGWKMSHVALAWINKRVTSPIIGFSSVERIDEALDARGKVLTEEEEKYLEEPYVTRDIQGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0W2</accession>
    <name>F9X0W2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856189.1">
        <property type="nucleotide sequence ID" value="XM_003856141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0W2"/>
    <dbReference type="STRING" id="336722.F9X0W2"/>
    <dbReference type="GeneID" id="13403032"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89227"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.773"/>
    <dbReference type="eggNOG" id="ENOG502RJN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987687_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0W2"/>
    <dbReference type="OrthoDB" id="5372451at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="31220" checksum="ED20894A3F0A0ADF" modified="2011-10-19" version="1">MAQSEYDKIRRKLHTTSPIQQCLSVESASISASGSWMASMMQDAVHSVYSDDRDDIKQLEQTAFDWMDNAFFCMDLSEIQTLVRISTRKSQNMESSIRCGSSMVMRIDSDTNTVAPAMSIDGADANFTIPSFFLPSHEHLLPPRPDVRAEDQANIGFAAHLTFPAVLDRAMVDFFADLVESLIVMEIDDHEEKGCGDDAMQSKMDRVKNKFQVGVHETGRSIKKGLKKAAFKSRGDSQIAWAVNKIAEQLEILRGDVGYAGDMPVSLAFLRGSELGPTKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X114</accession>
    <name>F9X114_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_34825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856330.1">
        <property type="nucleotide sequence ID" value="XM_003856282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X114"/>
    <dbReference type="FunCoup" id="F9X114">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X114"/>
    <dbReference type="GeneID" id="13402905"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34825"/>
    <dbReference type="eggNOG" id="KOG3888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_0_1_1"/>
    <dbReference type="InParanoid" id="F9X114"/>
    <dbReference type="OMA" id="VHITWPN"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="147"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="437" mass="49769" checksum="677CF2FE82251659" modified="2011-10-19" version="1">MLHETLVVQEGSNQRPPPKHNPLGPAIFRPASLRLNLGTSIPLTIDGQEHPFNPILLRDLCSCPLCIDQSTRQKLFYSADIPADIQVSETYVKNGHFRFRWSVDAPGYGNDHVSSIPIEALERLLRTGMLDRAAPELPTRQYWTAETFDQETSDFSFDTYMNDDKALLKALRQLHTHGLMFVSGVPDDETSVEQLAERIGPLKTTFYGRTWDVRSVPDAKNVAYTAQNLGFHMDLMYMKQPPHLQLLHCIRSSSAGGASLFTDSFKAVEDLARTDLDSMATLSKVHIDYHYDHPGSQYYHRRRPVIEQRPLQRALLEPMDFVASVAWSPPFQAPPRLRGFSPGIPASAPQLLSHRYNGWHEAARKFNQLIHRPKGIYERLMKPGECVIFDNRRVLHARSAFKVGDVGKERWLRGAYIDEDPFLSKLHVMGRQEMEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X196</accession>
    <name>F9X196_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_66686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857186.1">
        <property type="nucleotide sequence ID" value="XM_003857138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X196"/>
    <dbReference type="FunCoup" id="F9X196">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X196"/>
    <dbReference type="GeneID" id="13395113"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66686"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="F9X196"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="226"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="664" mass="74020" checksum="C3FF6BE4C71C971C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Z2</accession>
    <name>F9X1Z2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854705.1">
        <property type="nucleotide sequence ID" value="XM_003854657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Z2"/>
    <dbReference type="STRING" id="336722.F9X1Z2"/>
    <dbReference type="GeneID" id="13403752"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90342"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.39"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024263_0_1_1"/>
    <dbReference type="InParanoid" id="F9X1Z2"/>
    <dbReference type="OMA" id="FKAGANW"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="410" mass="45724" checksum="99E8DCB332D996B1" modified="2011-10-19" version="1">MSMQDGSAPQGPPYLPPIAFIGGVPTLETDVPICALLLLFYAGAAIGHNVTYQLNRKKGHKFIPSIVLFGFCMSRILTCALRMGWALHPDNVSLIIAANVFVQAGILIVWVVNIIFTQRIIRAVRPKIGWHPVASLFPKVLFALAGISLALVVSWTISSYYTLDEQFQTIARDVQRAAITYLLVFTLVPIVTLPLAFSKGKGAQEFGRGSMGSKMVVVWVSSHVCLLEVVFRVATSWAPGRPADNPAWYHSRAWFYVCDFALEIIVIYWLLLARVDQRFHVPDGSSKRKHYHAPAEAHGDESDAEAGDMFDEGRDYWAYHQSGTLTGDHWRSNHSGVFPGRRRRSRNSGTIVSQRDRRSPHIGRVTTREYTSPAGDDRRKSGHSEITTTHWLQVPETAPTEVSSVSLGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X217</accession>
    <name>F9X217_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GliJ</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_84379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854719.1">
        <property type="nucleotide sequence ID" value="XM_003854671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X217"/>
    <dbReference type="MEROPS" id="M19.013"/>
    <dbReference type="GeneID" id="13395888"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84379"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.66"/>
    <dbReference type="InParanoid" id="F9X217"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="397" mass="43817" checksum="56C12AF3BE204BE2" modified="2011-10-19" version="1">MEPVEEQDVLQQARQLLREAPLIDGHNDFAYILRGWFAGTPQIQEQGRYRSIPIGQTDVERVKKSGLGGQFWSAFVPAPPEEHEPHLRAFLHTVQQIDLIAQVIDSAPDTFEFAYSAKSITRIFGTGKIACLVGIEGLHQIGGSMAALRQLHRLGVRYATLCHDTNNEFADSATAQRARHGGLSPRGSQAIREMNRIGMMIDLSHTSDDCQRQVLALSQSPVIFSHSSCYALRAHPRNVSDDVLALLKKNNGLIMITFLRELSGIDELSSQTASCSTVVDHIEYAARCTGWEHVGVGSDFDGMLEGPTGLDDVTAFPCLIAEMLRRDISRDQMQMVMGGNLLRVLKDVEDHATRQRNDGASVLQDTVLPVWTEAQREMLLAKGAERGLVTSDTSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X262</accession>
    <name>F9X262_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_107924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855697.1">
        <property type="nucleotide sequence ID" value="XM_003855649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X262"/>
    <dbReference type="GeneID" id="13403637"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107924"/>
    <dbReference type="eggNOG" id="ENOG502TI5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1908334_0_0_1"/>
    <dbReference type="InParanoid" id="F9X262"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP90673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="15296" checksum="D9C0D88485560490" modified="2011-10-19" version="1">MEESIGSHRVHDVYADVTEQERAAYPEFALYDAQRELQRRGDDTRSMSGGWDLAKYMNLAMLRKIRAMISDKKWFVFIDTDTFIDWDNLFTLLEHLDPDKRMYLGSPVWLPELQFAHGGSAYALSSGALGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J3</accession>
    <name>F9X2J3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_98948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854724.1">
        <property type="nucleotide sequence ID" value="XM_003854676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2J3"/>
    <dbReference type="FunCoup" id="F9X2J3">
        <property type="interactions" value="1267"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2J3"/>
    <dbReference type="GeneID" id="13395893"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98948"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.83"/>
    <dbReference type="eggNOG" id="KOG1107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2J3"/>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="890" mass="99586" checksum="D44DCED33B570E01" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2N0</accession>
    <name>F9X2N0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_90406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854742.1">
        <property type="nucleotide sequence ID" value="XM_003854694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2N0"/>
    <dbReference type="STRING" id="336722.F9X2N0"/>
    <dbReference type="GeneID" id="13403713"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90406"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2N0"/>
    <dbReference type="OMA" id="VWYRWKL"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </evidence>
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        </source>
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            <dbReference type="EMBL" id="EGP89718.1"/>
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        </source>
    </evidence>
    <sequence length="776" mass="85768" checksum="0D2F1C24826F1D56" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2P9</accession>
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            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        <location>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="481" mass="52280" checksum="27AD14E839767812" modified="2011-10-19" version="1">MDVEEEPALYSKRSIFFMVLFSGLAIGSDAYNSALMGQLGLLLTVIYPDTLSVAMQSQLTNAFIIGLILGMLAFGFISDRLGRRSGAVLTTLFLSVGIVMSAASHGTSDNGLFWMLTISRGIAGFGAGGEYPVSGAGTAESTDDSPRARKHRGFIFAMVSDVSASFGFIFSGLVPLLLLLCFQEEEKQYGKVWRIAFALGVIPPISIFWFRYRLAMSSAERRSSARHAILPYHLAVKRYWRPLLGSALAWFIYNYIAYPFGLFSSSILASVNAGDSLVKSYGWGTLINCFYLPGGFIGGYLSDRIGRRRTMALGFGLQACLGFIIGGCFPQIQDRTALFIILYGLFLTLGEIGPGACIVATSSEFFPTSIRGQMMGLCSAIGKAGAAIGTSVFKPILASYGDNVLRGNQAVFLIGSGFAVLGMLVAWFFIPSQPANLVQEDDQWKLYLREAGYDIHFGDDKTKDPPKVQFDGVRQKTMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3F2</accession>
    <name>F9X3F2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">qa-2</name>
        <name evidence="3" type="synonym">qutE</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_36803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003854765.1">
        <property type="nucleotide sequence ID" value="XM_003854717.1"/>
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    <dbReference type="STRING" id="336722.F9X3F2"/>
    <dbReference type="GeneID" id="13403693"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36803"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.167"/>
    <dbReference type="eggNOG" id="ENOG502S1A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3F2"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF5">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="148" mass="15998" checksum="BE02BD3766497805" modified="2011-10-19" version="1">MPGSILLVNGPNLNLLGLREPHIYGSTTLDDVQTAAVKQAEGLGITLSHFQSNHEGAIIDRLHEARGKIDYVIVNPGGLTHTSVALRDALLGVELPFIEIHVSNVHTREAFRHHSYLSDKAIAVICGLGVFGYTAAIDFLALRLKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3R6</accession>
    <name>F9X3R6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_37570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854970.1">
        <property type="nucleotide sequence ID" value="XM_003854922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3R6"/>
    <dbReference type="GeneID" id="13403460"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37570"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.643"/>
    <dbReference type="eggNOG" id="ENOG502SUUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123909_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3R6"/>
    <dbReference type="OMA" id="GYPVNWP"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="171" mass="18756" checksum="BCE792B079441CA1" modified="2011-10-19" version="1">MSTIRTRSASDLDACVEVLKAVYDNDGYPVQGVEEAKSFLSGDSIRQAWICEQDDQIVGHVAASSKTPESDVSVALWTQDHADDPSDIAVLERLFVDPYSRGLGVAGKLIDAAVAWSHEKDMRLVLFALEKDRVAAKLYERLGWSHFGTTTYHYDNGKTMAALCFVSPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3W2</accession>
    <name>F9X3W2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855073.1">
        <property type="nucleotide sequence ID" value="XM_003855025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3W2"/>
    <dbReference type="STRING" id="336722.F9X3W2"/>
    <dbReference type="GeneID" id="13400962"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108196"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.858"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_2_0_1"/>
    <dbReference type="InParanoid" id="F9X3W2"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11706" checksum="14AE5DB0D0E9AE23" modified="2011-10-19" version="1">MSEATPRITAPYLGEFSHRTVRVVGKVSQLRGMEATIDSGGDIIVHLNMDSHLHVGNTFEFIGKVGQDLSLKVMASTDMGPNVDFSAYEALVDATHRYSEIFYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3W5</accession>
    <name>F9X3W5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_68749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855413.1">
        <property type="nucleotide sequence ID" value="XM_003855365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3W5"/>
    <dbReference type="STRING" id="336722.F9X3W5"/>
    <dbReference type="GeneID" id="13400960"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68749"/>
    <dbReference type="eggNOG" id="ENOG502SD1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096859_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3W5"/>
    <dbReference type="OMA" id="YETNKGA"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17447" checksum="7FD8C419FCD28D4A" modified="2011-10-19" version="1">MPVLSSSEEWQRQSSLLLQARPTTTRITTKYNIPNLDSPKYQKTKKRKRETDGEDKDAPAAPRVPRATLTLKTYDPESGVVLKFKTDRAAEVGRLIGSLGRVGRYMAALPEKEEGLPAQDTVPEDVPAIEQAADSTLPTSDSKPQSGAGGGKKKKNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X435</accession>
    <name>F9X435_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CIT1</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_108333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855181.1">
        <property type="nucleotide sequence ID" value="XM_003855133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X435"/>
    <dbReference type="STRING" id="336722.F9X435"/>
    <dbReference type="GeneID" id="13400533"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108333"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1123"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_0_1_1"/>
    <dbReference type="InParanoid" id="F9X435"/>
    <dbReference type="OMA" id="SGVMAHW"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="495" mass="54390" checksum="414B94A0667BF421" modified="2011-10-19" version="1">MARQPESTVLKTWRAVAGLSTSVQRWKKRLDKSLAMAALALFRATGATSLGASSGTLSVTDNRTNRRYTIPIMHNSVRATDFRQIAAAGRGADPVDQVESGLRIIDRGFLNTACMESNITLIDGQRAYIQYRDHSIEHLFDNNDYEEVVHLLIWGHLPSTQEKTKLRKAFAAAATPPRPVVEVVQAFPRDALTGTILLAGLAAWAACDPGTQSVHQENRPKYLGNIAEVDAAIIRTTQAMATTIALAYCHKRGKPFTQPEREGTFIGNVLTMMGFTDNMGKPIAEIEATFARLWILYADHEMTNSTAAFLHAASTLSDPLSCAVSGIVSAYGPLHGGAIDQAYKGFQTIGTPENVPILIADVKAKKQRLFGYGHRIYKKTDPRAKLIRSMIDEHMPKVKDNPLLRVALEVDRVANEDDYFTSRNLKANADLYGCFLYTALGFETDIIVALASLSRTPGVMAHWRESMSQTPLLWRPLQVFTGSIASAARSDVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4B1</accession>
    <name>F9X4B1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_68179</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854890.1">
        <property type="nucleotide sequence ID" value="XM_003854842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4B1"/>
    <dbReference type="FunCoup" id="F9X4B1">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4B1"/>
    <dbReference type="GeneID" id="13399379"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68179"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.440"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="InParanoid" id="F9X4B1"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="693"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1072"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1138"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131167" checksum="09CF9B0C8577D9A5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4B6</accession>
    <name>F9X4B6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_99074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854892.1">
        <property type="nucleotide sequence ID" value="XM_003854844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4B6"/>
    <dbReference type="FunCoup" id="F9X4B6">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4B6"/>
    <dbReference type="GeneID" id="13403560"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99074"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.446"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4B6"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="241" mass="26815" checksum="B2493991CA304762" modified="2011-10-19" version="1">MPKSKRSRVVHTSVVQKKPSKEKALALFEAVQHAADSYAHIFVFDVENMRNTYLKDVRQQFSDSRIFFGKTKVMAKALGQTRETEHAPGLWKLNQYLKGSVGLLCTNRAPAEVLQYFEGYVEVDFARAGTEASRTFTIPAGVVYSRGGEEAIEDDVALPHSLEVTVRKWGMPTRLEKGKVMLDQEHTVCQEGKELNSHQTALLKLFGVATAEFKVEVQAYWSAATQDVTEVAKAAGAMEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4I2</accession>
    <name>F9X4I2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854996.1">
        <property type="nucleotide sequence ID" value="XM_003854948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4I2"/>
    <dbReference type="GeneID" id="13403436"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37101"/>
    <dbReference type="eggNOG" id="ENOG502R8TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="InParanoid" id="F9X4I2"/>
    <dbReference type="OMA" id="PAKYHTH"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48281" checksum="2D4FA69B40A104BC" modified="2011-10-19" version="1">MKNQELASAFRSHLPDLTSPRFTTSAKQSPYEYTEAFQQNRAPPWLYNLTETWKELLKEPFKGVTVDGSVRDGLFKTDDQEVPVGKICEAANNVLSKLTLQQKTKVQNPMNSEKWRCWSNPEFLLRPFGLRLEELPEEIIQTILGVLQATFSVEGYQKAVSAMRINHFLGEVCEVPRILNQYSYNFLIFGEPSPTKAWGWSMYGHHLCLSVFLQGSQIVISPTFTGAEPNIIDKGPWAGTAILHKEGDLGLKLMQSLPKDAQNSAQIFEKMKDPGMLQSGDLKVDRWNQDDQRHLCGAFRDNRVVPYEGIKVSSMAEDQQNTILAIAEEFLLYHPDKARQLRKQQIQEYFDETYFSWIGGYGDEDPFYYRIQSPVIIFEFDHHSGVFLSNTEPAKFHTHTIVRTPNAGDYGQSLREPRDCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4J8</accession>
    <name>F9X4J8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MgGlgB1</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_68779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855404.1">
        <property type="nucleotide sequence ID" value="XM_003855356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4J8"/>
    <dbReference type="FunCoup" id="F9X4J8">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4J8"/>
    <dbReference type="GeneID" id="13400951"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68779"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.878"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="InParanoid" id="F9X4J8"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
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        <property type="entry name" value="GH13_cat_dom"/>
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    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="219"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="711" mass="81535" checksum="261BD94FDC1306BE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X516</accession>
    <name>F9X516_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_56708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X516"/>
    <dbReference type="FunCoup" id="F9X516">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X516"/>
    <dbReference type="GeneID" id="13395622"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56708"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.500"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="InParanoid" id="F9X516"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="755" mass="83911" checksum="3EB8FDB72A1C7AF8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5E4</accession>
    <name>F9X5E4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CYP-67</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_23237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853624.1">
        <property type="nucleotide sequence ID" value="XM_003853576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5E4"/>
    <dbReference type="STRING" id="336722.F9X5E4"/>
    <dbReference type="GeneID" id="13400909"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23237"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="F9X5E4"/>
    <dbReference type="OMA" id="MARFDHW"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="446" mass="49708" checksum="A82743BA22A529A2" modified="2011-10-19" version="1" fragment="single">LLLTLLRRYLALRTIPGPFLASLTDLWLALRIWRGEYFVDIVSELHKAYGPVVRTGPNRVSFASAEAIPEIYGTSKVYSKAASYQPMTLLAKGQEIPTIVTLRDEKRVTEIKRHVSNGFAQSTWLKQEHQIDGTIDILLDQLRKRAGTVISLNKWLSFWGFDTLTMLAFSDMQGHMEAGAEVDKTSAGAKARFDHWRAWALLPSLEALLYKNRFVQSFQKPSSGLAKLAMKRIEERKASTDEDAPDQDLLGRYLAASKKAPDMIGSRDVMALTISTIHAGSETVAHTSSFALAYALDKMEIFQKLEQEILTAGIRSSPAAYADVEKLPYLDAIIREALRFSASPNTMERTIPPAGAEICGVALPGGTDVSVAKPCTSRDESIFGPHADQFDPERWLHADEQQRREMEHATLAFSFGRRVCIGQHLARIEMKKLIATVVREFKVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5M5</accession>
    <name>F9X5M5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L37ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_85212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854405.1">
        <property type="nucleotide sequence ID" value="XM_003854357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5M5"/>
    <dbReference type="FunCoup" id="F9X5M5">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5M5"/>
    <dbReference type="GeneID" id="13404183"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85212"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.549"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="F9X5M5"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10122" checksum="2C291513761A2F47" modified="2011-10-19" version="1">MTKRTKKVGITGKYGTRYGASLRKQVKKIEISQHARYTCTFCGKVSVKRNATGIWDCKSCHKTIAGGAYVVSTPAAAATRSTIRRLREIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X617</accession>
    <name>F9X617_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_38212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853656.1">
        <property type="nucleotide sequence ID" value="XM_003853608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X617"/>
    <dbReference type="GeneID" id="13395821"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38212"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_0_1"/>
    <dbReference type="InParanoid" id="F9X617"/>
    <dbReference type="OMA" id="ERYAYHM"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="34"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="280" mass="30681" checksum="A96F37302D4226AB" modified="2011-10-19" version="1" fragment="single">PVPTASSGKRGLSFNDPKFTNLFSAISCTLNPVGRSRTSWAYNWFSAPCDNFNHASLCSVPFNPYLEFIPMLWSNDRDLQNVWNSNVQAAAARGWKTILAFNEPDIAHSGGSGMSIADAVTSWKQYIQPLKAQGFRLGSPAVTNAQGLNMGNDWQVKFLDQTPGKGGCIGCTVDFLAVHWYGGPTDFDSFFNHVAYSWSVVGGQRMPVWITEFGITGGTDAQVENFLRVVIDAFENQPYWSFVERYAWFTAGNSSPTSGPLVAANGTSLSRAGQVYENQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X665</accession>
    <name>F9X665_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_27084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854516.1">
        <property type="nucleotide sequence ID" value="XM_003854468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X665"/>
    <dbReference type="FunCoup" id="F9X665">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X665"/>
    <dbReference type="GeneID" id="13404086"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27084"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018149_1_2_1"/>
    <dbReference type="InParanoid" id="F9X665"/>
    <dbReference type="OMA" id="HEEYIQH"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="180" mass="20401" checksum="1312118A2EBE5F48" modified="2011-10-19" version="1" fragment="single">ALEHFIYMPVSQDMISYLAHKASQVIRCEGSTPSSRNMPPTPPTTPPHNQQFEPALPSLEEFITALVERSHVQVPTLMSSLVYLSRLQARLPPVAKGMKCTSHRIFLASLILAAKNLNDSSPKNKHWARYTSVRGYDSFGFSLTEVNLMEKQLLNLLDWDLRVEEADLYLHLDPFLAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6Z5</accession>
    <name>F9X6Z5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_91858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853928.1">
        <property type="nucleotide sequence ID" value="XM_003853880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6Z5"/>
    <dbReference type="FunCoup" id="F9X6Z5">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6Z5"/>
    <dbReference type="GeneID" id="13404267"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91858"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="F9X6Z5"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="17854" checksum="D8F18883C43E1A31" modified="2011-10-19" version="1">MNGLSTRARDAVSGACGVVEGNDDLSLPKATVQKIINEVLATNPSLNTDGQQGGMAFAKETRDVLIDCCVEFITMLSSEANEIAEKDAKKTIACEHITKALQELDFGEYVPELLKQADSFKSAAAHREKKQTKIEQSGMTSDELIRAQEELFKSAGEKYNAAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X727</accession>
    <name>F9X727_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_70442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X727"/>
    <dbReference type="FunCoup" id="F9X727">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X727"/>
    <dbReference type="GeneID" id="13404541"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70442"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="InParanoid" id="F9X727"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="310" mass="34451" checksum="FA3CCCC53DB60F05" modified="2011-10-19" version="1">MPSTRKRKGSPSLEETAESTKRRFAEGSEAEAATEETSQPSATTTSQPQKTSPHPSSTTSQAADDRAARFAALRARATSSKKQNLNATKSEAAHAAIDPTQLTSLHRKKDIATHKLLKADVEASGGDFERQRAWDWTIEESEKWDERLAEKARKRDGNKFASYGAEAGSVYERQVRQNLEGRLSAYEQNKVDAIERAVASGGLELVETPEGELIAVDRDGSFLSTADSATAGYAEKRPSKQAVDRLVEDIKKAEEVRQKKRKERGRADENDSGDVTYINEKNKQFNMKLARFYNKYTADIRESFERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7B7</accession>
    <name>F9X7B7_ZYMTI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853950.1">
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    <dbReference type="AlphaFoldDB" id="F9X7B7"/>
    <dbReference type="STRING" id="336722.F9X7B7"/>
    <dbReference type="GeneID" id="13404288"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70129"/>
    <dbReference type="eggNOG" id="ENOG502S31Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_2_0_1"/>
    <dbReference type="InParanoid" id="F9X7B7"/>
    <dbReference type="OMA" id="HWATSEM"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390191" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="331" mass="36321" checksum="7B336F35FF2EF534" modified="2011-10-19" version="1">MALTTSIITVLLATTCLAGSNIPQKRQFPGGCTSPVQRRSWSSLSSDEKLAYINADKCLMNTPAQHGIPGAVSVWDEIQYAHIRNMNWIHGVGQFLLWHRYYVTVYERLMQQHCGWTGGVPYWRISTDADNILASPIWDTTTGLGGNGAFGNGCITDGPFVNTTLRFHDDGTAGEPYCITRNINAETYRGSVQGEIDSCMQSQDFAQAHACYENTVHASAHQGTGGMADALTAPGDPIFFLHHTNLDRLFWEWQQTNPAHLTDISGSNTPSDDFNRGNNWAPPGPEFTQFSGDNGPMTTMGHVLWMIGILPNVTIGDVMDLRGATICAEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7G8</accession>
    <name>F9X7G8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854172.1">
        <property type="nucleotide sequence ID" value="XM_003854124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7G8"/>
    <dbReference type="GeneID" id="13404512"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92174"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1090"/>
    <dbReference type="eggNOG" id="ENOG502SFRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219671_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7G8"/>
    <dbReference type="OMA" id="LARNQPC"/>
    <dbReference type="OrthoDB" id="5399926at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="243" mass="26630" checksum="BBBBE980D7B935FE" modified="2011-10-19" version="1">MSDSPLKSYLRDGYGPRAVDAGRDAGRSGGNRQKEAEDSDRRRSKQPSSRKTSKSESSHRRKTSSTSTAPSTVREPTSDRPIFELDVIGQPPQNIVYGTSVETSVLLSLRLPSPELAARYANADTSRLLAIVSLVEESRSGERKPMESGTLTSQQMSDSVHPIPEEYAETLARSQPDRAHLGYFTFPALLIRQPGLFRLRVTLIQVCPSASGGGSTVAAVDSESIKVERRHTGSSSQRRQQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7P0</accession>
    <name>F9X7P0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_22584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853699.1">
        <property type="nucleotide sequence ID" value="XM_003853651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7P0"/>
    <dbReference type="FunCoup" id="F9X7P0">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="13395747"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22584"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017517_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7P0"/>
    <dbReference type="OMA" id="NPQCQIP"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="490" mass="53020" checksum="BD19ED334CD31217" modified="2011-10-19" version="1" fragment="single">EFAGLPWYKRPSLFWMVGPFFVLAFAFGGIIAPKINLIMDLVCRQYISDQMSLNPNLALLPVDFRGGTNNQCRIPEVSSRASILTLWASVISGILSAIASPKLGALSDRYGRRIVLVITSCGTIAGEIIFIFAAIYPETFPIPLILVSYALDGLTGSFILAMSISHAYATDCTPPASRNVAFGYFHGALFTALAIGPIFAGYIVKLTGSIVSIFYMLTSVHVAFVFFLLFIIPESLSEARQKQARELHAAHVAQQGEQGDWINRIRSLNVLAPLKTLYPTGPGTSPALRRNLFFLAAVDTVCFGVAMGSMTVIVIYVKQQFGWETFESARFMTAVNSSRVVCLLIILPLVTRMVRGKPLSHEDAEKAKNTGCDNFDLIIMRLAIFLDMVGYIGYSLSSTGGPFTLSGVIAAFGGIGSPTLQAALTKHVPVERTGQLLGAMSLLHCLARVVAPAVFNAIFSATAKGFPQAVFVCLAATFGLAWMGSWMIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X823</accession>
    <name>F9X823_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_92212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854148.1">
        <property type="nucleotide sequence ID" value="XM_003854100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X823"/>
    <dbReference type="FunCoup" id="F9X823">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X823"/>
    <dbReference type="GeneID" id="13404479"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92212"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1134"/>
    <dbReference type="eggNOG" id="KOG0346">
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            <end position="512"/>
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</entry>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
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                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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            <end position="154"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
    <sequence length="218" mass="23665" checksum="027ECD4A619126AA" modified="2011-10-19" version="1">MPPPVHRPIEPTSDQPTSPHAVVNALPLRVSAARRKMCERDTPVPHVVLRGVAREGGSRAPFPPPIAAVAHIRTSMIPSMMMMQVTAIPHTPQFPGPFRPDASRLAEILRILEIRTAWPCIAPMGRHPKRGDSKAVGATGSGRTDLGQWPEQDSVSAPIPLGRRLAAGCESISTAIEASVGGRRRWAFAFSSPDPEFATEHYCVRGHVMDNADDQSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <dbReference type="eggNOG" id="KOG2817">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="44408" checksum="BECFC768C0210314" modified="2011-10-19" version="1">MDALIAAHEQQEKKGNLSAAITDVQKLIDLLQNARDAVADNPDMAPLHLAKLQKPVKQSFTNLEDDLKEVNKGLNAYRKALDNKFKNAVLPTASNDALASQPQLINRAIAMHLLREGKFDVAKTFVREVQENPVRSGVVDGDTQMEGTAEGTAEGTDEEMPDSQQQLPPEDGIEQLVGTWAAQNSSALEHRGSNLEFELSRLKFVELYTSPQTTSPDDPFSGPLRALEYARTTFPAFSTRYRHETSLLLGSLAFSPSLQTSPYTTFFQTPSLYTSASESFTREFCGLLGLSSLSPLYTAVTAGGIALPILTKVERVLEASRGQWTSVNELPVETPLPDGFAFHQIFVCPVSKEQGTDANPPMMLPCGHVIARESLEAHSKGKARMKCPYCPQECHPREAKRVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8Y6</accession>
    <name>F9X8Y6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853472.1">
        <property type="nucleotide sequence ID" value="XM_003853424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8Y6"/>
    <dbReference type="GeneID" id="13397264"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92472"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.318"/>
    <dbReference type="HOGENOM" id="CLU_2199082_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8Y6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="12382" checksum="FF70C10F39E4FB5E" modified="2011-10-19" version="1">MKRMGFWHALSIFLPHIRTQTEEFLFRISASSFHLISRNLTALASETYDRYLPAHHHRCKAQVCPATSYPNPPPDNKSDRLAFRQPRMLLQFLAILAAAMALVSTETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X940</accession>
    <name>F9X940_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MgXBX3</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_71284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853364.1">
        <property type="nucleotide sequence ID" value="XM_003853316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X940"/>
    <dbReference type="SMR" id="F9X940"/>
    <dbReference type="STRING" id="336722.F9X940"/>
    <dbReference type="GeneID" id="13399264"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71284"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.547"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="F9X940"/>
    <dbReference type="OMA" id="WGFKGHV"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391199" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="785" mass="85737" checksum="119EC24A3B59024C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9N4</accession>
    <name>F9X9N4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_109196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853299.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X9N4"/>
    <dbReference type="GeneID" id="13400166"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109196"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9N4"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="8">
        <location>
            <begin position="338"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
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            <end position="20"/>
        </location>
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            <end position="59"/>
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    </feature>
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        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="576" mass="63513" checksum="6B1108D7069AB435" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9P1</accession>
    <name>F9X9P1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853342.1">
        <property type="nucleotide sequence ID" value="XM_003853294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9P1"/>
    <dbReference type="GeneID" id="13400010"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104234"/>
    <dbReference type="HOGENOM" id="CLU_1880493_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9P1"/>
    <dbReference type="OMA" id="TTMTVFR"/>
    <dbReference type="OrthoDB" id="4778512at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="136" mass="13908" checksum="F9AB8602F7A3C5B6" modified="2011-10-19" version="1" fragment="single">STDAFYNIAIRSDTMRFFDLSATALAAAAMLSGVSADAPPSYVATTLDVEPIVSGSATATTTYYVTRTVLRVVTTVTATSNGTSSAYTTIEASTEAVATVEPSSTVEPSSTVEPSSTVEPSSTVKPSSTVEPSPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAG4</accession>
    <name>F9XAG4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
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        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_72261</name>
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    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852582.1">
        <property type="nucleotide sequence ID" value="XM_003852534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAG4"/>
    <dbReference type="FunCoup" id="F9XAG4">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAG4"/>
    <dbReference type="GeneID" id="13394011"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72261"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.473"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="F9XAG4"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="632" mass="69195" checksum="85A5F1C7B91F968F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAM3</accession>
    <name>F9XAM3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_22604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852048.1">
        <property type="nucleotide sequence ID" value="XM_003852000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAM3"/>
    <dbReference type="GeneID" id="13397092"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22604"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="InParanoid" id="F9XAM3"/>
    <dbReference type="OMA" id="FTWLWQF"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="542" mass="57659" checksum="4F095E35B18E3173" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAP2</accession>
    <name>F9XAP2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_71742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 9"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852762.1">
        <property type="nucleotide sequence ID" value="XM_003852714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAP2"/>
    <dbReference type="FunCoup" id="F9XAP2">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAP2"/>
    <dbReference type="GeneID" id="13393834"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71742"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.84"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAP2"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000009">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="457" mass="51516" checksum="9F002D3B7CDC118F" modified="2011-10-19" version="1">MANTANDTPEGIFSLLDTDLYKLTMQCAVLKYFPDTHVRYKFTNRTPQMKFTRQAFNWLHAQIRKLEIVEVTKEEIEWLRRTCKYLTPEYLDYLQTFRLRPSEQVKASFMPDSDATSDSVTGEVSLAISGIWVETILYEIPLLALTSEAYFKFVDKDWNHNGQVAKAKEKAEKLFEAGCVFSEFGSRRRRDYKTHEMVIQGILQAQEEAKNNGKNWKGKLTGTSNVHLAMKHNTTPSGTVAHEWFMGIAAITQDYANANEKAMEYWIGTFGPGVLGIALTDTFGTPSFLKAFAKPAPSSDSSRTSSASPSPTYAQVFAGVRQDSGDPLEYVQMIRQFYSSQNITSPKTVVFSDSLNIDRCIKYKQATEAVGLTPAFGVGTFFTNDFWHLSKDEKSVPLNIVIKLSEANGNDAIKLSDDKGKNMGDEGLMRSVKEQVGYTEKSWRDGDEAHRWDKNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB52</accession>
    <name>F9XB52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MgSGA1</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_42503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852428.1">
        <property type="nucleotide sequence ID" value="XM_003852380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB52"/>
    <dbReference type="FunCoup" id="F9XB52">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB52"/>
    <dbReference type="GeneID" id="13394161"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42503"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.803"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_1_0_1"/>
    <dbReference type="InParanoid" id="F9XB52"/>
    <dbReference type="OMA" id="NRKYTVP"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="12">
        <location>
            <begin position="503"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="609" mass="64700" checksum="0A7C410C7E005822" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBW8</accession>
    <name>F9XBW8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">6PGL</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_109450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852671.1">
        <property type="nucleotide sequence ID" value="XM_003852623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBW8"/>
    <dbReference type="FunCoup" id="F9XBW8">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBW8"/>
    <dbReference type="GeneID" id="13393934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109450"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.296"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="F9XBW8"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="28688" checksum="992BCDC738110ACB" modified="2011-10-19" version="1">MPGHPNLYSFPTTTDLAPHLRKYILDAQNDALARHTTFRLAVSGGSLPSTLSAALLAPAKSPSDTPQFSQWEIFYADERCVPLTHEDSNHRLVQSDLIDKIPEELGKPKVHTIDDSDLEDVQGVADHYEQLLVSSFASRDSVKLPLFDLILLGCGPDGHTCSLFPDHALLRETSAWVLPISDSPKPPPKRITLSLPVVCHAAKVAFVATGKGKREVLKKIFDSEEGRVLPCGLVNEGAGEKCSWFCDGEAVEGVNFPRRGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBZ8</accession>
    <name>F9XBZ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ERG28, endoplasmic reticulum membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ERG28</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_86065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86065"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.326"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Erg28"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
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            <end position="34"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="105"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87629.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15182" checksum="6EA7FF3A59ECB180" modified="2011-10-19" version="1">MSQVSSYLPPGEGFLPKWLLFIAVVALGNSIQSYTSLRGTREVYAGNNPSAVTPLSARTFGTWTGLSSIIRLYAAYNISNPVVYQLALWTYGIAFAHFFSEWLIFGTAKWGRGLGGPVFVSTVTTVWMVAQWGWYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC04</accession>
    <name>F9XC04_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HDA2403</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_72058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="F9XC04"/>
    <dbReference type="STRING" id="336722.F9XC04"/>
    <dbReference type="GeneID" id="13393950"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72058"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.333"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XC04"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
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        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1202" mass="128817" checksum="58B6F8F439BC71C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC71</accession>
    <name>F9XC71_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_104491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852180.1">
        <property type="nucleotide sequence ID" value="XM_003852132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC71"/>
    <dbReference type="SMR" id="F9XC71"/>
    <dbReference type="FunCoup" id="F9XC71">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC71"/>
    <dbReference type="GeneID" id="13396966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104491"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.347"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="F9XC71"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="38194" checksum="08A24644FE0FD840" modified="2011-10-19" version="1">MHSKVVIIGSGPAGHTAAIYAARADLKPVLYEGFMALGIAAGGQLTTTDEVENFPGFKMIKGTTLMDNMRAQSEECGTEIVSQTVGKVDLSSRPFKFWLNPMGDDDTLKEETHTADSIIIATGAKARRLDLPGEEKFWGNGVSACAVCDGSLPIFREKPLVVIGGGDSAVEESLYLTKKASKVTVLVRKDFLRASKTNARRLANHEKVEIRYNTQGVEIKGEAGDRGLMQSMVIKNNKTGETEEIPANGLFYAVGHDPATHLFNGQVKMDEDGYIITTPGTTETNIPGVFAAGDVQDKKYRQAVTSAGSGCMAALEAEKFLAENEDVPVENGVEADKGAKKGDSSEAPEYRSNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDJ4</accession>
    <name>F9XDJ4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851530.1">
        <property type="nucleotide sequence ID" value="XM_003851482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDJ4"/>
    <dbReference type="GeneID" id="13401589"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104884"/>
    <dbReference type="HOGENOM" id="CLU_2485061_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDJ4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="87" mass="8922" checksum="EDF3746DDDDBFF92" modified="2011-10-19" version="1">MASNATISRAQWAEGSPTEKAGPFVKDRLHALISATSSERSTAKDGNPEMTAASSSRPSHSGSQQGHVLPSGSYARLLQGVLIDGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDL8</accession>
    <name>F9XDL8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_19346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851805.1">
        <property type="nucleotide sequence ID" value="XM_003851757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDL8"/>
    <dbReference type="GeneID" id="13402169"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19346"/>
    <dbReference type="eggNOG" id="ENOG502RB4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183427_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDL8"/>
    <dbReference type="OMA" id="MYRALIG"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="8983" checksum="61950B2B961470FC" modified="2011-10-19" version="1" fragment="single">RRVQSVLLVIFIDNFGLYRNIYRALTGFYMLFGSLSNKERNRRANCIPLTLGLHGSNIEEIIEAIGGALSLLNRSAEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE21</accession>
    <name>F9XE21_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_43486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851322.1">
        <property type="nucleotide sequence ID" value="XM_003851274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE21"/>
    <dbReference type="STRING" id="336722.F9XE21"/>
    <dbReference type="GeneID" id="13401244"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43486"/>
    <dbReference type="eggNOG" id="ENOG502QQ2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="InParanoid" id="F9XE21"/>
    <dbReference type="OMA" id="FDPHFHM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="294" mass="32631" checksum="8FE46850A6FE6FE8" modified="2011-10-19" version="1">MLTLNPALTPVHFFSHGSTMMLGEESTSATYWKACGDAALANNIKGVIMMGAHWDSTGENSIEVATNPTPAKSPVAYVHPSKYVDYRLTPDLPTASRVIDLLNTAGFNAKGNPTFDWIHDTYLILIRMFPAGCPPTTIISMNARFDPHLHMRVGSAVRSLREEGYLLIGTGGAVHNLYRNRWGPMLKYRDSFAQETPPEGWALEFRQSVEDCFRNCRGPALRRAVTRLMKHPMFRGAHATDDHFMAACFVAGAAGDWEDEKEMEGRLGAETWELTNMCNSQFTIGSWGGKEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE77</accession>
    <name>F9XE77_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_44183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851722.1">
        <property type="nucleotide sequence ID" value="XM_003851674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE77"/>
    <dbReference type="STRING" id="336722.F9XE77"/>
    <dbReference type="GeneID" id="13402010"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44183"/>
    <dbReference type="eggNOG" id="ENOG502QRYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553311_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE77"/>
    <dbReference type="OMA" id="VTMTMIW"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55890" checksum="1FCD89BFFA4FF629" modified="2011-10-19" version="1">MHINDLESRLEYLVAENRALQEARSNNDVTMGEGGGLQDELHARDLQLQEKDAEINQIKAMLQPLQDEIARLTEMNNGLTEANRNLVDDTNGRYATLQAEHAEAHEQWQSTSRDLQAMQQEHGRITSGMKDILEAEIASALADKNSEILRLREQLDIATEQIRALQVQIQSSNSSDFLVQRDEDYFDGSCQKLCQHVQQWVLRFSKLSDNRVCRLSTDLNDDKIEARLDNAVLDGSDVDKLLGDRIRRRDVFMSVVMTMVWEYIFTRYLFGMDREQRQKLKTLEKLLSDVGPPRAVAHWRATTLTLLSKRPNFAEQCRMDTEAVTHEIFGVLCALLPPPSTSEQQLLTSLQRVIGIAVDLAIEMRTQRAEYIMLPPLQPEYDTNGDLVRKVHFNASLMNERSGFFSSNEDLAAENAVVKIVLFPLVVKKGDDIGEGDEEIVVCPAQVLVQNDGGKGRKVVRVQSGAIQMDVDEGRRSGMSRRSMLSEGMGSEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE84</accession>
    <name>F9XE84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_73494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851716.1">
        <property type="nucleotide sequence ID" value="XM_003851668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE84"/>
    <dbReference type="GeneID" id="13402004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73494"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.628"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="F9XE84"/>
    <dbReference type="OMA" id="QVNDEDW"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="254" mass="27467" checksum="F72F9B6B0A8EC234" modified="2011-10-19" version="1">MSVQKVALITAGTAGLGAQVARVLAPDFRVAINYANNTERANTLIKELETIPNTSNSASTSPRFAAFQADVGSRPALQDLVHQTVSTFGRIDLVVSNAGWTRITNFANLEEGMIDEDWDRCFLYNVKAHLWLLHAAKAELERTEGAFITTASIAGVKPSGSSLPYAVTKAAAIHLSKSLAMICSPKIRVNSVSPGLLLTEWGMKFPEEKREAARERTALKRLATVEDCADQIRALALNRSMTGQNINIDGGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XED9</accession>
    <name>F9XED9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_43113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851973.1">
        <property type="nucleotide sequence ID" value="XM_003851925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XED9"/>
    <dbReference type="FunCoup" id="F9XED9">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XED9"/>
    <dbReference type="GeneID" id="13401242"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43113"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="InParanoid" id="F9XED9"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="449" mass="49107" checksum="C18287678F90E1D7" modified="2011-10-19" version="1">MAEAIKSITSRILDLPPSCIAFVPTHPRLFVVGTYYLHPREEQETLPSESKVDPENDAGQSSNDADDEEERDEDDEVQRKDPQPQKRSGSLILFDLDPETSQVTLLQTLPISSAVLDIQWRPSLSSSTVSSPPLLATATSTGSVHFHTLASSSSEAPAELQPISTHQLTDSTAELCLYFAWHPTRPDIFGATFNDGNAKVYSTSYTSSPAPRNELTIHHIATLPSHSLETWFLSFSPTPASDNSSSVYTGGDDGLLLVSSLPLSHEPVLEAINLHTRIQDRKSHQAGVTSILPLPASFSPTASQRRELVLTGSYDDHIRLLSLPVPGQTGRVQVLAEMDLGGGVWRLSFLSSSTTKDGEGEDVVILASCMHAGTRIVRLHRPRQGGVGVGEEGDWEFEVLARFEEHQSMNYGSDVQPVVGVGDGKGRRRRKIVSTSFYDRLLCVWDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEL9</accession>
    <name>F9XEL9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_60448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851678.1">
        <property type="nucleotide sequence ID" value="XM_003851630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEL9"/>
    <dbReference type="FunCoup" id="F9XEL9">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEL9"/>
    <dbReference type="GeneID" id="13401885"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_60448"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.715"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="InParanoid" id="F9XEL9"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
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</entry>
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</entry>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF29</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850635.1">
        <property type="nucleotide sequence ID" value="XM_003850587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF29"/>
    <dbReference type="GeneID" id="13397971"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105090"/>
    <dbReference type="HOGENOM" id="CLU_2110861_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF29"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="13294" checksum="DFE711F8E66CF058" modified="2011-10-19" version="1">MHHSLNSTHWWGRRKGCLRRGRGPLHNSSAKSTAASKFTTMWTSTRRLASRRGEIRSTLLKARTAIRIGCGKLFGVLCWYQRWRVGVRRGHWAVRGFVAVFRSASMHSRRTRVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFD1</accession>
    <name>F9XFD1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_100718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850659.1">
        <property type="nucleotide sequence ID" value="XM_003850611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFD1"/>
    <dbReference type="GeneID" id="13397947"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100718"/>
    <dbReference type="eggNOG" id="ENOG502RJ2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028829_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFD1"/>
    <dbReference type="OMA" id="GIWTFQH"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="403" mass="44158" checksum="8166926A4682A935" modified="2011-10-19" version="1">MYRTTDPRFRRRLNEIGQTLESANETAQSSLYIFSQNYIKPCFGAVGNCLGNCVDASCPGVGGKRNARKARAARADRAELSFDFYDDWDEEERDGLLGWGGADDFDRIVGGSGGGYGTTGPAVPAQQQPPRQRGMSYPKGRRKSIGEGVDAAVVNQRGFWGRLFAGKPAPYKPTVADLQDHPGSRWRDRTEGEALLGEDESGSDRIGRRAKTHRRKRSGTQASQETTSSYSSRGDLFPSDEEDDAIPLDDEFAMVWKRRGTMHSGPETDSSSNPVSHKRGKRPSAGSRASTRRTFSSRSTKSARKGTSRTSSSDEDPQSPPHLAELEAQERRVAEEEEAAVQRKREEALRIAAERGLPLHDLKKHATAQTTSAEKAPEMQAASTEPSSQVGQSFIDPGQRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFM6</accession>
    <name>F9XFM6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_73931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851180.1">
        <property type="nucleotide sequence ID" value="XM_003851132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFM6"/>
    <dbReference type="STRING" id="336722.F9XFM6"/>
    <dbReference type="GeneID" id="13397920"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73931"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.283"/>
    <dbReference type="eggNOG" id="ENOG502S4UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFM6"/>
    <dbReference type="OMA" id="LVDMFPM"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35466" checksum="38BB8673BCF8368D" modified="2011-10-19" version="1">MAFAAATAVQQTDSHTYTADFKEAWCIGSVPHGGYVTAIFQTVVKKHFETTLRKQNQPHTLALHLDFLRRTQTGTAKFVVKDVKLGRQTSVVHVTLSQGKREEVVGYITNSNLAKEEGITFTTNWKPHPQRLPVNISSLESNTDANWAELKEWPNVAFRKATAQIRSWFPRNGQVSQNIYDEWMCLRDPTERWTNEKLGFIVDLFPQICETFILEGVDQYTPDGNGVNGEKIPFWYPTLLLNLDVKKALPEGGVKFLFTRLQTKQIKNGRYDLEVVVMDEEGDVVALSHHVCFAVGAERNLAKRKEDGGEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH23</accession>
    <name>F9XH23_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH23"/>
    <dbReference type="GeneID" id="13394438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105598"/>
    <dbReference type="HOGENOM" id="CLU_1856875_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH23"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="15471" checksum="E3FBE7109D1DAB37" modified="2011-10-19" version="1">MWDGKLGLEDGHLALGRMVSEDTPLTFWEIGTGRRRPHEFRNEPPETRMKLLRAIDRPRAAAACSRTILNHNRPTQIPSLSDHSISHVLRAPEGDHEGRTIHSALRHPTLRWKELPLPAVARHAEGESGTSMEQAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH90</accession>
    <name>F9XH90_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849990.1">
        <property type="nucleotide sequence ID" value="XM_003849942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH90"/>
    <dbReference type="GeneID" id="13402784"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95081"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.272"/>
    <dbReference type="HOGENOM" id="CLU_845214_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH90"/>
    <dbReference type="OrthoDB" id="10399042at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="329" mass="35349" checksum="E03E6D64387C570C" modified="2011-10-19" version="1">MATTYSCTVCSFTTQDVNEINTHTTDSNASRELFKCPGATCSALFCLPTQAEAHFKHCASMYTWKAKKKYGILLSEPRVKAACEQDRAGQVATSTRVTGTTAAPAAIAAPATAAAPPQPAAPAAATTSSQPTDSNNTRWHGRQGTKRRGRQTRDEEDREEEEEHGGLSDAKVQVQDFTPRTRAPVGRGPTTRGRSDVDARDAEFGGVMEGFAGLRQTITQQLYGAGAVDMDRVQAETDQLREESARLNARIAAAQANDPMEVGDDHEQDVGNEDEDLDEGDAIAQTARDLPFPGPGYHRELVDGQETLVDPDGGYIDKAGNFHPPRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHA8</accession>
    <name>F9XHA8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_95436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850180.1">
        <property type="nucleotide sequence ID" value="XM_003850132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHA8"/>
    <dbReference type="STRING" id="336722.F9XHA8"/>
    <dbReference type="GeneID" id="13394531"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95436"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700591_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHA8"/>
    <dbReference type="OMA" id="IPSENWA"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="394" mass="42752" checksum="BBA8BF3F282E9FE4" modified="2011-10-19" version="1">MSITTATSNEVLRGSNGRLQFGAPPKTGATRGLQVEPNWAAIIRFLALDVEFAQVLYNGAHNYKQRPGRVSIVNKAGVVIYDVFVHFDDEPEVLDVTLPDAWRKFGVYDNDILASHGARPIAEVEDYVYYIIRHSTVICHAIKGDWDCFSDWVHDQVPTRDTQQLPEYKQHGKAPQFNPKLSTLAEKVLERVIQKGDHSSVEDAKTTMDLYNLREAEFEATQGSRPCPVKEKSATITAPKTPTTTSTSSGSPESSDTPPTELISPMLALASASEPPTPDALAEAIAAIDLVAKPHAHNITKITKTNQGSGEYDEATKPQPIVEATKATSEVALKLMGKVTGVRPSADKPSWARTAAGKAVHTAQPVLSKGISTQVQTAEPPVLKVSWAQVAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHQ1</accession>
    <name>F9XHQ1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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</entry>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="322" mass="35465" checksum="41687D9E53DA6203" modified="2011-10-19" version="1">MSNNTINNCAVAPESTSTDAGIAGTGILLSFIISAFLALFLSAFIVFSEIRAQTSRNITRRILSGLSDSQIFQGIGIQAVGLAKVRTIIPYHFFIIWMLALLSTATNFAALLALVQDFKRDWVLRWLRQFAMFVNVVLTIVYGVFVLRTNLADLAPTLPMACVWQDHEKSEEAQGNKTLSIVGTAAAIAISAIVFVLGTWYLHMRKQTWGKSVRAFSLLVLLGVAIGAAVRVILVSQAFGTPSVKLDDAGETEWSFGQLLVMLLLILPFVSALEIFRGQMQVPHANAFADSDQMPLTSQYGREQKLDHDAEYTYQPNPLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XII2</accession>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Martins N."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
    <sequence length="642" mass="71967" checksum="2785799F76AA5529" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIV5</accession>
    <name>F9XIV5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_101230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849419.1">
        <property type="nucleotide sequence ID" value="XM_003849371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIV5"/>
    <dbReference type="STRING" id="336722.F9XIV5"/>
    <dbReference type="GeneID" id="13402214"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101230"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.360"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIV5"/>
    <dbReference type="OMA" id="WGGLAEF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52572" checksum="6FC36A2294CF4D34" modified="2011-10-19" version="1">MTLTDSAAALVSYASSFAFPPLLSLSRGAILSLLRNIQVGSLQVTDSDGSITICGTPRRAGEVEDEKTVYTIPHAELKVTNDLFWVRLALLADMGFAESYMLGEVSCPDLTAFFKLFIVNKAHLSNGTTFSSNLAGRLSAIIRKTNTLTNARLHISAHYDISNDMFAAFLSPDMTYSCPVWLPRSDPQSTQETLEDAQYRKLTRFITNAKIKSSDHVLEIGTGWGSFAILASQKTGCRVTSLTLSSEQKDLAEARIREAGLSDKITVLLCDYRSLPVPAESEKYDKVVSIEMLEAVGAEFLTTYFRCIDQLLKTEGGVAVFQCITMPESRYKTYSASDDFIRRYIFPGGHLPTITQLLDAIRTGSSNAKTGIEPRLIPESIENIGPHYAKTLRLWRQSFMQQFSTKIRPALLAEHAAGERGGKKMNEEDVEVFKRKWEYYFAYCEAGFATKTLGDVILTVGREGAVEMMEDVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ23</accession>
    <name>F9XJ23_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_95554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849299.1">
        <property type="nucleotide sequence ID" value="XM_003849251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ23"/>
    <dbReference type="FunCoup" id="F9XJ23">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="GeneID" id="13402614"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95554"/>
    <dbReference type="eggNOG" id="KOG3145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1349843_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ23"/>
    <dbReference type="OMA" id="HYILYPE"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="22447" checksum="BA40CCE261C33327" modified="2011-10-19" version="1">MLDEQENERTEQTEYHRVNHGVNRGLESGSMLCGWGYFTLWSLSYYPQPLLNFSQKSTEGLTFDYPVLNVLGSACYFWPGLWRWRSTCVASDRTGKREMSKVTAALVVGCGLAVVTSIAFALVPSGLAMENAADGITWEWIDVISTISTLKLVITVFKYAPQILSNHRRRSARGFTIIGVLLDAGGGILSLVQLVVDCSQQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJR9</accession>
    <name>F9XJR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_47591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849260.1">
        <property type="nucleotide sequence ID" value="XM_003849212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJR9"/>
    <dbReference type="STRING" id="336722.F9XJR9"/>
    <dbReference type="GeneID" id="13402648"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47591"/>
    <dbReference type="eggNOG" id="KOG2371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_2_2_1"/>
    <dbReference type="InParanoid" id="F9XJR9"/>
    <dbReference type="OMA" id="ESPYPMI"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="437"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="680" mass="71161" checksum="B1726B66BC0EE165" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJU0</accession>
    <name>F9XJU0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_82038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849841.1">
        <property type="nucleotide sequence ID" value="XM_003849793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJU0"/>
    <dbReference type="GeneID" id="13398908"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82038"/>
    <dbReference type="HOGENOM" id="CLU_2623900_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJU0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="78" mass="8347" checksum="078BC9BDA3FDABC1" modified="2011-10-19" version="1">MRACVRGWIVLALGMTATALGIPAALRIAAVALMICLRLDLTGYERCARSSGWLAVVEAMAILRPCNLKSGFSMAEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK18</accession>
    <name>F9XK18_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_75829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="328" mass="36462" checksum="3AA6415AE1251DB4" modified="2011-10-19" version="1">MANKTNKRAEQSQAKPEQPTWQLPDDVKNNGEVWSYHYPNKMWFYYDFKNSKYISVRFDGQRFSHPAPPPSKKVAPSSSAAPSLTQAAQRKRSHSESSPPLMHSDGNHRRKSMKTMSGTNGSDQQDQQNQHDQQIQRDQDNQLDIATTGEPTSWPLPQHLKDKNRTWMFQHDVRKWCYWNARIGRYILVDQQGNKSAWVAPPPTPKQITTASITAPASSAPRSSGQSASAEESPLQQQQPQPQETPSIPLQSQPRAAPPGNLAAAKGCHTLLGSTTAAPRSDFSSVLRTSSPSRWATAAEIADFIDAKAKAKTADTKEAERKPVNPES</sequence>
</entry>
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    <accession>F9XKH6</accession>
    <name>F9XKH6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Acyl-CoA thioesterase</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
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                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849559.1">
        <property type="nucleotide sequence ID" value="XM_003849511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKH6"/>
    <dbReference type="STRING" id="336722.F9XKH6"/>
    <dbReference type="GeneID" id="13402344"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48130"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.619"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051867_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKH6"/>
    <dbReference type="OMA" id="DMTGTFI"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="203"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41466" checksum="0AD6C8B443743DB9" modified="2011-10-19" version="1">MPTPGRGGRSTRITPLPEHPGNIYRPFAELIDIEKIDDRTYRSIAPAFSPGGPLGAGRSYGAHVYSQAAWAASQTVAPGFLLHNVSGNFLLGGELNVPFVYKVHIIRNGRSYCTRIVNVTQSQGKGICFTCICSFKTPEHDQFDAQEDLNLYEKYSSALQGKKPTDFPEVPGMDLPFYRKLREETGINDKFPGLECRKVDMSAYNGDRHPLDRRQLIFFRTIGDLPDEHNMHLCAHLYASDRNSLYIVANHFELADHYTGMGSLAHTFIFHSPARAMMFGSTGADDRSKSPMHDQSGRWFCMEIWGSRLGGGRGVHHCRIWNSDGQHVATSIQDGMIRLAANPQRPTDDELKFVDSTTRKWSSVRREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP7</accession>
    <name>F9XKP7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_76260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848852.1">
        <property type="nucleotide sequence ID" value="XM_003848804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKP7"/>
    <dbReference type="FunCoup" id="F9XKP7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKP7"/>
    <dbReference type="MEROPS" id="G05.002"/>
    <dbReference type="GeneID" id="13398616"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76260"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.239"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_1_1_1"/>
    <dbReference type="InParanoid" id="F9XKP7"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="37788" checksum="34FB78E9D929E882" modified="2011-10-19" version="1">MASKLMRTGSHLIHNMRTYYSSTDHPAPITSTTALLLGLLYTTIYIAPFYLSPTLRSTSLASRDSPTIIRARVRAVGLSCLTSTLITLYVLLVPGDASPSDVLRLLGLWPVSLIDCVKVVLLLCVLFAGPLYESILIDDGWRAWNVQSVKDTFWTTYPAYRNMLIAPWCEELVFRSLVISLYLLAQVSPARMVFLTPLIFGAAHVHHLIDYVRTHTPAGHKGVVPPLSVLATGTLISTIQLTYTSLFGFFAAFVFLRTGNVFASVAAHTFCNFMGLPRVWGRVGLGAWPAEARSADGGLGQDSCVSFGDAPMGWTVLYYVLLVGGAVGFYVLLWPLTESGNALVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL61</accession>
    <name>F9XL61_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="13398132"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96244"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.307"/>
    <dbReference type="HOGENOM" id="CLU_814340_0_0_1"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="entry name" value="AN11006-like"/>
    </dbReference>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="341" mass="37894" checksum="AB91D4C1A5341B1A" modified="2011-10-19" version="1">MANNIEAAVFGGACDVVPWKDACKAQPVFDKASRSYKQVVEIAANSSQPLEAYTITSGQAKGYRVLLLAPASKLGLFGLPIELREIIYAHVLVNPLIVELKFFDPSPGKHRIVQKSFPDHTARYPDPSKDWDRHQGKWKTRGRNAISLLLLNKEITAEALKILHGANTFRIDCTRLLEHFLTELTGRGQVQHLRHMQIGKNTISVGTLQEMLTTVELAPNLRTIQVSLPRTWIKAPKKLLRACEPLLQKAQGQGRGGMISRQIEHFVSEIACTCAGCKFRVGDELVDTARQCSDYRKIAARLSQCKKTAARVAEDEKFWKDFSDLVKAKYGTRAAGSATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24632"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="InParanoid" id="F9XLC8"/>
    <dbReference type="OMA" id="HQGRYDF"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
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        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
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        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46648" checksum="404401840F654B84" modified="2011-10-19" version="1" fragment="single">YSQDVDFDQLAKSSPDFAAIIAPAKRKGFIDFKNPKVVQQLSISLLQQDFSLQLTLPQNRLCPPIPVRWNYVRWIQDLLDTSSPTYRDTPDPAREVTGLDIGVGASCIYALLACSTREKWRMLGTDVDAHSLACATRNVKDNGLEKRVKLKQMSPENPLLPLDMLKVEELDFIMTNPPFYDSHADFLAATKRSVDDESGPTPVLTGADNEMIYPGGDVAFVLRILQDSLKLRERVQWYTAMLSKLSSLQQVLAKLKEEGITNFAVTSLQPGRGTKRWGLAWSFGNLRVRNDVGRHGELVVSVLPQPTVQTVEGRGQMSREEVGRKVDELVKGFDVRWMWKEGRGEGVMVAKENVWSRAARRKKKFEEEGRGKSEDEEPVALAVKIICLEGKLEVRWLQGQDHVVFTSFCGVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLD3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLD3"/>
    <dbReference type="GeneID" id="13398654"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110974"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.154"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028757_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLD3"/>
    <dbReference type="OMA" id="HMIIELV"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="608" mass="65948" checksum="1D3B245F4247069B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLV7</accession>
    <name>F9XLV7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_49054</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848956.1">
        <property type="nucleotide sequence ID" value="XM_003848908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLV7"/>
    <dbReference type="FunCoup" id="F9XLV7">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLV7"/>
    <dbReference type="GeneID" id="13398201"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49054"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="F9XLV7"/>
    <dbReference type="OMA" id="RRSVVFN"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="893"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1063"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117852" checksum="3A7FE5C1C8ED18ED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM39</accession>
    <name>F9XM39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_96782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="19"/>
            <end position="773"/>
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    </feature>
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        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="385"/>
            <end position="467"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="773" mass="76218" checksum="4FF4309E5ECF4555" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM90</accession>
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        <name type="synonym">Septoria tritici</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 115943 / IPO323</strain>
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    <comment type="catalytic activity">
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            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
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            <dbReference type="ChEBI" id="CHEBI:73542"/>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MT_TRM10-typ_sf"/>
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    </dbReference>
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        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="121"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
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        </source>
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    </evidence>
    <sequence length="380" mass="41485" checksum="26B61F814A52D518" modified="2011-10-19" version="1">MRKLENGEPENSSANAPSQADISSTASAAQKEQTISQEEANTASSENTEPSLPNPTTFAPLLSSTPTSNDPPLSKSQQKKLKKRLEWESSAASRKAFRKEKQTAKRERLRAHKASLPPAPPKPQPPRAIQLPITILIDCNFDDLMHEGERTSLSSQITRCYSDNKNSGFRAHLAICSFGGKLKERFDEVLKGTYLSWKGVRTFPEGFVEVAGKAKEWMGAEGGGKLKGVFDRPEDPTDEEIEKLKAAGEVVYLTSEATSDLTELKPYSTYIIGGLVDKNRAKGICFKRATQAGIKTARLPIGEFMEMQSRKVLATNHVNEIMVKWLECGDWAAAFMKAIPKRKGGKLKGEGGEEDDAGEGGKNGGEDEKEGSKNVSSPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106029"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="81" mass="9426" checksum="B0909C87F7BB9E8A" modified="2011-10-19" version="1">MRYASGLNLWCLPSTVIVHRTWQHDQRLRTWTLILAKKCPIRNVRYSGAVARDNANLTALAEHCRRLLHFGRALRKARTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMG2</accession>
    <name>F9XMG2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_49575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848731.1">
        <property type="nucleotide sequence ID" value="XM_003848683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMG2"/>
    <dbReference type="GeneID" id="13396096"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49575"/>
    <dbReference type="eggNOG" id="ENOG502RR78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMG2"/>
    <dbReference type="OMA" id="EDDRWIK"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30305" checksum="D4516F11AF528ED9" modified="2011-10-19" version="1">MASNNRTYGTVPGSQNGTVNSSDEESASLLAKTTSPSFAKRTHRYFNANVSNTWGDVALLFCYIITGILDSSSVLTWGSFASMQTGNTVYIGSGIVAPHEGDRWIRASTSLGFFLLGSFFFARYHRYFSPRKRWVVVSSYTLQLAMVTIAAVMITIGPSTTPKDPITVWVTVPLALVAFQSAGQAVISRVLKFNALTSVVLTSIYCDLASDEKLFAGVTENPERNRRVLAPCLLLLGAVIGGFWAHSEVGMTGALWTAVALKAVVVLMWCFWTEEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMN6</accession>
    <name>F9XMN6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SPT1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_76712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848694.1">
        <property type="nucleotide sequence ID" value="XM_003848646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMN6"/>
    <dbReference type="FunCoup" id="F9XMN6">
        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMN6"/>
    <dbReference type="GeneID" id="13396375"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76712"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="InParanoid" id="F9XMN6"/>
    <dbReference type="OMA" id="ITIRHAI"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="133"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="522" mass="57547" checksum="1602F0D01AB287C3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMQ1</accession>
    <name>F9XMQ1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848310.1">
        <property type="nucleotide sequence ID" value="XM_003848262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMQ1"/>
    <dbReference type="GeneID" id="13396549"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96536"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.120"/>
    <dbReference type="eggNOG" id="ENOG502R997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115969_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMQ1"/>
    <dbReference type="OMA" id="KPPGDCT"/>
    <dbReference type="OrthoDB" id="3637047at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391782" evidence="1">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="16899" checksum="A13EC662F432D399" modified="2011-10-19" version="1">MKTFFAIAASAAMTLAAPAVQDPAAPTCRDGGQLHCCQATFTGSAAPVTLAADLVCYDLTPAVLNCIITKAPIDPEFGCVGEYACCQVNDLDPVLGLYCSKPPGDCIGREGGDPAYCTEVLEGRFGNCTDNDVRNNQGLLGIATKPLKGLTGLVGGGKKGGLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMT5</accession>
    <name>F9XMT5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848662.1">
        <property type="nucleotide sequence ID" value="XM_003848614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMT5"/>
    <dbReference type="GeneID" id="13396540"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96565"/>
    <dbReference type="eggNOG" id="ENOG502T3J3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691175_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMT5"/>
    <dbReference type="OrthoDB" id="3650883at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44994" checksum="FBEC2B3F5EC0ADF9" modified="2011-10-19" version="1">MAAMYPPREGTRAALALQRMKEWPSVRPTLGPILEKRRKVRGSELISPRLMWDLSTLYSDDEWTILDGVNAMELVPTLAEWPGRRHHLDPLCVFLNRIAESVYPEWLASADERAAKEAKVDKRPFRFLDLPAEIRTQIYDIVAADMHPKGLVRRQRIGTYWDHELLGTPLAQVNKQLRSEFLPRWFRIGECIVWGDSECDQSWLSLFGASRVPLMRNFDFQFGDDSVKVELQGAPASVNYDCANNKFFLLPQESSISSGQRIRVSSPKAWNSTSAEVRKLRDDDFESKFQSFVESLLEEDGDGYVYLTAEGLVQIIEHLQGTVVPTQAVDVSKRQDSVVITALQIRTGPGASHVALIVNIATSTATYTHMPVLHVAESQVPQDSSQGHIGRNEALQGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN70</accession>
    <name>F9XN70_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_10621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848385.1">
        <property type="nucleotide sequence ID" value="XM_003848337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN70"/>
    <dbReference type="SMR" id="F9XN70"/>
    <dbReference type="STRING" id="336722.F9XN70"/>
    <dbReference type="GeneID" id="13396505"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10621"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="F9XN70"/>
    <dbReference type="OMA" id="CFAQQQH"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030958">
        <property type="term" value="C:RITS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070551">
        <property type="term" value="F:endoribonuclease activity, cleaving siRNA-paired mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033562">
        <property type="term" value="P:co-transcriptional gene silencing by RNA interference machinery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070317">
        <property type="term" value="P:negative regulation of G0 to G1 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="227"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="505"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="89757" checksum="8F76A2D066919F36" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNH9</accession>
    <name>F9XNH9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CH5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_111436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848188.1">
        <property type="nucleotide sequence ID" value="XM_003848140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNH9"/>
    <dbReference type="STRING" id="336722.F9XNH9"/>
    <dbReference type="GeneID" id="13401768"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111436"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNH9"/>
    <dbReference type="OMA" id="AEWIISF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395702" evidence="11">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="215" mass="24034" checksum="A56391594B03439B" modified="2011-10-19" version="1">MTPTSTILFVFLVQLSLSIISTIGAQKVNDIAWWFFTLIFTSSGKNDKEARKLRSEVVRLSREMKATSAQDNFAKWARLRREHDKAKEAYDKMTRNSSSTRSSFDSIFSKLRWLGTQGINFIVNSTFSKQAMFWLPKGWLPHSAEWVLSLPRAPLGSISVNVWALACGAVIAMITEGVAALWALRSKAADSSKGQMQKEKIAMPGNGLGQEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNM3</accession>
    <name>F9XNM3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847922.1">
        <property type="nucleotide sequence ID" value="XM_003847874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNM3"/>
    <dbReference type="GeneID" id="13401669"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106335"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.171"/>
    <dbReference type="eggNOG" id="ENOG502S4XH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063722_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNM3"/>
    <dbReference type="OMA" id="CYNITIT"/>
    <dbReference type="OrthoDB" id="3554264at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391804" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="83"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="238" mass="24273" checksum="E3C56A7B66D05AE7" modified="2011-10-19" version="1">MKYSYAALALSAVAFAAPAPSVVEDCDETVPAVQHPAVQHPAYQAPPVALPSPIPSNDANCPKVECPAGGDKKAANFPIKFTSTFSIVATPDQVVNSTNVPTGGLEGAVGYYDFGLNSDLNLICYNITLVGVTGAYQSPADTATHIHQSALGRSGPPRIAFPNPTIVEGSNIRQSVGCLSGPFVTGIEAADNVTDTGSASGFTIAAIEANPSAFNADVHTADAVPGAVRGQFGAPLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPI3</accession>
    <name>F9XPI3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_77226</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848219.1">
        <property type="nucleotide sequence ID" value="XM_003848171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPI3"/>
    <dbReference type="FunCoup" id="F9XPI3">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPI3"/>
    <dbReference type="GeneID" id="13401510"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77226"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.65"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="InParanoid" id="F9XPI3"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:methionine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
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    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Met-tRNA_ligase_1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
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        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="583"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="652" mass="73375" checksum="740FE83553F35F92" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ89</accession>
    <name>F9XQ89_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="275" mass="31518" checksum="B444008A9F29CC25" modified="2011-10-19" version="1">MWSESGHELSLALAGILESATFLFNSVSSRHHFVAHFGDHVVVKAISEPDSTEYSTLQFLETRSPTIPAPRPHGVISIGNTWYMFMDLVSGVNLETVWLSLTEPQKEAISRDLNILLQQLRAVPYEPGTPLGGVGGQGCKDFRRHIRTSDAPIYSTEQLWNFMYGNARRKDTVYGRFLRKQTFPPRKQNIVFIHGDFRPANIMVDHSDKANIRITGLIDWEMSGFYTEDMECIKATNNLSSLDCDEWYLHLPELIDPRHHLESWYADLMWDPYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQW3</accession>
    <name>F9XQW3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847374.1">
        <property type="nucleotide sequence ID" value="XM_003847326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQW3"/>
    <dbReference type="GeneID" id="13400155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106616"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.43"/>
    <dbReference type="HOGENOM" id="CLU_2759751_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQW3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="70" mass="7758" checksum="4863EB9F24E89F76" modified="2011-10-19" version="1">MYRPDQTCRFCSETCRARWPLPPPCPLARHIRIISATPTATATAIHSHLSESRQTPSRQVSGGLEDQVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR48</accession>
    <name>F9XR48_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847299.1">
        <property type="nucleotide sequence ID" value="XM_003847251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR48"/>
    <dbReference type="GeneID" id="13399875"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97710"/>
    <dbReference type="HOGENOM" id="CLU_2039909_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR48"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13349" checksum="D83D9106926F2ECF" modified="2011-10-19" version="1">MVKFLRYPYWSLASLSTVIQADIFAIIQLIKDASRATSAASVRMAASLSACSPSRNATSLKLQSRLHIAKGKTEDALSSTHRHLDRTSYWRAEECEPLKAAAKQTKVDTISLRLEIDALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR61</accession>
    <name>F9XR61_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847291.1">
        <property type="nucleotide sequence ID" value="XM_003847243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR61"/>
    <dbReference type="GeneID" id="13400096"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97721"/>
    <dbReference type="HOGENOM" id="CLU_1031365_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR61"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="270" mass="29414" checksum="88A452BF746C4C24" modified="2011-10-19" version="1">MHGYIAQRCMAVHFHCRIQAMDSDSDSDYEYLSSPDPKKHSPRTLVRKKQQRKFLDDKVRLEQQQEASERKMGFSPFRRQGLSSTAMPSGSDKAWATGSNWVTYRPCARSDGETGGSAGQLAADGDLQRSWRHESSPLEGTSSLNQLHKDRTYASDAYSVVNNPTSSSANSRTINLFEQAGKAPNVNAASSHAGSSMRCPSDGHSLSGNAISARPPPPFYAPPLGSVSGTMGPPQHHIHPRRLSTPPSGPRFTEEDDVDLYDSTPPRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW59</accession>
    <name>F9WW59_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_32625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003855977.1">
        <property type="nucleotide sequence ID" value="XM_003855929.1"/>
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    <dbReference type="STRING" id="336722.F9WW59"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32625"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002738_3_1_1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="306"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="423"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="578" mass="64439" checksum="0CFFE95C7C07D62F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWA0</accession>
    <name>F9WWA0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="8">Hydantoin utilization protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_106986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP91055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003856031.1"/>
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    <dbReference type="STRING" id="336722.F9WWA0"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106986"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002157_2_0_1"/>
    <dbReference type="InParanoid" id="F9WWA0"/>
    <dbReference type="OMA" id="WYRSDLT"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ACX-like_C"/>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF23">
        <property type="entry name" value="HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="208"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="536"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="766"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="141635" checksum="0606EA0647265203" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWA7</accession>
    <name>F9WWA7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_106991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857565.1">
        <property type="nucleotide sequence ID" value="XM_003857517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWA7"/>
    <dbReference type="GeneID" id="13403136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106991"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9WWA7"/>
    <dbReference type="OMA" id="CNKQADR"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="96"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="542" mass="59532" checksum="1F3C9CF84374D269" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWC7</accession>
    <name>F9WWC7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_23438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857555.1">
        <property type="nucleotide sequence ID" value="XM_003857507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWC7"/>
    <dbReference type="FunCoup" id="F9WWC7">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="GeneID" id="13394345"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23438"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="F9WWC7"/>
    <dbReference type="OMA" id="FCCAVAV"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="14"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="412" mass="44280" checksum="808310F6D78F28EE" modified="2011-10-19" version="1" fragment="single">DGNEYPEGGLRAYLVVFGSFCGLLAALGIMNTVGLYQAYLGENQLSGYSESAIGWIISIYVFLSFGVGLIIGPIFDVYGPRWFVLAGSICIMVCMMLLGVCTAYWHFLIVFGIIGGVGTALIFTPAISSIGHFFYIKRGSATGLATAGGSLGGVIFPLMLQNLFPKVGWGWATRIQGFAFLALLVATNLLVRSRLPPKPGQSILPDFRIFRQVDFALVTAGIYFMEWGLFAPITYLTQYALYSGAMSTTFAYQIIAIFNAGSTLGRWLPGYFADRIGRYNTMILALALCLVASFGLWLPATLLSASDDRDSHKTAVFGLTIAFSVVFGFASGSNISLTPVCVGQLCETEQYGRYYATCYTIVALGTLTGIPIAGALVQACDGAFWGVAIFTGMCYAVSIAAFVTVRVMRGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX08</accession>
    <name>F9WX08_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_98822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856688.1">
        <property type="nucleotide sequence ID" value="XM_003856640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX08"/>
    <dbReference type="STRING" id="336722.F9WX08"/>
    <dbReference type="GeneID" id="13398094"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98822"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="InParanoid" id="F9WX08"/>
    <dbReference type="OMA" id="GLFTWET"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="241"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44977" checksum="895ADAF2C6EB0BE7" modified="2011-10-19" version="1">MPQGIPETAPKTPTNTFGNPAPWSEPAWSQGVASPYYKDSHRELRKTIRKYIDTNIIPEHLAWEEKGEAPRSVQLDWAKSGFAFSDVPMKYRPEGIPYPAGIPLDKLDVFHLLVQTDETSRVEGGVMSGLGGGSVIGIPPVIHHGTDEQKRKWLPGLFSWETSFCLGITEPSGGSDVANIQTTATKTKDGKFYVINGYKKWITGAPWATHMTTAVRTGGGASLVELDDVHVPVENLLGKENQGFKVIMVNFNRERFIMSVSSNRKARTCLAVAFDYANKRETFGKPLISNQIIAAKFATIARYVESHWAWLEQIAYAVQQSPLGFQDPDVAGRIALAKVQAGRIQELANREAQQVLGGAGYQRGGPGAVVEQMSRDLRMMVVGGGSEEIIADLAVRQETIQAKKRGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX65</accession>
    <name>F9WX65_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_67551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856887.1">
        <property type="nucleotide sequence ID" value="XM_003856839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX65"/>
    <dbReference type="FunCoup" id="F9WX65">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WX65"/>
    <dbReference type="GeneID" id="13398522"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67551"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2015"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="InParanoid" id="F9WX65"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="376"/>
            <end position="436"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Churchill A.C.L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </feature>
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            <end position="250"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28226" checksum="F098F15A8A576BE8" modified="2011-10-19" version="1">MVTPKMSCPSGASFYACGAGSKFVGCCASNPCGTTGCAAGSLRSTSFDSGQYNELPDQECSKGRFYKCSAIDPPFWGCCSSNPCGTGCPQSDLAGAFLSANEATAQPYLSLNTTWSDSSPGKTPKDDSDSKSGGPKDKHETNIGAIAGGIVGGIVLIAIVAAIILLLRRRKRRAAAKYKAGIHRPQPELQAMYPDMDESMAKHGTHSYETSPALSSNPRSPGQPPYSPQPPSYWTEAQARHVSHELRGESAVEMEDNSVPAPVSANATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYQ4</accession>
    <name>F9WYQ4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855914.1">
        <property type="nucleotide sequence ID" value="XM_003855866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYQ4"/>
    <dbReference type="GeneID" id="13403853"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102033"/>
    <dbReference type="HOGENOM" id="CLU_2051501_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYQ4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="120" mass="13111" checksum="D31925961DBB9C71" modified="2011-10-19" version="1">MRDHRGQQHSTPCQLYDFVTSSCSRCIMPSPCFCESPLPRLHGRGAGSAALIFHASSYATAACSIEERGLPFQLLSQTRSDYRACARLLPCGFLPLTIDLKPSAIAAMLLSESVGWFDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYX6</accession>
    <name>F9WYX6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DCW1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_33386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856039.1">
        <property type="nucleotide sequence ID" value="XM_003855991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYX6"/>
    <dbReference type="STRING" id="336722.F9WYX6"/>
    <dbReference type="GeneID" id="13403978"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33386"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="F9WYX6"/>
    <dbReference type="OMA" id="WSQSMGN"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395433" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="478" mass="51226" checksum="D1149AD71367F813" modified="2011-10-19" version="1">MRGISGFGLTSLALSAGLANAIDLDVNNRDSVLKASKIVVDNILSVYNNYTESPGGIPGLLPQPYYWYNAGNMFNSLIKYWALSGDQSIVPTLQSALVFQLGPDFNYMPPNQSKSLGNDDQAAWALAAMSAAEYDLPVPNDLLSNNITWASIADTVFKEQVARWDTESCGGGLRWQIFTFNNGYNYKNSISQASFASLAARLHRFTGNSTFYGEWATRAVEWTRSIGLMNQNGQTFDGTDATTSCSEINRLQWTNNAGLFLTTGAYSANAVYSATGRYWSELNQLVTNSSLRIFVYEDRNIIYEVACEPSDNCNIDQTGFRAQFVRSLATYRDMAPASDDSVYRQNITAVLRASATAAAAACVYGENGTSCANSWYDPVDDTEDYYGQINQNLNALEVFLANLPSGDIKMGVGSTNGTGVGGSLGGGANGTERGDGNGSGTGSNSPQSSGDGTGAASTLMVSSMLAVVGMFVELFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ54</accession>
    <name>F9WZ54_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_28143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857390.1">
        <property type="nucleotide sequence ID" value="XM_003857342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ54"/>
    <dbReference type="GeneID" id="13394671"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28143"/>
    <dbReference type="eggNOG" id="ENOG502S1BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_3_2_1"/>
    <dbReference type="InParanoid" id="F9WZ54"/>
    <dbReference type="OMA" id="KWRIFTH"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="154" mass="16755" checksum="9B1FC7C407EDFA7C" modified="2011-10-19" version="1" fragment="single">QAQHGWFQNLIENFGSVELENKGSVARDHLALERTFLAWLRTSLAFASIGIAVTQLFRLNTSIAQPHSSSAEHTSFVATGKLRSVGKPLGATFLGISILVLLLGFHRYFESQHYVIRGKFPASRGTIIIISVVAFALIVASLVVVLAVAPHAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZA5</accession>
    <name>F9WZA5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857262.1">
        <property type="nucleotide sequence ID" value="XM_003857214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZA5"/>
    <dbReference type="GeneID" id="13394962"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89590"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1208"/>
    <dbReference type="eggNOG" id="ENOG502SH8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_1"/>
    <dbReference type="InParanoid" id="F9WZA5"/>
    <dbReference type="OMA" id="HRIAWGT"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="318" mass="35503" checksum="A0026DEA956F8B50" modified="2011-10-19" version="1">MDLPSSFPYKAWTIRYNVIESESASTPSQTRGEKRSIVFVHGTPWSSAVYKPVISSLLATNTPYRILIYDLPGYGRSQAYFSTSPDAVTKANLPGDTSVAFQAQALAALLEHTHSSSSDSQTPPAVIAHDIAGAIVLRAHLLHGVEFSSMLLCDTNAVLPWGDGFYKLVRSQPQVFLELPRHAFEAVVIFVVKSALHRAKEVGDEWVDVLSSPWVGGASEVESKERQMSFVRQIAQADDGDVKQMLDQQVYRKVRCEVKMIRGEEDSWIPREKLEELRERMGVTVKELVPIADAGHLVMLDQPERFEREVFDWLSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZJ0</accession>
    <name>F9WZJ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_64923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-mannitol + NADP(+) = D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16767"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857773.1">
        <property type="nucleotide sequence ID" value="XM_003857725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZJ0"/>
    <dbReference type="STRING" id="336722.F9WZJ0"/>
    <dbReference type="GeneID" id="13403789"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64923"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.85"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="F9WZJ0"/>
    <dbReference type="OMA" id="GAHFKKQ"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="266" mass="28473" checksum="CC8D943E6389F472" modified="2011-10-19" version="1">MPQRIPEATELKDLLSLKGKVVVVTGASGPKGMGIEAARGCAEMGADVAITYSSRPEGGEKNAKELAEKYGVKVKAYKCQVDKYENCEKLVADVVAEFGKIDAFIANAGATADSGILDGSVEAWNHVINVDLNGTFHCAKAVGHHFKERGTGSLVITSSMSGHIANYPQEQTSYNVAKAGCIHMTKSLANEWRDFARVNSISPGYIDTGLSDFVAKDVQKLWHSMIPMGRDGLAKELKGAYVYFASDASTYTTGSDLLVDGGYCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZL6</accession>
    <name>F9WZL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MgSNF1</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_98201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855933.1">
        <property type="nucleotide sequence ID" value="XM_003855885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZL6"/>
    <dbReference type="FunCoup" id="F9WZL6">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZL6"/>
    <dbReference type="GeneID" id="13403276"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98201"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="InParanoid" id="F9WZL6"/>
    <dbReference type="OMA" id="TEWHPIS"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP90909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="767" mass="85177" checksum="389B35746FB5EBCC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZW3</accession>
    <name>F9WZW3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9WZW3"/>
    <dbReference type="GeneID" id="13394319"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98302"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.509"/>
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    <dbReference type="HOGENOM" id="CLU_034963_2_0_1"/>
    <dbReference type="InParanoid" id="F9WZW3"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="165"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="34231" checksum="3B99688EE5EF9EBB" modified="2011-10-19" version="1">MEELQTQHRKELRDLQSRITQKKKQASKKTRKGINDECDRLEAETKERHQAEIAALNGQDAGNEALPIEQLDELTLKVDHAEEDESTSGTAHDSERTHAQTTPNPEEVESTAGGKKPSRQKARLARRAAEQEEIARQAAEEAKNLPDMKEQERSRMKDALKQHGLVEKEIRADGHCLYSAIADQLEQLEIPIGSSPNGEALVGYKLVRAKAAEYIQQHEDDFVPFLEEPLPDYVHKVRNTGEWGGQLELMALAKTYTVDINVLQDFGRVEKIEGGSGDAAGKSAWLGYYKHGFGLGEHYNSLRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X019</accession>
    <name>F9X019_ZYMTI</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X019"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="199"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP91156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="427" mass="47446" checksum="4EC104500AA4A0E0" modified="2011-10-19" version="1">MSSSSSPEREEKKRKRTSVPKNDAGELEIDVNLPEPPSKKAKRKEKKQSKSKAPRTESVNTAEGTNETEDATPKAVVKSATSTEPVKRSENGIWIGNLPYSVNRESLQEFFLNAGGIGSTDIMRINMPLNERKQNKGFAYVDFTSPAVLEIALALSEKLVNGRACLIKNANSFEGRPKVSTEAKAADAAAKAAGKEPTKRVFVGNLGFEATRDEINEHFSQAGQVEDVFLATFEDSGKCKGFGWVTFADIESASQAVRGFIWKKQEEEDGDDDAGSHVENDSDEEDNKPKRKPKKPMKWFINRIHGRELRCEFAEDKQTRYKKRYGKAPPATTEQRGGASRYNEATAGEARRGEENLQDLLREAQDAAPKRRDPKMKKMNKDERQDVRRQKFDARKIAPGKALANAERSSKASGAIPKTSGTKKTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SQGD">
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    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="20226" checksum="2A924CAEC37A41F6" modified="2011-10-19" version="1">MRLSTLDILPTVLLASVVTALQLPDIQPFLAALPDVFQNYLATPIQNTTAQELLKRQSSNSCPNGFNSCANLGAAGLCCMSNAVCSADNAGHVACCPSRAVCTGTIGGVITAGTINGNGGLVGGATGVGQTVTTSFQLAGTTTNGGGLVQATAPPTTNPGVATGNGGFIIDGGNTVAVPAGGVRRAEIPGIVAAIIYLLEFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1A0</accession>
    <name>F9X1A0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_31949</name>
    </gene>
    <organism evidence="10 11">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857184.1">
        <property type="nucleotide sequence ID" value="XM_003857136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1A0"/>
    <dbReference type="STRING" id="336722.F9X1A0"/>
    <dbReference type="GeneID" id="13399123"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31949"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1A0"/>
    <dbReference type="OMA" id="RNDIRCG"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395466" description="Agmatinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41049" checksum="387686C20CC4D875" modified="2011-10-19" version="1">MTRISLPFLTLLGLASARDIVFPPVAAMQQPIGSFAVDIAEDPALDISGARYLGLTTYANLPYVHCLAAEGEEVEAYDIAFLGAPFDTGVTARPGARFGPNGIRQGSRRIEEEAAWNVYTGMNPFKQGLVIRDCGDAPLTVLDNTIALKQLDKAHKVVSGRKTNSSEFTVPRIITLGGDHTTTLSALRSTFNHFGKVSVIHFDSHIDTWDPQVLSGGISDYAGVNHGTFLHIAAEEGLISNSSIHAGIRAPVANKKYDMKHDRACGFHNLKARDLDKLGMAGFIEKIKERVAGSKVYISVDIDVLDPAYAPATGTAEPGGWTTRELLTILDGLNGLEVVGADVVEVAPVYDNGGETTVLAAAEVALALLQVMVDTEVAPVEKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1R7</accession>
    <name>F9X1R7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PTP3</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_36281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855110.1">
        <property type="nucleotide sequence ID" value="XM_003855062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1R7"/>
    <dbReference type="STRING" id="336722.F9X1R7"/>
    <dbReference type="GeneID" id="13400052"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36281"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_11_2_1"/>
    <dbReference type="InParanoid" id="F9X1R7"/>
    <dbReference type="OMA" id="CAYLMWK"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF5">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="21405" checksum="46C723CEC4E37063" modified="2011-10-19" version="1">MGWLDLVPRAGNLYIGGLHALYQKPDLFKAAKITHIVSVLDYDLYENDHFKHFKHIQIKLDDDPNEVLLKHFSETNAFIDNALSNGGAVFVHCAMGKSRSATIVCCYLMWKYNISPELALAQLCEGREVCDPNPGFKEQLKVYELMLKAPNEAEAQSIFQKWLDTRYTGTWYSGTFRSMTTSRRSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X299</accession>
    <name>F9X299_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855588.1">
        <property type="nucleotide sequence ID" value="XM_003855540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X299"/>
    <dbReference type="GeneID" id="13403528"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90696"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.504"/>
    <dbReference type="HOGENOM" id="CLU_1143325_0_0_1"/>
    <dbReference type="InParanoid" id="F9X299"/>
    <dbReference type="OrthoDB" id="10382612at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="243" mass="26956" checksum="C23631A023DB9AE6" modified="2011-10-19" version="1">MVDSSLPYGQEKLAAEKKKGAAKRASSIAFNNEQHQPGAAQREQDDQTSSPIKKRKRTPSRKVAESMNAPPTTAPVAPMTASSHDSEDQDIPREGRLGGLMAQLNAAYQTVQTEQQEAIILVRNLKRENKELEDKVEALERGAKDTEKTMINIADLQQAVNERDEALAKLESDNEEIHKAKAKMKDDHDEAMGKMKSDYEDTMEEMKKAQSDLAAIRVTLKSFVGWFAGSTAEAIERITKMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2B9</accession>
    <name>F9X2B9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgASP2</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_99102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854918.1">
        <property type="nucleotide sequence ID" value="XM_003854870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2B9"/>
    <dbReference type="GeneID" id="13399407"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99102"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="InParanoid" id="F9X2B9"/>
    <dbReference type="OMA" id="TKATFDW"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="43"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="353" mass="36658" checksum="6F6B2E713B05C4B3" modified="2011-10-19" version="1">MAKTYGKYSKHGAKAPADVSRAAAAATQSGSVKASPEQFDQSYLCPVTVGGQTLNLDFDTGSADLWVYSNSQPSSQQTGHSVYTPGSTAKRLSGQTWKISYGDGSGASGIVYSDKVVVGGVTATGQAVEAAQTVSDEFVQDVDNDGLLGLAFSSINTVSPTQQKTFFDTVKSSLAKQLFTCDLKAGRAGTYDFGYIDANKHTGTITYVSVDSSQGFWTFNAGGYSAGSAAVSGSIGSAIADTGTSLVYLPTDVVTAYYSKLSGAAYDSNQGGYTFPCSRSPPNFNVKIGTQTFTIPGSYIKYAPVDSSGSTCFGGIQRNTGIGFTIFGDVFLKAVFAVFDVSTGSPRLGLAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2C2</accession>
    <name>F9X2C2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin nucleotide-binding domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_68312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854920.1">
        <property type="nucleotide sequence ID" value="XM_003854872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2C2"/>
    <dbReference type="FunCoup" id="F9X2C2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2C2"/>
    <dbReference type="GeneID" id="13399409"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68312"/>
    <dbReference type="eggNOG" id="KOG2530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022511_2_0_1"/>
    <dbReference type="InParanoid" id="F9X2C2"/>
    <dbReference type="OMA" id="SYETGWM"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54750" checksum="2822BEE9DB382A1D" modified="2011-10-19" version="1">MHEIVTLQFGQQANYIGTHYWNTQESYFTYGAEEESPVDHDISFRPGIGADGAETFTPRTLIYDLKGAFGTLRRENALYELQHQENPAQQSQWGGNTIPLNLPPIAPSSYQQALDQGLTPPTLSTETVRFWSDYNHLFYHPKSIVQLNEYELNSDLMPFEQWSKGEELFANLDREHDLLDRDLRPFLEECDQLQGIQVLSGIDDAWGGFASKYLERVADELGKGSRWVFGLQDTQRTTRDRYALQLANVAQSLHSIDTSASMHIPLGSVPTTLPGYVILDNASRWSTSALQAAGIESLTLPTRLRRNQSAYASFDSLEATLNGDGKRRIAGCSLSITDAAEKGLDVDLFPTLPHTLTSTRGQRSQRPHTFSKITTLRGAWKSPSSIHQSNEIARDRFASSSDVRTSIHQSHLLFPILSSSPQIFHFAARPSKVAIQASMATSTAIGGHIRGVEGVARRMVGLEEREALCDGLAALADEYEDGWLSENDSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2I0</accession>
    <name>F9X2I0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_36370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855028.1">
        <property type="nucleotide sequence ID" value="XM_003854980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2I0"/>
    <dbReference type="FunCoup" id="F9X2I0">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2I0"/>
    <dbReference type="GeneID" id="13403401"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36370"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="InParanoid" id="F9X2I0"/>
    <dbReference type="OMA" id="LQGMVWE"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25966" checksum="0972529A168BB374" modified="2011-10-19" version="1" fragment="single">LEGTICEIAFVKSVLFPYAIGALPTVLSEKWSDPAFAAYRDAFPEAHRESPKALQAHVEDLTARDVKVAYLKNLQGYLWEEGYKSGAYSTPLFPDVVPKLRDWRRRGLELAIYSSGSVFAQKLLFGHVQAESSESGSHKKVEDLTELFGDEAWFDTTNAGLKTEASSYAKIAESLKPSTMLFLSDNVKEVDAAIEAGMQSILVDRPGNAAVSEADRSRLQVVTSLDEIEITGQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J9</accession>
    <name>F9X2J9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_107834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854727.1">
        <property type="nucleotide sequence ID" value="XM_003854679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2J9"/>
    <dbReference type="STRING" id="336722.F9X2J9"/>
    <dbReference type="GeneID" id="13403729"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107834"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2J9"/>
    <dbReference type="OMA" id="WRKQGDD"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="512" mass="56122" checksum="CB5D82D9C2F89BAD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3G3</accession>
    <name>F9X3G3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_103060</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854771.1">
        <property type="nucleotide sequence ID" value="XM_003854723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3G3"/>
    <dbReference type="GeneID" id="13403688"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103060"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.179"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_2_2_1"/>
    <dbReference type="InParanoid" id="F9X3G3"/>
    <dbReference type="OMA" id="PYVDCQS"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="211"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="488" mass="53930" checksum="84B9704045092708" modified="2011-10-19" version="1">MFRKQLVQAALKSTRLPANKGPGIRHISSSYVRFNATPLSSQVDRVARDEPFDRTGSSSKGYQQSSKLDRQSGFEPSAVSSQKPSVRHLSKHPLPRFEAGDVDHLSLRFEDGSLKIVDEREGRSTTIPGRWLRDNCACSQCRNGDTAQRQINVFKGTLDCTVINCDIANGQVGSATVTFSDGHQSEFPTQSLLRRRSDGVTKGRYGRTTIKPWTADIASSRPSVPYTEMSIDAGMGTLLHRIRTYGFCIIEDLPATPEATESLLECIGPIRNTHYGGFYDFTSDLSSKDTAYTSESLEPHTDNTYFTEPAGLQALHMLSHTDGSGGESSLVDGFNAALQLYNTDPEAYLTLSNTGVYAHASGNEGISIQPAQAFPTLSHHPEQGYLTQVRWNNADRAGIAADFADVDRWYDAAAKFDALLNDPKNVYWFQLKPGQLLLFDNWRVLHGRAAFTGKRRMCGGYINRDDFISRYRATNLSEGEVRLATVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3L0</accession>
    <name>F9X3L0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARF/SAR superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_37446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854872.1">
        <property type="nucleotide sequence ID" value="XM_003854824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3L0"/>
    <dbReference type="FunCoup" id="F9X3L0">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3L0"/>
    <dbReference type="GeneID" id="13403580"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37446"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_7_3_1"/>
    <dbReference type="InParanoid" id="F9X3L0"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24718" checksum="5DA4FAAF31E944BE" modified="2011-10-19" version="1">MYHLAQALWLHATSKEEYSILVLGLDNAGKTTLLEQIKSLYNDAHQPNLKTVPTVGQNVSLIDLPELYLRIWDVGGQHTLRGLWQSYYRSCHAIVFVIDSTDVGDADIERLGKGPSKEDEEGRLEECRLVLEDVLQNEETEGVPVLVLANKQDREDCVEVVRIKEGLVRKVFEGEKGQNVRDSRVLPLSALTGTGVKEAVEWLCSRVKWNKEGRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3R3</accession>
    <name>F9X3R3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_103278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854969.1">
        <property type="nucleotide sequence ID" value="XM_003854921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3R3"/>
    <dbReference type="STRING" id="336722.F9X3R3"/>
    <dbReference type="GeneID" id="13403462"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103278"/>
    <dbReference type="eggNOG" id="KOG2393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862115_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3R3"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="37407" checksum="708BA38710DFD08D" modified="2011-10-19" version="1" fragment="single">MRLHRRYARDKMEVADLSDANSGADDKEREQMTARRAERQAEREENQKLIAPTGGEASKPVKKKAAKKVEEGRDNTDPVRMKRQQLRYEEARPWHLEDFEGKNVWVGSYEQALSENSIMLVLAEGGFQMVPVEKWYKFIQTNKVNAMDSEEVEKHMAKKFNMPRWALGTQLANEVARKEARSQMIQAHRAKSREADDDVPKREMDDGDFQADKDMLDLDVQDEFQDDDEGMLFQGEDGEDGDDIAKRIYLEMRDAGLGGTGVKKEDVDPVEEERRREMAERDEMVKHKRLRKQLRKKEHQNQYDSDDSNADPYASSSESVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X430</accession>
    <name>F9X430_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_108330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855179.1">
        <property type="nucleotide sequence ID" value="XM_003855131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X430"/>
    <dbReference type="STRING" id="336722.F9X430"/>
    <dbReference type="GeneID" id="13400272"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108330"/>
    <dbReference type="eggNOG" id="ENOG502SK06">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058473_0_0_1"/>
    <dbReference type="InParanoid" id="F9X430"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="29778" checksum="BE09FEF08B41DCC2" modified="2011-10-19" version="1">MKHETLTSTKSNPLLAAIATQTTTSILTSWPFSTNASRSRFLAADIPSLTCCLFPYAIEERIHIAASLVSLLLLLDDELPELSVDEGEEFLEYLRSAVGGGWQGEEDEDRPAVSMLSGVLDELRGTDYEVGGEVVGAMWEWLRSRNVSRRSRRSGPDVMRDFYRSVEGTELRWHLMRFVMDVSADGDLERLGLRSPRRKVVEDADRGRTRRRRKQTRQMMQMHVAVSILSSASIFQSSRVRWASIDQENFKQLSLQATESGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4C3</accession>
    <name>F9X4C3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_36820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854895.1">
        <property type="nucleotide sequence ID" value="XM_003854847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4C3"/>
    <dbReference type="STRING" id="336722.F9X4C3"/>
    <dbReference type="GeneID" id="13399384"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36820"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4C3"/>
    <dbReference type="OMA" id="MEMPSML"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="400" mass="45161" checksum="7D895FE6AD1B9FA8" modified="2011-10-19" version="1">MADYSRPPSGVKLQLTPFKAHVDEQKLQDFKTLLKLSPVAPANYENSHPSVNRRYGTPRDWLINAKDEWLNKFDWRKHENYINSFPNYTATVRDDAGHELTIHFTALFSQKSDAIPLAFYHGWPGSFLEFHQILELLKKKYSPEDLPYHVIVPSIPGYAYSSGPPLDFDFSLENAAEALNNLMVGLGFGSGYIAQGGDLGSMISRYQAAKLESCKGMHLNFSPTARPKNADELPMEKIEQEALTRGLKFREEGMGYSLEHGTRTATIGHCLSASPLALLSWIGEKFLDWSDEDPSLEHILESVTLYWMTDTFPRCIYPYRGVSLPRGRERPYVEKPSGYSFFPKELVPMPKSWVADTCNLVSASIHTSGGHFAAMEKPSELLQDVEEYIKKAWKAPSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4M5</accession>
    <name>F9X4M5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_36755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855097.1">
        <property type="nucleotide sequence ID" value="XM_003855049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4M5"/>
    <dbReference type="STRING" id="336722.F9X4M5"/>
    <dbReference type="GeneID" id="13400039"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36755"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.912"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_4_1"/>
    <dbReference type="InParanoid" id="F9X4M5"/>
    <dbReference type="OMA" id="CNFWANR"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48969" checksum="6D5ECD7B5375FF10" modified="2011-10-19" version="1">MNFEVSDDLKNYLARLDDFIEREIKPLQAQDDNERFFDHRREHARTNWDAGGLPREEWEELLREAARRADKAGFFRFSLPKEFGGQNTDSGRGSNLWMSVIREHLASKGLGLFNDLQNEHSICGNFSDVIMVQHFGSEEQKKELIHGRLAGKVRITFGLTEPDHGSDATFMATKGVKQSDGSYIINGGKMWQTGIHKATNCFIFARTSGKDGDAKGITCFNVPRHTPGLKVESYQWTLNMPTDHATISLTDVRVPASSIIGPAEDGLQVAQAFVHENRIRQAASSLGAAQYCVNQSVEYARKRRPFGKPLATNQAIQFPLVELQTQCEMLRLLIRKTAVDMDTMPHREVEQKVSDKVSMCNYWANRLCTQAADQAIQTHGGWGYSRHYPFEHIWRHHRRYRITEGSEEIQMRKIAGFMFGFMGPKKETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4U9</accession>
    <name>F9X4U9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_91242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855259.1">
        <property type="nucleotide sequence ID" value="XM_003855211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4U9"/>
    <dbReference type="GeneID" id="13400504"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91242"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="InParanoid" id="F9X4U9"/>
    <dbReference type="OMA" id="RETFDCH"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391126" description="Phosphoglycerate mutase-like protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38489" checksum="E6C09D0B0A0C5085" modified="2011-10-19" version="1">MKLSLLGSTALAVSATHVASITVDNKPGYIKYTTVKGYFLQDEPSTNATTFNYVCQVFRNLDIADNRQPTTNFGLINRTYPATEGLCANLTQWQLFSRQVDALNAAAPLNTVYKTIFMGRHGEGYHNSAESYYGTPAWNCYWAQLTGNGSATWEDAKLTSPGVLQAQIAHNFWKHQIKVQKIPYPQSLTEVDQLWNGVTAEDDTAHKKRMLALLDDVFTNDDHTWISFTSHTGTIATLLSVLGHQPFRLSTGAVIPVLIKAEFLPASDALKVEDGAFTTSTWCHNGPPITSLKDVEQGCVCSKTTAALPSLMTQAPGPPGQTAPLNEYTKTTEVEGNSVSTSNVPCEEPTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4Y8</accession>
    <name>F9X4Y8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_91272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855236.1">
        <property type="nucleotide sequence ID" value="XM_003855188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4Y8"/>
    <dbReference type="GeneID" id="13400309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91272"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1224"/>
    <dbReference type="eggNOG" id="ENOG502SH2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276490_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4Y8"/>
    <dbReference type="OMA" id="LAICHIG"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128663" checksum="49F4B26CD546A288" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X538</accession>
    <name>F9X538_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M3A and M3B, thimet/oligopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_38371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854421.1">
        <property type="nucleotide sequence ID" value="XM_003854373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X538"/>
    <dbReference type="GeneID" id="13395608"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38371"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="InParanoid" id="F9X538"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391347" evidence="8">
        <location>
            <begin position="18"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="234"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="742" mass="83285" checksum="29385387F95819B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5F8</accession>
    <name>F9X5F8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_108402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854657.1">
        <property type="nucleotide sequence ID" value="XM_003854609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5F8"/>
    <dbReference type="GeneID" id="13400886"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108402"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040960_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5F8"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="312"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89633.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5I2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9X5I2">
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    </dbReference>
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    <dbReference type="GeneID" id="13404051"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38865"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.254"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="F9X5I2"/>
    <dbReference type="OMA" id="VKLNIFM"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="129" mass="13643" checksum="397A59BCCA2995FB" modified="2011-10-19" version="1">MPAKQVVLTKNAPPPLAGVLNQAIIANGTVYCSGQVAIDPATGKMVEGDIGARTHQVIKNLDAVLTAAGTTIENVVKVNVFIADMKDFAAMNEVYQTYWGDVKPCRTCVAAKQLPLGTDVEIECIAVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5J8</accession>
    <name>F9X5J8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853718.1">
        <property type="nucleotide sequence ID" value="XM_003853670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5J8"/>
    <dbReference type="GeneID" id="13395728"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91505"/>
    <dbReference type="HOGENOM" id="CLU_2075015_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5J8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="13169" checksum="6F15650E0ECFF44B" modified="2011-10-19" version="1">MPKVPWMRRTWPGVWVLLGVASIASTVTVSAWVARMSSTSLSYTSRWTFETSTMALWSFTLIAAPYHQLSCFQSLTVWSTVAAECHSALAWYMSHAATQEHALRSSLSTHELDGPCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Q9</accession>
    <name>F9X5Q9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine protein phosphatase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MgPTP5</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_39685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854393.1">
        <property type="nucleotide sequence ID" value="XM_003854345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Q9"/>
    <dbReference type="STRING" id="336722.F9X5Q9"/>
    <dbReference type="GeneID" id="13404205"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39685"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="InParanoid" id="F9X5Q9"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28499" checksum="3850A8892B5CF0DA" modified="2011-10-19" version="1">MATELPSPPFVEVPGIHNFRDISDGSHVKTGLVFRSADPTKATEDGLKKMSSDLGIKKIFDLRSHQEIQRDGPEWAGVEREWVPVFATQDYGPEQVAVRYKHYTSGHPDGFVTAYRDILKAGPSAYGKIFRHLAQPEPTPCLVHCTAGKDRTGVLVALLFLLVDVPKEAISQEYSLTDQGLAPLKPLFIERLLKNPALEGNRDGVLNMVSSKKENMDGTIDMILKEHKSAEEYMRTQCKLSDAEIEQLRKNLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X642</accession>
    <name>F9X642_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_38315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854529.1">
        <property type="nucleotide sequence ID" value="XM_003854481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X642"/>
    <dbReference type="FunCoup" id="F9X642">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X642"/>
    <dbReference type="GeneID" id="13404076"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38315"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.305"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="InParanoid" id="F9X642"/>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000056">
        <property type="entry name" value="Sister chromatid cohesion protein Eso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853925.1">
        <property type="nucleotide sequence ID" value="XM_003853877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6Z0"/>
    <dbReference type="GeneID" id="13395531"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70069"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="F9X6Z0"/>
    <dbReference type="OMA" id="TWMQFYA"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="55284" checksum="73B9EE827DCC23E8" modified="2011-10-19" version="1">MSLLTDTRAILLLLVVLPLLIISYQVISDPLRSIPGPLLARFTRLWELYQVIKGDFEKTNIRLHRKYGPVVRLAPGRYSVDDESALKVIYGLGSGFTKSSFYTAAQDVDQHRINLFAERDPQVHLTARRKVASLYSMSNLLSYEPFVDQMNDLLCSKLTLHVEKGSPVNIPTWMQYYAFDVIGEMTIGKAFGMMERGHDSMDILDAIDGGIRHASRFGLFPELHAPTIRAMKRLGVSSDMQGLTAFIGARIQERAVGKTESNREDFLTKTMKLIDMGSIDLSNQFGVIGANIAAGSDTTAVSLSAVIYYLLRDPACAQKLRNEIDSFDREGKLSARATFKETQDMPYLQAVIKEALRMHPATGQVLDRVVPPGGSQICGYFFPAGTCVGANAWTVHRNQGIWGLDADKFRPERWLESSKEELSRMNEGYMPFGLGSRTCIGKNISLLEMSKVITQLYRRFEFDYPDPAAPTDWKTNNVFFVKQSFACRVSPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X776</accession>
    <name>F9X776_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853785.1">
        <property type="nucleotide sequence ID" value="XM_003853737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X776"/>
    <dbReference type="GeneID" id="13404124"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91624"/>
    <dbReference type="eggNOG" id="ENOG502ST09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235895_0_0_1"/>
    <dbReference type="InParanoid" id="F9X776"/>
    <dbReference type="OMA" id="HFKADHT"/>
    <dbReference type="OrthoDB" id="3649400at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="224" mass="26262" checksum="C0B49F2B6CBBD114" modified="2011-10-19" version="1">MTTSTTQPEIFSRDHTLSEEEDTPDIGIEDMQSEEHESEEGFEEEPPYSAQELGEMFTDFYRFLATLHYDPQNLKVPPPEGWNITDLPPSVVEKKSELMVKVMRHLPYFSNARKSTQVDLQCILIDYIDAEQHELCPGREVWLATTSKAHEVSAREERGGPITEKEVRAQEEDWGTELDELFVKQMWRQYGWPEAFRREEAVEAMEAFMAFHTKRRYGWQEAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7A4</accession>
    <name>F9X7A4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_70110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854328.1">
        <property type="nucleotide sequence ID" value="XM_003854280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7A4"/>
    <dbReference type="STRING" id="336722.F9X7A4"/>
    <dbReference type="GeneID" id="13404281"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70110"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.738"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="InParanoid" id="F9X7A4"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP89304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="392" mass="42590" checksum="8FCF18B219374C77" modified="2011-10-19" version="1">MPPQIKQDLNRSGWETTDLPSVCERCLSDNPYVQMLKEDYGAECKLCTRPFTIFRWKADRTARQKRTGICLTCARLKNCCQCCMLDLSFGLPITIRDAALKMVAPGPQSEVNREYFAQNNEREIEEGRGLEGYEKTDEKARDLLRRLASSEPYYKKQRRLEAENAEEAGQKLLEGGESSEGHKPGPIRTQKSAYGSAYGPLSSRGGASSASSRGGRGGARGGKGFPSAAALPPQPKDILPPADKNVTSLFITGVEDDLPEHDLRTHFSQYGALRSVVCSHRSHCAFMNYMDREGAEAAAAACQGRAVVKGVPLRVQWGKPKPMDNMDRETRVANAQAGRGVERSRGDGGNAAGKRAITSGSEQAGEEQLDGLDMVAPPPGQGDVEYAAMAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7N2</accession>
    <name>F9X7N2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_85040</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853696.1">
        <property type="nucleotide sequence ID" value="XM_003853648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7N2"/>
    <dbReference type="FunCoup" id="F9X7N2">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7N2"/>
    <dbReference type="GeneID" id="13404035"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85040"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="InParanoid" id="F9X7N2"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="PHI-base" id="PHI:10788"/>
    <dbReference type="PHI-base" id="PHI:4943"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="22">
        <location>
            <begin position="335"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="20">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="644" mass="71619" checksum="A851EF075DF3B5B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Z5</accession>
    <name>F9X7Z5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="2 7">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HAG2403</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_70219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 7"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854292.1">
        <property type="nucleotide sequence ID" value="XM_003854244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7Z5"/>
    <dbReference type="FunCoup" id="F9X7Z5">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7Z5"/>
    <dbReference type="GeneID" id="13404324"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70219"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="InParanoid" id="F9X7Z5"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="9">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="10">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="499" mass="57007" checksum="1948629F02D3E1AA" modified="2011-10-19" version="1">MSSDSIEDDEDLAQEKQLVNEWSSNSNECLNIRLVRGNGSVAVSCNPEFTYAMFGEEEAIFGYQDLNINLSFRAHDLQPKLDITYGKIFPVQGEVRPTDIAKALSDFLPESAFDNQELGVEADFGPPGEKIHDYKRNGKAYEVWCASLADPAAKKLLENMQILVPFFIDGGSVLELEQDWTTQRWKIFLVYEVDGQANGISPYTLAGYGTSYRCFTFPERQKAPNELSHISDFESPLDLPSRERLSQFLLLPPFRGAGHGQELYKVMYKHLTSPDNIREFTVEDPNETFDDLRDFCDLLYLRANVPEFAALRIHTDIPTEKMASTASIPTDLIVPIDQRKEIMRRTKLMPRQFDRLVEMHTLSFIPTSNRSRNRITRKEKTTNEHDRQYYFWRLYVKQRLYIFNRDQLAQVEHAERVEKLEGALDSVLEAYTEMIERVQTKEEDIANGQVDGDAAPSTAGATKRKRKVVEEDEDEESESGAEQDEVAPSTNGHKKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8Z1</accession>
    <name>F9X8Z1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_109061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LisH"/>
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        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
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    </dbReference>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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        </source>
    </evidence>
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        <submittedName>
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    </gene>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
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    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="58032" checksum="8F387E464BC875A2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9U9</accession>
    <name>F9X9U9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CYP-68</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_92926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853194.1">
        <property type="nucleotide sequence ID" value="XM_003853146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9U9"/>
    <dbReference type="GeneID" id="13399560"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92926"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.896"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044612_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9U9"/>
    <dbReference type="OMA" id="SFETMWR"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="438" mass="49307" checksum="067D19268E1FB2AC" modified="2011-10-19" version="1">MIQVIKFFIRASGQVFARTSEGVVWICRGIQAWLQLSLRQDKVKLTDSAGCRNIIQAKVVQRPGSEAQLKNLIPPFESRAKPNKRLVHAFGINNCFTTAEPQRCTTFRLEATRLIRLRGPEWKELSQTVLQVVKHSVPLQTQAKSNLFNLMQIVTMKSILGPLCGFDSSRSDVDGELQTLAKEINRQWLDSKEGLEKETEFANQPKLKSALKAIAPTWDGLDDTHNPLNFILPGYETLWRVVLRGFLEVMYRANERDSANWRHALEDFALNPTLAQLDKVHTDYGKVSTCMIVEETLRLYPPTRRIYRTFKVAEDEEFEAAADIEGLHRSAAAWGNDALFFNPSRWADKVNDTNFRNDNFMPFGTKPFTCVAKTGLVNEAREKCLPFGVSIIAILLGCFSAEVPAGMTPGGGGADGTWSTDQPLKTGREDYRDVMIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Y2</accession>
    <name>F9X9Y2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_92250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852804.1">
        <property type="nucleotide sequence ID" value="XM_003852756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Y2"/>
    <dbReference type="STRING" id="336722.F9X9Y2"/>
    <dbReference type="GeneID" id="13397125"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92250"/>
    <dbReference type="eggNOG" id="ENOG502SNPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406641_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9Y2"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="493"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="676" mass="74992" checksum="1523CC4EB8F23F9A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA02</accession>
    <name>F9XA02_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_104260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853321.1">
        <property type="nucleotide sequence ID" value="XM_003853273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA02"/>
    <dbReference type="FunCoup" id="F9XA02">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA02"/>
    <dbReference type="GeneID" id="13399989"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104260"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.632"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="InParanoid" id="F9XA02"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="98"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="414" mass="44834" checksum="549C01041227D31A" modified="2011-10-19" version="1">MSLTLLSRRVAVRSVRSSTSASPTCTRAFSTPVDDSFAPISATPPPPPESTNAVWNAVNARAPRYDWTKDEIREIYNTPLMELAFQAGTLHRRFHSPSAVQMCTLMNIKTGGCSEDCSYCAQSSRYNTGLKATKMSPVDSVLEAARIAKSNGSTRFCMGAAWRDMRGRKTSLKNVKAMVEGIRGMDMEVCVTLGMIDQSQADELKTAGLTAYNHNLDTSREHYPSVISTRSYDERLQTLSHVRNAGINVCSGGILGLGEKPEDHVGLLYTVSNLPAHPESFPVNALVPIKGTPLGDDPSRKRIEFDAILRTIATARLVMPATIIRIAAGRTTMSEAEQILCFSAGANAVFTGEKMLTTEAVGWDADKAMFQKYGLTGMKPFERGAYKGSSFAEMRGDAAVPSDNAAPVESAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAE8</accession>
    <name>F9XAE8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_71522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853262.1">
        <property type="nucleotide sequence ID" value="XM_003853214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAE8"/>
    <dbReference type="FunCoup" id="F9XAE8">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAE8"/>
    <dbReference type="GeneID" id="13399779"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71522"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.736"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="InParanoid" id="F9XAE8"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="468" mass="52107" checksum="348239A8FBFCEE0C" modified="2011-10-19" version="1">MDEIAPEYDVVVLGTGLTECILSGVMSVKGKKVLHMDRNDHYGGEAASVNIEALFKKYGNYEKGTEPWKKYGRANDWNIDLVPKLLMANGELTNILVSTDVTRYIEFKQVAGSYVQQGNGAKATVAKVPSDATEALKSPLMGLFEKRRAKNFLQWVGGFDENNPSTHNGMNLSQTTMKQVYDKYGLEATTRDFIGHSMALYTTDDYVDAKGMAKDCIERIRLYVNSMARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTNVDEIKYEGGKVSGIKATMKERGEEGEGMKFETKCKKIIADPSYFPDKVRVTGHILKAICILNHPVDKTDNSDSFQLIIPQSQCGRKHDIYIAVVGSNHNVCPKGYYIAIVSTVAETEANQHLELKAGLERLGRIEEQFMGPPIPIYEPLESGAKDNVFISKSYDATSHFESMTVDVRDVYKRAEGEELKVEGLKEGQGLEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAI3</accession>
    <name>F9XAI3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_42715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP86998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852022.1">
        <property type="nucleotide sequence ID" value="XM_003851974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAI3"/>
    <dbReference type="STRING" id="336722.F9XAI3"/>
    <dbReference type="GeneID" id="13393812"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42715"/>
    <dbReference type="eggNOG" id="ENOG502R8K2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030357_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAI3"/>
    <dbReference type="OMA" id="TGIDTCL"/>
    <dbReference type="OrthoDB" id="4114509at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48243" checksum="56ACB1B7CE4F51FF" modified="2011-10-19" version="1">MASQIQADYLIIGAGAMGMAFADTLLSDTQATFAIVDRYARPGGHWTTAYPYVRLHQPSQFYGVNSRNLGEDRLDQVGWNKGLSELASVDEVTAYYGIVMDQTFLPSGRVQYFPLHEYTGEGQWRSNVTGKSYQVGKQTIIVDATFMKVKVPSMGPPPYKVGEGVELVTPNDLPKATRPYAAYTVVGAGKTGIDASSINAINGSVMEASSPEDLFLRLEKHKQLIRMTDQVWPSMFRCATVSLAELEQVQKIGNVIRQGRVVSLEANKVTMENGDYQPGPDTLYIDCSADALAKLEPVPVFRGKQITLQSVRYCQQVFSAAFIAHVEATYDDEKLKNDLCHVVPHPDESIDWFIVTLQSHRNGPKWSAQPKTAAWLAQARLDWFGKLLPPAPSDPEQVPAFWAAFGAQVQALCEKLEILIGQLPEKDAARAKAQIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAL6</accession>
    <name>F9XAL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_109342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852042.1">
        <property type="nucleotide sequence ID" value="XM_003851994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAL6"/>
    <dbReference type="GeneID" id="13393803"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109342"/>
    <dbReference type="eggNOG" id="ENOG502SNHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371807_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAL6"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="748" mass="84185" checksum="6CBB975807BD1E25" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBC3</accession>
    <name>F9XBC3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_93101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852119.1">
        <property type="nucleotide sequence ID" value="XM_003852071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBC3"/>
    <dbReference type="GeneID" id="13397021"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93101"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.220"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564070_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBC3"/>
    <dbReference type="OMA" id="HRCATIP"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="484" mass="53686" checksum="8CC8073382332DDC" modified="2011-10-19" version="1">MPKEAKSSSKQHRSDPLARPEVPTFTCISCLENFTAQPVMVMQDSMCEKCFTDNMVPQFHLALANEINAPVRYGGVELSIDPYVQYFSEDFLLSWREKAVERQVLEPNRLYCAGAVVNDGEQCNKFLGDKNLHQSALPCARCGSLTCGECRDKIISDPHTCSDPDPDVAPAIPGLKLGVDYQRCPNCRKPIELREGCNHMSCDCLAHFCFLCGQLGLPSNLDIVQPAHLAQEGDQTWGRVSHWGGNSCPLYGPRNQEGQPIFDRPPPEEPDDLDSLWLFTRMLDMMYDRLETLPEIQAAPDPDAAVEAMLDLVLPNLHEAILQTLPALVMLDHMTAMDAVVREFGVHLYACVRNGTDPLDWMQAVADVANLLLNCDSVYVRSLINVQGLRIGEEHWAPLLPEVLRALEGMVHRIGPRGFALFPFLQTVVAGFRLAAQGDYLGLVALPDLGDRANLQPQRDALDEEDRLQLMDPGGDRYPGPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBE1</accession>
    <name>F9XBE1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metalloendopeptidase</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852266.1">
        <property type="nucleotide sequence ID" value="XM_003852218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBE1"/>
    <dbReference type="GeneID" id="13394041"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93357"/>
    <dbReference type="eggNOG" id="ENOG502S2ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842051_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBE1"/>
    <dbReference type="OMA" id="DHEHARP"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033110036" description="Metalloendopeptidase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="36446" checksum="33EE067B9DBA0A9B" modified="2011-10-19" version="1">MNPFLPLSVALSILCYPLIFYLPEPDGLAMLRWDLRWYLIGPPIEKPRIKSTWPVTTLNVQPIRYCFVAESDYDTLSALLTAAIKKWDLAISQSALQIIPDQLPTSPDDHHLCSDPNVSEDALQIEDVTDEPNPYSIGSFTVVGYLGDDAYHTIDFRRQHGRSDGSRGVQEEDAIAMAHELGHAIGFAHEHSRPDAAEHIDFYCDHLPDFEEVMYKIWAYGNQDTIEEACTNRTIAEKYHFSARNWLAHSPPYGKVDQLLWSTPFEVDSIMIYPSDVFGDRFLPVILRKDGSVVKMAGGKGEISAGDAARVAMLYPKRNLFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBH1</accession>
    <name>F9XBH1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_72410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852280.1">
        <property type="nucleotide sequence ID" value="XM_003852232.1"/>
    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="371" mass="40502" checksum="6830A0EA6C2B844D" modified="2011-10-19" version="1">MRSAILTVSLASAVAGAATGYPGQHTSPPETHSQWSLQKFTSLVTFGDSYTDDSLLQYFADHNGSAPPVGYVNPANYHSASGGRPWPQYVKQYAPGGVNLYNYAVAGAVCSNNITPRILDTGTASFLFPAIEQYEVPAFIADAAYTLPDGSPFMINPPDETVYAIWIGTNDLGQAALLTDSQVKGTNIVNYTDCVFNQMKSVYDQGGRYFVLMNIAPLNLVPLYGLPEAGGVGNTTSLWPNKGDNLTYYSYRMEEEVVSVNEIFDYKTPFLTKIAETFEGAEVAIMDMHGLISDMYYNPSEYLNGTAPLNVTGFSHQCDVKGANCVDSDSPDSFLFYDALHPGEQAERVFAREFLDVVNGCGRWATYWSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="99"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="652" mass="66175" checksum="84DEE59617201D81" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SCKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673018_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCE6"/>
    <dbReference type="OMA" id="PIMDSNT"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="157"/>
            <end position="174"/>
        </location>
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        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="409" mass="45554" checksum="D8043C62EC7F8B03" modified="2011-10-19" version="1">MTRSGEHVTRRASCLLHLRLHLRLLVSNLDFLNDSHHRHGGHSRDMSVTSRDHEDHDGAEVAEVLLASSDESLSPEDPQDNSDEQDAAMPSSPPQSKEGMSQPQEVMGPPKISASQARKRTRDEMAMADQDQSSSALPGAINASPVYQDEHFRVSRDTSATIRQDTQTQSTQSYHDAPLTTPCPPESRPPSGQGDNIGLKASALPSHPQQPKVTAASVSSHTESDLGESEQESDASSSTRSSRPEERIQAFDWDELLIQYHEKMNKATAEEHGILKEFRELSKYFNVWAQTGCGKEVDRSFKRLKTQQAYVQNEERQLEEKRVHSFADLFHPGERWTTTTVRIHSANSIQDANEQADAPESTAPKEQHHYASGSNVSAQLTSWATRLSTTADVEPHFRSSYHPARCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ6</accession>
    <name>F9XCQ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_93701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCQ6"/>
    <dbReference type="GeneID" id="13393722"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93701"/>
    <dbReference type="HOGENOM" id="CLU_1788356_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCQ6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="16171" checksum="9CE5E9D9F5837BA1" modified="2011-10-19" version="1">MVFAAAVSLTWDFQRVSFAIEDVALHLREEEPFVCHPRGPTDRGTTGGPKDRVWERCREFQETSDGTTRGPWRGRLHHMLHMQCEVVDWDAGGVSVHHGIADLREDPDPTVGGEARQATNVQECLGLSSQATLVSPLGPWKTRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD62</accession>
    <name>F9XD62_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_93828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851453.1">
        <property type="nucleotide sequence ID" value="XM_003851405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD62"/>
    <dbReference type="STRING" id="336722.F9XD62"/>
    <dbReference type="GeneID" id="13401436"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93828"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016460_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD62"/>
    <dbReference type="OMA" id="HEAEYTH"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PHI-base" id="PHI:8337"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048023">
        <property type="term" value="P:positive regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="PHI-base"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="PHI-base"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="504" mass="54350" checksum="40416A74F755B0ED" modified="2011-10-19" version="1">MSAQPQPPAGANQQYPSSFDQTGQVAPHGMKPRVTATLWEDEGSLCFQVEANGVCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKTRHVVKIGPMHLKGVWIPFDRALDFANKEKITELLYPLFVHNIGALLYHPSNAARQSVGGAAMASAARRSDQQDYMRTPQGSQPPTLTHHHSMSTPGGGSMPQPPHSIAPHPASGRPGLDRAHTFPTPPTSASSLNMNMGHQGSSYGYGEQNGAIQSAATPPNHAQGIQYQTSQAPYDSQRQMYAPAPGAYGQQYAQQPSMNRYGQMQTSPDGVKSEMGPPARAGAENENAEAKPHGGYGGQHDVEGEHEGEYTHSSASFGARRPTYDYNPNPASGPVHTDPSHISPEMTHSPHQNGSGRATPRTTTTYAGYNTTTQRPTQLPQSNLNYVMSNDTRAGAPNGADTGYQPAYQASQYAAMNGTPVANNKRMREDESEDPYGRPPSANGDHKRQRTDSVSTRPIAQPQSLKAGGMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD91</accession>
    <name>F9XD91_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_44003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851472.1">
        <property type="nucleotide sequence ID" value="XM_003851424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD91"/>
    <dbReference type="GeneID" id="13401531"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44003"/>
    <dbReference type="HOGENOM" id="CLU_3093021_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD91"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="54" mass="6343" checksum="BC931F079B482414" modified="2011-10-19" version="1" fragment="single">PTLDIILSRLPNPAHSEFNGITKLLYTFILEHVLTTKGKEEYRRTLRRFVYPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDD6</accession>
    <name>F9XDD6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_73131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851500.1">
        <property type="nucleotide sequence ID" value="XM_003851452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDD6"/>
    <dbReference type="FunCoup" id="F9XDD6">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="GeneID" id="13401559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73131"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.349"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="F9XDD6"/>
    <dbReference type="OMA" id="YDYKDAQ"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="345" mass="36892" checksum="DE14C8F27FA888AF" modified="2011-10-19" version="1">MSLPSTMKAIKILPDHKAGLKDVPVPKLRDGYVLCKVKAVALNPTDWKHIDFVGKEGSTVGVDFSGVVEEVGSGVTKTWKKGDRIAGFVHGGNEAEPEDGAFGEYCVVKGDIAFKIPDSMSFEDAASLNTGVITCGQALYQSLGLPLPGSGKYGGYLLVYGGSTATGTLAIQYGVLSGAKVVATASKHNWPLLKSLGAEEVFDYNDPECSKKIRAHTSDTLTLALDCIAEGNSPKICEEAISTKGGAITYLLPTQHTRSDVENKQTLGYTITGEEFNKFGKHFPASQEDFEHAKMFWALSEKLFHAGQLTPHPVEARKGGLDGVFGGLQDFRDGKVSGKKLVYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDJ5</accession>
    <name>F9XDJ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_44256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851816.1">
        <property type="nucleotide sequence ID" value="XM_003851768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDJ5"/>
    <dbReference type="STRING" id="336722.F9XDJ5"/>
    <dbReference type="GeneID" id="13401590"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44256"/>
    <dbReference type="eggNOG" id="ENOG502SUB0">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125541_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDJ5"/>
    <dbReference type="OMA" id="YFRNSKH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15346" checksum="9EC3383E602CE7D8" modified="2011-10-19" version="1" fragment="single">MSCLSEGAEFISEAGKTYLAVSSLGQSNVWTAVEKDDMSNIVVLKAPSDNDIPGQWPRFQHEMIMHELFKNSKNIRRQVDRIPPTPEGSPPILVLEITETTLWGARTKRPFSRGEIVATMKGILLSLQEVHEHGLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDM0</accession>
    <name>F9XDM0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_43911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851803.1">
        <property type="nucleotide sequence ID" value="XM_003851755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDM0"/>
    <dbReference type="STRING" id="336722.F9XDM0"/>
    <dbReference type="GeneID" id="13402167"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43911"/>
    <dbReference type="eggNOG" id="ENOG502SCRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175850_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDM0"/>
    <dbReference type="OMA" id="MCKKASC"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="56" mass="6154" checksum="87D9BCC6C9994EA5" modified="2011-10-19" version="1">MCKKAVCGTCQKTSWWGCGQHIPMVMDPVPAADRCTCEPKVEREGKSYPPMGKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XES3</accession>
    <name>F9XES3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_81437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851260.1">
        <property type="nucleotide sequence ID" value="XM_003851212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XES3"/>
    <dbReference type="GeneID" id="13401092"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81437"/>
    <dbReference type="HOGENOM" id="CLU_1691072_0_0_1"/>
    <dbReference type="InParanoid" id="F9XES3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="156" mass="16513" checksum="C6FBFC1006A143D3" modified="2011-10-19" version="1" fragment="single">MESVDEYLSSPCITVGGDVERKPSDGGVSQISTDVPADDAPSDPTAVGQSLRRRGKSFGGMLNKQIRPLELAPDTKPSFTAPKHSRSFTVTAAADKKPSLPGTQTSGPAPARHSISLALTSNPFVPSDEDLPQQKAHSEQLVSDKEETSDPDQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG39</accession>
    <name>F9XG39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_22047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850750.1">
        <property type="nucleotide sequence ID" value="XM_003850702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG39"/>
    <dbReference type="FunCoup" id="F9XG39">
        <property type="interactions" value="1019"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG39"/>
    <dbReference type="GeneID" id="13397488"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22047"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="InParanoid" id="F9XG39"/>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140530">
        <property type="term" value="P:MCM complex loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="87"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="511" mass="55295" checksum="A98A4B34C05EF100" modified="2011-10-19" version="1" fragment="single">TPTTPRHRNALSKKIPVTPSRHGTLFARGQLTPRSPRTPRTPGTAASVYNQARQIFARSSNPGKLVGRDEERAQLSEFISTASAAKSTGCLYVSGPPGTGKSALLDEVIREHTEDGKIPLSVVNCMSVRNAKDLSQKLAEDLDLQEEAGFDYLKSCFVRGKARDTQKYLVVLDEVDRLVDLDLGLLYSLFEWSMMPSSRLILIGIANALDLTDRFLPRLKSRNLKPELLPFMPYSATQIAEVITSKLKSISTVDADTVPFLHPAAILFCAKKVASQTGDLRKAFDICRRAIELIDNEVRSKELVAADSPSKLPLGENLNLSSSPSKPQPILYTVSTAPKATIAHMAKATSQAFSNGAVQRLSSLNLQQKAVLCALAATEKRAQEAEVPWAAPSTPSKSQTYAPTIKALFETYTTLCKKEHLFHPLSSAEFRDVVSGLETLSLVSAVEGSGKGGSFGALMTPVKTPGKGRKGGWATGTVGDERRMKSAVGVKELMSVVEKGVAGELLREMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG75</accession>
    <name>F9XG75_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850763.1">
        <property type="nucleotide sequence ID" value="XM_003850715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG75"/>
    <dbReference type="STRING" id="336722.F9XG75"/>
    <dbReference type="GeneID" id="13397501"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94585"/>
    <dbReference type="eggNOG" id="ENOG502RYMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2039911_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG75"/>
    <dbReference type="OMA" id="GTNAYPK"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="121" mass="13363" checksum="96AD81DDE8AF02EC" modified="2011-10-19" version="1">MASNNTSAQVTTHDTDHHVHVAKTLSPLFVDDPPVRFILSSLSEEARLAYMDDYFGTLVKAAALNSAEFVEANDWDCTAVWLPPGKRIDNSWTWWSAGFVGCLWKLGVAGCKVSPQLCLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG79</accession>
    <name>F9XG79_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_74170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851077.1">
        <property type="nucleotide sequence ID" value="XM_003851029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG79"/>
    <dbReference type="FunCoup" id="F9XG79">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG79"/>
    <dbReference type="GeneID" id="13397817"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74170"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.489"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="F9XG79"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="706" mass="79266" checksum="8ADF98485A634560" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGB4</accession>
    <name>F9XGB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_105290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850784.1">
        <property type="nucleotide sequence ID" value="XM_003850736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGB4"/>
    <dbReference type="STRING" id="336722.F9XGB4"/>
    <dbReference type="GeneID" id="13397801"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105290"/>
    <dbReference type="eggNOG" id="ENOG502S5XA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2164555_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGB4"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="111" mass="12606" checksum="9542A2DB1C083FF5" modified="2011-10-19" version="1" fragment="single">MAQAQMMQFADTIASMKLALKRRADDSGSDSGIQQRTNRGNKLKRRAKNVQEHRLDDTGGLNWRRPVNHAGYTRKTISSNPPFFDDDGDPYSPTESDYENDRYAEPAEDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGK9</accession>
    <name>F9XGK9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="F9XGK9"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="174" mass="19278" checksum="53E953331DAE54B7" modified="2011-10-19" version="1">MAAHTLVGRGRAHCRAGAPIEPPEEVDAGLNDAYEDPNKQNDKLKKRVGDMKDQMSRMKKRMRDMKNNYEHRFAALEDHTQALQRAAQHFDASVSSSYVPLYRHPASSTTNSATCSRLSTVPSCVSTEIAVHRPDMDTLEPVKREPSTVAHDRASAERSLDCISVGAPTSPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94676"/>
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    <dbReference type="HOGENOM" id="CLU_596132_0_0_1"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP85803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="459" mass="51244" checksum="84613EDC21F60867" modified="2011-10-19" version="1">MSDPHRRNPTELGGHFDSLPEVSGANLPEQLQNTQTTTSTTRRSAFGDYRNDLIGPRSNNAPHRSTMLYAPLTNNSNAVYDTSRQEHTALTRGQLLTSEEMRRSGRPVAPLVRRRDVAASRGQELPDQDAITRELTSTLRSRLPLERPHVLNPLAPLASGGGGRFTYPALRREAAPSPEDQPQSDGAHQPRGDTLYASLNPSNARRVRFGDQSLVVSPDEPVDAPATANLAPQARPVLPDPLASGTEEDLLETNSEDELEEEEEEPYPHGHPLHVCSVPAYKGPRPHYTTFPILSKIPGYVWTGHAETDAALKLQYNRRIEFMFGDCVICRQEFDNGWETICEHITCTSCMLKCHSLRGVCPLCNQEISLDPKGGTFLRKWKAEYGRHGEDPVKLAEIKYEQQKTMILEKDPGARWELWALEAKQERDKLEKQLAAIVPIGGRFPDGTIRRGILGIDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGT9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
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        </location>
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        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85455.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="89726" checksum="C781F0FC387EB442" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH13</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850157.1">
        <property type="nucleotide sequence ID" value="XM_003850109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH13"/>
    <dbReference type="GeneID" id="13394598"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95397"/>
    <dbReference type="HOGENOM" id="CLU_1086680_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH13"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="28348" checksum="0131D70EF111D0BA" modified="2011-10-19" version="1">MGDVEDSEEEDDEEEEEEEGDSDDEEDGEPDGGLEEASEPPTKRAPEYGRLRCREWNVPLHQLFTTFHRFPTTFPADRNMQPSSEHEIQQLKARVKTLEDEVGHLHEMMRQLILQALPNAISPTSTEVRGDAAARHDTSSPTRGPATSTQKAAASLLVLFRDREISTPTTSIYYATTEHFTGEDATSLESSEIIPGHMDADLLPASDFNPESGRVSPPLAREGSPPLLSRLWTAFWSDGSPATGRRSMALSLIQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHR8</accession>
    <name>F9XHR8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_46959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850552.1">
        <property type="nucleotide sequence ID" value="XM_003850504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHR8"/>
    <dbReference type="FunCoup" id="F9XHR8">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHR8"/>
    <dbReference type="GeneID" id="13402688"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46959"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048162_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHR8"/>
    <dbReference type="OMA" id="DPVCGYE"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="37129" checksum="54981EEED63C1F6E" modified="2011-10-19" version="1">MPKRSAPHDHDFSVPPSKKRRDSLPRWKPDTPLARVPAYRDYIPADTSIPPLPTIDSEPLAEAPFRHKSAFSSDRTEASNDMSYERLEFLGDAYLEVFASRLIFSRFNQLPAGQMSQLRELLVKNETLAEYGRAYGFDQRVKVADLEMMKQSCKDKAGNKALNKVIGDVFEAYIAAIVLSKPETGFAEAEEWCMRLWESKIQATTEDKLHEYNPRAKAELQQRILYGDVKLQYEPWKPTVELKGDRIGQNQHFIALYLTGYGYERKLLGKGVGQNKVEAGIWAATEAMHGENKSLIDDCEAQAKEAKEKRQRAQAEKDLTEKSSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIC3</accession>
    <name>F9XIC3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_74429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849910.1">
        <property type="nucleotide sequence ID" value="XM_003849862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIC3"/>
    <dbReference type="FunCoup" id="F9XIC3">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIC3"/>
    <dbReference type="GeneID" id="13395155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74429"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.103"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="InParanoid" id="F9XIC3"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12436" checksum="7BE09E95F35155E3" modified="2011-10-19" version="1">MSESQGHRLYVKGKHLSYQRGKRNTNPDTSLIQIEGVENTKDATFYLGKRIAYVYRAKKEIRGSKIRVIWGKVTRTHGNSGVVRAQFRHNLPAKSFGAMVRIMLYPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIE8</accession>
    <name>F9XIE8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_74468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849922.1">
        <property type="nucleotide sequence ID" value="XM_003849874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIE8"/>
    <dbReference type="FunCoup" id="F9XIE8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIE8"/>
    <dbReference type="GeneID" id="13395142"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74468"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.132"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="InParanoid" id="F9XIE8"/>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042736">
        <property type="term" value="F:NADH kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47378" checksum="98DC086EA5C493B7" modified="2011-10-19" version="1">MRTIRIWRNFNQLLNKKRCFHYSAVRHDIKSLEELPSRLQPQFKQTSNHDLLALTWPSPPRNVLIVPKHNDADVQSAVIEYANHIHNVYPGSSLIFEPTIANQLHERFDFPIYAPPDSSSNALYQDKVDLTTTLGGDGTILHAASLFATSPSVPPILSFSMGTLGFLGEWKFAEYKRAFREVFVSGAPPPISSSEPPTSPPSQWGDVRGKSMGASRNSRILLRNRLRIGIFDSATGERLPHDPPSSSSNSDIYALNEVLLHRGALPHLAHITILIGSPPHQRPLTTAIADGFLVSTPTGSTAYSLSSGGSIVHPLVSSLLLTPICPRSLSFRPLVLPANTPITLRIESSNRGKEIEVSVDGIRRGEGLREGMEVRVVGEEVRQEGKERGEKDWLRGVPSIVRSGGDGASGDDHWVGGLNSLLKFNYPFGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIR9</accession>
    <name>F9XIR9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850144.1">
        <property type="nucleotide sequence ID" value="XM_003850096.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIR9"/>
    <dbReference type="GeneID" id="13394694"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110582"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.617"/>
    <dbReference type="eggNOG" id="ENOG502QVDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001347_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIR9"/>
    <dbReference type="OMA" id="KMWTITA"/>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1455" mass="159149" checksum="EE99D2C067D209B4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIZ1</accession>
    <name>F9XIZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_75295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIZ1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.58"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIZ1"/>
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    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="cinA"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
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    <dbReference type="InterPro" id="IPR001453">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="49"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="324" mass="36061" checksum="61FDE565A3D35BC5" modified="2011-10-19" version="1">MFSRLSQLTRHLSKPLPNYLHQSSFAGAYTSRTLAMAEERSKRTIHTAACLIIGDEVLGGKTVDTNSAYFAKFCFSLGINLKRVEVISDDEGEIVEAARRMSSNYDFVVTSGGIGPTHDDITYQSIAKAFSLPLVLHEESYKKMKALSKPRPDQPPFSWDEDSPQRRAKLRMIELPYDNSLPDADQVIFPAEDLWVPISCVNGNVHILPGIPRLFEKLLTGLKPRLLPRLTDPDGKGVHRILFSTPLPESSVAEFLTQLAAKVEPKGVKVGSYPRWGKSRNTVTLVGKDKEFMETLIEEVEKGVEGKRVQAEDENDSEGSDKDA</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95546"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.88"/>
    <dbReference type="HOGENOM" id="CLU_1195685_0_0_1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="232" mass="26012" checksum="640F89AFCFDD8A32" modified="2011-10-19" version="1">MTGLSSKVITTGVRLLASRRNRTLGVCSGILYKGPAQHRCQSTKKPAVAAVKRPNSRTESRSNAQAPASHKQPTDSTDDKFYKYYLYDMPNKPSKIDPTGAWLEWAEFDAGKSSLPVPLRERPLEFFDPLGAPTSGLLDLYTAQLCLERYIAKTAVGRSKEDMREQFASPNDLPGTQALSWLRQDYDRADLSDNVGFLRALVYCLSAEGGEEQVWRWLELEHNPAILSHQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ53</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
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        <property type="component" value="Chromosome 9"/>
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        <property type="entry name" value="AGP_Transferase"/>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="465" mass="52038" checksum="B6AE2DFBC4BA9A6D" modified="2011-10-19" version="1">MNSTPVPTQYGLIWEPEVFGNLSPRWSAEPSISQIKALCRQHLHLDPEEPCTATLHERGGTSIVYTIEALARSPGRWIIKVCLPVDPGRKTRSEVATMQFVKERTKIPVPGVLACDVSNQNSLGFEWNLMDFMPGTELTNVWLGLEFQQKAEVVRQLARYQAELLLLPFDSHMIGSLYPFSQSDNSSGPGTSPYIGPVASHRFSWGPTLSGQQDSNARRGPFKNSHNWLAARLQLIIDHPLEPRSKGTPPADAASQAPSLAHRLLALLPSLFDPEKCGEEIVLHHADLHEGNILISTSERKSTSATEPTIDSDPVITALIDWEHQILSPFWHAISPPCLFDGKVRLSPPLASDYPPEPSSGDGSDNPDNLGKPYAFWQHTQEYEHGLLRSIWEEGMKSHLGEEVWKRVWTSEEARRKSDFELAIWVADGPAEGRRVAIVEEWIGRWERSGWTDGKGLWEELYVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJN5</accession>
    <name>F9XJN5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MgHetC</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_62615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849632.1">
        <property type="nucleotide sequence ID" value="XM_003849584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJN5"/>
    <dbReference type="STRING" id="336722.F9XJN5"/>
    <dbReference type="GeneID" id="13402429"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62615"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_2_2_1"/>
    <dbReference type="InParanoid" id="F9XJN5"/>
    <dbReference type="OMA" id="AFIKGHK"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390704" evidence="2">
        <location>
            <begin position="24"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="592" mass="64387" checksum="027F803D90B8F555" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJQ1</accession>
    <name>F9XJQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_47526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849622.1">
        <property type="nucleotide sequence ID" value="XM_003849574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJQ1"/>
    <dbReference type="STRING" id="336722.F9XJQ1"/>
    <dbReference type="GeneID" id="13402289"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47526"/>
    <dbReference type="eggNOG" id="ENOG502S5YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184135_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJQ1"/>
    <dbReference type="OMA" id="HRARHKE"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8598" checksum="05ABDEC4429A733D" modified="2011-10-19" version="1" fragment="single">MVSTTPSEPSPQARIRDNQRRSRARRKEYLQELETKYRTCEQIGASASTEIQAAARKVADENRRLRVLLQSHGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK71</accession>
    <name>F9XK71_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ASP1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_30154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849722.1">
        <property type="nucleotide sequence ID" value="XM_003849674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK71"/>
    <dbReference type="MEROPS" id="A01.079"/>
    <dbReference type="GeneID" id="13399087"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30154"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XK71"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="29"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="340" mass="36308" checksum="A8DFB121C1FD61BF" modified="2011-10-19" version="1" fragment="single">SSTSRAPTTTASNEDGEATAVPEENESEYLTETTVGGQKVNLNFDTGSADLWVFSSLLSQSALGDHSFYNPNNSDTFESYDGATWQIRYGDGSSASGVVGYDVVDVGGTTVQKQCVELATQLSRAFIADDASDGLLGLGFSTISTVKPVQQKTFFENVMPQLSSPVFTADLEETSGAGTYEFGRIDPAKYHGEIHYTPIDNSDGWWQFDSPSYSVDGQESPCTYCNPAIADTGTSLVYMDTDIVRAYYASVSSAFPDTSQGGWVFDCTETLPSFGLAVGDYMAVINGTDMAYAPLDDGSGMCYGGLQEGPGDVQIVGDVFLKQFFAVFDGGENRFGVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK81</accession>
    <name>F9XK81_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_47732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849714.1">
        <property type="nucleotide sequence ID" value="XM_003849666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK81"/>
    <dbReference type="GeneID" id="13399089"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47732"/>
    <dbReference type="eggNOG" id="ENOG502S23D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120561_1_0_1"/>
    <dbReference type="InParanoid" id="F9XK81"/>
    <dbReference type="OMA" id="HACCAPI"/>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF3">
        <property type="entry name" value="DUF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="136" mass="14819" checksum="AC32E9713F252252" modified="2011-10-19" version="1" fragment="single">LHPFYTTPLLSPLLFDNTDSSARDHLAAERTFLSWLRLAIYMSVVATAILISFHLKHQPSPTERKIALPLGVVFWVLALGCLGAGVGNYVKTVEGYARREAVVQSGWGTQVVFTVVAAAIVAACVLFLSMEVERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK85</accession>
    <name>F9XK85_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_75563</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849711.1">
        <property type="nucleotide sequence ID" value="XM_003849663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK85"/>
    <dbReference type="FunCoup" id="F9XK85">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK85"/>
    <dbReference type="GeneID" id="13402508"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75563"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_1_1"/>
    <dbReference type="InParanoid" id="F9XK85"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="250"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="738"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="766"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="833" mass="92519" checksum="547BFD6CCDE99276" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKC4</accession>
    <name>F9XKC4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_75897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849527.1">
        <property type="nucleotide sequence ID" value="XM_003849479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKC4"/>
    <dbReference type="FunCoup" id="F9XKC4">
        <property type="interactions" value="1114"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKC4"/>
    <dbReference type="GeneID" id="13402386"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75897"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.563"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKC4"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="41261" checksum="38D7BF9133F872AA" modified="2011-10-19" version="1">MNAVDATERGSGQQDGEPPSLLTIILDTNPHAWALLEDSLSLSKVVVNLLVFVNAHIAINHANRVAVLASHSERAEWLYPTAPSSHSHRTNGDDVEMADSTATMNGGANHPPPDDPNKYRPFAQIEHALANNLRKLIERTSTSSLSATPATMMAGALTMALSYISKQSAALPTTTSSAQFNYSDPNAGPAGGNDLAADNKGPNNLLGLTSRILILSVSGDLADQYIPIMNSIFACQRLSIPIDILKLAGDTVFLQQAADATGGIYMALDEQSRAGFLQYLMFAYLPDQTARNHLIMPGESEGVDFRAACFCHRRVVDIGFVCSICLSIFCEPMQDGQCLTCGSHLSMANYGQKPAVVPKKKKKKVPRKGIDGVDTPSSRAGTPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKK3</accession>
    <name>F9XKK3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849244.1">
        <property type="nucleotide sequence ID" value="XM_003849196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKK3"/>
    <dbReference type="STRING" id="336722.F9XKK3"/>
    <dbReference type="GeneID" id="13398791"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96011"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.19"/>
    <dbReference type="eggNOG" id="ENOG502SVYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769891_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKK3"/>
    <dbReference type="OMA" id="ANEIPKR"/>
    <dbReference type="OrthoDB" id="5427925at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390751" evidence="1">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="40365" checksum="13FB97F82DB47219" modified="2011-10-19" version="1">MATLRIFFSFLICALAILSIFPTSIHLVTQTIEIMCKAPLVNHFISCAPSQQFQVFPNPIFANIIAQNVELASMREAASDIAAFPYQLAIGHSDFKDMIFEISAEDLPFKQLLWPLLKSFNKLTDGATDSVQRSVSLTNALIDNTIIVHSWARDKLQLDEAREKSFPSPLPPIARAIGLDYASEDALLQVFTLTTSQLVRQTNHVLVQHEATKESLVELRDLLDRIAFALKPEEHSLKREKLDDASYWKALLSHRSNLPNFDKKMETCARFYDYTLRAGKAVAETSVALHDVRSKVKGVQEEVERSPMSLASSGTSLRQTIFSLGVSIANLEEFQRISRAEQEKRMQTFDSTLDGFAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKR2</accession>
    <name>F9XKR2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848862.1">
        <property type="nucleotide sequence ID" value="XM_003848814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKR2"/>
    <dbReference type="STRING" id="336722.F9XKR2"/>
    <dbReference type="GeneID" id="13398032"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105932"/>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597457_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKR2"/>
    <dbReference type="OMA" id="CKPRETQ"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="47251" checksum="F2D6F2AD60ABA2DA" modified="2011-10-19" version="1">MSTIDARFHQAQEKALATETKAATKAEQPSQEPLSLTEQVQKAASAKHSPAPQQPGLPQPFPPAPSQSPLPAPAAQRAGRQSVADQLQTDSRDRSSTPSVDTPSIAVAPWAKEPAEASRGPSLKEIQEAEAKKAAEAEEVAAAARRAAFQRELEAQAHVNTAPQPGLPTSSTWGAVTPTAGTPTGAMPAAWAKTASKPAGPTASKTLAQIQKEEEARKRKLAAAAAAAQAQASLMGAAPAPAVGKSYATLAGKITIPPVNPNAPGSAWTTVGASGKVKTPGGPAISPASTRTASQGVLPAAASIPAAIASPALVRKAPVSRSASMANPGAVNPHDEFRKWAINELRPDLKKGINVDEFVGTLVILPPESEVITEAVHGVSNTIDSRHFAEEFIRRKRLADKGLVDTSIPKSASPALAADNKTGGWNEVAKKGPSKEPVKEEANGNFRVVASKKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL07</accession>
    <name>F9XL07_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_87682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848771.1">
        <property type="nucleotide sequence ID" value="XM_003848723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL07"/>
    <dbReference type="FunCoup" id="F9XL07">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XL07"/>
    <dbReference type="GeneID" id="13398764"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87682"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="InParanoid" id="F9XL07"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="129"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="485" mass="54346" checksum="1F6A79605A048552" modified="2011-10-19" version="1">MLARQRAKEEAEANGRQAPKGGWFPLGYKDGFSQWWASLTPAVTEHRVMSFIPYLQQPPTHMQTGSTPTSPSASMVQVDKSQEAVQRTSSVNDPYGPRQWKSQMVQLAGKNRYLNEFSVERTGEQTDNNLVMLHGYGAGLGFFYKNFEPLSRLPHWKLYALDMLGMGRSSRPTFKISAKDREAKTREAEGWFVDALEEWRVKKGIDKFTLLGHSLGGYMAVCYALKYPGHLNKLILASPVGIPEDPNAVSEALPEPGDSTLANEFTQDASKQKQPRKPLPGWLVTLWDANVSPFSLVRWSGPMGPRLVSGWTSRRFSHLPAEECQALHDYSYSLFRQRGSGEYALAYVLAPGAFARSPLIRRIHGVGRQFLEAHSEPSPDDATLTAAVANKARENGIPVVLMYGENDWMDVGGGHDSKKRIEAAKKKALDQASDREKQLENGDVKVTVIRKAGHHLYLEGYEQFNEEILGELKDVERRQKRLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM10</accession>
    <name>F9XM10_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_111320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848428.1">
        <property type="nucleotide sequence ID" value="XM_003848380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM10"/>
    <dbReference type="STRING" id="336722.F9XM10"/>
    <dbReference type="GeneID" id="13396244"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111320"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_1_1_1"/>
    <dbReference type="InParanoid" id="F9XM10"/>
    <dbReference type="OMA" id="VVWFSHA"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="495" mass="53173" checksum="ED3A01EB12ABB4D9" modified="2011-10-19" version="1">MAFSIATLWTAPAINPINKKARSIPFFNPINEYGRVFFFSWFGFLLAFWSWYAFPPLLHDIIAKDIHLTPIQVANSNIVALTATLCVRLIAGPACDRFGPRKTFAGCLLIGVIPTFLSGTVYNVNQLYACRFFIGILGGSFVPCQVWTTGFFDKNVIGTANSLTAGLGNAGGGITYFVMPAIFNSLVKDQGLTAHVAWRVTFVVPGIIIAAVALALLLLCQDTPTGKWSDRHQIVESSSLRQHGLQGAIVDIPGSVSEEKEKDQRPASSSASSSKVLDEEEKKLDATRGPTFADNEAQLGSAQMLDTARGEVIQKPSFTTILKLSISPQVLVLGIAYFCSFGAELSVNSVLGSYYQKQFPNLPKETASNWAAMFGLMNVVFRPLGGVVSDLAYKYSGENVWAKKALLHGYCLITGGFLVVIGMVDSHGVGQLVALVGVGMAFFLEGANGVNFAVVPHVHPHANGVVSGFVGACGNLGGIVFAVVFRNLLTMDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMA6</accession>
    <name>F9XMA6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848504.1">
        <property type="nucleotide sequence ID" value="XM_003848456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMA6"/>
    <dbReference type="GeneID" id="13396200"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96844"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.498"/>
    <dbReference type="HOGENOM" id="CLU_1579737_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMA6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="17954" checksum="CD1309DF83284B07" modified="2011-10-19" version="1">MWTTITRTASATLSSISATPTSVCAAAPPAHGFCLPVIEQIRSGVTSLFLVILALVGVKYPRNPKVRFGLALASGVGITTLDGMAIHCVIIDHWPSVIRFFAAFTAMVVELLRDFLEIRAERKAAGCAAKRLEEQRGVESVELAVLGAHTTGLRSHAAAATRMVVSDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XML1</accession>
    <name>F9XML1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgSCP5.1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_76675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.81"/>
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    <dbReference type="OrthoDB" id="1735038at2759"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:dipeptidyl-peptidase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847188.1">
        <property type="nucleotide sequence ID" value="XM_003847140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRH7"/>
    <dbReference type="GeneID" id="13399693"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97827"/>
    <dbReference type="HOGENOM" id="CLU_1939770_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRH7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="130" mass="14368" checksum="DDB0B148EBEA6184" modified="2011-10-19" version="1">MPQVPCLATQGQYNMPSKAQLMQELASANERIKSLETELRGYKIGLARAQALPPSPPASPQPAQASSPQARYFESLTQEQKDQCIKLNICFRCRQHGHSSSHIQCHNNDWRARSREPAATTPAPTPSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS10</accession>
    <name>F9XS10_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846986.1">
        <property type="nucleotide sequence ID" value="XM_003846938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS10"/>
    <dbReference type="GeneID" id="13396701"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98000"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_20.4"/>
    <dbReference type="HOGENOM" id="CLU_1836707_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS10"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="16231" checksum="BAAE02BCE2108CBC" modified="2011-10-19" version="1">MKNLGRRRRVTEPDIISYRLESDELRGPAAYHWFDKTIVFEAADLPSRMDIERFRTGTLLFALKNDVSSHDYSFLRDLDQPPSQSQRRISEPPQPSTPLLSSPHFLGGLKENAYLSGSARWNREVFPKQCFDCAQYYTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS98</accession>
    <name>F9XS98_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846899.1">
        <property type="nucleotide sequence ID" value="XM_003846851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS98"/>
    <dbReference type="GeneID" id="13396656"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106706"/>
    <dbReference type="HOGENOM" id="CLU_3070480_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS98"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="53" mass="5773" checksum="3C76363B21DF1D77" modified="2011-10-19" version="1">MEDPCSWTSGLGRMFAQLSRPRDKSVWAAAIARLASSILSSSVISRDFAVNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5I1</accession>
    <name>A9Y5I1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">atp9</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="17"/>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648752.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5I1"/>
    <dbReference type="FunCoup" id="A9Y5I1">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="336722.A9Y5I1"/>
    <dbReference type="GeneID" id="5846264"/>
    <dbReference type="InParanoid" id="A9Y5I1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000009">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABU40268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="74" mass="7491" checksum="10F1DA5E37E9FA50" modified="2008-02-05" version="1">MIQAAKIIGTGLATTGLIGAGVGIGVVFGALILGVARNPSLRGQLFSYAILGFAFAEATGLFALMMAFLLLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWC2</accession>
    <name>F9WWC2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_65543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857556.1">
        <property type="nucleotide sequence ID" value="XM_003857508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWC2"/>
    <dbReference type="FunCoup" id="F9WWC2">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWC2"/>
    <dbReference type="GeneID" id="13394341"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65543"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="InParanoid" id="F9WWC2"/>
    <dbReference type="OMA" id="FRAGEIW"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="211"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="452"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP92532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="701" mass="76667" checksum="4E64A2D31B151C25" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWM9</accession>
    <name>F9WWM9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_107300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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        </source>
    </evidence>
    <sequence length="354" mass="39608" checksum="243367C77BE393F2" modified="2011-10-19" version="1">MPRKRAASELADDEKEKKFDWPKEIIKELFDAAVVLKDDGKITEAYGFKKTDVEDIRAALNKEHRVWRAYTAHLSHISGWSGPVDGVPRSSKEVEDKHYNANPRCRRFRKNLPLCARQCEYLYSDNLATGNEAFEPDELGGDTPVPKEDWPLSNDSGGDAEGDNDVEEVASRSVKRLKGGGGSASSPAPTTLLASKRIHRKKEPPSDNVDSESQASVTSAAAMALKRVVDSYGITRTRAPQAPQSVLTQSILKCHKSAAFKKLKDEDRFLFIKKILPLDKNAETVKVKQEKEAMLPPPPVVQRTPAPLNPPLPHDYQPPHYYQLPSISEGYGQQQPYSSQVDYWHQQSQSQSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXF6</accession>
    <name>F9WXF6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_98156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855879.1">
        <property type="nucleotide sequence ID" value="XM_003855831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXF6"/>
    <dbReference type="STRING" id="336722.F9WXF6"/>
    <dbReference type="GeneID" id="13403818"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98156"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.109"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="InParanoid" id="F9WXF6"/>
    <dbReference type="OMA" id="SMTQFGQ"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="266"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="459" mass="49709" checksum="3C1E0B03D116FF69" modified="2011-10-19" version="1">MEIKKPQSDAYVLGVGMTQFIKPRQTRSYVELGFEAGAKAMLDAQINYDDVEMGVGCFCFGSTTSAQRIFYQFGMTGIPIYNTNNACATGSTGLHMARTMVRAGAADCVLVVGFEQMQPGSIKSDWSDRPSPMGLSTDLMEETYGKHASPRNAQYFANAGQEYMDKYGAKASDFAEIGRISHKHSTNNPYAQFQKEYTLEEVANSTMIHAPLTKLQCSPTSDGAGAAVIVSERFLAARSHLKSQAILMAGQQLQTDDPSLFSKSAMDLVGFGMTKNAAQMAYKEAGVTPKDIAVCELHDCFSANELILLEGLGFCEQGKAHEMVRNGDITYGGKGPIINPSGGLISKGHPLGATGLAQCCELSWQLRGWANTRHVDAKVALQHNLGLGGCVVINVYKRADGQANKKLTDEEAIKGTAWKYNPATQAKTPSMEEMQVVRSKKASVQYALGDTPEKIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXI8</accession>
    <name>F9WXI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_28780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857749.1">
        <property type="nucleotide sequence ID" value="XM_003857701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXI8"/>
    <dbReference type="STRING" id="336722.F9WXI8"/>
    <dbReference type="GeneID" id="13403836"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28780"/>
    <dbReference type="eggNOG" id="ENOG502S91F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106375_1_0_1"/>
    <dbReference type="InParanoid" id="F9WXI8"/>
    <dbReference type="OMA" id="HANTTQM"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14652" checksum="318D25756E90F389" modified="2011-10-19" version="1" fragment="single">KRPRLTTSTTPSSLLNEEDRLLVHLREDLALPWKEVIARFKSSTGKPFQIAQLQMRYKRLREKYRVWEESDTEALKKAVEEWERCKWEIVSAKVSSLSAMLSYGVEEKWPPGMCGRKWRQLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXL5</accession>
    <name>F9WXL5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_88884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003857611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXL5"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88884"/>
    <dbReference type="HOGENOM" id="CLU_1846712_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXL5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="139" mass="15038" checksum="835BEA93378591CA" modified="2011-10-19" version="1">MMHQARRSTAGICSALGVNILTFGFIISFITVSCSELARSNHPVLSMELSVVYAIWTLLPGTFDGMNLFTHADFMRTLVFIPTGVTGAVMDTEGAEEECLCQICLTDKANVGQLPCGHHGCKECLVLMGHKIQKACPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXV0</accession>
    <name>F9WXV0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_31400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857532.1">
        <property type="nucleotide sequence ID" value="XM_003857484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXV0"/>
    <dbReference type="FunCoup" id="F9WXV0">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXV0"/>
    <dbReference type="GeneID" id="13394369"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31400"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.611"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXV0"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP92508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="58" mass="6634" checksum="0EC3CB09FCA8DD1D" modified="2011-10-19" version="1">MVKPITGMLRRGLVLDLSVAFGLGTAFGYGWWYGFHVPSVRRRDLFYAKLEDQRAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY49</accession>
    <name>F9WY49_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_107324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856390.1">
        <property type="nucleotide sequence ID" value="XM_003856342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY49"/>
    <dbReference type="STRING" id="336722.F9WY49"/>
    <dbReference type="GeneID" id="13394947"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107324"/>
    <dbReference type="eggNOG" id="ENOG502S9F6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634929_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY49"/>
    <dbReference type="OMA" id="PGMVYAY"/>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="432" mass="48180" checksum="76BBF6126047BF35" modified="2011-10-19" version="1">MSGAGANYDYPPHHHHQPVSAEQQPPPQMALPSIQHFDAQSQQQQQQQPPPPAPQQHYAPPPYNPATMLSHAQHPQHPPPYPPVQYQYHTGAVPPPAAPMQSASGQNGMMRYPIPPQASLESRQMSGGHSKKEIKRRTKTGCITCRKRRIKCDEAQPTCRNCQKSKRECMGYDPVFKQTPQPAPIQPAPNPPLLQQQHSTAHHHHLHQQSPLPPPPHHLNQQPPPPPPSQHQLHQSPSIPHNPYQSAPSYPGTGGAFGPAPIASYPTGAQSHQDYQPPSLDPALSTASPQQQNMAHNNYPPSLQPQRDVKSVSMEDLFSLHDVPPRYREGDTSVIQAVGLEVIDTSFKYHYASGLDRLFETTWYSQRGFAQLREDAELQSYFIQCMEQMSSRDESAVKATMSMEARLVWLLASLPRTAAYHLFPSETTSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYC0</accession>
    <name>F9WYC0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_32585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856542.1">
        <property type="nucleotide sequence ID" value="XM_003856494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYC0"/>
    <dbReference type="FunCoup" id="F9WYC0">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYC0"/>
    <dbReference type="GeneID" id="13395251"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32585"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1473"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9WYC0"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="436" mass="47000" checksum="F3E9948F87A32240" modified="2011-10-19" version="1">MSSSSQAPESWISAFCSLVGHEYFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEDASDEEEEEEEDDDEDEDEMHDGIDGLGRGSYRRAADAAAAAAERRHLRMASDLSMIESSAEMLYGLIHQRFITSRPGIQQMAEKYELGHFGHCPRVHCHGAKVLPVGCSDIPGQETVKLFCPSCLDVYSPPNSRFQTVDGAFFGTTFGCLFFMTFPELDVGGQKPPSSLDASASPLPGSSDKNGRSSLSSSLTSQQPGVPPPPLEAQPLPKQPDSINGVTPKNLAPGLGLGSIYEPRIYGFRVSEIAKTGPRMKWLRSRPRDVNELDECRLWAHNQEVLQQFAAANAAGADVADSEMADEVEEGEGEVDDQDMDAESGQVRSNGNGNIKEVTQRKKPGGASTRRKGTGHPDITAGAGLANGDGARAVRVGDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYU9</accession>
    <name>F9WYU9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856024.1">
        <property type="nucleotide sequence ID" value="XM_003855976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYU9"/>
    <dbReference type="STRING" id="336722.F9WYU9"/>
    <dbReference type="GeneID" id="13403963"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102134"/>
    <dbReference type="eggNOG" id="ENOG502SMZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870160_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYU9"/>
    <dbReference type="OrthoDB" id="5272500at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="31"/>
        </location>
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        </location>
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        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15280" checksum="3E470D7CF69A9E44" modified="2011-10-19" version="1" fragment="single">MASTFATSAPHQFEQHHSSMPSATLSSTMPDASPFQLREEDLETLSQSDGFTILRQHLAQHYTYDLCEIHSPCHVGNIEKWLIVRDVLHALLVPIVELFDKACGVAAIATGANRLEDLEYAFTGPSRGAFVWLQCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZE2</accession>
    <name>F9WZE2_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">MYCGRDRAFT_66501</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="336722.F9WZE2"/>
    <dbReference type="GeneID" id="13394977"/>
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    <dbReference type="eggNOG" id="ENOG502QTKQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007124_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZE2"/>
    <dbReference type="OMA" id="TNVGFEC"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
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        </location>
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            <end position="122"/>
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            <begin position="635"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="899" mass="97578" checksum="6A37B02729C975CA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZI2</accession>
    <name>F9WZI2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857776.1">
        <property type="nucleotide sequence ID" value="XM_003857728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZI2"/>
    <dbReference type="GeneID" id="13403347"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88648"/>
    <dbReference type="HOGENOM" id="CLU_1519055_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZI2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="177" mass="20326" checksum="FF9309134B64EED3" modified="2011-10-19" version="1">MSFKGHDTQPVTHSAFVPGLASVPWKSETLNAGLRHRLNGDSLHRTLLTVEHVQRAQNVRILTSWHTVKLEAAYSSRSSSQCIQLSRIEASCADFFVQFTGCYESWTKNMEEQSYRMRKSDIVTRHITESVGHRLLHAQQPRPAWRSKLKEVGSPTQRFYCGFVDQRSNMYESRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X044</accession>
    <name>F9X044_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_66157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857361.1">
        <property type="nucleotide sequence ID" value="XM_003857313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X044"/>
    <dbReference type="GeneID" id="13394788"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66157"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="F9X044"/>
    <dbReference type="OMA" id="VSETHAW"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36815" checksum="F28CAAEFF43F6EED" modified="2011-10-19" version="1">MSQILSFLPKFIYGQLFITPPAPTKDCAGKTVIVTGSNTGLGLEAARHFVQLNAAKVILACRNLEKGEAAEKDIESTTGRKGVVEVWQLDLTSYESVKAFAKKSQSLERLDILLENAGIAPPNFKLEEGSESTITVNVISTFLLALLMVPKLQETAKKHNTVPNLCIVSSEAHFFTAFPERNSSSIFDKLNDRSSARMTDRYNLSKLLEVFACREIAQDHPVSQFGVTITSVNPGLCHSELIRPEAPAVVRAFMTVMKAVLARTTEVGARTLVDASLRGQEDHGAFLSDCKVTEVAKLVTDEPETQTRVWRELAAKLEQIEPGVTKNLERGVSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0E8</accession>
    <name>F9X0E8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_32466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857127.1">
        <property type="nucleotide sequence ID" value="XM_003857079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0E8"/>
    <dbReference type="FunCoup" id="F9X0E8">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0E8"/>
    <dbReference type="GeneID" id="13395264"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32466"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1498"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0E8"/>
    <dbReference type="OMA" id="RDWYWWR"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="600" mass="69264" checksum="0ECD5DE935103420" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X147</accession>
    <name>F9X147_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857321.1">
        <property type="nucleotide sequence ID" value="XM_003857273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X147"/>
    <dbReference type="GeneID" id="13394907"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102508"/>
    <dbReference type="eggNOG" id="ENOG502SPM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139299_2_0_1"/>
    <dbReference type="InParanoid" id="F9X147"/>
    <dbReference type="OMA" id="EQTRWSC"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="116" mass="14006" checksum="5769A7D8DD58448F" modified="2011-10-19" version="1">MCYYDNFKFACQDWKWGNFRQHCQKEYRTGETCGMKMIYNTMLLAEKCPSCEKIEKKLRRRDKAMSDWKRWSQQGGKFKASMEKAVEDVKTLEREIEALQREKERRYAAVGNARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1U6</accession>
    <name>F9X1U6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_36580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855357.1">
        <property type="nucleotide sequence ID" value="XM_003855309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1U6"/>
    <dbReference type="FunCoup" id="F9X1U6">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1U6"/>
    <dbReference type="GeneID" id="13400753"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36580"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1U6"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="12992" checksum="08622A0DEEE79BC7" modified="2011-10-19" version="1">MTSTIGIPIKLLNEATGHQVTVEITSGQTYRGKLIEAEDNMNVQLENINVTQRDGRVTHLDRVYIRGSHVRLFIVPDMLRNAPMFRSKGVRGRGVGLARGRATVNRARGSGGPRGARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X252</accession>
    <name>F9X252_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854818.1">
        <property type="nucleotide sequence ID" value="XM_003854770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X252"/>
    <dbReference type="STRING" id="336722.F9X252"/>
    <dbReference type="GeneID" id="13403643"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107920"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.278"/>
    <dbReference type="eggNOG" id="ENOG502S4CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289380_0_0_1"/>
    <dbReference type="InParanoid" id="F9X252"/>
    <dbReference type="OMA" id="TVQACVF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114831" checksum="D20B2AF1C78441E0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X280</accession>
    <name>F9X280_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855600.1">
        <property type="nucleotide sequence ID" value="XM_003855552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X280"/>
    <dbReference type="GeneID" id="13403540"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90681"/>
    <dbReference type="HOGENOM" id="CLU_319381_0_0_1"/>
    <dbReference type="InParanoid" id="F9X280"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="910" mass="101632" checksum="70E5DD6D5A9A3598" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2H6</accession>
    <name>F9X2H6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_37219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2H6"/>
    <dbReference type="STRING" id="336722.F9X2H6"/>
    <dbReference type="GeneID" id="13403404"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37219"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.760"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_5_1"/>
    <dbReference type="InParanoid" id="F9X2H6"/>
    <dbReference type="OMA" id="IFMANTV"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="554"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="689" mass="74790" checksum="0964C72B5A794AD5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2W6</accession>
    <name>F9X2W6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor eIF4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_108058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854931.1">
        <property type="nucleotide sequence ID" value="XM_003854883.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X2W6"/>
    <dbReference type="STRING" id="336722.F9X2W6"/>
    <dbReference type="GeneID" id="13403492"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108058"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.565"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_5_0_1"/>
    <dbReference type="InParanoid" id="F9X2W6"/>
    <dbReference type="OMA" id="LPLQYHW"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30307" checksum="2E1A2EE9500032A9" modified="2011-10-19" version="1">MSSLSPQKFSDSPTDDGSPTASSPARGAEMINFLQTRLQKNRAPPLVHSWDFWHDRQDRAPTPNTQATSPASYEVRLEPLANISDVKQFWAVFNNFDVTQLKLRDSVHLFHRGVKPVWEDPRNARGGSWTFRVPKNHASEFWKEVCMMAIGEKLQAAVDEPDRTIFRDDICGVSLGVRFNSMLVQIWNRDGGHEKGIERIVQTLMENISPEMQPKEGSYYYKKHSEHAGFGASNVPALAPPPLQADNRPLRQSQLGLEVQSIDAVMQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3E1</accession>
    <name>F9X3E1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_36551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854757.1">
        <property type="nucleotide sequence ID" value="XM_003854709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3E1"/>
    <dbReference type="GeneID" id="13403696"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36551"/>
    <dbReference type="HOGENOM" id="CLU_2151907_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3E1"/>
    <dbReference type="OMA" id="QGWWEFG"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="112" mass="11932" checksum="C09CD2A806035663" modified="2011-10-19" version="1" fragment="single">FDSVIMTNNVRVISASMGPPLIVTTAIDIRPELCSRTGNLHGGAAALIFDMCTSMSVAPLATATSWPFGGVSRHLTVSYIRPVPVGIIVHIVCEVASLGKNICETLLLHERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3F0</accession>
    <name>F9X3F0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_37094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854764.1">
        <property type="nucleotide sequence ID" value="XM_003854716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3F0"/>
    <dbReference type="FunCoup" id="F9X3F0">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3F0"/>
    <dbReference type="GeneID" id="13403694"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37094"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698261_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3F0"/>
    <dbReference type="OMA" id="NYPGDWL"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395309" evidence="2">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="430" mass="45490" checksum="FB180C625BED3CB5" modified="2011-10-19" version="1">MRFSIASLALAALATQTVVADGWFGKSAYNKWHETELERWLSDHNVPYPKAADRKALEDLVKGNWDNNVVKPYSNWDVNQLTSFLSSKGQEVKKGSENTKESLLSQVQSLWTETADSANDAYGNVHDWIFDSWTESQLKAFLDYHHIPNPSPRTRDSLLSTARSNYQSIATKVGETAAYPGDWLYQSWSDSDLKAWLDERGVPVPQPSARDKMIASIRRNAKIGSDSVRAQYSTAAASAQSAQASLSDALFDSWSDSQLKEWADKNGVKVPQGSKRNEIIALARKHSAKIAGGASASATSAYGAATTSAGNFYAQGTNAVYGQFRGIYDKIANQIGLASAEAKASLSSASSIASVTASSASSVASVSASSASSSLSVKGSKSSSVASKSATSAASVASSSTQSAKKEAAKSAESSASKASASAKSAKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3L9</accession>
    <name>F9X3L9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">vWA found in TerF C terminus domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855635.1">
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
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        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
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            <end position="405"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90611.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51173" checksum="FFCE36189B46371C" modified="2011-10-19" version="1">MGLASKLAAAQGGAAAVANFTGGPPGQQPGAQPQQSYQAYAPGGRPPQGGPPPPGQYGAPQGQQGYGAPPPQGQQYPSQQQGYGGPPQGGQMSGPHDVQGYQRELERAIQEKQLHRFYGPGTQGAQMLPQIAARAAQQVDRLCQAWRIQKEIANDIVRLALYDVIIYVDDSGSMSFEENGERIKDLQLILQRSVFAATLFDDDGIELRFMNEDLPPQQISGIRNEQQVEQLLASKRYKGLTPFGTELRKKVIDPILIQKLNSGQMRKPLLIISITDGQPAGENQNTLIETVQYACQAAQRSQYGPGAVSFQFAQVGNDQKATEFLAKLDNDPMVGKEVDCTSNYENESAEMARAVPPVDLTPDLWMIKLILGAIDPSYDTKDEKTHMAPGMPPQQQGGGGYGGPPQQGYGQQQYPPQGGQSYGQPPQYGGAPQYGAPPQGQYGQPPPQGQRPPQQGGYPGQQQPYGAPPPGPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q1</accession>
    <name>F9X3Q1_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="F9X3Q1"/>
    <dbReference type="PHI-base" id="PHI:6547"/>
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    </dbReference>
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        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="110" mass="11947" checksum="62A4D67AFC23C6D0" modified="2011-10-19" version="1" fragment="single">CSHVGDHLISYECCCTIDHNDAILDSPYTSAGSEEYATCEVPYRHAISHLTGTAIPRSKSCVHLLQHRLVCLGTYTWRIRLCGGLFGEVAGIALAGNLAHNEERGASDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X402</accession>
    <name>F9X402_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X402"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91163"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="CEASEDM"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391298" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40616" checksum="4DC13D37FD9B6D87" modified="2011-10-19" version="1">MWKFLLCSALFTALTSALIIPSNIMLQLHEDPNFHYEAIRAIGTARYNGADISEWSNLAERVLSTIDESKLETYSPITLRDIYFRASHDFFIADFFLHGNPADPRMAEMFQNHGFEIPLIIYRAAEASKSVPRPTLIIGGGFDRNMEETLHDFGFAALEREYNVILYEGPGMPRLLHQQKKGFIHDWEKVVSPIMDYIETNKNGSLSFVDSSKIGLIGMSLGGYLAARAAAFEPRLAAVICLDGVFAFMPALESAMPERLACPTRPLADDGTYSLQTKTVVEFFSRIPAWDLTGVAGNIQMPALIGLAEDDLFFKGQPEKVAEAIGFRATLVYFGPDQAAHLHVASGALRYQNQAIFEWFAGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X490</accession>
    <name>F9X490_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
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            <end position="157"/>
        </location>
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            <begin position="7"/>
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        </location>
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        <location>
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            <end position="99"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22182" checksum="2046EF93A28909AA" modified="2011-10-19" version="1">MSGPYDQGYGQQNYNNQSYGYDTNYPPQGQGYQQGYQQQGSYPQQQPQYGQAQYGQPQYSQPQGYGAPPAPDYTGGQSGGYNPGAPPQHGGFQHNQQQQGYGGVSQYGAQQHDPYAQQQQNTYGAPPAGSDPNNPYGYQKDPADPNHPQEGERGFMGAVAGGIGGHLLGKQAGHGILGTLAGAFLGSKGEDKFKQSHHNKHSNQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9X497</accession>
    <name>F9X497_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="76"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="608" mass="68419" checksum="C415195CE490802E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4Z7</accession>
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        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="276" mass="30560" checksum="CD92BEA0EE52FC9A" modified="2011-10-19" version="1">MKILTKEEESAHYKATLTGGLMGGAAGTGLGALGVYAASARYPAFRGLTLPFRAFLIASTGTFASIVAADSYSRRFEASKQPGRDYADDQQILQDQLDANRTTKQKTMAWLQDNRYSIVLGSWVASISLAMGIVGKNPYLTTQQKLVQARVYAQGFTLAAVIVSLAFEGGDRMKGSGRWETVKILDPNDPTHKNMIEKKIHHEKYAGEDQWMDMVEAEEKRIKEREAAVKEREAENEKKNGNGKGKGKETHHKKEKTEHLDKGNPEEAKDKKVNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X511</accession>
    <name>F9X511_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_108602</name>
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    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X511"/>
    <dbReference type="STRING" id="336722.F9X511"/>
    <dbReference type="GeneID" id="13404164"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108602"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286554_0_0_1"/>
    <dbReference type="InParanoid" id="F9X511"/>
    <dbReference type="OMA" id="DRVSFAC"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="357"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="510"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="616"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="728"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1078" mass="112222" checksum="245230BE02BDDB70" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6D6</accession>
    <name>F9X6D6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_70002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854364.1">
        <property type="nucleotide sequence ID" value="XM_003854316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6D6"/>
    <dbReference type="FunCoup" id="F9X6D6">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6D6"/>
    <dbReference type="GeneID" id="13395551"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70002"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6D6"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="190" mass="22153" checksum="265D8AE387AB2B2F" modified="2011-10-19" version="1">MDAPEPETPFGAVSAQTTRFQRIYQSYLDKSTPYVTYRWIGTATIFVMFALRIVMAQGWYIVAYALGIYLLNLFLAFISPKFDPSLDADTDMEDGVPAGQSSLPTKNDQEFKPFVRRLPEFKFWHSATRAVTLSFLCSWSEIFNLPVFWPVLVVYWLILVFLTMRRQIQSMIKYRYVPWDFGKAKYDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6H8</accession>
    <name>F9X6H8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854069.1">
        <property type="nucleotide sequence ID" value="XM_003854021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6H8"/>
    <dbReference type="STRING" id="336722.F9X6H8"/>
    <dbReference type="GeneID" id="13404559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39267"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_33_1"/>
    <dbReference type="InParanoid" id="F9X6H8"/>
    <dbReference type="OMA" id="LEDPWVQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF191">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="385" mass="44171" checksum="7C8D63AEB1ABFC87" modified="2011-10-19" version="1" fragment="single">DRGAGSKARRLSVHLPETLEVDECQLEQHFNVMSRLSQKDIGEGGAAIVRLMKSKTAGTEKTKERLFAVKEFRARDTTEEEEYDYVRKIKSEYAISKSCQHPNIVSTFRLCISHERWFHVMEYCELGDLNDLIKKNYFSVEDRNCMFKQLIRGVDYLHSRGIAHRDIKSENLLVNKDGCLKIADFGTGEVFSGQHPGCRNCRRQSIIDPEEPIRLCAPGWVGSRPYIAPEVYQRKGDYDPRAVDVWSTAIVYLTLCFGGNPWDAASLECKNFNIYCDTWDQWLEKYPDGEIKKGRELPAFAGTKQFQSLDDASTKVLMFGMLHPDPTKRWTIAQALESKTVTEYACCQQEGYSDDIRKRQKKALHNHVPPKDPKGPKFLKPSFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6J0</accession>
    <name>F9X6J0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALD2</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_39109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854072.1">
        <property type="nucleotide sequence ID" value="XM_003854024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6J0"/>
    <dbReference type="STRING" id="336722.F9X6J0"/>
    <dbReference type="GeneID" id="13404551"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39109"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="F9X6J0"/>
    <dbReference type="OMA" id="IRWHAEL"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="53217" checksum="7D6ED82C5F194DAF" modified="2011-10-19" version="1">MSSLSLKLPNGQQYEQPLGLFINNEFVEGRGEKFDVLDPALDKKILTLAGASPDDVNDAVKAAREAFETGPWADFTGKDRSNILWKLARILKREEKLLAAIDAYDLGKPFEATLAGDLDETVNVFEYYAGWADKIDGKTIDTSPDKLAYTVQEPLGVCAQIIPWNFPIMMLAWKVAPALACGNVVVLKPAEQTPLSAMYFCTLIKEAGFPPGVVNIIPGLGNITGKALAEHMDVDKIAFTGSTATGKSIMRSAAANLKNITLECGGKSPLIVFEDAELKNAVQWAHGGIMDNSGQVCTSTSRIYVHEKVYDDFLKTFVEFTEMNSTVGAPFDEGATHGPQVSKAQYDKVLQYLEKGKSEGAKVLTGGAKVDRDGYFVQPTVFVDAKEGSQIIKEEIFGPVVTISKFSSDAEAIAMANDTEYGLAAALFTEKISRAHKVARKLKAGMVWINSSGDSHYGIPFGGAKSSGIGRELGSYALDAYTQTKAIHVNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6J8</accession>
    <name>F9X6J8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854207.1">
        <property type="nucleotide sequence ID" value="XM_003854159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6J8"/>
    <dbReference type="GeneID" id="13404415"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92103"/>
    <dbReference type="eggNOG" id="ENOG502R9DQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210629_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6J8"/>
    <dbReference type="OrthoDB" id="3649946at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="229" mass="25519" checksum="53E884DAACFBF489" modified="2011-10-19" version="1">MSGSSPWNVEPLSFAPNTNAMDEKSMPSDKAAAARVKSALVMDAVKRGDMKEADRLMGEQKETGTKGLVPMQWARDIFKGKKGKDQPEILQGKDMDGEESVYSVDAEKGKVGANCSQRSRDATAIIKHADFPSLHLPALHSTAHTQTNTTPPPDHNGLTNNPPIFISRELSITHLHPREPSWSHISQVKRAIAFYDANEPQKMRDLRPRHLKRPETRPTPDAYTQNIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6K9</accession>
    <name>F9X6K9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_56211</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853666.1">
        <property type="nucleotide sequence ID" value="XM_003853618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6K9"/>
    <dbReference type="FunCoup" id="F9X6K9">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6K9"/>
    <dbReference type="GeneID" id="13395801"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56211"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.127"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131611_2_0_1"/>
    <dbReference type="InParanoid" id="F9X6K9"/>
    <dbReference type="OMA" id="VNMKDEY"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="13280" checksum="D3E26833DA6B41E5" modified="2011-10-19" version="1">MGVFQTKKFRSSAQNNTVAAKYRSALARRPFALFGLPFIATMLLGSFFLTPATALRYERHDRKVRQVTKDEELGIGKDRRKIDLAEEYYKLSAKDLDSWEQKRVKRLPGEHDGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6S9</accession>
    <name>F9X6S9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_37787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854486.1">
        <property type="nucleotide sequence ID" value="XM_003854438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6S9"/>
    <dbReference type="GeneID" id="13404109"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37787"/>
    <dbReference type="eggNOG" id="ENOG502SG6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025630_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6S9"/>
    <dbReference type="OMA" id="MFYAFIN"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="100"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="40375" checksum="1884744B02DF1927" modified="2011-10-19" version="1">MRRAKIESSKEKPIEQTRCSTIDFRKTWQYANSRLPPHVPPMKMYMATWQIVCMAAQGSLDVYRRPQKEEKEDYVKADWRQGTKAMVINSRPVDDRNLIVIAIRGSRWNIIDWAVNFRPAPSEPIGFLDDEGNACHAGFLQVARAMVAPIAARLRNMLEQNPSRASSSLLFTGHSAGGAVASLLYMHMMATTFESELNLLTGCFKRVHCVTFGTPPLTFLPLHNPPGKKYERNVFLSFANEGDPVVRADRQYLSTLTRIIAAPSPLSDASLKQRMKQGNTSAADLKPLKWEVPPATLSNAGRMVLLRERPGKKGTVEAVQVTDEQLREVIFGDPEMHHMDLYKRRIDELAIAAVTGAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X731</accession>
    <name>F9X731_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_57344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="21329" checksum="743BF9959F5909D1" modified="2011-10-19" version="1">MKVFCASETDTGNPMFAALSNDNRFNRQRAWLQCNDFVNGHIVGAPRNENTLVGRLTTAEFFIKQCELWFPRGPNRETFGASKGRTADTLNAYTSGQNPTKARHIIYSSGSRDVWREMGVAATRRPGGPMRSDPEKDIVVHVLESGCHHSERSTRIAELYQDIRRVHDLEVDQVCRWAQQWPGYSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X871</accession>
    <name>F9X871_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_92291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853574.1">
        <property type="nucleotide sequence ID" value="XM_003853526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X871"/>
    <dbReference type="STRING" id="336722.F9X871"/>
    <dbReference type="GeneID" id="13397156"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92291"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.92"/>
    <dbReference type="eggNOG" id="ENOG502QPY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011075_0_0_1"/>
    <dbReference type="InParanoid" id="F9X871"/>
    <dbReference type="OMA" id="TAQAYRW"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF47">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="871" mass="96323" checksum="49AA0881E2983208" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X886</accession>
    <name>F9X886_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_24183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853518.1">
        <property type="nucleotide sequence ID" value="XM_003853470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X886"/>
    <dbReference type="FunCoup" id="F9X886">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X886"/>
    <dbReference type="GeneID" id="13397222"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24183"/>
    <dbReference type="eggNOG" id="KOG3789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014995_3_1_1"/>
    <dbReference type="InParanoid" id="F9X886"/>
    <dbReference type="OMA" id="IVMHKPD"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43747" checksum="7D1B0083BB473CF1" modified="2011-10-19" version="1" fragment="single">VPQSMLEAIFYARFHPERGPSVIHQYPAGSIISPPGSPCRPLINWADISSYIIPPYDLCNQSLSICTAGHRVLAFPISLEDAEYDRNRFTFNICFVLPEEEDAHPWESIVRKTARFLMAIETEDCVLQIEEDLKGLKLAGEAGYPADVGSIYTLLERILEDLNAYGETCIQVNSSQTLNLRLEFQRSAPPKVNTWDVPLLIRSLPSREEWTWDLTLQRIHMYIDGIRHVQKIAELADVEVKLVKRAVKELVLHGRAMVLDIFHFQAIYTCTRDLSAFVQDLDLQDECRRYVTIPQEPEVVETNDRHSISDVSIPGPTRESLVELYSSLHRGIQLADFCLTHQDELAHIDIRRFITFGVIKGFVQRLHKYALALEPLPGSTPAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8G4</accession>
    <name>F9X8G4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_85733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853394.1">
        <property type="nucleotide sequence ID" value="XM_003853346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8G4"/>
    <dbReference type="STRING" id="336722.F9X8G4"/>
    <dbReference type="GeneID" id="13397338"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85733"/>
    <dbReference type="eggNOG" id="ENOG502S4P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8G4"/>
    <dbReference type="OMA" id="SPSWMQW"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="22654" checksum="89DD4AFB9798D85E" modified="2011-10-19" version="1">MPPPSPASPSLVTRVWHTWKSLNLPWRKQFLKGSDLSGNTFWEFRDALNANRMRRIVKHAKGRHVSYSDVKISPQWHQWLRHTRDEPPTLPEQHAEIARQGRMRQLAAEADERWKSIPSFLDNPRTAAAPQLETEPISPTGGKPEEEVTGEKKKDAYSFKPKKARKENPFDKALPKGNAGENWQPEGWTPGVAPRRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8S7</accession>
    <name>F9X8S7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_40422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853555.1">
        <property type="nucleotide sequence ID" value="XM_003853507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8S7"/>
    <dbReference type="GeneID" id="13397180"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40422"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.137"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="F9X8S7"/>
    <dbReference type="OMA" id="GMGTQAM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="554" mass="61238" checksum="406DE52D85CFAA9F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8T9</accession>
    <name>F9X8T9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_70762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853548.1">
        <property type="nucleotide sequence ID" value="XM_003853500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8T9"/>
    <dbReference type="STRING" id="336722.F9X8T9"/>
    <dbReference type="GeneID" id="13400669"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70762"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="InParanoid" id="F9X8T9"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="255"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="449" mass="51342" checksum="548B2D71CD771D23" modified="2011-10-19" version="1">MSVLLETSAGDITIDLFVQDAPTCCENFLKLCKIKYYNYSPIYNVQPSFSFQTGDPIGPESKDSDGGSSIWGLPDGVTKRTSRPEKRTFKPEFSSKRKHTDRGRVSMATTASKVNPDERLASSQFIITLGDNLDQLDGKAAIFGEVVEGFDALEKINSAFVDQNGRPLQDIRILHTVVLDDPYDDPAGLVEPPSSPPPSAEQRATVRIAHDEVLQENTDPEQLEKLRREREARAQALTLELIGDLPFADVTPPEQILFVCKLNPVTRDEDLELIFSRFGKILSCEVIRDKKTGDSLQYAFIEFANKEDCERAYFKMQGVLIDDHRIHVDFSQSVSKLSADWRNNTNSKTARSRGGFGGIDSLQQRKQYRSDDRGKDGRSRHYDYVFDKRAKPDDPDEDGGGRERKRSRSPRRERYDDDRRDDRRGGRDERRRDDRHRERSRDRHRSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9A5</accession>
    <name>F9X9A5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_92903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853171.1">
        <property type="nucleotide sequence ID" value="XM_003853123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9A5"/>
    <dbReference type="GeneID" id="13399720"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92903"/>
    <dbReference type="eggNOG" id="ENOG502SSRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434910_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9A5"/>
    <dbReference type="OrthoDB" id="3641574at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="629" mass="69232" checksum="B9EB7AC82A6E83BD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9M0</accession>
    <name>F9X9M0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_71081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853433.1">
        <property type="nucleotide sequence ID" value="XM_003853385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9M0"/>
    <dbReference type="STRING" id="336722.F9X9M0"/>
    <dbReference type="GeneID" id="13397297"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71081"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.394"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="InParanoid" id="F9X9M0"/>
    <dbReference type="OMA" id="IHSKTRM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="425" mass="46785" checksum="E758C0A01D0FB44F" modified="2011-10-19" version="1">MAPASEAGLNVLILGGGISGLTTALALTKFAPEGSVPRIRIFEIRPELATIGGAVNLTPNALRMLDHLGALPIIRKNNYGRDIDFLEVFDAHSGKLAETSFRGPDGDGIGNPPYKALRITRGEALKGVIAAVEQHENISITCGTRTVKIDETADEVTIHFENGESATGDLLMGCDGIHSVTRLKHVEPERKATYSGVSNAFGFSPIAKDFEVHFECTAINFARRGMLLTSFHSPEADSVYVGALMQVEDIGSRDGWKSVGADAEKTRAQLLERFGDAKIPCIRPLIENAKDFFLWPVFTLTNGGKWSTDRVMLLGDAAHAMPPQGESTGIVFEDTVLFSRCLTRWIEKGKPNTMKEAFNAYENLRRKRIDTAFEESKNVVKTVSDAGWLGHTIKTFVVPWYLWFTKNYREAHFIEDVTTTDIGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9M7</accession>
    <name>F9X9M7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_85776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853352.1">
        <property type="nucleotide sequence ID" value="XM_003853304.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X9M7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9M7"/>
    <dbReference type="GeneID" id="13399277"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85776"/>
    <dbReference type="eggNOG" id="KOG2148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002075_1_0_1"/>
    <dbReference type="InParanoid" id="F9X9M7"/>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1356" mass="150930" checksum="F0521E65F52871A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9N6</accession>
    <name>F9X9N6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853346.1">
        <property type="nucleotide sequence ID" value="XM_003853298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9N6"/>
    <dbReference type="GeneID" id="13399280"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92686"/>
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    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="617" mass="70003" checksum="F52E4ED21E344E7F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Z3</accession>
    <name>F9X9Z3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_85807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="protein sequence ID" value="EGP88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853326.1">
        <property type="nucleotide sequence ID" value="XM_003853278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Z3"/>
    <dbReference type="GeneID" id="13399301"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85807"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="InParanoid" id="F9X9Z3"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="512" mass="55957" checksum="4EAF188BC4C90396" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Z9</accession>
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        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_40778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0000702">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="205"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="484" mass="52723" checksum="5969316967DB171C" modified="2011-10-19" version="1">MARTTRAAAAKANENLKSKSSHLSSPPATPVVKGKKSAKATPAIKKETPATPTQLSTPASNRKRTRKTIKQEDQGDVNELPHNLAVLPTPESDEVDEAPAKKRAKRSAEADDDSEIAAKIEDVAESPEKKQTPKKKTTKYKLNPGISPYPNYPRPTPEECHEVVRILEKLHGKVNVPKVVPPPSLEVAGCGEVPSVLDALIRTRLSANTTNKNSSTAFQGLVKRFGTLKEGVGKGSVDWDAVRTASNHDVFKAIERGGLAKIKSKDIQSILQIAYEENQERKAALTGSAEDPAGAEHAQESEKQDEIEKAEQNVISLDHLHLLSRDDAIRKMVEFPGIGLKTASCVALFCMGHASFAVDTHVFRLCQYLGWVPKSTKKGEPKVDRDTTFSHCDVRIPDELKYALHQLLIKHGKTCPRCRAATGQSSANWEEGCPIEHLVKRHGAKKGGVSVKDRKKAEVAATGEEEVAKDESELSDVASEFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA69</accession>
    <name>F9XA69_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_104155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852989.1">
        <property type="nucleotide sequence ID" value="XM_003852941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA69"/>
    <dbReference type="FunCoup" id="F9XA69">
        <property type="interactions" value="1046"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA69"/>
    <dbReference type="GeneID" id="13397310"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104155"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.420"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA69"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="241" mass="27738" checksum="5DF7E684BD7C444A" modified="2011-10-19" version="1">MKLNISFPANGTQKLIDIEDEKKLRVFMDRRMGHEVPGDSVGDEFKGYVFRITGGNDKQGFPMKQGVMHPTRVRLLLADGHSCYRPRRTGERKRKSVRGCIVAMDLSVLALAIVKQGDADIPGLTDTVHPKRLGPKRASKIRRFFGLSKEDDVRKFVIRREVQPKEGKEGAKPYTKAPRIQRLVTPQRLQHKRHRIALKRRQAEKVKEAANEYAQVLHKRVNEEKSKQAELRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA93</accession>
    <name>F9XA93_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853001.1">
        <property type="nucleotide sequence ID" value="XM_003852953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA93"/>
    <dbReference type="STRING" id="336722.F9XA93"/>
    <dbReference type="GeneID" id="13397322"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109128"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.444"/>
    <dbReference type="eggNOG" id="ENOG502SXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071115_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA93"/>
    <dbReference type="OMA" id="NDCPASN"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28646" checksum="FD60E909C5668C24" modified="2011-10-19" version="1">MMDPSPSLPQRMSALYQYHNAPEVAPAHGLEYDDNVYPSSDKYPVLRESPASAHDRYNRHAFDNDNRPPRIIFGMKIKTFLVVAAIMILIVVGAAVGGAVGGKQLRDQHEADMFNNATSPSRPSTASASSTYNAPVPTYEPLSDCPDSDNTLYTSSFAHISDTSTLTTSSNTSHASAGLSFTKHCALSNPITDKAKLTSAFVYSFSDCVEVCAAYNYWADSSECSVAVYQSNATRPANCWIGKIPELKASSLKPKDGIDVATLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAB4</accession>
    <name>F9XAB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_104277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853111.1">
        <property type="nucleotide sequence ID" value="XM_003853063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAB4"/>
    <dbReference type="STRING" id="336722.F9XAB4"/>
    <dbReference type="GeneID" id="13399324"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104277"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.698"/>
    <dbReference type="eggNOG" id="ENOG502QVPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036089_0_1_1"/>
    <dbReference type="InParanoid" id="F9XAB4"/>
    <dbReference type="OMA" id="APFIERK"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="42931" checksum="D16307663A601B01" modified="2011-10-19" version="1">MGLKGVHFGGGNIGRGFVAEFLHNSGYEVVFVDVMDSIIESLQKTSSYEVTEIGPDGESKFTIDNYRALNSKHEMEKVIHEIATADIVTCAVGPNILKFIAEPIAKGIDARTEKKPLAVVACENAIGATDTLRGFIEGKLSDDSKTNIASKAEFANSAIDRIVPIQDEGAGLNVKIEKFYEWCVEEKPFNGSPPPIKGVHFVDDLEPYIERKLFTVNTGHATAAYYGHQAGKQYIHEVLEDPKLHDIVQNVLKETAHLICTKHDHISREEQEEYVQNIVKRISNPVLKDNVERVGRAPLRKLSRKERFIGPAAHLAEQGDSVECILGSIEQALRFQNVEGDEESAELAKKLKDMDSKAATKDITGLEESHPLFEKVEAIVKKVQGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAE1</accession>
    <name>F9XAE1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_92812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853122.1">
        <property type="nucleotide sequence ID" value="XM_003853074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAE1"/>
    <dbReference type="FunCoup" id="F9XAE1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAE1"/>
    <dbReference type="GeneID" id="13399783"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92812"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.729"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAE1"/>
    <dbReference type="OMA" id="MLDMNVK"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="305" mass="33532" checksum="3D103E7E4BC611A3" modified="2011-10-19" version="1">MPICIECRYPVATLYTTYSKADDKALGKGVRLTQCPRCKRFADKYVEHDFVVLFIDLVLIKPQVYRHLLFNRLGREDDTLDPSIKRLGVLLLLFDVYLTWARIEKATPSSPTLPLSPPPPLPPFQSGSNSSLFTPPDLIDHSSSYLASQPILIQYIFFLILCTVETASFHLPIIWLLSFRFPRPLSSAIPHYPHSALISTALLVSSFTKLFPLMLLVWKYDLPSSASAVSWAVIINNVAALEILLDCGYVRAAALAAVGAVFRAGIGWGILRVVGIHGGAAAAGVVETGDLIVVWRTLVETLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAN0</accession>
    <name>F9XAN0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852051.1">
        <property type="nucleotide sequence ID" value="XM_003852003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAN0"/>
    <dbReference type="GeneID" id="13397089"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92983"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.67"/>
    <dbReference type="HOGENOM" id="CLU_1416195_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAN0"/>
    <dbReference type="OrthoDB" id="10502474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="21417" checksum="220B2B34B34F650C" modified="2011-10-19" version="1">MAASATTALAPRALDFLDLTELENATMIFVLEPVPVNGRNLGRVARNEVLNLIDEVDREVLRTTPATATPAELKYSMGTKKFEVLVKLKEAAEEAEKKIVELEGKCGDDGEKKKELRAAKEKVLECMTEVEKAVKKVGAMVVLRKSERVMAESVGDPDILWREQSEFREMGMDGILAWVDFEVSEMARRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBD2</accession>
    <name>F9XBD2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_100283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852548.1">
        <property type="nucleotide sequence ID" value="XM_003852500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBD2"/>
    <dbReference type="FunCoup" id="F9XBD2">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="GeneID" id="13394037"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100283"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="InParanoid" id="F9XBD2"/>
    <dbReference type="OMA" id="YIWASAF"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51594" checksum="9A12253DE261BC1F" modified="2011-10-19" version="1">MGIDETEVISSGNVSDLEIDPARERRLVRKLDLWLSPMMIMLFLMSYLDRSNIGNAAIAGLNEDLDLDGNKLNVAVTIPCSLILKKARPSRFIPFFVISWSLVVIGSAFMQNYATLLATRLLLGAFESGLFPCLTLYLSTFYKPSEQAQRISYLFVASALSGAFGGLLAYGLTGLSGALAGWRWLFLVEGLISIAVGTACLALLPDSPETARWLNEDDKKLMRIRHQQVSIYQGESEVFDRQEVKLAFTDPKVWLSAACQFCANTCSFGFSTFLPTIIRGFGFSSVRTQLLTVPVYLWASFFYLSIAYFSDLVRRRAFFMVPLALVTAVGYCMMLGVEMSNTAVLYFATYATATGIYCCVGLNVTWISNSNAGYYKRATAIGLQQTIGNSAGIMAGQIYRLKNGDGRYVVGHAVSVAAIVLASVGYAIMFGVLDRVNKRRERMTEAERAALLDGGVKGDRHPDFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBK4</accession>
    <name>F9XBK4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division control protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDC1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_72693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852408.1">
        <property type="nucleotide sequence ID" value="XM_003852360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBK4"/>
    <dbReference type="FunCoup" id="F9XBK4">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBK4"/>
    <dbReference type="GeneID" id="13394184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72693"/>
    <dbReference type="InParanoid" id="F9XBK4"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="497" mass="56610" checksum="66E9B359B1FF8269" modified="2011-10-19" version="1" fragment="single">MNAQNFYVQFCRRTARRYPFLRRFSVTTIGLILVWTIAIYTGERSTFASHITSCAWESWEEWPQDAAPHRLVFVSDPQLVDPHTYPGRPWPLSSLTEFFTDKYMARNFRLINRELDPDSIVFLGDLFDGGREWRTSQFISGEQGRWKEYGTSQWTLEYNRFGKIFFAPEQLYPRADRAITAARDRKIKTNLPGNHDLGFGTRVQIPVRDRFEAHYGDTNTVYVIANHTFISLDTPSLSAADEMTDPEHKQQARLEHVWQPANDFLNKLDAAGPKVVAEALNEYFPTARPSQGFSHEVFDPKEASRRPTADKHTAEPRLPLVLLTHVPLFRPDGDHCGSQRERGRAIPISHGYQYQNVLTPGLSSTIARKISETGDLVHVFSGDDHDYCDLVHRFNVKPWIDGKIQDKPVMKAIREITVKSFSWAMGVRRPGFQLVSMWNPVDAQGISIGGTPTTIQTHLCLLPDQLSIFINYGLLLGVTLVVLIVRGVVLSLRKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBU6</accession>
    <name>F9XBU6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852505.1">
        <property type="nucleotide sequence ID" value="XM_003852457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBU6"/>
    <dbReference type="GeneID" id="13394083"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109626"/>
    <dbReference type="eggNOG" id="ENOG502RFYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544245_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBU6"/>
    <dbReference type="OrthoDB" id="3648876at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391273" evidence="2">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="501" mass="51780" checksum="778326EB4231EE16" modified="2011-10-19" version="1">MLSLSFLLTALLCFANANPLPGSRLQARQTQQVSITLSVSDSQFRSFENSATLKSYLQSQGYNYNLNYNQLSQTIVSTENYFASKAASTTSTNSLAPPNSDAIQTDSDSTTLNGDASYTNISATADTNLVSAFSFSDGNAASSGGAIQRRKTISSTSSSGTADSTATVTGSTNPVSIFSSADVPSASTSTTLQGSPQDALAAGTCAAAANGASASAQVVTTVTYPVGSSGRSATSGSVSSIFCESGVSARSSGAASGSGTSTGLARAALTDGGVSAQAPINIRLDANHSDLRPPAPPCYAPATMVSLVLPYATNGVWPFGNLTVRLARLAKQPSTPSSPSSPLWLQVGAALPHGDIDRRASVVPAICANSDCGRKRDESAAAAQLQDHLDRRSVPWPDTCADPPCDRKRDAPATAAVQVRNDLNRRASVYPQTCVDNDCKIKREDSAAAAQLQDQLESRASVVPENPDCRMIGDCEVKREAADGKEKPDASVYPPSCVMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC66</accession>
    <name>F9XC66_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852473.1">
        <property type="nucleotide sequence ID" value="XM_003852425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC66"/>
    <dbReference type="GeneID" id="13396796"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93485"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.711"/>
    <dbReference type="HOGENOM" id="CLU_776607_0_0_1"/>
    <dbReference type="InParanoid" id="F9XC66"/>
    <dbReference type="OrthoDB" id="10365460at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="390" mass="43280" checksum="339AE81FF04B7554" modified="2011-10-19" version="1">MADQKPVIIDDDNNPALDVETRLELADLDHQLLESERKLLESKKRKIMLAHEHKLSRNKGPHRPAKPGVAETERSKETVVSTQDRADGRDGNKRIKVERGLMEARTPPQKDIVDLTKSASPADDIRVRDRVARPQRRRSKFYKGARLRPDVDYRESETESLDLNDDSDSDSEAEDSAPPNTPYNYRRINPAFPTICRMPDGSLAELHCSGCHSNAMFRDGEVRFLEVGRSLQTHYVACHRELTANKEGRRLTCGELMEMSVYKILSAAKAAAVRGDTQEDYHVEVALTPGAQMRYDQSRGQRPKKKSGGKANQALASAAPGGYAQEEDDDDEEQDPGPPTPPESIATRTSMADGDDDGRAPAAKPKQQFARKSAPGGGALAYAWPWRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC97</accession>
    <name>F9XC97_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_41539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852631.1">
        <property type="nucleotide sequence ID" value="XM_003852583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC97"/>
    <dbReference type="GeneID" id="13393970"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41539"/>
    <dbReference type="eggNOG" id="ENOG502RXM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="InParanoid" id="F9XC97"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="122"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="273" mass="29721" checksum="AAB01741C83B07F5" modified="2011-10-19" version="1">MSGIGAELPPHLLAKRKRQQDEDADVAPTTASGAKRASSPDEPDKRQRVIGPAMPPAPLDQRPSHPPNTIEDDSSDEDDDFGPALPTGDAISNDNDDHTQNAVSDAPQAEEKLKRDDWMMMPPKQDDLAARMDPSVQRPRGFNTGKGAKAPNTGGDDSSIWHETPEQKRKRLADEMMGVGTTSTTTRPNPAKISKKTGAHEKIQEHMEKTRGPSLMDQHAKTKGVEAEDDPSKRAFDREKDMGSGGRISTTQKREMLNKAAGFSDKFSGGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCD2</accession>
    <name>F9XCD2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_42681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852347.1">
        <property type="nucleotide sequence ID" value="XM_003852299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCD2"/>
    <dbReference type="GeneID" id="13394124"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42681"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="F9XCD2"/>
    <dbReference type="OMA" id="DPYQRWV"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29797" checksum="A1D974C70A5A9DA2" modified="2011-10-19" version="1">MSRHINVPWLALPSGSCCLKGHLHVGDPRGTFETIAGVDTYVVKPPEGKANGHVLFYFADVYGLFTNAQLVMDEFADEWIHAGYLTLGLDYFQNDPVFLHRDGPKTSKPGFDFEAWKEKHTAFADAKVPEWTAEAKKQYGQAATKYACVGYCFGAPYVCNSLADGTCQVGGFAHPAFLKEHHFRNLKAPLFLSCAEIDHTFATESRNRAIDRLREDGREYQLQLFSGVQHGFALRANLNVPYERWVKEQSLKGLTVYFDFWLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCI4</accession>
    <name>F9XCI4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_41683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852208.1">
        <property type="nucleotide sequence ID" value="XM_003852160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCI4"/>
    <dbReference type="FunCoup" id="F9XCI4">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCI4"/>
    <dbReference type="GeneID" id="13393984"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41683"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.409"/>
    <dbReference type="eggNOG" id="KOG3164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XCI4"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="301" mass="33324" checksum="4EC3A3C30F429D91" modified="2011-10-19" version="1">MRGKRSKQYRKLMQQYQLNFSFREPYQVLLDSGIITSGSAFKMSLGHMLSSTLHGEIKPMITQCSIRHLYNAPASPTKDQCIEVAKQAERRRCGHHELEQPLSEFECIMSVVDPKGSGTNRHRYVVASQLDEVRKALRKVVGTPLVYVKRSVMVLEPMAQATEEVREREEKSKIRAGLVGRRETGGGEKRKRGEDDEADGEERQEKVEAKKRKVKGPKGPNPLSAKKAKSGKAEEKEGEKAALRKVMKKDPQAAEKAGLLGGAAEDRETGGDATKKRKRKRKPKDAATGGVEAASEAGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ0</accession>
    <name>F9XCQ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_93696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851369.1">
        <property type="nucleotide sequence ID" value="XM_003851321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCQ0"/>
    <dbReference type="GeneID" id="13401276"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93696"/>
    <dbReference type="HOGENOM" id="CLU_909752_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCQ0"/>
    <dbReference type="OrthoDB" id="3649689at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="35529" checksum="861075CBB3404D8C" modified="2011-10-19" version="1">MERPTKPVDYKSLSDEELRKLCVQHGLYSNKRRMLAAQTYINALKARDRKLFGIRPPKHNYALDYKCYAPADLRSFCATFRFFDLPPELRVVVYSMLLNHQRGDKVGRTKTLASIAYPQILRASKLCYREARGVLYQQSSLTMKVSTWDERLRVRGDIAFGVEKGKETVDLFGRLLPKFAGIWHANVVLVEDDYGDFDDWSLEWTLQALVKAFRRKNALKTLTIKFVCTCGSRRRHERRKKGEAKTTPQEIEELETELRTSLRRLPATTQVQLTGLEKISSQTMRFMLARADYVQETRLKSTPVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV3</accession>
    <name>F9XCV3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HHK1p</name>
        <name evidence="19" type="ORF">MYCGRDRAFT_72887</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851927.1">
        <property type="nucleotide sequence ID" value="XM_003851879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13401383"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72887"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.171"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001037_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCV3"/>
    <dbReference type="OMA" id="QLPGYTW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="58"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="1884"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="2158"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2106"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2305"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1840"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2324"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2365"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2390"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2416"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2434" mass="269308" checksum="AA3D42B6A236BE20" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDJ1</accession>
    <name>F9XDJ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_93945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851527.1">
        <property type="nucleotide sequence ID" value="XM_003851479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDJ1"/>
    <dbReference type="FunCoup" id="F9XDJ1">
        <property type="interactions" value="937"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDJ1"/>
    <dbReference type="GeneID" id="13402180"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93945"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.412"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDJ1"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP86503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="287" mass="32102" checksum="E67D1B43013FACF9" modified="2011-10-19" version="1">MLYIIGLGLADERDISTKGLEIVRKADRVYLEAYTAVLLVEKEQLESYYGRSIIIADREMVESSSDEILANADAVDVAFLVVGDPFSATTHTDFVLRCRQHEPPIPTRTLPNASILTAVGATGLSLYNFGQTVSMVFFTDDWRPDSFYNRIRENADLGFHTLVLLDIKVKEPDLKAMARGKIIYEPPRFMTVAQCASQMIEVEEARAGNVCNKEKLAIGVARLGSEGEQIVAGTLEELTQADLGKPLHSLVLCGKTMHEMEWEFARGYAVDQAKFDEIWKRDYGIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDU5</accession>
    <name>F9XDU5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_73369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851763.1">
        <property type="nucleotide sequence ID" value="XM_003851715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDU5"/>
    <dbReference type="GeneID" id="13402051"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73369"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.527"/>
    <dbReference type="eggNOG" id="ENOG502S179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="InParanoid" id="F9XDU5"/>
    <dbReference type="OMA" id="IPIWHIF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30207" checksum="438FB93B137765AC" modified="2011-10-19" version="1">MTDHKDINGVDQLSRIQTAQSVNISMEMFEKLYLNPENRVRGHLRSTFANPTPLPLLGFLIASTPLACALMGWRGAGGGGAATVGTYYFFGGMLQIIGALLEWVIGNTFIYIVFGSFGAFWLAFGATLTPYFNAEGAFTSGATTTAEMEAGVQSFQASLGFFLLFMGVLVFMYLICSLRTNAVFFMIFLCLDMSLFLLTAAYWKGAEGDTAAFERLEVAAGAFVFAFCMFGWYLFFAQLLRAVDFPLDLPVGDLSGLIKARKAKPDIEKNVEPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE19</accession>
    <name>F9XE19_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_100383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852010.1">
        <property type="nucleotide sequence ID" value="XM_003851962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE19"/>
    <dbReference type="GeneID" id="13401243"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100383"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.4"/>
    <dbReference type="eggNOG" id="ENOG502QZDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="InParanoid" id="F9XE19"/>
    <dbReference type="OMA" id="FWTKHGY"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="318"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="594" mass="66600" checksum="8FB0338141C146C6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE52</accession>
    <name>F9XE52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851992.1">
        <property type="nucleotide sequence ID" value="XM_003851944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE52"/>
    <dbReference type="GeneID" id="13401228"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43638"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.35"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046808_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE52"/>
    <dbReference type="OMA" id="TDCLAAH"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781:SF1">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="329" mass="34567" checksum="7A0B06D6CAA362C2" modified="2011-10-19" version="1">MGKLMIYGATGYTGTLITQHAKATGMHAVLAGRSGEKLLSLAATLDFPYQHFDLTDPSTIDANLADISVLLNCAGPFAATAEPLIKACIRNGVHYLDTSAEPDTYTLAAQSDLEAQASKTMILPGCGGSVALFGCLVSRALENIPPTDVQSVDLALHVSGSMSRGSAITAAAGSASPTLQRHGGKLVTHEPSATTQLDFNDGRGPVPCFPVTLPDLITIHKFFNIENIRTFANVSGTAFPDGDLYDLPDGPAAEERERSPYHAVVVVTLKDGTVERTSVRTVNGYDLVARASVEAVRRVMGGEVLMGFQTSATVFGEGFVLGGASRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEN8</accession>
    <name>F9XEN8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850597.1">
        <property type="nucleotide sequence ID" value="XM_003850549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEN8"/>
    <dbReference type="STRING" id="336722.F9XEN8"/>
    <dbReference type="GeneID" id="13401112"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94265"/>
    <dbReference type="eggNOG" id="ENOG502SGFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059611_1_0_1"/>
    <dbReference type="InParanoid" id="F9XEN8"/>
    <dbReference type="OMA" id="PYKGVAN"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="165"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="353" mass="39027" checksum="B2AF1CDCB2148349" modified="2011-10-19" version="1">MAWSRTPFEGPQTECLQKLAIKLATNGPHKTLPTPRLIQLQHAGVFIIKTTSAVLVWEHLYYPQLYLPLKALEDPALSSEPGSEIHDPNTKARIAQVLTLTVASRTIPNVLSFSANLSGSATSLSNLVRIPFDAIDTWYEESTPIYVNPKDPFKRVDVLLSTRPIKVRIGGQVVASTTTSMHLYETGLPARYYMPLSAIDGTVLRKSDTRTKCPYKGEAEYYSVEVGGEAWKDVVWFYRSPILECAKIEGGFLLSCRFGHSESADDAIGLCCFYNEKVEIELDGEVLETPVTHMSNANPNAKPPAARNKSITTTGANTIRRVTPTHQDNSTITILANMQFNRHLFLAALAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEZ4</accession>
    <name>F9XEZ4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851251.1">
        <property type="nucleotide sequence ID" value="XM_003851203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEZ4"/>
    <dbReference type="GeneID" id="13395346"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94313"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.144"/>
    <dbReference type="eggNOG" id="ENOG502S8WV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009741_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEZ4"/>
    <dbReference type="OMA" id="AKHESRN"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="112897" checksum="FC9A207DF799B69F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF42</accession>
    <name>F9XF42_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850882.1">
        <property type="nucleotide sequence ID" value="XM_003850834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF42"/>
    <dbReference type="GeneID" id="13397719"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94770"/>
    <dbReference type="HOGENOM" id="CLU_991126_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF42"/>
    <dbReference type="OrthoDB" id="10445131at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="281" mass="31243" checksum="223B296E3DF14B63" modified="2011-10-19" version="1">MPPIQDFLLVLHATVSDQEAEATFARTKAIFDVENICVLWLEETGGTTSSWAVRGGIALPEAAREHIRADPAVRLFFPRPARDRAAGGSVEPTTQPLRTRDFFLLVLSDNATDHANITTTERTKAMLEKERISVLEIKQGDSLNSFTVEVVGPLSDSVKTAIKTSPEVARFDLAASVSLPPLLPLRQMIQQPSLSFRYRMVLKQVTHKKWLRTSFQTEEALDQAAYILRGEGVTVLRVGCVSSMSGRRNVWEIETVVPIDERTLERIRGIDDVETLGIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF81</accession>
    <name>F9XF81_ZYMTI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    <sequence length="318" mass="35619" checksum="7FDA0C480F6F15D0" modified="2011-10-19" version="1">MPPEILSKIQAELFVDMHIIVQKKKYYFHDSDQLQTTVLNLAEWKEALGMRQVCHQMKLIFDDALSRAKREGSIRLVLDMKAHSQRPSKPVPNNPLYCGVPMRILNTFPQIDNVTAIFALPPPGAATQHLTHDVLLSLKGKIIRSTATEHSRTAIDFAIKSVSYALPHPDVAAGRRVPFLSPLTTKGLYELGRLFTKHVGELVESHYKVVHPGADVVLEVADHITTMRHLNASSSVEATGALLAKDNARSAAIDEAEKQRKAKAEANVKEEQAKAEAEKVKQDEWTRVHDCKKLGCKKAHDVNDLPPFSSRHNWLWND</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="81"/>
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            <end position="137"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15834" checksum="494F4181D1E516F9" modified="2011-10-19" version="1">MRGQMRERSEMQVLRCWTRVLQDVFSASRELCSGSLSWGMEVLRQGLRIAQGEAYDDKTGYEDEEAGCDGDQDQEADQTPHHCKETCTHEKVYDGGEAFDDEEIHDDEEIHDDEEVYDDKEARDGSRSRNSEDNNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFE4</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="EGP85891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="763" mass="85605" checksum="B5DD10A06F3335D2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFS6</accession>
    <name>F9XFS6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_73985</name>
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    <organism evidence="5 6">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851156.1">
        <property type="nucleotide sequence ID" value="XM_003851108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFS6"/>
    <dbReference type="STRING" id="336722.F9XFS6"/>
    <dbReference type="GeneID" id="13397441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73985"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.341"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="F9XFS6"/>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="552" mass="61243" checksum="21FB7106180CB9AA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFZ9</accession>
    <name>F9XFZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_74078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851113.1">
        <property type="nucleotide sequence ID" value="XM_003851065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFZ9"/>
    <dbReference type="ESTHER" id="zymti-f9xfz9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13397853"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74078"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.416"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_8_1_1"/>
    <dbReference type="InParanoid" id="F9XFZ9"/>
    <dbReference type="OMA" id="WTIKNIA"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007311666" description="Carboxylesterase type B domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="186"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="712" mass="75592" checksum="50BA8CE0ACE93687" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGM2</accession>
    <name>F9XGM2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_100838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850811.1">
        <property type="nucleotide sequence ID" value="XM_003850763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGM2"/>
    <dbReference type="GeneID" id="13397775"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100838"/>
    <dbReference type="HOGENOM" id="CLU_2123018_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGM2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="114" mass="12540" checksum="ACD2477C36E2AAB4" modified="2011-10-19" version="1">MSSDLPRSRAMLLHHLLRCSLARALILGLIPAVVIIMLIVMVFVSLLSILPFVFGIHVRITNDRPAAPLSFTLSDSILLLIDSLPAPKLRSICLGHDLPSRHLSQFPLHSASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGR1</accession>
    <name>F9XGR1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_94683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850831.1">
        <property type="nucleotide sequence ID" value="XM_003850783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGR1"/>
    <dbReference type="GeneID" id="13397569"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94683"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.613"/>
    <dbReference type="HOGENOM" id="CLU_531232_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGR1"/>
    <dbReference type="OrthoDB" id="10444273at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="56477" checksum="BEFA0D8882554DBF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH19</accession>
    <name>F9XH19_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850160.1">
        <property type="nucleotide sequence ID" value="XM_003850112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH19"/>
    <dbReference type="GeneID" id="13394436"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95403"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.664"/>
    <dbReference type="HOGENOM" id="CLU_1612123_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH19"/>
    <dbReference type="OMA" id="LPATYYE"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="17913" checksum="C674FF0A99643E33" modified="2011-10-19" version="1">MYNVDSLPPSYYEERLLADQAARLAKQQTQQKQHLADHTARLSAHLPHCTAQKSSMPCPQSLTFALSQQRPSMSRVPSSSGGGGGGVLGGIFQGFVKVRKEEGRWSGASTSGTCTPTAKETSPVTTPGVGGGMREDGRMTREEYDAWHRGRKRDCEVGAMPAFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH46</accession>
    <name>F9XH46_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_46450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850231.1">
        <property type="nucleotide sequence ID" value="XM_003850183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH46"/>
    <dbReference type="STRING" id="336722.F9XH46"/>
    <dbReference type="GeneID" id="13394527"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46450"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042002_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH46"/>
    <dbReference type="OMA" id="HAKIRND"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="244" mass="26381" checksum="EAA5061626BDCEB8" modified="2011-10-19" version="1" fragment="single">AWSNQSDLDPSQTCSDCWLGAQSIQLSSPLGYDEDAASSFANLTSSCNATGYDFSIPTPYSQNAPETVQAASADIATPAKCPDSYTIKPGDDCHSVARQLNVSSYSLLQQNYLDLYCRSFATAGTAICIPPQCDTYTWLPTDTCESVVSHHTSLSVPQFLAWNPNFNSLCGNSFNFIGYSVCISPPGGFRTYSYPTTPTPTNTTQPGYASTAAIVPPNARDNSTRNCGSWHTVHPTLRSHPHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHE6</accession>
    <name>F9XHE6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CYP-20</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_101114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850204.1">
        <property type="nucleotide sequence ID" value="XM_003850156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHE6"/>
    <dbReference type="GeneID" id="13394557"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101114"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.742"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="F9XHE6"/>
    <dbReference type="OMA" id="ELTWRVK"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="545" mass="61553" checksum="BBBB5D4E9B846CC8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XID3</accession>
    <name>F9XID3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_29926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850499.1">
        <property type="nucleotide sequence ID" value="XM_003850451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XID3"/>
    <dbReference type="FunCoup" id="F9XID3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XID3"/>
    <dbReference type="GeneID" id="13395152"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29926"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006633_4_0_1"/>
    <dbReference type="InParanoid" id="F9XID3"/>
    <dbReference type="OMA" id="YVIIELC"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
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            <end position="314"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="443" mass="50101" checksum="EB1A12D5D6FAC9B1" modified="2011-10-19" version="1" fragment="single">ESPLDNANFLSFEEWKKQNLAKMGQSPEDLQRAQQINANRQRPGDPSVTDSVPASAAGQQLAASPTLRSKDAGKTCKERTNYASFDCAATILKSNKECKSASSVLVENKDSYMLNICSADNKFFIVELCDDIQIDTVVLANYEFFSSSFRHFKVSVSDRYPVKLEKWRDLGTFEARNTREIQAFLVQNPLIWARYLRIEFLTHYGTEYYCPVSVLRVHGTTMWEDYRHQEELARGEEDELVLEAEVEAVPPVAQEPLASTVEDPKSTVHTTPPSVTKGPPTTQNNTSSMNTTRPAAAATSTTAPAPPQPSSQESFFKSFHKRLQQLESNSTLSLQYIEEQSRILRDAFTKVEKRQLSTTTKFLSTLNSTVMAELQNYRLAYDQLWQSTVIELEGQRESYQDDMLALSRRLTMVADELVWQKRMGIVQSTLLLLCLALVLFGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJU7</accession>
    <name>F9XJU7_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="266" mass="29335" checksum="E7673A6799F1AFC2" modified="2011-10-19" version="1">MAGNGGDSIFVTPGPEDLNLGSFNPRGMAGAARMGSDEADLSQRLEGQVNMQQARQAPFQAHISSHPQQPAAAEHTPHLTAGRPVQMQAAPAQAARRRQTHRQTRRGSAPSQQAPDQELIVIPDDGDPPLVTFRFNGAVATMPKTRVTRFVKAEGSKVFQSQAHHTLIDAHEAQFKDTALVISNPKTTKGYILQMYQSSWKSKLVRSCTAKRSYLHTVEGLKDQHAWDHERSSYQTTIVEPNVRILAQAERDLAKMDALIAFLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK31</accession>
    <name>F9XK31_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ERG8</name>
        <name evidence="18" type="ORF">MYCGRDRAFT_75847</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849609.1">
        <property type="nucleotide sequence ID" value="XM_003849561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK31"/>
    <dbReference type="FunCoup" id="F9XK31">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK31"/>
    <dbReference type="GeneID" id="13402406"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75847"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.521"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="InParanoid" id="F9XK31"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="464" mass="50162" checksum="466FA4953B744928" modified="2011-10-19" version="1">MVRDGAVAVSAPGKVLLAGGYLVLDRAHTGLVFGLDARIHVLVQDIPTSNGIVINQFTAHSPQFLEAVWDYGYRLTERNGGIEVTQLRIDADLNLNRNPFVETTLSYVLSYITSIVGPSICPATITILADNDYYSTPAAISNGKSNTDSRFYNFAIPLSKAPKTGLGSSAALVTAVTAALLRFYLPKTEFNLTTDISKRRLHNLAQAAHCAAQGKVGSGFDVASAVYGTCIYRRFSPDILVSRSEPGVPRFATELRDIVDENHHGGKWDTEIIKDAVKIPEGLRLVMCDVSCGSKTPGMVKQVLAWRKETPEEANAIWRDLDEANENLAKELKAVAESKSPNDYSGLTKCLTEIRELIRIMSEKSGVPIEPPAQTELLDACEKVPGVVGGVVPGAGGYDAISLLIEDREDVVTGLEKLFAGWDFKGDGSAAGGGGKVSMLGVRQDMEGVRLEEPQKYVDWLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKD3</accession>
    <name>F9XKD3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MT-A70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_75907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849528.1">
        <property type="nucleotide sequence ID" value="XM_003849480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKD3"/>
    <dbReference type="STRING" id="336722.F9XKD3"/>
    <dbReference type="GeneID" id="13402378"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75907"/>
    <dbReference type="eggNOG" id="KOG2356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027091_4_0_1"/>
    <dbReference type="InParanoid" id="F9XKD3"/>
    <dbReference type="OMA" id="EEWVWIK"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50799" checksum="77D47D7B32CAE407" modified="2011-10-19" version="1">MSSPILWENHDRSVVLIDIPRSIAAAQGSHDHPCSDSLLSTEPSTRPFVTNEPKTAAAKAKLVQNTTDAGIDLEYQGIIQAALRDVNDNYKGDWCLPRPFVVPSTVNGPGEKRKHCVGDDLTNSNAVVQAIEPELPHDLLASCDSISRSTASCQECPDDDPSFHSNCYSSTQSIEIQHVPEDGERNVHSFRIPLKATFSLSACSSSQSFMNGIRNQAQTHSTRRHFDIILLDPPWPNRSVKRARKSPGSSYATSSSLHDIYQLLAGMDLDMLMSEECLVGIWITNKSRIRDLVLGDDGVFAMWGLRLEEEWIWVKTTSGGEPVTPIDSVWRKPYETLLIGRKGREVGEAPKRRVIISVPDLHSRKPCLKLLLEPMAPRSDGCRVLEVFARHLVAGWWSWGNECIKFNWDGYWRAPVGNRRDESRTCRRRPSEAECASQLSQPADCERPADESQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKY6</accession>
    <name>F9XKY6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgSrv2</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_76018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848759.1">
        <property type="nucleotide sequence ID" value="XM_003848711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKY6"/>
    <dbReference type="FunCoup" id="F9XKY6">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKY6"/>
    <dbReference type="GeneID" id="13398773"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76018"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.53"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKY6"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="384"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="547" mass="58018" checksum="9E3DC5E6E2510ADD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKZ6</accession>
    <name>F9XKZ6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848765.1">
        <property type="nucleotide sequence ID" value="XM_003848717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKZ6"/>
    <dbReference type="GeneID" id="13398769"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110937"/>
    <dbReference type="eggNOG" id="ENOG502RYBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597456_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKZ6"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="458" mass="51551" checksum="FEDFABC46B2B4C90" modified="2011-10-19" version="1">MVVFWRRYAPPRLHLQASPTGIFGVRGGQWTLWNDLKVFYERHERPSPARSAYRDVESYQKDSWLCEETKTTKIENNSSVSQALPHRRHRLLTSADALLSLLRQCNLLNFDALDVKFLYSRRTDDRLVATLIVVDSVQDKIQAKVEPSEDGKDQAEAFLAFRRYVEVRLYELLQSVPEAGGGGKVQSAATGNGANVPIESPPSYDAAKDGTGGGAKTVPTSPANRPDSSLPLVGTFTTLTGIQESHIPSLWHHLRLQEDLTLMQYLPWPIPTSPSSLSTLLTHLITDRHFVLYAILADPSHVSLRPASPSPWPHPSCVGIIAYLDINTTHRTLEVGAVIFAPVLQRSIAATEAHYLLLRNAFSAELGYRRVAYKCATENVASRRAAERLGYVYEGRFRNHMIMRGVSRDSEWLSVVEEEWEGVRGALEEWLREGNFDEGGRQVRKLEEIRRERLGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLG5</accession>
    <name>F9XLG5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_20494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848912.1">
        <property type="nucleotide sequence ID" value="XM_003848864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLG5"/>
    <dbReference type="GeneID" id="13398489"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20494"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002741_2_0_1"/>
    <dbReference type="InParanoid" id="F9XLG5"/>
    <dbReference type="OMA" id="TIGHDQR"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="926" mass="100637" checksum="BE63DC40F58FE844" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM20</accession>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_50051</name>
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    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848433.1">
        <property type="nucleotide sequence ID" value="XM_003848385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM20"/>
    <dbReference type="GeneID" id="13396243"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50051"/>
    <dbReference type="eggNOG" id="ENOG502SNN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086091_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM20"/>
    <dbReference type="OMA" id="FHVMAKL"/>
    <dbReference type="OrthoDB" id="2421200at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="192" mass="19591" checksum="D17BA39FEA84181B" modified="2011-10-19" version="1" fragment="single">NPKGLAVAAAGPLFLALIPVTNWISQPGGFLEKGVNGVIGGVGLLASAGASTHIAQGGKIAALAAIYATATYALSGAASAGGQDAGTQGGRDNNHPRAALANLQGLPLRLYSAHQHLMEMFPGWAIAAALAQVISPNDQHIINLLGLHVIAKLFVHYPAYVLNNGGVRSGAHFFATSAILNVLLQLARKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XME0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96440"/>
    <dbReference type="HOGENOM" id="CLU_1385148_0_0_1"/>
    <dbReference type="InParanoid" id="F9XME0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391562" evidence="1">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="197" mass="21537" checksum="1E1045909C5C7864" modified="2011-10-19" version="1">MLAFKSTIILSLVTAALGVNVIRGTCVTHNTLYFEGGMKTDNLFGRCTVPYGQPPGVAENMCPWDNANCEFDVDAVTGLNSINAKCGIKDEMSESIFQAFFAGAQRYLLVMCLHAIQLRFSILIDAGGPRRPLRSRPRKNPLAAIHRGLISTTHLAKFETQPEAQELPMQRTNVEGARMVMLGNAASVELCSYQGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMV8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111231"/>
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    <dbReference type="InParanoid" id="F9XMV8"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="26509" checksum="A5807972454E4CD0" modified="2011-10-19" version="1">MARLRRGSNDSGDFVPTSTRRDNRSSKTDATTKTTRRQPTRSTGFAATTDERTETSKLIPRVAPTPEKKKRQVRLAPLNGVQASLGSLSISGASERESLAPKRRAPRPVLQKSRSITKEPAQADVESQVDFEESICCGELQESEDDSDVELPSLGDLLGWSGRDQVARKPTLPGKLEALSISREVPEPIKPSVVDVFDEDDQPPFKPFSRMKAQPATSSRPTCEINHTTTTHHSSTIDDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM5</accession>
    <name>F9XPM5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSP70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_77678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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    </feature>
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        <location>
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            <end position="511"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82803.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="60377" checksum="153F494C016BD3C5" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
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            <end position="159"/>
        </location>
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        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>F9XQ18_ZYMTI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ18"/>
    <dbReference type="GeneID" id="13401359"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97382"/>
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    <dbReference type="HOGENOM" id="CLU_689296_0_0_1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="39554" checksum="4FA6B3F498C470EE" modified="2011-10-19" version="1">MEHRAVSKARIEWLKKLLRAPLRSKEEHARTQAALERTFFFLSATGGSDWLQQEWDGRVEAMVNVMHARALRIMDTYLASPPLQESTSPASAPYSAAADHAPKVDARPRETDHREQRDRVRTIIKRNHTGPQRLSTSPQANGTGSNRSASIRIKILEHNQKRHRPDDDLSPSKRICVPLETPISQPTDVASTLVTYPPPSTPLCRRPRPLALPGTAGSFLSRSTAAPTGPPSSTVQNGTAQSPSSTPIHIFTQICKSQLNGYIDHCADAPVMHRCGKPIHLCKVWWTHERGNGPACPSGQGRGRTHLDNHGGKVIHERVTCKDVLKGKICPKINGGCEFAHDHEGYRRQIKNEKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ44</accession>
    <name>F9XQ44_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="F9XQ44">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ44"/>
    <dbReference type="GeneID" id="13401182"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77845"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.217"/>
    <dbReference type="eggNOG" id="KOG1741">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_0_1"/>
    <dbReference type="InParanoid" id="F9XQ44"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
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        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13509" checksum="5BED2283B73E6201" modified="2011-10-19" version="1">MAQFRPKRLDLSCFINNKIIRDHTKRKVFEQYEPERQALRYIIRNTSLPQRTRTQAQLQLTQMHCYTRSTQIKNRCVMGGKGRGILTDFRMSRYQFRMNALEGRLPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQQ3</accession>
    <name>F9XQQ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQQ3"/>
    <dbReference type="STRING" id="336722.F9XQQ3"/>
    <dbReference type="GeneID" id="13400558"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51617"/>
    <dbReference type="eggNOG" id="ENOG502SA8A">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060781_2_0_1"/>
    <dbReference type="InParanoid" id="F9XQQ3"/>
    <dbReference type="OMA" id="MIAYSPF"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22553" checksum="FB1078D94402196E" modified="2011-10-19" version="1">MPNGNQRHIRPSPAPIDKVSERIRNRENQRRLRERRREYTQDLEERLQQFEKKGIEATILVQRAARTVARENRLLRELLHSKGISEAEINQHVNYMIRPAAMKEEHVSTLCLASLEHIKVDAQDQSYYPSRNTSPIASPFPTSGRSNNDEMDCEEAARVITSLRGKVDPEALWPQLGCSTARRTRVKNSVLMTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR12</accession>
    <name>F9XR12_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82327.1"/>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Antoniw J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Torriani S.F.F."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="9">
        <location>
            <begin position="268"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="40620" checksum="B07B8BC65A36CCC0" modified="2011-10-19" version="1">MSHSSGEASPAVQAAEHAREVLFAEWQIKDENTAKFFGFAMAGLVAVFTITHQVDVLFTKEFARSSGSSTVARSMRRTLQLFSRSKIVAGVVLLPGKIVLALLYFGINAGLTFHDRPDRVGFNVLAKRFGWLALCNLCLVMFLGLKNTPLSPLAGRSFDQVNVLHRFCGYTTVALSIIHSVMLMIAVTAMGFVRRRQYEVFYAAHIVLVAIVLVAVGLHRPDIGLKALIITIVAAAMWFIDKSLRLSRWLYYGVGNYCTLTPLPGRATRITMHRSMRAQPGSMAFVWIPGVRMFQRHPFTLVSTEPAEFVVQARDGFTKELYHTACRNPGVKFRAALEGPYGVVPNTHEFDKIVLVAGGTRRVWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWB5</accession>
    <name>F9WWB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856085.1">
        <property type="nucleotide sequence ID" value="XM_003856037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWB5"/>
    <dbReference type="GeneID" id="13403131"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106995"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386466_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWB5"/>
    <dbReference type="OrthoDB" id="3638089at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="715" mass="79484" checksum="FCB749DFFB8A0FA8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWF1</accession>
    <name>GGS2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase 2</fullName>
            <shortName evidence="3">GGPP synthase 2</shortName>
            <shortName evidence="3">GGPPSase 2</shortName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyltranstransferase</fullName>
            <ecNumber evidence="1">2.5.1.1</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Farnesyltranstransferase</fullName>
            <ecNumber evidence="1">2.5.1.29</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Geranyltranstransferase</fullName>
            <ecNumber evidence="1">2.5.1.10</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GGS2</name>
        <name type="ORF">MYCGRDRAFT_34236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="631" last="631">
            <title>In silico prediction and characterization of secondary metabolite biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.</title>
            <authorList>
                <person name="Cairns T."/>
                <person name="Meyer V."/>
            </authorList>
            <dbReference type="PubMed" id="28818040"/>
            <dbReference type="DOI" id="10.1186/s12864-017-3969-y"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Geranylgeranyl pyrophosphate synthase; part of the gene cluster 3 that mediates the biosynthesis of an isoprenoid secondary metabolite.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17653"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="EC" id="2.5.1.1" evidence="1"/>
    <dbReference type="EC" id="2.5.1.29" evidence="1"/>
    <dbReference type="EC" id="2.5.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856214.1">
        <property type="nucleotide sequence ID" value="XM_003856166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWF1"/>
    <dbReference type="SMR" id="F9WWF1"/>
    <dbReference type="FunCoup" id="F9WWF1">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWF1"/>
    <dbReference type="EnsemblFungi" id="Mycgr3T34236">
        <property type="protein sequence ID" value="Mycgr3P34236"/>
        <property type="gene ID" value="Mycgr3G34236"/>
    </dbReference>
    <dbReference type="GeneID" id="13403008"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34236"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="InParanoid" id="F9WWF1"/>
    <dbReference type="OMA" id="FCEDIGE"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:mycotoxin biosynthetic process"/>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000451067" description="Geranylgeranyl pyrophosphate synthase 2">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>isopentenyl diphosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>isopentenyl diphosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
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        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
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        <location>
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        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>isopentenyl diphosphate</name>
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        </ligand>
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            <position position="181"/>
        </location>
        <ligand>
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        <location>
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        <location>
            <position position="218"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="1">
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            <position position="221"/>
        </location>
        <ligand>
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            <label>3</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
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        </ligand>
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        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="126"/>
        </location>
    </feature>
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        <source>
            <dbReference type="UniProtKB" id="Q12051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="36759" checksum="57069BBBE9943C40" modified="2011-10-19" version="1">MLDVRGSLPGQVNTGTISPYRRIDRSNDTIGTSDLAADEQVLLGPFNHLDARPGKEIRSQLIDAFDSWLQVPTASLAVIKNVVRMLHNASLLIDDIQDNSELRRGAPAAHHAFGTAQTINSANYVYFRALRELSTLHNPVMVQIYTAELLNLHHGQGMDLFWRETGTCPTESRYLEMVGNKTGGLFRLAIRCMCVEGSPKQSSADYIRLATMIGILFQILDDFRNLTDGSYTSSKGFCEDLTEGKFSFPIVHAIRSNPGDSFLHDILRQHTDDPAVKKEAVSYLERCGSLIYTQGVIHQLAGDVLTLADEVDAGQGRAQALKDIVQRLMVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWT8</accession>
    <name>F9WWT8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_66753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91482.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWT8"/>
    <dbReference type="GeneID" id="13399023"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66753"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
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    <dbReference type="OMA" id="AVNHMGH"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE BLI-4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36336" checksum="45B1784096B3069C" modified="2011-10-19" version="1">MSSIVNAAKATLSENLGGIAQSLAPAGTEFSLDDVPDQSGKVAVVTGGSAGIGYGATHTLLTKNISKLFILSGGEEKADTAHQAISKELGEEKASRVVLVHCDLGDWKSISGAAKKITDGTDRLDILIQNAGRGIMTYQLSDLGVDRHMAVNHFGHALLTSHLLPLLKKTASGQNVVRVTNQASNLHESAPKDTKFASLDELNTDLGPNGQYGRAKLANILFSRYLARHLTKEHPRILVNATHPGVVFTDMSQKDIHEPYPLLGYGMSVAAAPFKKDQFDGALSTLYAATVTHKSGEYICPPAAVEPGSELSQDEALQDQLMKLTREIIAEKMNGETLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXK3</accession>
    <name>F9WXK3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_88725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857739.1">
        <property type="nucleotide sequence ID" value="XM_003857691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXK3"/>
    <dbReference type="GeneID" id="13403841"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88725"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.164"/>
    <dbReference type="HOGENOM" id="CLU_960448_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXK3"/>
    <dbReference type="OrthoDB" id="10397821at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="290" mass="32076" checksum="C687F459CF6B4D53" modified="2011-10-19" version="1">MSNTTRTFEPTFEGKTLRELWAEQLPFVFDAPRRRAKATWTDNELIFVHFWYGKAGLWAIAWAIGRSYQALRNREHKFKKQVKNLDLAACPTKEVIIPGVRVPVDALREHLWREAPYEAAKAAETKVRLALNPRPKGNTRGLLPTKAKALGVKKTRGKKAAGKKTPTRKRSTATPVVAAAPASPLREANTDSAVWVDPITSRQYTGAEVRGGYLGLPAYQPPSMATMDATASAARGLLMLGQVNINSGSNNNGNAMGVSSRVSMEEAERERADEVARFRVFGPHGRPWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXQ7</accession>
    <name>F9WXQ7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_98257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856019.1">
        <property type="nucleotide sequence ID" value="XM_003855971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXQ7"/>
    <dbReference type="FunCoup" id="F9WXQ7">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXQ7"/>
    <dbReference type="GeneID" id="13403958"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98257"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.397"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXQ7"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391116" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="214" mass="24061" checksum="C416CF7DCF2AA201" modified="2011-10-19" version="1">MLALKLLAAFALPLVSALKFDIKADHTGESIMKERCIRNFAAKEQLVVVTIKTSGQRGDGQTLHVHIRDTVGNDYARPRDVAGESRHAFTSHADAPFDVCFENILTSQHPVIEPHRSVELDVDIGADAKDWSADAAGEKLKPVEAELRKISEQAKEVVDAMEYLRSREMKLRDTNESTNERVKWFALSTMGMLVALGVWQIVYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXZ4</accession>
    <name>F9WXZ4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857405.1">
        <property type="nucleotide sequence ID" value="XM_003857357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXZ4"/>
    <dbReference type="STRING" id="336722.F9WXZ4"/>
    <dbReference type="GeneID" id="13402976"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89322"/>
    <dbReference type="eggNOG" id="ENOG502SW29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1586334_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXZ4"/>
    <dbReference type="OMA" id="TNAWGRI"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21600" checksum="489CFE8C89195C34" modified="2011-10-19" version="1">MATNDFTPREDEIMAAAWRCFEGGEPKVDFKKLAPLVGMGNPGSAKNAWAKIKKKLAAAFEGEPKVDFKKLAPLVDMGNPGSAKNAWAKIKKKLAARALEVAGDTEAMTTTTSTPKPKATPKKRARSELKKEDTGSDDGDESPVKKVKATPKKGRGKKAVGELVGSDDEKVDERVDEVVGVEEVPVKAGAVDADHSVDTGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY51</accession>
    <name>F9WY51_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding protein of the histidine triad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HIT</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_32870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857274.1">
        <property type="nucleotide sequence ID" value="XM_003857226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY51"/>
    <dbReference type="STRING" id="336722.F9WY51"/>
    <dbReference type="GeneID" id="13402845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32870"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9WY51"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Crane C.F."/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91624.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="625" mass="69216" checksum="7760147B415D6CC1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYM3</accession>
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        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
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    </protein>
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        <name evidence="15" type="primary">MgGpa2</name>
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    <organism evidence="15 16">
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        <lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856727.1">
        <property type="nucleotide sequence ID" value="XM_003856679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYM3"/>
    <dbReference type="STRING" id="336722.F9WYM3"/>
    <dbReference type="GeneID" id="13398663"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84233"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="F9WYM3"/>
    <dbReference type="OMA" id="ANSHWFK"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP91703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="355" mass="40805" checksum="0B2DD97D73CCC61C" modified="2011-10-19" version="1">MCFGSSSKDDPEAKKSKEIEKQLREDQKRLDREVKLLLLGAGESGKSTVLKQMRLIHTKGFSSSERKQWKVTIFQNLVHAFQVVFGAMEEQEVEFADPSSVGFAELLAADPEIGPDDSMPNDCLHAFKNLWRDQGVQLAIRKGNEYALHDNLTYFLTDVDRLFARDYSPTDQDILRARLRTTGISETIFETGSLTYRMFDVGGQRSERKKWIHVFDNVQVVLFLVAISGFDHVLVEDRNGNQMHEALMLFESIANSKYFEKSALILFLNKIDLFREKVSSGRSLIREHFPEYTGADTDVDEGQQFFARKFKNLVRDPEKEAYVHFTNATDTNLLDKTMKSVQDMIVQRNLHNLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY0</accession>
    <name>F9WYY0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2 family DNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_88966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856040.1">
        <property type="nucleotide sequence ID" value="XM_003855992.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYY0"/>
    <dbReference type="GeneID" id="13403187"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88966"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9WYY0"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040934">
        <property type="entry name" value="Znf-CCCH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18585">
        <property type="entry name" value="zf-CCCH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="812"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1470"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP91016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1693" mass="191195" checksum="0020B82FDBDD445F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ83</accession>
    <name>F9WZ83_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_107205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857378.1">
        <property type="nucleotide sequence ID" value="XM_003857330.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WZ83">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ83"/>
    <dbReference type="GeneID" id="13394764"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107205"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.956"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="InParanoid" id="F9WZ83"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="337"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144044" checksum="5A0D121D8A6FDF75" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZN3</accession>
    <name>F9WZN3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_52069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855942.1">
        <property type="nucleotide sequence ID" value="XM_003855894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZN3"/>
    <dbReference type="GeneID" id="13403881"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52069"/>
    <dbReference type="eggNOG" id="ENOG502S2P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="InParanoid" id="F9WZN3"/>
    <dbReference type="OMA" id="SAWAAEM"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013436083" evidence="2">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="460" mass="47837" checksum="810AD711079A7A4B" modified="2011-10-19" version="1">MKTSTVKVALFALAGLVSAAPQGGVLGALLGAGGAKPIPPSDDPFYTPPAGFESAAPGTILRSRKVPSALSLFQAIPIQLQGAWQTLYRTTDSLGNPIATVNTIMVPKNADYTKVVSYQVAEDSGGEINCAPSYTLQTGSNTTYAGTGGIEAALIAAALNNGWVVTSPDWEGPLSTFVAGKQAGYATLDGVRSTLASGKITGVSSKAKVQMWGYSGGALASEWAAELQDSGYATEIPFVGMAIGGLTPDVKNVFSRINNGPFAGLSAAGFLGLGNAYPDFGQFVQDSLVPEKKDKFNEAGAQCFYADVVDYAGQDIFTYFKQGTEIFNDPLAISTIRKGATMGLTGTPRMPIFAYKSINDEISPIADTDALLKQFCDAGVSVEYVREQLGEHFTLATSSVGDELKFLKDRFAGKPVSGCTTRDSFNTILDPGNLENYGPAIVGVLLNAAGAPAGPLGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZQ1</accession>
    <name>F9WZQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_65137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857692.1">
        <property type="nucleotide sequence ID" value="XM_003857644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZQ1"/>
    <dbReference type="FunCoup" id="F9WZQ1">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZQ1"/>
    <dbReference type="GeneID" id="13403894"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65137"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016304_6_2_1"/>
    <dbReference type="InParanoid" id="F9WZQ1"/>
    <dbReference type="OMA" id="VRIFKMQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="300"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="437" mass="47248" checksum="274099A8DF8A9FFB" modified="2011-10-19" version="1">MSFPTFEGGAQAPQQGGEEQGGFGGAPGANQQPSPMGQQQMDPSQQQGQFQGGPQGAPPGPGGPQPGGDQKTTLWMGELEPWIDENFVRSVWFGMGYQVNVKMIRDKFSGSNAGYCFVDFENPDQATRALQLNGQVIPNSNRQFKLNWASGGGLADRSRDDRGPEFSIFVGDLGPEVNEYVLMSLFQGKYTSCKSAKIMSDPISGMSRGYGFVRFADEQDQQKALHEMQGVYCGNRPMRISTATPKNKSGAGGPGGMPGMGPPGGPGGNPNMGMYSMGAPPMGYYGAPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGTPYRPAPPPPVYPSMGMPPQHPYGNFAPMKVGYYPKIWLPMMKADESRSKRLFRPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZW9</accession>
    <name>F9WZW9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_89162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856155.1">
        <property type="nucleotide sequence ID" value="XM_003856107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZW9"/>
    <dbReference type="STRING" id="336722.F9WZW9"/>
    <dbReference type="GeneID" id="13394484"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89162"/>
    <dbReference type="eggNOG" id="ENOG502S18W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="InParanoid" id="F9WZW9"/>
    <dbReference type="OMA" id="PANCRIM"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391163" description="CPAF-like PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="641" mass="69039" checksum="A31272CBA4B41980" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0R1</accession>
    <name>F9X0R1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase</fullName>
            <ecNumber evidence="16">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">POLX1</name>
        <name evidence="19" type="ORF">MYCGRDRAFT_67412</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="16"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856936.1">
        <property type="nucleotide sequence ID" value="XM_003856888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0R1"/>
    <dbReference type="FunCoup" id="F9X0R1">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0R1"/>
    <dbReference type="GeneID" id="13398229"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67412"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008698_3_0_1"/>
    <dbReference type="InParanoid" id="F9X0R1"/>
    <dbReference type="OMA" id="KWHGASA"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="15">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP91912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="590" mass="66161" checksum="8796C56938D1D65C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0S6</accession>
    <name>F9X0S6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_102922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856753.1">
        <property type="nucleotide sequence ID" value="XM_003856705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0S6"/>
    <dbReference type="FunCoup" id="F9X0S6">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0S6"/>
    <dbReference type="GeneID" id="13398562"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102922"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1938"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0S6"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14900" checksum="9D78675D66AEC154" modified="2011-10-19" version="1">MSTSGKVKAAQLWGKNKDELQKQLDELKQELVQLRTQKIAGGAQSKLNKIHDVRKSIARVLTIINANQRSQLRLFYKNKKYMPLDLRPKQTRAIRRRLSPAEAKLVTEKQKKRQRHFPQRNFAVKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1E9</accession>
    <name>F9X1E9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_107551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856598.1">
        <property type="nucleotide sequence ID" value="XM_003856550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1E9"/>
    <dbReference type="FunCoup" id="F9X1E9">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1E9"/>
    <dbReference type="GeneID" id="13395383"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107551"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1585"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="F9X1E9"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="229"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP91574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="475" mass="52026" checksum="2A018E8E491B1F64" modified="2011-10-19" version="1">MGEPAQKFKVADINLAAFGRREIELAEQEMPGLVETRKKYADEQPLKGARIAGCLHMTIQTAVLIETLKALGAELTWTSCNIFSTQDHAAAAIAAGGTPVFAWKGETEEEYQWCLEQQLKAFPSGEKLNLILDDGGDLTALVHTKYPEMLEGCYGVSEETTTGVHHLYKMLKNKGKAGGLLVPSINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKISVVAGFGDVGKGCAEALHSMGARVLVTEVDPINALQAAMAGYQVVTMEEAAPIAQIFVTTTGCRDIIVGKHFEAMREDAIVCNIGHFDIEIDVAWLKKNAKEVVSIKPQVDRFLMPSGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQIMLYKAGDKNFTKKYVEFSRAIDEGVEGEPQLKKKEGDTVSQVERLPIGVYVLPKILDEQVALLHCAHVNVHLTKLTDVQSEYLSMPKEGPYKPENYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1H4</accession>
    <name>F9X1H4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_32934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856767.1">
        <property type="nucleotide sequence ID" value="XM_003856719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1H4"/>
    <dbReference type="GeneID" id="13398544"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32934"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="F9X1H4"/>
    <dbReference type="OMA" id="DHKMVTH"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="364" mass="38879" checksum="9E12D52177CEC256" modified="2011-10-19" version="1">MPSLPDTQSLVIQKKNVELPPDRLPLAVVDGKPVPQIRGDHDLLVRVLAVGLNPVDSKMVAHFFMEDTPTGCDFCGVVEMAGSASNIPVGTRIIGGELPYRPNNHYHGGFAQYAVTDCRNALVVPEDWSDTVAAGLGNLSWATVGLAMSKAEALNLEGTPSNPAAKALPVLVYGAGTATGVIAIQMLKQSGYSPIGVCSEKSSERAIACGAVGTACYTSPDCTKRILELAAGVPIKHALDCITQPETVEMCFQVLARVGARYACLENCLESWRSRRSVKVSVVMGYEQLPYDIDLDDPVYSRKTNPHSVQIARTWGAEVQKMVNEGSIAPLPVEELEGGLGAIIDGLETIRKGQVQGKKLVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2C9</accession>
    <name>F9X2C9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_68526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855492.1">
        <property type="nucleotide sequence ID" value="XM_003855444.1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68526"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.709"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="F9X2C9"/>
    <dbReference type="OMA" id="FFGIRGI"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP90468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="558" mass="60924" checksum="978A61025E3A52D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3F4</accession>
    <name>F9X3F4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">qa-x</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_54764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854767.1">
        <property type="nucleotide sequence ID" value="XM_003854719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3F4"/>
    <dbReference type="STRING" id="336722.F9X3F4"/>
    <dbReference type="GeneID" id="13395952"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54764"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.169"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_1_1"/>
    <dbReference type="InParanoid" id="F9X3F4"/>
    <dbReference type="OMA" id="QTIHYGR"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000019">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF39">
        <property type="entry name" value="PROTEIN QUTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="335" mass="36270" checksum="729C835DFBA04208" modified="2011-10-19" version="1">MTSMAPAISDAELDEIHAFAVQLAKDAGQMLLDAVDARMGKNGQATHEEKESAVDLVTQTDEDVEAFIRKSVQSKYPSHAFCGEESYGKGGSKDYLIPSTGPAWCVDPLDGTVNFIHLAPFYCVSIAFLWNGEPVVGAINAPFLRQLFTACRGRGAWLNETTQLPLNRNPIPPLPETAPKGCVFSCEWGKDRRDIPDGNLHRKINSFMNMAAELGSRGGKGGMVHGVRSLGSATLDLAYVAMGSFDIWWEGGCWEWDVAAGICLLKEAGGLVTTANPPATIDGAAVPETHLGSRLYLAIRPAGDSATETGRQTQERTVREVWKRVETLDYTRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3K5</accession>
    <name>F9X3K5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_30411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3K5"/>
    <dbReference type="STRING" id="336722.F9X3K5"/>
    <dbReference type="GeneID" id="13403582"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30411"/>
    <dbReference type="eggNOG" id="ENOG502S6B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036503_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3K5"/>
    <dbReference type="OMA" id="LAFWMNA"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27490" checksum="A8FA596C9E8499BE" modified="2011-10-19" version="1" fragment="single">QPSLIVICSWMNAAEKHIAKYTAGYRRLYPDTTVLLVQCSLAGFFTSKAKQEVLLKPAYDMIINHRSDGNQGGPVVLHAFSNGGGTLANYIAGFLNERSPGKKVVFNKVILDCLPGIPTIAGAVRAVSFSLPRNPILRFLGQWIFRIWLVAYSIFAYALRRREDRVTRLRRRLNDPERFDLGAPRLYLYSKADDLVEHWAVAEHAEGARKKGYRVREELFINAPHCAIAKDEPERYWKAVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3N0</accession>
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        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
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    </protein>
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    <organism evidence="7 8">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="165"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="440"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89928.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="676" mass="73590" checksum="8A51B8899AA8DF19" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3P4</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
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    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855530.1">
        <property type="nucleotide sequence ID" value="XM_003855482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3P4"/>
    <dbReference type="FunCoup" id="F9X3P4">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3P4"/>
    <dbReference type="GeneID" id="13399598"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68429"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.618"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_3_1"/>
    <dbReference type="InParanoid" id="F9X3P4"/>
    <dbReference type="OMA" id="GMTCKLA"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="419" mass="46920" checksum="723720499F3D4379" modified="2011-10-19" version="1">MLPTPPPSPKPLSVCHPEDRIGHLLAGTIQLTGILGVGAYGTVYKAHDIETDVQYAVKALNKVGLDPRQQKFQDREIQLHYAASQHPNVVSLVKILDSPECTYVVIEYCPEGDLFSKITEEGHYVGDDFKAKQVFLQILAAVQHCHSRGIYHRDLKPENVLVMDNGWTVKLADFGLATQERVTSDFGCGSTFYMSPECQNSNPKPYSCYASAANDVWSLGVILVNLTCGRNPWKRASMEDSTFRAFMRDRNFLQSILPISDDLNHLFQRIFEVDPTRRITLDELREYIIRMPRLTTQECSAPAAAPVTPPYSPLNKPVDSPPAVVISNPAYEPVPHLDLPAQQYPATDFYQQNSALYTPPSSGPCTPQPTNLYTSTHHQQKPPVVYPSSPFFANLPDFRRCGHLLSSFQFPQHAWAATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q4</accession>
    <name>F9X3Q4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKY1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_84644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854963.1">
        <property type="nucleotide sequence ID" value="XM_003854915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Q4"/>
    <dbReference type="FunCoup" id="F9X3Q4">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3Q4"/>
    <dbReference type="GeneID" id="13403465"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84644"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="InParanoid" id="F9X3Q4"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="573" mass="63622" checksum="E61A9FB9F71DCEC4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X433</accession>
    <name>F9X433_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_35614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855180.1">
        <property type="nucleotide sequence ID" value="XM_003855132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X433"/>
    <dbReference type="STRING" id="336722.F9X433"/>
    <dbReference type="GeneID" id="13400534"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35614"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_2_0_1"/>
    <dbReference type="InParanoid" id="F9X433"/>
    <dbReference type="OMA" id="CRSHQNE"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="182" mass="20028" checksum="B0950D5DAAB257E1" modified="2011-10-19" version="1" fragment="single">TSEVQGTKEVANAALGDFDIAFKLEDGQVLSAPGPVGNPMWRSPEAQVGCGLTMASDIFSFGLVCLYAMGAGDMLIIDPKVLEFLGMSPEEEVLSRHVEYFGPASDVLYKRIGNEAGRAFLKKTINASTVPYETDPERRLTHWEEDLGPVALDIIGRMTSMDPPARPTITEILEHAWWREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4E4</accession>
    <name>F9X4E4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855512.1">
        <property type="nucleotide sequence ID" value="XM_003855464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4E4"/>
    <dbReference type="GeneID" id="13403452"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90811"/>
    <dbReference type="eggNOG" id="ENOG502RJET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694422_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4E4"/>
    <dbReference type="OMA" id="DITWQRI"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="379" mass="42368" checksum="C447D97A247CA3AE" modified="2011-10-19" version="1">MERLQHRTLLQAAQEGRFAAQDSELHIFHSDTDLKSSHEEVHQSACEEKDHLPPTFTSGLNGCNGPGSRLRLLLQRSRPPHTSGKPDSLPFASAASLNTIFETLNLPGSYLQIADGFLSTAQAHITNDAKRDAIAFQLIVYCTMKQGDWSLALSHRASTMDTAVFCSLDQKLNGQHLVDDLQSLQQYSFHPMVIPCIMFETVLNMGIERRNSIKSRLQTLEHTMTQMSREATSESLVDVGSESDQQDSWIQLSDLLASCRRDQLGLKYTHEILLSAAVPNDAQSEVHAELRQWVDLTWQKLNSLMARDKDHINRVENVSTLLYSLVQQRDIRLQSSIAKATQRDSRDMKFIAVLGSVFLPASLVAANGTLDLRRATSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4F2</accession>
    <name>F9X4F2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 14">Cutinase</fullName>
            <ecNumber evidence="3 14">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MgCUT2</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_68483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 14"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855507.1">
        <property type="nucleotide sequence ID" value="XM_003855459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4F2"/>
    <dbReference type="ESTHER" id="zymti-f9x4f2">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="GeneID" id="13399617"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68483"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.663"/>
    <dbReference type="eggNOG" id="ENOG502SI38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="InParanoid" id="F9X4F2"/>
    <dbReference type="OMA" id="PPVIFIY"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
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    </dbReference>
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        <property type="entry name" value="CUTINASE"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4 14" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130648" description="Cutinase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074522"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP90483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="21764" checksum="9506F55550B2EBBF" modified="2011-10-19" version="1">MKASTIVALLAGLVSAAPADVDRRQIGSSTSNELTSGACRDVIFIFARGTTERGNMGSTVGPQTCSALKSRIGSTSVACQGVGSPYAADVTGNFGTRGASTVGIAEGKRLFDLAASKCPNSQIVAGGYSQGAALIAASVTDVSAAVKAKIAGVVLFGYTKNQQNRGVIPGGYPASQTKVYCNIGDLVCTGSLTITAAHLTYGRDASSAAQFLQGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4M6</accession>
    <name>F9X4M6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_68826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4M6"/>
    <dbReference type="FunCoup" id="F9X4M6">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="GeneID" id="13400040"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68826"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.913"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="InParanoid" id="F9X4M6"/>
    <dbReference type="OMA" id="LLMAQYT"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="299"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="349"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="404"/>
            <end position="425"/>
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    </feature>
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            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="541" mass="57794" checksum="22FC5D081BF0758D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X500</accession>
    <name>F9X500_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_103519</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855221.1">
        <property type="nucleotide sequence ID" value="XM_003855173.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X500"/>
    <dbReference type="GeneID" id="13400474"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103519"/>
    <dbReference type="HOGENOM" id="CLU_2028545_0_0_1"/>
    <dbReference type="InParanoid" id="F9X500"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13937" checksum="5BB1F035B1B97B09" modified="2011-10-19" version="1">MITSFTHYYSPGFLANIMTTTFIIFISLRFLNGHVMERELLRNSFPVAFTTTCFTRFFSPNFPTGIIATSFIISLSLEVKQTDTLSIAAANASSEFCWRHQHRLESQQTDSEKRSQVLVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X517</accession>
    <name>F9X517_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="13404167"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108605"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.501"/>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="InParanoid" id="F9X517"/>
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    <dbReference type="OrthoDB" id="5819582at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
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            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
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        </location>
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            <end position="535"/>
        </location>
    </feature>
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            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP88804.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="580" mass="66726" checksum="FF383BE4BB0AF1F3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13395467"/>
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    <dbReference type="eggNOG" id="ENOG502S5H8">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043071_0_0_1"/>
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    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="293"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="368" mass="41550" checksum="6FC7BC571F2DBD96" modified="2011-10-19" version="1">MDENARKLDAHDKDPQPAISNNPFETHGPNKVIFAYLSSRFETFRRLTAIRDKGWLSSKGDEHFKKQRATADKNTAQAKKGFFNCMIQNGNELQVLTGGFNITRTSPPPERILDLCMAPGAFLQVALEFNPSATAKAFTLPVESGGHATRIKSHTRFGGRVDLTYQDITLMAADMGVTTIPTSHPDAASLLTVRQIPADELFDLVICDGQVLRGHDRAEWREQNEARRLVSTQLALGLEHLRESGTMIVLLHKIERWEVLKLLYHFNKFSDVSVFKPERIHASRSSFYLVAKKVQSQSEAARAVLQEWKKEWEVTTFGTAEEIEEVLRKDDEKVKEVLEEFADKLGGLGEIVWGIQANALETSKWMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X638</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG2793">
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28101" checksum="8FF28E26274CC20E" modified="2011-10-19" version="1">MKFRSLKSPFNITNDATTNSKLLIHISEKEGVKAENLSLATWGSSYVLANHLHRWKDTQPIHTARENTSNSIAVLELGAGTGLVGLSAAAIWQLPVILTDLAPIVPGLAQNINSNRALLAEKGTTAACGCLDWTQPEELLLSNPVLAASEPQIVQSSRKAHIILAADVVYSEDHPELLLKTILAWLAPGPDARVVICYPVRIAYIDHIRDLWERFEAAGLLCVEEAQESSDDDWGEAEPAPYEFCMWAWKREEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X679</accession>
    <name>F9X679_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854508.1">
        <property type="nucleotide sequence ID" value="XM_003854460.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X679"/>
    <dbReference type="GeneID" id="13395695"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91559"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.343"/>
    <dbReference type="eggNOG" id="ENOG502RXDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253599_0_0_1"/>
    <dbReference type="InParanoid" id="F9X679"/>
    <dbReference type="OMA" id="NTIPWEM"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1412" mass="154184" checksum="46EECD674852ADD2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6K5</accession>
    <name>F9X6K5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_91389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854618.1">
        <property type="nucleotide sequence ID" value="XM_003854570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6K5"/>
    <dbReference type="STRING" id="336722.F9X6K5"/>
    <dbReference type="GeneID" id="13395804"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91389"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.123"/>
    <dbReference type="eggNOG" id="ENOG502S3TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_1_1"/>
    <dbReference type="InParanoid" id="F9X6K5"/>
    <dbReference type="OMA" id="NGPNEFH"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="56"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="331" mass="36685" checksum="7C3B544565D137F0" modified="2011-10-19" version="1">MTYNIPDENTPKPPGQTRPYPQPTTTGEIDFTVPSTGEQVKTAYKIWGTLSPTTTPLICLHGGPGMLHNYMLPISLLATDTPTPVIMYDQLGCGLSTHLRHHNASPEFWTPALFIAELENLKSALGISSFHLLGQSWGGMLAAQYVIEVQPKGLRKLVICNSPANLTTWAKVCTALREALPREVREVLDRCEREGTTDGKEYQGATYAFYRRHVCRVDPFPEELVASLDGVAEDNTVYGTMNGPSEFTVVGSLKGWDITPGLGRISEEAVPGGVLLMNGKWDEAQDETMEPFEKGIGARVKWVRFGLSSHTPMLEETEEFLRVLREFVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6R2</accession>
    <name>F9X6R2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_99493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854495.1">
        <property type="nucleotide sequence ID" value="XM_003854447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6R2"/>
    <dbReference type="FunCoup" id="F9X6R2">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6R2"/>
    <dbReference type="GeneID" id="13395682"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99493"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.364"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="F9X6R2"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="205" mass="22798" checksum="FCE6C5ADD348AB33" modified="2011-10-19" version="1">MSSRKKILLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTKEVLVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFDTLDSWRDEFLIQASPMDPESFPFVVLGNKVDVEESKRMISSKRAMAFCQAKGGIPYFETSAKEAVNVEQAFEVIARNALAQEESQDFDPDFPPTIPINIGENEQGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6T4</accession>
    <name>F9X6T4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854482.1">
        <property type="nucleotide sequence ID" value="XM_003854434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6T4"/>
    <dbReference type="GeneID" id="13395669"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91598"/>
    <dbReference type="eggNOG" id="ENOG502SVM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068958_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6T4"/>
    <dbReference type="OMA" id="DSFALYS"/>
    <dbReference type="OrthoDB" id="5397846at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="38686" checksum="AB94CF12770C2F09" modified="2011-10-19" version="1">MPHVGTASRHASPACLAALHFTICTIHHLANAITKPNHTFAASMADSTKTTRSSKRKRTQVSYSADDYFDSLDMEGNGTATKTDIAPDAATFDTTSDNNDDDDEPEDGEFTRKAYSQELRDEIYDLCLTEPDGLLLVSKRRGARKTVARGSVTTQTGTHYHGKYRSGGYRGWRRYYYGNEDRPETTNFGSRSRRFVPALLAVNKQMREEGSSRLYKQEIALEDTTALFNFIATIGDHNRQMVSNLTIKGWGQGNLQAHRDPADLADTFYRAAHFFLEALVDAKGDVDAAVDVIQLAEWHFDKTRVTPPTLQSAASGSAVEYKPVTEVEKQFQDELRKLLVARCRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X0</accession>
    <name>F9X6X0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TH2</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_70038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854356.1">
        <property type="nucleotide sequence ID" value="XM_003854308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X0"/>
    <dbReference type="STRING" id="336722.F9X6X0"/>
    <dbReference type="GeneID" id="13404255"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70038"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.679"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="F9X6X0"/>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="294"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="413" mass="43348" checksum="43A3B612B11BEF34" modified="2011-10-19" version="1">MAGFVQKGTKNILTKSPTDIVFLSALRTPVTRAKKGGLAQAYDHELLAAVLSATLKATPNLDSALIQDVHIGTVLSELGGSKAGRMAALHVGYPETSSFQTVNRACSSGLSAITGVAHAIATGQIDIGVGGGMESMTRNYGSRAIPTQLWDGLKESQVKEARDCVMSMGLTAENVAERYGVSREEQDKFAANSHVKAAKAQSEGLFDKEIVEVKTRRVPDPEHPESVEEITVTKDDGIRPQSTAEGLAKMKPAFKPDGTATAGNSSQVSDGAAAALMMRRSTATALGLEGSIIGKWAGTQVVGCRPDEMGIGPAIAIPRLMEYTGVDKKEIGIWEINEAFASQAVFCVRSLGIDESKVNPKGGAIALGHPLGATGARQLATLLPEMERQGQELGVISMCIGTGMGMASLIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X7</accession>
    <name>F9X6X7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854353.1">
        <property type="nucleotide sequence ID" value="XM_003854305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X7"/>
    <dbReference type="GeneID" id="13404258"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91843"/>
    <dbReference type="HOGENOM" id="CLU_287165_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6X7"/>
    <dbReference type="OrthoDB" id="3648865at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119321" checksum="3C7ED37C662F84D1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X725</accession>
    <name>F9X725_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_70436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="251"/>
            <end position="408"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="55"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="178"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
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            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="560"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="305"/>
            <end position="317"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
            <position position="308"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="661" mass="73146" checksum="E26ABF3087FB6F90" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7P2</accession>
    <name>F9X7P2_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_103608</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
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    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:secondary metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP89536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="467" mass="52079" checksum="822EBF40BD660365" modified="2011-10-19" version="1" fragment="single">MPFLAKEHFPLSNKDILSWTFDNLNYDWDSPIYIDALNPSRSISARQARTMARQLAAGLKKIGLKKGDCVSIHSANDIYYPIFFLGVIAAGGVYAGTNPGYTIHELEHTTRIAKVKFIFSQPELMDNIVKAADANGIKKENLVVFNPHGEKAPPGFLQWKDLLQHGEVDWERFDDYETAYQTGAARLYSSGTTGLPKAAELSHLNLTAQHMLVYEHNPKPYKVRRLCALPMFHAATAPNIFCTPLRNGERCYVLPKFDLEKWFWAHGEYQITDFGAVPPIVIMAINSPLKDKYSFKSVKAGQIGAAPLDKGPQARMQALLGKEAPFTQVWGMTETSCIATRHKYPSHDTTGSVGVPLANLDLKLVDDDGKDISDYGVRGELCVRGPTVIKGYYDNPEANARDWDEDNFFHTGDIGWVDPDTKLYYIVDRKKELIKVRGFQVAPPELEGVLLSHPEIVDAAVIGVPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X811</accession>
    <name>F9X811_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_39401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854156.1">
        <property type="nucleotide sequence ID" value="XM_003854108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X811"/>
    <dbReference type="GeneID" id="13404475"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39401"/>
    <dbReference type="eggNOG" id="ENOG502SJ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_1_1"/>
    <dbReference type="InParanoid" id="F9X811"/>
    <dbReference type="OMA" id="LANWEFL"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="74"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="422" mass="47715" checksum="B3EFE67FC69A773E" modified="2011-10-19" version="1">MANLQQIQSRGIFHGLPVYPPEISGLTAVITGANGISGHYMLRVLTKDPKRWKRIICLSRRPPLSPAHVEHIPLDFLKDPEDIAQVLKEHKVQADHVFFFSYIQPTPKPGAGLWSNAEELVKVNTQLLHNFLEALKLAPITPKRFMLQAGAKNYGGHLGPTKVPQEETDPRVELEPNFYYPQEDLLFQFAADTGCGWSIHMPGPIVGAVPDAAMNCAFPLAVYASVCKKLGVPLEFSGDIASWQMPQSMSAAQMNAYQEEWAVLLGPANQKYNTCDNSSFAWEKVWPRIAGWYGIEWKGPQDGDVYTENESRFNPRGYGPKGVTRRKFRMVDWAKREDVQRAWKELVQEYGLTQELKDVDRIFGFLDGTLCRPAPLMFSMDKARKHGWHGFVDSSEAILEVFQDFERLKMIPPVPLVKVSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X813</accession>
    <name>F9X813_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_108908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854154.1">
        <property type="nucleotide sequence ID" value="XM_003854106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X813"/>
    <dbReference type="ESTHER" id="zymti-f9x813">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13404495"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108908"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1123"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="F9X813"/>
    <dbReference type="OMA" id="ETWAANG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130632" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="32"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="570" mass="62123" checksum="1FEA163274235303" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X839</accession>
    <name>F9X839_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_108932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853587.1">
        <property type="nucleotide sequence ID" value="XM_003853539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X839"/>
    <dbReference type="STRING" id="336722.F9X839"/>
    <dbReference type="GeneID" id="13397136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108932"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.55"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="InParanoid" id="F9X839"/>
    <dbReference type="OMA" id="LCPEYRY"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56164" checksum="709AB37113F293FC" modified="2011-10-19" version="1">MDSSTFRAAGHRAIEYIADYYEQLASGPVRSDVTPGFLLSKLPSEAPEKSEAWSAIESDLHHLIEPGLGHWMHPGFMAYFPASSSFEGILGELYSAAFNNPAFDWICSPSITELELAMGVWVGELLGLPPSFRGHASSVIQSTTTECLITTMCAARERMVNAIVAEGDYETERLRSDDVRNRLVVLSSSETHVSTRKAAKVVGVQHRSIPCDPSDGIALSGTQLQTAVDECLAEGMIPFYFTAAFGTTNSCAVDDFPGIARVKEKHPEIWIHVDAAYAGAALACEEFRPLASGMDQFDSFSVNMGKWLLTNLDCTMLFARNRSDIVCSMKNDCSILQNPVSTSQKTTDYRDLQLSMGRRFRSLKVWFVLRSFGKQRIQHHIRRHVEMASHFTDWVRQRPDLFALTTEPRFALNVIRVSDAAASRMGTDSSSATAKLYDVISQSRRFWLSKTTINGCVSIRIIAANSNSDLDTLRHVFEVLSEGTQSLLDQSAIRSDGEDDGKRCTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8A6</accession>
    <name>F9X8A6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_39970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853506.1">
        <property type="nucleotide sequence ID" value="XM_003853458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8A6"/>
    <dbReference type="GeneID" id="13397230"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39970"/>
    <dbReference type="eggNOG" id="ENOG502S415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8A6"/>
    <dbReference type="OMA" id="RNGCCDT"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="13106" checksum="06804500617E3344" modified="2011-10-19" version="1" fragment="single">VFKQPLSLHSTSPMTGFLRNGYCEVPSSDFGNHAVAAEVTEEFLTFSAAQGNDLRVIPGMKAGCKWCLCASRWLEAFEARGREKDGDKIVPKVWLKATNEKALGKINLEDLKAFAKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8B3</accession>
    <name>F9X8B3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_85608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852911.1">
        <property type="nucleotide sequence ID" value="XM_003852863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8B3"/>
    <dbReference type="GeneID" id="13397232"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85608"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="F9X8B3"/>
    <dbReference type="OMA" id="APEMRLW"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69338" checksum="CB932D81C243AEF3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8G5</accession>
    <name>F9X8G5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_71192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853017.1">
        <property type="nucleotide sequence ID" value="XM_003852969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8G5"/>
    <dbReference type="FunCoup" id="F9X8G5">
        <property type="interactions" value="940"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8G5"/>
    <dbReference type="GeneID" id="13400212"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71192"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.478"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8G5"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="335" mass="36848" checksum="4ED368399204EA64" modified="2011-10-19" version="1">MADDEMDPSLQSIVDQKSLKWIFVGGKGGVGKTTTSCSLAVQMARARKSVLLISTDPAHNLSDAFGVKFGKDARPVPGVEGLAAMEIDPNGSINDLIKAGGDDAEEAMAGLGGVGSMFQDMAFSIPGVDEAMSFAEVLKQVKGMEYELIIFDTAPTGHTLRFLQFPTVLEKALGKLSQLSQQFGPMINNLIGARGGLPNGQSFDDVLKRMNDLQDTISEVNKQFKNPDLTTFVPVLIPEFLSLYETERMIQELGTYEIDTHAMVVNQLLFPKKDNPCEQCNSRRKMQKKYLEQIDDLYGEDFHVVKMPLLVDEVRGVESISKFSEMLVKPFVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X936</accession>
    <name>F9X936_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853048.1">
        <property type="nucleotide sequence ID" value="XM_003853000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X936"/>
    <dbReference type="GeneID" id="13400184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92654"/>
    <dbReference type="eggNOG" id="ENOG502SITX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062061_0_0_1"/>
    <dbReference type="InParanoid" id="F9X936"/>
    <dbReference type="OMA" id="DMRHEIQ"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="392" mass="43509" checksum="75CE73FE16B8C2C9" modified="2011-10-19" version="1">MLADIGAQNKNVDSNGPSPDNASSARRQPSTPLVPDPIETPAGAGQLLSLTPSTESDAVAMGLLSTEAARTLLQRFKTTLTPHFPFVVCYRRLAHFPDKYILPIVQIQHTMEQADASDHDEREVLKSTHLTQLILCLETIKGALLFPLAESAMLTMHLHTGIVHACHTNVCTDAALNLLPTDERWPQWRLDALSTGLIAAKSSLSCFLSLPLGHEKSFNNSEWIQLGFVTTCAARLAALSSQKVIRQETHHLRRFLGISDGLKDTIRRLESLSTSTADDDGERDVFYHYRQRVQRIQAWFQAQQERVQRESMQTVSDTADAAAWNGSARQQLPLASSGAQRAWNPGQALPQDSPVLPMDIAWREGDLFDWLPDDLMDMENFGQTFPFDAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9F9</accession>
    <name>F9X9F9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEP-S10.3</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_99840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Extracellular serine carboxypeptidase that contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="14"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852894.1">
        <property type="nucleotide sequence ID" value="XM_003852846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9F9"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="13397215"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99840"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.211"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="InParanoid" id="F9X9F9"/>
    <dbReference type="OMA" id="QTWFFEF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130650" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="642" mass="71080" checksum="2D7EF473EA9654A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9S2</accession>
    <name>F9X9S2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853085.1">
        <property type="nucleotide sequence ID" value="XM_003853037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9S2"/>
    <dbReference type="GeneID" id="13399298"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92716"/>
    <dbReference type="HOGENOM" id="CLU_759123_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9S2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="365" mass="38091" checksum="DFA0C788FC5D5873" modified="2011-10-19" version="1">MALGKSRLSLAGKQALKQSTCPKVSRPAFLTTANPTRTRNAVLTHTTNAVRKSAAVKTAIPIFPVWYDMPTPQGVILPPAFPVISGKLPGLPKCKDLCDDITCKILGCGADVCGILACGGFDTGIFGKILPKIGCKNIIIKVSCKLFKIGCCKKDTDEDIPEPCSGKNCFEDGGDPIAIDGGDNGDPEDPDDEDEECETLTTSHLTASCTFLTDAGTSTQTSCTSIYETITGCDVTGVTSTYATTACINTNTRATDVSVSCFATNVTTTGGTTIQGSGTCTAVSSSVRTGCDLTGTTTSITSFAEEQCDHKPSDVDVELATVDMKMLRRSESSEATVTGETLAAAATTTAAISTRGKKWWAAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Z4</accession>
    <name>F9X9Z4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_71387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853088.1">
        <property type="nucleotide sequence ID" value="XM_003853040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Z4"/>
    <dbReference type="FunCoup" id="F9X9Z4">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9Z4"/>
    <dbReference type="GeneID" id="13399993"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71387"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.623"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="InParanoid" id="F9X9Z4"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="226" mass="24929" checksum="B8FCE12B823C16D3" modified="2011-10-19" version="1">MSTAPLRLGSIAPNFDADTTSGPINFHDFIGDSWVVLFSHPEDYTPVCTTELGAFAKLEPEFTKRGVKLIGLSANTVESHGGWIKDINDISGSQLKFPIIGDKERKVALAYDMIDHQDATNVDEKGIAFTIRSVFIIDPKKTIRLILSYPASTGRNTAEVLRVVDSLQTGDKHRITTPINWVPGDDVIVHPSVKSPEAEKLFPKMNVVRPYLRFTPLPKEETSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA14</accession>
    <name>F9XA14_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_41229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853313.1">
        <property type="nucleotide sequence ID" value="XM_003853265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA14"/>
    <dbReference type="FunCoup" id="F9XA14">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA14"/>
    <dbReference type="GeneID" id="13399309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41229"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA14"/>
    <dbReference type="OMA" id="YSEHYFN"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="168" mass="18458" checksum="480E2FE31C737772" modified="2011-10-19" version="1">MRMISTSKASMAGLMPDSEDPEPPTVKATEAPPAQPTELSDEAYATVAEEYMELVHEKAEQIQETREDVEVEYSAGVLSITFPPAGTYIINKQPPNKQIWLSSPISGPKRYDWVIEGEGMHQKEGGGTGEWVYLRDGTNLTELLGEELGIHIYAQAGEEMKGSTDPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA80</accession>
    <name>F9XA80_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_71143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852994.1">
        <property type="nucleotide sequence ID" value="XM_003852946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA80"/>
    <dbReference type="FunCoup" id="F9XA80">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA80"/>
    <dbReference type="GeneID" id="13400234"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71143"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.431"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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            <end position="534"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <ligand>
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        <ligand>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="548" mass="59991" checksum="94162EFCCF2EA423" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    </feature>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.190"/>
    <dbReference type="HOGENOM" id="CLU_1409830_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB95"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391521" evidence="1">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="193" mass="20205" checksum="C258E549C57F899F" modified="2011-10-19" version="1">MHFSHAILFLASALPAVVLADTTGSRIAVPIAAGPGNTKRSFSPLLRMLRRDDPQPASCTAPDDTPCLPKGVAPHTPHTCNIPLTNSPAYIGLDAVRRNGYPSCSSSNTCSCSAIGVPHDVLIEICREIISRQDPSLHVVDACASGPTGEDGHCDLAGPTYPDFSGTDVTVYNGWVCKNGKYVGEHTPSGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBD8</accession>
    <name>F9XBD8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enol-lactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ELH</name>
        <name evidence="2" type="ORF">MYCGRDRAFT_93354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852545.1">
        <property type="nucleotide sequence ID" value="XM_003852497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBD8"/>
    <dbReference type="STRING" id="336722.F9XBD8"/>
    <dbReference type="GeneID" id="13396867"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93354"/>
    <dbReference type="eggNOG" id="ENOG502QPPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_1"/>
    <dbReference type="InParanoid" id="F9XBD8"/>
    <dbReference type="OMA" id="YSMGGWI"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF20">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="51"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="280" mass="30457" checksum="E71D7E6D70A20F66" modified="2011-10-19" version="1">MHQALRAIGSAFGRRGELGVAKPKLYRSSPSIDTARNEQCHSSTEQAFVYSSMWGGQIEPLSKRFRLIVWDMRGHGKSGYPSDPSAYSEAHTVEDIGLILDANCTPDTKAIVGGLSLGGYMSLAFYRSYPKRVCALLIIDTGPGFKKDSAREEWNRTAIKTAEELEKDGLKALHRQSPERSRASHRNAEGLALAARGMLTQRDSTIIESLVRVEVPSLVVVGAEDKPFLVASEYMAKKIPGAKKVVVPGAGHAVNIDQPKAFMQAVVPFLGQFASSKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBF7</accession>
    <name>F9XBF7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF3328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_93372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852535.1">
        <property type="nucleotide sequence ID" value="XM_003852487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBF7"/>
    <dbReference type="STRING" id="336722.F9XBF7"/>
    <dbReference type="GeneID" id="13396857"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93372"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.566"/>
    <dbReference type="eggNOG" id="ENOG502SR3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_0_1_1"/>
    <dbReference type="InParanoid" id="F9XBF7"/>
    <dbReference type="OMA" id="LHIDHCI"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="30203" checksum="118C89DCB55E9510" modified="2011-10-19" version="1">MKYSLLKPESQAMEERGHDEQEPSHDPWKQRFTILNIVLFFFSASLLLLAVRIEDARTPRDDLGYQRLYSPIWSAVEYQKKVFYADVEANKKYVGQPRPELDEAWANITEGHLILLNETGVRALGQSLDEAVSLEGKYFALPEYYHQMHCLDIIRRSFWREHYSDFKVFQFSEEAIMGHIDHCLDLLRQMIMCTADVGLIIYYWEGADREPQAKFATEHMCRNLDRINDWVLEHKWEDEVTFDPLDPHMMLSHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBI3</accession>
    <name>F9XBI3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_72424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852287.1">
        <property type="nucleotide sequence ID" value="XM_003852239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBI3"/>
    <dbReference type="FunCoup" id="F9XBI3">
        <property type="interactions" value="1129"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBI3"/>
    <dbReference type="GeneID" id="13394063"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72424"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.592"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="InParanoid" id="F9XBI3"/>
    <dbReference type="OMA" id="WFRLWAE"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="42441" checksum="31FFFD1FAC11B83A" modified="2011-10-19" version="1">MTSNNGFHRFSHGHQDLLLAVSYNFYGTRMASASADHKVKVWDRNDQTGQWIVTDVWTAHDAEVTDVKWNGPFVGEHLATIGEDGLFKIWQEDVNEPPNSGRRFKPIFQQSTSTGVPYASLDLKNIAAETYLAMITRDGYLTICSPEDHDDLSAWRVMWSDYLVPTPPRTEETAFRLSWHKEKIPAWPAVLAGLDRKSLSLAVAVGTSVRVFRTDKDRKFYTAAVLDGATELVRDVDWANGSMRGFDAIATASKDGHIRIYELHTPGASSLPTSLAGSVAGDNETSHNTSSPSISKPSTTTRSGIGAGLALGARGSRDENARAPGAVKQEAKLVAEIAAHSHVPWRVSWAPMADMLLSTGDDGCTRIWKKSVEGKWAEAAEIDVFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBU2</accession>
    <name>F9XBU2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_72479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852305.1">
        <property type="nucleotide sequence ID" value="XM_003852257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBU2"/>
    <dbReference type="GeneID" id="13394080"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72479"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="F9XBU2"/>
    <dbReference type="OMA" id="RICRGMC"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="198"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="457"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="71208" checksum="62F0F490BE4F98FF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC73</accession>
    <name>F9XC73_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_109480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852643.1">
        <property type="nucleotide sequence ID" value="XM_003852595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC73"/>
    <dbReference type="FunCoup" id="F9XC73">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC73"/>
    <dbReference type="GeneID" id="13393957"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109480"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008917_4_1_1"/>
    <dbReference type="InParanoid" id="F9XC73"/>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="550" mass="61629" checksum="C148211CFA9579F6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCK3</accession>
    <name>F9XCK3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_109523</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852602.1">
        <property type="nucleotide sequence ID" value="XM_003852554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCK3"/>
    <dbReference type="FunCoup" id="F9XCK3">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCK3"/>
    <dbReference type="GeneID" id="13393992"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109523"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.427"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="F9XCK3"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="410" mass="45644" checksum="A485275BB7A23F71" modified="2011-10-19" version="1">MALQGMLNKLHGQPDSYDRKSKYRMGRTLGAGTYGIVKEADGPSGKVAVKIILKKNVKGNDQMVYDELEMLQTLKHPHIVKFVDWFESRDKYYIITQLATGGELFDRICEMGKFTEKNASQTIRQVLEAVDYLHSKDVVHRDLKPENLLYLTREANSDLVLADFGIAKHLDSPEGVLKTMAGSFGYAAPEVMLKKGHSKPVDMWSLGVITYTLLCGYSPFRSESLTDLIDETRNGRVVFHERYWKDVSKEAKAFILSLLKADPHGRATSSQALQDPWIAGKGATDHNLLPEIKAYIARARLKRGVELVKLANRIENLKMQEDDEEDAAQEADIPADSLRAADDASRHSHGASAEATGTPQEETDPSKKRSLSKLAKSAIFREVVLAKVRELKAEEEAQKTISEAAGKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD30</accession>
    <name>F9XD30_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_18344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD30"/>
    <dbReference type="FunCoup" id="F9XD30">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD30"/>
    <dbReference type="GeneID" id="13393664"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18344"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_3_2_1"/>
    <dbReference type="InParanoid" id="F9XD30"/>
    <dbReference type="OMA" id="IANTRYH"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15909" checksum="B1E0971057D4BC09" modified="2011-10-19" version="1" fragment="single">ILESTSKSTQFHKTQAQRDAERTYSAKDLSQQIPRRWKAGDVYAPHDLSGVEMSKWKKLRRKPRPKYDVLDQLGVNPLDHYKNFSIMSEYITPMGRIRHSNDTGLRPVNQRKMAKAIRRAMGMGLMPGVHRHPELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD66</accession>
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        <recommendedName>
            <fullName evidence="14">H+/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_43074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD66"/>
    <dbReference type="STRING" id="336722.F9XD66"/>
    <dbReference type="GeneID" id="13401439"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43074"/>
    <dbReference type="eggNOG" id="KOG3747">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="InParanoid" id="F9XD66"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64151" checksum="DE67354EC8311B2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDB3</accession>
    <name>F9XDB3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851854.1">
        <property type="nucleotide sequence ID" value="XM_003851806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDB3"/>
    <dbReference type="GeneID" id="13401546"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109847"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.326"/>
    <dbReference type="eggNOG" id="ENOG502QW50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045443_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDB3"/>
    <dbReference type="OMA" id="FMESLKW"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41990" checksum="77258AAA9ADF238C" modified="2011-10-19" version="1">MSNYGFFGSFELNSMVRGAQLTIVGANRALQNPSIFTTSLYKQAALAVAAGILIRLLVAIPTLGIRLLITFAGLFTDTSGLQWSEDIIDGIEFIEHSVLQIPFFLMSFMRYLSPAMDHMFMESLRWVDQTYVKKHESEDPKALREMYHPNLELYSQQAVTAQKKEPKQALVMFLTRYGRKAGISLAVYVLSFVPYVGRLVLPAASFYTFNKAVGLPPAIVVFGSSFILPKRYLVMFLQSYFSSRSLMRELLEPYFSRIHYSPEQKRAWFRDREGVLYGFAFAFFAFLKIPLIGVLIYGIAEASTAYLITKITQSPPPPQEAEEFKKRDVRWENKHEFLSLPVGALDRLSEKIVKEKGDKEQLKGRQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDE3</accession>
    <name>F9XDE3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1917-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851841.1">
        <property type="nucleotide sequence ID" value="XM_003851793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDE3"/>
    <dbReference type="GeneID" id="13402205"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43910"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051869_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDE3"/>
    <dbReference type="OMA" id="NISQEHD"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27366" checksum="614F4AB757779771" modified="2011-10-19" version="1" fragment="single">DENIQDFLHRLPVDDPKSAEVGHWLWVGSPTLSRAHAKRRKAEDTDAFGESAHALLEAFKAERGKVEGDNPGKAAATITKKMGPFRDALESDLLFLAVETGTTSGKWLLFPQPAQLKKVWAIVAAATAEGKLGPTSKVGTTSKVGEDSTVICVYTYDFSDFDDVRRVLRQVVELGLCYADGKPIFYKCDAYTYLHIKSDNIYKLRASLYNSTDVLHNDQEALDNGPVARMQKRKKPKMMDLAHHLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDI9</accession>
    <name>F9XDI9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_73191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851818.1">
        <property type="nucleotide sequence ID" value="XM_003851770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDI9"/>
    <dbReference type="GeneID" id="13402182"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73191"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.410"/>
    <dbReference type="eggNOG" id="ENOG502SJ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_1_1"/>
    <dbReference type="InParanoid" id="F9XDI9"/>
    <dbReference type="OMA" id="GFHTMRV"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="440" mass="48814" checksum="B743B3491AF23F55" modified="2011-10-19" version="1">MGSAGLPLQNRGIFRNLPTFDPSITGKTAIVTGANGISGFHTLRALLESSQRWTKVWAASRRPPPPEMMDLLPQSARSRVEHVACDFLSEPEDIAQQLREKGVTADAIFYYSYAQPKPKEGAPVWSNAEELTEMNCAMLRNFLASLDIAGVKPSRFLLQTGAKNYNVHQGPSRTPYVESDPRSNIEPNFYYPQEDLLFDYCKSHPETSWNIICPAWIIGATTNAAMNALHPIAIYAAVQAHKGQRMGYPGAYQNWLVTCEHSTAYLTGFLSEWAVLEQKCANQKFNASDTCPLPNNRLWPEVARWYGTTAPSQPELDDSKITTVTLPSGPSPLGYGPPVKPRFCFTLQGWAAEAENKQAWAEIMQKHNLSHNPFDDVTANFECGDFVVGALVSALSMNKARYFGWTGHVDTLESLFMAYSEMNKLGMLPPTVVDKANPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDU2</accession>
    <name>F9XDU2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_44207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDU2"/>
    <dbReference type="STRING" id="336722.F9XDU2"/>
    <dbReference type="GeneID" id="13401712"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44207"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010112_2_1_1"/>
    <dbReference type="InParanoid" id="F9XDU2"/>
    <dbReference type="OMA" id="WICTRRL"/>
    <dbReference type="OrthoDB" id="3645357at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="201" mass="22339" checksum="D97811ADC88D01CB" modified="2011-10-19" version="1" fragment="single">LLVNTPQVLISFVYLFYNNVVTGMLLAREYGNYASTRKPFRNTRPVGQQRTTTYWLQMPYRYLLPLMAGMALLHWLVSRSIFLVQIETYDASGSSKDTLVDTINACGYSVIFAISALVLGFALIVSLGCLSYRKLDPGIPVAGPCSLAISAACANVTEVYAARGPVQYGVLMNRKPDADGRQYLGFSGQDVEPLEWRKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDZ9</accession>
    <name>F9XDZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_100589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851610.1">
        <property type="nucleotide sequence ID" value="XM_003851562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDZ9"/>
    <dbReference type="FunCoup" id="F9XDZ9">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDZ9"/>
    <dbReference type="GeneID" id="13402029"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100589"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.580"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017019_1_1_1"/>
    <dbReference type="InParanoid" id="F9XDZ9"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000562">
        <property type="entry name" value="DNA damage-binding protein CMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="520" mass="57204" checksum="DEDFA4435780AFF9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEP2</accession>
    <name>F9XEP2_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851278.1">
        <property type="nucleotide sequence ID" value="XM_003851230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEP2"/>
    <dbReference type="STRING" id="336722.F9XEP2"/>
    <dbReference type="GeneID" id="13401110"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110078"/>
    <dbReference type="eggNOG" id="ENOG502SFBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323649_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEP2"/>
    <dbReference type="OMA" id="RCINRES"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="835" mass="93180" checksum="B945904CCEC01911" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEZ1</accession>
    <name>F9XEZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_100674</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850618.1">
        <property type="nucleotide sequence ID" value="XM_003850570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEZ1"/>
    <dbReference type="STRING" id="336722.F9XEZ1"/>
    <dbReference type="GeneID" id="13401084"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100674"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.141"/>
    <dbReference type="eggNOG" id="ENOG502QS47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="InParanoid" id="F9XEZ1"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP85594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="519" mass="58956" checksum="6943AD4B8D5BE541" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEZ6</accession>
    <name>F9XEZ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851250.1">
        <property type="nucleotide sequence ID" value="XM_003851202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEZ6"/>
    <dbReference type="GeneID" id="13395347"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94314"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.146"/>
    <dbReference type="HOGENOM" id="CLU_716122_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEZ6"/>
    <dbReference type="OrthoDB" id="10291382at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="43041" checksum="8FCA4632574BF73E" modified="2011-10-19" version="1">MATTEQPTDKPPEKSTDQASHRTNNSQHWLYAPLPSILQWWSQQNHSPQPTLLEIRLFLTRPTPPLPNHPPPPKHQTQLLLLLPTSTKTWSLPGRCFLATGPTRPPHILAAALSMLQHAIEERALLDLQFLDINHRLPYDPILTFLPDRPQPTLRCDLVLFTQKSTLDRDSIINASAHELETRSKPMFTAIRWTDTADLATLALHPEVTTSGIRHVFTRFTQFHKLHTDIRAKLDINSLITFVRFAILTKLSVWELDKGSPIFHALIAVDRRAPFAGLWVIDMGNVTHVKAPEGSEACIESMRAVPGGGLHVDYFLVVGQVREGKVWFAGEAGDLGPIRRLMGAVGGDGTMKVRWLQRTKMTKLGSVVKEANGSGLKRSADGVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF39</accession>
    <name>F9XF39_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850881.1">
        <property type="nucleotide sequence ID" value="XM_003850833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF39"/>
    <dbReference type="GeneID" id="13397619"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94767"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.735"/>
    <dbReference type="HOGENOM" id="CLU_1147974_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF39"/>
    <dbReference type="OrthoDB" id="10582139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="27047" checksum="B87FFF61B1A61039" modified="2011-10-19" version="1">MDTTKSSAAQRRHLTRTSTPLDAPMIDSWCDLPREMMEIIILEATTEAAMAPLRVTMTAYQPGQPRCIRAVDQKKWFAFVDAIRVTKSSRRMLLRNVHADGSLELVSLTGYRPKRLYHPSPALLAHFGLIWRSMGFRTPSIDNLDAGSPIDEACVGAQVKFFVPLPRPGQPQSVVRIEIVSSINPIPVLTNSEVRRKVAGWLRFASWGPWAFGIQRDPPLAAPLPVPATVNGMRALLRWVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFH3</accession>
    <name>F9XFH3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MgXYN1</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_94846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850952.1">
        <property type="nucleotide sequence ID" value="XM_003850904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFH3"/>
    <dbReference type="STRING" id="336722.F9XFH3"/>
    <dbReference type="GeneID" id="13397692"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94846"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.827"/>
    <dbReference type="eggNOG" id="ENOG502S0Y4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFH3"/>
    <dbReference type="OMA" id="HCHTLVW"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391361" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="67"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP85928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="370" mass="40608" checksum="B031FC1DFCB020DF" modified="2011-10-19" version="1">MLLTNTTAQHIDFIMLLTNSVLAALAMAGNAVATPHAPKPKGLWEAMQSRGRDWIGTAVTFRNDTVEASIYGNKADFNSITPENDMKWGLTEPQQNNFTLAGADKYADYARKHGVQIHCHNLVWHSQLPDWVANGNFTKAELTAVMKNHIDTLAGRYKDVCTRWDVVNEALEENGTYRNSVFYRVLGEDFLPIAFKLAHAASPKSKLFYNDYSLEGSDVKAAGAQRIVKYIQSKGGPIHGVGFQAHLTSEPTTSSGGGVAPGRVELTNRLQSFTALGVDVAYTELDVRMNTPATPAKTAVQAEVYYNVSSSCLATKRCVGMTLWGVSDKYSWIPGTFPGEGSADVWDENLQKKKTVYQRFLDGILCGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFI2</accession>
    <name>F9XFI2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850934.1">
        <property type="nucleotide sequence ID" value="XM_003850886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFI2"/>
    <dbReference type="GeneID" id="13397685"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110301"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.839"/>
    <dbReference type="eggNOG" id="ENOG502R8ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061837_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFI2"/>
    <dbReference type="OMA" id="ESKAGWW"/>
    <dbReference type="OrthoDB" id="5240110at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="289" mass="31081" checksum="BDAF81D620E55375" modified="2011-10-19" version="1">MSPSMSSTVLLRRTLTAATSTRSFSTTRRAPASLLFALGQLSNTRETQHFAKRSKLDHVEHSPPLQLIRSSEVDPFAPPKKVRATKAKDATAGTRAASIKEEFERNMAQSDGSGVAPLTGVRMNVDTSPCDAQLASVTQELTARLERSGRDIQDLEKGLAAVQKELGSLVKTLGIFMFLLVGGVTGVAMWNFWPQEKSGRTGEELGKKVAQRTRAARPLPAAGSLRRDVGIQTGLGATNAGLAEVMGEAAVLPVAASAVSAQPVAPGVQGVQSTQDEWRWYKNLFWKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFR4</accession>
    <name>F9XFR4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_60824</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850699.1">
        <property type="nucleotide sequence ID" value="XM_003850651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFR4"/>
    <dbReference type="FunCoup" id="F9XFR4">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFR4"/>
    <dbReference type="GeneID" id="13397437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_60824"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="F9XFR4"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP85675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="328" mass="36043" checksum="A6B6B32F4281A646" modified="2011-10-19" version="1">MLSRSAIRAARALGTGKSAGTKTVTRNASTQGSSESAASWKNTAMLSSSAALGFASVAWYYYQFGRPTQAMTPAEEGLHAIQYPWEHEKLTKTFDHGGLRRGFQVYREVCASCHSLSRIPYRTLVGNIMTVDEAKALAEENEYDTEPNDEGEIEKRPGKLSDYVPSPYKNDEAGRAANNGALPPDLSLIVKARHGGCNYIFSLLTGYPEEPPAGAVVQEGLNFNPYFPGTGIAMARVLYDGLVEYDDGTPATASQMAKDVVEFLNWAAEPEMDERKRMGWKVMAIGGLLFGMSVWVKRYKWSTVKTRKITYTAPPTNSPKQPGGVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGB2</accession>
    <name>F9XGB2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_74232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851063.1">
        <property type="nucleotide sequence ID" value="XM_003851015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGB2"/>
    <dbReference type="STRING" id="336722.F9XGB2"/>
    <dbReference type="GeneID" id="13397522"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74232"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_1_1_1"/>
    <dbReference type="InParanoid" id="F9XGB2"/>
    <dbReference type="OMA" id="TYWVPVY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="416" mass="46420" checksum="DA21C718704DDE2F" modified="2011-10-19" version="1">MEDLRFRPRLRAFLIASFVLFAATLTVISSRISHDTSSHRTLKFSKDGTFQIAVFSDLHFGENAWSTWGPRQDINSAEVMRNVLDAESQQLVVLNGDLITGENTFKSNSSNYVDRIVEPLLERDLLWASTYGNHDSAFNFSRAHIPAQERKHPNALTDRMVMDESAGISNYYLLVHPYDGCSIPSLVLWFFDSRGGHAYQERTASGRPIGLPNWVDASVVEWFISKNDMLVERYGRVIPALAFTHIPTNASRAFQTEVGVAAHLQPGIDDDNPLAQQAEGWCSDESDSGSCPYGGEDVPFMGAITSTPGLMAMFSGHDHGNTWCYRWDGMLPGMTVKGNGIHLCFGQHSGYGGYGSWARRARQIYVTQSSLREHSIESWIRLETGEVVGAVLLNSTYNIDWYSATQDTRTHCPTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGN0</accession>
    <name>F9XGN0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GHY</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_110289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851031.1">
        <property type="nucleotide sequence ID" value="XM_003850983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGN0"/>
    <dbReference type="STRING" id="336722.F9XGN0"/>
    <dbReference type="GeneID" id="13397553"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110289"/>
    <dbReference type="eggNOG" id="ENOG502QWG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_0_1"/>
    <dbReference type="InParanoid" id="F9XGN0"/>
    <dbReference type="OMA" id="MSQQFHR"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391647" description="alpha-galactosidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="6">
        <location>
            <begin position="665"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="812" mass="88944" checksum="7442B7AE64DCEFFF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGV5</accession>
    <name>F9XGV5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_87071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850470.1">
        <property type="nucleotide sequence ID" value="XM_003850422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGV5"/>
    <dbReference type="GeneID" id="13402740"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87071"/>
    <dbReference type="eggNOG" id="ENOG502QQY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGV5"/>
    <dbReference type="OMA" id="NNSHAGR"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000027">
        <property type="entry name" value="Arsenical resistance protein ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="9">
        <location>
            <begin position="90"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="36459" checksum="218E3BB1100661EC" modified="2011-10-19" version="1">MATTTNANHGDLNNTEVLRKTVALSPDPAYARTTLAIPEDKDDQSIRDQYRSYLLPHDVAANDWVSKLELSTALKMAEADMERTGGDRLKVMVLYGSMRSRSYSRLLAYECARILFRLGCDVRVYNPEGLPMKDDVQHNHEKVQELRELSKWSDGHIWISPEQHGNLTAVFKNQIDWIPLSTGSVRPTQGRTLAIAQVSGGSQSFNTVNSLRILGRWMRMFAIPNQSSVPKAYTQFTDAVDPADKEAFVKAEGGSRLMASGNRERLVDCMEEFVKYTIIMRQHFDLFNDRHSERMEKQAKAEKQKADEAKALCHSHASDAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGW2</accession>
    <name>F9XGW2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_46372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849949.1">
        <property type="nucleotide sequence ID" value="XM_003849901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGW2"/>
    <dbReference type="GeneID" id="13402743"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46372"/>
    <dbReference type="eggNOG" id="ENOG502RXUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1280466_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGW2"/>
    <dbReference type="OMA" id="DIGSAWW"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="6">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="22775" checksum="8D81811CC4B225F9" modified="2011-10-19" version="1" fragment="single">MPTAINGTTGPELPIQPRITPGLGVAGALLIITGVVLGFVGIKHRATQTFLSTALVTALGVVVLIIYLMNPPVTDAIEGAFLIAAVLGGCLLGGMALIFKEVSEGLGCILGGFSLAMWLLVLAPGGTIHNQVGRIVLICMLCAAGFCLYISRFTRVYGIIGCTAFAGATAFILGVDCYSKAGLKEFWIYIWNINDDVFPLFTNTYPITKNMRAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHS4</accession>
    <name>F9XHS4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_16314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849868.1">
        <property type="nucleotide sequence ID" value="XM_003849820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHS4"/>
    <dbReference type="STRING" id="336722.F9XHS4"/>
    <dbReference type="GeneID" id="13402661"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_16314"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253327_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHS4"/>
    <dbReference type="OMA" id="WDARIGM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="221" mass="24330" checksum="C9B8EE5351722775" modified="2011-10-19" version="1" fragment="single">DQNISSITLDDGKVITCDLIVAEDGSGSQIRQALFPQHHGRKVLNKTVWQISLPLDVVRKDDSLRGLLDEHHNVIILAPGRSIIASPSPSQNIHDLQLIDHEHTLEQDSNPTALNERVFDLEGVKSRFSDFDAATRKVIESVESAFKWRLVEVFDLPSWSSDDGKVVILGDAAHAMTPYSGQGTAMGIEDAAALSELLANASSGSDLRLLTENYENLRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ34</accession>
    <name>F9XJ34_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849304.1">
        <property type="nucleotide sequence ID" value="XM_003849256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ34"/>
    <dbReference type="GeneID" id="13398925"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105659"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.107"/>
    <dbReference type="HOGENOM" id="CLU_1483137_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ34"/>
    <dbReference type="OrthoDB" id="10441701at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390668" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="182" mass="20241" checksum="44C05B7E0AAAD025" modified="2011-10-19" version="1">MLSSLLSLLALSASLISAEESIPYKLKTESDSTFLYITPIDDCKYKVSATGYSGAGSKFHWTDTQNINNSTIVATDYGPNALLDVYAVRRPESLGMAQVFVRTNISEEERTFTQQISIADSQLRYGGYEGVPYVFFFCNTEVTDDFVDLPHTLFIRRSDICLPEGCWDTVLDLTSQGLRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ56</accession>
    <name>F9XJ56_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849314.1">
        <property type="nucleotide sequence ID" value="XM_003849266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ56"/>
    <dbReference type="STRING" id="336722.F9XJ56"/>
    <dbReference type="MEROPS" id="C85.003"/>
    <dbReference type="GeneID" id="13398935"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95583"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.130"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048473_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ56"/>
    <dbReference type="OMA" id="AHIAYHT"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="445" mass="49403" checksum="5DFD637BB5E44521" modified="2011-10-19" version="1">MGGSTDEFPLLSALGLYAADIRGDGNCLFNALSDQLYGHQNEHANIRSRVISYMREHADYYKQFIDVNPGGGIRRNPKRKGVNVNTCTSYSNFSAPTQADIDRVFDSHLESMARGGTYGDNMEITAFSSAFDCDVKIYQRDFAYVVSGGEDRDRPVAHIAYHVWEHYSSIRNLEGPHTDLPNVSPKVLSPQEEQIQKEKLAQVPHVQPWQIDVVSKSLPFLADKPTIKRALEAAKGKIDIAVSNLLDAEENGSNSSSHQESSSIERDLDSDDDHDVPNKKKQDRRMSRAARALKELEPYNKPPIPKSFAVQDRSQESFSSWESEASSTNPAPSSQASTTSTSASSTTLMPDTTSTSSPTKKPTVRLKLLPPRPPPKKEERVTARDKKDFKKQAQKAARKERQLADAHQEHGKAKSGVHLTLRAKDDSGTRVNGTPPVETLRTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKB3</accession>
    <name>F9XKB3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_101221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849697.1">
        <property type="nucleotide sequence ID" value="XM_003849649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKB3"/>
    <dbReference type="FunCoup" id="F9XKB3">
        <property type="interactions" value="1307"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKB3"/>
    <dbReference type="GeneID" id="13399104"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101221"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.330"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKB3"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="343" mass="38137" checksum="1A22AEF5EE7B02C1" modified="2011-10-19" version="1">MPPKKGATNEPKKAKPSVADKTFGMKNKKGGAAQKQIQQIAASTASAKGPEAKKKEAEKLAREKEKAAAEAAAKEVADLFKPVQTQKIPFGVDPKTILCQFYKKGHCDKGRKCKFSHDLNVERKQEKKNLYTDMREGDEEGEEDGKKKDDMADWDEEKLRQVVMSKHGNPKTTTDKVCKFFIEAVENGKYGWFWICPNGGDKCMYKHSLPPGFVLKTKEQRAAEKALMDKSPLNTLTLEDFLESERHKLSGTLTPVTPETFAKWKKERLDKKAAEAQAQAMKEATGRALFEKGDWQGSDSEAESDDDDDDDGGFNLDALRRETEAAREEKEAERLAALGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKK5</accession>
    <name>F9XKK5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_62800</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848747.1">
        <property type="nucleotide sequence ID" value="XM_003848699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKK5"/>
    <dbReference type="GeneID" id="13396581"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62800"/>
    <dbReference type="eggNOG" id="KOG2966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035826_1_1_1"/>
    <dbReference type="InParanoid" id="F9XKK5"/>
    <dbReference type="OMA" id="IKHECDA"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="316"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="459" mass="52421" checksum="109F290BBA51B08B" modified="2011-10-19" version="1">MEPLLSRLAIQAAPRIPRSSFTLRPHRPTLSLSSRTPRLFSTTIPRLLPKERKIYDTKSAPDSSFSRPAAELSHNVTQDEKDHFSRVESESKQMQARSPWTREGSDVPPVHRPRSAGAMTKGKLLTTPSRMLKLVLPLTTRDKNEDRKDVEPLALLVHPQQPLSYLERLIQSELPFFWDEKKGRERPPDVVFRAEDSMEDETGNDVEDVVVVEEETVDDNADETMVDGKREKTGKISGGGGDKKEVVRKKREDQVEKDERTAKDPDHANFVRWSPSTEIGDFIRDAARGKEFAVEVEGAPEPIYVGVPSFSDRTYYLRMRLRKISKRISNMADVKQECDELAHRGAKQVARLGFGGLLGWWGAVYYCTFLTDLGWDVMEPNTLYKAKGFDLASWEMLIEEGNRLRREVKLVAEEYDVEWDEMKDEGEEKVRKALQSERKKAAGGKDKAKEKDDDDEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKU3</accession>
    <name>F9XKU3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MgNTC2</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_48841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848985.1">
        <property type="nucleotide sequence ID" value="XM_003848937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKU3"/>
    <dbReference type="STRING" id="336722.F9XKU3"/>
    <dbReference type="GeneID" id="13398337"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48841"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.518"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="InParanoid" id="F9XKU3"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391730" description="Trehalase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="637" mass="70534" checksum="BD36B1E1FF1487F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM73</accession>
    <name>F9XM73_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848460.1">
        <property type="nucleotide sequence ID" value="XM_003848412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM73"/>
    <dbReference type="GeneID" id="13396192"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106227"/>
    <dbReference type="HOGENOM" id="CLU_3108213_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM73"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="51" mass="5697" checksum="DA1200E757225F8E" modified="2011-10-19" version="1">MLFSSLLRLKSENQTGLVVAGFINDMAQKVRTTTDMIRFSTRSCLLSASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMF2</accession>
    <name>F9XMF2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_96451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848735.1">
        <property type="nucleotide sequence ID" value="XM_003848687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMF2"/>
    <dbReference type="GeneID" id="13396354"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96451"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.18"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9XMF2"/>
    <dbReference type="OMA" id="YIENDIG"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="509" mass="55888" checksum="7BB7F7498050D015" modified="2011-10-19" version="1">MSAKSTAVDHVTKTSSDYEDGHAAQGEFSSVISDEDRFGFSEKQKKSIIRRIDLRVVGLLGAMYATSSVDNATIGLVLIAGMGADMKLNSTQYSTITSMFYVTFLLFQLPAAVILRKVGPKKFLCTITILWGLTTLACGFVRNWYDLVALRLVLGVWEAGMFPAVTYFLSLWYPRYSMQKRYALWLMLGIIPAAFSGIVCYGISHLAGKGVGPKAWSQNQTGDGIAGWRYIYWIFGACTLCVGIFSFFFIVDFPEKLALGTSKTKRPFLSQEEAAWAVSRVEADRHDVMPPEFRVWEYLGHLKDAKLWAMALCYGCNTVALHGVGFALPYILSEGMGYGVGEAMALSTPPTLLGSITMVFAAYFADRFRRRTPFILVGACMVIVGLSLIGFVEIVGLRYFGVFLSLCGGLSNTPAILAWQANNIRGQWKRGLSTALLSIFASLAGLVGSFVFRAQDKPHYYPGIITCIGAQTIMIIIVLSLNVVFKRANKKAAATGIPIEGLEGFRYTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMW6</accession>
    <name>T4HR_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tetrahydroxynaphthalene reductase MYCGRDRAFT_87994</fullName>
            <ecNumber evidence="3">1.1.1.252</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Conidial pigment biosynthesis cluster 29 protein MYCGRDRAFT_87994</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">MYCGRDRAFT_87994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="631" last="631">
            <title>In silico prediction and characterization of secondary metabolite biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.</title>
            <authorList>
                <person name="Cairns T."/>
                <person name="Meyer V."/>
            </authorList>
            <dbReference type="PubMed" id="28818040"/>
            <dbReference type="DOI" id="10.1186/s12864-017-3969-y"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Probable tetrahydroxynaphthalene reductase; part of the gene cluster 29 that mediates the biosynthesis dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:28818040). Catalyzes the NADPH-dependent reduction of 1,3,6,8-tetrahydroxynaphthalene (T4HN) into (+)-scytalone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>scytalone + NADP(+) = naphthalene-1,3,6,8-tetrol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21908"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16945"/>
            <dbReference type="ChEBI" id="CHEBI:18365"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.252"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:21910"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Pigment biosynthesis; melanin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.252" evidence="3"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848335.1">
        <property type="nucleotide sequence ID" value="XM_003848287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMW6"/>
    <dbReference type="SMR" id="F9XMW6"/>
    <dbReference type="EnsemblFungi" id="Mycgr3T87994">
        <property type="protein sequence ID" value="Mycgr3P87994"/>
        <property type="gene ID" value="Mycgr3G87994"/>
    </dbReference>
    <dbReference type="GeneID" id="13396131"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87994"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="F9XMW6"/>
    <dbReference type="OMA" id="EYACTWS"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="UniPathway" id="UPA00785"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047039">
        <property type="term" value="F:tetrahydroxynaphthalene reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0470">Melanin biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000451091" description="Probable tetrahydroxynaphthalene reductase MYCGRDRAFT_87994">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q12634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="267" mass="28465" checksum="661F2735877984B9" modified="2011-10-19" version="1">MAVTPYVDTSRLDGKVALVTGSGRGIGAAMAIHLANRGAKVVVNYANSVEAANKVVDEIKSRGGEAIALQADVGEVSQTTKLMDDAVAHFGQLDIVCSNSGVVSFGHLKDVTEEEYDRVFRINTRGQFFVAREAYKHLSVGGRIIMMGSITGQAKGVPKHAVYSASKGAIETFVRCMAIDCGDKKITVNAVAPGGIKTDMYHAVCKEYIPNGENLTDEEVDEYAKTWSPMDRVGQPMDIAKVVGFLASEDGEWINGKVIGIDGAACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN36</accession>
    <name>F9XN36_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_49627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848607.1">
        <property type="nucleotide sequence ID" value="XM_003848559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN36"/>
    <dbReference type="GeneID" id="13396401"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49627"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="F9XN36"/>
    <dbReference type="OMA" id="HARRYCS"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37199" checksum="76857319DA9F7B3C" modified="2011-10-19" version="1">MPDLPGTSGSNNAESSPENPPAAPRRSLVTIHETHPLVLEKDKSIIPEHGVIHYPFYYGGLASCVSVCCTQPMGVGQSRPLRLRPYDTDEQQLVYLRLQTHDHSVARLGMMRIFGQLGASLTRTVIYSGLRFGIYEKLKELSTTPTHTPTAPAMAGLAAISGIAGSLSSNFADIVCLRMQNDLGLPIDQRRNYKNIGHGVVKMIRTEGWRSIWTGAGVGAGRAAVGTATQLAGYDIFKRELLKRTTLGDDIPVHITASCLAGFLSTLLCSPLDVFKARIMTQKKGGSIPGMIKLMFKTEGPLWMYRGLTPALISRGPSTIITFVAFEQLKKAYRRTHGFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNJ6</accession>
    <name>F9XNJ6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_64146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848178.1">
        <property type="nucleotide sequence ID" value="XM_003848130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNJ6"/>
    <dbReference type="GeneID" id="13401520"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64146"/>
    <dbReference type="eggNOG" id="ENOG502S8X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_4_1"/>
    <dbReference type="InParanoid" id="F9XNJ6"/>
    <dbReference type="OMA" id="RFFVYAP"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="90" mass="9900" checksum="CFEBF663D439AE66" modified="2011-10-19" version="1" fragment="single">MGKQEWLVIIKDKPNSLPARMKVRPQHLEELKPHIDSGAIVLGGATLDEPLKEGEGMKSNGSVLIIEAESEKEARGIVEGDVYYTSGVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNW1</accession>
    <name>F9XNW1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_50623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848122.1">
        <property type="nucleotide sequence ID" value="XM_003848074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNW1"/>
    <dbReference type="FunCoup" id="F9XNW1">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNW1"/>
    <dbReference type="GeneID" id="13401938"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50623"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.268"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="InParanoid" id="F9XNW1"/>
    <dbReference type="OMA" id="TTFTRNK"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="55"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="407" mass="45253" checksum="76903DA77C456BBF" modified="2011-10-19" version="1">MIFFHSLLREAAPLVKGPYKLPLERLSWPVQCYASISRDPYLNLAIEHYLLQKSHPDSAILFTYTNRPSIVIGRNQNPWLEVNLALLGDRRPPPKVKPGPKPKPKGLGAVDLVRRRSGGGTVFHDEGNMNWTVITPSATFTRDKSAEMVVRALRLCKIDRARVNARHDIVLDQGERGADTDPADTHSTPYEAKDFDTPRPLKVSGSAYKLTKGRALHHGTCLLSSPNLDVIPDYLHSPAKPFMTARGVESVSSPVGNIKLKAWRFGAAMMQHFAEQYNDNKTVPAITVSSRWLENEDVRKGYEELKSLEWTYLQTPQFTISTESVKDLNANLELSVRNGVVNGVSLSYKASGTSSTSQDDLDGLIGCKIHEIEHWGAVMDRALSGMDSAEKSSVVAWLNKMLPKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP52</accession>
    <name>F9XP52_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_64379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848013.1">
        <property type="nucleotide sequence ID" value="XM_003847965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP52"/>
    <dbReference type="FunCoup" id="F9XP52">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP52"/>
    <dbReference type="GeneID" id="13402092"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64379"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="InParanoid" id="F9XP52"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="190"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="460" mass="49849" checksum="16EA8B494C64B346" modified="2011-10-19" version="1">MSNLPSEPEFEQAYKELASTLENSTLFEKNPEYKKALEVSAIPERVIQFRVTWENDKGECQVNRGYRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGADFDPKGKSDNEIRKFCVAFMRELNKHIGADTDVPAGDIGVSPREIGWMFGAYRAEKNKWEGVLTGKGGNWGGSLIRPEATGYGLVYYVQHMIQYASSGKQSFQGKRVAISGSGNVAQYAALKAIELGATIVSLSDSKGAIIAKGDAGITPEVVNYIAALKVKRKSLTELSESAEYKDKFEYIDGARPWVHVGQVDVALPCATQNEISGEEAQALVDAGCRFTAEGSNMGSTQEAIDVFEKVRKEKKAEGIWYGPGKAANAGGVAVSGLEMAQNSARLKWTSEEVDEKLKGIMEACFQNCLETAKEFVPVGEDGELPSLVAGANIAGFSKVAQAMRDQGDWWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPR6</accession>
    <name>F9XPR6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_51298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847755.1"/>
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    <dbReference type="AlphaFoldDB" id="F9XPR6"/>
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    <dbReference type="eggNOG" id="ENOG502SH4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044247_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPR6"/>
    <dbReference type="OMA" id="FWDGGVS"/>
    <dbReference type="OrthoDB" id="2853639at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="373" mass="42128" checksum="ABA01C16675F9386" modified="2011-10-19" version="1">MTASPILNLPEDILVLLPNYLDNIEDYTNFSSTCRDLRRVLSNPHPNTILHLAAAQSRIFFRPSPIFLATATARELGHWARLSPANEALLATACRNGAEGLLDLALQHVGLTLPRIRQLHALRFSVINPVVDLIDKCVGDQWYATPDFWDGGASDAYTIDSEPGHTFFHLAMYGELFGPDIETLLNRDSSKRRLSVDTRLEFVKYCIPEPYTGMITSTTSPGLHQIIDPRRRVELVGPYAKGDKGSHPDYPKQNNLALTWTIRSRKFNAPLKALRHAAGSDFQANFDDGCGEKRNWRQRMWENMLVCQGLDGLGMLREDLRDEWVETVRSWRERIAAMEKEPEVVIIGRQGTMEYPFLLGDLRSCMSGYVPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQJ1</accession>
    <name>F9XQJ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP82370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847394.1">
        <property type="nucleotide sequence ID" value="XM_003847346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQJ1"/>
    <dbReference type="GeneID" id="13400543"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106576"/>
    <dbReference type="HOGENOM" id="CLU_2456508_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQJ1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395736" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9492" checksum="2540DB1528A14287" modified="2011-10-19" version="1">MMRMAIWVSNLMLSFAGLLAGGYGTAGSRLPVALVHGSSRPRFPATPQKHTHTTLASIFDVSALVRHLPSAPFKPQLSGNNSSPNVCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847120.1">
        <property type="nucleotide sequence ID" value="XM_003847072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRN7"/>
    <dbReference type="GeneID" id="13399443"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111771"/>
    <dbReference type="HOGENOM" id="CLU_534436_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRN7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="510" mass="56329" checksum="9A582CB25BB9B7FE" modified="2011-10-19" version="1">MTTHEQLAADKLAPRLRGLSRDEIEKCHYEVPKGIKLRLTLPSIAGSASIPSKGANVFEIISRGKIRELGLVAVFEMVSSTAIALRLYIALLRDRMQHCFQGGLCSGQFMDSQRFDVSYLNVRRDHEVAFRKFILAFSYYAMLSSTPSSLQFAIGNESFSAVRMGAVLKIQICPNCSQICPNMPEAHQYLNRVDFRGEAPPSGGTFQVAVDPFSVLPLLRHLHRSIFSANISTPPKSSTRRSLQPADVSTPPTHPPRRYVHILDPPLQCPLTTPPPRILHSSNPPTPPPPRLLVRCSAETATPCEMQPPGATRTGTTDYDDGHGNAYEEDERGHERGGDEDGSGGERGQEWYFSARTFTAIEFGTQHSTLQRQEDGRHLPPSSARRLASKHKSIIPKLGESTANVLQKRQLFVASRDGEAPPYWRAGPRRAVSRRSVGRLLVGLVAANEAGSGACRWLEEPSARSLRTRTGRIKAIVFLPQVYAMLHSNPGGAYLRPPKHAAPTKRRPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRY6</accession>
    <name>F9XRY6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847025.1">
        <property type="nucleotide sequence ID" value="XM_003846977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRY6"/>
    <dbReference type="GeneID" id="13399420"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97979"/>
    <dbReference type="HOGENOM" id="CLU_386467_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRY6"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="715" mass="78083" checksum="FEDF570E960BC4AA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS79</accession>
    <name>F9XS79_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_83270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP81918.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="53" mass="5582" checksum="304BFB15D188D850" modified="2011-10-19" version="1" fragment="single">MPKAYSHAKDPVVDVATDPPISSTESEASFVTATLLPDIRTSPLPLLLFGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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            <taxon>Zymoseptoria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP81877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS96"/>
    <dbReference type="GeneID" id="13396648"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98086"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_21.23"/>
    <dbReference type="HOGENOM" id="CLU_1653535_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS96"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17721" checksum="191C705F4EF53246" modified="2011-10-19" version="1">MDDRWGTWLAGTPAQLLRDKIVPSGHRRIFIGPSGESFSQCGHDVEDIPVPIAACLTYDPSTEGGAQYSVAHIAFTTAQQIGRRPIWMCLPDEAPDSATLRIIGSILLALEIPVHFCVHGPGRELHRMDIFKLKDFDNETTKALRKAFDDKTNQAPRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSD0</accession>
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        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98120</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003846829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSD0"/>
    <dbReference type="GeneID" id="13396670"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98120"/>
    <dbReference type="eggNOG" id="ENOG502S6DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334064_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSD0"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="753"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="96005" checksum="427EC541D5B117FA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWF0</accession>
    <name>F9WWF0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CYP-64</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_65881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9WWF0"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65881"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="F9WWF0"/>
    <dbReference type="OMA" id="MEQSTHI"/>
    <dbReference type="OrthoDB" id="3644172at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="498" mass="56160" checksum="30CF9A58C81FE964" modified="2011-10-19" version="1">MLDWMSVAPSGLSAFAGTVLLALIYSATTVGYNLYLHPLAKYPGPKVRAASGWPYFLDLIRGNSPQYMLELHDQYGPVVRVAPNELIFNRPQAFKDIYGRKAGQKELRKDEMYASGMGEPTLLYCDETYHSYIRKLMAPGFSESALRKQETVVQSRLALLICKLHEEGQDGHASIDLMKWVNFFIFDVVGHLTYGDSFECITSSALHPWITKFTGLGRPMAYAQASQRLPRFLRLPFLALMLDRSLLSDRKFLYKTSEKAKVQARIAKESPIPDFMGTLIESHKDGKMTALQLNSNAVFLMAAGTETLVTSVVHTIFRLLTNKHALLKLTQEIRSTFTTSEDITMTGVNKCRYLLACLDESLRIQAPSPVTHPRFTPTEGITIDGHFVPGNMAVGVPIHAACRSSVNFHDPDTYAPERWTGEDRRYINDSKDAAMIFSVGPRDCLGRSIAMIGLKLVIARLIWHFDIEQCFPDDWAEQKVYLVWEKSPLMVKLHPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWQ5</accession>
    <name>F9WWQ5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_33699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856490.1">
        <property type="nucleotide sequence ID" value="XM_003856442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13399116"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33699"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1382"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_20_2_1"/>
    <dbReference type="InParanoid" id="F9WWQ5"/>
    <dbReference type="OMA" id="IDRGAKC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1523"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="622"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="766"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP91466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1636" mass="182535" checksum="260F5346086BF9EB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWR9</accession>
    <name>F9WWR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_53663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857170.1">
        <property type="nucleotide sequence ID" value="XM_003857122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWR9"/>
    <dbReference type="STRING" id="336722.F9WWR9"/>
    <dbReference type="GeneID" id="13399033"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53663"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1398"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWR9"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="246"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="711" mass="80018" checksum="78634CC6B9E123C1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWW0</accession>
    <name>F9WWW0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MgBMN2</name>
        <name evidence="21" type="ORF">MYCGRDRAFT_107565</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857077.1">
        <property type="nucleotide sequence ID" value="XM_003857029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWW0"/>
    <dbReference type="STRING" id="336722.F9WWW0"/>
    <dbReference type="GeneID" id="13398864"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107565"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1605"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_0_1"/>
    <dbReference type="InParanoid" id="F9WWW0"/>
    <dbReference type="OMA" id="SISYMPC"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001511">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395174" description="Beta-mannosidase A" evidence="16">
        <location>
            <begin position="22"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="20">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="20">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="17">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="19">
        <location>
            <begin position="691"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="18">
        <location>
            <begin position="796"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP92053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="881" mass="99500" checksum="C53B717113757108" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWX1</accession>
    <name>F9WWX1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_107571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857071.1">
        <property type="nucleotide sequence ID" value="XM_003857023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWX1"/>
    <dbReference type="STRING" id="336722.F9WWX1"/>
    <dbReference type="GeneID" id="13398858"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107571"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1617"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005100_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWX1"/>
    <dbReference type="OMA" id="WPTPQVA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="708"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1169" mass="127009" checksum="376955CEC3DE1CA6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX44</accession>
    <name>F9WX44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_84213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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    <dbReference type="STRING" id="336722.F9WX44"/>
    <dbReference type="GeneID" id="13398694"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84213"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1832"/>
    <dbReference type="eggNOG" id="KOG1176">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="F9WX44"/>
    <dbReference type="OMA" id="GLMQDWP"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91681.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60808" checksum="EE78991C700158EA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX64</accession>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX64"/>
    <dbReference type="STRING" id="336722.F9WX64"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67546"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2014"/>
    <dbReference type="eggNOG" id="ENOG502SHVE">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="226" mass="25832" checksum="20EF5A3CB82DF291" modified="2011-10-19" version="1">MPYESTINFTLDTICPWTYLAKRRLAKALAQIPQDTTSTTFTVKYLPYQLYPSASQTGEDKYAWYKKSRYGDSAEKMKVYETLMTAYGIGEGIDYKFTGTVANTIHAHRCIYVFQEKYGPEVVDKFVDSLYRQFFEEEKHPSSHDTLLAAAREAGIEDGEARRVIVEDEDEGLMDTKMLIREQAGNAIDSVPYIVIDGKRRDVTLQGCREVPEYVKALEQVVKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXD0</accession>
    <name>F9WXD0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_26212</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857753.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13403805"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26212"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXD0"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR039121">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="326" mass="36313" checksum="3AD4E2D4920FA546" modified="2011-10-19" version="1" fragment="single">PSIPRPSASVLVISPNNQILLLQRVRQSSSFPSAHVFPGGNVSTFHDGDAPPPDHPGRHVDSEVYRLAAIRETFEESGILLARNNGFGRLIEVPEEEREEGRKAVHGNQVPFTQWLSQKGGRADLDGLLPFTRWVTPTNVPKRFTTQMYLYFLPTQSTTPLGAEGKEQEEEEVRIPVPTTDGGLEHTTARFLPASAWCRLAQEGRIILFPPQFYLLHQIAQHFDDLKAPTDYASISKEAVPREELENRRKALVEFVKSGSPPWTEKCISPIVQPPRDGKPREDGRAVLGLNRPGPELENAGLERSGVREECVLVDFQKGGPRRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXE5</accession>
    <name>F9WXE5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HMG1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_64888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855796.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9WXE5"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_64888"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="271"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="249"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    <sequence length="1144" mass="122739" checksum="C21A9F545D46311F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="163" mass="18904" checksum="496CCF43CA87D1E3" modified="2011-10-19" version="1">MCQYYHWRCGVCLTDNEIARRCGRMRERCAKNGDLLPLPPDAEGISCQWCRRPRFVDQKQAPPRFRHAVKPIQSTSKCPVKTEAQWRVPAENDAFWLRPSTRLPDAAEKMAQYNHQRHLVFKASDQAIGLKQDSREGTNTGSNGQSFLYDEAWRKLKERLQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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    <name>F9WXW4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856123.1">
        <property type="nucleotide sequence ID" value="XM_003856075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXW4"/>
    <dbReference type="GeneID" id="13403096"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78344"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.629"/>
    <dbReference type="HOGENOM" id="CLU_155628_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXW4"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="104" mass="10736" checksum="FBA55B8029ED305B" modified="2011-10-19" version="1">MPGRACGSGIASSLVGLTRGLAIDLAPLRVNLILPGAVNTELWDHLPAEQKQGSVDSFGKSMLTGKVPGPEVIAESYLYAMKDANLTGVCLSTNGGQLLAWPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY29</accession>
    <name>F9WY29_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_98569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857288.1">
        <property type="nucleotide sequence ID" value="XM_003857240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY29"/>
    <dbReference type="STRING" id="336722.F9WY29"/>
    <dbReference type="GeneID" id="13394940"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98569"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_1_1"/>
    <dbReference type="InParanoid" id="F9WY29"/>
    <dbReference type="OMA" id="WIDFFIP"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="283" mass="31295" checksum="E8BB21BE98870954" modified="2011-10-19" version="1">MLKCCPRPVVRTLGTRAVFAQRKMATIRSSVPHEDRTAAEPREGQLEAVVLANIKEVNDNVRLLRLFPVINRTIKFLPGQWLDTFIPGIPRAGGFTLTSTPDQARASVSTPPYLELAIQKSRNPPAQWLWKPSEEIIGTQLVVRVGGSFTWPPPHLDVAKVDRLVLVAGGVGIKILFLPRLMDLVAAAADSNVTLRLFLTGTGDQGYIEHGKLPNSTFGGRIQEIDLLKAIDGYKKNVFGPEHDRKGTVALVCGPPKMTDEMVAYLQKQPGMSLDRVLCEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYH1</accession>
    <name>F9WYH1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857033.1">
        <property type="nucleotide sequence ID" value="XM_003856985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYH1"/>
    <dbReference type="FunCoup" id="F9WYH1">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="13398054"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28532"/>
    <dbReference type="eggNOG" id="ENOG502SERM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085810_0_1_1"/>
    <dbReference type="InParanoid" id="F9WYH1"/>
    <dbReference type="OMA" id="RIGHYQR"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="152" mass="16961" checksum="4ECDA6E9FF755FC6" modified="2011-10-19" version="1" fragment="single">KQLDVEALLSKPTWSVASLLPSDTAATETPKVSSTQLHHLLRLSALPPPTSPVEETAMLQTLTSQLHFVKQVQSVDTTNVEPLRSLRDETEEGEKEAELGLEALKGALAKEEVRGKFHKRIRRKREVQDAEKWDVLGHAERKTGRYFVVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYL0</accession>
    <name>F9WYL0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_67342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856960.1">
        <property type="nucleotide sequence ID" value="XM_003856912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYL0"/>
    <dbReference type="STRING" id="336722.F9WYL0"/>
    <dbReference type="GeneID" id="13398671"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67342"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="F9WYL0"/>
    <dbReference type="OMA" id="CWDDKET"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="360" mass="38392" checksum="F0F59B9A91613F5B" modified="2011-10-19" version="1">MAEIEIPKQGLAGVCVNEGPDFRVEVQMVDVPEPKDGELLLRLNATGLCMSDVHFMMNDWAVPPMSTFGTKCAGHEGAGVVVKVGNNVQGWKVGDRAGIKPLWDVCHNCEECFTGRDNYCQKGVYTGLVAEGSYRQYVTSPAIYTSRIPDGVPDEVAGPIMCSASTMHRALIDSGLKAGNWVVFPGGGGGVGIQGVQLAKAMGMRPIVIDSGEAKKELCMKLGAEEFVDFKEHADVAARVKEVAGGIGAHGVLVTAYQAYKDAIPFIGDRIGGRIMCIALPPAGEINIGADPSHFAFKNLHIIGSLVGTMQDTAATLDYARRGLLQGVAEVRGISRFNESVQALRRGEVAGRIVIDFNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYL6</accession>
    <name>F9WYL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_54282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856956.1">
        <property type="nucleotide sequence ID" value="XM_003856908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYL6"/>
    <dbReference type="FunCoup" id="F9WYL6">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYL6"/>
    <dbReference type="GeneID" id="13398206"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54282"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="InParanoid" id="F9WYL6"/>
    <dbReference type="OMA" id="GLMFFTR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="215" mass="24016" checksum="039CB9935E77FB18" modified="2011-10-19" version="1">MASSSFRDSMNNLGWSRREEPANTTSQTSLLGSIQKYNPFSNEGNVRLPTHEGEGPGAPLPARTRREEEEGWFALSRWDRLLLFGGLNLAAIALFVVCFTLLPVLSLRPRKFAILWTMASVLFLSSWAVMMGPIIYVRHLISQERLPFTATYLGSIVLTLYFAMGLKSTVLTLFSSIVQMVALVWYLVSYFPMGSTGLRFAANFGISRVTGWMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYN0</accession>
    <name>F9WYN0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_31720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856732.1">
        <property type="nucleotide sequence ID" value="XM_003856684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYN0"/>
    <dbReference type="STRING" id="336722.F9WYN0"/>
    <dbReference type="GeneID" id="13398214"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31720"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1895"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="InParanoid" id="F9WYN0"/>
    <dbReference type="OMA" id="YTTMAVR"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="278"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49948" checksum="3C8A1E0DE8B5A4E7" modified="2011-10-19" version="1">MPSAPPIPTNTTRVAIPPSVPFAEPPWAQGLPSYWLTPELKQYQQRLRAFISENLTQHAWEWDKEETVPAHVFDTFAKANMLVPALPAPLPVKELHAAGIHEVMGVKVEDFTAWHNYLYGDEMIRSGLTGPGGSLTTGMAFGVPPIIKFGNEQLKQRFLPDLLTGRKRTCIAITEPDAGSDVANIRTTAVKSKDEKHYIINGTKKWITNGIWSDTAAMAVRTGGPGPGGLSMIVVPLKGQKGVDMRRLKVSGQVSAGTTFIELDDVEVPVENLIGEEGQGMRYIMTNFNHERMSIAIGVTRQSRVVLSAAFEYVLKREAFGKTLFEQPVVRHRLAKAGALVESLSAWVEQFVYQLTIMKKEDADVELGGLTAGVKAHAGMVMKECADCAVLLFGGNGYTRTGQGEIAERMWREVNGNRVPGGSEDVMLDLMVRQLGKNFQRKTALLEKCQKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYR0</accession>
    <name>F9WYR0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_33636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855919.1">
        <property type="nucleotide sequence ID" value="XM_003855871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYR0"/>
    <dbReference type="STRING" id="336722.F9WYR0"/>
    <dbReference type="GeneID" id="13403298"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33636"/>
    <dbReference type="eggNOG" id="ENOG502SFZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157438_2_1_1"/>
    <dbReference type="InParanoid" id="F9WYR0"/>
    <dbReference type="OMA" id="GSADKMQ"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="69" mass="7492" checksum="8A55DA43F1D3F9FD" modified="2011-10-19" version="1" fragment="single">QRKQTGNRVIKPKKAALIKQNTMKKKHSSGLSTLTEKTLATKAGHLELLRGGKKDRQAAEAAKAAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY7</accession>
    <name>F9WYY7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857611.1">
        <property type="nucleotide sequence ID" value="XM_003857563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYY7"/>
    <dbReference type="GeneID" id="13403182"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102147"/>
    <dbReference type="eggNOG" id="ENOG502S606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975077_0_0_1"/>
    <dbReference type="InParanoid" id="F9WYY7"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="286" mass="30068" checksum="926919EED85B8007" modified="2011-10-19" version="1" fragment="single">MDARIEGTAVPQIEAVSPLAQPNPSSKQHQQQPELRPNVRSMPGSPSRLPHSAIGVSPSRLRSSSPRHSPGTSEIFERNVQEPVAISNLQGDFDQTHIPAHVITEDSIPPALEASVQAITSESLNPDDVEIVTSSSHQPAAIGIDSSISHNDFAQLHAPPLHHHKSEESESTSLHASGFLPGLDDDTASNYGQLDPNDVRRLSFISFQDVVKSEHHHIASPLGDIGSRESLPIGGVLPPASLSDRAASPLQSPRSPTSINSQSVSGGGVTTPPPGVNVTNPLGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYZ2</accession>
    <name>F9WYZ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856042.1">
        <property type="nucleotide sequence ID" value="XM_003855994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYZ2"/>
    <dbReference type="FunCoup" id="F9WYZ2">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYZ2"/>
    <dbReference type="GeneID" id="13403177"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102151"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.454"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="InParanoid" id="F9WYZ2"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76658" checksum="3ED8B85C08154A4C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ36</accession>
    <name>F9WZ36_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_98370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857505.1">
        <property type="nucleotide sequence ID" value="XM_003857457.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WZ36">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ36"/>
    <dbReference type="GeneID" id="13403076"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98370"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZ36"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZW0</accession>
    <name>F9WZW0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857581.1">
        <property type="nucleotide sequence ID" value="XM_003857533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZW0"/>
    <dbReference type="FunCoup" id="F9WZW0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZW0"/>
    <dbReference type="GeneID" id="13394318"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33019"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010226_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZW0"/>
    <dbReference type="OMA" id="FQAQAFI"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="696" mass="75266" checksum="4CF4061C243B75B3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X071</accession>
    <name>F9X071_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">GCH</name>
        <name evidence="23" type="ORF">MYCGRDRAFT_66199</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857346.1">
        <property type="nucleotide sequence ID" value="XM_003857298.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X071">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X071"/>
    <dbReference type="GeneID" id="13394800"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66199"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="InParanoid" id="F9X071"/>
    <dbReference type="OMA" id="ATMSEFI"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389841" description="Vacuolar protein sorting/targeting protein 10" evidence="21">
        <location>
            <begin position="22"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1316"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1373"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="47"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="674"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1404"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1432"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGP92322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162482" checksum="63D12F6CF964BE17" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X085</accession>
    <name>F9X085_ZYMTI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">MYCGRDRAFT_19553</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGP91407.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9X085"/>
    <dbReference type="GeneID" id="13395064"/>
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    <dbReference type="eggNOG" id="ENOG502S8TF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126658_4_2_1"/>
    <dbReference type="InParanoid" id="F9X085"/>
    <dbReference type="OMA" id="RNHIRSE"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="7113" checksum="8EBF582383CEA915" modified="2011-10-19" version="1" fragment="single">TAANRKRGSKKRDNLTEEEKRRNHIQSEKKRREIIQQGYSDLNKLVPCLASGKSGLSRSECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>F9X1D6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857097.1">
        <property type="nucleotide sequence ID" value="XM_003857049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1D6"/>
    <dbReference type="GeneID" id="13398960"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107544"/>
    <dbReference type="eggNOG" id="ENOG502S40Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802080_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1D6"/>
    <dbReference type="OMA" id="RYNEDRA"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="417" mass="47505" checksum="34A2F510BD37C7AB" modified="2011-10-19" version="1">MENEWHNRTSYLLPYLTFKCQQSIPSLSLMHAFSRMGCPWQDHGLRLTSIADDYRVPFWELVTAVCHVLHVLLSRKILPSVQTNNLPPAELSPTRSRTDPPASPPHKHEKSHLARRLRSESLRNKPASNHHHHHYRHSARETVQSAIELRPPISFDSLLRRDKKTPDSSRNASSNQQRTPPIQQRNATYDGAAEQAQRVVVKPGDVKKAQDDNAKREKELRASLQNVEEVAMSSTRQLDDTYYTILDKASLLRSTVANLQQLAEESREMHATFQERTGKLEDDTRGLLQSFDNFNAQEKLIDDLVSQLKASKSQTAELNNRLEAARNRVEAYEKREKVKAANRRKRWGAIWGVLVGIVILVVAYVIARNRSAVGSRVHGVVEVMDRLGNELKASVSALKPMPSQSEDPYLKRLFDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Z4</accession>
    <name>F9X1Z4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_35508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854706.1">
        <property type="nucleotide sequence ID" value="XM_003854658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Z4"/>
    <dbReference type="FunCoup" id="F9X1Z4">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1Z4"/>
    <dbReference type="GeneID" id="13403751"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35508"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.41"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1Z4"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP89682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="328" mass="36427" checksum="2F42CF5A4346D31A" modified="2011-10-19" version="1">MGWFWADSTSTPAAPHPIPSKSSATPPPTCPMHNKSTAAMLPPPAPTPATESACPYKPPTDNDSPSSSTSSASPSYISKLNPLNYMPHSISNVREAAEQSVSLPLSRETSTIPRGDGEGTWEYPSPQQMYNAMLRKGYNDTPAEHVESMVAVHNFLNEGAWDEIRGWEGRFNAGLAKGWERCAKGEEGYERQIMMETLRRGRDAPEEPAPSLVRFTGRPNELTPKARMMSVMSRIYPSAFPDNPPFDRHDWFVRRVAPDGQTKEVRYVIDYYSGPPEPTGEPVFFLDVRPAVDGPVSAAERMMRWGGDVWWRASGGSVREELARQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A7</accession>
    <name>F9X2A7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_68282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855582.1">
        <property type="nucleotide sequence ID" value="XM_003855534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A7"/>
    <dbReference type="STRING" id="336722.F9X2A7"/>
    <dbReference type="GeneID" id="13403522"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68282"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="F9X2A7"/>
    <dbReference type="OMA" id="EGFRNCQ"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="177"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37485" checksum="F862332A3551BEAC" modified="2011-10-19" version="1">MKAARYYGATDIRIDHDAPEPIPGPRQLLVDVAWSGICGSDLHFWTIGPSPDRTLGLPSTLGHELCGTVRDPPVWSKFKHGDKVMVDPRICCRGCQACKDGTSAACSDLGYLGGTTEYGGFGERVVVKESELYLLPENIPLEYAAIIEPLAVVQHAIKVSGVKEWKGRDVLVLGGGPIGFALLLVLKAAGADRVIVSEPAAVRREQVKSLSKGVINPIEESVEKKCLELTDGRGAEVVFDCAGVPAGLESAFDAIRFNGLYVMIAVWEKPVSIPCMKFLAKHITMKGAYIFDDDSMGEVLDMMATGKLTGYEKMVTSHIGIDDIVDKGFKELIANKDSHIKILVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2P1</accession>
    <name>F9X2P1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_68017</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
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    <dbReference type="OMA" id="RCERMIL"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
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        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
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        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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        <location>
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            <end position="555"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89802.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="939" mass="102535" checksum="A23DE375DAC27956" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X330</accession>
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        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_55591</name>
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    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="eggNOG" id="KOG2011">
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003682">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007062">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Cohesin_Scc3/SA"/>
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    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
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    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
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    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126077" checksum="9BA1A99502B48006" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3G9</accession>
    <name>F9X3G9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_98983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855747.1">
        <property type="nucleotide sequence ID" value="XM_003855699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3G9"/>
    <dbReference type="STRING" id="336722.F9X3G9"/>
    <dbReference type="GeneID" id="13395961"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98983"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004757_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3G9"/>
    <dbReference type="OMA" id="NRHPQKA"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="10"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="490"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="666" mass="73064" checksum="2D7310B51DDAFE54" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3N6</accession>
    <name>F9X3N6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_103255</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854954.1">
        <property type="nucleotide sequence ID" value="XM_003854906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3N6"/>
    <dbReference type="FunCoup" id="F9X3N6">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3N6"/>
    <dbReference type="GeneID" id="13399594"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103255"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.611"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="InParanoid" id="F9X3N6"/>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="376" mass="39919" checksum="F3BC7FA95EA773EA" modified="2011-10-19" version="1">MATTDPKPIFIAIIGVGGVGKAFLTQLDTLRLRLSRSNPPTDLRLIYARRSTKQLFSTSWTHLDIPSLTATLDASGSPPPPFNETFGQLASGPGRVVLVDNTSSPDLGSLYPMILQRGISIVTPNKKAFSDNFALWSSIFSSAANGTGSPSAGYVFHESSVGAGLPVLSTLKELVETGDEVTKIEGVFSGTMSFLFNSFQPLGGGGGAFAAEVKNAKDLGYTEPDPRDDLNGLDVARKLTILARLAGLEVESPTSFPVQSLIPKELESCSSGDDFMTRLPEFDANMDELKDAATKENKVVRFVGSIDVASKQVKVGLEKFDASHPIAALKGSDNIINFYTKRYGSNPLIIQGAGAGGEVTAMGVTGDLIKVLRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X564</accession>
    <name>F9X564_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_57142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853995.1">
        <property type="nucleotide sequence ID" value="XM_003853947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X564"/>
    <dbReference type="STRING" id="336722.F9X564"/>
    <dbReference type="GeneID" id="13404333"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57142"/>
    <dbReference type="eggNOG" id="ENOG502RVAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126704_2_1_1"/>
    <dbReference type="InParanoid" id="F9X564"/>
    <dbReference type="OMA" id="TDVACWP"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="15371" checksum="7250C7DD71834491" modified="2011-10-19" version="1" fragment="single">MNGKPGTESPGSSASSSAVSPSTSRARARSSKREQVVAACYECRSKKVKCDAARPACGRCSSRSLSCYYDVEPETSRAVALKRKHESVQDDLDRMTELYDYIRSRSEGEVWDLVSQIRQTADPFKFLKLVRDRNGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5G6</accession>
    <name>F9X5G6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_38036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853635.1">
        <property type="nucleotide sequence ID" value="XM_003853587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5G6"/>
    <dbReference type="FunCoup" id="F9X5G6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5G6"/>
    <dbReference type="GeneID" id="13395839"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38036"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024994_1_1_1"/>
    <dbReference type="InParanoid" id="F9X5G6"/>
    <dbReference type="OMA" id="KECRSSM"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
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    <dbReference type="GO" id="GO:0005794">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="111"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="418" mass="45730" checksum="FA010D3E2A6D15C6" modified="2011-10-19" version="1">MTASTDGGFNTIDSSAGAGERRASVTVTNPFNFQTVQYERDSNAGKNELLGKRRGHKYRHSSIHAVHMDQIFKSPQIQRTPLSVPASLPLPTRRELWLSMTRHQTARLAWCAAHFAIAAYVQYSGAGSLAMTALSRLLLFDASGATVCVVVDVMGNFEVWKRSSIKHPFGLERADVLAGFGMAVFIAFMGLDVISHGIQHALENVGNHEAHSPHAHERVTMGHVDIASMLSIVSTLVSALLLKNHARIGRAMRFELLAGWGRILGNPSHFLTLSCSILLLLLPFLPTISYSIFDKVLAFTIASFMILLGARLGTSLASMLLMSFNATSSAERDGLKGIVEAIADADPAVSRVDEARFWQVHYGLCMANLKLRYRSSKGGYGMVGDDLVRIRKKVGEVVRKRLGGGRWDVSVQLAVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5N1</accession>
    <name>F9X5N1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854403.1">
        <property type="nucleotide sequence ID" value="XM_003854355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5N1"/>
    <dbReference type="GeneID" id="13404186"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91742"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.555"/>
    <dbReference type="HOGENOM" id="CLU_1856871_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5N1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="15125" checksum="95C409C35B5EF82E" modified="2011-10-19" version="1">MTPSMQQLVDLDHSAQQEQVGDGKHTGHAKDHGPLRSEGKAGVTKLSSSLGARTQARPLSTIFETVRTSTCYTQPLSPGSTPPDVDYSTKPDLEQYLSRKPEPRRKVSPSAAWRELDGTDVGKRTRKEQRKCHANAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6E9</accession>
    <name>F9X6E9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_103917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854051.1">
        <property type="nucleotide sequence ID" value="XM_003854003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6E9"/>
    <dbReference type="GeneID" id="13404570"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103917"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="F9X6E9"/>
    <dbReference type="OMA" id="PIAYTWD"/>
    <dbReference type="OrthoDB" id="3625086at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="251" mass="28147" checksum="23866D73A997052B" modified="2011-10-19" version="1" fragment="single">MFSIVVAMFSVATFFTIARFISRWPRLRGAGLSWDDGVVLFCFLPVTGLTIMALTMMHYGVGKDMWTLEIDTILTYAKYFYATQPLYNCSVLCTKLSLVLLYLRIWPREKGKGWTSFHVTCCIMIFALIGTTIAITLATTFACHPLHNAWRYANRAGGTCTDRVAGVYAYGGLNISYDIIVLALPITRLLRLKVSTTQKLGFIACFLVGIVATGCSIYRMFTIYGLTTARNITWDFTSVGLWSLIEVYVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6J9</accession>
    <name>F9X6J9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small-subunit processome Utp21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_99387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6J9"/>
    <dbReference type="FunCoup" id="F9X6J9">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X6J9"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99387"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.117"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="InParanoid" id="F9X6J9"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="830"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113537" checksum="E537613AFB0AACCD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6R6</accession>
    <name>F9X6R6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_91582</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854493.1">
        <property type="nucleotide sequence ID" value="XM_003854445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6R6"/>
    <dbReference type="GeneID" id="13404103"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91582"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.368"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X6R6"/>
    <dbReference type="OrthoDB" id="3648554at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="463"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1132" mass="122526" checksum="83F8298EF933D88E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6W0</accession>
    <name>F9X6W0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_70022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854360.1">
        <property type="nucleotide sequence ID" value="XM_003854312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6W0"/>
    <dbReference type="GeneID" id="13404248"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70022"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.667"/>
    <dbReference type="eggNOG" id="ENOG502SNM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129980_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6W0"/>
    <dbReference type="OMA" id="GNKHWNH"/>
    <dbReference type="OrthoDB" id="5176208at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391168" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="177" mass="19084" checksum="612B7FE2CF39CCDF" modified="2011-10-19" version="1">MQLSSLIVSMCLSGMANAVNFADYKPQAGVEGAFKDFLQALYSAAEDPKATKGFTDFFVPTTGQLFVKSLHGAGASKILGIKQMLMPTDGHKHWNHYPGVAKVGSETDTSKIYNVVGQIDTRYDGGNCSSAHFETNFEVLKDASGDVRLAPGSGSLALYDDYVVEPEYTPTEYPCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Z9</accession>
    <name>F9X7Z9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_103868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854290.1">
        <property type="nucleotide sequence ID" value="XM_003854242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7Z9"/>
    <dbReference type="FunCoup" id="F9X7Z9">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7Z9"/>
    <dbReference type="GeneID" id="13395476"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103868"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.823"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="InParanoid" id="F9X7Z9"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="226" mass="24344" checksum="5309E9CB3DBE0A1A" modified="2011-10-19" version="1">MASVNGDVSFDSIPDAVEAFAKGEFVLVMDSTNRENEGDLIIAAEDFTPAKAAFMIRHSSGYLCAPITSALAARLELPQMVTHNSDPNRTAYTITIDAADGVTTGISAQDRSLTCRRLADPKVQKETFRRPGHIVPLQAREGGVRVRGGHTEAGVDLCLLAGKQPVSVIAEMVQDGEEVEGKAELAGDFGMMRRDGCLAFARRYGLKVITIEDLIRHLEANDGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8M5</accession>
    <name>F9X8M5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853139.1">
        <property type="nucleotide sequence ID" value="XM_003853091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8M5"/>
    <dbReference type="GeneID" id="13399756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92846"/>
    <dbReference type="HOGENOM" id="CLU_1836708_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8M5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="15240" checksum="23296FD1F494CB58" modified="2011-10-19" version="1">MIGFPRVKHWVSNGIFNRLRKLKDEVRAPVLPTKRAHDEVHAAQTTATQNMLEPGMTAKLGMSLILINNGSHAVDIEPLVAAADRMGDEAGVRPSKNVHKLSRTTGFHAPTDATIKFAQPTLPMRPNPSGNGDTDRRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8U3</accession>
    <name>F9X8U3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_40431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853546.1">
        <property type="nucleotide sequence ID" value="XM_003853498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8U3"/>
    <dbReference type="FunCoup" id="F9X8U3">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="13397187"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40431"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="InParanoid" id="F9X8U3"/>
    <dbReference type="OMA" id="FLATCPM"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF2">
        <property type="entry name" value="C4-DICARBOXYLATE TRANSPORTER_MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="437" mass="48013" checksum="55788947E11BE148" modified="2011-10-19" version="1">MENNPAVTTPATSKLHPSQPNGVAPTEPQVSQSKPTSSPQHDSRNDHGWRRVVRNFSPSWFSVTMGTGVVAVLFINIPFQADWLHYLSIVFFILNTILFFLAFVISVLRYTIWPEIWSVMIRDPTNSLFLGTIPMGFVTLISAWISICVPAWGVWAVYFAFALWVLDSVVAIAVTVTLGILLMSASHQRSLDSITAAQLLPIAATIVASAVGSNIANVMPNPQLALGAIIASYVMWGMAVPMAFSVLVIYYQRLALHKMPPREVIVSAFLPLGPLGYGGYTVLNLGRAAVKVFPMTGSIDPIAGRIAYVMGFFVSLVMWGYGLIWFALALASIWKARPFPFNMGWWGFTFPLGVYSLSTILIGKELPSLFFRVLGTIFATCVILLWILIAVRTGKGAWTGKMFHAPCLANLKKQQEQMEEEKSIGSTSQNTQAEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9X1</accession>
    <name>F9X9X1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853602.1">
        <property type="nucleotide sequence ID" value="XM_003853554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9X1"/>
    <dbReference type="STRING" id="336722.F9X9X1"/>
    <dbReference type="GeneID" id="13397123"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92240"/>
    <dbReference type="HOGENOM" id="CLU_767708_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9X1"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655272" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="36591" checksum="04B1106171A56D37" modified="2011-10-19" version="1">MRALIAISLLGLVLAQQGPAVVQVITVVVKKSCGVVVGDPSTLGISSSFNASDGGGLPTVSRGIFSLTDGGNSSAFLSAPGTSGSGGLTGDGGVGGATSIPSSDLDEPSASNAVSGGLTLSEGVSGTPFSSSELDQESSTPGVAATTTSLENGDTSIESAPSSLPEPPSDGDESPSTSTPSPTARFTTISIPSSDFPTLPPPSAYTSIPISSQSPSAADTPTPSLGLVTSFIPYSGTDTGITAPTAVTTIPASGTVSGTVIVELPPEITSTRYWTGTEAFTTTVAASGTRAAYGICASNCLLAEGVYYDVYDVFTQYIFAGYHHHFHEYRGARYDDEYDDVIQFGGMYEGLYGMSVFQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAB6</accession>
    <name>F9XAB6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_100032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853282.1">
        <property type="nucleotide sequence ID" value="XM_003853234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAB6"/>
    <dbReference type="STRING" id="336722.F9XAB6"/>
    <dbReference type="GeneID" id="13399326"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100032"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.700"/>
    <dbReference type="eggNOG" id="ENOG502S3X1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="InParanoid" id="F9XAB6"/>
    <dbReference type="OMA" id="GFFMDTT"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="337" mass="37028" checksum="BA60C190AEC2BC14" modified="2011-10-19" version="1">MPSKIDLHSHFLPPFYRTALQTHGHANPDGMPAVPDWSETSHLALMDKLNISRSILSISSPGTHLIASDPSLAITLTRRCNAYAADLKRRHPSRFGFFASLPLPEIQASLDEIPKAISEDCDGFVLLTNAHGHYLGDEILNPIFEELNRRKAIVFIHPTTPKCPCSTESTAAGGQTPIPATPFAGRFPNPMLEFFFDTARIVTNLFLSGTVQRCPDIKFILPHLGGAFAPLLSRWTGFSGLVPGPWSGVSEEEVKAAFERQFWFDIAGFVFPSQIKGLVEGVGVSNERLVYGSDFPFTKAEGVEMLLGQMDVGVKGMFEEGETENLYHGNAERLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAE7</accession>
    <name>F9XAE7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aflatoxin regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AFL-R</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_109275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853263.1">
        <property type="nucleotide sequence ID" value="XM_003853215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAE7"/>
    <dbReference type="STRING" id="336722.F9XAE7"/>
    <dbReference type="GeneID" id="13399489"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109275"/>
    <dbReference type="eggNOG" id="ENOG502SIHU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082607_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAE7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390293" evidence="2">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="257" mass="28147" checksum="53886D0BFA05C1CD" modified="2011-10-19" version="1">MPILCLQSLPLVILVMLVILNMLMSCSMGKYVPQGLSCSMTKDGVRGPKREQVTNACTACRLSKLKCNGRHPTCYRCHARDLECVYDVSEGMTKRQHLNNELSEQKSELTQASAVLRVLQFGTDQEATASLARLRIGSTVGQEYQLLQAHSKPSLPEGVPVHVSRQQRAINTTRLQSETFAPWGCPPTTEAFSGSQQYEWDDSASDQLADWPQPCQIAREDSSGTVYSAVDSPLLDMALPTPASDGSLDDRKPCIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAH4</accession>
    <name>F9XAH4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_71681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852017.1">
        <property type="nucleotide sequence ID" value="XM_003851969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAH4"/>
    <dbReference type="GeneID" id="13393807"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71681"/>
    <dbReference type="eggNOG" id="ENOG502QUKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039562_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAH4"/>
    <dbReference type="OMA" id="TWSDWRS"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395570" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="61"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="409" mass="45245" checksum="EEC74AFDBD3F627C" modified="2011-10-19" version="1">MLLFPLLTLLASTLFKQALAFPNTPLTSSNRDILDTAGNKIVYKGVNWPGAADVMIPEGLQYQSIANIVSGIKSLGLNVVRLTFAIEMVDDIFSNSASSTLSNALNNALGSTNGPTVLAQILKKNPQFTASTTRLQVFDAVAAELANQGIWVHLDNHMSKGKWCCNGNDGNTWFGDSEFDVSKWQRGLAYMADHGKQWSSFASIGLRNELRHHDSSSPAQPYDWAHWYEAMVPAAEAVYKTNPNILIFFSGLDYDKDITALVNKQHLGSGHYFDPRSFDFGNRVVMELHNYQNNAKTCDSITSGLNHAGFNAMDVNNSGYYHVPVVLTEFGFDQNGKDYNSVYAQCIKTFMTGQPGGPGGWMQWALGGSYYIREGTQDFDETWGLYNHDWSAWRDANAIAYTKAFAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAK2</accession>
    <name>F9XAK2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852033.1">
        <property type="nucleotide sequence ID" value="XM_003851985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAK2"/>
    <dbReference type="GeneID" id="13393795"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92956"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.37"/>
    <dbReference type="HOGENOM" id="CLU_633412_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAK2"/>
    <dbReference type="OrthoDB" id="10549733at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="433" mass="47264" checksum="5E5F383CAB3D1D37" modified="2011-10-19" version="1">MATIHDPQTSASRRQRSKPSTATATTHSALHFHMSFEAGHGPSPLRNEIKEPSNDRAARPTRTTKRTQRSAPQQSSSVNNSDILSQEASPTPSDKVNNALGTTVPQLQTVVKKHAASDRSTSPDPPTFLDFSLSTTSFSLPSNPSDPYTTSPTSSTTPDRTLSHLSPSARALQLSLRQQARREQEQQSLYLESSLRHQLPISDPRHHIPGLDIHQRRHAALVRKAMMSRAEEWEREEEEEGEGRRREEKRSTIEERRAGVLARRAADQVNPTSPPASMRNSLGSLTSSTFRSPRRNSGLKKPSGEPLSEWDLGCGEVEKGEVDETSVWVEQLSRSLADCGVEGGIGGREGSVGEGEGEKKDYGHESDGGESMGMSLEEALAEAMEDVSGAVGGEPGGEAEVVSSKKDDGKEVEEWVEVDEEDLDGEWEEVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB44</accession>
    <name>F9XB44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_41798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852432.1">
        <property type="nucleotide sequence ID" value="XM_003852384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB44"/>
    <dbReference type="STRING" id="336722.F9XB44"/>
    <dbReference type="GeneID" id="13394209"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41798"/>
    <dbReference type="eggNOG" id="ENOG502RJG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_2_1_1"/>
    <dbReference type="InParanoid" id="F9XB44"/>
    <dbReference type="OMA" id="WVREQTI"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
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        <property type="entry name" value="Cupin_1"/>
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        <property type="entry name" value="GPI/OXD"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
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        <ligand>
            <name>Mn(2+)</name>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="365" mass="40141" checksum="68CD9E3B959FC0BF" modified="2011-10-19" version="1" fragment="single">GGTNSIIDIQNPSNLGQESTDTGVVPNLKWRFSDSKTALFNGGWAREQVITDLPASVDISSAQQHLKKGAYRELHWHRVSEWAFVYAGRVAISAVNEFGQNQYEILEVGDIWFFPKGVAHGVQGLDDENEFLLAFDDGDFEATGVTFNVDDWIAHTPKHILAKNFGVDVSVFQNTPKTNPKILQGIAPPDSTKADHPFGDLTETKLTYVIRSKDVPPTIVPGGGGSIQIFDSRNFPIATTIASSVVRIKPGGLRELHWHPNADEWVFFAQGQARATVFLGGSTARTFDFTAGDTAVFPSNSGHYVENTSPTEELIWIELYKADRVADISLTQWLALTPKEVVAQALNVSTEFVETLKQEKQVIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB4</accession>
    <name>F9XBB4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_104409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852704.1">
        <property type="nucleotide sequence ID" value="XM_003852656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB4"/>
    <dbReference type="FunCoup" id="F9XBB4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="GeneID" id="13397027"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104409"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.210"/>
    <dbReference type="eggNOG" id="ENOG502RZKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBB4"/>
    <dbReference type="OMA" id="ILWTAYP"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33196" checksum="CE93D6AEC5394442" modified="2011-10-19" version="1">MPTAMMIDPVQAFAAATSHVSLPTVVPVPSVEYQNATETGHRTLWVVFVVMLVSSIIFTGMAWSVPVSKRLYHIITTMITIFATLSYFAMASGHGISYNHTEVRESHKHVPDTTHDVYRQVYWARYVDWTVTTPLLLLDLALLAGLNGATIFITIVADIIMILTGLFAAFGTEGTPQKWGWYAIACIAYLVVIWMLVVHGRQSASGKGNKVGGFYASIGAFTLILWTIYPIIWGVADGSRILDVDEEIISYAVLDILAKPVFGAWLLFTHSRTPEMHADLGGFWANGLNGEGAIRVGDDDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBQ9</accession>
    <name>F9XBQ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_42167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
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    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
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            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30443" checksum="9CCD47030A5AFC36" modified="2011-10-19" version="1">MTSQVRGYIDPNFPNPMGPNDAYTPSLAVGVLGVVLFSIAAITHAYLLFRHRTWYFTPILVGTIMEIVGYVFRILSSQQDPYSVPWFVVQYFFIVVAPVMFSAAIYTLVSVMIDIYGRQYAPLPPKVVLAVFITCDVAATIIQVAGAALVGVAYSNQKDPTTYNNILLAGLAFQVFSFAVFLVVLAWTLVKARVSPAKISRSFITGLIIATLAVYLRTCFRLAETAEGLMEELSTHEVYFGCLEFAPVVVAVFIFTYWHPGRWLKADILEKHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC64</accession>
    <name>F9XC64_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93483"/>
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    <dbReference type="HOGENOM" id="CLU_645926_0_0_1"/>
    <dbReference type="InParanoid" id="F9XC64"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
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            <end position="78"/>
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            <end position="135"/>
        </location>
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        <location>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47658" checksum="4F49DC091109EF96" modified="2011-10-19" version="1">MDDRSLGPSDTELELEYEYKLQLWRHKARQLEHEEQGMRLEYEKARLARNRKGKRSVRSSSQGVEQGPGEKRTKRDTQDQITVGAKTVKVVDLSESHSPAAANSWEDRDMGFEDNEGAGGVLSDGAGDEELEDGSAAEQRHHGRFDDESGEEPMEEAQQSEEEESEEDGTEEKKVDDFPGMPTPAEWNPATRNRAPRNLQFKSINETFPTVCLMPNERLAELRCMECSGNMINRGGRKQALRPGASLLRHLKGAHGDKYKNSLTEYEVAYRSVVKWLGPAETAAVENEQKEGFFVEQIMVTKTITPEQAPAVDNGCCSCLRDPCEPQITSCSHIYCEQCVKILQDQAKRCGLDHPTCLKCGELFLSVTPLSDSASDKQQGSKSNYHAASAEDADEEEEEDVKPIIRLILRPSSSRPLQDLDRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC74</accession>
    <name>F9XC74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_42726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC74"/>
    <dbReference type="FunCoup" id="F9XC74">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XC74"/>
    <dbReference type="GeneID" id="13393958"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42726"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="InParanoid" id="F9XC74"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8387" checksum="C77BAB9BF753AEBC" modified="2011-10-19" version="1" fragment="single">VSVLLVNSIAILSEDRFLARIGWGSSAAAEPSFGGGNGMQGDASVKAKMINLINSVRTLMRIPLIFLNILIIVWAIAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD09</accession>
    <name>F9XD09_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_100453</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851901.1">
        <property type="nucleotide sequence ID" value="XM_003851853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD09"/>
    <dbReference type="FunCoup" id="F9XD09">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD09"/>
    <dbReference type="GeneID" id="13393678"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100453"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="InParanoid" id="F9XD09"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="369"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="902"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="954"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP86877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1164" mass="128599" checksum="3F558E851408F136" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD55</accession>
    <name>F9XD55_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_73025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851448.1">
        <property type="nucleotide sequence ID" value="XM_003851400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD55"/>
    <dbReference type="GeneID" id="13393650"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73025"/>
    <dbReference type="eggNOG" id="ENOG502SPT4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052060_0_1_1"/>
    <dbReference type="InParanoid" id="F9XD55"/>
    <dbReference type="OMA" id="DVERWAP"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="250" mass="27601" checksum="ABC87181EB1F636D" modified="2011-10-19" version="1">MPVYLLHGFRWPRPLIRIHIILQNLDDAAAEWLVAPGTTETMLENFHETFPDTMKHLPNLRFVEQYDPNDMSSLSQPYAYVADIVEEVKLGLDVDEVRGKEVSDEQTKALAAVRDKLAPEVPVGWYVVVCGDEERLAPGNEDEAEEEAVEAGQVEGQEVKGEETARESSVVTTKSFVLANGASGDAERTSKASTTADEKKQASTVQASTVEPEPKGLRKFFRRKSRATLQNLGSPVKDQAAPKVPSRVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDC5</accession>
    <name>F9XDC5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_43667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851491.1">
        <property type="nucleotide sequence ID" value="XM_003851443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDC5"/>
    <dbReference type="STRING" id="336722.F9XDC5"/>
    <dbReference type="GeneID" id="13393623"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43667"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.338"/>
    <dbReference type="eggNOG" id="ENOG502RXDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_8_4_1"/>
    <dbReference type="InParanoid" id="F9XDC5"/>
    <dbReference type="OMA" id="IQDTAWE"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="49"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="383" mass="41620" checksum="BCE66AAD7404AF99" modified="2011-10-19" version="1">MSSYTVQHLDSRTSYARPYILHNPHHASPSSSTSSLNPSVEAFHRTLPDYNETSLHNLSSIAEELGLKYVFLKDESTRFALPAFKILGASWAIHRAICQELALPNDASLEDVKQALRPTEKDVRLVLCSEGNWGRACARMGKILNLSVTIYVPGFMSEYMQNLLRGEGAEVKVLKEGTYDDSIAAALEDSERSGALLVMDTSWEGYEQIPKWVTEGYATMLTETDRQVAAITPENPNTFFVSVGVGSWAHSVVAHYTSANTSNRIVTVEPIAAPSFKESLHIGYPTPIVTGETIMAGMNCGTTSALAWSVLRDGVSDAVIVGENEAHDAVEELKGLGVSAGPCGAATLAALRRFVERISAEEKAEMSVVLFSTEGAREYVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDL7</accession>
    <name>F9XDL7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_30795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851806.1">
        <property type="nucleotide sequence ID" value="XM_003851758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDL7"/>
    <dbReference type="STRING" id="336722.F9XDL7"/>
    <dbReference type="GeneID" id="13402170"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30795"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_5_1"/>
    <dbReference type="InParanoid" id="F9XDL7"/>
    <dbReference type="OMA" id="YVPSKKF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="12824" checksum="1D4EC09FA1A5B810" modified="2011-10-19" version="1" fragment="single">TVVRKGGGEKWEDKSLLEWDPTQFRIMVGNLAGEVTDDSLAKAFAAYGVAKARVIRDKLSTKSKGYGFVSFTDAEMGFKAAREMSNKYIGSHPITIKRSRTDVKPVVKKDPRNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDQ4</accession>
    <name>F9XDQ4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_94000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851560.1">
        <property type="nucleotide sequence ID" value="XM_003851512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDQ4"/>
    <dbReference type="STRING" id="336722.F9XDQ4"/>
    <dbReference type="GeneID" id="13401695"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94000"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.479"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="F9XDQ4"/>
    <dbReference type="OMA" id="HKHMEDA"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="36756" checksum="3AA5FB593E5F94AA" modified="2011-10-19" version="1">MATMRAVEIKDGKGPLENLHITEIKRPSISSSQALVKVRAFGLNRMDLLQREGKYPVPPQAPSTLGVEFSGTIEEVADGNEEGYKKGDEVFGLAYGGAYAEYIAVSTHMLVKKPEELSWEECAGIPEVYITALQAMYLIGEFEPGKSILWHAGASSVGIAGQQLSKVNGASKVFATARSDDKCNWCVSDLGATAAYNSTNTDWAEEVLKATDNKGVDIIVDFIGPDTFAADLKAIAKDGRIVNLATLSGLHLKDTNANFGAFVAKRVRYEGSSLRSRDEKYQGKLRNHLVEHALPMFKDGRLRSIVEKVFPWEQIQEAHKLMESNQTKGKIICTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE73</accession>
    <name>F9XE73_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_22464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851628.1">
        <property type="nucleotide sequence ID" value="XM_003851580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE73"/>
    <dbReference type="GeneID" id="13401839"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22464"/>
    <dbReference type="eggNOG" id="ENOG502SI9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_2_1"/>
    <dbReference type="InParanoid" id="F9XE73"/>
    <dbReference type="OMA" id="HDARWIN"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52196" checksum="5949E4C29F779325" modified="2011-10-19" version="1" fragment="single">RPDILAPILHNRVASHDAVEPGYIFFSVWGGVGQWAPYIYDSDLNLVWSGYDPAFSALGHYNFQAHHYANGTQLLSVFRGMSVGGRGRGSVLLLDDSYTITHNIRSSSPAFALDFHEVSIRAESNTAIITAYPTRRMDLSLFDVTESMGWVLDSLFQEIDLDSGSVVFEWTASDHIPLEETTISPALKHGGGLSSHFPFDYCHVNSVDKFANGDYLISSRHTNTIYRISHVDGSILWRLNGDNSSTAETYIPLQDYNFAAQHDARVRRESANGNEIELTLVDNADNGQYYTQDYSSALRVAISFASGRATSRLLQTWLPFEDGQAEHQGTVQYDMPVTGNTLVSWGEIAEFSEFSPSGKRVLDVAFADELLHVYRVMKASWIGRPKTKPDLYMYARSRDEKTQFYMSWNGATEVKEWRCFAIEGDVRANLGVVKREGFETHFEWDGEVDRGMVEALDGDGHVLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE91</accession>
    <name>F9XE91_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_44402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851713.1">
        <property type="nucleotide sequence ID" value="XM_003851665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE91"/>
    <dbReference type="STRING" id="336722.F9XE91"/>
    <dbReference type="GeneID" id="13401846"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44402"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093619_4_0_1"/>
    <dbReference type="InParanoid" id="F9XE91"/>
    <dbReference type="OMA" id="NSMPHEN"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="6">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="15004" checksum="5ADB34554C147149" modified="2011-10-19" version="1">MQRAPPYTLEGEGDRVLSKRKLDELVRQVTGAAPSTDNSESTSILMPDVEESMMEVADNFVDEVITAACKLAKLRGSQTLDLRDIQMVLERNYGIRIPGYSLDEVRTVRKFQPAPGWQSKMQAVQAGKVMGSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEB5</accession>
    <name>F9XEB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851988.1">
        <property type="nucleotide sequence ID" value="XM_003851940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEB5"/>
    <dbReference type="STRING" id="336722.F9XEB5"/>
    <dbReference type="GeneID" id="13401233"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109710"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.44"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_1_1"/>
    <dbReference type="InParanoid" id="F9XEB5"/>
    <dbReference type="OMA" id="FAKRGNT"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395618" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="200" mass="21613" checksum="D9D49F1AC368DA3C" modified="2011-10-19" version="1">MFFSTFATLALATVASCMPTAELEERAPVGYSYKDAVLYHHNLHRANHSSPALVWDTNLETIARDTAKTCQYKHNTTAGGGGYGQNIAAGIPYTNIGYVISDLFYNSEVNNYNQYGQQKTDFSNFGSWGHFSQIVWKSTGRIGCATIGCPNGLANVGSNVPPWFTVCNYAGPGNYANDGQFAVNVLKPKGNPTIHANAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEH8</accession>
    <name>F9XEH8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_73547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851651.1">
        <property type="nucleotide sequence ID" value="XM_003851603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEH8"/>
    <dbReference type="FunCoup" id="F9XEH8">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEH8"/>
    <dbReference type="GeneID" id="13401984"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73547"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="InParanoid" id="F9XEH8"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="500" mass="53759" checksum="9EBBBD73830E3D89" modified="2011-10-19" version="1">MSSDTVSSSARGAGFLILLQISSRALTFALNQVLLRFLSPALLGASVQLELYIISAHHFARESLRVACQRQPEGGIQAAINLSYLAIAGGCPIALFLAQWYLSTSYPDVPYFVEALRICELAAIVELFSEPAFVAVQQNMLYKTRAAAEASAVVVKTFTTAAIVFWGQHKDIELGVLPFAAGELAYCSILTLVYLWQTVPVARLQKFSLLPRVFSSRCNQFVLGLFSKPLLNLSVSLYIQSGIKYVLTQGDVIVSTALASLEDQGMYALSANYGGLIARMVFRPIEDSTRNMFAKLCAPTTTPTASLAQAATILRDILRIYTIFSLIAFAVGPSAAPLLLQLVAGSRWSASGAGEVLGTYCYCIPLLAINGVSEAFVAATASTKDLHWQSIWMGAFSAGFAASAYIFLRVLELGANGLVWANCVNMGLRIVFNFFFVSSYFKRNGQDFNLVDILPNPYAIAATAVVPSLLARSGSLTAQYGLLGDLVRVGGVGAAFALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEI3</accession>
    <name>F9XEI3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sec23/Sec24 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_73550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851654.1">
        <property type="nucleotide sequence ID" value="XM_003851606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEI3"/>
    <dbReference type="FunCoup" id="F9XEI3">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEI3"/>
    <dbReference type="GeneID" id="13401982"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73550"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_2_1"/>
    <dbReference type="InParanoid" id="F9XEI3"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="286"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="553"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="649"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="776"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP86630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="99472" checksum="30173CE386515679" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEM0</accession>
    <name>F9XEM0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851677.1">
        <property type="nucleotide sequence ID" value="XM_003851629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEM0"/>
    <dbReference type="STRING" id="336722.F9XEM0"/>
    <dbReference type="GeneID" id="13401889"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94194"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.716"/>
    <dbReference type="eggNOG" id="ENOG502TAM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251550_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEM0"/>
    <dbReference type="OMA" id="HKCIVSN"/>
    <dbReference type="OrthoDB" id="3644790at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="221" mass="24580" checksum="B910D7DB7E2ED1A0" modified="2011-10-19" version="1">MAPAGGTSASALKHMFDTGEWSDLEIITASKTFKVHKSVVCQSPFFRAACTGRGVREAASGKIDLEESEDVVNAILCHLYELPIVWLKQRYDYKTAEMIFPRGRDAIDLIVAADNYDISGLAKEAYDKFISCIFCTDIAPKHHIALGELFLAEVDAEPFRTDGRLAIAKSTNEIMKLIIKDRSLWNKLYANEAYVKLLLGYTPGAEQARAAKRPRVTEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFD5</accession>
    <name>F9XFD5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CYP-5</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_44640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850661.1">
        <property type="nucleotide sequence ID" value="XM_003850613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFD5"/>
    <dbReference type="GeneID" id="13397945"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44640"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="InParanoid" id="F9XFD5"/>
    <dbReference type="OMA" id="WTEHALE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="523" mass="59153" checksum="029C3F72F51B31FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHA5</accession>
    <name>F9XHA5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_219684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="630"/>
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            <begin position="56"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <sequence length="654" mass="72741" checksum="A414FB1C28756328" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP0</accession>
    <name>F9XHP0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">MYCGRDRAFT_46633</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNase T2 family.</text>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease T2-like"/>
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    </dbReference>
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        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395519" description="ribonuclease T2" evidence="7">
        <location>
            <begin position="18"/>
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            <position position="82"/>
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    </evidence>
    <sequence length="316" mass="34975" checksum="4F8B0D482530E7D8" modified="2011-10-19" version="1">MRSAIAITGLLAASTSAELYSGLSQSNHSCSIQPAYRSCSKKANPASADTCCTETFGGLILSTQFWDTWSENPLPPNEFTLHGLWPDFCNGSYTQYCDLSRQYDPFPSPNTTNGLPNGTVVPAYNGTGVDTFLEAFGLYDLLAWMNKHWVAQTGPNHVLWAHEFSKHGTCYSTFDLPCYGPKYVEHEEFVDYVETAIRYQRQLPTWEWLAGHGILPSNSTGYTRSDLENALTEEYGAVPYLGCSGPRYNETDAGKAAKTNDTGRTVLGEVWYFRHVNGRPQDGHAVPVDSPSVSGCTNATNALWYYEQTAQNATKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP8</accession>
    <name>F9XHP8_ZYMTI</name>
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        <submittedName>
            <fullName evidence="9">Transcriptional repressor TUP1</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">TUP2401</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_100978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
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            <end position="160"/>
        </location>
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            <end position="191"/>
        </location>
    </feature>
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            <begin position="206"/>
            <end position="217"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="603" mass="65299" checksum="DF77DCA86EAF8E44" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHQ6</accession>
    <name>F9XHQ6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_61626</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850042.1">
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    <dbReference type="AlphaFoldDB" id="F9XHQ6"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XHQ6"/>
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    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="189" mass="21538" checksum="F0D7141BA0EC0FA6" modified="2011-10-19" version="1" fragment="single">MAAIDPRVAQVLDSRRTEHDSDDEDALIAELEEDDDGAFSALREKRLEQLHAEVSRAKLMKETLHGTYMEIKDERQLMDITTSTKLCVVHFMKPDFNRCRIMDEKLKVLAEKHFDTRFVNINVENAPFLVVKLNVKVLPCVLTFKDGVSSDRIIGFEGIGWKPDSFTTSELEARLLASGVLLRPKMTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHR5</accession>
    <name>F9XHR5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_46398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849861.1">
        <property type="nucleotide sequence ID" value="XM_003849813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHR5"/>
    <dbReference type="GeneID" id="13395281"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46398"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="F9XHR5"/>
    <dbReference type="OMA" id="CCMFAFF"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="473" mass="50909" checksum="59D86393BB4F2462" modified="2011-10-19" version="1">MPPFAQKYGDGTAQLAPGVPALSSQDQSLLVSVPNSGCLLGLPLAAYLGDRIGRKRTLLVGCVINIAAAILQVVAPNMAAMVIGRWFTNASIFIFITMASTLMAETSPPAIRGIITGLSIVLIDASAILATGVNYAFSKGTTARAYRVPLSIQIIFGFVILVSTLFVSDSPSFFLTKSKDVEALSALRLLRRGYTETEILAEFEDLKAQKAIREETEQVPFKALFQGTDLRRTLLALSIPNMQQMSGIAFATNYVVVFLSTIGSTVSPFVLSMVVALLAFTGAIVGLFLVDKVGRRVLALTSFSALFVINMIVGIMGFLPVTNPMVPKVIAAFCCMFGFFFAVGFGPLTYVVAAEMPTARLRNRSSSFTFLTLACFATVVTYVLPYIVNKDAAGLGPKTYLIFAGWMAGCIAVIYVYLPETQGRSPAELDEMFGAGIPARQFKHYVCQVSVDAHILAEKEAAVEQAVTIERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHT1</accession>
    <name>F9XHT1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_46275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850545.1">
        <property type="nucleotide sequence ID" value="XM_003850497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHT1"/>
    <dbReference type="FunCoup" id="F9XHT1">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHT1"/>
    <dbReference type="GeneID" id="13395198"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46275"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827822_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHT1"/>
    <dbReference type="OMA" id="HTRFSNE"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="33978" checksum="502173418399680C" modified="2011-10-19" version="1" fragment="single">MSTTAPPTQPATTSAEPPAVRNERQRNEHYQIKHINWLDTSSDGQGGYRKSPVLTQTANGPCPLLALVNALVLSTPRDLETALITTLRSREQVSLGLLLDAVFDELTSDRRGDTAQALPDVSDLYAFLLALHTGMNVNPRFSKAGSFEETREMRLYSTFGIPLIHGWTAPKDTPVFLAFQRSAPTFEDAQNIQFMEAELEDKLRQEGLSFQEQQTLEDIATIKSFLQTWPTQLTDHGLEMIAGCLKPGQIAILFRNDHFSTIYKEPQHGALMTLVTDAGYSSHEEIVWESLVDVSGAACEMFSGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIA7</accession>
    <name>F9XIA7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_101026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850087.1">
        <property type="nucleotide sequence ID" value="XM_003850039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIA7"/>
    <dbReference type="STRING" id="336722.F9XIA7"/>
    <dbReference type="GeneID" id="13394745"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101026"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="InParanoid" id="F9XIA7"/>
    <dbReference type="OMA" id="QREGILC"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="201"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="603" mass="68168" checksum="819428614B6FA93C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIF8</accession>
    <name>F9XIF8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_19626</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850438.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XIF8"/>
    <dbReference type="GeneID" id="13395139"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19626"/>
    <dbReference type="eggNOG" id="ENOG502SBXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85462.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="78" mass="8605" checksum="34F460D04E4D492A" modified="2011-10-19" version="1" fragment="single">PRPNITGFDPAKFAAASGQPKNDPWARVEAWRYTGPFTRRNRFKNSFPGLGIATVAFAGYLVYEQVFMAPAHGHGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIJ0</accession>
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        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
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    </protein>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850257.1"/>
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    <dbReference type="GeneID" id="13394380"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101041"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.524"/>
    <dbReference type="eggNOG" id="KOG2226">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIJ0"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hid1"/>
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    </dbReference>
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        <location>
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            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="612"/>
        </location>
    </feature>
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        <location>
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            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96639" checksum="E6C9DAA5A1CA682A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ10</accession>
    <name>F9XJ10_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">MYCGRDRAFT_75314</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849828.1">
        <property type="nucleotide sequence ID" value="XM_003849780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ10"/>
    <dbReference type="FunCoup" id="F9XJ10">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJ10"/>
    <dbReference type="GeneID" id="13398918"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75314"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.81"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_2_1"/>
    <dbReference type="InParanoid" id="F9XJ10"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000002">
        <property type="term" value="P:negative regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001034">
        <property type="term" value="P:positive regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="427" mass="46624" checksum="29596224F2F52568" modified="2011-10-19" version="1">MSDLDKAIAQLRACRPIPEVQVRELCYKARELLIEEGNVVSVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECLRKYGSANVWRYCCEVFDYLALGALVMGAATDLDPTDAAFADPAQANPDSEDIEIEILNAQGQIINRFPRARPTTSTETSQLSNPPSSPSQPQQQPTGPPGTGATSSAKGSSSHNPGGAVLCVHGGLSPLIDSIDKIRLLDRKQEVPHEGAMCDLLWSDPDDIDGWGLSPRGAGFLFGADIVKCFNHKNDLSLICRAHQLVMEGFKEMFDSTIVTVWSAPNYCYRCGNVAAILELGEDGANAGYAGRGNGDVGRSLGLGERNTAGVEQKMGPGRRYRVFDAAPQDSRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ22</accession>
    <name>F9XJ22_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849818.1">
        <property type="nucleotide sequence ID" value="XM_003849770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ22"/>
    <dbReference type="GeneID" id="13402615"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95553"/>
    <dbReference type="eggNOG" id="ENOG502S8B5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327110_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ22"/>
    <dbReference type="OrthoDB" id="3629726at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="880" mass="99934" checksum="CDCDC17166801D7A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ47</accession>
    <name>F9XJ47_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_28593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849803.1">
        <property type="nucleotide sequence ID" value="XM_003849755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ47"/>
    <dbReference type="FunCoup" id="F9XJ47">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJ47"/>
    <dbReference type="GeneID" id="13402600"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28593"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_1_1"/>
    <dbReference type="InParanoid" id="F9XJ47"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14600" checksum="DAFEB3D55423DBAB" modified="2011-10-19" version="1" fragment="single">RSFSTTPSRFATYNQVLRGCRVEQRARKPTSPALVNRPEMKGVCLRVGTTKPKKPNSGERKVARVRLSSGRVITAYIPGEGHNVQQHSVVLVRGGRSQDCPGVKYHLVRGAMDLGGVGNRVTSRSKYGTKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ98</accession>
    <name>F9XJ98_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_87539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849439.1">
        <property type="nucleotide sequence ID" value="XM_003849391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ98"/>
    <dbReference type="GeneID" id="13402234"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87539"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="InParanoid" id="F9XJ98"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="216"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="369" mass="39449" checksum="FBFF72CEC4543895" modified="2011-10-19" version="1">MTQVKAVLFSWINILLIAVPVGIALEQVKSFSRVGVFVINFIAIIPLAAILSFATEELAMYIGEVLGGLLNASFGNAVELIVSVIALKQGKVIIVQTSLIGSMLSNLLLVLGMCFFFGGINRSEQFFNITVAQTAASLLALAIGSLIIPTAFAMFSPKGEQGVAQASRGTAVLLLVTYACYLLFQLRTHKTMYNEPSQKEDDEEEETPSLSIIGALITLGIATVLIAFCAEYMVSAIGAIADSISPEFIGLILIPIVGNAAEHATAVTVAIKDKMDLAIGVAVGSSLQIALLVLPLMIMLNWWGVGDAVLTLNFDGFLVVVLVLSIWLVNYLINDGKSHWLEGVMLMLLYTIIAVAAFFYPANKEDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJD4</accession>
    <name>F9XJD4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_75734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849460.1">
        <property type="nucleotide sequence ID" value="XM_003849412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJD4"/>
    <dbReference type="FunCoup" id="F9XJD4">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="GeneID" id="13402255"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75734"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="InParanoid" id="F9XJD4"/>
    <dbReference type="OMA" id="NYLANYH"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47880" checksum="A9A7D4A0D6281F75" modified="2011-10-19" version="1">MPVYIALQAIFEGIGSIPYIWPILKTVPWIALLWVLKTFFSGASNLSERNMHGKVILVTGGTSGVGEATVRELATRGAQIVLLTQHSLSDPFIVDFIEDLRNDTNNHLITAEQVDLASLHSIRQFATKWIDNAPPRRLDMIVLCANTLTPGSKEPKSTAEGVELNWQINYLANFHLLSILSPALRAQPPDRDVRVLLGTCSSYLGGDLLHITQSGSGGASGKSGSKSRAPTQSPTRFSPGNAYATSKLALNTFALAFQKHLSTFARPDKMPMNSKVLLVDPGWCRTPGTRRWLTFGSLFGLALYLLMYPLWVFVLKSPRMGAQSFLYASMEEKFSRSEGGILIKECIEREFMRAEVMDEDAQKQLWEYSEQMVQEAEKRGATERARAKKEAEERKDEEDAMKEMKDYKEKVGKKDGQKKDGSRRAKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJZ4</accession>
    <name>F9XJZ4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_48260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="F9XJZ4"/>
    <dbReference type="GeneID" id="13402530"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48260"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.269"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="InParanoid" id="F9XJZ4"/>
    <dbReference type="OMA" id="TMVNPQN"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390720" evidence="1">
        <location>
            <begin position="19"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="282"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="789" mass="86763" checksum="42C092A187190007" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP5</accession>
    <name>F9XKP5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_101410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
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            <end position="294"/>
        </location>
    </feature>
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            <begin position="83"/>
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            <end position="175"/>
        </location>
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        </location>
    </feature>
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            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="294" mass="30242" checksum="12D1903CD3826D2C" modified="2011-10-19" version="1">MADFAPPPGPPPPKVPEGYKAIWNDQYKEWFYVNIYTKQSTWERPTEPVYPPPEGAPHDAPPGYNNDTKPNPHYGDDKSAMHSNNPYNANAAGGSSSISEDERLARQLQAEEDARNGNRGASDNYYGGGAPQYGNQAPQYGSSSNQLPARDQGKKGGLLGKLKGALSSGGSSSRPMGGGGYPQQGYGGYPQQGMMGGGYGHGPQYGGYPQQGYGGYPQQGGMMGGGGMMGGGRRPGGGGMGMMGGAALGAGAGLLGGAMLANSFDDHEDYQEGYQDGQDDGGDYGGGDDGGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKZ9</accession>
    <name>F9XKZ9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="22"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
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        <location>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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        </location>
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            <end position="186"/>
        </location>
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            <end position="212"/>
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            <end position="238"/>
        </location>
    </feature>
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            <end position="276"/>
        </location>
    </feature>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="373" mass="37188" checksum="594F42AE6D39233A" modified="2011-10-19" version="1">MDPTTPDAGPDHAPPSLPPGWIAQFDAKSRRYYFVQISTGESTWETPTMAAQNVPSPGTTPANQSPYPVPGETSRGVDGQEGDRSLGGSLLNSMLGSNKQSSGGGLGGLASSFLGGSSSSHGGSQQHGQQGHSSGGGGLGGIAQSFLGGSSSSHGGQSGQHGSSGHSSSGGGLGQLGSMASSLLGGKTSKPHSGGNPYGYSQNQSSGGTYQGSAPPASYQPAGAHGGGSQGASYGGSHGSSTPGSYGQHGGHAQPSHQPQYGAPQQGNFGPSSGAYNPQGQQGYNQPPGGYSGPPSQQHTPHNAQYGQQQQPGGYGGQYPPPPQGQYGQPQSGGYGGQPSYDQGYGQQQSQYQSYGQPQGGYGGQPPPNPGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL54</accession>
    <name>F9XL54_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7 domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="668"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="297"/>
            <end position="325"/>
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    </feature>
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        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
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        <location>
            <begin position="1597"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1866"/>
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        </location>
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        <location>
            <begin position="24"/>
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        </location>
    </feature>
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        <location>
            <begin position="236"/>
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        </location>
    </feature>
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        <location>
            <begin position="311"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1073"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1895" mass="211202" checksum="2C93DBDE3295483D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLF5</accession>
    <name>F9XLF5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_101457</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.348"/>
    <dbReference type="eggNOG" id="KOG3459">
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    <dbReference type="InParanoid" id="F9XLF5"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13789" checksum="59CAF50DAE77F1DB" modified="2011-10-19" version="1">MASAAAPDAKIQELLAKPRAELTEYEIGLLETHEFTSGPLSLLQTAVRNHAQVLISCRNNRKMLARVKAFDRHCNMVLENVKEMWTEVPRLTDGKKGRPVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLS5</accession>
    <name>F9XLS5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_82455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849062.1">
        <property type="nucleotide sequence ID" value="XM_003849014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLS5"/>
    <dbReference type="GeneID" id="13398459"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82455"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.420"/>
    <dbReference type="HOGENOM" id="CLU_3038224_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLS5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="55" mass="5970" checksum="F539B7716C23987B" modified="2011-10-19" version="1" fragment="single">MVASDNAQFEPVPLVQTFNSLHPYHIPLPTHRSAHGTCQSSGSFWTHAGPTNPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLT8</accession>
    <name>F9XLT8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamin pyrophosphokinase thiamin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_17404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848942.1">
        <property type="nucleotide sequence ID" value="XM_003848894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLT8"/>
    <dbReference type="FunCoup" id="F9XLT8">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLT8"/>
    <dbReference type="GeneID" id="13398450"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17404"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLT8"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="230" mass="25738" checksum="C776F57235C1AF81" modified="2011-10-19" version="1" fragment="single">ALIVLNTPLDDLDYFRRLKSHAKFTLCADGGANRLHDLCIEQSPGNSWRKALSADLPDLIHGDLDSLRDDVRAHYAELGVKITQDPDQYSTDFGKAIKQVVEHLPSAREVLVLGSVGGRVDQGIGLLHELYREQKVDHSRLRFWFFSESSITFLLWPGTTKIETPLKEGLITPNVGILPLYGKAVITTQGLEWDVEDWPTEMGGQMSASNHIVQDHISIKTDVHVLFTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLU0</accession>
    <name>F9XLU0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_48751</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848944.1">
        <property type="nucleotide sequence ID" value="XM_003848896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLU0"/>
    <dbReference type="FunCoup" id="F9XLU0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLU0"/>
    <dbReference type="GeneID" id="13398189"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48751"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XLU0"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="161"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="447"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="551" mass="60423" checksum="86ACF3FC5A1AD179" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMC0</accession>
    <name>F9XMC0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_18814</name>
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    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085757_4_1_1"/>
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    <dbReference type="OMA" id="FYSTPAY"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="93" mass="10756" checksum="D6DE92890FB8FF97" modified="2011-10-19" version="1" fragment="single">VEPLNAEQCAPNLPYFVSRSANNELPIYTLRKRGGNLKMTRIKKIDGDRHILRDELKSLLKNSDCVVNSVTGHIMIKGHHKPQVEKFLRERMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMC5</accession>
    <name>F9XMC5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_77140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848445.1"/>
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    <dbReference type="AlphaFoldDB" id="F9XMC5"/>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XMC5"/>
    <dbReference type="GeneID" id="13396206"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77140"/>
    <dbReference type="eggNOG" id="KOG2997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017706_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMC5"/>
    <dbReference type="OMA" id="SWSQVFQ"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="531" mass="59797" checksum="02CBEBEC4B6FA402" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMJ8</accession>
    <name>F9XMJ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MgCHI2</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_49750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848284.1">
        <property type="nucleotide sequence ID" value="XM_003848236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMJ8"/>
    <dbReference type="FunCoup" id="F9XMJ8">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMJ8"/>
    <dbReference type="GeneID" id="13396364"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49750"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="InParanoid" id="F9XMJ8"/>
    <dbReference type="OMA" id="NWNLMAF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="8"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="422" mass="47266" checksum="84E8262DE74824B5" modified="2011-10-19" version="1">MSGLQRGYRSVAYYVNWAIYARNHPPQDIPASRLTHVNYAFMGINNITSEVILTDEFADVQKMWPGDVATDYTNTTSSHDAMTHDTTNGTSNELEMFGSLKQLYLHKKHNRHLKTMMVIGGWSLRKAFAPALATDSGRKNFAKTTVQLIKDLGFDGVELDYEYPSSAQEAADLVSACQVIREELDSYSRSLNGNPHFLLALSVPAGPINYVHFDVPGFKPYVDFINLMAYDYQGSVFSNYSGHDANVFKSIDNPRSTDFETEDPLMYYLNAGMPAEGITMGMPLYGRSFANTSGPGMTYTNATDGSWEPAVWDYKAMPQNGSQVYTDNTIVASWCYNKDTRYMVSYDTPEIAVQKTHYIVGKGLGGAMWWETSGDFKVDDQRSLIRTVTTELGNFGGMETSMNVLDYPQSKYRNLREGMPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMU5</accession>
    <name>F9XMU5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848326.1">
        <property type="nucleotide sequence ID" value="XM_003848278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMU5"/>
    <dbReference type="GeneID" id="13396125"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96575"/>
    <dbReference type="HOGENOM" id="CLU_1278513_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMU5"/>
    <dbReference type="OrthoDB" id="10643970at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="23896" checksum="A8583AE9F64AF259" modified="2011-10-19" version="1">MGSGIVGIDKSRAHEDGALIKKHVLQRQNLYYQRAFPSSSAPRDTTGTDFDFWRIACPDLQWMTLRHGDKAIVALSRAFEHIRLEQTELARQDAMQTISNSLRDFDFFVTDMGNAGSVHRGLADIGDSILILAGAPSPFCARRVPTSSQKQFALKSVCLVDSQRSLTWSATEKHHGAITYTPAAVSSSIELRLICVEAIRELIQNLPYLVAIPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN11</accession>
    <name>F9XN11_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_106114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848355.1">
        <property type="nucleotide sequence ID" value="XM_003848307.1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribosomal protein S26e"/>
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        <property type="entry name" value="Ribosomal_eS26"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="125" mass="13938" checksum="3DB9878BB75C0F6B" modified="2011-10-19" version="1">MVKKRASNGRNKNGRGHTKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYAVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKVNPGQVAKIPGAQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN51</accession>
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        <name type="common">Speckled leaf blotch fungus</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN51"/>
    <dbReference type="GeneID" id="13396152"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88038"/>
    <dbReference type="eggNOG" id="ENOG502ST8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029950_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN51"/>
    <dbReference type="OMA" id="QIYCASC"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83350.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="507" mass="55574" checksum="9D34DDC5A63DD75D" modified="2011-10-19" version="1">MPPRTAANNLTSSFNIADANNEVVCPLRNQDGSNCRKRCLGEKRFRSMQEHIRRAHPEYYIPKLPATKESFELMINTPPHEIPPPQENNNNNNTPNNSTSVLRQLQHTQQLSDPSGYHALGGHDGGYYTAGDAEAAAIFTNMQFQQRSSDEYRRGSLIPAASAAAALAQLHSHRGADSDWPTESMGQQVIFPSLQMSPTVTEADLLQDYYGSNNDLKSNPFHVDPQLEDNSYLHDHSQFQPNSHSDGPAGLISPSDRPSTLPPLQRSLSRGGHSNRPRKSSLSQQARMAKHERKRSKDLIKRSSGGDRKAFSAEPSNNPAFLYGKRWEDLIDAAASATEEEDSRDLTPIPASPYQSPQVASRTSLPPPFGGLGAQFTSFQASPLNRALTPPDANHHSGLDMQTFPSVDDSSLSSNLSHQHHNSADSGSQFQIMNPSSIDSTSSEIYCAGCRRLCSLKEAFACTGCICGLCGVCANAIVSEQSRGRMSMCPRCHVMDSSYKPFALDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNW9</accession>
    <name>F9XNW9_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97103</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNW9"/>
    <dbReference type="GeneID" id="13401616"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97103"/>
    <dbReference type="eggNOG" id="ENOG502SCE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090737_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNW9"/>
    <dbReference type="OMA" id="WQRRDIE"/>
    <dbReference type="OrthoDB" id="5279705at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28835" checksum="60430DF7E58FEBB7" modified="2011-10-19" version="1">MATTNENTVPNTKPEPANTTFIFSAPPPPRREVSDQNLPFAQRRIKVAPPVARAGDLKEKRRGQFLKKVERGREEERWERRGDDILRMDFMQRQREWEAAQARSAAALALEESAYEEEEDDEMDGGEDRMPETIDLPTFSSSGLGSQMQMSSQRGLASSAPQQPQVELSDEDEIDRLIRDEDEELEMLLSYMPTDQGDDYGTATGHQQAGDDGDSLWSDDADYDALFSEVLNQEAQMQQAHQQPNETADVEMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNX3</accession>
    <name>F9XNX3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_50246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848117.1">
        <property type="nucleotide sequence ID" value="XM_003848069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNX3"/>
    <dbReference type="STRING" id="336722.F9XNX3"/>
    <dbReference type="GeneID" id="13401942"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50246"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_1"/>
    <dbReference type="InParanoid" id="F9XNX3"/>
    <dbReference type="OMA" id="KASHRTI"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="234" mass="24643" checksum="083122726E17224D" modified="2011-10-19" version="1" fragment="single">DDSLLRDRISCKRALESYNDACTARSMASPAEQSRLFGTILHPSARSGSGEIGSDGWNGGAAGGVGRMNGPQGSSGRRSVVLAPFRCELGYNIHLGDNVVVDNGCYFQDAAEIYLGNGVIVGADCKFYTLEDLSASSRQEGPQGLFRAGAIRLEDHCVVGGNVTILPFRTIGKGARVVAGSVVTRDVRPGTVVAGNPAQEVRSEEKKGVEEENARMLEGMQSGFRGRGGGYGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ41</accession>
    <name>F9XQ41_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847599.1">
        <property type="nucleotide sequence ID" value="XM_003847551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ41"/>
    <dbReference type="GeneID" id="13401015"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97404"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.213"/>
    <dbReference type="eggNOG" id="ENOG502R8WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054505_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ41"/>
    <dbReference type="OMA" id="DVEESTW"/>
    <dbReference type="OrthoDB" id="3861992at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="30071" checksum="1490176D161AD70F" modified="2011-10-19" version="1">MAPLFPRVTGDHHPDAELYQMRYALNQAASICDEFFANEPVRTKDDPRLPRAQRSDALPDIPPRPTSLTDHPANAQHQKMRQDLYREEARIATAIRNHFSERINNPNTPEPTEGLLGNDMQKSMQQGPELTTEDYAVISKGFQDRLKRDVDRFATSNGLLGADWRAHTGGLHEECVEIMVDFYLEYGPPNVAETLMLAELLRYPTNAVTWFFARIVQNAADARRGEKLVANKVFQLRLKEYGMLEAMQTYTRNQAAAQHIADMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ78</accession>
    <name>F9XQ78_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgFAE3</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_51439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847726.1">
        <property type="nucleotide sequence ID" value="XM_003847678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ78"/>
    <dbReference type="GeneID" id="13401020"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51439"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="InParanoid" id="F9XQ78"/>
    <dbReference type="OMA" id="LFNIETW"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130645" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="533" mass="57906" checksum="821712F516C5439E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM3</accession>
    <name>F9XQM3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847487.1">
        <property type="nucleotide sequence ID" value="XM_003847439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQM3"/>
    <dbReference type="GeneID" id="13400548"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97564"/>
    <dbReference type="HOGENOM" id="CLU_734056_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQM3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="377" mass="40981" checksum="FBB52A21529CCE4A" modified="2011-10-19" version="1">MALGRVAWEVISGLGALDGVSWAEFSAIKDLKSQVACASHQRRMMEGIDGLPRGSDETFFHMVALPMIAAVRSCSDEAARSVKDFSTEEVYAALSVLPAPPPLSLPEQTMIVNLNIRNASIFGRWPAMPHFGTSDFDSNTQFSFNSGFDSNTQFSFNSGFDSNPGFDSNPGFDTMDRGFDTEPPNICATALDSPRLNKEIKSSPDHIDSSEVSRIYEEPRDETSSTGGDLAHLYASGGCCLSEHGYRSACSCIVCSPDQVDLNNIDCQSHPPTSRETDGRFRAAGSVFASGTMGEEIVEPLQLANDVLDAAMHDNFLTSPSDLCTQQRHITKNGEPPADADLDNIDEQALWDEFMIEDSGEDEIAVRGGDEQRAHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRM4</accession>
    <name>F9XRM4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847127.1">
        <property type="nucleotide sequence ID" value="XM_003847079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRM4"/>
    <dbReference type="GeneID" id="13399437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97869"/>
    <dbReference type="HOGENOM" id="CLU_987688_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRM4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="30406" checksum="9F156EE27E016D52" modified="2011-10-19" version="1">MLDVKTKDRCTGSSPVLPNVALPALPATSAAPAIAPRPPFLVSVNTTITGARKPRTLRSRQCTLSQPLRTPEACVAEVDTDGVAPNMSSGIRFNVPLAATTAQYKEVDHRSRPTMCLLRRVPGGTSMVLVSGFSFSSDLYSELIESMKCVDVECPIYRSTSWIGCMPFRGQHYSVLGCHFKDWQQRVEANTAMAGSMPTDIVERVLQCNEDANRGKKKVVPALTQPPTQALPTPMNPYAGWPMPPWAPPPYQAALHQAALQPPTLPLAAVATARGSSPLTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRN9</accession>
    <name>F9XRN9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847091.1">
        <property type="nucleotide sequence ID" value="XM_003847043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRN9"/>
    <dbReference type="GeneID" id="13399444"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97883"/>
    <dbReference type="HOGENOM" id="CLU_1230768_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRN9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="225" mass="25446" checksum="02323BB6296323BB" modified="2011-10-19" version="1">MNPILNRTGNARRDVEVRRRRRTSQCRSTHDRGMAWTDRGTRCGVCGQNCDDEEDVVVIVVEFRRCLSQAAKRAVEDTLNDRKHYPKPVPAHTERRTEERMKGTPSREGQASQQEITKEDKHEHLEGDKASIFVIPKRRYRECGTKDIAPVKIALHHSRPAKRRHASSLTCASKEDVKSVVKAGLVDVKFVGRKRRSGCFLMMGIPGVEVEDEVANVALGFPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRY7</accession>
    <name>F9XRY7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <end position="208"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="460" mass="50153" checksum="D71EC6636F7B6173" modified="2011-10-19" version="1">MATVKPSHDDHERLNRAPVTRLYPSTSGPLAPRSSNNTSAFTRIRTRPSHRPPANMRDEADPGQSRSASSRFVKTFQEKLGHEGEDDDEEEEEEEDDEVDYDNESGDGEDDEEDQSDGTDETEEGDNVDTFESLPTVKPFRALKRNATGISKELASAHERIKNLETGLRGYKIGLDARLDSLAHKQSSRPHRQHRPPTRRDASSPPLPLEDTAFEVQYFLWLSREEKDHCMQLNICFRSRYSSIVANSSGIFNNSDCSVVSTTSSDNFSLCSETSPLSRLADRSHDYAEGSARFAGFFVHYAGTTAYLPQKVLPSKSSLFDAMFPPAPPLPIVASPSVALPATNTPTPSSAPAVVALPSVTPSTSSSLFHAGLESCVPTRHLLPASSPAAPSIQPVAVLPNVALVAPTIVSPTAALPSRQRTNAQQLQALAADMDSNNDTAISCRPRQVMPRGFTPSWTR</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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                <person name="Schouten H.J."/>
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                <person name="Waalwijk C."/>
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                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <comment type="cofactor">
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            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="QFFGQHY"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
    </dbReference>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
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    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="255" mass="28217" checksum="963836FD2C7D3336" modified="2011-10-19" version="1">MAPKVKTSKPGLATAKQPTPNWPAMQPLLPSSDLSFEILLQNQILTIPRLWTSTLAKKYVTFLSTLPLVTTPGKPKRGDAVRVNDRYQIDDAIFAEQLWSCTALKDLVLNAENAEDGTPLSEAAKHELWGGEVLGLNSNIRIYRYSKGQFFDQHYDDANNVMFPSEASPQSIKGRTTWTLLLYLSSPATGCIGGETIFYPEPASKREAAPSPVIAELEVGTALLHRHGKDCMLHEGREVTAGEKWVIRSDLVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWT4</accession>
    <name>F9WWT4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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            <end position="202"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91480.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="210" mass="22136" checksum="4EA016F944C4F955" modified="2011-10-19" version="1">MIDRYTSVANSDRLSSFNLAPGPHNTTQAVPPSPTASLKTNPSVSNPLANIENPILRTGTGEHINPGSIPQPHAYRPNAQAARMPNSASQVDLASAQQDGTPQPLARVTTLRDARTPNNLVTSPTAYDASHSTAFPDMQNSEFSSGLIHGHEPRLFPGIMSSSGGRRRKSSIVRATDDEALAQSTGSLARSGTDEKTIREGVAEGSAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 115943 / IPO323</strain>
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    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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    </evidence>
    <sequence length="690" mass="75259" checksum="23604284F692DD45" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="368" mass="41992" checksum="70F5A4982ED109B8" modified="2011-10-19" version="1">MAATGLSAGLAWVLPVRPDKLGPHLKNFEEAVPTLHALRLCHRYGRGADVHITKLPAELELLIEGFIIHPFKCSTEWGRIARWEDDFKCFESRCSPLFHLAGASSLDCIYDDFTFCGSVACEPYGGSNEDCRTLCKNSETDPCEVCKTRSSEGVCEKSCHGRELEESESFLSECAVWIDLHFESRHEWDERVCKTEVDKMNATLRKHFGLEVTFTETRTYVPERDNWPMHKNYKWHDENHIQTTICHLTMPRPKPPAHEWLSSDMEDSTGSFCIEGTQTLAVNMESHISNAAIKQRFQKATNYLRLEPSPHTSQHYSELRPTLEPHATSSDTATDPNEKNEKAIQDEPKLEWPKLVLMLSTWSSGHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXD3</accession>
    <name>F9WXD3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_83301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855838.1">
        <property type="nucleotide sequence ID" value="XM_003855790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXD3"/>
    <dbReference type="STRING" id="336722.F9WXD3"/>
    <dbReference type="GeneID" id="13403806"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83301"/>
    <dbReference type="eggNOG" id="ENOG502SK2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_0_1_1"/>
    <dbReference type="InParanoid" id="F9WXD3"/>
    <dbReference type="OMA" id="TQDWISI"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="32"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="210" mass="22996" checksum="331FD04D23D5CCF4" modified="2011-10-19" version="1">MPENLKQSEVDAQTDPSVAKQYDNESSAEEKFKDLYAIADGIKIGMLSTYRQGTGPVSRAMAVSKRSGPDFLFLANKHSNKISDLQSNKEVNLTFHDKSNQDWVSVTGEAVKTSGDDPRIKEIYSKVVSAWFGDLGDGVHNGGPEDPRMYLVEVRSKYISYYKHTSGMLGQAKEIGGAVLTGKVAQTGVLRELKEADIEQARKSDSALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXF8</accession>
    <name>F9WXF8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_88680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857763.1">
        <property type="nucleotide sequence ID" value="XM_003857715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13403820"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88680"/>
    <dbReference type="eggNOG" id="ENOG502SJP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003334_1_0_1"/>
    <dbReference type="InParanoid" id="F9WXF8"/>
    <dbReference type="OMA" id="AVWWFLR"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="752"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1215"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1392" mass="150911" checksum="FFEE3B2646139230" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY06</accession>
    <name>F9WY06_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_65997</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856256.1">
        <property type="nucleotide sequence ID" value="XM_003856208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY06"/>
    <dbReference type="FunCoup" id="F9WY06">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY06"/>
    <dbReference type="GeneID" id="13394661"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65997"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.904"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="F9WY06"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="221"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP91232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="314" mass="34085" checksum="B8EA761CEC64337B" modified="2011-10-19" version="1">MSGQQQDKSFMGMPGFVVDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKSGRLSHKYEGIGDCFKRTTADEGVAALWRGNTANVLRYFPTQALNFAFRDTFKSMFGYKKERDGYAWWMVGNLASGGMAGATSLLFVYSLDYARTRLANDAKSAKKGGDGQRQFNGLLDVYKKTLASDGILGLYRGFGPSVAGIVVYRGLYFGMYDSLKPVLLTGNLEGNFLASFLLGWTVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSFDAASQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQMQLLMFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYL1</accession>
    <name>F9WYL1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MgSsk2</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_67344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856959.1">
        <property type="nucleotide sequence ID" value="XM_003856911.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WYL1">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYL1"/>
    <dbReference type="GeneID" id="13398670"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67344"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="InParanoid" id="F9WYL1"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1336"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1346"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="1346"/>
            <end position="1360"/>
        </location>
    </feature>
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        <location>
            <begin position="1376"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1093"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP91935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153948" checksum="A1A7CB74B3F955DD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYY9</accession>
    <name>F9WYY9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NTC1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_65376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
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            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
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        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857561.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9WYY9">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9WYY9"/>
    <dbReference type="GeneID" id="13403180"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65376"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
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    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:alpha,alpha-trehalase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
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        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="8">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="886" mass="100859" checksum="85AE04BB113F9C37" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZA3</accession>
    <name>F9WZA3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="6">Transcription initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GTE2401</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_107338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857263.1">
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    </dbReference>
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    <dbReference type="FunCoup" id="F9WZA3">
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107338"/>
    <dbReference type="InParanoid" id="F9WZA3"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Csukai M."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
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    </dbReference>
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        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="AMINEOXDASEF"/>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="154"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="603" mass="65646" checksum="C34700064200FCE8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZT5</accession>
    <name>F9WZT5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 20">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 20">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MYCGRDRAFT_98287</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 20"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856053.1">
        <property type="nucleotide sequence ID" value="XM_003856005.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WZT5">
        <property type="interactions" value="1141"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZT5"/>
    <dbReference type="GeneID" id="13394306"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98287"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="InParanoid" id="F9WZT5"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15 19 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 19 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 19 20" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="23">
        <location>
            <begin position="548"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="24">
        <location>
            <begin position="800"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1268"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1354"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="1116"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1270"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1510"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1541"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1567"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1637"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1657"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="19">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGP91029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1677" mass="187351" checksum="840CBF7658FB9E2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZX9</accession>
    <name>F9WZX9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_98377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856159.1">
        <property type="nucleotide sequence ID" value="XM_003856111.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9WZX9"/>
    <dbReference type="GeneID" id="13403065"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98377"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.703"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026967_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZX9"/>
    <dbReference type="OMA" id="ISKKCHA"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="15">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="14">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP91135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="421" mass="46851" checksum="ACAF49E98A5E7F97" modified="2011-10-19" version="1">MSTQLESVYRLKCSCNQYPWGRQGKESIAARLCESQPGWDGHGPKTQFKIDESKPYAEMWFGTYPTLPSYVADTGEDLQDVLDRHPKELIGDEVLQKFGHSKLPYLPKVLSISKALPLQLHPNKDLASKLHKEDPESFTDPNHKPEIAIALGKFEAFCGFKPLADIAKLLKLEPLQEFVDQDQLSNFSNSQLKEVVRKMLKAEESTVKKVYKALTSLPESQFGKETHIPQLAPRLAEQYDETDNGILVALITMNYLVLEAGESIYIPADGIHAYLSGDIIECMARSNNVLNTGFCPSADRNSVDLFCSCLTFQPHSKDDCMLRPQKYNRSKNGKTVVYAPPLSEFDMLQTDLKSGEKEVPGAVGGPSVFIATKGNATMKAAGKSYDVNEGSIFFVAQGTELEFESKDDFTMHTAFVEGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X056</accession>
    <name>F9X056_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_23234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857353.1">
        <property type="nucleotide sequence ID" value="XM_003857305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X056"/>
    <dbReference type="GeneID" id="13402924"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23234"/>
    <dbReference type="eggNOG" id="ENOG502SH5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_0_2_1"/>
    <dbReference type="InParanoid" id="F9X056"/>
    <dbReference type="OMA" id="HFFYCRI"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="517" mass="57578" checksum="F9F384114D8F7D7E" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0K2</accession>
    <name>F9X0K2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_67205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856662.1">
        <property type="nucleotide sequence ID" value="XM_003856614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0K2"/>
    <dbReference type="FunCoup" id="F9X0K2">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0K2"/>
    <dbReference type="GeneID" id="13398068"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67205"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1737"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_1_3_1"/>
    <dbReference type="InParanoid" id="F9X0K2"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="208" mass="23215" checksum="3F2748AFAA716A10" modified="2011-10-19" version="1">MAQLQKPFEQKNASTLYYVISIVLGTVALSYGSVPLYKTICQQTGWGGQPIKSAAHSVPDGEDEVTAKLTPVTSSRRLRITFAGSTSDILPWKFTPQQREVRVLPGETALAFYTATNQSKDEDIIGVATYSVTPAQVAPYFSKIQCFCFEEQRLNKGETVDMPVFFYIDPDFLKDPTMRGIDTITLNYTFFKAKYDKNGHLSPVPSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Q1</accession>
    <name>F9X0Q1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856942.1">
        <property type="nucleotide sequence ID" value="XM_003856894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Q1"/>
    <dbReference type="GeneID" id="13398225"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90148"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1915"/>
    <dbReference type="eggNOG" id="ENOG502S7U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587958_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0Q1"/>
    <dbReference type="OMA" id="THERGHW"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="476" mass="51375" checksum="FA26C663467C09C7" modified="2011-10-19" version="1">MPADARLLVHAGASTSWKGDDQSRSQLAAYLKIGATHVARRLPMILPESGSDGDDNHDRHEAMSDIDSAGHPDSTTWIDDTQLAYTALESQLYTGFSEPEVSAFVGRRSASAAAYPRSQMSDHVRSGQDVQPRSQNSEQLSAGDDERLSKRPRLEQYHASVGSWTGSSKNASPAHDGHTGQMFGDAGESAGDTAISNETTSELPTTYTLSDLASHGLNARPLLTQRSASDPGPTPINREGALDSLRSIEVSPSKPVPDIFAPKEALETVAPAQLFAKVVPPKDPKLFLNASRLQTVEEMQMLSNAIRPSQPTTSLARYTTHMSPALQHLANDPGLSSAFRPVSSSRAIDPLERGHWLVECAEWPPELQVKFWKTLETIIGEGNAGWGVWCSRGREAPITMASQLPTSVQPDDAAQFGPVRVFCWGEVVKHVYLLLYVASSSKVRKLGLQWVDAEDLVVVQMQGTAGSAAPVHRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0U6</accession>
    <name>F9X0U6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_52717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857471.1">
        <property type="nucleotide sequence ID" value="XM_003857423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0U6"/>
    <dbReference type="FunCoup" id="F9X0U6">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0U6"/>
    <dbReference type="GeneID" id="13403042"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52717"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.754"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0U6"/>
    <dbReference type="OMA" id="FRQNFYQ"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="178" mass="19591" checksum="10A5030288B0C75D" modified="2011-10-19" version="1">MSARFGLRAAQTTFRQPVFQQNVNAHLRFAQRRMQSTVTEAAEAAKATESGLARFLNSPVGPKTVHFWAPIMKWGLVLAGAADFARPADQLSLSQNTALMCTGLIWTRWCFVIKPRNLFLASVNFLLFCVGATQTGRVLSYQASQKGTTVGEEIKDAAKEQGKKIEQAVEKVEAKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X110</accession>
    <name>F9X110_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_89454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856329.1">
        <property type="nucleotide sequence ID" value="XM_003856281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X110"/>
    <dbReference type="FunCoup" id="F9X110">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X110"/>
    <dbReference type="GeneID" id="13394810"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89454"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1042"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_0_1"/>
    <dbReference type="InParanoid" id="F9X110"/>
    <dbReference type="OMA" id="TVELKYW"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
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        </location>
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            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29494" checksum="D9BC1E7009DEBDE3" modified="2011-10-19" version="1">MRPRTLRAATNAITSSVRRDRPTPRRPYICDNCRQQLSSPSQTRFLSTTQRRAFNITPSLRQQQSRAQQHEAASETSARPTQTHYSLFPSTFPAGPPPASPFTPSLPALRREFLTLQQKSHPDLFPPAEKPRAEALSMLINEAYRTLQDPLRRAEYLLSLQGVDLDDESAKLGDQAAGEGGELLMEVMEAREAVDEVEDEAGLEALKSDNEERMKGSVAGLEAAFAEGNLEAARREAVRLRYWKNIEESIRGWEKGHGGGNNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1T6</accession>
    <name>F9X1T6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855117.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1T6"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91063"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.964"/>
    <dbReference type="HOGENOM" id="CLU_438195_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1T6"/>
    <dbReference type="OrthoDB" id="10285075at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395474" evidence="2">
        <location>
            <begin position="23"/>
            <end position="624"/>
        </location>
    </feature>
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            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="624" mass="67196" checksum="C2AD0BD8F1BFCFAB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Y7</accession>
    <name>F9X1Y7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1Y7"/>
    <dbReference type="OMA" id="IQGMVKR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24370" checksum="975E477950B191C1" modified="2011-10-19" version="1" fragment="single">LQDSINQIILDPRYHEPLVLVKAVRNGLVYGTKIRFPHALVLVSLFGSGTTQQKIKKILQLTRDHAFVLAKFAFFYKLICMVLKRANRGKEQAVHSFVAGLSCGYWVFGRSAVASSSVVQQMVMYAMGRVMMGLARLVVQAPGEKSATIATHEGRDWRGSLLRAGWPVSASLCWGVVMWLFTWHPEVLQPTLRNSLTDIYVNSEKWDGLGTLLLRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9X245</accession>
    <name>F9X245_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855708.1">
        <property type="nucleotide sequence ID" value="XM_003855660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X245"/>
    <dbReference type="GeneID" id="13403648"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103102"/>
    <dbReference type="HOGENOM" id="CLU_2628791_0_0_1"/>
    <dbReference type="InParanoid" id="F9X245"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="78" mass="8986" checksum="C6A59E58153D8AEE" modified="2011-10-19" version="1" fragment="single">MPAWSVCDQSAAETLTLKVSLVFRGDSRSYNLLHPPVHQEHPIERFCTPSKIHPRQFSLHAELHKDVDQDKTSQRHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2G0</accession>
    <name>F9X2G0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55 superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_99181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 115943 / IPO323</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
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    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="127" mass="13818" checksum="889C13131D976702" modified="2011-10-19" version="1">MAGLKTIIVLSFILAIGFLLVILSSALFKNYLPLLVVATYVIAPIPNWVCGKAQGSDDFMDNGNNSIVELGRFLTGFLVVMGIALPVVLAHCDLIQIPAMAMSIVGGLLIYSTIISFTMFFREQEEF</sequence>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <sequence length="136" mass="13300" checksum="53A82937F0DB0C5E" modified="2011-10-19" version="1">MKYSAILLASGLTAAYALPTAQPATDLAVEKRTLGLLHKVLGSLGQYGHGSIPSSYGGSKPSGYSPPSSYSHGSSPPSSYGVPSGYGSGGGSSHGVPSGYGSNGGSSHSSGCPGCNGGGLPPTNGPFLRSANLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J5</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Dehal P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="EGP90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="58" mass="7033" checksum="62F842BDE6419392" modified="2011-10-19" version="1">MALTKKWLSLRVEQSLKSIQYLGKSAIPFRRPCQQSDRYRHTSYFHWQLLLHDLLDKT</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="50594" checksum="49200F91143D0BDA" modified="2011-10-19" version="1">MAEIEVQSDSDNDTFSDILNDTVNNVIDQVNETVTETFVAFDAYFSNYHNWDDYVDGVTENILEDGFDLTDLLPPTINVSSFDNELDLAIPATTITFRFEDLDLYLELETKLKASATYTLKLMPPGANPVGIELPNNIKFGVIFSVDLILAIDGELDITGGLHVKVDDHVAMRLELFGDKVSDMSLEGGHFELLPVTVQSATASFTATLRLGAKAAMTIGNVIPLTDEIPSPLKDAKVGNLSLSDLQLAGGILMGVNADVAVFKTSFELVPADPDCRFKVVQDYSLALGATAGAQVTVGTVMYGPAVATSTAVYTTTLNSYCVIDAAPTVTSTAEKLKRQATAGEYSTELTTTRLYSAIECPATVTGECPVSLQTTMHQIETTSTTVYAANEYDLPSEYPTAATSMAAITRIPLGTGAQKLERISGSPSAYTPGPTSVSEYVNDAVEAAKKHRSIAIGVGVGLGVPLLVLIGALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3E4</accession>
    <name>F9X3E4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_79213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855756.1">
        <property type="nucleotide sequence ID" value="XM_003855708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3E4"/>
    <dbReference type="GeneID" id="13395945"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79213"/>
    <dbReference type="HOGENOM" id="CLU_3015972_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3E4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="56" mass="5946" checksum="45794AD044031536" modified="2011-10-19" version="1">MDIEYGFFSAMALSKAESAQGACGHLKCHLHRPLARCQPRGQNASEARVAIGSSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3H2</accession>
    <name>F9X3H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_37615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854852.1">
        <property type="nucleotide sequence ID" value="XM_003854804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3H2"/>
    <dbReference type="FunCoup" id="F9X3H2">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3H2"/>
    <dbReference type="GeneID" id="13403598"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37615"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.360"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="InParanoid" id="F9X3H2"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="85"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="445" mass="48526" checksum="87F88E903F0D60BA" modified="2011-10-19" version="1">MADSDGEYDGHGSDDEIATNGGRAMPSRSKGRAQASWEAGATRAWELKEAPDGSIEGVLGGIEEASKRKRLLKDTTPLQRGIIRHTILMLDLSVAMLEKDLRPTRHLLTITYTIAFIREFFEQNPISQLGILGMREGLAIRVSDMSGNPNDHIAAVRALRGTDPKGNPSLQNGLDMARAALYHTPSHGTREVVIILGALLTSDPGDIHDTIKACIKDRIRVTIIGLAAQMHICAEICRKTNAGDDNCYNVAVDEVHFRELLMGITTPPVVRSTDAEAQKLNQAALLMMGFPSRIVEEHATLCACHGNLTRGGYLCSRCKAKVCSLPATCPTCDLTLILSTHLARSYHHLFPLQNWVEVSWQRAADRGSEQCFGCLSPFPRVHGATNGDDADKTYSKRAEGASESSRYECESCQNHFCIDCDCFNHETSHNCPGCTSSTHLPGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X416</accession>
    <name>F9X416_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_108321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855171.1">
        <property type="nucleotide sequence ID" value="XM_003855123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X416"/>
    <dbReference type="STRING" id="336722.F9X416"/>
    <dbReference type="GeneID" id="13400693"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108321"/>
    <dbReference type="eggNOG" id="ENOG502S18W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="InParanoid" id="F9X416"/>
    <dbReference type="OMA" id="CRIWHTP"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062223" evidence="1">
        <location>
            <begin position="16"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="154"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="399"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="608" mass="65322" checksum="FFC84E66BA195FB2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X474</accession>
    <name>F9X474_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_54855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855729.1">
        <property type="nucleotide sequence ID" value="XM_003855681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X474"/>
    <dbReference type="FunCoup" id="F9X474">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X474"/>
    <dbReference type="GeneID" id="13403669"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54855"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_1_1"/>
    <dbReference type="InParanoid" id="F9X474"/>
    <dbReference type="OMA" id="GEWEMQF"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11093" checksum="AA3AEE9A823C9137" modified="2011-10-19" version="1">MPVYLAVRGKIFDVTPGRNFYGPGGPYANFAGRDASRGLACGSFDAEMLTEDLDGPLDKLEDLGGEEMEALQGWEERFNEKYLVVGKLVPVGHAEAEPDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4F1</accession>
    <name>F9X4F1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_68480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854976.1">
        <property type="nucleotide sequence ID" value="XM_003854928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4F1"/>
    <dbReference type="STRING" id="336722.F9X4F1"/>
    <dbReference type="GeneID" id="13403447"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68480"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.662"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_1_2_1"/>
    <dbReference type="InParanoid" id="F9X4F1"/>
    <dbReference type="OMA" id="PFLVCEG"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27424" checksum="7B9E395024AFA974" modified="2011-10-19" version="1">MASAVSNLHSGSNSRFNAEAKSWDARPFVHEASQGAANAIASKLKDAPVPEGGLQILEIGCGTGILSFLMAVHPNVRQIVAVDAADGMIDVLKQKLEKDGAPKNILPLALLLEDPENPQLPNGDNGKKQKFDVITSHLVLHHIPELEPVLRTMYECLKPGGCVMLTDFEDFGPEAKRFHPASKMDGVARHGINAGEMKTKLENVGFNDVEVRPHWSMKKTVEKFDGEFGESGKIEPGAGELMGFPFVVCYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X561</accession>
    <name>F9X561_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_103744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853843.1">
        <property type="nucleotide sequence ID" value="XM_003853795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X561"/>
    <dbReference type="STRING" id="336722.F9X561"/>
    <dbReference type="GeneID" id="13395592"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103744"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.546"/>
    <dbReference type="eggNOG" id="ENOG502SD63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117263_1_0_1"/>
    <dbReference type="InParanoid" id="F9X561"/>
    <dbReference type="OMA" id="HNRINAN"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15519" checksum="78C7AB8A0D4760B0" modified="2011-10-19" version="1">MDSSLRSTEALKSRIDALQVTLTRRFETLVNLAAVQRNDRTVTAVTEYSMKAETAGLIRAAEEVQTLIRQLQEMWLFGRLNALEGKKEREEVDGTAREVAELVRKLTGAKSLDGEKAVKREGGSVDGDHDGEAMELELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5E2</accession>
    <name>F9X5E2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_84945</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853622.1">
        <property type="nucleotide sequence ID" value="XM_003853574.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X5E2">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5E2"/>
    <dbReference type="GeneID" id="13395850"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84945"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="InParanoid" id="F9X5E2"/>
    <dbReference type="OMA" id="SSGYVWR"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071071">
        <property type="term" value="P:regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000013">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="634"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="791"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1171"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="232"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1175"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1202"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1322"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP88598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1474" mass="162950" checksum="A2B14222C01F4255" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5I5</accession>
    <name>F9X5I5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_38901</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854550.1">
        <property type="nucleotide sequence ID" value="XM_003854502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5I5"/>
    <dbReference type="FunCoup" id="F9X5I5">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5I5"/>
    <dbReference type="GeneID" id="13395736"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38901"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.257"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_2_1"/>
    <dbReference type="InParanoid" id="F9X5I5"/>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="85" mass="9509" checksum="6CB6F6FA69023454" modified="2011-10-19" version="1">MSDPKSELMQQVRQQAALQNARQLVDKVNEHCFERCVPKPGTSLSSGETTCYTACMDKYMKGWNIVSQQYLSHIQKGPAAGQSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5X5</accession>
    <name>F9X5X5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854044.1">
        <property type="nucleotide sequence ID" value="XM_003853996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5X5"/>
    <dbReference type="GeneID" id="13404383"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92050"/>
    <dbReference type="HOGENOM" id="CLU_2293925_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5X5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="101" mass="10704" checksum="F58599FE4842E6E5" modified="2011-10-19" version="1">MGEWPVVSELEVFVRELRSVDGLSACTIPAGEITALKHEIRNHTAEAGTGTAEAFLARAEGTEVFDSLGNDVVVQLEIDSSQALPLLVDPVNCGPVQVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9X762</accession>
    <name>F9X762_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_57384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854184.1">
        <property type="nucleotide sequence ID" value="XM_003854136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X762"/>
    <dbReference type="GeneID" id="13404445"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57384"/>
    <dbReference type="eggNOG" id="ENOG502QYWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="InParanoid" id="F9X762"/>
    <dbReference type="OMA" id="FEVGEYM"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="625" mass="70605" checksum="B3E8FDD5085BB7F6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7H7</accession>
    <name>F9X7H7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_70537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854168.1">
        <property type="nucleotide sequence ID" value="XM_003854120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7H7"/>
    <dbReference type="GeneID" id="13404464"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70537"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1099"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048347_3_1_1"/>
    <dbReference type="InParanoid" id="F9X7H7"/>
    <dbReference type="OMA" id="NSLYTIW"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="214"/>
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            <end position="329"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="22"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="36471" checksum="E7CD678EF32F404F" modified="2011-10-19" version="1">MTSFSTLSNDVEPPSMESKDEETALDSALYEDRLPRWRTSSQQRSRFIDALWVGLNASATIAIVFMNKFVFADPQLRKAQIMISMWHFAATFIVLCAASRGSRRLFTPIRLPTLQVLPLSAFFAGFLLLNNLSLATNPVGVYQLAKILTAPAVVWINFILFRKTIERNKILAVLITCTGVGIVSVDALRTNVIGTAIAGAAVTITACYQIWIGKKIVDLGVEAPQLLLNQSATAVCLLIPISLCIDTFPDFSIIPANTLRFLFAGGIVASFINLSQFMIIGRTSALTFNIVSNIKMLSILSLGWYSEGRIFTLVDVVGILLAFSGAWWYTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7N3</accession>
    <name>F9X7N3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Imitation switch Two complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NFE2401</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_85041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="eggNOG" id="KOG1245">
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    </dbReference>
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    <dbReference type="InParanoid" id="F9X7N3"/>
    <dbReference type="OMA" id="FVEVHCA"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
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        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
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        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="5">
        <location>
            <begin position="346"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="297"/>
        </location>
    </feature>
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            <end position="448"/>
        </location>
    </feature>
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        <location>
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            <end position="680"/>
        </location>
    </feature>
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        <location>
            <begin position="917"/>
            <end position="955"/>
        </location>
    </feature>
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        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
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            <end position="680"/>
        </location>
    </feature>
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        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="955" mass="109721" checksum="C19FCCFB71B00478" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Q0</accession>
    <name>F9X7Q0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="7">Beta-Fructufuranosidase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">MgSUC1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_38524</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13404043"/>
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    <dbReference type="eggNOG" id="KOG0228">
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    <dbReference type="Proteomes" id="UP000008062">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
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    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="406"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="591" mass="65478" checksum="B5418B3BC415CEB1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7W8</accession>
    <name>F9X7W8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two-component response regulator SSK1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgSsk1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_70181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7W8"/>
    <dbReference type="STRING" id="336722.F9X7W8"/>
    <dbReference type="GeneID" id="13404311"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70181"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008307_4_1_1"/>
    <dbReference type="InParanoid" id="F9X7W8"/>
    <dbReference type="OMA" id="QALIDWN"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="PHI-base" id="PHI:7445"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="328"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="589" mass="65131" checksum="754ED97E23BB53C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9X865</accession>
    <name>F9X865_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_41102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852831.1">
        <property type="nucleotide sequence ID" value="XM_003852783.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X865">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X865"/>
    <dbReference type="GeneID" id="13400849"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41102"/>
    <dbReference type="eggNOG" id="KOG0230">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_0_0_1"/>
    <dbReference type="InParanoid" id="F9X865"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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        <source>
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</entry>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
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                <person name="Canto-Canche B."/>
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                <person name="Dehal P."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
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        </source>
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        </source>
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    <sequence length="775" mass="83897" checksum="C78E0C97B786315F" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="38115" checksum="61FBBD1ECEB5654A" modified="2011-10-19" version="1">MWFTAVSTLQRAFTSHHEKRKVRDKLGDWSLLQYRSRFRFFRARPYLLKSILPPAMSFTFIRKQVQAKLKKSLYHPCQIRDFMEMRWTLLLLITLFRTMAAERVTDKDTWVRRILETAGTEATDGAVRVRTGRIVADIVATSQWGLQRTTSTELHDVDLTIDAIFAGVVQWTREVNRLLDQKVSLADQKKYNVEEACSSSEEEEESDNEPIENYEPSDKENQSPTSNNSNSPHSRNKNKNSKDKKTPNICYWTREETIALLKQYRDAPLDVHGRPATHQQVADWHNEDWFPDGAHKRTKVALQQQLKALVRSDRTLIPAKIKELEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4 5">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853337.1">
        <property type="nucleotide sequence ID" value="XM_003853289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9P6"/>
    <dbReference type="GeneID" id="13400005"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92695"/>
    <dbReference type="eggNOG" id="ENOG502SR4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880570_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9P6"/>
    <dbReference type="OrthoDB" id="3649716at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="36239" checksum="98872CA52D9CCDA5" modified="2011-10-19" version="1">MFSQYMSQEDAQVETKASQRRWRFNDPLLAGRNPDKSLGRIVIRIWIICFAIWGLIDVFVHQLPPALTKIFDSKPADDCWCGETDQQAVAMGCQYDHLAVDWLPPSCIDQALVDEFDMSGPGVDGAWIYYDPRVSEDGMSTLFVSISTNETDEFALRGKQYFATRGWHILHCMFTWRKQFRAWHSHKPIEPWNDDEEHIKHCSEYIMRTLEWHLSLDVIDTQILGGDRHRERQEKGNRDAATETQSVEEVPDYGGDAKKGRPENNVPPSVQVNPLFRIMRTGAQVLLEDMKSSDNGEPQQPNASRPPPFPYRGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAH2</accession>
    <name>F9XAH2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_71676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852015.1">
        <property type="nucleotide sequence ID" value="XM_003851967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAH2"/>
    <dbReference type="STRING" id="336722.F9XAH2"/>
    <dbReference type="GeneID" id="13393805"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71676"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.7"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAH2"/>
    <dbReference type="OMA" id="IYLYWLT"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="391" mass="43880" checksum="A2089708CBD29380" modified="2011-10-19" version="1">MAPFSGVLEVKPFKAAVSDSALEDFKQLLRLSKVGPATLENSSQADSAYGLSRDWTEKAKDYWLNKYDWRKTEERINSFENYKATITGEDGENLDIHFLALRSSKPDAVPVVLLHGWPGSVLEFLGMLDLARNKYKSEDLPYTFIVPSLPGYAYSSGPSMKSESTCETMAYFVDKLMVGLGFGSGYIAQGGDIGSFVSRILGAQYESCKAVHVNFNIMQPPEGEASKDITAMEMKGLERAGQFNEQGSSYAMEHGQRPATIGLVLSTSPLALLIWIGEKYLEWVDDHLSLDHILDSVSLYWFTDSFPRAIYPYRQFFGPKPKAITKAYYIGKPMGYSWFPREIAPMPLGWVRTTGNLVWHKSHEKGGHFAALERPQDLLDDVEEFVKAVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAV4</accession>
    <name>F9XAV4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">MYCGRDRAFT_71826</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852730.1">
        <property type="nucleotide sequence ID" value="XM_003852682.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XAV4">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAV4"/>
    <dbReference type="GeneID" id="13393864"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71826"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAV4"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1137"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1286"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1326"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1106"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1396"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1439"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1478"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1528"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="949"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="950"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1060"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1080"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1083"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGP87706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1543" mass="175265" checksum="08D1A991F8944F06" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB29</accession>
    <name>F9XB29_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_42169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852440.1">
        <property type="nucleotide sequence ID" value="XM_003852392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB29"/>
    <dbReference type="FunCoup" id="F9XB29">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB29"/>
    <dbReference type="GeneID" id="13394149"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42169"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB29"/>
    <dbReference type="OMA" id="SERCMPK"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="487" mass="52986" checksum="B7752BB6706BBC7A" modified="2011-10-19" version="1">MQHPFQCIASLRVGPGEQDGYLITACGPRLVVLKLATSEVVCEWSAEETPVEPESKQDDTAERPAKKQKTSNASPENDTPLTGKRQKSNKAPPKASNIIKLTVSPSQSHIVAVTDDKSIRVFSFDSSSKTLTELSRRCMPKRPCAIQVLPDNATLICGDKFGDVYSLPLLPSSEPEVNAPQSEAPPATEQFKPSATPLTVHSRRNLAALTQQQKQKNFTPRKDTLSAFSNTLLLGHVSMLTDMLYTTHQSAGESKPRSYVLTADRDEHIRISRGPPQTHVIEGYCLGHTAFINKICRVGTSEVLVSGGGDSWLGVWDWLNFSLRQKFDLLSLVQNISPEETQIAVSGIWSVGDGESASVVVTCEKIKALFIIPRTALESGSDEGVQTIPLSHCPLDVVVTDDAILVSTDARAEGEKRVICGKLGESGWEECSEKELEAANAYKGPERLITDKEMDAFLYNVANLRKRGPLEEGAAEEAEADGGAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBG9</accession>
    <name>F9XBG9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_104607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852529.1">
        <property type="nucleotide sequence ID" value="XM_003852481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBG9"/>
    <dbReference type="GeneID" id="13394054"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104607"/>
    <dbReference type="HOGENOM" id="CLU_2656363_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBG9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="76" mass="8418" checksum="70CDDBF1BBB23D37" modified="2011-10-19" version="1">MSRGGSVNTLVIRPSNLRKDWEPFAPIRSSTAVLITVLVLHTLPPGFTQSKASDDRILVRSFCRSTFSRGNFSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBL6</accession>
    <name>F9XBL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FUM1</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_100165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852692.1">
        <property type="nucleotide sequence ID" value="XM_003852644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBL6"/>
    <dbReference type="FunCoup" id="F9XBL6">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBL6"/>
    <dbReference type="GeneID" id="13397014"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100165"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="InParanoid" id="F9XBL6"/>
    <dbReference type="OMA" id="AKWRAQT"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="7">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="531" mass="57187" checksum="F0C662B35B8D28C6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCK8</accession>
    <name>F9XCK8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_72208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852599.1">
        <property type="nucleotide sequence ID" value="XM_003852551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCK8"/>
    <dbReference type="STRING" id="336722.F9XCK8"/>
    <dbReference type="GeneID" id="13396921"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72208"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_1"/>
    <dbReference type="InParanoid" id="F9XCK8"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="44764" checksum="432A317097883728" modified="2011-10-19" version="1">MLARSLPSALTFDLVAKCSTTKARAATLNLPHGPVQLPLFMPVATQASLKGLTPIQLEETSCRLCLNNTYHLGLKPGQQTLDAIGGAHKLQSWKHNILTDSGGFQMVSLLQLAKVTEEGVRFLSPHDGTPMLLTPEHSISLQNSIGSDIMMQLDDVIATTSPDHARIKEAMHRSVRWLDRCIAAHKNPTTQNLFCIIQGGLDLDLRRECCEAMVARDTPGIAIGGLSGGEAKSEFCKVVDTCTSLFPERKPRYVMGVGYPEDILVCVALGADMFDCVWPTRTARFGNAVTGEGVLNLKHVRYAYDFGPVEEGCPCICCRSEEQGGLGITRAYIYHTAAKETVGAHLLSIHNVHYLLNLMKRAREAIIADKYPAFLKSYFKKLHSGEKDKYPEWAVDALRGVGVDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDB5</accession>
    <name>F9XDB5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDB5"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93875"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.328"/>
    <dbReference type="HOGENOM" id="CLU_1397341_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDB5"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="21754" checksum="1C9BFC8B10A3C15E" modified="2011-10-19" version="1">MPSEMAARSAPHSTYDPLPPTYKQDQLLLAKQTSTTIMSEEAMIEHRTDASGRFTDKTYLPIYDPDTLAKHTTKDDNPDKVLFFRSLSTAAQGSEHKITIISCGLLVISWIISHQLTKIVARWAVLEPENYTDTLATLKIWNIVCGLVLLQTAIPKFLQWVTPAFHVANALLVPFMQAAFMLMACKAFAVEMGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDC4</accession>
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        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_73114</name>
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    <organism evidence="7 8">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851799.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XDC4">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDC4"/>
    <dbReference type="GeneID" id="13393624"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73114"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.337"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDC4"/>
    <dbReference type="OMA" id="TDCNVML"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="249"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="570"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="779"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1371" mass="148999" checksum="780AF3B4DA7B65D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDH9</accession>
    <name>F9XDH9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_60039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86797.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="210" mass="24119" checksum="BBB1B9C268BDFB27" modified="2011-10-19" version="1" fragment="single">MRLLNVHTLAFHSFHSASTPRYAIASHRWVAGTEAAIKDVEKQRNTESLGYQKVLRFLRYVREHVPGVEWLWIDTCCIDQKSSQEVSEAVNSMLKYYSRAAVCLAYLRDVSHCSLEAFETSEWFTRGWTLQELLAPSLVIFLSNDWNSKTLSLEQKFTWMEGRTTTREEDMSYCLFGIFEIAIGSNYGEGLENARKRLLKAVTEAAAEKS</sequence>
</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="FunCoup" id="F9XDK6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="13402174"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22198"/>
    <dbReference type="eggNOG" id="ENOG502RJPB">
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    <dbReference type="OMA" id="FWPGDIA"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
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    </dbReference>
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        <location>
            <position position="454"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52260" checksum="0E26EBE12A481A1D" modified="2011-10-19" version="1" fragment="single">EEVQSNAEWVNSGKYWLDRQACRWFGLCGTMHMLNKDAWTWTKAEADDPDNRDISDWWTSGSDDPEKWTKEEIKLRKIPQYVLDHAPYVHLFSGEQFWPGDLSEHLIHTTPFLNYSRISDLDEERNLTNLHELNDYAEGKHSRFMYLGALDNVEERPKWLVGGKNIPKMPAQNDGDLDLDYPWPDPNDDLKDFDLEAAKQQTLDDFYHKEGISTKGEVPAEHLPSDRTARPHPDLRRRDHDPTLDNPSHKPQPGGKSSAPAILIVVPKPDGVVDAFWFFFYSFNLGQTVLNIRFGNHVGDWEHTTVRFVNGKPTQIFLSEHNFGQALTYSAVENRAKRPVVYSALGSHAMYATPGLHPYILPFGLLHDETDRGPLWDPVQNFQAYTYNPLTRTVRSSTLNPTSPTQWFDFAGHWGDKFYELGDPRQYRFAGQYHYVNGPTGPKFKNLGRRAVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDV3</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000008062">
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        <location>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="87" mass="9819" checksum="D56B82A0A2021DB0" modified="2011-10-19" version="1">MEMTEAPSCSGIDETPFGARSAPRRLAEPVPRLGSPFMETPPPSRQHNTFPRSTLLPTTMNHEPFHQRLVELVAEHQSTKGQQQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94291"/>
    <dbReference type="HOGENOM" id="CLU_1856873_0_0_1"/>
    <dbReference type="InParanoid" id="F9XER6"/>
    <dbReference type="OrthoDB" id="10412660at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="16635" checksum="CF254DD0BE706D2E" modified="2011-10-19" version="1">MPPRNEASYIRTRAELQYLIDDQVNTSQRQLVRRIDIVLAKLREPGLTKEYRALGARTLRSLYEDLEYANERIVALRAELVERERAVAEFEERERRERRDHEERVRRQRVAEEREVELRRRRRVEAEHAAATRRAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEX0</accession>
    <name>F9XEX0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850872.1">
        <property type="nucleotide sequence ID" value="XM_003850824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEX0"/>
    <dbReference type="GeneID" id="13397610"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94753"/>
    <dbReference type="HOGENOM" id="CLU_2075024_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEX0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="13259" checksum="621B2C78AC81CFB7" modified="2011-10-19" version="1">MAPKPVYGPRATPLIVEPDQLELKAGASGRAVKLQGNMAESRRGQAREEYEPELAASHQRWVDLGEEVVDAMTDKFVGEAFDRPKTLPMCVKRLRLHISDSSYGRFGSHKDRLEPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF33</accession>
    <name>F9XF33_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_45640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851230.1">
        <property type="nucleotide sequence ID" value="XM_003851182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF33"/>
    <dbReference type="FunCoup" id="F9XF33">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XF33"/>
    <dbReference type="GeneID" id="13397376"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45640"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.184"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="InParanoid" id="F9XF33"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP86206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="227" mass="26243" checksum="52E7CD2A0B0F8381" modified="2011-10-19" version="1">MSSEKRVFAPGGQDGTNQAAQFTKGALELHQMDANPFQQFDIWFKHANAEKVNHPETVTLSTAHLPSGKVSARTVYLKEMDDNGFVIYSNFGTSRKAADIESNPNAALTFWWQELERQVRVEGPCERLTAEESQIYYDTRARGSRIGAWTSQQSKVLRDREELEQQVRDTEKRFEGQEKIPVPDFWGGLRVKPEMVEFWQGRDSRLHDRFRYTKDEGGKWKIDRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF90</accession>
    <name>F9XF90_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_105101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850638.1">
        <property type="nucleotide sequence ID" value="XM_003850590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF90"/>
    <dbReference type="STRING" id="336722.F9XF90"/>
    <dbReference type="GeneID" id="13397967"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105101"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.187"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="F9XF90"/>
    <dbReference type="OMA" id="ITQNTPN"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="112"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27915" checksum="4D608EEB05138842" modified="2011-10-19" version="1">MPYEPYTDETPADVKNAKGLHLVTQNTPNGQAVQIFLEELKDAYGTEFTTTVIDISTNEQKKDWFLRLDPNGRIPILIDNTQSPPFPVHETSAELFYLLKFADKSDKFGFSSPLERNQCLQWTFFWHGSGAPYQGQVTHFTRAAPEKIPYAIDRFRNETLRVFGVLEIHLSGKYTGEEKEYLAGNGKGRYSIADIKTYPWVKNWERSGFSKEEMAFPHLLKWVDRIAERPAVQRGVGEAYVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFR5</accession>
    <name>F9XFR5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_44746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851164.1">
        <property type="nucleotide sequence ID" value="XM_003851116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFR5"/>
    <dbReference type="GeneID" id="13397438"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44746"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.328"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_2_0_1"/>
    <dbReference type="InParanoid" id="F9XFR5"/>
    <dbReference type="OMA" id="LSFGTWC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="289" mass="30742" checksum="E27F7F0DA1644A5A" modified="2011-10-19" version="1">MSDSPTTPPSSQKPVYAPGHAASHITNHTWRTASNSTPYLLPHLHSLSTHNPHLHFLDVGAGPGTLTASIATHLPSTATIVATDISPSVLSRASAHFTSKGLSNATTRVASVYDLASTFGEQSFDVVHTHQVLVHLTSPLSALQSMLSVCKSGGTLALREADLRMQSIHPSTPALTAFFPILLKYHASTGGSASMGTELVSLAMAAGVPRGNITATMGTWCIAAREDREAWGWAIAARCREGPMRGKAVEEGWAGEEEMDGMARAWDEWVEAEDGVWGLMNGEVIIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG48</accession>
    <name>F9XG48_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851087.1">
        <property type="nucleotide sequence ID" value="XM_003851039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG48"/>
    <dbReference type="GeneID" id="13397494"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105254"/>
    <dbReference type="HOGENOM" id="CLU_2887557_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG48"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="63" mass="6985" checksum="5C84E6FBA2416906" modified="2011-10-19" version="1">MKIHERGSIAVTCQFHRESTTVPAYNETSINALSQAQQASSVDTAVLEPWNKALQVQRTITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGD8</accession>
    <name>F9XGD8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850566.1">
        <property type="nucleotide sequence ID" value="XM_003850518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGD8"/>
    <dbReference type="GeneID" id="13395309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94220"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.27"/>
    <dbReference type="HOGENOM" id="CLU_1807738_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGD8"/>
    <dbReference type="OrthoDB" id="10355213at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="15022" checksum="39059D052080C8BC" modified="2011-10-19" version="1">MASKLWQPIDPTKAAPVPIRRKNTIPGTWLTLTPSTTSSTNITNAEAVSPTLDPQSASSSFLTNDNSTASDGSSRHSSFTSAGNELTSPLKSDVEVSPRHSSFGSTGNEMRLPMKSNVQAGVHGDAAERREANVALGRKAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGR8</accession>
    <name>F9XGR8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850832.1">
        <property type="nucleotide sequence ID" value="XM_003850784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGR8"/>
    <dbReference type="GeneID" id="13397750"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94690"/>
    <dbReference type="HOGENOM" id="CLU_1929250_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGR8"/>
    <dbReference type="OrthoDB" id="10269069at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="131" mass="15905" checksum="9525B163EF4F60BE" modified="2011-10-19" version="1">MDPSRFYNYSRLWMYNQMPESYDDHEYDRVIIPSRGEIFEWSEQTPMHSHNRPGWTLNNDYFPSQRHIYDQGMMQSNDCMGMQGQRFHDQMRGAGYNYDDAHDGYIGRNPDIFDDSDDEAREAYMGYHFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH30</accession>
    <name>F9XH30_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CYP-31.1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_47046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850238.1">
        <property type="nucleotide sequence ID" value="XM_003850190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH30"/>
    <dbReference type="STRING" id="336722.F9XH30"/>
    <dbReference type="GeneID" id="13394443"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47046"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="F9XH30"/>
    <dbReference type="OMA" id="FRIAPWH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="462" mass="52322" checksum="427FC28225840067" modified="2011-10-19" version="1" fragment="single">LGLGLLLRTFRVAKEQRLLHFFNDLVRSTGNWTFEQRLLGISGIDTFEPENVEAVLSTQFEDFDLGERRKVFFALLGDGIFTQDGAAWARTRALLRPAFYQQNTDRMLDEIDGLVGKMLRDVPEGEEVDFQPLFFRLTLETTMSLLFGKRMEGEDEQRKKVEMDDFAAAFDEAQDWLARRGRLGGLYWLIDGPGFRKSCRIVHRFIDAAIEEALRVKDVNEGETEGYSVLGALLPETQDRKVLREQCLNVLLAGRDTTACLLSWTCRLLASHPRTLTTLRQEITQICGTDPSPPSRAQLKRMRYLDAILKEVLRLYSSVPINSRTASRTTTLPTGGGPDRTSPILIRKGQAVAYSPYIMHRREDIFGPDAADFRPERWLENDGRLFAEAGWAYLPFNGGRRVCLGQEFALLEAGSVIVGMVRRWREWKVAGDGEAFPEVGTERQKVTLVVSCAEGCRLEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHV7</accession>
    <name>F9XHV7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_46958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850534.1">
        <property type="nucleotide sequence ID" value="XM_003850486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHV7"/>
    <dbReference type="STRING" id="336722.F9XHV7"/>
    <dbReference type="GeneID" id="13402677"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46958"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037350_1_0_1"/>
    <dbReference type="InParanoid" id="F9XHV7"/>
    <dbReference type="OMA" id="VPHIAHD"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="444" mass="48266" checksum="932B3F765C782655" modified="2011-10-19" version="1">MFTVVKSAGHSTPRLGRLVLPGRQAIDTPHFLANTSRGIVPHITQDTFKRDTDLNGVYVALEDFIERSPKAPVYELPVPVGKSPLRSFTALPQDTLLVLGARRTKPLVSPAANSNTNSSVSICTAVGFQHLNPRDYANASEDLGVDIVVALGDIPYGRALGSKRVIKAEDRSIAWLQSHAKLHKTERSRSRSNGASKLFASLLPLPCSKQEALVDCVAGEVSADVSGLALYSLDTLGDIPGYLSDLPRLDFTAPESPHAVLQHVRAGMDIMIVPFTGAATDAGIALDFTFPETVEKPTTGHTADLATLGIDMWNPTHAVDVSSLRKGCTCYACTNHHRAYVQHLLAAKEMLGWVLLQIHNHHIVDRFFAGIRESIARDTFDQDVFAFERAYESDLPDKTGQGPRMRGYQFKSEGPGEAKKNKPAFSELKAVADSHPEIMVETGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHX7</accession>
    <name>F9XHX7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_27205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850360.1">
        <property type="nucleotide sequence ID" value="XM_003850312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHX7"/>
    <dbReference type="FunCoup" id="F9XHX7">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHX7"/>
    <dbReference type="GeneID" id="13394255"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27205"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="InParanoid" id="F9XHX7"/>
    <dbReference type="OMA" id="YPNITIC"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="279" mass="29868" checksum="308E610F922E3D5F" modified="2011-10-19" version="1" fragment="single">AQGQQTAVAFLGPKASYTHQATLSVFPNSQTHALAPQVSIEDVFAAVQSSTTGTLGVVPFENSSNGSVVFTLDLFVDLHNRYPDLVVDAEIYLPVRHCLLGHQRKQLCSSSPPKSSSTGVPDLSHITKLYSHPQAWGQCKSFLSKHLHGLERQDVSSTSRAAELVAADPSGTSAAIASKIAAELISPLDVLVEGIEDNEGNSTRFFVLRKLSSSPTSTTSDIPSCDAPTNEEDYERHKTLITFTLLQHGSSGALADCLAVFKNHGINLTSINTRPSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIF0</accession>
    <name>F9XIF0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_74471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849924.1">
        <property type="nucleotide sequence ID" value="XM_003849876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIF0"/>
    <dbReference type="GeneID" id="13402718"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74471"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.134"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="F9XIF0"/>
    <dbReference type="OMA" id="WKRTSWI"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="71"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="572" mass="62438" checksum="E4A66A9224299201" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJN7</accession>
    <name>F9XJN7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_75791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849631.1">
        <property type="nucleotide sequence ID" value="XM_003849583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJN7"/>
    <dbReference type="STRING" id="336722.F9XJN7"/>
    <dbReference type="GeneID" id="13402284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75791"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.475"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="F9XJN7"/>
    <dbReference type="OMA" id="CGHGINI"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="427" mass="46893" checksum="5A10370CAD6A0C2E" modified="2011-10-19" version="1">MSTKKPFHVAIVGGGLGGIALAIALKHRNISFTIYEAKQSFTEIGAGINLGPTASQSLRLIEPSLGEKYMKLATPNPPPNEETWMLFRYGAPSGDHKDGDLMFQLKAPGTGNLTFHRQELLQLMATEMGTEHAKFNKKFSSYEQNEDGVTIRFAGGSEETASLLIGCDGIHSRVRTAMFGENNAVSSPHFSHAGLYRKVVPMEQAIEAIGESARVSQIVHGPGGYLITYPVSGGKMMNCGAWQLVPEQWPIDEWLLPGQKSRFEEGFKDWGERSKKILALFDADPALWGSFQHIQQPKSFYDGRVLLIGDGAHGMPPHQGSGAGQAVEDAYVLSEVLSVMQERGPSSEVVKAGMQAFEAVRKPRSAEVHRLSSITGPRFCEVYDQKLEGQELDDWICLTKKRLRSIWSVDMAGEAEKAREELSRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKB2</accession>
    <name>F9XKB2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849407.1">
        <property type="nucleotide sequence ID" value="XM_003849359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKB2"/>
    <dbReference type="GeneID" id="13399103"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95745"/>
    <dbReference type="eggNOG" id="ENOG502RNSJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1587814_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKB2"/>
    <dbReference type="OrthoDB" id="3650064at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="168" mass="19135" checksum="8E9DDC86E45384D0" modified="2011-10-19" version="1">MATLDYGDSTALHAILEDLPQEMFDDIYRRTFSATTAAEQSLITTAGLAHYNIHLELLRVDRASRAQYARSYFRSRTFVTDHSSWIEWLKSLAAEHRVSLLNIEIRLNESPEYAKLSDAIRKSMHDHYHGYVISTLRAQFGEDLAGRLHVEICHTLAPSFVPSRPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKE7</accession>
    <name>F9XKE7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849536.1">
        <property type="nucleotide sequence ID" value="XM_003849488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKE7"/>
    <dbReference type="GeneID" id="13402331"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110887"/>
    <dbReference type="HOGENOM" id="CLU_984205_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKE7"/>
    <dbReference type="OrthoDB" id="10422531at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395661" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32567" checksum="87B380A2236B695A" modified="2011-10-19" version="1">MQRILSLAFLALCAGNVLAAPYTQEDQDSGTTTSKDCYVDQSGKEFCGQSLKSLKSQYQSQCADKVWTQQYPPSPEHQACIDLDKKIREKEALEHDRSQYQTQCADKVWTQQYPPSPEHQACIDLDKNIREKEALEHDRSQYQTQCADKVWTQQYPPSPEHQACIDLSKDIREKEALEHDKSQYQTQCADKVWTQQYPPSPEHQACIDLSKDIREKEALQHDRSQYQDQCADRVWPDIFPPVPAEQACIDLAKKIDEREGLERMKNQYQEQCADAYWGEGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKI4</accession>
    <name>F9XKI4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MGSUL8</name>
        <name evidence="21" type="ORF">MYCGRDRAFT_110909</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849554.1">
        <property type="nucleotide sequence ID" value="XM_003849506.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XKI4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKI4"/>
    <dbReference type="GeneID" id="13402351"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110909"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.626"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKI4"/>
    <dbReference type="OMA" id="YGSYTQV"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000097">
        <property type="term" value="P:sulfur amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Flavdoxin-like"/>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="779"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="215"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1540" mass="169985" checksum="736C2196644CB11B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKW1</accession>
    <name>F9XKW1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848996.1">
        <property type="nucleotide sequence ID" value="XM_003848948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKW1"/>
    <dbReference type="GeneID" id="13398330"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96427"/>
    <dbReference type="HOGENOM" id="CLU_1994409_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKW1"/>
    <dbReference type="OrthoDB" id="3233795at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395550" description="Cystatin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14272" checksum="3925B3C2EE9DDCEA" modified="2011-10-19" version="1">MRFPLLLTTLLSALTSARILTSTDPLGQPAAHVHKAANFVRAEYHMLEFHDQPVKENTYYIAYVVRFETAARGMIVFQWKTYDEKFVVDDDIPARLVFQSNNVLYASSSPAPCRSRADMGEGRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKY3</accession>
    <name>F9XKY3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_76012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849229.1">
        <property type="nucleotide sequence ID" value="XM_003849181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKY3"/>
    <dbReference type="STRING" id="336722.F9XKY3"/>
    <dbReference type="GeneID" id="13396593"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76012"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="InParanoid" id="F9XKY3"/>
    <dbReference type="OMA" id="YYVFHGP"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="433"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="903"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118260" checksum="0CA388762ECC7240" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL05</accession>
    <name>F9XL05_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_17853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849219.1">
        <property type="nucleotide sequence ID" value="XM_003849171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL05"/>
    <dbReference type="FunCoup" id="F9XL05">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="13398766"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17853"/>
    <dbReference type="eggNOG" id="ENOG502S6ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060368_1_1_1"/>
    <dbReference type="InParanoid" id="F9XL05"/>
    <dbReference type="OMA" id="QGTLFEY"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18907" checksum="B1BE0CCF2E626B91" modified="2011-10-19" version="1" fragment="single">APTTNHHDLASFLEHSRNIDSKTGTTVYRGTHYEYTVIEFLRTYNFTLRRTGRSNDLGIDLLGQWQLPSDPQELRVLVQCKASKPRPAMVRELEGAYVGAPAGWRGADVMALLITRDPATLGVRNALQRSRLPMGFAQITENGAMRQFMWNHAAQEARLTGMSVTNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL44</accession>
    <name>F9XL44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_111048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848876.1">
        <property type="nucleotide sequence ID" value="XM_003848828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL44"/>
    <dbReference type="FunCoup" id="F9XL44">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XL44"/>
    <dbReference type="GeneID" id="13398595"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111048"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.286"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084507_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL44"/>
    <dbReference type="OMA" id="LKWSVEN"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="5">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="215" mass="23452" checksum="5DE03925DEB0D1B4" modified="2011-10-19" version="1">MADQQSLNQLLQWGIENSSASQSDPSTASHPKSDLNPKLLSELLGGPSDADLMRMAMTSILDAETPLDQKLIAWENLELLIEQIDNANNMEPLGLWPPLIKQLDNDEAEMRRSAAGCVAAAVQNNVKSQEIALGHDGLVDGLVKLATEDSTQAVRKKAISALSGLVRNFQRGLDEVETKLPQDVWQRSKTGLDASDMEQVDTLIGRLRERSAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLE3</accession>
    <name>F9XLE3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_19110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848901.1">
        <property type="nucleotide sequence ID" value="XM_003848853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLE3"/>
    <dbReference type="STRING" id="336722.F9XLE3"/>
    <dbReference type="GeneID" id="13398146"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19110"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_3_1"/>
    <dbReference type="InParanoid" id="F9XLE3"/>
    <dbReference type="OMA" id="GGRGCYP"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="74" mass="8297" checksum="6A7BA30545F43223" modified="2011-10-19" version="1" fragment="single">FVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLU9</accession>
    <name>F9XLU9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FUS1 actin binding activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FUS1</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_49181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848951.1">
        <property type="nucleotide sequence ID" value="XM_003848903.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XLU9">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLU9"/>
    <dbReference type="GeneID" id="13398196"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49181"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="InParanoid" id="F9XLU9"/>
    <dbReference type="OMA" id="NHYWKAR"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
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    <sequence length="1737" mass="192048" checksum="202C866B66551A60" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EGP83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="107" mass="12123" checksum="ED430C3EBC11868A" modified="2011-10-19" version="1">MALAWTSTADDLIRVEATFDGVVYFDSALWLQTNIEVKQTRYNEITVLPWTCVLLYRARALRTILMFSHSLRGSCFLKRCARTEPTMAAMATIKVVERMVPNAFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
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            <end position="176"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1257" mass="137910" checksum="83CA42BEAF9D0C3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XND5</accession>
    <name>F9XND5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_88089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848418.1">
        <property type="nucleotide sequence ID" value="XM_003848370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XND5"/>
    <dbReference type="FunCoup" id="F9XND5">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XND5"/>
    <dbReference type="GeneID" id="13396247"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88089"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_15_1_1"/>
    <dbReference type="InParanoid" id="F9XND5"/>
    <dbReference type="OMA" id="AWGSIYR"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="492"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="743" mass="81770" checksum="C4D490E10476383F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNP4</accession>
    <name>F9XNP4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_50884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847932.1">
        <property type="nucleotide sequence ID" value="XM_003847884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNP4"/>
    <dbReference type="STRING" id="336722.F9XNP4"/>
    <dbReference type="GeneID" id="13401658"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50884"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.195"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_0_1"/>
    <dbReference type="InParanoid" id="F9XNP4"/>
    <dbReference type="OMA" id="SERMERC"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="303" mass="33356" checksum="86E93D9BB646C3E3" modified="2011-10-19" version="1">MLEYLRLKLLVTSIRLPVAIKAFISGSRPQPDEVIHIPSREPGRVINANVYKATLRNGPQPVLINFHGSGFVLPLHGSDDEFCRHISTNTDYTVIDVAYRLAPEYPFPAALEDVEDAIRWAKSQPKIYDLTRLSTSGFSAGANLALVASASSFTKGTINSVIAYYPPVDIAQDPDSKVAPDPSGNPIPASLARIFNDCYLQSGVDPKDPRVSPTFLSVDSFPSNLFLITCGLDTLAPEAEELAERLKKVEGINLEHKRMEKCDHAWNISTQEGTPQDAAKKEAYAMTVDFLNRLGISWQGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNV0</accession>
    <name>F9XNV0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
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        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
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        <property type="protein sequence ID" value="EGP83073.1"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
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    </dbReference>
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            <end position="69"/>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="75" mass="8651" checksum="9C0185DD11371EB2" modified="2011-10-19" version="1">MFSRAATRAPATLSRRAFSTTRAQFASPYHYPEGPRTNIPFNPLTRFFWLRYWGFMAVGFGAPFGIAVWQTMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP19</accession>
    <name>F9XP19_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_97150</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP19"/>
    <dbReference type="GeneID" id="13402130"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97150"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.330"/>
    <dbReference type="eggNOG" id="ENOG502QPIW">
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    <dbReference type="HOGENOM" id="CLU_014633_1_1_1"/>
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    <dbReference type="OMA" id="KHGRKMN"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="Lys/Orn_oxygenase"/>
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    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lys_Orn_oxgnase"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="552" mass="61249" checksum="C2376AAA8329B81A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP30</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP30"/>
    <dbReference type="GeneID" id="13402061"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97160"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.347"/>
    <dbReference type="HOGENOM" id="CLU_1103512_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP30"/>
    <dbReference type="OrthoDB" id="10498109at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="252" mass="28009" checksum="FE54C0BCC11F0A39" modified="2011-10-19" version="1">MSPIYGWTPGQDSSPITILTIAGVVLLLNFVCFTLGWALGRQSPESVSHEKIVLRSRLELLEVHNGCVGYSPGTIGQGKSKMTGGSEASTVVASRPMRATEKSDAIEIGTIEGSRTTETNYQTIGIEQVETHQAEERSTVSQSKNKKTPEERKARLKLRMLEIQRAMSIFDRRPAIVGEEPDIRLVFKGESQTKKCSTCRKWDVNLQRAMGEEFGKIGREMEVLGHQVGINDKGKLFLKAKRDEGEESKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848011.1">
        <property type="nucleotide sequence ID" value="XM_003847963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP49"/>
    <dbReference type="STRING" id="336722.F9XP49"/>
    <dbReference type="GeneID" id="13396084"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97179"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.366"/>
    <dbReference type="eggNOG" id="ENOG502R9QM">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327373_0_0_1"/>
    <dbReference type="InParanoid" id="F9XP49"/>
    <dbReference type="OMA" id="CCRREET"/>
    <dbReference type="OrthoDB" id="10389680at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="523"/>
        </location>
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            <end position="687"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="879" mass="91333" checksum="34281F899228A118" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPA6</accession>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
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    <dbReference type="STRING" id="336722.F9XPA6"/>
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    <dbReference type="HOGENOM" id="CLU_026126_2_0_1"/>
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    <dbReference type="OrthoDB" id="415696at2759"/>
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    </dbReference>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847763.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="13400820"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106449"/>
    <dbReference type="HOGENOM" id="CLU_2549378_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPP7"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="83" mass="9486" checksum="499D37237F01B083" modified="2011-10-19" version="1" fragment="single">MRSQDATNRRQAARASANNSCYFGNPCDACRWEIEPSHGNVLDRPGPWISVISMVHHHFLVEWFSFDLLSRPRHAAPSPMTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPT3</accession>
    <name>F9XPT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_64546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="171" mass="18957" checksum="F5E189434091359D" modified="2011-10-19" version="1">MAKIESGPAPNALRATRIQAPVNFNLHAYCSASSSSLRSRDAVDMERPLRSIAGDGGNDKVVLRVGQFQQRGVENKLVSSIYPSVHVCRCEPSERTCQSTSATRQKVEKQETGTNNLADEIAALSVRQTREKPGEDKEEEEEEEEEEEEEEDGTVDGMIVKLLPRLGKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRN2</accession>
    <name>F9XRN2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847123.1">
        <property type="nucleotide sequence ID" value="XM_003847075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRN2"/>
    <dbReference type="GeneID" id="13399441"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97877"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_18.39"/>
    <dbReference type="eggNOG" id="ENOG502SSXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687374_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRN2"/>
    <dbReference type="OMA" id="DHEMARI"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="174"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="401" mass="43815" checksum="9397F6773DA42D0D" modified="2011-10-19" version="1">MDANADRNTPKKRRALNKQDDNVLLIPADEDEENVDVDVDVNVTPRPLQQPPPLLHSQLPISRTNLSLVDSAPNFPPRRPDDRSNKRSMADDATSSTSARSSKASRRSASPQKEAAARAFALYPVAQGTLAVLGEDTPQDVLDLVDKMEGRRALQTRKPQHDAHVLRTIFKDVNVAGEPAPDRQHLARLVCKAEQHRVRGASEAAWNSAVHHPLLEASLVDSRFDADFRFENITTATISPLALPPSVFSAGGDARKVDFCLAFDIPPDLKAVLVERQVHLNQTEYTPVEFDAIAFSIETKSSTTASSDEGLRQLSIWAQAQVIRLRQLLDAYGRKDGGVVEIPVLPLLLVQGHEWTLVCFKDGAGRGRAGGTFYSGGITFGSTSGLLEACKIVEGLRLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRV9</accession>
    <name>F9XRV9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_51785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847053.1">
        <property type="nucleotide sequence ID" value="XM_003847005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRV9"/>
    <dbReference type="GeneID" id="13399253"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51785"/>
    <dbReference type="HOGENOM" id="CLU_3130066_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRV9"/>
    <dbReference type="OrthoDB" id="3693885at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="50" mass="5799" checksum="7E359EDB4814D6E7" modified="2011-10-19" version="1" fragment="single">LLMTLVTIKADNMSQIALTKRGGVDGRTKHINNRLHWLREQVNDHKVTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRX0</accession>
    <name>F9XRX0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847017.1">
        <property type="nucleotide sequence ID" value="XM_003846969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRX0"/>
    <dbReference type="GeneID" id="13399412"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97964"/>
    <dbReference type="HOGENOM" id="CLU_2123016_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRX0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="114" mass="12490" checksum="A4A63211E8055A2A" modified="2011-10-19" version="1">MSGLLHTVGRTVEDSATYKTTETWLAVCNVVSVELGSRGFERVVASQPRRVPTNFCHHARRRRSTPSSATNMGWDGKVAYHVASGAYVDHGSHSSSSTRRALDNPELECVEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSD6</accession>
    <name>F9XSD6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846874.1">
        <property type="nucleotide sequence ID" value="XM_003846826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSD6"/>
    <dbReference type="GeneID" id="13396640"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98126"/>
    <dbReference type="HOGENOM" id="CLU_1533785_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSD6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="175" mass="19822" checksum="558AD6ED5E50382B" modified="2011-10-19" version="1">MFSYRRDQAIEASTCMLGLRYQALRDARDFWTTALSSVASGVHLGSADELAFLDAKVIYFIPEALIPDKFYTSAGQFADFSILAFQKYRIKKDVMHCVGGVVQWRRSCARAVAEDRAGTEKSCSEREESCSDEREALCSDEREELCSDEREESCSDGPAVRKKTCGLWKERRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWA9</accession>
    <name>F9WWA9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856083.1">
        <property type="nucleotide sequence ID" value="XM_003856035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWA9"/>
    <dbReference type="GeneID" id="13394336"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98317"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="F9WWA9"/>
    <dbReference type="OMA" id="KFREVEW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26256" checksum="06BC7656E1E22C0C" modified="2011-10-19" version="1">MAKKTITLVTGGNGGIGFEVVSQLMAASNNHVLLGARSIEKGSAAVKDLESRKLAGTVELLKLDVSDEQSIENAAKQVEEKHGRIDGLVNNAAISQVEGLPLSKQMAICYQTNVIGVQLMGENFAPLLKKSSGTPRIVNVSSGVGSITQKMDPKSRSYDLQYPQYRASKAALNMITACQCREYRDDGFKIFAYCPGFTVSNLSSMNVSANGAKPTSEGAAPIVALLRGDRDGDHGKFVHATGEYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWT1</accession>
    <name>F9WWT1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_66739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856502.1">
        <property type="nucleotide sequence ID" value="XM_003856454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWT1"/>
    <dbReference type="STRING" id="336722.F9WWT1"/>
    <dbReference type="GeneID" id="13395211"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66739"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1410.1"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="InParanoid" id="F9WWT1"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25815" checksum="EA2DC446467521D8" modified="2011-10-19" version="1">MSSLKSLQDAFEKIILDPRYHDPLVLVKAIRNGAVYGTKVRFPHALVMIFLFRSGTLREKARLVFNATRQHASNLARFAFLYKGSMLALRKTNGGKEVGAHHFLAGLFGGYWVFGQSANSVNQQIVIYVFARVVLALAKLAVQPPGDNSLVGSHYGGRGGIGIFKLTPEQAATIRKYSWPAFASLSWASVMWLFESYPETLQNSLRSSMYYIYANSEKWDSSRNFLLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWZ8</accession>
    <name>F9WWZ8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857056.1">
        <property type="nucleotide sequence ID" value="XM_003857008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWZ8"/>
    <dbReference type="GeneID" id="13395409"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89949"/>
    <dbReference type="eggNOG" id="ENOG502R9VY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147969_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWZ8"/>
    <dbReference type="OMA" id="RNHNFAH"/>
    <dbReference type="OrthoDB" id="3648311at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27381" checksum="83546F131F7B7F9E" modified="2011-10-19" version="1">MVKRKRPRTDASTKSLAVDAQSGAKTTVTSSSPTDSETTEEGLHDKNLDNTVRPPFRLLDLPAELRDEIYEKVAQQDPYVVLKGSRLQVASKLCAVSRQVQGEYLAILENSANITTTVVRFDFRPIVRFLNRLSESYVKKLSTLRRTPVKRTINIQLELPSATREEIEMALWHALNPTPEKRGVDMTFSYVFAYSTKYANKDSDFTVTEDWIHGIESFYAGRAEEELDKIIAAFDAWANTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX25</accession>
    <name>F9WX25_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856994.1">
        <property type="nucleotide sequence ID" value="XM_003856946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX25"/>
    <dbReference type="STRING" id="336722.F9WX25"/>
    <dbReference type="GeneID" id="13398705"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90065"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1808"/>
    <dbReference type="eggNOG" id="ENOG502TB88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649253_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX25"/>
    <dbReference type="OrthoDB" id="3884299at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="423" mass="47469" checksum="C3B051F3518282A5" modified="2011-10-19" version="1">MARTKKIKAHVASDALIQQSIADQVRANENRPDRSTIENTNHANRPTAFRARHPRRTATSLPAKLLQPSNSAGFSKFLLPATQLYAHLLDHALPIFHCLIHTVPKLLPRKRASDPRMWIYPEPLLTLIKEQKESTWHYMRQIGEAVDWVVSEPNAGKGLNESDEGMATIQRTRPLLRCGLMGHGATITTSVKMVRAVEDAARSGNDAAGEKWHSSQLAILWLHEMSHAVVHAVLPAEPDTPQHVFLGTDAPTSEVGFEVEQRIFGGIMSLQRDVVPWAGGVCLEEWPDSQTLAYHREMGDLIETRGSSRALTKEWNVLWKVESDFWERMFEEEFWLQEGIAGNLAALHAKRDAGVTAVFKDTTLAEEEAIASEMQSMDYAEVREHLWVKQGSAVGEIETFTQSERNMADKSKSAETSKQQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXR9</accession>
    <name>F9WXR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_65568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857548.1">
        <property type="nucleotide sequence ID" value="XM_003857500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXR9"/>
    <dbReference type="FunCoup" id="F9WXR9">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXR9"/>
    <dbReference type="MEROPS" id="M20.017"/>
    <dbReference type="GeneID" id="13394354"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65568"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXR9"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="214"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP92524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="481" mass="53201" checksum="FAAD7F6E4BF351FD" modified="2011-10-19" version="1">MAPQLDNFYKTVDSLSEPFIERLRKAVEIPSISAEDDRREDVVKMGMFLKSQLESLGAHVEARELGKQPGKEYLELPPAIIGRYPAKKDESKRTILVYGHYDVQPANLSDGWATEPFKLTVDDKGRMYGRGSTDDKGPVLGWLNVMEAHQKAGIEFPVNLLMCFEGMEEYGSEGLDDFIIAECKPGKFFEDADAVCISDNYWLGTEKPCLTYGLRGCSYYSIEISGPGQDLHSGVFGGTAQEPMTDLVRVMGSLVDTNGTIQIEGIKDLVAPLTKEEESLYKGIAFTMDNLYESLGSQTGIYPDKERTLMGRWRYPSLSLHGVEGAFSAPGAKTVIPAKVIGKFSIRTVPNMEPDDVDKLVYAHCDKAFKALGSKNTMKTTLQHAGKWWVASPKHWNFTAAAKAVESVWKVQPDLTREGGSIPVTLTFEQATGKNVLLLPMGSSTDAAHSINEKLDRRNYIEGIKLLGAYLHYVAEEPMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY00</accession>
    <name>F9WY00_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_102384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856250.1">
        <property type="nucleotide sequence ID" value="XM_003856202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY00"/>
    <dbReference type="FunCoup" id="F9WY00">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WY00"/>
    <dbReference type="GeneID" id="13402971"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102384"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.898"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="InParanoid" id="F9WY00"/>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28196" checksum="953A379857FE5B56" modified="2011-10-19" version="1">MAEVAKNPSEPVDLSTIPISPDGAMTDATNGATNGEKSANSGDVVTVFDDPSNFNVKHQLQHTWTLWFTKPPSGKQDWNELLKEVISFNSVEEFWGIYNNITPASELAQKSDYHLFKQGVRPEWEDQQNKHGGRWAYTYKGTKASDETWLNIMLAAIGEMLEDESDNEVMGVVVNIRKAFWRVGLWTRTAGQAPKGRKDEAADPLESRKRLERIGKNFKDVLDLQPNEVIEFSGHADSAHTGSSRAKAKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY72</accession>
    <name>F9WY72_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_33493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856402.1">
        <property type="nucleotide sequence ID" value="XM_003856354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY72"/>
    <dbReference type="STRING" id="336722.F9WY72"/>
    <dbReference type="GeneID" id="13402835"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33493"/>
    <dbReference type="eggNOG" id="ENOG502RZYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_2_2_1"/>
    <dbReference type="InParanoid" id="F9WY72"/>
    <dbReference type="OMA" id="WTWFNLE"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395422" description="Endoglucanase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24653" checksum="2F988D2BDF78F5D0" modified="2011-10-19" version="1" fragment="single">MFSSTSLSAACLLLASVQPALAHMEMRWPLPLHSKFNPDTPENKIDYSMTSPLKNDGSDFPCKGYQNDRPFIPTASYTAGQAYNMTLAGSATHEGGSCQLSLSYDNGATFKVIKSMIGGCPLVNTYDFTIPSFAPAGDALFAWTWQNRVGNREMYMNCAQVSIAASNTRQRRQEAFSTFESLPYLWKANLPGINGCETTERVDPVYPNPGSDVVFGAGLSDISIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYE2</accession>
    <name>F9WYE2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_107601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857046.1">
        <property type="nucleotide sequence ID" value="XM_003856998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYE2"/>
    <dbReference type="STRING" id="336722.F9WYE2"/>
    <dbReference type="GeneID" id="13395417"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107601"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1674"/>
    <dbReference type="eggNOG" id="ENOG502S1DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="InParanoid" id="F9WYE2"/>
    <dbReference type="OMA" id="AAIWIHK"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395425" description="FAD/NAD(P)-binding domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="36"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="44849" checksum="AAAB3067CEDCFFE3" modified="2011-10-19" version="1">MKVNIAFVVQTLACLCTALAQNEVNSERGATAEADYDVVVVGGGYAGLAAASSLGRVRRTVLLVDSAEYRNNYTRRVHDVLGFDGVTPAWIRFRARQQIMEYPTIHFTNGTVDAIQSQGSSSATFFSVSARIGNDEKSTTVTARKVVIATGLRDIIPNTPGLPDCWGQGVWWCPFCDGYEHVDQPIGVLGGLDVSANTPLEILSQNKDIILFVNGTDTPENRAIADKKLPHWDKWLQINNIKVDNRSITSFERLKDGGAVKGDPSRATSPEYDLFRLHFSTGEPVERAGFMTNFKNEQRSMVGANAGVTLYGGRLQANDSKGMETNVPGIYAVGDANTDNSTNVYHAMWSGKRAAVSLHVRIETENAEAEVSNGHGKRDNYVVEDERSLWRRVNGPDDVLKVGEYDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ69</accession>
    <name>F9WZ69_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857385.1">
        <property type="nucleotide sequence ID" value="XM_003857337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ69"/>
    <dbReference type="STRING" id="336722.F9WZ69"/>
    <dbReference type="GeneID" id="13394757"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107195"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.943"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="InParanoid" id="F9WZ69"/>
    <dbReference type="OMA" id="EVYTRQV"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="128"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="653" mass="73778" checksum="D5D321B0A6F5C4C2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZC8</accession>
    <name>F9WZC8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_102585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 115943 / IPO323</strain>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
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                <person name="Hane J.K."/>
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                <person name="Conde-Ferraez L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91280.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="909" mass="97489" checksum="373B3CEF22F7E69D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0V2</accession>
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        <recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Schmutz J."/>
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                <person name="Shapiro H."/>
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</entry>
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                <person name="Conde-Ferraez L."/>
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    </evidence>
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</entry>
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        <source>
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        </source>
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            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1E0"/>
    <dbReference type="GeneID" id="13395380"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24656"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="InParanoid" id="F9X1E0"/>
    <dbReference type="OMA" id="YEEYVFH"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
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    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="117"/>
            <end position="354"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="387" mass="45248" checksum="7A1DDBF0D81947D2" modified="2011-10-19" version="1" fragment="single">NKPSSSDTTKTGWTFVPDRDRNDHSLTSEQCSAAFPDLYREIDRSRAYWKARQGEEKLTDKQWGLEWSSDGGLRVMIWEQQLYIIESRGLNHFLHWKERSHATLHNLQRAILASKEPVPNIEFSIKINDNIALTDKHPNATVWNFNRDVNDKAMEQVWLIPDFNFWAYPRVAGSYGHYQRQAMDMGSDYNSKKPQLVWRGTTDFNPEIRLKLLEAAKDKPWSAVHKVAEDVKDEENMKYRITMPDHCKYKFAVHTEGTTWSGRLKYLLSCHSTIVVHPLTFTTHLYHLLESDGPNQNFVQVRKDWSDLPKTMEALLADNTKAKRIADNAAAKFRDQYFTPAAQTCYFRQLFKVWSEMTPVPDPYEHETLEDGSVQKTWRGMSYEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="F9X1P2"/>
    <dbReference type="STRING" id="336722.F9X1P2"/>
    <dbReference type="GeneID" id="13398411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33442"/>
    <dbReference type="eggNOG" id="ENOG502T2BZ">
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    </dbReference>
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            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP91808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="98" mass="11305" checksum="DF73B6902B60616B" modified="2011-10-19" version="1" fragment="single">SQKPDLATAALLLVILFVSLKILNMLLQSVLFWMRMARKVVFWVGLMAVSVWLYNRGPEGAVEDVQYLAKTWTGEYQHWKEQERVARLVNQGQGKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Q5</accession>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="5">Belongs to the SAT4 family.</text>
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    <dbReference type="eggNOG" id="ENOG502SMYP">
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
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    <dbReference type="PANTHER" id="PTHR33048:SF165">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="33"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="391" mass="43084" checksum="476DC0E7048DD397" modified="2011-10-19" version="1">MVGPSENAGPLLMGLSWTEATIATIVVGLRAYCALRVVRKAEWDLIWALPAWLCNFTSQTILTISVAAYGYGKHLADISESNHIDASRLVWLGQISSAIGAVLARTAIVALMLRVQGEILPRTKWLLHAVCFVNIALGAIQTAMIVKICPVDTPLVGGCDYGLIPSAVIIGYTQAGWAIGSDLFLATYAVVVFRKMRISARRKLAMSFMMGGGYLAAIAATMRMIYLRRLQDSDDPVFNGYPLILWTYTEEWLILILGSLPRLYSFYLILRLKVRTRQGSSGSNLMRSPPNRADLEKQDKQEKTETSEYKVSWPDPVTVNDVGVLPPCVSTVKSVQSCPQQIVVGPAVNRTPFAGVGILPSVYDSDDNEQVMSEEYTENERQQTARSFEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9X225</accession>
    <name>F9X225_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854806.1">
        <property type="nucleotide sequence ID" value="XM_003854758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X225"/>
    <dbReference type="GeneID" id="13395991"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103089"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.245"/>
    <dbReference type="HOGENOM" id="CLU_2833124_0_0_1"/>
    <dbReference type="InParanoid" id="F9X225"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="66" mass="7270" checksum="DFC04AB7A955267A" modified="2011-10-19" version="1">MANPVDDREREPGTAHAARLQELGHVPNSSSDGFLETIASVSMFIQDTAVECLVLCDFWLPQTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X332</accession>
    <name>F9X332_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_108172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855440.1">
        <property type="nucleotide sequence ID" value="XM_003855392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X332"/>
    <dbReference type="FunCoup" id="F9X332">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X332"/>
    <dbReference type="GeneID" id="13399838"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108172"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.807"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038284_0_0_1"/>
    <dbReference type="InParanoid" id="F9X332"/>
    <dbReference type="OMA" id="CELITLQ"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34884" checksum="D80C7722D80DD787" modified="2011-10-19" version="1">MIFHTPPTPAPPPPRVMAVLASSNLSDEINRATRSQHIELNRLLINRLSLALPPHSSTPLLYGKGLVPFARIFLFFEIEWEILIRQVQQSDGYGNEHAREVQRWLANLRPAGLARTARLKDDLRDLRTLGGGGIFDTIDLGEDWMKSMRMTMRRQPHVLVAFAWVFYMATFSGGRWIRQQLANSGDEFWKPDTPHENDTKTPNLELPGFTFLSFDGTQDGEDIKADFKFRLGSAESLLTLEEKDDIILVSQQLFERCTLLVSELDQKVWREKLRSWSWPIVSWMSMAVLTLALLRYVWRFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X388</accession>
    <name>F9X388_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855149.1">
        <property type="nucleotide sequence ID" value="XM_003855101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X388"/>
    <dbReference type="GeneID" id="13400720"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91131"/>
    <dbReference type="eggNOG" id="ENOG502SZT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1338477_0_0_1"/>
    <dbReference type="InParanoid" id="F9X388"/>
    <dbReference type="OMA" id="ANIMPPE"/>
    <dbReference type="OrthoDB" id="5375264at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22347" checksum="00ADF1FD6B0FB46F" modified="2011-10-19" version="1">MSSFDLFDPDTTMRFAAPPSEIGPTPTPANVNASFLHALPTSGPASLTPLQTQQYAARGGMDIATNPRKRPATLPPSDSESETSLPPTASTAPQKRRRPTLAATIDPIISPKEPTPRPIKVRQRKTKGPHASSRVIPRSLADCDAADQMLIEMREAGSDWNPIRAKWLELTGEKTATSTLPNRYSRLKYITQNPSRHPPHLPSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3B5</accession>
    <name>F9X3B5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_37187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854692.1">
        <property type="nucleotide sequence ID" value="XM_003854644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3B5"/>
    <dbReference type="STRING" id="336722.F9X3B5"/>
    <dbReference type="GeneID" id="13403765"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37187"/>
    <dbReference type="eggNOG" id="ENOG502QQ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037759_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3B5"/>
    <dbReference type="OMA" id="FNVRILS"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49612" checksum="9C3AF04B3460EB67" modified="2011-10-19" version="1">MNDSTMDRLPTTLVDLLSNSLVLRGTAPYITIRDLLNLSSTCRALRQILRGEPDAWRHLNLTTIKRAVIDSSPIDVGGVSWRAERMDESLTEDDFYAGPLRGIFNRLHSQRNLKHVQTLILDGLSVPADLIREIVAEDRYQVRILSIRGVKNLNPNRLQQVLRYVCRPTREEGTPRLKALYYFGPKDAPLQPIPSLPPTAPPSLGVMSSPGAQIGASWNARSSELLKTTLISSEESQYYSCTGRVLKKPYSDWAETLQVCHNIIHFDAVLCRGPRHDISKTSSKDFLQPTIATVALGPGGCETCHSCPELPASFPDSPPPHLPLLGPVPTHSSTVRSCIRPDDPSSNRLILRCEDCLRGRWCEQCNRWWCEDCYEEPVSRSAHHLRTEMQTIELRDQIRSGGWSAMDSHVLPVKGQQTKVFSKLCVEHCLVGEMMAGAGSGGMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3I3</accession>
    <name>F9X3I3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_103147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854859.1">
        <property type="nucleotide sequence ID" value="XM_003854811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3I3"/>
    <dbReference type="GeneID" id="13399348"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103147"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011919_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3I3"/>
    <dbReference type="OMA" id="WIAYAFV"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="288" mass="32474" checksum="AFCB53E6273117AB" modified="2011-10-19" version="1">MERDMVFLPRTRDEHATRTGALLHEMHELMEETPIYTAVSMIVQQLGGWPMYLIQNLTGHNNHEKQPEGKGVGKKNGNGSVNHFLPSSPLYEKKDEHLILLSDLGLAITASVLTYVGKTYGFTNLLVWYILPYLWVNHWLVAITYLQHTDPSLPHYTGDAWNFARGAAATIDREFGFIGRNLLHGIVETHVLHHYVSTIPFYHADEATEAIKPIMGQHYRADVEGGSIGFLKAMWKSARWCQWVEPLPGTTGEESKVLFFRNRNGLGVPPAKLSPKAGKRAMVEDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X459</accession>
    <name>F9X459_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_79251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855738.1">
        <property type="nucleotide sequence ID" value="XM_003855690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X459"/>
    <dbReference type="GeneID" id="13403678"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79251"/>
    <dbReference type="HOGENOM" id="CLU_3089074_0_0_1"/>
    <dbReference type="InParanoid" id="F9X459"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="52" mass="6195" checksum="6FBE324254788FA4" modified="2011-10-19" version="1">MERKQSSRVVREFATTFPSEFTQRLRPRPPLHSGKMPVPTRVSFHHRCDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4C4</accession>
    <name>F9X4C4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855616.1">
        <property type="nucleotide sequence ID" value="XM_003855568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4C4"/>
    <dbReference type="GeneID" id="13399385"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90661"/>
    <dbReference type="eggNOG" id="ENOG502RG5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823830_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4C4"/>
    <dbReference type="OMA" id="CTSGEHY"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="322" mass="35649" checksum="1AD18EC39DBD1127" modified="2011-10-19" version="1">MAGERQPSQNAHLPTDMDHMHFHAIQRSNGRTESTSTENVPSRIQQDLENRPHLAPRNVDITKKVSPYGHDDAADVQTMASLSKRQILNDASFNASLTSQGDSEQGSLPPVERHLQVAIPTSSPGLTTFAYQRALRNRIEASKLLKDNTYDLTRYTPTFIHDALMLPGSLAGLLSKGSAGDLINRMTPAFLPGCHAHLDQESLQPCLVRADNAQSYVQGMLVFGQGKASRDAVHQHYRPGAKRRKVGVEIDVEWTIEDSLAGTLEEEMPMRIELDGKGDEAHEEWLTEDSSVATLAGKEEGQVNGKHEAPAFYSFERDTWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X504</accession>
    <name>F9X504_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855228.1">
        <property type="nucleotide sequence ID" value="XM_003855180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X504"/>
    <dbReference type="GeneID" id="13400473"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91286"/>
    <dbReference type="HOGENOM" id="CLU_691177_0_0_1"/>
    <dbReference type="InParanoid" id="F9X504"/>
    <dbReference type="OMA" id="FAPTHFL"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="399" mass="44758" checksum="C5A3860D5478A6EE" modified="2011-10-19" version="1">MSATTERITIGVVGRSGSGKSATLNSEFQVGEIARYGGSVSCVTFTTNLYCGKRTDQISPLLAEVFFFTEADRYKMISRWIHDYDSAAAPDPTQRMMATAAQLMVCQALETIFKDHPECEDYRAVYRFLDDAKPGNNGAIGAKLVQWSNDLLARTIGAKKTITVTGVHATDLLTQLRPYDSKMREGPSLWPFVSLIRFHVDNPLTAKGIHFLDTPGHIVSDFTRQYNAARYRLRMRHLGKDRVVVVVTKTDIIGDHSMSGSLRDEALARKFKDRLTQLEAEDKSVDIDMEDALEAGIQSGDLSNYFAPRTRHTELKTMVRCATAQEKVHRIKMRGEIIFNALQPDLFGYTESPVPVCSVSDSEYAKHVDGYEATYDKEPFMSLEETDIPNLRRLIGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X572</accession>
    <name>F9X572_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_24531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854282.1">
        <property type="nucleotide sequence ID" value="XM_003854234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X572"/>
    <dbReference type="GeneID" id="13404339"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24531"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_0_0_1"/>
    <dbReference type="InParanoid" id="F9X572"/>
    <dbReference type="OMA" id="VAHTEGH"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="102"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="376" mass="43841" checksum="7C13932EBAF59E3C" modified="2011-10-19" version="1" fragment="single">WSFDFKRDARNFGLDEEQCLAAFPDFYKEIDRAIQYRKKVAGKIKPEELEVDWRFDGMMRAMIHDNQLYIIDAHGLAPPNHRARAIATLNAIQRALTSSAIPLPDIEFTFSVHDDAHTSEDDTHTTWAYSRKAHQTSLWLMPDFGLWAWPDVNIRSYSELRTQLALSESHFLDKIPKLVWRGSLAVGSHDVRAGLVEHAANQPWSDVMELDWSDKSNINSRLLSMSDHCEYMFVAQTEGNTYSGRLKFLLNCHSILFSHRLDWIENYHHLMQPTGEFQNFVQVKRDYSDLPKKITRLLDPKEVQRTELIADNARKIFRERYLTPAAEACYWRALIRGWASVQDFEPNFWWEVTETTAEGKTLKRKPRGTPFEAYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X585</accession>
    <name>F9X585_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_70268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854277.1">
        <property type="nucleotide sequence ID" value="XM_003854229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X585"/>
    <dbReference type="STRING" id="336722.F9X585"/>
    <dbReference type="GeneID" id="13404346"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70268"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.859"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="InParanoid" id="F9X585"/>
    <dbReference type="OMA" id="MDHAQSE"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="294" mass="32230" checksum="8FFFD7CA85BE8CE3" modified="2011-10-19" version="1">MSLQKLSDNRAVQMLSAAAAGKYGVLGIVAYNLETIVAIIRAAEAKRSPVQILLFPWALQYSPLFIDLAANAARKASVPVTVHMDHAQDPEIIKAAAKIQAADGTPAFDSIMVDMSHYEKEENLAKTKELVALCHERGIATEAEPGRIEGGEDGVQDTAELEGMMTTEEEIDEFVATGIDFLAPAFGNMHGDYHGVHNIHLDYERLEMIQKKAAGRVTVVLHGTNEFPKDIMAKCIERGVTRVNVNKLVLSDYNAYVDEYTGKVPLTQLMERGTELIQKQTEEWMDAIGSTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5U2</accession>
    <name>F9X5U2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854251.1">
        <property type="nucleotide sequence ID" value="XM_003854203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5U2"/>
    <dbReference type="GeneID" id="13395437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103900"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.904"/>
    <dbReference type="HOGENOM" id="CLU_1950517_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5U2"/>
    <dbReference type="OrthoDB" id="10343356at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391149" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="129" mass="13721" checksum="8405F81B9B89220A" modified="2011-10-19" version="1">MKSVIFAIATLATLAAATADSLVVRHVVSDEFAHMKFRSVHRRMPQELDQNSCETNWDCGTGQQVIYKDGQCTCKITNGGAACAAAGGDGNTWYTDAEGHTCCPFGGSPPPELQNAKPLCPQKHNGTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6R9</accession>
    <name>F9X6R9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_69654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853765.1">
        <property type="nucleotide sequence ID" value="XM_003853717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6R9"/>
    <dbReference type="FunCoup" id="F9X6R9">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6R9"/>
    <dbReference type="GeneID" id="13404104"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69654"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.371"/>
    <dbReference type="eggNOG" id="KOG2018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="InParanoid" id="F9X6R9"/>
    <dbReference type="OMA" id="GSWVVTM"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="105"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="504" mass="55614" checksum="FA8D6A51610B358F" modified="2011-10-19" version="1">MSSWLSNVASSHKVQLGVTAVVSGCIAAVAVIGLQKARKEYNVHDLKGSIPDLDEPHDVEKINNFGGAVPEELLENRDDERSAALARRARLGDYDEALILEQLARNRVFLQDDGLAKLRKAFVIVVGCGGVGSHATAALARSGCGRLRLIDFDQVTLSSLNRHAVATLADVGTPKVKCLEKRMEQIVPWTHFDSRNELFGEATAAKQLEPWSDGQKPTYVIDAIDNIDSKVALLYYCATNGIPVISSMGAGCKSDPTRVFIGDISASTDDPLSRSTRRKLRMRGVKDGIPVVYSQEKTGPGKAQLLPLPEDEFQKGAVNELGVLPDFRVRILPVLGTMPAVFGLCVANHIMLEIASYPHDYLASKAREKMYDGIMGHLSGLEERLAKHQGYESTGLRLPVTNDDVGYLVEEVFRGRSVVSGLASRLVLTRWRKPEGPWVDLSTPGQKADTLRLDELVCMTKDEMLKHEKIVLKEGRTPEEVYGKEVVELVEKRMKEERAYRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6W6</accession>
    <name>F9X6W6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853913.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6W6"/>
    <dbReference type="GeneID" id="13404252"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103794"/>
    <dbReference type="HOGENOM" id="CLU_2591617_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6W6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="8788" checksum="FF0217AFAEE7979F" modified="2011-10-19" version="1">MLLASGYDSPHPRWHRARACADDLLVCSSSQCAHQQVVPVVPAPKCLPDVVDLMTGCELRCKCSQQAHRPPAVWVHGPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X737</accession>
    <name>F9X737_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854197.1">
        <property type="nucleotide sequence ID" value="XM_003854149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X737"/>
    <dbReference type="GeneID" id="13404537"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92127"/>
    <dbReference type="HOGENOM" id="CLU_315027_0_0_1"/>
    <dbReference type="InParanoid" id="F9X737"/>
    <dbReference type="OrthoDB" id="3650975at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="928" mass="106645" checksum="A3276DCD38FDB13C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X878</accession>
    <name>F9X878_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Threonine dehydratase</fullName>
            <ecNumber evidence="14">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_70685</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="14"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853570.1">
        <property type="nucleotide sequence ID" value="XM_003853522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X878"/>
    <dbReference type="FunCoup" id="F9X878">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X878"/>
    <dbReference type="GeneID" id="13400691"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70685"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.99"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="InParanoid" id="F9X878"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
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        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
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        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Thr_deHydtase_biosynth"/>
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    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
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        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
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        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="16">
        <location>
            <begin position="398"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="16">
        <location>
            <begin position="494"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="10"/>
            <end position="20"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001274"/>
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            <dbReference type="ARBA" id="ARBA00001933"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="575" mass="62323" checksum="ED04014144183036" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8H2</accession>
    <name>F9X8H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_109145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852973.1"/>
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    </dbReference>
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    <dbReference type="OMA" id="PVPKWAQ"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="261"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="695"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="767"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1027"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1237" mass="137374" checksum="EAC853677AAC3777" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8X1</accession>
    <name>F9X8X1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_70943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853480.1">
        <property type="nucleotide sequence ID" value="XM_003853432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8X1"/>
    <dbReference type="FunCoup" id="F9X8X1">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8X1"/>
    <dbReference type="GeneID" id="13397257"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70943"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.303"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="InParanoid" id="F9X8X1"/>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="310" mass="34179" checksum="FA7E2F38FA1D44B7" modified="2011-10-19" version="1">MATSTSGTFTTPDGHSLYTLTYTPPSSTPPIARLIHLHGFSDHAHQHAQFFQYLASTHAIKVYAFDQRGWGRSVHTPKEKGLSGPTSQVMEDITSFVESLPAEESDIPLFLMGHSMGGGECLYYAAMGPAETKRKIRGFIASAPWIAVHEDTRPSFITVAVGRLVGKLFPHRQMVNKVDASKLSRDEEVCKIWHEDEHCHDTGTLEGLAGALDRGGDLETGKVVVKDGVGEGGKTRLFIGFGTADKVVSYTVGRKWFEACKVEDKEFRAYEGWYHNLDMEPGEDKITFANDVAKWVKERSGSLESGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X938</accession>
    <name>F9X938_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853365.1">
        <property type="nucleotide sequence ID" value="XM_003853317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X938"/>
    <dbReference type="GeneID" id="13399263"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92656"/>
    <dbReference type="eggNOG" id="ENOG502SVSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953798_0_0_1"/>
    <dbReference type="InParanoid" id="F9X938"/>
    <dbReference type="OrthoDB" id="3920481at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="292" mass="31801" checksum="9014577B022B501A" modified="2011-10-19" version="1">MKRLSEVRAGDDKTGLGSDQEHPTRRSAPDNLPIVKIPKAGARPNLLKRAIPGVKVWDILSELVDAQRIKGRSASTTQTVRYSSCLITRMPERQSDGAAKCACDQSLVWSRWAAGIRLPGNLQRGPILLADVDCLPDYFSITPRANNTADVLSVDINTEHLPADSPYYSPAPSVQVHSLLAPRPSITPTSTMASTGSFMQMQTSASHTPSRPQHIQNVLHVTSDDSTSSDSSSSSSANSALYSSPEFARCSRCHRASSIDWKTGQDKNMMRYGLNLWYCNRCASIVGMIPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9E5</accession>
    <name>F9X9E5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_70812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852886.1">
        <property type="nucleotide sequence ID" value="XM_003852838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9E5"/>
    <dbReference type="GeneID" id="13397207"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70812"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.194"/>
    <dbReference type="eggNOG" id="ENOG502QPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="InParanoid" id="F9X9E5"/>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="505" mass="55301" checksum="53609AB20CF7BEFC" modified="2011-10-19" version="1">MSTFVLTRHAFTSAIRQSHLPPAASISLRTTWQRRTFSRTSWLAIAVAEMAEKDFSSLRVNQERLMNDIHSTSEWGKGERWGSGDTEIGMSRLSLSDTDKQARDWFAETTQALGCKVHTDAMGNQFAVRPGLKEGPPTYAGSHLDTQPSGGRYDGILGVCAGVELLKVLNDNWVETNYPVGIVNWTNEEGARFPMSMMSSGVWAESIPLEKAHNLKSVIPANDTATVKSELERIGYLGSTPASYKSTPMAAHFELHIEQGPILEAEDRRIGVVKGVQAYKWFTLTVHGRDAHTGATSFQHRADSLLTASKLILASHRIAHRYKALASTGILTLKPGSTNTVPGFVQFSLDIRAPRNETVEQVEQECRVAFDQIAAGADAEGVNTGCAISERECTVEWQTDFENPATYFHDDCIACVRKAGADLCGDDKVKGLNLGKWGKFMTSGAGHDSVYTNKHCPTCMIFVPCRDGVSHNPAEYSSPEQCADGANVLLGAVVRYDKLRGEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9G7</accession>
    <name>F9X9G7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_31129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852900.1">
        <property type="nucleotide sequence ID" value="XM_003852852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9G7"/>
    <dbReference type="STRING" id="336722.F9X9G7"/>
    <dbReference type="GeneID" id="13397221"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31129"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082854_10_3_1"/>
    <dbReference type="InParanoid" id="F9X9G7"/>
    <dbReference type="OMA" id="FFMEIRP"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="90" mass="10789" checksum="E4BDBFD2BA536D2D" modified="2011-10-19" version="1" fragment="single">QKRQYKQRDMNAPKRPLTAYFRYLREQRPILTREMAENPDTEGTKAGDISKLATERWKALTDAEREPYKQAYQKELLKYETDTKAYKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9J9</accession>
    <name>F9X9J9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_71048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853443.1">
        <property type="nucleotide sequence ID" value="XM_003853395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9J9"/>
    <dbReference type="FunCoup" id="F9X9J9">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9J9"/>
    <dbReference type="GeneID" id="13397286"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71048"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.368"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9J9"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="315" mass="34422" checksum="A722C451E4A17C84" modified="2011-10-19" version="1">MDRPNKPSALSPSTTGPQPSVHADKGRVVAVLPTGDSVEVLLYGASVISWKTNGKERLWLSTAAKLDGSKPVRGGIPVVFPAFGPPPKDHATSALPQHGFARNSTWEYLGKSSSESGSLAKGGDDSVKLDFGLSHNNLSEEHKKAWPYEFALVYSVTLSKDGRLQTMLNVSNSGKESFEFQFLLHSYFLINDITRTQITGLGSETYIDKMLNATEHKQSPANISIAGEVDRVYKGIKQDTTSVVEDGKPHLDVIRDNLADTVVWNPWIEKSKGMSDFEPKDGYKTMVCVEVGTVDGWQKLESGDTFEAGQILKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9L0</accession>
    <name>F9X9L0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_71062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Foster A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852376.1">
        <property type="nucleotide sequence ID" value="XM_003852328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB38"/>
    <dbReference type="FunCoup" id="F9XB38">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB38"/>
    <dbReference type="GeneID" id="13394153"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72625"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="InParanoid" id="F9XB38"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="497" mass="58316" checksum="75E6F31D63AE865E" modified="2011-10-19" version="1">MDSPAVNRLFRRLAGHHFCHHAHQAHRPLSTTQICRDNKYTRSGSRRDVKTTSESSWQQRTDHFPEDKRAEFQRYPSVTADALRARRERPRRVKMLMRDFIEDSLYNPHYGYFSKNVTIFSPGAPFDFNSLKDEPEFYQKLGERYTEFEDKLDEENPSETRQLWHTPTELFRPYYGEAIARYMVANYKLTLYPYHDLVIYEMGAGNGTLMLNILDYIRHADPEVYARTKFRIIEVSSALASIQADKLLTTASTRGHADKVQIINKSVFDWDLYVPTPCFFLAMEVFDNFAHDVVRYDPSTEEVLQGSVLIDSDGDFYEFYSRTLDPVAARFLRVRDAACQDRSYPHPLRQPRFIRQLRHQLPFAPNLTQPEYIPTRLMQFFSILSTKFPAHRLITSDFHSLPQTIKGYNAPVVQTRYQRRTVPVSTPLVQQGYFDILFPTDFGVMEDIYRAITGRLTRVMTHEDFFQRWAYVEDTRMRSGENALLGWYKNASVMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB92</accession>
    <name>F9XB92_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_41422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852102.1">
        <property type="nucleotide sequence ID" value="XM_003852054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB92"/>
    <dbReference type="STRING" id="336722.F9XB92"/>
    <dbReference type="GeneID" id="13393877"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41422"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.186"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_1"/>
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    <dbReference type="OrthoDB" id="566138at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391261" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="540" mass="57994" checksum="A44C5676D1A6F281" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBQ6</accession>
    <name>F9XBQ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852152.1">
        <property type="nucleotide sequence ID" value="XM_003852104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBQ6"/>
    <dbReference type="GeneID" id="13396995"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93152"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.286"/>
    <dbReference type="HOGENOM" id="CLU_302109_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBQ6"/>
    <dbReference type="OMA" id="KAHETRR"/>
    <dbReference type="OrthoDB" id="10374300at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="988" mass="107262" checksum="2AC31EE3FB23BCB3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBR2</accession>
    <name>F9XBR2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_59299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852289.1">
        <property type="nucleotide sequence ID" value="XM_003852241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBR2"/>
    <dbReference type="FunCoup" id="F9XBR2">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBR2"/>
    <dbReference type="GeneID" id="13396843"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_59299"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_6_0_1"/>
    <dbReference type="InParanoid" id="F9XBR2"/>
    <dbReference type="OMA" id="NSKREFG"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="3">
        <location>
            <begin position="219"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="37818" checksum="5661D32FDE05A79E" modified="2011-10-19" version="1" fragment="single">MGIQELPQNTVRALGANQALTDPASLVKELIDNALDANANSISVEISNNTLDTIQVRDNGHGIAPEDRELVARRYCTSKISRHQDLKDIGGSSLGFRGEALASAAELSGGLVVITRVEGEQVSTALKINQQGEVVGQERASSSIGTTVKITDFIKANPVRKQVALKNTDACLKKIKRMLQAYAFARPHVRISLKVLKAKNNKGDFVYAPKPNGNAEDAAFKIVGAACSSQCIWSVLEERGFTLQAFLPRPDADLNKVCNTGTFLSVDARPVSTTRGHLKQMMKIYRESLKALHPKHGEIKEPFLFLEISCPQGAYDANIEPAKDDVLFEDADIVVEMVKQLFRTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBR6</accession>
    <name>F9XBR6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta carboxy-cis-cis-muconate lactonizing enzyme, cyloisomerase, CLME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CMLE1</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_86202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852517.1">
        <property type="nucleotide sequence ID" value="XM_003852469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBR6"/>
    <dbReference type="STRING" id="336722.F9XBR6"/>
    <dbReference type="GeneID" id="13396840"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86202"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.600"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_3_1_1"/>
    <dbReference type="InParanoid" id="F9XBR6"/>
    <dbReference type="OMA" id="KFVHWGA"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="372"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="464" mass="50399" checksum="863166D85D3BA6E0" modified="2011-10-19" version="1">MPISALDSLLFKNLFGTSSIRSIFDDKSYINYCVQVEAALARAQAQHHVIPASAAEHITQTCQTIELDYDRLSTETEVVGYPILPLVRQLAAQCGEGGDEAGRYVHWGATTQDIQDTASVLQMKAGLDLVETHLTALCKSLSKLAGKYRDTPMAGRTHLQHALPVTWGYKCAVYLSSFQRHFERLRELRPRCLMVQFGGAAGTLASLGEGAEGKGMAVRKSLAEELGLGDPDITWHTARDGVAEILNFLALVGGSLGKVAMDVMVMSSNEFGEVSEPFVLHRGASSTMPQKRNPISSEVVLAASKILRANAGLGLDAMVTDFERASGSWHLEWVAVPESFVVAVGALSQMEFAMSGLVVDTKAMGKNLASTRGLIVAERVMMELAGGIGRQKAHDVVYEACRETIESEEEEGRTLCETLCGKKEVMEVLKRERVEELCEPGNYLGQSREMADVVLKMGEKKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCA8</accession>
    <name>F9XCA8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_104513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852199.1">
        <property type="nucleotide sequence ID" value="XM_003852151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCA8"/>
    <dbReference type="FunCoup" id="F9XCA8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCA8"/>
    <dbReference type="GeneID" id="13393975"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104513"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.385"/>
    <dbReference type="eggNOG" id="ENOG502S452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131037_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCA8"/>
    <dbReference type="OMA" id="MDFNCSK"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="99" mass="11006" checksum="707085D4361CA603" modified="2011-10-19" version="1">MLTKYLTSVTTTFSPFNPRSGKTARNFLALLPPNARSTMAISITMLPKAQAATPASLAIKFKDGKEMQLDLEKLRIKDIETEVDRHSRSLRRAEDLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCT7</accession>
    <name>F9XCT7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851392.1">
        <property type="nucleotide sequence ID" value="XM_003851344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCT7"/>
    <dbReference type="GeneID" id="13401375"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104754"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.156"/>
    <dbReference type="HOGENOM" id="CLU_1769543_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCT7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395603" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="163" mass="17542" checksum="9DC10150B59B9F8B" modified="2011-10-19" version="1">MKIFTLLSFLLPLCLALVVPKSNTDGSDYALILAPRQAGAVVEATIEATFEFVFEEAGGQGATEEAEVIITTEGNTGRNAAAAGYAPSGTSITGSKFEKFGTRFFFRKFDEFTGFEGSGNFLYDHASHKISEWGVDSAVIKRPGTTLRQIKGTRLSLTKVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCW1</accession>
    <name>F9XCW1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_44190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851404.1">
        <property type="nucleotide sequence ID" value="XM_003851356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCW1"/>
    <dbReference type="GeneID" id="13393700"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44190"/>
    <dbReference type="eggNOG" id="ENOG502R9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066042_4_1_1"/>
    <dbReference type="InParanoid" id="F9XCW1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="21144" checksum="C24E4F67C9162C7F" modified="2011-10-19" version="1">MSVYGVVLVLTAAFVALLLLKIPLDLRSRSDGRRAPAAGQDHFHCGNSSAQALKAGCTFDQLLWAWLPPDCPEYANQEFMKAGDWRYYLDPLGKQRATGASWTAAMDNEINLWGEKGEHLSHCVFMFLSLGRIVHDGTAYPPRLVSNEHLDHCAEYLLEALRKGDDWQTMENSVGKVSYEEYCFRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCZ5</accession>
    <name>F9XCZ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_81123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851908.1">
        <property type="nucleotide sequence ID" value="XM_003851860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCZ5"/>
    <dbReference type="FunCoup" id="F9XCZ5">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCZ5"/>
    <dbReference type="GeneID" id="13401406"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81123"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.208"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCZ5"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="149" mass="16772" checksum="778CBB97E100F859" modified="2011-10-19" version="1">MPTRLTKTRKHRGHVSAGHGRVGKARKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRYFHKLQNQFWKPVINLDKLWSLVPIEQREKYLANKSADTAPVLDLLPLGYSKVLGKGRLPQVPIIVRARYVSKDAERKIKEAGGVVQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDJ0</accession>
    <name>F9XDJ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPT3, positive regulator of Ty transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MgSPT3</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_43318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851817.1">
        <property type="nucleotide sequence ID" value="XM_003851769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDJ0"/>
    <dbReference type="FunCoup" id="F9XDJ0">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDJ0"/>
    <dbReference type="GeneID" id="13402181"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43318"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.411"/>
    <dbReference type="eggNOG" id="KOG3902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038706_1_1_1"/>
    <dbReference type="InParanoid" id="F9XDJ0"/>
    <dbReference type="OMA" id="QFMFNEQ"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="324" mass="36663" checksum="B3887183D08A94C0" modified="2011-10-19" version="1">MAENKAKYRTEIQQMMFVSGETGDPAAETTMMIESIVQQQVMEMLKRATDLAARRGVRTISTDDLIFLIRQDKAKVSRLRTFLSWKDVRKSAKDSDDKGGGGGDAGGVDDFDLAANDPTLGSGPAVGTRNNKNKKAKVGLPWDVSSFYSEQVPEREDEEDEEEEEMNAATLQRLKQADERTKGMNAEEYLHFSECRQASFTFRKGKRFREWAGFGVVTDSKPNDDIVDILGFLTYEIVTLLTEEALHVKAAEDALKRESGGDEEKRGRKRRREPGLFDPPEEARTPVSAKHIQEAYRRLQKPELKSRYMSHVPKGAWQRPLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDY1</accession>
    <name>F9XDY1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_73424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851746.1">
        <property type="nucleotide sequence ID" value="XM_003851698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDY1"/>
    <dbReference type="STRING" id="336722.F9XDY1"/>
    <dbReference type="GeneID" id="13401732"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73424"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063727_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDY1"/>
    <dbReference type="OMA" id="KRNIWSW"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="288" mass="30997" checksum="C7217950043C9CD5" modified="2011-10-19" version="1">MIEPSIRLRRAIHLNDASLVSRLLRSHPRLLSNPDFSSKANTSLHLAASHGFTTIATLLIDAGHDGDEISRNADHNTPLMLAAQAGHVETATFLAVRFPRSIHYRNKDGLDALALATQNTASTGLIPTLLSGNGIYYADMESRDNEGNTPLHHASASGGLKALRLLLDAGADPTARNFYDWMPVAYSQTVAAEVYFRNLVAEYERRKMIEAEQRESGKVGIRAGAVRLVMDDEGSGGTAEDDVMSKQAWSPSGERRRPPTPPGVRGGGDWGAATIAMVRTRSGSGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEC2</accession>
    <name>F9XEC2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_104715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851984.1">
        <property type="nucleotide sequence ID" value="XM_003851936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEC2"/>
    <dbReference type="GeneID" id="13393761"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104715"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="InParanoid" id="F9XEC2"/>
    <dbReference type="OMA" id="LPTIMFA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="620" mass="68524" checksum="1CB22ACCA1C5A4A2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEK5</accession>
    <name>F9XEK5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_73576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851683.1">
        <property type="nucleotide sequence ID" value="XM_003851635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEK5"/>
    <dbReference type="FunCoup" id="F9XEK5">
        <property type="interactions" value="1221"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEK5"/>
    <dbReference type="GeneID" id="13401895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73576"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.697"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEK5"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="357"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="448" mass="50516" checksum="5CDDD66C1A2C5345" modified="2011-10-19" version="1">MKIKALTRSSSSHQAPGSDVARQPRNLDPALHPFERAREYTRALNATKMERMFAAPFVAQLGRGHVDGVYTLAKDPHSLDRIASGSGDGVLKVWDLPSRDEVWQTQAHENLVKGMCWTQDRKLLSCGTDRTVKLYDPYNSPSNSKPAATWLGSNAFTALSIHRHEPAFAAASSSAIQLYDLSRPSTTPTQTLAWPTSIDTITALAFNQSETSLLASCATDRSLVLYDLRTSSPLHRSILSMSSNSIAWNPIEPFNLAVANEDHNIYMFDSRNLSRALNVLKDHVSAVMCVSFSPTGQELVSASYDRSIRLWTPTKSGHSRDIYHTKRMQRVFSCTFTGDSSYLLSGSDDGNIRLWRANASDRSGIKSARERQKIEYDEALKERWKHMPEIRRIGRHRHVPKVVKKAGEIKGEELRAIKRREENERKHSKKGLQKRRSEREKMILATEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEP6</accession>
    <name>F9XEP6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ca2+-dependent lipid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_73692</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850599.1">
        <property type="nucleotide sequence ID" value="XM_003850551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13401106"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73692"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="InParanoid" id="F9XEP6"/>
    <dbReference type="OMA" id="WAKFGKV"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="341"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="579"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="800"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP85575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144143" checksum="951F8159AFC1A626" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XES7</accession>
    <name>F9XES7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MgAMN7</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_86746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003850565.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XES7"/>
    <dbReference type="GeneID" id="13401089"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86746"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_1_1"/>
    <dbReference type="InParanoid" id="F9XES7"/>
    <dbReference type="OMA" id="TEHAWTM"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP85589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="56116" checksum="302426EC80339158" modified="2011-10-19" version="1">MQRSWDAYRRHAWLADELLPVSGGNKTAFGGWAATLVDSLDTLWIMDLKEEFQEAVDSIVQIDFTATTQKSINVFETTIRYLGGFLSAYDLSDDKRLLDKSLELADMLYAAFDTPNRMPILRWDFHAARKGEEQVASDHVVLAEMGSLCLEFTRLSQITRDPRWYDAVARVMDVFRDQQYQSNIPGMWPLIVNGRDMEFFSKHSSQVFSIAALGDSVYEYLPKMYALLGGSEQYAAMFNGAMNTLMKHSLFRPMTKQGDVDALVPGALRFLEEKITVQAELQHLSCFSGGMFALGGKLLQNDSYVAIGRKLTDGCIWAYDNFPTKIMPEVSNVVRCKDDASCPWDEDEWNRAVYDLAPFEIKDSTNSSELIKNNRLPPGIASIPDPGYRLRPEAIESIFINYRVTGDESLQDTAWSMFKTVYAHTRTEFAHAAMKDVTNGTAPMEDSMESFWTAETLKYYYLVFCEPEYVSLDDYVFNTEAHPFRRPEYVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEZ5</accession>
    <name>F9XEZ5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine protein phosphatase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PTP6</name>
        <name evidence="3" type="ORF">MYCGRDRAFT_45401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850620.1">
        <property type="nucleotide sequence ID" value="XM_003850572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEZ5"/>
    <dbReference type="STRING" id="336722.F9XEZ5"/>
    <dbReference type="GeneID" id="13401082"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45401"/>
    <dbReference type="eggNOG" id="ENOG502S8V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_2_0_1"/>
    <dbReference type="InParanoid" id="F9XEZ5"/>
    <dbReference type="OMA" id="LSWWDFF"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
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    </dbReference>
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        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="265"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="387" mass="42822" checksum="393DE5EAD260CB21" modified="2011-10-19" version="1">MQNLVWVDDLEYHREDEPCAGFEQIKASTLHGRVDLCCSSRRSSIAIKPHFLLASTSDIRPRDTPGLNLHPAVHGEHQNVSPNSEQRTPSFSRIANFRDVAISTGKTPSQALLKPGFLFRSAAPDDATPSDQRRLTDDFHIKTIIDLRTDSEHAALLAKEKKSPFPPADVPDFDIPSDGPSSTPPPSGSNNGHKIPGIKYVNVNFNGKTYSSAMFSRLSYYHRAKLIALYITGYRPQAISIIGKNVMSQRGLIGLAKDSLAHCRAEIAQVFEVLSEEGNWPVLVHCTQGKDRTGLVVLLVALLVGVGMEDVKRDYLLSREGLEGDREERVKAVREMGLTDEFAGCEEGLVEEVVTELKERYGGVEKYLEGCGVMREKQRKVKEILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFD4</accession>
    <name>F9XFD4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_81517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851206.1">
        <property type="nucleotide sequence ID" value="XM_003851158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFD4"/>
    <dbReference type="GeneID" id="13397946"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81517"/>
    <dbReference type="HOGENOM" id="CLU_2591619_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFD4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="9050" checksum="ACCCDC6378A2464E" modified="2011-10-19" version="1">MTEILGVQGLTLELIRGEAGPKREIWLHVPQPPGACTQRNGCGSTRQESHQKYEQYKREPGETESGLLRERVDLVFCILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFQ1</accession>
    <name>F9XFQ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_15548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
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        <property type="protein sequence ID" value="EGP85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFQ1"/>
    <dbReference type="GeneID" id="13397430"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15548"/>
    <dbReference type="eggNOG" id="ENOG502S329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030506_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFQ1"/>
    <dbReference type="OMA" id="CFAGTQY"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="286" mass="31704" checksum="C6FF2BB554B40FBE" modified="2011-10-19" version="1" fragment="single">TVLYLAYGSNLSIEKFRGARGIKPLSQINVQVPSLRLTFDLPGIAYNEPCFANSARRDSKNDHPRNDATSEKTRLLGERSRTRGYRKEAWHKGLIGVVYEVTPEDYAHIIATEGGGASYHDIVVDCHPFASSDVHHPVPQVPATPSFKAHTLFAPAIPPGEEPPTDGGRLTRPRPGYAQASARYLKLITDGAAELGLPMEYQRYLLAIRPYRVTMVKQRIGQASFAALWMPLVFLLFGLSNMFSDKNGKVPAWITGLLAFIFKAAWRSYDVVFLPVFGDGERTIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFQ6</accession>
    <name>F9XFQ6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850695.1">
        <property type="nucleotide sequence ID" value="XM_003850647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFQ6"/>
    <dbReference type="STRING" id="336722.F9XFQ6"/>
    <dbReference type="GeneID" id="13397433"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45223"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.318"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="InParanoid" id="F9XFQ6"/>
    <dbReference type="OMA" id="FPLEKHM"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="378" mass="41598" checksum="DF38863AC5055D12" modified="2011-10-19" version="1">MSTIDQETHIFITGGSGFLGQYIIKAILERHPKWRITVLDLVPPPPALLSVIHNFHHCDITSPSSLTTAFSTCPIPPSLVFHTAGCIPSGALRYSTSSTQWQKVKNINYHGTQNVLSALLASGCTRLVYTSSCTVLQDDLLNSHPNTTESIPIAGRASVHYGRSKALAESHILNPNHRKNHALLACALRPCTLIGKGDTAVMKPMHSLIAERSTNFILGKGDNLYDFMCVENAADAHLLAAENLLSSNPTAAGEVFFVSNEEPVYFWDFLAAVWAGFGHVPAWRIHVPFWLALVFGFLAEMIGWVVGGGVAISRGSVRDSVRTGYADCGKARRVLGWEPRVRLREGVKRWVEGYKEVLREREEVKRDNGRSGSGKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG98</accession>
    <name>F9XG98_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_24521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851069.1">
        <property type="nucleotide sequence ID" value="XM_003851021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG98"/>
    <dbReference type="FunCoup" id="F9XG98">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XG98"/>
    <dbReference type="GeneID" id="13397514"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_24521"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_4_0_1"/>
    <dbReference type="InParanoid" id="F9XG98"/>
    <dbReference type="OMA" id="FWFTCAN"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035356">
        <property type="term" value="P:intracellular triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP86045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="339" mass="38461" checksum="024DCF1E88E58F83" modified="2011-10-19" version="1" fragment="single">RSAIRWAPLNVPVQRRLQTVMVLVHTLSIAGGLALFLLLCAIPILWPIVIPYMLYCTFSRASINGELKQRSEWCRKSKIWSLFGSYFPARLHRSQELEPTRKYIFGYHPHGIISHGAFAAFATEALGFGQLFPGITNTLLTLDSNFRIPLYREYALKMGLASVSRESCENILSKGGPNGEGMGRAITIVVGGARESLDAIPYTLRLVVKRRKGFVKLAIRQGADLVPVLAFGENDIYDQFDSAAHPWIHKGQMAVKKLMGFTVPLFHARGIFNYDVGMMPYRRPINIVVGRPIRILQDKNPDQAYIDEIHGKYVDEMLRIWEEWKDTFARNRKGELEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGC7</accession>
    <name>F9XGC7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_105030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850561.1">
        <property type="nucleotide sequence ID" value="XM_003850513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGC7"/>
    <dbReference type="STRING" id="336722.F9XGC7"/>
    <dbReference type="GeneID" id="13401144"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105030"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.14"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="F9XGC7"/>
    <dbReference type="OMA" id="NVEWIVE"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391642" evidence="3">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="28246" checksum="506780533B998B55" modified="2011-10-19" version="1">MKLCVVTSGLLFACLAAAATPPNSGLRSSERRQAGRRSELRPRGSGVAPGPDDSGWAGAIHSGKDITEVSGTFIIPQLSRPPNADADTTYVGSAWLGIDGDENCPGAILETGIDFFASPDGSIEVDAWSQWTPGYQYSFQSLKNLEAGVELHFHVKTNGATGGTAQIYVPSTDETWTQTYTDQPALCQTSAEWVVENLLTTDANGIRTIPPLIDFSDLTFTGAKYTHDGGVQSGAAGSRPQAINVGGVVRAAGQAVGEDSVVIKYHASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGF7</accession>
    <name>F9XGF7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_86707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851296.1">
        <property type="nucleotide sequence ID" value="XM_003851248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGF7"/>
    <dbReference type="GeneID" id="13401128"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86707"/>
    <dbReference type="HOGENOM" id="CLU_2672996_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGF7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="75" mass="7936" checksum="B45FB38C73172D18" modified="2011-10-19" version="1">MISRGARALPFRAPSANIILPSSIINNRHIAASSDRNGEGCCSGSKLFIGSCAEVQPEHLSAEWTSQAHICVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH43</accession>
    <name>F9XH43_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_110613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850174.1">
        <property type="nucleotide sequence ID" value="XM_003850126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH43"/>
    <dbReference type="FunCoup" id="F9XH43">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH43"/>
    <dbReference type="GeneID" id="13394585"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110613"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.691"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="InParanoid" id="F9XH43"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="249" mass="27648" checksum="80B4F8257C478FB7" modified="2011-10-19" version="1">MASEGQPSPVIRAPSQQLGPDYKTSTDRPTATVSTNPKIHNLHILPQTPQLIALLTMLRDKTTGRADFIFHSNRISRLLVEEALNHLPVLPHTITTPVGRTYAGVEFEGKICGVSIMRAGEAMEQALRECCRSVRIGKILIQRNEETSQPQLFYDKLPEDIKNRWVLLLDPMLATGGSALMAVDVLLSKGVPEERILFLNLIASPEGVQNFAEKFPKVRVVTAFVDQGLNEKNYIVPGLGDFGDRFYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH89</accession>
    <name>F9XH89_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849989.1">
        <property type="nucleotide sequence ID" value="XM_003849941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH89"/>
    <dbReference type="GeneID" id="13402783"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95080"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.271"/>
    <dbReference type="HOGENOM" id="CLU_918917_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH89"/>
    <dbReference type="OrthoDB" id="10299972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="303" mass="32974" checksum="3FF1CB005CCE8F07" modified="2011-10-19" version="1">MSSTTHNCTECSVSTPSLVIATNHVNASNQNKRQWRCPGCSTRFCIKNDLVNHTPNCDRFNTWRRTIKWGKDLSNARVSAACDFTEQRAGAVAQVTSSTTQASQIVAPPAMQSTSTNDNDDNGKQRPNRSRKLAAEEKLSDEEDAEGHEGTAPKRSRRSGKSTATLKPMPQSGLKSTMDSSAAPTGPGAFGGEVEEHVWTTLDDGDEENLGDVDWNGGFDFGGWEEAPLLPALETRVSTMTNVHQAMTEANRIDYSGDGGYGRPQPEWNRSRFGPSGITEFAEYVEESRKKANAKAANTPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHJ2</accession>
    <name>F9XHJ2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850015.1">
        <property type="nucleotide sequence ID" value="XM_003849967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHJ2"/>
    <dbReference type="GeneID" id="13394988"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95126"/>
    <dbReference type="eggNOG" id="ENOG502SXKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422482_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHJ2"/>
    <dbReference type="OMA" id="PLHTILC"/>
    <dbReference type="OrthoDB" id="4158258at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="191" mass="20917" checksum="3BF64736ED1E3D55" modified="2011-10-19" version="1">MADFKSIPTLASNNPYAAQQKRRANSVPLATIPAASAPNATTDGSSTPPKRQDSMFNTDTTSRSQSPVTAPPQPTLVTRHYSIGTVPVAYTSTMPTGGLMRSRTYGMGSPVIDRANVPLSDDDIIIVTVKLTNRFRKNSITGAEDLPGRLDHSAEKEERYKAVKMPRGEYKKRFIKNADGKYVGTEPEKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHL1</accession>
    <name>F9XHL1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_87144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850023.1">
        <property type="nucleotide sequence ID" value="XM_003849975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHL1"/>
    <dbReference type="STRING" id="336722.F9XHL1"/>
    <dbReference type="GeneID" id="13394903"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87144"/>
    <dbReference type="eggNOG" id="ENOG502QT6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="InParanoid" id="F9XHL1"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="320"/>
        </location>
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        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
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            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
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        </location>
    </feature>
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        <location>
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            <end position="208"/>
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    </feature>
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            <end position="306"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000008062"/>
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    </evidence>
    <sequence length="320" mass="33130" checksum="27D62CFC386D9761" modified="2011-10-19" version="1">MRLPFLLLTTTLLTTPSVLALGGSSKILLSKVKSLTLRSSALTTSRRVPPVPQLTCVGGNAQGLYDVDVMSCKNNGQGYDSEDIHWVCQASLPPEFKLGATDVVCEGYDSAEDPWVLKGSCAVEYRLVLTPLGGMNPSSSYHSPSSSSGGLSDSISTFIFWLFFLGVAGFIIYSVCVNPNNPNRRGGRFGNRNNWGGWGGGGGGGGPDDGTDDPPPPYTPRGPKVRFSPYGSSSAGGANSGPGFWTGTMAGAAAGYGAAAWNARRNQQQQQQAGPSSWFGGGGNAGGQGYGVAGPSNYASAPAPSSSRHESTGFGGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="533" mass="58531" checksum="9C8D2413E0DA71AA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="F9XJL8"/>
    <dbReference type="OMA" id="RMTKMAK"/>
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        </location>
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            <end position="46"/>
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        </location>
    </feature>
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        <location>
            <position position="127"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="127" mass="12531" checksum="DCD4894F20A12949" modified="2011-10-19" version="1" fragment="single">QLAGVGQGCNSVFTEFDNGLGYGIEDAEENTAKLISGKGGSGGSTGGSAPPPPPPPPHHKDRRQLDKISNGFQAISNAVGAGSSTSSLTTELDNLDGTGTSGSAQIGAAIGQGEVDILEGIGKAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK04</accession>
    <name>F9XK04_ZYMTI</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK04"/>
    <dbReference type="FunCoup" id="F9XK04">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK04"/>
    <dbReference type="GeneID" id="13399082"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105721"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.277"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK04"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="104" mass="11205" checksum="15D479EFCE41805A" modified="2011-10-19" version="1">MSTAIKSIKSLAPLLDRVLVQRAKMQAKTAGGIYLPETAVKELNEAKVLAVGPGMMDKDGKRIPMGVSAGDRVLIPQFGGSPIKVGEEEFSIFRDHDILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKR7</accession>
    <name>F9XKR7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_76293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848865.1">
        <property type="nucleotide sequence ID" value="XM_003848817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKR7"/>
    <dbReference type="FunCoup" id="F9XKR7">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKR7"/>
    <dbReference type="GeneID" id="13398035"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76293"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKR7"/>
    <dbReference type="OMA" id="YVIHLFA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="181" mass="20282" checksum="09A4B8ABA357B645" modified="2011-10-19" version="1">MLRTAPLLRQLPATVQSGRTAAATFAPFARQSSLQQTRSAHAISNPTLANIEKRWEAMPPQEQAELWMSLRDRMKVDWNELTMQEKKAAYWVAFGPHGPRAETPPGEGTKVFIYTLMGVGAAGAIFFTSRMFARPAPSTMNKEWQEATNEYLRENKVEPITFIGNPDYKGPGMVQSPPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKS7</accession>
    <name>F9XKS7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848978.1">
        <property type="nucleotide sequence ID" value="XM_003848930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKS7"/>
    <dbReference type="GeneID" id="13398298"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106026"/>
    <dbReference type="HOGENOM" id="CLU_2575687_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKS7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="81" mass="9986" checksum="5EF68B72E4E8A4EA" modified="2011-10-19" version="1">MELRQYVQCWKRRRQNCADPANREHRDFHHRLLQMTLLLAVHHHHPALDHPLAHLVRRDHHRHLLLLLALRLDSDAWYWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKW3</accession>
    <name>F9XKW3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_13719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848997.1">
        <property type="nucleotide sequence ID" value="XM_003848949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKW3"/>
    <dbReference type="FunCoup" id="F9XKW3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="GeneID" id="13398329"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_13719"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="InParanoid" id="F9XKW3"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="209"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39800" checksum="2E74947ADACEE09D" modified="2011-10-19" version="1" fragment="single">DVDHEDYRPPYPHAILAGGLGGTMGDMLMHSLDTVKTRQQGDPHMPPKYTSMGNTYYTILRQEGVWRGLYGGVWPAFMGSFAGTCIFFGCYEWSKRTMIDLGITPSFAYLASGFCADLAASPLYVPTEVLKTRLQLQGKHNNPFFVSGYNYRSSMHAFRTIYRTEGVLELFSGYKATLFRDLPFSALQFAFYEQEQRLAKQWVGPGKEIGMPLEILTGASAGGMAGVLTCPMDVVKTRIQTELDPELAAAAREKRSAMKAKSAAVKASSSSSSTTRPSTASPASSSSSSQTRSISTSGPSTALKHHGQVPLDTESVIKALRIIYRTEGVGGWFRGVGPRFVWTSVQSGTMLVVFQKLLRWFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL76</accession>
    <name>F9XL76_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_48880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848894.1">
        <property type="nucleotide sequence ID" value="XM_003848846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL76"/>
    <dbReference type="FunCoup" id="F9XL76">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XL76"/>
    <dbReference type="GeneID" id="13398139"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48880"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="InParanoid" id="F9XL76"/>
    <dbReference type="OMA" id="YLYSPGN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="178"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="55843" checksum="502A6AAE82A7EBD6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLD4</accession>
    <name>F9XLD4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_76143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848808.1">
        <property type="nucleotide sequence ID" value="XM_003848760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLD4"/>
    <dbReference type="STRING" id="336722.F9XLD4"/>
    <dbReference type="GeneID" id="13398653"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76143"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.155"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="InParanoid" id="F9XLD4"/>
    <dbReference type="OMA" id="CWALRNQ"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="181"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="385"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="465" mass="52279" checksum="18F34F935F9B5ADE" modified="2011-10-19" version="1">MSQRDPDLHNAISLRPMPFQHTYAADHHRSSSRIQTPEPAQSSSSPTKPGASSAVEPLPAVSGAHERPAYHRNSSDSDRDDVERQNSLPGYEATNDPFKLRESIKNIEDEKKARANTKAKRVCQPISSGQEKVKSHKIIKFYENQNDKIERLLKPVDDHVREAKEQEGADALQFKIAVNGSFAANIILAILQIYGAAASGSLSLFTTMADAIFDPLSNLTLILCHRAVNRVDARRFPSGKARLETAGNIAFCFLMTAVSLVLIVMSIRELTDKNHDVKFHYPSVIAVGIAFCTKLALFLYCFSLRNKYSQVRILWEDHRNDLLINGFGLMTSVLGSRVKWWIDPMGAIILSVLISYLWLRTAYAEFQLLIGVSASTSFLQHVTYISMTHDPRITSLDTVRAWHSGPRIIIEVDVVMDKELTLGETHDVAEDLQMKLESLPDVERAYVHVDYETEHSPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLG7</accession>
    <name>F9XLG7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YebC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_48269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849092.1">
        <property type="nucleotide sequence ID" value="XM_003849044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLG7"/>
    <dbReference type="FunCoup" id="F9XLG7">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLG7"/>
    <dbReference type="GeneID" id="13398159"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48269"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.362"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_1_2_1"/>
    <dbReference type="InParanoid" id="F9XLG7"/>
    <dbReference type="OMA" id="NFDIPDE"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33588" checksum="59D9F872AEF2AB85" modified="2011-10-19" version="1">MAPSRGYSALVGVHNIFAAYRGCPSRTLATIPARQSAVYHRSPSRLFATTASLRSGHSRWSKIKHDKAKVDASKNRQRSIFAHEIATASKLFGGDPGSNPRLADLITKAKREGFAKASIEAAIARGQGRSTTGASLESVSVEGILPNNIAIIVECETDSKLRTLADVRLAIKDHGGSTTPTSYLFAKRGKITFESKEGIGQDEILEPALEAGALDVAEDDGKRVVVFAEPTETRAVGDAISKALDVQIATSDIIWEANEDTKVDIASEQAADDIHAFLDKLEEKEASLQSVAMNVSQGRLSADSWEDIKSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLY5</accession>
    <name>F9XLY5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_48331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849035.1">
        <property type="nucleotide sequence ID" value="XM_003848987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLY5"/>
    <dbReference type="GeneID" id="13398432"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48331"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.483"/>
    <dbReference type="eggNOG" id="ENOG502QSYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_1_2_1"/>
    <dbReference type="InParanoid" id="F9XLY5"/>
    <dbReference type="OMA" id="EWIHESV"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="3"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="494" mass="54625" checksum="BB83C9DA57C4D7A8" modified="2011-10-19" version="1">MPKRLVLAIDGTWVNADNGYSPTITGPPANHTLATPSNVARLCRALKTRDGTDPSIEQIVYYQGGLGSSANWYSYVFGGYLGDGIDAAIREAYGFLANNYEDGDEIFLFGFSRGAFTARSVGGLIASIGLLTKEGMESFYPIFMDWEYQNDPSYVNGYSTPVWPQPNQERPKMDSKDTYFNALKAAKLTQPTIPTIKAVAVFDTVGSLGVPDVKPLGIKLHHSSKAEYSFVNTQVAPNVENAYQALALDEQRSAFVPTVWESPKGGKETHPVFNELRQCWFPGVHTSIGGGYQDTSIANLTLAWMMTQLSQYLDFDPEYLRRQIKQNQAFYTDKKVPENSPSRDYAMGLIKSSDVGLLNTVLGRVTRTPGTYQLTDPNTGEPLPERLQKTCEFMHPSVRWRMQQRGPGLAQTKTDTIGQGVYTPLALEKWKFFAAGEETPKGVAVEAMWAKKGKWVNEELSVYVVEDEVEQGSWEEILVGAYGKEAVAFVTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XM03</accession>
    <name>F9XM03_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848423.1">
        <property type="nucleotide sequence ID" value="XM_003848375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM03"/>
    <dbReference type="GeneID" id="13396177"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96753"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.382"/>
    <dbReference type="HOGENOM" id="CLU_866552_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM03"/>
    <dbReference type="OrthoDB" id="10374275at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="321" mass="36479" checksum="648C12D831F69604" modified="2011-10-19" version="1">MWPARLTEGYSANLSTPGYSTNQVARRPGQIMTADQRANNAHNGSVLREIELLAGNLGLRAVLTPRQLSALNKDAETWTTPVLDTILQLVKTVVHESLPGVQNAAAEHFIQEARAWMMDEEVAKELHPLGAGDVQEAVKRCQVEYADKKVAEGQQMMREYHLLEAHKKAIQDTLEIFKKSITDCSSNFEEVWHDIEFEVNMRHGILTHDLRQWLQEQFYELWEQARPLPPRKYTFRSLNPMMRAKGPRAKLKVTWEIPPGGTYDKSTGRITYESRHSFEEVYGIDGATKRTGNHDTQPIEIEHLSTKVVKVRLNGNPGVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMB7</accession>
    <name>F9XMB7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_23191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848477.1">
        <property type="nucleotide sequence ID" value="XM_003848429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMB7"/>
    <dbReference type="GeneID" id="13396202"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_23191"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="F9XMB7"/>
    <dbReference type="OMA" id="ASTWFPK"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="230"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="430" mass="46580" checksum="636FDF118E9F291D" modified="2011-10-19" version="1" fragment="single">SEPVWPTDWRAYTCLFGGFLLMFNSWGLVNTYGTYSSFYMQHLLPGRDILLLNLVGSTQSFVVLILSAVVGRFLDAGYSRTLMIVGTIFVSIGSFVLSAVNGNAEYNDGNYPLIWLTQGFLTGLGMACFFVSSSQVVATWFKAKKGFAIGVVASGASIAGLLYPMMTKFLIQKQGFNMATRYVAVVVLLTSALAVIIARPNPAHQIRKPDTWFKVSIFWDTYAFHNHAYSFLVAAIAFLFFGFYAVFFNLEEWAVEEGFGYRKAINTGVNAGINARPPRNSIETFWLLSIMNATSTIGRLGSAYLCDHFGALNVHAIVTAVASILVLALWSLASTLPSAIAFVVIFGAFSGAVIGLPPASVAYILGPTPEAQAKLGQWTGMMYSCAAIFALTGPVIAGHLITEYSTFLTVQLWSGACMMMSAACMAGAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMD6</accession>
    <name>F9XMD6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_96868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848489.1">
        <property type="nucleotide sequence ID" value="XM_003848441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMD6"/>
    <dbReference type="GeneID" id="13396211"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96868"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.528"/>
    <dbReference type="HOGENOM" id="CLU_1688133_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMD6"/>
    <dbReference type="OMA" id="CVAYDPP"/>
    <dbReference type="OrthoDB" id="10482381at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51895">
        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395567" description="AA1-like domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="156" mass="17037" checksum="98CA0B31668836C5" modified="2011-10-19" version="1">MQSIIATSILAFFASSAIAALPDRSSYNIENFSETKSLDNDITSVSFDITPYDPATTSGSGGVYHCTQYDVVTGELVANFEEMTTYSCGPGSPFSFSYSEKDGPFKYRLYMWQEATPQTPTRWAFTPIRAPACNTADGHQICYAPDSLITLTNDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMN0</accession>
    <name>F9XMN0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_63510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848303.1">
        <property type="nucleotide sequence ID" value="XM_003848255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMN0"/>
    <dbReference type="STRING" id="336722.F9XMN0"/>
    <dbReference type="GeneID" id="13396112"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63510"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_1_1"/>
    <dbReference type="InParanoid" id="F9XMN0"/>
    <dbReference type="OMA" id="KPWAKVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33444" checksum="84ADAC327FB6BF20" modified="2011-10-19" version="1">MTTSTFKHIDPTSSPSKPWSKVDGPGQSFKYLDIPRTVHNLRGRESEFNTNNCGFAVYNSPAKEKEFVDDKAVREGYYPEVEGLLKKNLEGVSKVVIFDHTIRRRTKDSPRQPVQQVHVDQTPAAAAVRVRRHLPSDEAEKLLKGRYQIINVWRPIGNPASDFPLAVIDWRSTRPSDFIDIDLMYPIRPDSAMDDDDRGKEKLPSEESLNSTEGYEVRGETMGVAASEKHQFYYMKDMGVDEVMLLKCFDSFGEGMEGGKPGIAVRTPHTAFVDPNTPKDAPGRQSIEVRCLVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN33</accession>
    <name>F9XN33_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_76868</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848367.1">
        <property type="nucleotide sequence ID" value="XM_003848319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN33"/>
    <dbReference type="FunCoup" id="F9XN33">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN33"/>
    <dbReference type="GeneID" id="13396514"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76868"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.260"/>
    <dbReference type="eggNOG" id="ENOG502QWI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN33"/>
    <dbReference type="OMA" id="EIRPGNF"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="332"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="465" mass="50402" checksum="731C1F679B742F73" modified="2011-10-19" version="1">MVSSFTAPSFYPSSHVPSLQAEYIGKSLCDINPPAAILDAAVLRRNCKRMLTATQTLGVGFRAHVKTHKTTQLAELQVGKDSKSVNLIASTVAEIENLAPWLLECQSQGKTTSILYGVPLAPSTIPRLASLARILGPGVLGIFVDHADHVKVLSEVDESTWPGRIPIWVNIDVGYHREGVPSDSKQLADIAYALSASKRVTLGGIYAHMGHSYGVSSPGEALSFFGQELEGLEQGAISFLKCTDAHATNDPNAEKIVLSLGATPTARAIQNLLSGEATESTKAYRSTLDRINRSFTVEIHAGVYPVLDLQQMATRAASSGPGASETSYDDIAFRLLVEVNGAYPERSEKPEALIAGGCILLGREACKSYPGYGIVTPWPAQEGRFYDPAGSKTGWIVGKVAQEHGNLWWEGPAENVRPLEIGQKLMLWPNHACIAGAHFGWYLVVDSEEEDPEVVRDVWVRWRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN48</accession>
    <name>F9XN48_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_101591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848599.1">
        <property type="nucleotide sequence ID" value="XM_003848551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN48"/>
    <dbReference type="STRING" id="336722.F9XN48"/>
    <dbReference type="GeneID" id="13396404"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101591"/>
    <dbReference type="eggNOG" id="ENOG502SM12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_1"/>
    <dbReference type="InParanoid" id="F9XN48"/>
    <dbReference type="OMA" id="YERRWRP"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="453" mass="48686" checksum="A8FDA4F9550FF915" modified="2011-10-19" version="1">MPPPPPPRRILIVGGGPAGAVAAYHLAKSGLQVLILERSPSPTTSTTRGQGIDITGPAISVIRRMELYDVVRANCTGEKGFSMLDDSGKVIGRLPAADQTDGGKGGLQLTQELEIMRGNITRILASAAQSLSSSQSSAGDGNGKGGVEYRYGSWLTSLSQSSSSVTATLSDLDGEETTVSFLAVIGADGMNSTVRRLAFSPEVTRNCYRPIGSQWTAFFSIPAEERDGEDSVLQQGVGCRTVLIRPIQGRMCSCYLVKTSHSPELAKSATKPRQQALQKEIFTRLFASFPGSLRSRVLSGLRTTSDFYVAQTAQIHLPTWSSGRVALVGDAAYAPSPVTGQGTAIAIVGAYILAGEMAKTPEDVEGAFERYETVFRGYVEKAQRIPGGARIPRLVNPETRWGIEVLRWVFWVVATTKVYRLFGGWGGGKKEGWRLPEYDFAAVGHTSEEQETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNY0</accession>
    <name>F9XNY0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_101782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847975.1">
        <property type="nucleotide sequence ID" value="XM_003847927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNY0"/>
    <dbReference type="FunCoup" id="F9XNY0">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNY0"/>
    <dbReference type="GeneID" id="13401611"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101782"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.287"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="InParanoid" id="F9XNY0"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15892" checksum="C4BF629144003BA5" modified="2011-10-19" version="1">MGKGKPRGLLAARKLRNHRREQQWADLHYKKRLLGTAYKSSPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGCKGKAKGDIPGVRFKVVKVSGVGLSALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPB7</accession>
    <name>F9XPB7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_82936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848048.1">
        <property type="nucleotide sequence ID" value="XM_003848000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPB7"/>
    <dbReference type="STRING" id="336722.F9XPB7"/>
    <dbReference type="GeneID" id="13396047"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82936"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_7_1_1"/>
    <dbReference type="InParanoid" id="F9XPB7"/>
    <dbReference type="OMA" id="DMVAFNF"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391624" description="Phytocyanin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="15930" checksum="66394A5B6CD232A2" modified="2011-10-19" version="1" fragment="single">MHSTLSIASVLAVLAGQTLAVTHMVMTDGIAFSPSSVSNVASGDEISVTFSTQIPHNIISSTFDAPCTYNEAGGVASLTYKKGEVFVFKVNSTDPQWFYCSVGDHCNEGMIFAINPSSTETVEEAQNKAANADITLANNEVAIGGAVGGSGSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPM3</accession>
    <name>F9XPM3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_77672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847514.1">
        <property type="nucleotide sequence ID" value="XM_003847466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPM3"/>
    <dbReference type="STRING" id="336722.F9XPM3"/>
    <dbReference type="GeneID" id="13401465"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77672"/>
    <dbReference type="eggNOG" id="ENOG502SJFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062856_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPM3"/>
    <dbReference type="OMA" id="EHWTYWD"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="238" mass="26498" checksum="C5B359387F04F1F6" modified="2011-10-19" version="1" fragment="single">MPNTKIVHVPHLGGIDAAYQMPQPYDSSKPTLVLVNSFTTSSELYRSQYANKDLTNAMNLIAIELLGHGQTRTKSENFTYWDTAIMNLQVLDALKITGKIFVLGTSQGGWITVRMALLAPEKIAGIIPLGTSLDNENSHTVSLGCWDGPGLLKDNISTWTTNTPTSSFEPDTAYCDFLIDIGFGKDVDKDTREYWRQTIKANYQGDDGRRRIRMAAINLADRDGLHSRLSDVRCPVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPR2</accession>
    <name>F9XPR2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847805.1">
        <property type="nucleotide sequence ID" value="XM_003847757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPR2"/>
    <dbReference type="GeneID" id="13400768"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97289"/>
    <dbReference type="HOGENOM" id="CLU_824407_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPR2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37689" checksum="BDFC722FA5FCD591" modified="2011-10-19" version="1">MCTSVTSSAWEPCKDFRVRGNSTFREMLVVNSRFFINQHHKMSNRKREGGVDDDGGGDAAREMRAVDEEEYSQMLRTVLEKTKALCIEREELIVWLEQHGIPVPARLTQEELDATLADLSRFADGEKVEAFGIVPAASAAEPNSAPTVMSKIVEKEVSAPKTAVTSTTNVVKSCPSYWIWGECQMKQPCKMSHDVLKLDLMQSKAYKEACRTGHMAAKTAMLLFDMNEQFRECGFRKEVYKGALANASVASATSVSQHGSPEDALGESEKLSALQDWISEWRTVWFVKMPERVKQRVELVKQGRRPKRGIILLPDDDSAESSQNKGDGANIAYTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPV9</accession>
    <name>F9XPV9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_15571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847788.1">
        <property type="nucleotide sequence ID" value="XM_003847740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPV9"/>
    <dbReference type="GeneID" id="13400787"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15571"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_5_1_1"/>
    <dbReference type="InParanoid" id="F9XPV9"/>
    <dbReference type="OMA" id="DYHGYRR"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP82764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="220" mass="24768" checksum="D758AAE7CA5DDE06" modified="2011-10-19" version="1" fragment="single">VSFASQFGQPIEYPFVTGIPNHPEVIEVSKKATDTGSNFGGVWHSDTTYLSDPPMGTLLQALEIPPFGGGDTMFANQYAAYESLSPALKGILDGLKCIQSSAKADTTKTREDRVKDSGKGSGDLEEVHPVVRTHPETGRKALYVNVAHTTRFEGWTEEESRGLLEFLWKMQVRMEFTCRVRWRPGMIAFWDNRCTLHYPLNDYHGYARRMHRITLAGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPY2</accession>
    <name>F9XPY2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ERG4</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_77785</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
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    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XPY2"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77785"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
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        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="6" id="KW-0521">NADP</keyword>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
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    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82754.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="643" mass="73191" checksum="FF718DF2567B6FB7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ23</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="13401007"/>
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    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="291" mass="32592" checksum="DA57554A125EB564" modified="2011-10-19" version="1">MDYDDTSGFNIRGRAHQNNTERSSSPARRDQYRRSRSPRGYQDRGGYRGRYQDDDYRRSDHGGYAGRQQSYRRRDDRDDTVVERPPTPEEWPPASMNGDSDVATSGQPLQFLLIRDLKPNVTSAILSKGLEKLYRDEVQAGVQEKPQINSNLGATPGSLKRVFIVRESGTSRSLQFGFAEFHSKVDATAALAKFDERRAPLTIASKNIQVNLPHAGIFVPADPSDREAFELRQGDFRKYRAPGYFADAFYPGGKGKHGPPDCQPRARASTCGRSMAEVRRTASPRSSTPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM4</accession>
    <name>F9XQM4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_11476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847409.1">
        <property type="nucleotide sequence ID" value="XM_003847361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQM4"/>
    <dbReference type="STRING" id="336722.F9XQM4"/>
    <dbReference type="GeneID" id="13400356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_11476"/>
    <dbReference type="eggNOG" id="ENOG502QW3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011937_4_1_1"/>
    <dbReference type="InParanoid" id="F9XQM4"/>
    <dbReference type="OMA" id="ECISAMI"/>
    <dbReference type="OrthoDB" id="5426797at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="557" mass="64259" checksum="2AC696A89C4E5038" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR26</accession>
    <name>F9XR26_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_51688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847386.1">
        <property type="nucleotide sequence ID" value="XM_003847338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR26"/>
    <dbReference type="GeneID" id="13400136"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51688"/>
    <dbReference type="HOGENOM" id="CLU_1499889_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR26"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="180" mass="20463" checksum="585AD16355E118B9" modified="2011-10-19" version="1" fragment="single">SPSRHRTLTTSHPPDIAPSRHYTLTTAHPYDVSPSRRLTLATSHPRDISPSRHLTLIASHPPDIYLRTNPVRSQSSNDRATPQQLLQAHSTCTYITRQSPDLKPIRTWSLKHEEAPVLKPVGSDILEPVEAPALTPIRTRMLKPLETPILEHVEATILKLLETPILKRRYGDRALHNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRE9</accession>
    <name>F9XRE9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847149.1">
        <property type="nucleotide sequence ID" value="XM_003847101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRE9"/>
    <dbReference type="GeneID" id="13399652"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97801"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.28"/>
    <dbReference type="eggNOG" id="ENOG502RB0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023803_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRE9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="30298" checksum="B0CC5C23C61B2355" modified="2011-10-19" version="1">MNPYSLSAIHSRNWHLRSPALLRRQRPYLITSPQPQSKFTILSGPIPPSEQQAGTGKALVLLPTSPPLPLTLPRNNSKAPCSPPVDVTDQEDYAGFLATGERWEDYRCRMISQEDGQDVKQSWLSGYKGGSSVEEGLASAARGLASYLYPGKTLSALHKTQPFQRNSQEVDARRWPSVFDRQQMIAHSTPWRWLEDFDMLKAGAAADCSHDEPQAYVEADQVTEAMLETVRSLSMRKCKRSATAVDAKLAIQQINNLAQADDEKISESRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW72</accession>
    <name>F9WW72_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_106868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855985.1">
        <property type="nucleotide sequence ID" value="XM_003855937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW72"/>
    <dbReference type="FunCoup" id="F9WW72">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WW72"/>
    <dbReference type="GeneID" id="13403924"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106868"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.334"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="InParanoid" id="F9WW72"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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    <dbReference type="Pfam" id="PF07690">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="42423" checksum="EF7E8D1A0DF45947" modified="2011-10-19" version="1" fragment="single">MSSSMFAPAIERLANDFGTDKQTVLFGQMGFVCMLGIGPLFHAPMGETFGRRPIYLTNLAIFTLLQLASALSPNIASFIAFRTLSGFFGSVGVANGGGTISDMFDSKGRAQVLGFYFMGPLLGPCIGPLLGGLLVGSLHWRWVFWLSMLFAGLTTIICFFFLHETRAQSILEQRKSQLSKKHPNTSYTVEGTSDKSTFSKMASNSTRAIKILTTQPIVLTMSIYQALVFSSMYTLYSQYTTIWSSAPYEFTKSQIGLAYLGPALGFIFTSIFIILFIDRLDNWLAKRHNDDAQPEYRLPMANVGAIFLPVSLFWFGWTVDKGLPWPVPLAATLFFGGAQVSIFNTVQTYYIDAYESNAASALAAGAFLRSILGGVVPLFVSAMFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXT7</accession>
    <name>F9WXT7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_98339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856108.1">
        <property type="nucleotide sequence ID" value="XM_003856060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXT7"/>
    <dbReference type="FunCoup" id="F9WXT7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WXT7"/>
    <dbReference type="GeneID" id="13394361"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98339"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.597"/>
    <dbReference type="eggNOG" id="ENOG502QQS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026794_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXT7"/>
    <dbReference type="OMA" id="KRAHFCF"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="42543" checksum="4E210C1C76710770" modified="2011-10-19" version="1">MSVDINWETLTGGPDGEALAETIRDFVHERFQSLPLPKLIRSITVHGFEFGKIPPAIVLKDICDPLPDFYDTEEDDATTDDDSRHRGETKEPQQQGIRHSTTRDLRGAAGSRRQSELDILDRSATTTLTRGTTPGVLGTTSNLGYFHLPMSAGLSGTQTPLAAVAGAHFPTVSHPPHPQHHHSQSFSSVSPNSTATPVSSHGHGYFDNAAESATVEDDDIPTQPLNEDQPDRSSEDMQVVFHATYAGDVRLSLTADVFLDYPMPSFVGIPLKLRITGFTFNGIGILAYIKKRAHLSFLNPEDAEALVGGEPSMQTSDEKQETSPNGDPTPSKVGALLEDIKIESEMGETESGRQVLKNVGKIEKFILEQVQRIFEDEFVYPSFWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYA4</accession>
    <name>F9WYA4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_35107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857146.1">
        <property type="nucleotide sequence ID" value="XM_003857098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYA4"/>
    <dbReference type="GeneID" id="13399009"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35107"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1457"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="InParanoid" id="F9WYA4"/>
    <dbReference type="OMA" id="IGSHILM"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001024">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37531" checksum="72CA103A58014139" modified="2011-10-19" version="1">MGAELSDDLLSIPVKVLAHCVKEQQVRFAFLQSGEVIILATGSIVNFGLNQLDGEGALVNGWRYMYLVQGLIAMLLGIITYFWIVPFPENAHEAVRFLTADEQKLAVSRIQKDRKDVQAEPFTWREIFHHAKDVKVYGFACMFFLLNLVSTSLSYFLPIILQSGMGFSENKSILLSAPPYYYAVLPVIISSVVGDNFNLRGPIIVFNCICLIIGFCMLGFTDQVTVRYIGTYLATGAYVSNWAAITTYQANNITGQWKRAFTAAAVTAMNGAGGIAGSYIVRQEEAPRYMTAVWISIGSHILIIAFVGVFSLYFHAMNKRQRAGKALLEGTVGFRYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYH3</accession>
    <name>F9WYH3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_102841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857032.1">
        <property type="nucleotide sequence ID" value="XM_003856984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYH3"/>
    <dbReference type="STRING" id="336722.F9WYH3"/>
    <dbReference type="GeneID" id="13398055"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102841"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1707"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="F9WYH3"/>
    <dbReference type="OMA" id="QKISGYY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="37070" checksum="C826096A07975636" modified="2011-10-19" version="1">MGDIPKKYKAVIYDEPGKVSTKVVELDMPEPGPGEVLVNLTHSGVCHSDFGVMTNAWRGLPAPTSPGQVGGHEGIGKIVKMGPGTDGSAVKVGQRVGIKWISGICDTCPACLAGHDGVCFNQKVSGYYTPGTFQQYTLAPANYVTPIPDGLDSAMAAPMLCAGVTVYSALRKSTAQAGDWVAIMGAGGGLGHLACQIASKGLGLRVIGIDHGSKKELATECGAEVFIDHTQGNVEEEVKKATGGLGAQSVLVLTAANGAYASSMNLLRFGGTLVCVGIPEGDFVAIAGAFPGLLVAKAQKIVGVAVGNRREAIETLDFAARGIVKTHFRTAKMEELTGIFEQMERGEVVGRVVLDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ23</accession>
    <name>F9WZ23_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_89139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857512.1">
        <property type="nucleotide sequence ID" value="XM_003857464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ23"/>
    <dbReference type="STRING" id="336722.F9WZ23"/>
    <dbReference type="GeneID" id="13403083"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89139"/>
    <dbReference type="eggNOG" id="ENOG502SKVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625860_0_0_1"/>
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    <dbReference type="OMA" id="PARAYGM"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="438" mass="48428" checksum="0BBE76EF2E6CF53E" modified="2011-10-19" version="1">MDSVLRNQTTEVESSPIMRAMPQEQLAVIVVGAIFTLIGLFANLCRTITLLQRRRGPWWDDFAAFAAFTFFIGFAAAAFVAVRWGVGLPTSDIPTGWASRAIQAGYAMEMLYFFSIFCVKMSVLLLYLRLARKLRDIIYQLCIGLSILLAIFFFTTIIVAAAQCVPTHKYWSPDAEGHCIDVTAFFYATNIFTIVTDLAMLALSIPLILKAKRQRSQNVGIIVAILTGALSVTASCARLHSIVIYDFSREPLRDAAPIYIWSFIEISAGMCCASMAVIVPLFTAYSVRISAIISPIGPSNQMVSFANYAEAWPYGRNGPMGKYVPAAIQGQSRRTTQDLTDLSPPHTINGRPIRISKPLPELPKACFHEEGLTALPQSPAKAYHRDGTLTALPQRSNQPMLHAIAMHNAGKMDPAAPVYGSRVREREVQEWENTGLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ47</accession>
    <name>F9WZ47_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_89160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ47"/>
    <dbReference type="STRING" id="336722.F9WZ47"/>
    <dbReference type="GeneID" id="13394483"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89160"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046009_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZ47"/>
    <dbReference type="OMA" id="HHMLPGR"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="PHI-base" id="PHI:6548"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="393" mass="42299" checksum="77DBC3460F86065B" modified="2011-10-19" version="1">MVGERRGTRTPDLERRGEPRMTEIPGASTGRGHVWIVAAGLNAHRQLLDSQPDDLTSFQKIHEGNDSDVNVWFASWSNTIFATDAGLRGIGHQKVLDNSKVLLVSPVGDHDGVLLALDSDGQLYRAEEQTEQGIVAMVCRSTDSSPSIGRLAYAENGRVAITIKQAPNGNLCHVEEFKDLETFLRWFQDPSGDGNYPERHFMLPGRPKQLKAGTGIFVLLMESGQVYTWGDSRYRSLGRSVTGDGSKSADEPAVLEALDGLHIKKVDCCGWMSAALSDDGALYLWGITSPSDDVKIGALAAGEDEEVALVELPGDGSEPLDVVDVALGVEHIAVLAESGRLFVTGDKSCGQLGLGDKQKSAECWQEVTLPSIEIEAVFCGPRSTLALVRSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZE7</accession>
    <name>F9WZE7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_107360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857240.1">
        <property type="nucleotide sequence ID" value="XM_003857192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZE7"/>
    <dbReference type="FunCoup" id="F9WZE7">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZE7"/>
    <dbReference type="GeneID" id="13395058"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107360"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZE7"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
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        <property type="entry name" value="speE"/>
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    </dbReference>
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        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
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        <property type="entry name" value="Spermine_synt_N"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
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        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="291" mass="33020" checksum="23471FD99EAE64B3" modified="2011-10-19" version="1">MAEITHPTIKDGWFREQSDMWPGQAMTLKVNQVVHHEKSQYQDVLIFESSDHGMVLVLDNVIQCTERDEFAYQEMITHLAMFAHPNPKKVLVIGGGDGGVLREVVKHESVEEATLCDIDEAVIRLSKKYLPGMSVGFQHPNVKVHVGDGFKFLEDYKDTFDVIITDSSDPEGPAESLFQKPYFELLHGALREGGIISTQAENPWLHLNMITELKKSVKTVFPVAEYGWTTIPTYPSGQIGFMVCSKDGSRNVKKPQRTLSDEEEDKLFKYYSSKIHEAAFVLPKFVEQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZG7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855855.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZG7"/>
    <dbReference type="STRING" id="336722.F9WZG7"/>
    <dbReference type="GeneID" id="13403777"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.59"/>
    <dbReference type="eggNOG" id="ENOG502QT8T">
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    </dbReference>
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    <dbReference type="OrthoDB" id="192702at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="424" mass="45670" checksum="7058EA08408B1918" modified="2011-10-19" version="1">MPFPNPSSSPSATIHIISKANLTVHKTLTYTPSPSPPLPLSSIRAQISLLAITGNTYTYARGGATLHWWDAYPVPSGSHLSPDKWGIVPTWGFADVVDSTIAGIPVGSRLFGFWPTARMAVDLKLEEGSSEGHWLEVSDERRSLMAMYNRYRLVVPDGLRNASEREALMAGCAVWQAGWLLSRFIFAAGGSGEIPIHPLGGEISWSRDDADLSRAVVVSLAASSKTGRAFGWAMRKRDVQTDGPLALLEATSNVEAIGGRGGGSSVPSKVVMYSDLCDAHTLGWMVGHSPRKIVIVDFGATAEVVASLVKTIRRTMMGMSVMVVGVGGQTKIMSESDVQRIQVVNQDVGRVQMNTSGVIDKAIGLHGAEKFFAKMDAAWEQIQRDSVYDNQKIEWSEGVGGIEHAWAKLVADQVSGTSFAAVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZI0</accession>
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        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_31554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857730.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9WZI0"/>
    <dbReference type="GeneID" id="13403349"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31554"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
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    <dbReference type="OMA" id="DTYGWNR"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="456"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="682" mass="76280" checksum="1E9E9E20D6BAD6E7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZV6</accession>
    <name>F9WZV6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856063.1">
        <property type="nucleotide sequence ID" value="XM_003856015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZV6"/>
    <dbReference type="GeneID" id="13394316"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89015"/>
    <dbReference type="HOGENOM" id="CLU_1826826_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZV6"/>
    <dbReference type="OMA" id="QRFICLY"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="141" mass="16246" checksum="A194DC8F8B9A5BEC" modified="2011-10-19" version="1">MSYYDPPSGYYNQSPNQRSSYATSQQQPYAPYASSYQGYPILQRRPQQQPPPQQYYSSPSTSPGSIYSQPQSPPCQPVQSTPGYHCLYPNCTHTTSRKTDLERHCDRTGRYGFSTKDKMVDHMRQVHEADIPKKRRSSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X033</accession>
    <name>F9X033_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_102441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856299.1">
        <property type="nucleotide sequence ID" value="XM_003856251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X033"/>
    <dbReference type="GeneID" id="13402935"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102441"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.981"/>
    <dbReference type="eggNOG" id="ENOG502RNKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041826_0_0_1"/>
    <dbReference type="InParanoid" id="F9X033"/>
    <dbReference type="OMA" id="CSMMFPK"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="39700" checksum="4064942EEDFF54B1" modified="2011-10-19" version="1">MPVQLLPASAQAFAPRSAPEIVLNSKVESWLTQTLKRINRVKRPLNSVPQHHRCLTETLGGTLAIWTLASLMLPKAPDADLRKDDNPLTEALFNHQLIHIEAYVVHVDMVSQHEVAFKLTTDTIELLIEYHKDIYSVDASASTWSWPEKESHVKKMQDEFVQAANKFVFRTHVRALEGLEEDGAGELLEGRSEDVKNAIMNMFVPLLPPPPRIVDVIHPAPILPTSSMAGHWWTPSPQQQLAPAHPAPVDTWRVLPSTPSPTATTCSDSRSNSFWQDMQYGQQVQLPSPTPSFSQPIAYTTAPAQFYSSPQSIAPMPALIMPHQMPHHCGVDMVMGGYSDFGWSQSSWTPQYATTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1H7</accession>
    <name>F9X1H7_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_107738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP91884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1H7"/>
    <dbReference type="GeneID" id="13398543"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107738"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="F9X1H7"/>
    <dbReference type="OMA" id="NMYFGYT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395469" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="399" mass="42781" checksum="63B7BA43B2828B7C" modified="2011-10-19" version="1">MAGKYSFLCLAATLVQVVLASPAGSIVVPLKRDEVLLDYLAKFSVGTPPQEEYLKIDTGSSAMSFYSPRSDFCNADDRPCDVYGTFDNVSSSTSTYTGPGFSDQLISYGYGDYLEDTVSVGGVSTPHVDFGYITTVGYPSRKQRPAASIVGFCLSCYPGPNCDGPGPYLLPQLKKASAIDRISLSVYLGPDERDVNNAEIILGGAYDKAKLGGELFTVNMVDPHNSHLTNQNTNNVNVSSIEAVSGDKTIKIDSPEKEGTVYLLDTGAPYWSIPTEMFNLVSTAFGGLSATTSYYTYIVDCKYQFPANSNGCINVEFTAGGTISVPFHTLVTDFGNGTCVTAVQPGGGNLLGDPFLRSVYAIFDQEDFTVSLAQVKHTQERDIVAIPKGGFKPAGLERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Y4</accession>
    <name>F9X1Y4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PKS9</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_9788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855768.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1Y4"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_9788"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="InParanoid" id="F9X1Y4"/>
    <dbReference type="OMA" id="CASDYND"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="281"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1537"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1329"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1615"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1484"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1514"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1633"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1665"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="2396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="2396" mass="261870" checksum="6BD3A643D3B72F7A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X210</accession>
    <name>F9X210_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GliK</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_35967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
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        <property type="protein sequence ID" value="EGP89693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854669.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X210"/>
    <dbReference type="GeneID" id="13403746"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35967"/>
    <dbReference type="eggNOG" id="ENOG502SBD2">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030506_0_0_1"/>
    <dbReference type="InParanoid" id="F9X210"/>
    <dbReference type="OMA" id="HDTIWAG"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="29317" checksum="F594F0B49CB99602" modified="2011-10-19" version="1">MDLFHDIWYFAYGSNMKTSVMTSRGLGILEHIPVRAPSYMLTFDIYGIPYSEPSMASICQYRRGGGDGNGGQDAAYTCPPDVHGVAYRLNAEGYARLIASEGGGVGYRELQIQGVPVGSESTSIQMWTLVALHPKRPNAAPSLRYLRLIQEGAAEHALPQPYQEYLRTIPYYTASDSWISRLGARIFLSVARKQVRVLAYAVRSSVDVSGRSRKVWRTVAYVVFHAMWCVHDWAFKPIFGSGSGLEVDYGSSTLLVWRNGEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X230</accession>
    <name>F9X230_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_35783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855715.1">
        <property type="nucleotide sequence ID" value="XM_003855667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X230"/>
    <dbReference type="STRING" id="336722.F9X230"/>
    <dbReference type="GeneID" id="13403655"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35783"/>
    <dbReference type="eggNOG" id="ENOG502S02V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066046_0_0_1"/>
    <dbReference type="InParanoid" id="F9X230"/>
    <dbReference type="OMA" id="PRCTEYV"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="277" mass="31584" checksum="B67010FD28EABDFE" modified="2011-10-19" version="1">MALSEKIWQRSVNLRTEIPRRHPQYPAIPFFKANFAHSPYTLWDLFPATWTCPHDMQRIGNLGDGGKWVCGLSIYETEGLVVYSFGIAADSSFEAELLDRVPSIRIWGYDDSATYWGPQISGDLFNHRVFFAPFRLASEDSHSGKASAWTISSLMKRNGHDYVDILKIDIEGSEYGVLDALIESIQSIRTASGRGVLPIGQILIELHAGKEVEEATGKSLDFLRFQEWWERLESMDMRPVWMEVNLLGITSRENNTDPDCAEYVFVNVLDEQSVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X238</accession>
    <name>F9X238_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_84472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855712.1">
        <property type="nucleotide sequence ID" value="XM_003855664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X238"/>
    <dbReference type="FunCoup" id="F9X238">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X238"/>
    <dbReference type="GeneID" id="13395998"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84472"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.263"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="InParanoid" id="F9X238"/>
    <dbReference type="OMA" id="IGGHAMS"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="234" mass="24803" checksum="868F337ECCB1CF9C" modified="2011-10-19" version="1">MFTGIVEVIGNVSSLISHDESSSGGSGTSLTISSASEILDDCHLGDSISINGTCLTVTEFDKDSFKVGVSPETLRRTNLGDLKVGSGVNLERAVSSSTRMGGHFVQGHVDTVATIADKREDGNAVTYRLSPRDKSVLRYVVEKGYVTLDGASLTVTAVEDGEEGWWEVMLIAYTQGKVVMGGKGVGEGVNVEVDMVGKYVEKSVAAYFEGAGEGGGKVLEKMVNRLVEERLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X283</accession>
    <name>F9X283_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_68240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854905.1">
        <property type="nucleotide sequence ID" value="XM_003854857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X283"/>
    <dbReference type="STRING" id="336722.F9X283"/>
    <dbReference type="GeneID" id="13403537"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68240"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="F9X283"/>
    <dbReference type="OMA" id="EMMKMWT"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="575" mass="62013" checksum="B161AB161D4CC5BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2G1</accession>
    <name>F9X2G1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_36419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855020.1">
        <property type="nucleotide sequence ID" value="XM_003854972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2G1"/>
    <dbReference type="FunCoup" id="F9X2G1">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2G1"/>
    <dbReference type="GeneID" id="13403412"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36419"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2G1"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="426" mass="47124" checksum="DAF9E253CB7DEB1C" modified="2011-10-19" version="1">MPAGSPAVQNGNEPQGNDDPGDMLRPGVEEEDNSGTPPIAEPEADMEMREADDAPDGDLESDLEELDEEQFDDFDPSALNIPDKPLMVDETNKKRDRPSKRSKKSADDEDDFEGGVEMDGKRARNTGEGRPGKAAKRARTPEDEENLSPEERRRRALDRKMDEALKSHTRVSRRKQGQDMEERADQELGQMRERIGKACEADAKAREAGGMATQKLKILPDLVELLNRNTIQAQLVDPDVNILEGVRWMLEPADQDAALPNYKIQRELFNILSRLNIGKEALKASQIGKVVLFYTKSTQPQPAIKQMAQRLVGEWMRIILNKTKDHRNVNIETREYDPVLAEQSQRAAGTQIDRSAIAAEKRRKILAAPGPTNRARVEGGLGTYTIAPVSNLSNAQGVSSRTLGSSGADAFRKIAARSQGGKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2N9</accession>
    <name>F9X2N9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgPP2CL-1, protein phosphatase 2C-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MgPP2CL-1</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_68012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Martins N."/>
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                <person name="Rudd J.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="613" mass="65073" checksum="DA8BB4BD9C642D8D" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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        </source>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="de Vries R.P."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
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    </reference>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EGP90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="214" mass="24251" checksum="64FE200731445671" modified="2011-10-19" version="1">MASNSDQVEQSKSRKRKRNTEIQSSGQEIIATASEVNQEDMEKFSQVVIALQARLVAFEKEHAALVKIYKLSISDRNKFISHYKTVNHIDQEDDDDQQHESADARNTHVKYLEKKEAKLKTRIEDYNKLLNMHFTCVRKRVKIESMSVEPSQIEVAARALAEMSDMAQLSGGLANLLEACNEKENVTEAELKSKAQPGAVVLKMEQQLESDQVS</sequence>
</entry>
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    <accession>F9X3D3</accession>
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        <recommendedName>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855761.1">
        <property type="nucleotide sequence ID" value="XM_003855713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D3"/>
    <dbReference type="FunCoup" id="F9X3D3">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3D3"/>
    <dbReference type="GeneID" id="13403701"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67807"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="InParanoid" id="F9X3D3"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="401"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="687" mass="74111" checksum="4CB9357C9A5CF007" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3H3</accession>
    <name>F9X3H3_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854853.1">
        <property type="nucleotide sequence ID" value="XM_003854805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3H3"/>
    <dbReference type="GeneID" id="13399342"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90590"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.361"/>
    <dbReference type="HOGENOM" id="CLU_1134324_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3H3"/>
    <dbReference type="OrthoDB" id="3682925at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="245" mass="28632" checksum="2186472927A8E748" modified="2011-10-19" version="1">MAPTDKVTLFSLSKDIRLSIFEHLLVPGSFELGSPDECGRPRWTHIIRPEYAETPSDERHLCHSRIARGWHDEKAQLIRLFGYNAKYLQYQLRSGRSRMPGIGPHDPRLHDLNDPMLSERGLRTVRRYATCAYGACDWRSSTTLTRDACAKFFAPLLICKALYLELRTLVFSDNVFSFRAPKDLLRFISRLSSWQRDELRRVQILHSNIVILFKSISNAREDMERRERLMGRTSLQRYSTAQTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4N2</accession>
    <name>F9X4N2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_103393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855099.1">
        <property type="nucleotide sequence ID" value="XM_003855051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4N2"/>
    <dbReference type="STRING" id="336722.F9X4N2"/>
    <dbReference type="GeneID" id="13400041"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103393"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.918"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_0_1"/>
    <dbReference type="InParanoid" id="F9X4N2"/>
    <dbReference type="OMA" id="NHNVHRS"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395331" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="122"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="29567" checksum="1E231476513E51B0" modified="2011-10-19" version="1">MRSVFAVAALAAGALAVPYAEKRGLEAYVEDVVYETQLVTVTAYHNGNGPAPAATSSAAAPPAPHYGHKNPPPPPPAPAATSAAPAPPPSYPAPPSYQPPAAPASSAPASSGNQGSGETPTDYKSKVVHFHNLVRDNHGCSAVEWDEDLYNCAKEIASSCVYAHNVDVQGGGYGQNIAAGVDEDHIGSVLIDMFYNNEMPHYTWYGGEPDMGSFDVWGHGTQMVWKSTTHVACATQHCPNGLANTGAGVSAWFTVCNYKGPGNFAGQFAENVLPPKGPPSISGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X508</accession>
    <name>F9X508_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_91290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855225.1">
        <property type="nucleotide sequence ID" value="XM_003855177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X508"/>
    <dbReference type="GeneID" id="13400469"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91290"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1250"/>
    <dbReference type="eggNOG" id="ENOG502STG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2279701_0_0_1"/>
    <dbReference type="InParanoid" id="F9X508"/>
    <dbReference type="OrthoDB" id="2555528at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11459" checksum="693899095AB399B3" modified="2011-10-19" version="1">MVTPFTTFSPREHRDTSDTDYSILANFGAGCWLVLPKLQLRVHLQPYDLVIFQTNSLTHATAAVDGDCEADQRWSLSYYQRKAVRNDCLGASPTYAANGQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5D8</accession>
    <name>F9X5D8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF336-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_69221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854667.1">
        <property type="nucleotide sequence ID" value="XM_003854619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5D8"/>
    <dbReference type="GeneID" id="13395853"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69221"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.26"/>
    <dbReference type="eggNOG" id="ENOG502SMVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_0_1"/>
    <dbReference type="InParanoid" id="F9X5D8"/>
    <dbReference type="OMA" id="VAHVRMD"/>
    <dbReference type="OrthoDB" id="2276076at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16036" checksum="49DD6435693AC6F5" modified="2011-10-19" version="1">MPVTRSVPMLSLEAAVIASNAAQEKAKQLGIDFNIALVDSSLHLLHFTRMPTAKLTSIDIAINKAFTAAGHRLPTSAYSTGNGAKNFQPGGVAYSIHNSNGGRFSLIGGGIPIEVEGTVVGAIGVSTGTPAQDAEVAQAGVDAVKAWEGRRTGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5G7</accession>
    <name>F9X5G7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_38718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853636.1">
        <property type="nucleotide sequence ID" value="XM_003853588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5G7"/>
    <dbReference type="GeneID" id="13395838"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38718"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="F9X5G7"/>
    <dbReference type="OMA" id="PVAAFIW"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="501" mass="54403" checksum="ABF18B59B5F660EB" modified="2011-10-19" version="1">MTVYANDTPSNKSNPEKNAASVDHLNETSVPYIVPDKPITPELLAAVPGGVKASELFEDAAPILALNLPDWRATEKKLAQAQLAEPSMGESLNFESGGEDYNTAVSLLTVGYMIMQLPSNMLLTRVRPGIYLPATAIIWSAVSACTAAVPDVRTLWGVRFILGMTEAPLFPGAVYLLSCWYTRKEIALRIAILYSGLVLAQAMSGILAAGIFNGMEGVAGIMGWQWLFIIEALMSTVCGIAALFLLPDYPESKTGSQKWTMDEDCRRLAVARVEADRVTGSTGSGKVWDGIKLVMTDPKMYLFMFLNLTMTASYGFNFFFPILVQGLGIGNRIVSLLLTSPPYFLGAAVSFAIARDSDRIRERGYHIVGSLTASMIGFVITVATPNTAARYAASFLYAPGSFSANALVYSWAVSSAGQTPEKRAAAGAIVNIVGHVGNIISPYFFRDDTRPEYPLAWILMLVFGALAMGLALSTKFFLKFENRRIKRRTDDSGAVYNPYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5W5</accession>
    <name>F9X5W5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_38162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854038.1">
        <property type="nucleotide sequence ID" value="XM_003853990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5W5"/>
    <dbReference type="FunCoup" id="F9X5W5">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5W5"/>
    <dbReference type="GeneID" id="13404376"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38162"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="F9X5W5"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="537"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="665" mass="74908" checksum="7118977E0E1BA7A6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X625</accession>
    <name>F9X625_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_108426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854629.1">
        <property type="nucleotide sequence ID" value="XM_003854581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X625"/>
    <dbReference type="FunCoup" id="F9X625">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X625"/>
    <dbReference type="GeneID" id="13395815"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108426"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.106"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_0_0_1"/>
    <dbReference type="InParanoid" id="F9X625"/>
    <dbReference type="OMA" id="CVHMNDS"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="72"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="462" mass="50370" checksum="CE86C856A379D8E8" modified="2011-10-19" version="1">MAEKIEKTIYVGSFLHCASLAELDYCESGMIGVDEHGKIAFITRDVDGQQVPIPPGWESARTIILTGEGFFFPGFIDTHIHASQYPNAGVFGKSTLLDWLNTYTFPLESSFTDLKTAARIYNRVVARTLSHGTTTATYYATIHVPATNLLADICLSRGQRAFIGRVCMDSALSPDFYRDASPEESLFSTEACISHIRSIDPDFSLISPIITPRFAPSCSLESMTALGELHAASGIPVQTHISENLDECALVARMFPDHASYADVYDSCGLLSSRTILAHAIHLSPAERNLIRERDAKISHCPASNTALTSGTAKVRDLLNEGLTIGLGTDVSGGCTPSLLNQAREAIYVSRHVAMSPGQDAAKLSVAEALYLATRGGAKVVGLEDRVGGFEVGMDWDAQMVRFARVGEQVELGKESEGLVEIFGNESWEDKVAKWLYTGDDRNTVAVWVRGRLVHWREGWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6B3</accession>
    <name>F9X6B3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_69971</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853888.1">
        <property type="nucleotide sequence ID" value="XM_003853840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6B3"/>
    <dbReference type="FunCoup" id="F9X6B3">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6B3"/>
    <dbReference type="GeneID" id="13404227"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69971"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.631"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="InParanoid" id="F9X6B3"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="200"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="462" mass="50681" checksum="A3D8564B74EDF3B3" modified="2011-10-19" version="1">MSVLLTSRQAEELHKSLIAYLLSTGHADSAQVLRDNLNLPESDFDAATAKKYEGLLEKKWTSVVRLQKKIMDLEARSQQLQQELDSATPSSLAARKNHDPQTWLPRAPARHTLMSHRQPITCVAFHPLFSSLASGSEDCTIKIWDYELGELERTLKSHTKAVLDVDFGGPRGNTLLASCSSDLTIKLWDPAEEYKNIRTLPGHDHSVSSVRFIPSGAAGAPLSGNLLASASRDKTIRIWDVTTGYCLRTLRGHNDWVRSLSPTFDGRWLLSTSSDQTSRMWDLSQPDSNAQKQTFMGHEHVVECCAFAPPAAYVHLASLAGVKKPPASTSSAEYLATGGRDKLIKLHTANGVCIKTLTGHDNWIRSLVFHPGGKYLLSCSDDKTIRCWDLAQEGKCVRVVEAADHFVSCLRWAPSLYKEAGAAGDTNGGLTNGSGKEEAQKEQIRCLIACGSVDLNVRVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6K8</accession>
    <name>F9X6K8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_39514</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854615.1">
        <property type="nucleotide sequence ID" value="XM_003854567.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9X6K8">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6K8"/>
    <dbReference type="GeneID" id="13395802"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39514"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="InParanoid" id="F9X6K8"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="898"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="1587"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="1892"/>
            <end position="1928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP89591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1997" mass="223772" checksum="9BB210A9CC131EFB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6Q9</accession>
    <name>F9X6Q9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_103663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="199"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="28341" checksum="1167A5F8BC9D44D0" modified="2011-10-19" version="1">MHVKDRTFVITGGASGLGLATAEDLHQHGGYIAILDMNPENGEKVVKSIGGDRAKFFEVDVTETESLEAAVKSVVEWTKQTSKPVGGVIPAAGVGRPGKLLDRNLNPIKMEALDWVIDINLRGVLNTIRLVLPHMARNEPIGEDNERGVIVMVSSSSAFEGQVGQLSYAATKGAIRSMTLVLARDLAPNGIRAMSIAPSLFKTAMSDQLSPKVLQALVSATEYPKRLGNAKEFAMMVRQCIENPYLNGECVRLDGAVRMPAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21049"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="InParanoid" id="F9X728"/>
    <dbReference type="OMA" id="WHSPQAW"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
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            <end position="614"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="repeat" description="TPR" evidence="3">
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            <end position="750"/>
        </location>
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            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <position position="770"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89177.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="770" mass="85299" checksum="D6D00DF7B1F8E97D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7B1</accession>
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        <alternativeName>
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            <shortName evidence="4">eIF3 p93</shortName>
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        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
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        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
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        <property type="nucleotide sequence ID" value="XM_003854277.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF3C"/>
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        <property type="entry name" value="EIF3C_N_dom"/>
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        <property type="entry name" value="PCI_dom"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
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        <location>
            <begin position="604"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="807"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="870" mass="97709" checksum="F2E0E858C02A9DF7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7X6</accession>
    <name>F9X7X6_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="336722.F9X7X6"/>
    <dbReference type="GeneID" id="13404316"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38046"/>
    <dbReference type="eggNOG" id="KOG0118">
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    <dbReference type="OMA" id="MIFRQKP"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="306"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="499" mass="52841" checksum="B2DBDD245C1D999C" modified="2011-10-19" version="1">MSFGFDARPAPAVVIRRLPRNTSAETLRSMLIFAGDLIDTEFIRSPYPEDQGFATAVARFQSSTGAFEAQQKLHGKPNTAKDATMIVETHGGSATSSFERRNTVDGASATSRTPTSSSSSVGSLGGPPGRSRFGSTFHPSEKVSPPLSMSSSGGTGDFPIPESSAHFQNLFSPQSPLTNGHHRISGKSMINDDSVDDETGELLKDPVAYAKSGQQPAMRRSTNPQIPLGRFASMSLSSPNGGHNTGHVSGNGYGSPRGTSALHSPVPPMSPTDGPHAGPNGQYMAANYPRPHYPPVNPADQNPPCNTLYVGNLPIDTSEDELKSLFSKQRGYKRLCFRTKQNGPMCFVEFEDTSFATKTLHELYGHPLHNSVKGGIRLSFSKNPLGVRSGQTNGISPHAAMSPQAMAPGLGGMMNGYSSVSGPPPGLGSGMMNGGSYRGPPPITTDSMFSNPFGMASPDFAAQLSPRNTFSGGIPPTLGAGMYGRDSRNHSYADYMPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X842</accession>
    <name>F9X842_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_108936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
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                <person name="Dehal P."/>
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                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 115943 / IPO323</strain>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="496" mass="55391" checksum="C869FC2A9B62FDD8" modified="2011-10-19" version="1">MADIDLNSARQTRLPAITFKEPRAHDFPIVKFTCPHPHDTCMAIKGWLLNSVKEGALERRVIRMERLHLSDLPTETEGSLILLEYAAQADELRISILALVMPRDPNIRWFYSAKPIDDLLTTLAELEYITTPLVREPTPDHRIWGKVKKREPELRIPLPRRMMNGEEQEGEPDHHCRLFVFVRQCFLNSIAVPHHPDYIEALKFTDYSPEIMDPDTALTRIQADEISAHSKDGKDLSDDRYLLELHPAEREIASLVHLNCAEYLLMKRKFFFEFYIEMMHTNKHVEGGKQRVKSDRAHQRWLEDTEPWKLPSARARRCVAGWKVLGLLDERVLFAWIRSGGKSASSKHSAEMTSSGVIDWVGIGSGSEVVVVGSGSGSGVGVGVGVVVSVATQLAQLEVSTHACWPPEPAHWENVVVDAQILPEEDPTPVDNAGRLVHTGREGRVENVVSSEVDGKELVVGGSELMLGGTSIRSDSVSSDMSVSGRTVAPCIQRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_370961_0_0_1"/>
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    <dbReference type="OMA" id="FAYARIK"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <dbReference type="GO" id="GO:0000781">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
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        <location>
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            <end position="177"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="248"/>
        </location>
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            <end position="352"/>
        </location>
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            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="729"/>
        </location>
    </feature>
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            <end position="211"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="458"/>
        </location>
    </feature>
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            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="514"/>
        </location>
    </feature>
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        <location>
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            <end position="582"/>
        </location>
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        <location>
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            <end position="705"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88554.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="PANTHER" id="PTHR46093">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="516"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="698" mass="77492" checksum="47DFCE5549455599" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8F0</accession>
    <name>F9X8F0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_71174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8F0"/>
    <dbReference type="GeneID" id="13397329"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71174"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="InParanoid" id="F9X8F0"/>
    <dbReference type="OMA" id="FHKTTVW"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="561" mass="64004" checksum="2063E950360B0350" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8J0</accession>
    <name>F9X8J0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8J0"/>
    <dbReference type="GeneID" id="13400200"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92623"/>
    <dbReference type="HOGENOM" id="CLU_767709_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8J0"/>
    <dbReference type="OrthoDB" id="3649949at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395405" description="Ca2+-modulated nonselective cation channel polycystin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39009" checksum="C9202CF42B8A4736" modified="2011-10-19" version="1">MAGFHAFLMLTFASLIHATPYNVLLARQEQSEVCPTGLAGYATDGAQCIETGGEDFVSSLCGAFPPLVTETFSTSSHLCCSDGLYTSTIHQDKILTPPSSFTAVALAAIAENYKRQEPSGTPDCLTAYQRQRGEEGIRDACSCLVPGQASSTTSITRTNVITSRRTQTQLGTTTIRGTTFYTNVTTATATVLSTETRTITVPRTIAATSTRTITRTISTSLPSPTPARFRIYYNATSPSSTSTTRIYGARTTAPADPSVYEIAFTPRTLPDEFALNSASQLVDLTFFRTITTRNRQDPYPFVFLNAAADAQGEDGQGLIVPMCSLKDMAIVNEAESDLGQPAPDLWNRSYRQDVSVGLYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X965</accession>
    <name>F9X965_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_40054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853227.1">
        <property type="nucleotide sequence ID" value="XM_003853179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X965"/>
    <dbReference type="STRING" id="336722.F9X965"/>
    <dbReference type="GeneID" id="13399744"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40054"/>
    <dbReference type="eggNOG" id="ENOG502SQ2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026305_3_1_1"/>
    <dbReference type="InParanoid" id="F9X965"/>
    <dbReference type="OMA" id="RVYWESG"/>
    <dbReference type="OrthoDB" id="3648680at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="267"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="446" mass="49752" checksum="A1DB523DA9A82A8F" modified="2011-10-19" version="1" fragment="single">RAASSCPARMSGVEVIGLVLGAIPLIISGLEHYKTCVKTIKSIKHTAVELGTVARNLRTEGLMFRNTLQILLSQCLDHETQKQLLDASADGWDQGNVRDALQQRLQTSYELYMEHVHRVRSTLSEFMERLHLGPDGKPPCDTTAASFRSAYKRLGFAIKKSGYLDLIQEIHDVNVMLERLTGQTRELEAGRKLRATDIKHIEAPKPVLSVSSSTAAFDATISHATGSSKITVRSHSVRFQSPSRIHIAPTLPPILPPENRKQNLTGADARRLALSLATGMLQLHSTPWLQSSWGKSDIMLISKQDKILSQHAFISQDSTGARKTLPASPATGALAMIIKNRTLFSLGLMLIELCMGKSMEDLHRADERNPDGTISEFSDLLTAERLLNKQTISESFGKRWSDVVRRCIRCEVDETESSLEDAGFRKAVYNKILMELEEEHRQFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Q4</accession>
    <name>F9X9Q4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">General negative regulator of transcription subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MOT2</name>
        <name evidence="18" type="ORF">MYCGRDRAFT_109208</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003853024.1"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="F9X9Q4"/>
    <dbReference type="OMA" id="CLITPRG"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0016567">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
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    </dbReference>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
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    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1473" mass="158201" checksum="677F39D424B2A689" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9X8</accession>
    <name>F9X9X8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_85500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853596.1">
        <property type="nucleotide sequence ID" value="XM_003853548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9X8"/>
    <dbReference type="STRING" id="336722.F9X9X8"/>
    <dbReference type="GeneID" id="13400868"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85500"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9X8"/>
    <dbReference type="OMA" id="LVNWTCD"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="252" mass="28697" checksum="F63541D86140FBF4" modified="2011-10-19" version="1">MHVDSNSKECILVYPYFRDTLLALLQNDPAFPPDERVRIMRRVAEAVQELHAQDWIHADIKPDNVLVDWESDSEGNKTVTNVALGDFDIACKLKEGETRLTPHAVGNAMWRSPEAQTGISTRASDVYSLGLVYIYTLGAGELLVLRNYQDLVKAGITPEQEIITKHFCYFGPVPESLYQQIRDENWRTALRSASEMAEAEVKERPILRFRLWGQELGDSAMELLSGMTNLDPKARLTMDQVLALEYWRELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAM2</accession>
    <name>F9XAM2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_109345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852047.1">
        <property type="nucleotide sequence ID" value="XM_003851999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAM2"/>
    <dbReference type="GeneID" id="13393823"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109345"/>
    <dbReference type="eggNOG" id="ENOG502QSFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="InParanoid" id="F9XAM2"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="57"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="493" mass="53601" checksum="E536D68654E26368" modified="2011-10-19" version="1">MASTEYGITRDQGYNMPSDSDSNKKSSDPEKELAEKVSSNDLTQQTTLHEGESKFKKLGWKRLTICLIVEAIALGSLSVPSAFATVGMVPGVILCIGLGLVAIYTSYVVGQVKLRHPHVADYADAVQLIWGKFGYHLTSAMFVLFLVLLVGSHVLTGTIAWIRIVDDPSTCALVWGVLSAIILFAVALPPTFHEFAILGYIDFVSIILAIMITIIATGIEAHNGPGGLSGVDWSAWPKEGTTFASAFLSVTNIIFAYSFAVCQFSFMSEMHRPQDYVKSIWALGIIEIFIYTVTGALIYAFVGSAVASPALLSASHIVTRVAFGVALPVIFISGSINGTVVGKYIMNRAFPNSPLRFINSVKGWAVWMSLIAFLTLIAFVIAEAIPFFNALLGLISALFISGFTFYFPALFWFQLIKEGKWNASRKNIILSITNAAVLIIGALVLVCGTYASVEDILTQFNKGEDEEEEEEEKMLKGPESHEDGNEQGKKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAN8</accession>
    <name>F9XAN8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92990"/>
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    <dbReference type="eggNOG" id="ENOG502TJ8E">
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    </dbReference>
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    <dbReference type="OMA" id="VVQDYAN"/>
    <dbReference type="OrthoDB" id="3642362at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395575" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="222" mass="23876" checksum="22B05653191D3B50" modified="2011-10-19" version="1">MVAFKLLTLVGLAATAVAQVSFGAPENSAEILSLLQDANQYTVSSGQNAARYRAGNPSSYQDLSDENAKLLQSWQAINTAAKSSSGFYSEQGAQQIIDFVNNQLYPNTKRADQIYVKQRPEFQKGPRPFIDYINPGLIQLKVAVADAAAAVAQRARATQLTPITLAFLNIAQDYSNTQEIQMFGPQTPIYRGQCGCSGQGPQGYFGGGLPGPFGKGPRGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852574.1">
        <property type="nucleotide sequence ID" value="XM_003852526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAX7"/>
    <dbReference type="STRING" id="336722.F9XAX7"/>
    <dbReference type="GeneID" id="13396896"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93307"/>
    <dbReference type="eggNOG" id="ENOG502T257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546545_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAX7"/>
    <dbReference type="OrthoDB" id="3649997at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="54619" checksum="899401388945EE71" modified="2011-10-19" version="1">MSSDAFTNIGEAELRRYAACWLGSELAAQTNWEASHKLFDPEEKMKMASFKQVTQRMLKAYKDKASTTGDAGDNDEVGDGADDDSATAKKKTAAPKKKAASPKKRKVKTEGDEEENAEGEGDGSVEPPAAKKPKASPKKRKTAAEKKAEVAEAAAAKTAADAKAAAEKTAADAEAAAAETAADAEEAAGAEAEGDASLPDALSKSFHWKARSASSPSTQLRILQTVFGESIIRRKRSARAPAMPIISSAGGAYIVELRDPIQEPLTKHLGTRVGVYYGVLLKTPVPVDFKAEAKKKVGHLARFLPPDEKQVKEQAGMPEWVRRRALRWCEAHDSEPENSESPGDGKATMPLDIVVKVFSVLGYGRSHADHEVAALKALTAKECQYTPTYFGNFVLGPDHYVLMSLLPGASLDKNESWRHDEKNVRAAFDRAIKAVHDCGIASKSTNRRNVLWDEIQGKCYIVDFERTEWSHPQDENMARLARQRWIKRGWESFDHWTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB79</accession>
    <name>F9XB79_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_41849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852094.1">
        <property type="nucleotide sequence ID" value="XM_003852046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB79"/>
    <dbReference type="STRING" id="336722.F9XB79"/>
    <dbReference type="GeneID" id="13393870"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41849"/>
    <dbReference type="eggNOG" id="ENOG502SJTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066486_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB79"/>
    <dbReference type="OMA" id="AVTRTWY"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="361" mass="41597" checksum="D8CC6885CB088A3B" modified="2011-10-19" version="1">MKKGLPPCPRTDPIAGLDDWYTITNSPTIDFCPDCISTLFERTFFRPLFRRSLPRNLSTKVQCAFGSPWIRLAWLLTLQQQRADLNLLKDVAEVEATSDPCPGNMPTSQSWYGLRDPDGLFVRDFHICYGDVRKIERLLPTLAGLFVRLPNRASHEPRLCAMRVESTRFSAYLDALVNTHEAALSSRKGADSMPLIDLVERRTRLRECTRDNMLLGALWHTHPDIPSLTICEDCFEEVVEPVIKSALAQPSTSNSFVRKFNRCLGPVYNEGPGSSCQLYSHRMRRCFARSVEDGDGGRYLKRKVRERKEAELWLQEKYREVVRRWKRAESEAGGGEVGREVEERAERELERISREWKGKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM1</accession>
    <name>F9XBM1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_109426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87665.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="535" mass="58388" checksum="1BE5CB9A749AC8EE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_109451</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852159.1">
        <property type="nucleotide sequence ID" value="XM_003852111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBW9"/>
    <dbReference type="FunCoup" id="F9XBW9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="13393935"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109451"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026017_0_0_1"/>
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    <dbReference type="OMA" id="MRFFMRA"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="556" mass="59293" checksum="218E578E8F7962C0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCF4</accession>
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        <recommendedName>
            <fullName evidence="4">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93514</name>
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    <organism evidence="2 3">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCF4"/>
    <dbReference type="GeneID" id="13396776"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93514"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.746"/>
    <dbReference type="eggNOG" id="ENOG502T6T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_4_1"/>
    <dbReference type="InParanoid" id="F9XCF4"/>
    <dbReference type="OMA" id="NARVIHT"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15391" checksum="23D876BE0310D091" modified="2011-10-19" version="1">MSRQSTTINPPNIPEPQPQFSQVNTFTFQPGDKLVAITGQLAIQPNPSDPVPTGFEDQVRLALQNLENCLKAAGATKRDIFKVTHHVVDFDHEKQNPAKVFIDWLGSDFRPASAMLPVQRLAGPGLMYEIETWAIVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ4</accession>
    <name>F9XCQ4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_104737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851947.1">
        <property type="nucleotide sequence ID" value="XM_003851899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCQ4"/>
    <dbReference type="GeneID" id="13393724"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104737"/>
    <dbReference type="HOGENOM" id="CLU_2924491_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCQ4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="61" mass="7426" checksum="6B7776B0A5219DBB" modified="2011-10-19" version="1">MTTTRWLPLSYSISIHFMAAKLRYSADKHFRRRTSFVRSAIQLRSTFRERPHRRLRLAAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA4</accession>
    <name>F9XDA4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CYP-62</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_93864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851482.1">
        <property type="nucleotide sequence ID" value="XM_003851434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDA4"/>
    <dbReference type="STRING" id="336722.F9XDA4"/>
    <dbReference type="GeneID" id="13401541"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93864"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="InParanoid" id="F9XDA4"/>
    <dbReference type="OMA" id="NPKYWPA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="701" mass="78449" checksum="5084D0B0FA449D46" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDR2</accession>
    <name>F9XDR2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_109934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851780.1">
        <property type="nucleotide sequence ID" value="XM_003851732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDR2"/>
    <dbReference type="STRING" id="336722.F9XDR2"/>
    <dbReference type="GeneID" id="13402144"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109934"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.491"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDR2"/>
    <dbReference type="OMA" id="MNALQYW"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390430" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="496" mass="53800" checksum="64D5BE128CA2D7F2" modified="2011-10-19" version="1">MRTIALLPAALLALLPTTLALEPPTPPRPTITTTPSNLTIEHLAGPSTCTRPSRNKDTLSMHYKGTLLSDGTVFDTSYKRNKPFKFLLGAGHVIAGWDEGMLDMCVGEERKLTIPPELGYGERGAGSDIPPNAWLVFEAKLMGIVGVPEANEVAQTSTTAAEVVGAIETAAVAASKDKDKDKDGGDKDDDETPKEPAQCHLLGPYALFAQGGLGALAVLSLVWKRYHETPKRPWKIFFFDVSKQVFGSMLTHVINLGMSIVGSGDFAAQAVEAAKTGGDGKSPNPCSFYLLNLGIDTTLGVPVLYILLKILPALFAYTPLANPPQSIKSGVYGTPPQVTWYFKQLLIYCIGLIGMKIFVFFLFMAMPFLPWIGDWALRWTEGSEALQVAFALFLFPLIMNAVQYWIVDSFIMASTKEGEKESGGVYERVGAGEDEEDDEERGLMGGREVGKGGVEEEEEESRPALTEIQPTPVEEYRDAGSSSGSSPPKVVKQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="274" mass="32024" checksum="3CFAA8D0EBC15B50" modified="2011-10-19" version="1">MERPTTAVQAPVLVTQADIQNAPMSADHKEIVLMHHRRLVAQLPGEFSARQQSALDRLVRITLIFRDYNGYRAKLSAFDEDGSPTTIESMIVDVLDACIPICGVTHPMRLPESGASPREYEVRRMVRQYNNFHSIVEDITRRVRALSKVVPDRHTRVDMAEGIDWPKKLKRARSADDIFQMRFEADVKELAKRLKLEWEEKLRQWHARPPPPFGETLLEREAREREEKKMKEEIEEKEEDEEKRQRDLIVGKLADLSLLWPPGKWEKKEGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="57804" checksum="748B5D7425E0C932" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEU4</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850856.1">
        <property type="nucleotide sequence ID" value="XM_003850808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEU4"/>
    <dbReference type="GeneID" id="13397594"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94728"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.675"/>
    <dbReference type="HOGENOM" id="CLU_054614_1_0_1"/>
    <dbReference type="InParanoid" id="F9XEU4"/>
    <dbReference type="OMA" id="YTETFPL"/>
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        <property type="component" value="Chromosome 7"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="37415" checksum="F23B07CC96D39A47" modified="2011-10-19" version="1">MSTSAETVKAMTAFYQQVVKHLSFDSDALKIAPVEGWPDLDPSVKDKSAAVLELLRHLPYLHLKDPYDLLCVYDSTAAVSYLPGNHRTGAMDDIFPTPSHCVYLTSCVGQHGYSLILDTSKGKIRRVVTVGNKADIEQAHGLALDMDYGAGRGSRAVDEDVCSPSEAVGKIRMADPHRAEERAQEVTPLCEWYPDDLELHRTVGEADSEDFLRYKMVQAQYDVDNYNCYIRFGWPENFDRAACKLEVIKLVKLKDRTQSRYYALNNPETPFNALEEAEEEARVERRWNPQLLERKATGGKAPRKPRPNHSRGLEEIERSAAPRDGDGGQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF55</accession>
    <name>F9XF55_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_45539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850890.1">
        <property type="nucleotide sequence ID" value="XM_003850842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF55"/>
    <dbReference type="STRING" id="336722.F9XF55"/>
    <dbReference type="GeneID" id="13397714"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45539"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="F9XF55"/>
    <dbReference type="OMA" id="GECFYKW"/>
    <dbReference type="OrthoDB" id="3650351at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF29">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="198" mass="21941" checksum="5B742263090B451A" modified="2011-10-19" version="1" fragment="single">YESDSHIYITMEFLEHGDLQKFLSSPLPELEAQTIMFQILQGLKAMHDQGFAHRDLKPGNIMVAAPGPDWWIKIADFGICKRATAGLTELRSVLGTLTYMAPEIHGLIGEDHDARQYTDAVDLWAAGVIAHVILANKTPFPDMGSLTRYATGLSMFPVEPLLAHAISDAGCDFVHQCVMRNPSERPEASVALRHPWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFA6</accession>
    <name>F9XFA6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_105116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850646.1">
        <property type="nucleotide sequence ID" value="XM_003850598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFA6"/>
    <dbReference type="STRING" id="336722.F9XFA6"/>
    <dbReference type="GeneID" id="13397959"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105116"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.203"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFA6"/>
    <dbReference type="OMA" id="PFFYYNP"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000757">
        <property type="entry name" value="Transcription factor Msn2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="600" mass="65446" checksum="7534AFD0D607D728" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFF2</accession>
    <name>F9XFF2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850919.1">
        <property type="nucleotide sequence ID" value="XM_003850871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFF2"/>
    <dbReference type="GeneID" id="13397657"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94825"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.801"/>
    <dbReference type="HOGENOM" id="CLU_900817_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFF2"/>
    <dbReference type="OrthoDB" id="3650933at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36900" checksum="3456E969B7187AA2" modified="2011-10-19" version="1">MEDLTTTTNEHELSSTTTRSYATTEDLTITMNNLYHIYNHLFQPTDDFVRTMNDFYRMYDDFFLATNAGPATNAVYELPEIMENIITHLPTTNILQAKLISQYTNSLITTSPSIIHELLFPTEQAPAAAFVPNALGTTNFFIVDQEKWFIMKPDNLCSLQLAPSERGDIELYYHLHPERHISTILPPLTDAQKQTILFPRKASTRVNVTNWSPLNPSWMWNDLWMTFSIHVKSCRLQDLTNLVEKLNVMLYLINEKEAREVEKADDWKIKLIELVEEKNVVPGPQLTEHEKAMFVDGSKLEVGFGHWWNVLRNEYRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFN8</accession>
    <name>F9XFN8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MgBGL6</name>
        <name evidence="17" type="ORF">MYCGRDRAFT_45540</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850684.1">
        <property type="nucleotide sequence ID" value="XM_003850636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFN8"/>
    <dbReference type="STRING" id="336722.F9XFN8"/>
    <dbReference type="GeneID" id="13397422"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45540"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="InParanoid" id="F9XFN8"/>
    <dbReference type="OMA" id="LDWNAQH"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390499" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="717"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP85660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="803" mass="86564" checksum="FAA94C407171113A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFT5</accession>
    <name>F9XFT5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Geranylgeranyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_110187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851152.1">
        <property type="nucleotide sequence ID" value="XM_003851104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFT5"/>
    <dbReference type="FunCoup" id="F9XFT5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFT5"/>
    <dbReference type="GeneID" id="13397446"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110187"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_0_1"/>
    <dbReference type="InParanoid" id="F9XFT5"/>
    <dbReference type="OMA" id="CHKTFLP"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="8"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="452" mass="49682" checksum="80FC9FC7F21278AF" modified="2011-10-19" version="1">MLEEEPKLDKARHIKYWLRCLKTLLPHHYTGNESNRMYLAFFIISALDLLSAWESSTTASERSEYIDWIYHCQHPRGGFRMWPGTDFGIQSSPENERWDPANIPATYFALSALLIAGDDLSRVRRRETLQWLTKMQREDGSFGETLVDGTIEGGRDPRFGYCATGIRFILRGGREGALSTAGEEIEDIRLDSLVSCIEAAESYEGGLSDSRYHEPHAGYTYCALGCLNFIERLKSIFPPSKHSTNTKPCGPSDPALTLSWLVARQTDLDDPDGELDSCTEDTTSLPDPTVDAPALKQDDARAETETTLHQSPDKSTLTSASLFPTPSLPPLSAGMNGRTNKVADTCYAWWVGASISLLTQAPSPRATQRPPNHMFGAPALQTYLLSKTQHPALGGFGKFPGDLPDLYHSYMGLAALGLIGTEGIKSVDAGMCISAEAEQRVHGLWKEGSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFU6</accession>
    <name>F9XFU6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851146.1">
        <property type="nucleotide sequence ID" value="XM_003851098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFU6"/>
    <dbReference type="GeneID" id="13397886"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94487"/>
    <dbReference type="HOGENOM" id="CLU_680089_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFU6"/>
    <dbReference type="OrthoDB" id="10605746at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="405" mass="45403" checksum="71D2CBBD83898E79" modified="2011-10-19" version="1">MASNDASNGRNHPGKPPLPVRQQQFGKPHARQAQPAPRKQAQGIGKIPRLAPRKAPGPDTLLKTLPKVENDANSAEDSQPFLFHNRQYKVVTKVESFDHPKFKCNTIVMAEFFLVPSDFEGDIPLGTKNAGRQIEYPLQHAQLGSRLTELQVTMKHIYASKTGERRPPFAAHTAEFTADKLHIITEFECDRQYWGTGLAQIAMAGYERAMLKLPQAAGLQTMILSPAPLTDVLDKVQNPHPEHEIVKRLIKSYAKSKYEVWSMPPANLDAGIVIMGKTLAEDAEDAGPVQGPLPRYEGRLITRGYLCRTSSDRKLAVYETGIGRKGTTWKQSNFQAAATQSSSHVVRKIFAESSTRYMIAVHPPVWVRKTRVSQAVISGWEKQKRDQWERRESRRSTSPEPELTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFZ0</accession>
    <name>F9XFZ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_45115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851118.1">
        <property type="nucleotide sequence ID" value="XM_003851070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFZ0"/>
    <dbReference type="GeneID" id="13397467"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45115"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.407"/>
    <dbReference type="eggNOG" id="ENOG502SN9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113367_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFZ0"/>
    <dbReference type="OMA" id="FEYHVDE"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="17420" checksum="8492C47430E3811C" modified="2011-10-19" version="1">MPIWKISHSSTVFTDPSEKASLAREITDWYVNTAKLPDYYVNVTFYKLPVEDFYTAGTSNADKVLIEIIHIARHQDPNNKARSKGMMDTFDGILRPYTLDRGLKLEYNIIDAPAWLWRINGIDPPESFGEGEEEKAEISRKRLAELELGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGX7</accession>
    <name>F9XGX7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_74552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849957.1">
        <property type="nucleotide sequence ID" value="XM_003849909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGX7"/>
    <dbReference type="FunCoup" id="F9XGX7">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGX7"/>
    <dbReference type="GeneID" id="13395037"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74552"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.209"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="InParanoid" id="F9XGX7"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="286" mass="31586" checksum="2FAB4597C3EA56C2" modified="2011-10-19" version="1">MAPTKTKALQSGRPPTIKRPAASLSSSVTQKIIVSFHQLQKQLAQAIQQNNEPTITHLESQIANLGGLKAYQTASIQGQASDRGGDSSLILMVWLSPFKSSLKSLAATKTPLRMLEVGALSTKNACSRSAIFDIERIDLNSQSPGITQQDFMLRPLPVSEDEKFDIISLSLVLNFVPSASGRGDMLRRTTAFLRRTSSVTEVAATLFLVLPASCVLNARYCSEEKLTLIMASLGYVLLQRKQTAKLVYYLWQWRDDPAVEEEQRFKKVKVRDGPGMNNFCVELVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH20</accession>
    <name>F9XH20_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_61964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850242.1">
        <property type="nucleotide sequence ID" value="XM_003850194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH20"/>
    <dbReference type="FunCoup" id="F9XH20">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH20"/>
    <dbReference type="GeneID" id="13394437"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_61964"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.665"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="F9XH20"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905589">
        <property type="term" value="P:positive regulation of L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="188" mass="20964" checksum="28C04464EF57167F" modified="2011-10-19" version="1">MPPQQKQRKMAIVGSRSVGKSSLTVQYVDGHFVDSYYPTIENTFSKVIRYRAQDFAVEIIDTAGQDEYTILNNKHFIGIHGYMIVYSVASKQSWEMVRIIRDKILNHLGADTVPIMIVGNKSDLRPEQRQVQTADGKKLAEELGCGFVEASARYNENVGKAFEGMIGEIEKGQEAGQPKEGNSKCGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHV4</accession>
    <name>F9XHV4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_74360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850535.1">
        <property type="nucleotide sequence ID" value="XM_003850487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHV4"/>
    <dbReference type="SMR" id="F9XHV4"/>
    <dbReference type="FunCoup" id="F9XHV4">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHV4"/>
    <dbReference type="GeneID" id="13395188"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74360"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.40"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_3_2_1"/>
    <dbReference type="InParanoid" id="F9XHV4"/>
    <dbReference type="OMA" id="PIGSWTK"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="577"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="377"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="658" mass="72187" checksum="F2D79D11F61DFDC5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI69</accession>
    <name>F9XI69_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_95233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850342.1">
        <property type="nucleotide sequence ID" value="XM_003850294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI69"/>
    <dbReference type="FunCoup" id="F9XI69">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XI69"/>
    <dbReference type="GeneID" id="13394845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95233"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="F9XI69"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="175"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="658" mass="74518" checksum="068B4E5DF1806E44" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIT2</accession>
    <name>F9XIT2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850260.1">
        <property type="nucleotide sequence ID" value="XM_003850212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIT2"/>
    <dbReference type="GeneID" id="13394427"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95378"/>
    <dbReference type="HOGENOM" id="CLU_657580_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIT2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="418" mass="46606" checksum="F71F4079DC25A20D" modified="2011-10-19" version="1">MVSHAGREVLEVVQRNTGASYPTTADPFPAKFIDFLRTMKPELLAHPTFTEALICAVDRVPGHSKEAVSGALTLASARRPRSARQVYYLRDGPLPKGEYFASDNPDKNRNIVDAGQVIRASTIERLRDDKITFGSPEYVSTPSGPALTKPYLELVLYVIGDVAYCRRITSKGSRGLDAVHKEQKSNYLAILPEVSGEDEAKWDGNEENAHTPTLFTRDMGSHAGSMLCLEETTVSLRSWITPQAGHFSEASLAKIREAVLKQAHVKQHMANFPPRMDRPQGKNVQRKGEFPRLKEEKDKMPNNALRDAPPLTQATPPPARWVNPRRSQRGGRQRGRGQQRQDASRPHVDFNHSATPDFSYGRSQYRDPEPIYNADTTYAPSRASQPPSSRLNTIATGSDIIDQEQPPHKRAKRTHSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIX8</accession>
    <name>F9XIX8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_87533</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849432.1">
        <property type="nucleotide sequence ID" value="XM_003849384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIX8"/>
    <dbReference type="FunCoup" id="F9XIX8">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIX8"/>
    <dbReference type="GeneID" id="13402468"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87533"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
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    </dbReference>
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        </location>
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        </location>
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    <sequence length="411" mass="45824" checksum="DB32DA50F8360E41" modified="2011-10-19" version="1">MDDGYDVPDATDWLETPLKDFASLETALHCQICKEFYDTPMITSCNHTFCSKCIRTSLSADGKCPACRGPDQASKLRNNWAVQEVVSTFITARPAALQVARKALEEEGQKKSGKRKRPVVLDSEDLVEVEGPARATRSKSRRIAASQESHTEAIEIEDSEDGEEDYRSGTPADDGLVACPLECGKRMKAEEVFLHLDKCEDEKKQRSKKASQPSVKAFGATRPPSSQDTRPQDRINELNYSMLKETALTKKLKDAGIPSWGARQGMISRHREWVNIWNANCDSTRPRTKRELLHDLDVWERTQGGKAPTAQGLSSSIMRKDFDGDAYSKRHHDEFSRLIADAKRKKAVPAPDPAVSKGIDESEIQDEHSMRTQPRAIPTHLQMNETKKVPMFQVPEQPLSDLDGGSTSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ89</accession>
    <name>F9XJ89_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_87428</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <location>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="15511" checksum="0B66F96586B014E1" modified="2011-10-19" version="1">MTSINVCKNRSRSNSTMEVPDDERRQSTDNLRRSTTTAKTTTAKTIDPAENAKYCSFYRRLSREVNEKIQEAAYNDDVTVEQVKQESKRKTPPPVLDGPELHDFRKFRKEDFEKFKASKQVYKGAEVVTKKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJG1</accession>
    <name>F9XJG1_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_47515</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849292.1"/>
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    <dbReference type="STRING" id="336722.F9XJG1"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47515"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3847045at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="375" mass="41281" checksum="54F41443AFFCB06A" modified="2011-10-19" version="1">MANLSPPPATRDDFETAIICALPEERDTVEALMTRDFKSEGKIYGKLENDDNTYTLGVLGNKPVVLVAPRDMGTTNTRDLARGLKISFSKVTWAFVVGIAGGAPFVPDGPGWKKSGIQLGDVVVSTQVIEYDFGREFENGFKRKTEVESVLSRAPQKVANFINQFKLGRSAAFRRILAKTNADLTTGKGEDHEHPGANADHVYGLGYRHKHQDPEACTKCSQCTEWYHEVCATALTADCLTLGCKPHHSNNDIKEAQIHFGRYASGNAVMKSGHRRDLLIRDEGVIAFEMEGAGAWEVFGTIVVKGIVDYADSHKNKKWRGYPAARAALCAAAMIEEIELPEKPRPGQRLATLFLRLDNLTVHFSPAYLAPCSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJI8</accession>
    <name>F9XJI8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_30166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849355.1">
        <property type="nucleotide sequence ID" value="XM_003849307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJI8"/>
    <dbReference type="STRING" id="336722.F9XJI8"/>
    <dbReference type="GeneID" id="13402559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30166"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1055850_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJI8"/>
    <dbReference type="OMA" id="NTCAYVT"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29568" checksum="9271F16D96C3C181" modified="2011-10-19" version="1" fragment="single">ELMFRDQYLSRADMWQLLGRVQDTVLYRGQVLNYLGNATAEVKHIYISGNEVESGFCSHPQTKAIFRSASARYTILVEISQEMLSSWSNGELMYERLLNGFLPDLFNRWKTLKVRHQVSVILFGRSKVANGNGKHDSYESGHGEDFFHVLVSEIVSSNWPLIIRKLKQAFNDRTLSRAVSLAAESNMLEAIHLTALDFSDDQTDTHLMSTGTSIIAVTAGTGLFDADHTLLKQTTDLLIGNSIGVDIVALSPRPLTPVPLFKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJL5</accession>
    <name>F9XJL5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_75758</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849474.1">
        <property type="nucleotide sequence ID" value="XM_003849426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJL5"/>
    <dbReference type="FunCoup" id="F9XJL5">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJL5"/>
    <dbReference type="GeneID" id="13402435"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75758"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.455"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJL5"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="108"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="560" mass="62602" checksum="E236A769258302F6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJN6</accession>
    <name>F9XJN6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_47503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849488.1">
        <property type="nucleotide sequence ID" value="XM_003849440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJN6"/>
    <dbReference type="FunCoup" id="F9XJN6">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJN6"/>
    <dbReference type="GeneID" id="13402428"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47503"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_2_1_1"/>
    <dbReference type="InParanoid" id="F9XJN6"/>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="297" mass="33436" checksum="32F39CAF9333E1EF" modified="2011-10-19" version="1">MAANYWDSTQAKFWTFAKAELSDLRKDLEKTNQPLHNRYTLPDRRLMNIYIQQQLVKLARRMSLRQQALATAQIYIKRFYLRVEMRKTNPYLIMATAVYLACKMEECPQHIRLMLGEAARQWPELGVTETSKIGECEFALISTLSSRLICHHPYRSLSELGPIFGLSSEETQLAHSILNDSYNTDLPLLYAPHIIAITAVFLAVVLRPSGQPPVSGNAAQQAFLGGFSGLKQAGPKLSKLVDWLAESKVDMNSIVDATQELVSLYEVWESYSERTCKEAITKFVKDAGMAGGGLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJV4</accession>
    <name>F9XJV4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_75286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849279.1">
        <property type="nucleotide sequence ID" value="XM_003849231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJV4"/>
    <dbReference type="STRING" id="336722.F9XJV4"/>
    <dbReference type="GeneID" id="13402632"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75286"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.52"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJV4"/>
    <dbReference type="OMA" id="YNRYRFK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF140">
        <property type="entry name" value="FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391707" description="FMN hydroxy acid dehydrogenase domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="391" mass="43058" checksum="984BA00C85BB5BAF" modified="2011-10-19" version="1">MRLLTSLLLSAAATLTQAARPFLEEPETGQTTTFANVSSSESSLPNLEDVWALSDFQHIAERHMNTTAYTYYRAAAAGEFSYRNNLETFARLRLRPRVMRNINNISASLPTPILNHTFSAPFFIAPAARAGYAHPDGELALVRAAAEENILYIPSDLSSRSKADIQSARAEGQVLFQQLYLDPLNTTATTLQIREAESLTFQALILTVDSPANNVRHRAWRYGVGSADDALTSLTWDQWAELQATTRLPIIPKGIQTWEDAVIAHSYGVRAIYLSNHGGRAVDTSPSPLEVAIEIHQNAAWIFDEVEVWADGGVRYGTDVLKFLALGVKAVGLARPFMYANVYGEDGVRKAAQLLKREVMLDAANAGIGDLKQMNSSWVDVEGFPNAWGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK59</accession>
    <name>F9XK59_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_75892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849596.1">
        <property type="nucleotide sequence ID" value="XM_003849548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK59"/>
    <dbReference type="FunCoup" id="F9XK59">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK59"/>
    <dbReference type="GeneID" id="13402393"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75892"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.550"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_2_0_1"/>
    <dbReference type="InParanoid" id="F9XK59"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="247" mass="25031" checksum="953C3670B42A5C71" modified="2011-10-19" version="1">MSGKLAQSLDTIMSENKTGNGGKRRGGRAPRKAAVKATAVIVGGVQKTRGGKNTTKAVAAAPLTGETKISVSNLPEDVSEMLIKEYFSSTVAPVKKVVLNYGPTGRSRGSAVVSFNSANAGAKAVALDGTKVDGRPLRIEILVSAKAVPNVAPKSLQDRVSKPKNAAKPNGKETAGAKDAAAGAGKGGRAGKKTGRVNKPKKTAEELDAEMQDYFGGDSNGAATNGTAQPAATAATNGDTGMVDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK74</accession>
    <name>F9XK74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_75552</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849720.1">
        <property type="nucleotide sequence ID" value="XM_003849672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK74"/>
    <dbReference type="STRING" id="336722.F9XK74"/>
    <dbReference type="GeneID" id="13399088"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75552"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_0_1"/>
    <dbReference type="InParanoid" id="F9XK74"/>
    <dbReference type="OMA" id="EYFLHQQ"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
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        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="721"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="922"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="478"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP84696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="924" mass="100886" checksum="E544CFD0FB755A79" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP2</accession>
    <name>F9XKP2_ZYMTI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_48449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKP2"/>
    <dbReference type="GeneID" id="13398020"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48449"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="F9XKP2"/>
    <dbReference type="OMA" id="VNFSSIH"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="27879" checksum="E3FDE48C4D50F3CC" modified="2011-10-19" version="1">MSLQNRTILVTGGGRGIGFAICKAIAQMGGNVAVIDTLEKPANEFHTLKERFGVEAFYFRGDVTKQDSLEQAFEGTVQSAGEINGCVTAAGIVIDKPFFDHGWEECMRVLAINVMGTFWTAKLVSQHMANHGKGGSLVMIASVAAQGIKIPQQQISLYNMSKAGVKGLVGPLSVEMAVNNIRVNSISPGVIMSPMTEGLKTMYPELLKMFENAAPARRIGMPADLTPAVIYLLSDAASFTTGADLPITGGLHAGTSMEWLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKP6</accession>
    <name>F9XKP6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_105922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849145.1">
        <property type="nucleotide sequence ID" value="XM_003849097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKP6"/>
    <dbReference type="GeneID" id="13398617"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105922"/>
    <dbReference type="eggNOG" id="ENOG502S8T0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387264_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKP6"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="197" mass="22297" checksum="5393ED1D6C7E2358" modified="2011-10-19" version="1" fragment="single">MSGNSRREQAAGRHERTDSSWTDRSITSRLGTGYSNMESISPTSSHFMPAVFRARTRKLVKDGRVNKFASKKRMSSTRGRDRDSNAGRDSMAITALSDQPRNPDDSAEYLPSGQPKYGRLKDSSPTPGQKRRLPRKYSKQRLWNQMEFPRPMTSDRLSSLGVEPRLGPPTRSSQQGLPRWYAPSFVESLDTLIKSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL13</accession>
    <name>F9XL13_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_48403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848774.1">
        <property type="nucleotide sequence ID" value="XM_003848726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL13"/>
    <dbReference type="FunCoup" id="F9XL13">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XL13"/>
    <dbReference type="GeneID" id="13398761"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48403"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL13"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="217"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="805"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113728" checksum="1EC2F131B072E33A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL21</accession>
    <name>F9XL21_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849210.1">
        <property type="nucleotide sequence ID" value="XM_003849162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL21"/>
    <dbReference type="GeneID" id="13398757"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96071"/>
    <dbReference type="HOGENOM" id="CLU_772088_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL21"/>
    <dbReference type="OrthoDB" id="3645423at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="359" mass="40696" checksum="939F31A28C4B6E07" modified="2011-10-19" version="1">MAYDPDDSDWSGDSDDSDDDSSDSDSPLPLITFPWLTGYPPTKPNASTTFLDLPVELRVRVYELVFHGAEQHLAHFTEPPLLKIYPALRAEMLPEYLKSAKLIVIVRTNLESEEEPSEVIVPNHFARAHFGNDYDLPAGKLGLRRSLKTKLDARHGTMEPVVYHIDFRSYSYSTTLDVDEKVDPDDMYYDEVRLSGSDTPPPGRPYHHDSSITLHWDPVDGLRVSKLEPVHSGYDRNFLDVWNDKVAVPIRALAWDIVKRPGFCGFTLKDIKEVAREFRLDDPMWKRQVALYMYTGARVSRLREMSFLDGDDAFTARGCLAIRGHRWSNAHIEAEAGTEQGKAPPSIRSRSVHGRTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLT9</accession>
    <name>F9XLT9_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_48728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848943.1">
        <property type="nucleotide sequence ID" value="XM_003848895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLT9"/>
    <dbReference type="FunCoup" id="F9XLT9">
        <property type="interactions" value="1172"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLT9"/>
    <dbReference type="GeneID" id="13398188"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48728"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.433"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="F9XLT9"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="936" mass="104662" checksum="6F3660DF1B0CFB8C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMG1</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848268.1">
        <property type="nucleotide sequence ID" value="XM_003848220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMG1"/>
    <dbReference type="STRING" id="336722.F9XMG1"/>
    <dbReference type="GeneID" id="13396355"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82501"/>
    <dbReference type="HOGENOM" id="CLU_1582471_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMG1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="16400" checksum="75BDDF4E58C9E6D1" modified="2011-10-19" version="1" fragment="single">MPSGNPIQSYNYTIPYSTGSSVGSPITASAPSSAASTGAIPTYSNLTSSATLTSFVTFTILPTGSPAIPSNSTASTPFSPITASLNGTSSGFASPTGTGSPITASAGFPTAYPFPIVSTGVPSSPSGSLGSPISPGNSTSSASVTDSPTLPTDAPGGTTTVFVTVFPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMT1</accession>
    <name>F9XMT1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_106099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848665.1">
        <property type="nucleotide sequence ID" value="XM_003848617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMT1"/>
    <dbReference type="GeneID" id="13396541"/>
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        <property type="component" value="Chromosome 11"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390893" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
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        </location>
    </feature>
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            <begin position="84"/>
            <end position="95"/>
        </location>
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            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
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            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="14371" checksum="1F88A16C4295FAE0" modified="2011-10-19" version="1" fragment="single">MILNKALLLSLTATCAVHGAALAMPQLQGLDSLVKPVTDTVETVKQIAGLPGTSTDGGKFGPKWINDVAKRDEPEPVHQAQAKPVDDGDRRRDAPQLESRQSNSRQKLAQMHGTYRQNTLAKLSDSGKCNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="F9XN32">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN32"/>
    <dbReference type="GeneID" id="13396515"/>
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    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9XN32"/>
    <dbReference type="OMA" id="MNEKACV"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="214"/>
        </location>
    </feature>
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            <end position="256"/>
        </location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="289" mass="32304" checksum="A8E36248016F853C" modified="2011-10-19" version="1" fragment="single">IHSGDSGIWVTCGKGREGKCVMEMRDLFNEYAKEMYPQSADGPDGGEGDAEGEMDIEREIQAELDEMKKPARGQLFTHVRVNLQCVVFFKTIAPVVPTDLVKRICEDAMNNSAIKRTRFAQRLTPMTLMGRASAEGLEKVCLEVLAPHFHQEPFQRRKFAIRPTLRNHNLLSRNDVIKQVAPLVGRGHEVDLKNYDLLILVELYQHVCGVCVVDTDYERLKRYNISEIYEPTPPQEPNVAATAKAEKGAQDETTDEVVVKATDEDSEQADVEAKGEAIVGAMEDVATEV</sequence>
</entry>
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        </submittedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847894.1">
        <property type="nucleotide sequence ID" value="XM_003847846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNG8"/>
    <dbReference type="GeneID" id="13401775"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18237"/>
    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNG8"/>
    <dbReference type="OMA" id="FEWYPHY"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="219" mass="23957" checksum="89D6839F252E3251" modified="2011-10-19" version="1" fragment="single">TSPSFDILEWHPAYQSCQRYFLDHAQHDPGTQAVCALINIRLPFQWLGSPVTSSSHTNHAFTFSSGNGPSNMRLNPSPSRAAGPPIFVSPIPYIRRLVVTGFDKPPILHGFFGDDYVKGIMPHVECERRNYLFAAKSGGWRSCKRAYDVGSGGGVGGGAGGDETVPFMKALKDVPAEGVRAAEADWSRWLGMEDWMVGEDGPEVKREDQGDEMESAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNS5</accession>
    <name>F9XNS5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_50790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847949.1">
        <property type="nucleotide sequence ID" value="XM_003847901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNS5"/>
    <dbReference type="ESTHER" id="zymti-f9xns5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13401955"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50790"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_7_1"/>
    <dbReference type="InParanoid" id="F9XNS5"/>
    <dbReference type="OMA" id="YICPGID"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130638" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="31"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="536" mass="58154" checksum="3F440A225175EBC3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNS6</accession>
    <name>F9XNS6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_106353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848142.1">
        <property type="nucleotide sequence ID" value="XM_003848094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNS6"/>
    <dbReference type="GeneID" id="13401956"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106353"/>
    <dbReference type="eggNOG" id="ENOG502SQKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077468_1_0_1"/>
    <dbReference type="InParanoid" id="F9XNS6"/>
    <dbReference type="OMA" id="SFLNCIG"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="239" mass="27237" checksum="45C4482AF1F830DD" modified="2011-10-19" version="1">MPMAYNSPPNPPAMQTWAERDIVALDRLPEPVRCRIFEIVLRVRHPLYLFQDSPTRVELFAPEKPRNWHGLLRINKRLGLEASAVLYSKNTFILTVTSPREADLLETFLRCIGPKNASFLEHLCISFPAVELYQSDEPQADSFRLRQDSARVFALLKDQCTSLSTLELCVHSKNCDGMTSTSPGQRQHIPEMLSYVERHFREMQMLGRIIIKISSGDLLPETVDAMRGHGWVIAPGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNU2</accession>
    <name>F9XNU2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848132.1">
        <property type="nucleotide sequence ID" value="XM_003848084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNU2"/>
    <dbReference type="GeneID" id="13401634"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97078"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.248"/>
    <dbReference type="eggNOG" id="ENOG502SA0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_2_2_1"/>
    <dbReference type="InParanoid" id="F9XNU2"/>
    <dbReference type="OMA" id="PQWFEYI"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="313" mass="35576" checksum="A6269AB06B6C2263" modified="2011-10-19" version="1">MKAKEEPRSFPLEDKPLTRENILKCLSIAPRVPPSGWGSMVARLRSDVVVKYGQERVHINEANTMRLVRQRTSTVLLPKVLDAWTATDCGQNRRERGKEDVPVTYIVMQYVHGTVLKDKWPTLIGTERDILVQRVADMLKELRTVQVDQPGPLGQPIRCEGRYFTEYDAGPFETKADLTHWLNNRLEVCKLFRQAPQNRPELAIDELVVCHTNLNERTIVVAADGSPWIIDWTCAGGYPPCFERGSLRPIHGDAGEFARALKEKIAFEEDEPLLARLDELTFAFYTAALCRRYDMDFGRDDSEGSETDSLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNU5</accession>
    <name>F9XNU5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_111494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847957.1">
        <property type="nucleotide sequence ID" value="XM_003847909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNU5"/>
    <dbReference type="STRING" id="336722.F9XNU5"/>
    <dbReference type="GeneID" id="13401632"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111494"/>
    <dbReference type="eggNOG" id="ENOG502R9PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092270_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNU5"/>
    <dbReference type="OMA" id="LIMVECH"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="28932" checksum="43A14D600F73779C" modified="2011-10-19" version="1">MPCEQMVFTLNETKPDDASSASRAVVEGDTYVSVTEPEMNQLLQPLGKRVVKPTEAEFSSSIPQSHRKGEKAYHVKSHRGTKEGYLFFLSNGIVFGFKKPLSFFPFSVIESISYTSVLQRTFNLVITSNEGDSAETQDTEFSMIDQADFGGIDEYVKRHGLNDASLAANRRAKAYNVNKTKAEVNGDAGGAENGVEGEESELAKAEQALQDAEDEEEEDYEASGGESEGEYSDEDDEDGEEYGDEVDEEGGDEVEHDEDALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPH2</accession>
    <name>F9XPH2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848226.1">
        <property type="nucleotide sequence ID" value="XM_003848178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPH2"/>
    <dbReference type="GeneID" id="13401506"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96914"/>
    <dbReference type="eggNOG" id="ENOG502SUP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802163_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPH2"/>
    <dbReference type="OrthoDB" id="3648790at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="339" mass="38121" checksum="49D87E40C8F3E186" modified="2011-10-19" version="1">MENQMDPPPAYEATEQEAFLSQARAADQDALLDRLTDHIRRQRIQNIAESLDTSAEARSALEFETRRIRSMLKFTLAADYQIWDSAPNLSAVDREHFLFMVRATRELESALPVRPTPEERQVLAAYFWKHLHQPCKALSLPLESVFQSIVDLSEFVNAKGHYKGSVQGILHTRGFKGLATKLWMDCEIVIPAVFDTGTEIDESLALHLKARNYCLRAMYFKRIYGVKAESSVRSIDAARAGLPNADRPRQAIMYSANERGIAYASSRKAAILAMGKDLTSAEWMGKVGACVHNVLRRVEMWQSGVPDSVEVRRGAKRIVPEEALGEPHSCVSLFRLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPX8</accession>
    <name>F9XPX8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF171-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_15728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847570.1">
        <property type="nucleotide sequence ID" value="XM_003847522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPX8"/>
    <dbReference type="FunCoup" id="F9XPX8">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPX8"/>
    <dbReference type="GeneID" id="13400792"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15728"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_2_0_1"/>
    <dbReference type="InParanoid" id="F9XPX8"/>
    <dbReference type="OMA" id="FFPIHKD"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33347" checksum="AEE9E0C900983680" modified="2011-10-19" version="1" fragment="single">SKPSAVFKPAGGRSHTLSIALPGSIIANAVTPDQKTSLAGQIARACAVFCVDEIVVFNDGQAETRAPEPSGYTAFTDPNFFLYHVLTYLETPPNLRKSLFPMHPDLRTAGALPSLDMPHHLRSDEWCEFREGITTGPGKRGTTLVDCGLGRKVSIPVEIDPSTRVTVQLPQSLPTGDTISGDAVAPDTPREQAGYYWGYQVRQAPSLGSIFTECPYDGGYDISIGTSERGTSLDSLTDTSSPSHVAPTWNHLVVVFGGVAGLESALKADAELQAAGVTQAADVFDCWINLVSGQGSRTIRTEEAVWVGLTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ29</accession>
    <name>F9XQ29_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_30788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847593.1">
        <property type="nucleotide sequence ID" value="XM_003847545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ29"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30788"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_084247_0_1_1"/>
    <dbReference type="InParanoid" id="F9XQ29"/>
    <dbReference type="OMA" id="AEHWMMF"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADAR"/>
    </dbReference>
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        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="163" mass="18642" checksum="BDB89472CD829099" modified="2011-10-19" version="1" fragment="single">DTLFFWKEDAPNGFLCQWYRATFTDPSTNQIFTSAEQWMMYHKALLFHDQDTAALILKTTSPRKQKGLGSQVSNFDEAVWQREREGIVEKGNVLKFGQATDAVALKGLLLGTGERELAEASPFDRVWGIGYREEEAGRVERGKWGENLLGKVLMRVRERLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQA6</accession>
    <name>F9XQA6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_106533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847713.1">
        <property type="nucleotide sequence ID" value="XM_003847665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQA6"/>
    <dbReference type="FunCoup" id="F9XQA6">
        <property type="interactions" value="1021"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQA6"/>
    <dbReference type="GeneID" id="13401163"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106533"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.287"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQA6"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="194" mass="22162" checksum="CAD98FC67D795578" modified="2011-10-19" version="1">MAPRSYSKTYKVPRRPFESARLDAELKTVGEYGLRNKREVWRVGLTLSKIRRAARQLLTMDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKVEDFLERRLQTCVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALTSPFGGGRPGRVRRKKAAAAANKDAGGDDAGDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQF2</accession>
    <name>F9XQF2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_77999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847655.1">
        <property type="nucleotide sequence ID" value="XM_003847607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQF2"/>
    <dbReference type="GeneID" id="13401327"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77999"/>
    <dbReference type="eggNOG" id="ENOG502S3SI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XQF2"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="26080" checksum="DF644EFCE6889487" modified="2011-10-19" version="1">MSWWEKYFAPGDLRTQVNNQLAENAKLKDELDSVPAQPALPKRIDAAHRARRQNAMFFGGLAFTCLTALVTRRALTKKKLAMYPHLQPTVGKDAKLELPKFTPSNTPPKAEGGLDAAEALFLATLNVGAVFMASVGAFMKFADVADTEDLRDYVRSGIGYDVYAGDTEADREIEQWFAEVLSRKDGTGDLKTTIVEKMAELADIEKKRKAEVGDTELADIQRKRKALEKISAEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQQ5</accession>
    <name>F9XQQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_88521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847421.1">
        <property type="nucleotide sequence ID" value="XM_003847373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQQ5"/>
    <dbReference type="STRING" id="336722.F9XQQ5"/>
    <dbReference type="GeneID" id="13400559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88521"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.71"/>
    <dbReference type="eggNOG" id="ENOG502S879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQQ5"/>
    <dbReference type="OMA" id="TPWHEAF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="151" mass="16647" checksum="33DE0415D5B8E884" modified="2011-10-19" version="1">MSSKAQPDTEKPWHASFPPPRSNAGTMSPEQLLELLQDERKLPGRDFLLIDLRRSDHKGSTIRGSLNLPAQSLWYSLDSLYELCQAAGVSTVAFYCGSSRGRGNRAACWFQDVLARRGETNMKSFVLAGGIDGWFEAGGNYANFVDGKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRG4</accession>
    <name>F9XRG4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847155.1">
        <property type="nucleotide sequence ID" value="XM_003847107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRG4"/>
    <dbReference type="GeneID" id="13399698"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97815"/>
    <dbReference type="HOGENOM" id="CLU_2199077_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRG4"/>
    <dbReference type="OrthoDB" id="5424577at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="12349" checksum="360B16718A666920" modified="2011-10-19" version="1">MSNVSTPRNHKMKKSTNEFGFERTPSNWSAVPTLVEWVKMLFLAYGQNQSERGENGILRKQGLGRRRSRITSMEDDPRFLLTAADSDDDLPPVTDLLRDHPRLDAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSB5</accession>
    <name>F9XSB5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846889.1">
        <property type="nucleotide sequence ID" value="XM_003846841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSB5"/>
    <dbReference type="STRING" id="336722.F9XSB5"/>
    <dbReference type="GeneID" id="13396644"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98106"/>
    <dbReference type="HOGENOM" id="CLU_1422479_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSB5"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="191" mass="21433" checksum="E72846C249579D3B" modified="2011-10-19" version="1">MVTYTVKRELGGACTFAPVHLIENSTALAMEEEDNVDENMPVARVGKDSHRAFKVSEAIKMEEPTSTWEFFILRSGAERVEQEIANDDDDDDDVDEDAEEDDEAKRYCPRCFGGRVETERRSAVVVVFEPRVSEVVKVVKVVKVVKYAGVRACRVMHTLMPLKLKFHQTFDNTKGNHGQPTNTIASLPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5I3</accession>
    <name>A9Y5I3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cox2</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="19"/>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648754.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5I3"/>
    <dbReference type="FunCoup" id="A9Y5I3">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="336722.A9Y5I3"/>
    <dbReference type="GeneID" id="5846256"/>
    <dbReference type="InParanoid" id="A9Y5I3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.90:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0186">Copper</keyword>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="18">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="17">
        <location>
            <begin position="110"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABU40270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="249" mass="28571" checksum="E9A3BB921434AF88" modified="2008-02-05" version="1">MNLFNNFTISLDAPQPWGVYFQDSASPQMEALIELHDNIMFYLVIILFGVAWIMVSIIRNYISTKSPISNKYLNHGTLIELIWTITPALILILIAFPSFKLLYLMDEVTDPSLTVFVEGHQWYWSYQYPDFLNNDDEEVEFDSYLVPESDLEEGALRMLEVDNRVILPELTHVRFIISSGDVIHSYACPSLGIKCDAYPGRLNQISVMINREGSFFGQCSEICGILHSSMPIVIESISLEKFLSWLHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWN3</accession>
    <name>F9WWN3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_66333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857299.1">
        <property type="nucleotide sequence ID" value="XM_003857251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWN3"/>
    <dbReference type="FunCoup" id="F9WWN3">
        <property type="interactions" value="1026"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWN3"/>
    <dbReference type="GeneID" id="13402870"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66333"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1127"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="F9WWN3"/>
    <dbReference type="OMA" id="GASFFRY"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="252" mass="26069" checksum="29E93FEC70E6A330" modified="2011-10-19" version="1">MADASAPKPSSSVKLVLLGEAAVGKSSLVLRFVSNAFQPNKEPTIGAAFLTQKCTLPNRIIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDITKASSLVKARHWVAELQRQASPGIVIALVGNKLDLCEEDGEGGENSTGEADTEGEDTPEGEDVDAAARKVSKAEAKRYADEEGLLFFETSAKTGENVSEVFTAIANAIPEASLKGARAGATGGGGATQAALGSGAAGGDANRVNLNAKDSGAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWW9</accession>
    <name>F9WWW9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysophospholipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856611.1">
        <property type="nucleotide sequence ID" value="XM_003856563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWW9"/>
    <dbReference type="STRING" id="336722.F9WWW9"/>
    <dbReference type="GeneID" id="13398859"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89921"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676537_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWW9"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45797" checksum="0A36B9142D895BE9" modified="2011-10-19" version="1">MSVHQCDTETAAQRIYEEQLHTSGHLDDSMDECSDRMDKTSSSSITQKKGYAKTRMSTFCHKFVKPAFPEAITDIKILHGMTALERRVKNEINDAGLCPEVAKMAQVRRGLELCPEERAFLVKRKQHVRDHFAKYLGLNPQEVHPDDVPRISFGGSGGGFRAMIGVLSYADEMKAAGPLDCLTYVYLRCSQQDGSSSRTTQLHIQVVLLIMKLLDFRPPGTSSLLRESLVPTWAFGRPFEHGRSTMQLPEQSLALLLGLATNAPAGPRTSYIFTISRNLPVGFLGSSVHTLAHGLTRLWGKEGTEEFQNHHPLHACNEHNFMYHYTPVKPDAHRAPGLENSPRIHLIDSGMDNNCPTVVLLHPQRKCDVMINMDASSDVQKDTFRERVDQIKARLDIYETPRHVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX40</accession>
    <name>F9WX40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_34239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856703.1">
        <property type="nucleotide sequence ID" value="XM_003856655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX40"/>
    <dbReference type="STRING" id="336722.F9WX40"/>
    <dbReference type="GeneID" id="13398109"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34239"/>
    <dbReference type="eggNOG" id="ENOG502SRKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070871_3_1_1"/>
    <dbReference type="InParanoid" id="F9WX40"/>
    <dbReference type="OMA" id="ICSADCA"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="22646" checksum="482D27B77892BD06" modified="2011-10-19" version="1">MSSNPISQAAYAHAAAELHPSILAHSLRVHLHATQISKQEDLNWHTDSKQSTLLFVACIFHDLGTSSTYDTGPTRFEIEGADAAVNFLKQYPTITEAERHEVWTAIAIHDTPQIAERISVLPRLVRLGVTIDFKRPAALAMVSEKWVKHVETEFPRVEIEKVLGDAVVEQALKVPEKAPAACWPGLLLRAKLADPEWEGVNKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXL8</accession>
    <name>F9WXL8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_33464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="369" mass="41673" checksum="065F37CA37528107" modified="2011-10-19" version="1">MALDEPSAQLNAELRSSVVDSLASRRPVLHHLNDDTTWLLQIPRPEAAVRHGARLYYNILIDPWFRGGQTDIASWFSRQFHATPSAVQSIAELEELIREVERSAMESEPAVNKRRTRDLEDFVAAEESLIDAIAINHEFTDHCHKETLLEVNRNVPIFAWKEAVKMIESWKHFRSVTAIVEFGSDCDSDWRNTSIPPLPEWIGISRLTKSDLHAAMMITFNNRHDESAEALIYTPHGLPSSDFQIVRDASPPISCLALLHGLHNVRLGTATGLTALQINLGSHNGLRSQRMLNADYWIGTHDEDKKGRGLIAWFLQRDILTVRDALLQEFKARRGGKGDALDRDVVTVLDSFEAANWVDLRNGESHVLL</sequence>
</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="338"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="881" mass="99132" checksum="D29DF94CD710A933" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031505">
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    </dbReference>
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            <begin position="223"/>
            <end position="245"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="306" mass="33429" checksum="FCD31040AD8B9D9D" modified="2011-10-19" version="1" fragment="single">MGKAGRAACILTPMLLTLASLICLLLVQLGGINKSNDTLNSMSFFTANLTNFTSTSISGDSTLALALQQVQDTGSVADIYQIHLWNYCTANSSADGDTDMDKCSKRKQNFVFDPVKVWGLEEKILGKSGKEALHAYRTVAKWMFIAYQVAFWTTLATLVVGIFAVFSRIGSLCTWILALISTLFTFIAVLMSTILFSVLVPALNKVLDDYGIKLSLSTPQLTVVWLAVAFSLAGSLFWLFSICCCSGRSNPHHRSNKGGLWNAEPKGQGYGVADQQHHAAWAGERRSRGLQVEKTGGDYERVTSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857247.1">
        <property type="nucleotide sequence ID" value="XM_003857199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZD0"/>
    <dbReference type="STRING" id="336722.F9WZD0"/>
    <dbReference type="GeneID" id="13394972"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28186"/>
    <dbReference type="eggNOG" id="ENOG502SGAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067596_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZD0"/>
    <dbReference type="OMA" id="RYKLHVA"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP92223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="18876" checksum="E46F5BAF00B056CF" modified="2011-10-19" version="1" fragment="single">SRFVPGGTNEEPTERDEAWLKAQSELDARRAEKAAQAQANSGKSLFETLEANKAAKQDAFEESIKLRNQFQALDEDDVEFLDSVLESTRKQEAAVRKQTREELEAFKRQQQEAEQAAKVMDVLPEPPVETSSWTVSRKRKKGREDVLGGVKLRKASSGAKTPGEAVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZF9</accession>
    <name>F9WZF9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857788.1">
        <property type="nucleotide sequence ID" value="XM_003857740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZF9"/>
    <dbReference type="GeneID" id="13403773"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88627"/>
    <dbReference type="HOGENOM" id="CLU_2199074_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZF9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="11594" checksum="E085C273EA577761" modified="2011-10-19" version="1">MSTCLLIPRALLAACPLPTAVEKQKGMAKLMKKARNQLHDVRNGIEVGGNADPGGTDLICYRSSIKPLEAGPFESAIRRNRTSEEDCVETLKCPAHNMMMLPASNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZJ9</accession>
    <name>F9WZJ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_88664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857768.1">
        <property type="nucleotide sequence ID" value="XM_003857720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZJ9"/>
    <dbReference type="GeneID" id="13403339"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88664"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.93"/>
    <dbReference type="eggNOG" id="ENOG502T8RE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1788350_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZJ9"/>
    <dbReference type="OMA" id="RCKSWIC"/>
    <dbReference type="OrthoDB" id="3621537at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389814" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15543" checksum="E62FFB79A564764F" modified="2011-10-19" version="1">MHLSLPFLFLTSILPLISADFLVANATACTGAFPINTCTHGVKVLSGTNNATEYTCDHLIRAQDNNYLSGGTAGPHGMNVVAKQGICDSGRLEFVKDGVGYEVRDASGGHLGDCTLTDQWNRSCDMWIGVTYFESMYYCTSGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZN9</accession>
    <name>F9WZN9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_31926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857696.1">
        <property type="nucleotide sequence ID" value="XM_003857648.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31926"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.259"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_4_1"/>
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    <dbReference type="OMA" id="MRYFSPY"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Main.1:_Beta-like"/>
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        <property type="entry name" value="Main_(cytGST)"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25344" checksum="9B8DEE5B286F115D" modified="2011-10-19" version="1">MGLIVHHLGHSQSDRVVWLCEELGLTYELKKYDRSPVLSPPELKALHPIGASPVIEDDGGVKLAETEACVEYICNIHAGGKLLVQPGAKNYADYLYWYHVTNGTLQPAVGRVMALSMAGLKEDNPTLARYQAKVHQVLGYMNERLGSVPFFAGEEFSAADIMAIFSLTGMREFCPVDLSEYKNLLSYMQKIVKRPAYKAYLSKGDPGIDIEQFIQGPPPPLFKGFAGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X046</accession>
    <name>F9X046_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Autophagy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_66163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856307.1">
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    <dbReference type="STRING" id="336722.F9X046"/>
    <dbReference type="GeneID" id="13402930"/>
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    <dbReference type="eggNOG" id="ENOG502SDD8">
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    <dbReference type="OMA" id="GTFSRCF"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39630" checksum="E0087D76C0DCE88C" modified="2011-10-19" version="1">MGWFWDSKGDDPTNDPYKKLDPTLREFLDKESPLKYEDTKPKPKARQPPPPSPDGAPNTFRSQLGLDTPGLDQQNQDTVQSHDRPEVPAESLFQDGRYAHLWKNYRPQSEVEAGGKTDQDRLASVIEAYNDRKAAIGRAALENCVEYQLAEKDCFSNGGWAKKMTMCRDESKAFNRCYTMQSRFLKALGYLASQRTEEEDERIQMHADKLYGEMLHREQVQQEAKEAGQEVPDLPPLIQAESTTKALGQNSAWARARQTALEKGLPTNLSAFSPEKQAQIKERIKGLSKEEQELELQLIAGESRAQFEYADKIAQQLEEEKAHRADRRERGKETIGDTIKRLWGWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X067</accession>
    <name>F9X067_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_98514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856316.1">
        <property type="nucleotide sequence ID" value="XM_003856268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X067"/>
    <dbReference type="STRING" id="336722.F9X067"/>
    <dbReference type="GeneID" id="13402918"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98514"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1018"/>
    <dbReference type="eggNOG" id="ENOG502R3Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_0_0_1"/>
    <dbReference type="InParanoid" id="F9X067"/>
    <dbReference type="OMA" id="RPIPKCL"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="325" mass="37166" checksum="2A95079C359E20BB" modified="2011-10-19" version="1">MSKRPRTLDGFFASTPAKKQKAEPESISTTAKTVKDVDVAASFSRHQQYPFPLPDLPPNIRDLINFVPAADAREINNQPDLDLLYFQPYIPKEIERDLFEFLRSQLFFYRVKYNIKRGPVETQVNTPRFTTVFGVDDTSRFDKGNLIDAASGKPVPHNAYKSKPRPIPECLNVLRRLTENVTGFSFNYVLVNYYASGDDSISYHSDDEKFLGPDPAIASMSLGARRDFLIRHKPTPAKHESETKPTKFDLHSGDLILMRGKFQSHWLHSIPKRKGGEADKGRINITFRKAMIKSGTDNYYRYNVGDGEVYKWSETSRTMVAWKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0L3"/>
    <dbReference type="STRING" id="336722.F9X0L3"/>
    <dbReference type="GeneID" id="13398724"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90019"/>
    <dbReference type="eggNOG" id="ENOG502S92A">
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    </dbReference>
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    <dbReference type="OMA" id="NSWALWQ"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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            <begin position="14"/>
            <end position="35"/>
        </location>
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        <location>
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            <end position="202"/>
        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="572" mass="61775" checksum="F01C77D1D973324D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84191"/>
    <dbReference type="HOGENOM" id="CLU_3070476_0_0_1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391188" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="53" mass="5630" checksum="9BE9BCD2FF2DC9A6" modified="2011-10-19" version="1">MKISTLLDSAFLACCACANPAPDPTAGTTAGKCVCLRLRMPTSEPRSRGIMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X145</accession>
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            <fullName evidence="9">Late endosomal/lysosomal adaptor and MAPK and MTOR activator-domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Schouten H.J."/>
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                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98544"/>
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    <dbReference type="HOGENOM" id="CLU_1836705_0_0_1"/>
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    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15530" checksum="E721F4A8724E90F9" modified="2011-10-19" version="1">MGAVCSSCLGQRHPSQDGDLDRILDSRQTSYGAIDSNDRHGHAQPDEEELQREREALEYITTDATEHMIDVLHPTDAAMEHSIDNGNDRHIRDDHSESESGQDAEEEAWLESIKSASNAQVKMPQNGTFVMNVGQLRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1N8</accession>
    <name>F9X1N8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_20893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856855.1">
        <property type="nucleotide sequence ID" value="XM_003856807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1N8"/>
    <dbReference type="STRING" id="336722.F9X1N8"/>
    <dbReference type="GeneID" id="13398414"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20893"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_1_4_1"/>
    <dbReference type="InParanoid" id="F9X1N8"/>
    <dbReference type="OMA" id="WDNVECI"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="667" mass="75467" checksum="306663D8AE1A4E0B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Y3</accession>
    <name>F9X1Y3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_25671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854700.1">
        <property type="nucleotide sequence ID" value="XM_003854652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Y3"/>
    <dbReference type="GeneID" id="13403756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25671"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="InParanoid" id="F9X1Y3"/>
    <dbReference type="OMA" id="NDYMALR"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="194"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="352" mass="39693" checksum="75AD006D67D646DA" modified="2011-10-19" version="1" fragment="single">AADQELRNRLAEACRHTMLRLERPWDSIRRYNYAVHDVAIAKTGHSMGLWAALVAESPNSVHGSQLAEKTGVELGLLMRLLRYATAQSMVEQTDVQSFRAIEATRTLSMPMMNSAFTVATEILIPSALSMDAYFKSTDFKEPADRGHTLFHQAFNTDQHCFEWLSAKPGLGQDFFNLMKVRRQGLKDWLDGFPVEKYLDVKDTTERMQFVDVGGGNGQQALAVLKRHPEIAGRVVVQETPTLGALEQLKSDPQGLIPMATDFFQPNPLKGAKAYYMRNIMHDWPDKECRVILGHLRDVLEDDSVILVDDLVVDDMEMHWHPSATDMTMMTLLAAKERSLTEWDALIESAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X244</accession>
    <name>F9X244_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_90520</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389964" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="103" mass="11481" checksum="88D300A2D6484B00" modified="2011-10-19" version="1">MKITFFSTLAMLSAAVLAAPVQQRDKVTSKDDYEGCDKRYHGNGAIWCPPTPQPPTTQIRSEEPKVPNAPNTVNAPRDILDDHNGNPTREIQLVVHAHRIRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X266</accession>
    <name>F9X266_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">DFDF domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">MYCGRDRAFT_99020</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X266"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.292"/>
    <dbReference type="eggNOG" id="KOG1073">
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    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
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    </dbReference>
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        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LSM14"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LSM14"/>
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    </dbReference>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
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            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="512"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <end position="201"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="573"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51513"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90671.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="61909" checksum="4A2760E8E1A88608" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2D3</accession>
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        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MYCGRDRAFT_68535</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855489.1">
        <property type="nucleotide sequence ID" value="XM_003855441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2D3"/>
    <dbReference type="FunCoup" id="F9X2D3">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2D3"/>
    <dbReference type="GeneID" id="13403429"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68535"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="F9X2D3"/>
    <dbReference type="OMA" id="EQMGEYC"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01582">
        <property type="entry name" value="Homoaconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="106"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="606"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP90465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="806" mass="86469" checksum="63F618E4B378D992" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2J6</accession>
    <name>F9X2J6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_37404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854725.1">
        <property type="nucleotide sequence ID" value="XM_003854677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2J6"/>
    <dbReference type="FunCoup" id="F9X2J6">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2J6"/>
    <dbReference type="GeneID" id="13403730"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37404"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_4_0_1"/>
    <dbReference type="InParanoid" id="F9X2J6"/>
    <dbReference type="OMA" id="VEPHCDY"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="33165" checksum="123F9E983ACDFE29" modified="2011-10-19" version="1" fragment="single">PISRYSKLPFRLLARQYGTDITYVPMMLAHEFIRSHIARDADFTTHPLERERTPDGREHAVIAQFASSDPIEFARAAEMIAPWVDGVDLNCGCPQSWAIKEGIGCSLMEKPELMAAIIRAAKDVLPPEKSVSCKIRVHKDLSKTIKLVQIVQQAGVDFITVHGRTRSQRSSTPPDYAAILSLRPHVTVPLIANGDAYTLSDVSKIASLTSADGVMAARGILENPAMFADHDVSPVECAKDFIEWAIRCPIPFPLVLHHVGEITARMPGMNKKEKKVLQECQDLMELVDFIDDRWGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2V7</accession>
    <name>F9X2V7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_22487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2V7"/>
    <dbReference type="STRING" id="336722.F9X2V7"/>
    <dbReference type="GeneID" id="13403498"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22487"/>
    <dbReference type="eggNOG" id="ENOG502T1XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024064_1_0_1"/>
    <dbReference type="InParanoid" id="F9X2V7"/>
    <dbReference type="OMA" id="KMHWSPR"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="494" mass="55271" checksum="7F804E6414131A6F" modified="2011-10-19" version="1" fragment="single">LPLNLIAAIISFLDDPADLARVTRTSRLLHYMTLPQLYHRVHLHSYSETRYVNGKPEGFGSGSPFMMALNGLATKSHAALVSELRLWGQWKELGIEDFAKGVIPNGTIMLGIILRAAIDKMVRLNSFSWELDSSPTKTLYLGLAARDTLTSLTLRFPSARVPRPFVLIPPMQNLRSFKALDIDPLCYPDDISLLLLHSRELRDLRLHFSPRMRSEAENSLALSTFFGKCVQANYKLKLKHFALCNFFGPNDSGGLGQILDEESLESLTMLDVWGGTDPRTVWVDESWKRIEKTPGPSLKRVRINEVSGAHIRLSSQSKLGVERMYLVNAKRPRTGYTPSASAGSSCTPGALTTPSPDTSSTPVDPDYEEVAICKEYLGSITQFHGHTLRHLLLRDIWALDEDDVAMLVRRCPNLEQLGVAIKDADQSILMRHMPFLTKLRALRILYNDSLVERMRTLSHEEIILGLEPALARPPIPVIEVIGLGDVIYKIGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2Y0</accession>
    <name>F9X2Y0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_219742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854939.1">
        <property type="nucleotide sequence ID" value="XM_003854891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Y0"/>
    <dbReference type="GeneID" id="13403486"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_219742"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9X2Y0"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP89915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="614" mass="65027" checksum="CD5DD856AF27A73A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X338</accession>
    <name>F9X338_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_68689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855050.1">
        <property type="nucleotide sequence ID" value="XM_003855002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X338"/>
    <dbReference type="GeneID" id="13399841"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68689"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.813"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="InParanoid" id="F9X338"/>
    <dbReference type="OMA" id="RFKLICW"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="606" mass="66119" checksum="67F4A88B92E63E5B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X355</accession>
    <name>F9X355_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_84837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855344.1">
        <property type="nucleotide sequence ID" value="XM_003855296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X355"/>
    <dbReference type="STRING" id="336722.F9X355"/>
    <dbReference type="GeneID" id="13400078"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84837"/>
    <dbReference type="eggNOG" id="ENOG502QVIJ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017834_0_0_1"/>
    <dbReference type="InParanoid" id="F9X355"/>
    <dbReference type="OMA" id="HWVEKTG"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="135"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="683" mass="75497" checksum="6FFC756150524504" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3W8</accession>
    <name>F9X3W8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_90984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3W8"/>
    <dbReference type="GeneID" id="13400958"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90984"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.864"/>
    <dbReference type="eggNOG" id="ENOG502RHRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698699_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3W8"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="395" mass="43768" checksum="E46B2F55627AE875" modified="2011-10-19" version="1">MNNQQYAQDFGFSLMEDSNERAGTAPPKVAATAAMRYGGMEMDVDNDSTTGAGAHTKQRTYYQAEKKFRCQADNCGRSFCSPHNVQQHNREAHTKEKPHACSICGENGKLKAFTRPASLYRHIRDIHKVDIEYERGKGVRKIVGPRMNPVHAAPVKPPRQGQPNGRQQNVYGAPQHDYPYYQQGRIEPVGHHIGTSGDLNQFQMPVQALHYQQDGMQAVEHGGGISDLPTQFQMPAQPSHTQQSGAQAVEQTNEMFGGRVQLEMPALSPVPNANMPMIYTCADGACGTFDNASDFLIHNHEVHDIARSAACACESCWAAFSRGNPDQTPQQQYPVVEDFMPQMPTDEALPIVQYQRLPDKATNSSEMDAVTAAEYVDRWMREDLCSSLPNSPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91009"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.894"/>
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    <dbReference type="InParanoid" id="F9X4L3"/>
    <dbReference type="OrthoDB" id="10598155at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="216" mass="22240" checksum="5AB16120B2283A6F" modified="2011-10-19" version="1">MSKKTEDSQQPWSISQYFLWTFGSILAGGLFITVAAISLTAIASGIGLLFTLAGAVFSAIVGAATLAAFALLSAAGLLATLTGNIILASASAIACPASQEPSTNPSVPSVPSVLACEPCAAKFFEPPETPVGFGAFQNCAVKTAWLLHPAGETSDVNFAVDKDNDVVVDYKMRFACPSITPDEALSAGIAKLVQGAHDDYRVSVWVAKALPDGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4P5</accession>
    <name>F9X4P5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_108236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Hane J.K."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
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        </location>
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            <end position="93"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
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        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90186.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="115" mass="12285" checksum="7814F79A76148F65" modified="2011-10-19" version="1">MPLLPADMVRDYVPAASTRRVKENETDPDTDAAKMESLRNCLVAMQSRAAKPIQCTPMKNRGGTSKSGGSGSRSLDAHGDALLFNTTPYPIGHPNSACIHGDMDRGYTGDPSCTM</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Crane C.F."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="258"/>
        </location>
    </feature>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EGP88974.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="698" mass="76657" checksum="FAC82C3DEABD21F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9X644</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Mycosphaerellales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="96" mass="10292" checksum="46AA68735753AB5D" modified="2011-10-19" version="1" fragment="single">QIRTTFPVARIKRIMQADEDIGKVAQVTPTVVSRALELFMIKLISAAAHEARGNSLGAGGGGAGKGQKRVLAQHLKRAVFADEKLDFLQEIVGKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R3</accession>
    <name>F9X7R3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853802.1">
        <property type="nucleotide sequence ID" value="XM_003853754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R3"/>
    <dbReference type="STRING" id="336722.F9X7R3"/>
    <dbReference type="GeneID" id="13404141"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91646"/>
    <dbReference type="eggNOG" id="ENOG502SK9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871511_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7R3"/>
    <dbReference type="OMA" id="RAYEPVF"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="291" mass="32699" checksum="5E7ACE82E92EFF3E" modified="2011-10-19" version="1">MAKPIPETHLLHPRDPSTSDGEWPEFELTNVFVSHPSSPSTPASLLTASVGHPLTVTGHLAPLDRNYAHLYLRSPLTKRTTIELTDVMTFSYGEDDAGYPVWAAGKAGWFRIRPGRAYRATFAEMERAVELWYFIADAYREERKVGKGKKAVALPDYTAEELFAKYAGEVLEDEGDVEGARERFVEHRAFVMSCMLAGKEGLEWKRLPLWEFMKRKFPEEFEELKARRNGKVEKGKKKRQDSMDTTSSTTSMVKRKTARAKSGLSNAVEVINLDDSDTVPGQATPAGIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R7</accession>
    <name>F9X7R7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_69755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854458.1">
        <property type="nucleotide sequence ID" value="XM_003854410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R7"/>
    <dbReference type="STRING" id="336722.F9X7R7"/>
    <dbReference type="GeneID" id="13395645"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69755"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7R7"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="22298" checksum="29F8B1CC4B29B1BF" modified="2011-10-19" version="1">MAAPARRLVRPTLFICDLQEKFRSAIYEFPKVVATTQKLLKASQVLDIPVFATTQLRGKLGETCPELGLDAEGGVKTKAHADKSAFSMWIPEVQKAFKELGPEKREVVIVGIESHICVTQTTLDLLREGHKVYVLADGVSSCNREEIPIALARLRAEGAVVTSSESFLYECMGDAGLAEFKAIAGIVKENSGKTKENLQALCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7V6</accession>
    <name>F9X7V6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_70166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854312.1">
        <property type="nucleotide sequence ID" value="XM_003854264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7V6"/>
    <dbReference type="STRING" id="336722.F9X7V6"/>
    <dbReference type="GeneID" id="13395498"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
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    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="350" mass="39027" checksum="C65FFBA39B967098" modified="2011-10-19" version="1">MVATITKYKAAAVNAEPGWLNLELSVQKTIHWINEAGKAGCKLVAFPELWIPGYPYWMWKVTYQESLPLLKKYRENSLASDSPEMHRIRAAAKENSIFVSLGYSELDLNSLYTTQVFIDPQGNVINHRRKIRATHVERLVFGDGTGDTTSMVVDTEIGRIGQLNCWENMNPFLKSYAVSLGEQVHVAAWPLYPHASTLTYPDPYTNISDANADIVTPAYAIETGSYTLAPFQTISAEGVKLQTPPGKEPEDHHVYNGNTRIYGPDGQRLIEKPTEDFEGLVFVDIDLNEAQLSKALNDFGGHYMRPDLIRLVVDTDPKSSVSKINGSGKHEIVSTMERVGLNKPLQSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7Z6</accession>
    <name>F9X7Z6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_108762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853986.1">
        <property type="nucleotide sequence ID" value="XM_003853938.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9X7Z6">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7Z6"/>
    <dbReference type="GeneID" id="13404325"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108762"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.819"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7Z6"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="41568" checksum="F3EB42EE3C3053B0" modified="2011-10-19" version="1">MLDGLLMLLLLSVIMGGASFLAGIVPLTLSLSSKKLRLITALGTGILVGTSLIVIIPEGVETLYKSSEASHEHNRRTVYLRSGSMSDAANGDVPHPAAISSTLTPIDPSSGHLSTHSRSAASAGDLQAGQAGQDAYREPHAWVGVSLILGFILMYLIDTLPQSASASSQPQSFPVSLNQFSFNLTSGASQHPTTPPAEISQSQATASRHIDGSRPSSTTIGLVIHAAADGIALGASSTSSSKKLSLIIFLALMVHKAPAAFGLTSVLLKQGLSVRTARLHLTIFSLAAPVGALLTWLAVRLLGATNSGLGNSASSEFATGVLLLFSGGTFLYVAMHTMQAAGATEHAHGQGHDMSDYAGVPMDDPYSSHAPPATRPHGSVLLDTVVTVGGMLLPLLTQVGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X868</accession>
    <name>F9X868_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_92288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853575.1">
        <property type="nucleotide sequence ID" value="XM_003853527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X868"/>
    <dbReference type="GeneID" id="13400847"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92288"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.90"/>
    <dbReference type="eggNOG" id="KOG1721">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X895</accession>
    <name>F9X895_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="364" mass="41032" checksum="B1201E40FD9435A7" modified="2011-10-19" version="1">MLQFIQDYFGLQQGPYDETPPDVPPRILVTVITSSDVMSKSEPASFSITLQAVVDGDRPVTVDVFHTILWRSFPTKHYEGFTFTDSRTQMKAPLPVRDIQYHVSGHLEASNECVAEIPTKVSGDRPYEVSFTTGNNDAMQTGHEYQIGLGPKDEISWWMMGSKAQVSAAPNERRGRHLDEDVPKLRMVLVNKATFKVPFSIKLRLLVQSVIPVTVSTYGTAIHSTVGALLGQGLTFTDILTGTQSRSSITHAPSSQPNWLDIFDPSIREIPINGMYSTPYEVDFTVYHADSSKNTEHPLTGLNTGHEHQVELDPKMAFFDWWKMGSKREVFAAPNRRREWREPGGYRPRLQMKIVNCARFLVDD</sequence>
</entry>
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    <accession>F9X8F2</accession>
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        <recommendedName>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502S4KZ">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390217" description="DUF7732 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="4">
        <location>
            <begin position="116"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP88375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="207" mass="20429" checksum="8F9617398C29E604" modified="2011-10-19" version="1" fragment="single">MKLPQTILFLLTLFTTIHALALPALLTSNPSAATELFKRKGGGGGGGRGGGGSSSGGRSGGSSSSSSSSSSSSGGKSGSGSGSSGASTRTAPTSNIGGSTRAGSGTPRAFGAGRGYYGGGAAVPYQAGSRSPTRSVAPFLIGGVALGAVAIFPALALYGAYAYNFGGPYRYYNQTSRTNESLPMDCYCGRLSTCGCDANNNTDWLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8N9</accession>
    <name>F9X8N9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_104314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853145.1">
        <property type="nucleotide sequence ID" value="XM_003853097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8N9"/>
    <dbReference type="GeneID" id="13399748"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104314"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.794"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="F9X8N9"/>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="362" mass="38443" checksum="075BC70989F7356B" modified="2011-10-19" version="1">MSAPDSSPQQIRTVTTDLLKINHPIMLAGMNVAAGPKLAAAVSNAGGIGVIGGVGYTPDMLREQIAELKGYLKDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLGELTEIIIDSGARLFVSAVGVPPKQVVDRLHEAGILYMNMIGHPKHVKKCLELGVDMICAQGGEGGGHTGDVPTTVLIPAVAELCKGHKSPMTGQPVQVIAAGGIFDGRGLAAALALGASAVWVGTRFILAEEAGAPRAHQEAVRTAGFDDNVRTIIFTGRPLRVRNNPYIANWEENRQQEIKDLTSKGHIPVEWDMERMGDDVDDDTMDNARPFLMGKAAAVVNHKKSAKVIIDEMVQGAVDTFHANSSTLSGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8R5</accession>
    <name>F9X8R5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_92316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852850.1">
        <property type="nucleotide sequence ID" value="XM_003852802.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8R5"/>
    <dbReference type="GeneID" id="13400679"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92316"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000454_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8R5"/>
    <dbReference type="OMA" id="PEWANSP"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1715"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1900"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1928"/>
            <end position="1942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1976" mass="217284" checksum="15244A6A248AD551" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8Y0</accession>
    <name>F9X8Y0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">MYCGRDRAFT_104112</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853475.1">
        <property type="nucleotide sequence ID" value="XM_003853427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8Y0"/>
    <dbReference type="STRING" id="336722.F9X8Y0"/>
    <dbReference type="GeneID" id="13397261"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104112"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.312"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8Y0"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="31">
        <location>
            <begin position="66"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="30">
        <location>
            <begin position="181"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="29">
        <location>
            <begin position="288"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="EGP88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="443" mass="47909" checksum="DD0B13C68B1EC020" modified="2011-10-19" version="1">MASVTRTLRPLARAAASTVSRTTLSRAALVRSTPATSRCLTSTPQRRNATPMDLDALQPTPIFHLSETEAAMAETVNKFANDVILPKVREMDEAEKMDPAIVEQLFEQGLMGVEIPEKYGGAGMNFTSAIVGIEELARVDPSVSVLCDVHNTLVNTAIIKWASEDLKKKWLPALATNTVGSFCLSEPASGSDAFAMKTKAEKTADGYTINGSKMWITNSMEAGFFIVFANLDPSKGYKGVTAFVVDKANPGLTIAKKEKKLGIKASSTCVINFDDCKVAKGDLLGKEGDGYKYAIGLLNEGRIGIAAQMTGLALGAFENAAKYVWNDRKQFGQLVGEFQGMQHQLAQAWVDIQGARALVYNAARKKEAGQDFVMDAAMAKLQASNVAGRVSGQAIEWMGGMGFVREGLAEKYWRDSKIGQIYEGTSNIQLTTIAKLLQKQYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9G5</accession>
    <name>F9X9G5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_104068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852898.1">
        <property type="nucleotide sequence ID" value="XM_003852850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9G5"/>
    <dbReference type="STRING" id="336722.F9X9G5"/>
    <dbReference type="GeneID" id="13397219"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104068"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.221"/>
    <dbReference type="eggNOG" id="KOG3454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079697_2_0_1"/>
    <dbReference type="InParanoid" id="F9X9G5"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="20656" checksum="528ACB78BA433C30" modified="2011-10-19" version="1">MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQAVIDGITSSYAAEGQSVPIAPGMNFGAPGQGPPGFGPPNGMPPGFPPMPGAMPPGMPPMPPGFPGLMPGGRGMPPLPPGFNPPPGGFPAGFNPPPGMPAFPPGGGPGPAGSPPGNMPFAPPGFPPNMPPGFSMPGGPSPGPGGHQPPPMRYGGPPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9V7</accession>
    <name>F9X9V7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_70588</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852794.1">
        <property type="nucleotide sequence ID" value="XM_003852746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9V7"/>
    <dbReference type="FunCoup" id="F9X9V7">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9V7"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="GeneID" id="13400880"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70588"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.8"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="InParanoid" id="F9X9V7"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="205"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="482" mass="53572" checksum="67AFDB3360EF2B4B" modified="2011-10-19" version="1">MASRRLALNLQQGLRAQRAINAVRPNITRRALATPVSHASTTESTTLSNGFTIATEHSPFAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTQKRTQNQLELEIENMGGHLNAYTSRENTVYYAKSFNSDVPNTVDILSDILQNSKLEPQAIERERDVILREQEEVDKQLEEVVFDHLHATAFQGQALGRTILGPKENIQSISRDDLSNYIKTNYTADRMVLVGAGGVPHSQLVELAEKYFGNIPTFNKQQQANANVRGLETQKPDFVGSEVRIRDDTIPTAHIAIAVEGVSWKDDDYFTALVTQAIVGNWDRSMGNSPYLGSKLSTFVHDNKLANSFMSFSTSYSDTGLWGIYLVSDAATRLDDLVHFTLREWSRLSFSVSEAETERAKQQLKASILLSLDGTTSVAEDIGRQIITTGRRLDPEEVERVVGAITAADVMSFAQRKLWDRDVAISAVGQIEGLLDYNRIRNDMTRLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA66</accession>
    <name>F9XA66_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_85700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852987.1">
        <property type="nucleotide sequence ID" value="XM_003852939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA66"/>
    <dbReference type="FunCoup" id="F9XA66">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XA66"/>
    <dbReference type="GeneID" id="13400392"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85700"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="F9XA66"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="40583" checksum="321A3B2E7F31F9DE" modified="2011-10-19" version="1">MALLVDKHRPRTLDSLSYHPELSDRLRALAASGDFPHLLIYGPSGAGKKTRISATLRALYGPGVEKIKIDSRVFQTTSNRKLEFNIVSSNYHLEITPSDVGNYDRVVIQDLLKEVAQTQQVDAAAKQRFKVVLINEADHLTRDAQAALRRTMEKYSPNLRLILVANSTSNIIAPIRSRCLLVRVSAPSEEEICKVLAKVGKDERYQACETLEKRIARDSKRNLRRALLMFEAVHAQNETVNDKTSIPPPDWEALIEVIAKEIIEERSPARILQVRAKLYDLLTHCIPATTILKTLTFKLMPKLDDTMKAEIIKWSAFYEHRIRMGSKVIFHLEAFVAKFMRIYEGSLLGMDLDDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAP3</accession>
    <name>F9XAP3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_104352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852059.1">
        <property type="nucleotide sequence ID" value="XM_003852011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAP3"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20458" checksum="905108F325FD7174" modified="2011-10-19" version="1">MFAAYRAFAIRRPLVAAGASTAVLFATGDAMAQHAVEGNFSKGKGHDFGRTARMALYGGAVFGPIATKWFGALQKKIVIPGKPNLEIIARVAADQTIFATCNLFVFLSSMAIMEGSDPQKKLESTYFKALQKNWMIWPLVQFVNFKYVPLGHRVLVVNIVSLGWNCYMSFLNSQGGEQYEVLPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAT0</accession>
    <name>F9XAT0_ZYMTI</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="component" value="Chromosome 5"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="845"/>
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        <location>
            <begin position="119"/>
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        </location>
    </feature>
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        <location>
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            <end position="23"/>
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    </feature>
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        <location>
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        <location>
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        </location>
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        </source>
    </evidence>
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    <sequence length="946" mass="107259" checksum="141EB1A4DF0154C3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IPO323</strain>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53581" checksum="02979FA10B84AB00" modified="2011-10-19" version="1">MPYINPQHSFASSSSSDAFDPPQHPLPSAARVVGHRPVLANGMVGRRLLPWPAPAPATPEPEPAAEPAAEPAAFEQPVHVDRGLIPYTIRQQIKALKRIAGWTFARIAAALDEPYTTVQRVANEAATPGRHLHSHLHGLRQFGTPVANRIIDYVTGSAEGRRATYQQIKEQLELVCSVDTIRRRLNERGYFKRVAKRAPFLDADGLDLRPQFGQWCIDQSNNGRTFQFGDSAAFGQGGQQKFLVIRRADEVFDPDCLGPKYRRQKTQLVFGFICGNKKSRLIFWNNQWGKMTAASLKEHVIPELHRFWRECGDAEAALRLQEQFDSGVESFESAFETIDGRFGSPTPVAEDAIVDDAVNGDVDISVTHDAMPMLMLDGASVHKAPAFRNELDRLEIPHSLDVWPANSPDLNPIENVWAIMKYRLNRFYPLPSTPEVHRQQIQEVWDSLTEHDIGRITGSFRSRCEKVIARKGRHTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC02</accession>
    <name>F9XC02_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_72053</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852173.1">
        <property type="nucleotide sequence ID" value="XM_003852125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC02"/>
    <dbReference type="FunCoup" id="F9XC02">
        <property type="interactions" value="989"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC02"/>
    <dbReference type="GeneID" id="13393949"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72053"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.331"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="InParanoid" id="F9XC02"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035175">
        <property type="term" value="F:histone H3S10 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051316">
        <property type="term" value="P:attachment of meiotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120110">
        <property type="term" value="P:interphase mitotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903380">
        <property type="term" value="P:positive regulation of mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905824">
        <property type="term" value="P:positive regulation of mitotic sister chromatid arm separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904967">
        <property type="term" value="P:regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="114"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="394" mass="44690" checksum="C13157550CE795FB" modified="2011-10-19" version="1">MADMQALEQRFESITVQDENQDSNAYQHKAKGSVSTVTSLSNLNAAAAPSRMKLPLQKLPANAAGKPSTSHSTITKITLPSQAAQRTSAESRPSDTDHISQAVAKPKNWNLTMFEIGKPLGKGKFGRVYLARERATGFVCALKVLHKSEITQGKVEKQVRREIEIQSNLAHPNILRLYGHFHDTKRIFLILEFAGQGELYKHLRKAQRFPEWQAAQYIAQMASALKYLHKKHVMHRDIKPENILVGMHGEIKISDFGWSVHAPNNRRKTMCGTLDYLPPEMIKPGREENWYTEAVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARGEMTIPPFVSNEARDLIKRLLVLDPEKRLSLEEVEVHPWIIKHCVKGERHYQRTSGDVKKEKASASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCG3</accession>
    <name>F9XCG3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852448.1">
        <property type="nucleotide sequence ID" value="XM_003852400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCG3"/>
    <dbReference type="GeneID" id="13396770"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93521"/>
    <dbReference type="eggNOG" id="ENOG502SKVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033933_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCG3"/>
    <dbReference type="OMA" id="MNYASWI"/>
    <dbReference type="OrthoDB" id="5309037at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64156" checksum="BAC3F380375725A3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCQ9</accession>
    <name>F9XCQ9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851373.1">
        <property type="nucleotide sequence ID" value="XM_003851325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCQ9"/>
    <dbReference type="GeneID" id="13393721"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28649"/>
    <dbReference type="eggNOG" id="ENOG502S689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082150_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCQ9"/>
    <dbReference type="OMA" id="YSYVAPY"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="18565" checksum="AFD4A197B9E2D98C" modified="2011-10-19" version="1" fragment="single">SVQPTATMPHATETLTNGDKTSSSSQFISHLTSLPAVNDGIETFKSNPYGKKSLEIVDGAYTRIGKPVEPYLQTPYSYAKPYVQKADELADSGLSWGEKQFPIVKEDTHTIVDTAKGYIFFPYSYLSKTWQDEYSKTAQHRGAGLSTTAFAIISTELRIASDVAQKIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD49</accession>
    <name>F9XD49_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_43945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851876.1">
        <property type="nucleotide sequence ID" value="XM_003851828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD49"/>
    <dbReference type="FunCoup" id="F9XD49">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD49"/>
    <dbReference type="GeneID" id="13393653"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43945"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD49"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0732">Signal</keyword>
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    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="579"/>
        </location>
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        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="579" mass="65117" checksum="486026D9232F33F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDB4</accession>
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            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">MYCGRDRAFT_109848</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP86463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502S7ZC">
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    </dbReference>
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    <dbReference type="OMA" id="RTACPFA"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="765" mass="82585" checksum="755551CC0B669BBA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDD0</accession>
    <name>F9XDD0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_109857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851798.1"/>
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    <dbReference type="FunCoup" id="F9XDD0">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XDD0"/>
    <dbReference type="GeneID" id="13401555"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109857"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.343"/>
    <dbReference type="eggNOG" id="KOG1061">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="InParanoid" id="F9XDD0"/>
    <dbReference type="OMA" id="NPPEVQW"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="737" mass="80188" checksum="05061EAA76FFF51A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDP7</accession>
    <name>F9XDP7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_73287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851555.1">
        <property type="nucleotide sequence ID" value="XM_003851507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDP7"/>
    <dbReference type="STRING" id="336722.F9XDP7"/>
    <dbReference type="GeneID" id="13402152"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73287"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.470"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_27_3_1"/>
    <dbReference type="InParanoid" id="F9XDP7"/>
    <dbReference type="OMA" id="EVENDPM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="2"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="749" mass="82801" checksum="A42A6CD830160744" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE27</accession>
    <name>F9XE27_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_44411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851325.1">
        <property type="nucleotide sequence ID" value="XM_003851277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE27"/>
    <dbReference type="GeneID" id="13393783"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44411"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_25_1"/>
    <dbReference type="InParanoid" id="F9XE27"/>
    <dbReference type="OMA" id="DICHATF"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="54" mass="6623" checksum="1C2E5B030688F1E8" modified="2011-10-19" version="1" fragment="single">MANSPKEFICQLCHRTYERVDHLNRHLDGHRNERSFKCSKCPRSFNRRDLLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE74</accession>
    <name>F9XE74_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_44455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851724.1">
        <property type="nucleotide sequence ID" value="XM_003851676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE74"/>
    <dbReference type="FunCoup" id="F9XE74">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XE74"/>
    <dbReference type="GeneID" id="13401840"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44455"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.619"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="InParanoid" id="F9XE74"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11077" checksum="30B5BC46EC064B07" modified="2011-10-19" version="1">MSARTDAEAEQNQITSGVTPDTLTSSLKEKLEATHVEIMDLSGGCGQMYEAIIVSPQFAKKTTLARHRLVNAALKQEIAAIHAWTPKCHTPEEWEKKKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE81</accession>
    <name>F9XE81_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_43207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851719.1">
        <property type="nucleotide sequence ID" value="XM_003851671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE81"/>
    <dbReference type="STRING" id="336722.F9XE81"/>
    <dbReference type="GeneID" id="13401842"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43207"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE81"/>
    <dbReference type="OMA" id="IREYYVT"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="161" mass="18363" checksum="C676CBD45D664F5C" modified="2011-10-19" version="1">MSSKPSRKRVAAFEDPDSDTNNQQTKKSKKTSGFSTEMQTDADGNPFWEISNKRRLGVSTFKNNVMVSIREFYEKDGQMLPGKKGVTLTTEQFNAVIELLPQIEPVLKEKGVDVVRPEYDQDEAEFEEVVKPVETKKVNRLDKYKNKNKKNHESTSEEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEA6</accession>
    <name>F9XEA6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_104997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851642.1">
        <property type="nucleotide sequence ID" value="XM_003851594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEA6"/>
    <dbReference type="GeneID" id="13401853"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104997"/>
    <dbReference type="HOGENOM" id="CLU_1604050_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEA6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="166" mass="18327" checksum="BAD01406DA9DED7A" modified="2011-10-19" version="1">MEILPDRKHFPSIIQATSQTNSAQASHYGGSPPSQSQSVSHASSSSAPSTREPVFTGGDPSATPCGTVSAGYGRDETPPTTTTIHQLSVVQPRSWLRPLRTTTLCQATSQRTRRWRGDCADFRLARMLRSSLHRLCVRPWFARRPMSCRRWKCNGASRGNRACRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEI9</accession>
    <name>F9XEI9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_86671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851691.1">
        <property type="nucleotide sequence ID" value="XM_003851643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEI9"/>
    <dbReference type="SMR" id="F9XEI9"/>
    <dbReference type="FunCoup" id="F9XEI9">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEI9"/>
    <dbReference type="GeneID" id="13401868"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86671"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="F9XEI9"/>
    <dbReference type="OMA" id="CFDNEIA"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="252"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="533"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="741" mass="81204" checksum="BF050A688409937C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF01</accession>
    <name>F9XF01_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_44786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851247.1">
        <property type="nucleotide sequence ID" value="XM_003851199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF01"/>
    <dbReference type="GeneID" id="13401079"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44786"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.151"/>
    <dbReference type="eggNOG" id="ENOG502R5K1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079904_1_2_1"/>
    <dbReference type="InParanoid" id="F9XF01"/>
    <dbReference type="OMA" id="HNINFFM"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="21959" checksum="488F77FF99984659" modified="2011-10-19" version="1">MESTHALEDGTIQLDPKTGTAFKLNKGQRLTVIDVEGVQVADLLAFSQADSREVISGGRTLDYASRLFLTTGDPIYSNRSNIMLNIVEDTCKRHDFLLTPCSKDTFRIIYGDKDPAPGCFGNLANALKKFGIDEDQIPTAFNCFMNVVVDGTTGELKVDPPTSKAGDHIAFTAEMDVIIGLTACSALQSNGGSFKPIQYRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF10</accession>
    <name>F9XF10_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_86766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851243.1">
        <property type="nucleotide sequence ID" value="XM_003851195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF10"/>
    <dbReference type="STRING" id="336722.F9XF10"/>
    <dbReference type="GeneID" id="13395354"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86766"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.161"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="InParanoid" id="F9XF10"/>
    <dbReference type="OMA" id="RDIHGWP"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="357" mass="38109" checksum="11E134FA8EFA08DA" modified="2011-10-19" version="1">MDRLKADYPWTLSPLISLAPMRLIALSHLATETSRAGGLGFIGAGSSISSPSLPHLLSEARSQIASSPNLRSVPDVLPIGVGFLLWAGDELLQGALPLLEEFKPAAVWLFAPHEVSDFETWTREVRRVTGGKSKVWIQIGTVEEAVEVTRSCQPDVLVVQGQDAGGHGLEKAAGLIALFPEVDDEVTRLCEAEGLTKPVLVASGGIMDGRGVAAAIALGAAGVTLGTRYLAAPEANLPKGYRDAVVKAKDGGVTTKRTKLYDQLRGTRDWPARYGGRGVLNYSWEDAEKGMSEEENQRLYDEALKKGDEGWGENARLATYAGAGVGLIKGLKSAARITEEVREDARKVLKTVGNIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF32</accession>
    <name>F9XF32_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_81468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850637.1">
        <property type="nucleotide sequence ID" value="XM_003850589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF32"/>
    <dbReference type="FunCoup" id="F9XF32">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XF32"/>
    <dbReference type="GeneID" id="13397970"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_81468"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.183"/>
    <dbReference type="eggNOG" id="KOG1775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_6_0_1"/>
    <dbReference type="InParanoid" id="F9XF32"/>
    <dbReference type="OMA" id="NNICTLI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="81" mass="8905" checksum="48D4DEE8B88BC3B2" modified="2011-10-19" version="1">MSSQLLPLELIDRCVGSPIWVIMKGDKEFSGTLLGFDDFVNMVLEDVTEYDYSGAQTKLPKILLNGNNVAMLIPGGMPDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFU1</accession>
    <name>F9XFU1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_44947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851150.1">
        <property type="nucleotide sequence ID" value="XM_003851102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFU1"/>
    <dbReference type="FunCoup" id="F9XFU1">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFU1"/>
    <dbReference type="GeneID" id="13397450"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44947"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_2_1"/>
    <dbReference type="InParanoid" id="F9XFU1"/>
    <dbReference type="OMA" id="QLHAAMM"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="198" mass="21949" checksum="19CD26DFEA3C6984" modified="2011-10-19" version="1">MSFTPNQTLTATRTLRYPAAVVYEIISDVDSYHKFLPFCQGSEVTKKSQPAADGKTYPEEAKLMIGFNGNINEEFTSRIYCIPGRVVEAVSGNTNGTLPKDEVSHHNERPSADQDPSRKATVMSQLLTRWTNHDETNPVPGQEKTEVNLTIEYQFANPLYAAMSSAVAPKVADKMIEAFENRVKAVLEGPAHAKRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG20</accession>
    <name>F9XG20_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851101.1">
        <property type="nucleotide sequence ID" value="XM_003851053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG20"/>
    <dbReference type="FunCoup" id="F9XG20">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="GeneID" id="13397480"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45389"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.437"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="F9XG20"/>
    <dbReference type="OMA" id="WEYTEME"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33754" checksum="96DD31E9CCBE7CD7" modified="2011-10-19" version="1">MPSHKTFSTDDIPDFSGKVIIVTGGNAGLGYESCLQFALHGSPRIFMGARSREKAEAAIASIKVQAPTADITHLPMDLSDLSSVKQAAETFLATSTRLDILMNNAGIMGCPPALTKDGFEVQLGTNHVGHALLTKLLLPILQKTAQSAEDGGKPSDVRIVNVSSAAHLMAPKQGLVLEAALTPMSDYQCMVRYGQSKLANIYFTQELAKRYPSIRSISLHPGVVKTNLLQSGIKESYSWVPEVVWSLVARLTSVSRANGTLNQLWASCSKDAKSGEYYDPVGKVGKKAAVVKDESKAAMLWGWTEEQLSKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG62</accession>
    <name>F9XG62_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_110040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110040"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.3"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="3">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="363" mass="40509" checksum="00C29578AF612492" modified="2011-10-19" version="1">MNFNPSRRLEKSISDHDINTHTHIAVMVTRSLLRRPLSAIASSAWTCPSCTTRAASILPSHSSRTPSILQRSQPQRRSLHHRPPLPYDDVFTREGVPGLFTSGGYDIVWRQYQSMLASKLNELVAGEPIENDDARTLVLKFARDPENASVFNHASMMHNNHFFFRNLSSAPLPLAKAPLIQGTLEKEFGSIDTLKVTFLDTAAAMFGPGFVWLVWAREPTRSREGAWRILTTYNAGTPYPEAGFRQQGVDMNNQNKESFANYLDGGQLLRPTNSAGAFGAHSSTGRELAKMPPGGTTVMPVLCVSTWEHAYMYDFGVRGKREYLENWWNVIDWGSVEALAPKSALGANLGFHGSRAQTRWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850489.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XHV2"/>
    <dbReference type="GeneID" id="13395190"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74353"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.38"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHV2"/>
    <dbReference type="OMA" id="SHKSEKH"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <end position="58"/>
        </location>
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        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="225"/>
            <end position="259"/>
        </location>
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            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31226" checksum="3946055002EAE87A" modified="2011-10-19" version="1">MAQTAPAQNSPTSVPKRPRGILKNSASFQQTSPETRTSPPPVTSAAQANDAPSDTTNRPVMPSRELSEKEITLMNTEMNAGPHRRTSSNPRGSLSRRQSSQSRGDEMAVDNESDGQRLKWDEANLYLNEGQMGGKMKIDEPKTPFAKNYDPAEDEEEISTINAQELAVDELEMNKPQRKGSGSRARESEIPGLDLGEPEMEALTQEESDGERRVHVNSDFANENGGRHGEENTSELSHEEQEKHKKFEEMRKKHYEMKNIKSLLGHPEELDALDDEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI85</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="7">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI85"/>
    <dbReference type="FunCoup" id="F9XI85">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XI85"/>
    <dbReference type="GeneID" id="13394832"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87220"/>
    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_1_1"/>
    <dbReference type="InParanoid" id="F9XI85"/>
    <dbReference type="OMA" id="RWEMYRA"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30637" checksum="91B17C8E08B58550" modified="2011-10-19" version="1">MLLLGLTGSIATGKSTVSNILSSPPYNLPIVDADKVARQVVEPGTFGYQKILDTFGPSTPDLLVPATPENGGEKGHNGKGRPLNRPALGRRVFGEGKDEDRKALNGIVHPAIRGEMYKQMLFAYLRGSWAVVLDVPLLFESGWEPLCGTILVVAVKDPKVQMERLRARDEHLTEEDAKNRVAAQWDVRDKAERCLRRGDKAGVVVWNDGGKEDLKRQIDQVMSQVRTSSPQWWAWMLLLCPPLAVLSGGWSYVRSWWIKKQWEKEKQREKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIH1</accession>
    <name>F9XIH1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_46430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850482.1">
        <property type="nucleotide sequence ID" value="XM_003850434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIH1"/>
    <dbReference type="GeneID" id="13402732"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46430"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="InParanoid" id="F9XIH1"/>
    <dbReference type="OMA" id="IFNAFYL"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="566" mass="62244" checksum="51AD18D41C308C83" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIH7</accession>
    <name>F9XIH7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_46388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850310.1">
        <property type="nucleotide sequence ID" value="XM_003850262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIH7"/>
    <dbReference type="FunCoup" id="F9XIH7">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIH7"/>
    <dbReference type="GeneID" id="13394738"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46388"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_2_2_1"/>
    <dbReference type="InParanoid" id="F9XIH7"/>
    <dbReference type="OMA" id="FCEHHFL"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="224" mass="25059" checksum="6A1B61C6B229BD6E" modified="2011-10-19" version="1">MSPFITSAPAVDFDGLSWPSTGTLARLHEKENPAEAEARLQKLSGAVRTILECIGEDPDREGLHGTPERYAKAMMFFTKGYEENLRDIVNGAVFHEDHDELVIVKDIEVYSLCEHHLVPFTGKMHIGYIPSQRVIGLSKLARIAEMFSRRLQVQERLTKQVALALSEVLKPQGVAVVMESTHMCMVMRGVQKAGSVTTTSCMLGAMRKRAKTREEFLSLLGRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ04</accession>
    <name>F9XJ04_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849292.1">
        <property type="nucleotide sequence ID" value="XM_003849244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ04"/>
    <dbReference type="GeneID" id="13398913"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95535"/>
    <dbReference type="eggNOG" id="ENOG502R4VC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1031369_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ04"/>
    <dbReference type="OrthoDB" id="3645087at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30983" checksum="AC79B0EFCDB81178" modified="2011-10-19" version="1">MAPRKRQSEGEHEGNAPAKRPRQRKGGVDFDTAATQDNSPLLQLPAELRNRIFEMVFEDMTITWPRINTTKGAVNKPQGPALLFTCKQVSAEALKIFYANATFAFGAPKRLPSWQKKIPQGLQRLVLFKVVFVMTGNSDKEFQDAKDLGMDSEFLDMTVLHWKMGSAEIPCYVYRLEYGDHKQQQRWTPVWPEVVLHSYIVGDGATLRSNKKILEEANKKTPYEPKTDRLRRVDWNRPPHSIFQLWSLYPNGRKISPLLNSLEMRTGPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJN1</accession>
    <name>F9XJN1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_110841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849634.1">
        <property type="nucleotide sequence ID" value="XM_003849586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJN1"/>
    <dbReference type="GeneID" id="13402281"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110841"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.471"/>
    <dbReference type="eggNOG" id="ENOG502R8DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1503397_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJN1"/>
    <dbReference type="OMA" id="RIDLNVW"/>
    <dbReference type="OrthoDB" id="3636523at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="207" mass="24262" checksum="94FE36FFB1EDA62C" modified="2011-10-19" version="1">MTVSSYDLPTEIWLSILRHVDSQSLFRTVRLVDRRSRSCADDIFRNEILPDFQISLNVLLESEYPLRPGGDVQLVFGFRQVTQWEDDGTEVAQYTVIRSDPEVRKQRALARWKGRAEPVAARDPLMLRVTLPPQFLVNMQGRAWQDCVCPSSDTTTGRYDKLDWKERDELLQLDWRKFMATYLRKTSALEKIADQRRQTIGSRFPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK02</accession>
    <name>F9XK02_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_75517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849384.1">
        <property type="nucleotide sequence ID" value="XM_003849336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK02"/>
    <dbReference type="STRING" id="336722.F9XK02"/>
    <dbReference type="GeneID" id="13399080"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75517"/>
    <dbReference type="eggNOG" id="ENOG502SIPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_1"/>
    <dbReference type="InParanoid" id="F9XK02"/>
    <dbReference type="OMA" id="SGHAWGM"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="31516" checksum="B978E29A1DCCC2BB" modified="2011-10-19" version="1">MGTTTLHIQKSKTQSDRSQLLHCGNLEADQGWFTRGGGTSTASNPKPESQRRKVVIICVLIEHPTEGLILFETGGGENYPEVWGAPLNDIFARVDYQTDHELPTQIAKTGHSIKDVKAVIMGHLHLDHAGGLEHFKGTDVPIYVHEKELKHAFHSVATKSDIGVYLPKDLGFDLNWKSFYGDFLELAPGINLRHSPGHTPGLCIMQVNLKESGTWIFTTDQYHVAENYESGVPQGWLARDHDDWIRSHQMITSLQKRTNGKLVFGHCGDTLAKYQIAPHTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK84</accession>
    <name>F9XK84_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_95719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849712.1">
        <property type="nucleotide sequence ID" value="XM_003849664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK84"/>
    <dbReference type="GeneID" id="13399090"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95719"/>
    <dbReference type="HOGENOM" id="CLU_724038_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK84"/>
    <dbReference type="OrthoDB" id="5232355at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395546" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="382" mass="41819" checksum="52713454DE548E2D" modified="2011-10-19" version="1">MLFHTLLAAGLPLTTALTHAALDSQPAAAELSLDKRQSICGVSGYDDDNHKPFEVILKKAWNAEQCSAYCKSRARCQSFAIGNDECKLYCEPVSGTYKSGRSQYKFYGRDCPYSPSKQLVSHKSVNHCYNSHYEPLRVLVRQPLRVLVRQPPRQPPREPSRRQPPRRQPPRQPPRQPLRVLLIDASTSSIWSKNSGTTIDAVKTQDSLPATEIAITCEFLPETANTLSCEDPTNTAVNKLGFCASLDNSLALADGGADCTFYNYRAVCETSPFTPPFLISATDPATGSFLGYITAAYFSFGIRDLTTTASEALQVTYDPSSGETGHPSQLTITSLNSADYQDLTLLSILAFVQTSEDNPPQDMRSGSNKYVSGCSNNTTTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKF4</accession>
    <name>F9XKF4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_75924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849570.1">
        <property type="nucleotide sequence ID" value="XM_003849522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKF4"/>
    <dbReference type="GeneID" id="13402367"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75924"/>
    <dbReference type="eggNOG" id="ENOG502SMXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040076_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKF4"/>
    <dbReference type="OMA" id="GPMFADD"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="244"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="395" mass="43862" checksum="EAFF709F9B5FB65D" modified="2011-10-19" version="1">MRGHTHTHTRLHSKPYFDLDVGLANSAHSRNTSSSSTTTSSSVFQQLSSSIPVTTSLSFTTPLKIAPTPEPTRVQLQRQRLQEQHARTPVSKARTIPAFKTSAAFFASLRTNLRLHASPPPSPLSTPPSMRGSTTSLPPPSPLSFPALSMDDHDPTSDDHDDHHHPPHDPLDGVPELTSYLTTDDAERTEGLKLVADSVAQQRQLANQTLLYNPANLAVMIAILSFAGRYVWRRYHHDYYILGMTVIGLIMAGMAGARFATQGYLFAAEEINWDWVGDSDVLVTKFGEEVIAAVVIEWVSGESRQKRKKAWRGLIRAWTVRLKYRGKGVGSALLEEAVAEAKRKGAEGLEFAEDHANSRRVLPAFYNGYFDRQDRNARELLENLMQSSPGRGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKL5</accession>
    <name>F9XKL5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848750.1">
        <property type="nucleotide sequence ID" value="XM_003848702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKL5"/>
    <dbReference type="GeneID" id="13398783"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96022"/>
    <dbReference type="eggNOG" id="ENOG502TN7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588227_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKL5"/>
    <dbReference type="OrthoDB" id="3440338at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="465" mass="51815" checksum="13670629FC3D7BE1" modified="2011-10-19" version="1">MRQAMESSWDEIGPDEATGAGSDHDEREVSDSQDDEPGYCTLNLSIPKNHTRTRKAEGIDLTEGLGTNNDDQVSVSDECADDSDPEEQDETGLDPLQSKHIDPSTQPGTQIVADSDEDNDAEEDAIAVASDRGGLEAMRSMYRALYEEEGLVAMAMKAMNRYSEDSNTLTDTAELARTTAWHVMMTTHPDVLQSLLKGTLLADAKDDEDLRRILDTMSIRACDVRFPQPAIYQNIFANELLQCADAMEEYCDQDGDHTRARQVDSFRKPLPKLASGPYRKRKYLTPQTSKSISDARKSHVTTFLAGLRKRIEEVDINERDLPLKCPLVEIGYTQDTEVRLKAHLNHTNSNYIMNLMDAVANMLWPDRFKIHQTKQRLRKKSFVVGLGAVLGLEPQTCRCTEISRVEGAKWEANARRKKEQANKAAQAIGAKIKSIREKVAYLGLLEGALKAFTETIQSVAGGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL09</accession>
    <name>F9XL09_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_110944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848772.1">
        <property type="nucleotide sequence ID" value="XM_003848724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL09"/>
    <dbReference type="STRING" id="336722.F9XL09"/>
    <dbReference type="GeneID" id="13398763"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110944"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="InParanoid" id="F9XL09"/>
    <dbReference type="OMA" id="TFPDPNF"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="573" mass="65362" checksum="5CC2246D1D60DBF0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL20</accession>
    <name>F9XL20_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_105867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849211.1">
        <property type="nucleotide sequence ID" value="XM_003849163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL20"/>
    <dbReference type="GeneID" id="13398758"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105867"/>
    <dbReference type="HOGENOM" id="CLU_2098761_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL20"/>
    <dbReference type="OrthoDB" id="10347287at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390781" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12806" checksum="A0BA439858E400C3" modified="2011-10-19" version="1">MQFTTSLLMATAIFSAASVCARNTEAHWCSGTGESYAYWWTTCDNAYGGDLGEMQVGTDSYHVCCLDPAWVEAYRIICNRDGGKIQNGLNGLVKCNKQHRDPPPRKRFEGMSGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL22</accession>
    <name>F9XL22_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_87692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849209.1">
        <property type="nucleotide sequence ID" value="XM_003849161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL22"/>
    <dbReference type="STRING" id="336722.F9XL22"/>
    <dbReference type="GeneID" id="13398756"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87692"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="InParanoid" id="F9XL22"/>
    <dbReference type="OMA" id="VCYPAGY"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="51"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="30264" checksum="0121ED15E69B0ED8" modified="2011-10-19" version="1">MLTARAATTPDISSIERKDHTTTAPDGHTVNIAEFRSETTPASNKEPSPAIFYIHGGGMILGSVDMFTPGIKQRVHLTGIPVFAVTYRLAPEFPDPIPVTDCFSGLQWLSSHAAEVGVDPAKIIIMGESAGGGLAAGTALMARDQGLNPPLRKQILIYPMLDDTNIEPIAGIEPYATWNSGYNLTGWTALLGKARGTDEVSPYAAPARAKDLSGLPETYIDCGQLDIFVHEDVQFAARLMAAGVQTELHIYPGQIHGFNMYAPEAQYAKSATENVKRAILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLH5</accession>
    <name>F9XLH5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_48604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849088.1">
        <property type="nucleotide sequence ID" value="XM_003849040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLH5"/>
    <dbReference type="FunCoup" id="F9XLH5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLH5"/>
    <dbReference type="GeneID" id="13398163"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48604"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.370"/>
    <dbReference type="eggNOG" id="ENOG502QS3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044499_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLH5"/>
    <dbReference type="OMA" id="DDWPSKI"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="38201" checksum="638F6CDE2E92BE71" modified="2011-10-19" version="1">MFIFKHGGRQAAQVFRPASLHLNKRFASKIAIPFQPPPFPVIESCPAPTCQCRESPQGLDIDREVNLNGSMATYAQQLLICTDKDDWTSKIEDEEDAVLVRELKKNLTRGGKFVDPYHNIMITNSSFPPSERSPPPQSTSPTPPSSASAYLLPSFKYIPIIPTDPKGVEDFIRAYLLPLKLHPSYEKLSLEQKVHLLRQSELQNSFLGVRPVDDILVLICGHGGRDQRCGKMAPILRAEFEEKLRSQNVSVLDGTPGPERSNAPEDPPAARIASISHIGGHKFAGNVIVYIPPSFTRNPLAGKGIWYGRVGPEHVEGIVSETILGGRVIKENFRGGVDQDGNVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLN3</accession>
    <name>F9XLN3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848832.1">
        <property type="nucleotide sequence ID" value="XM_003848784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLN3"/>
    <dbReference type="STRING" id="336722.F9XLN3"/>
    <dbReference type="GeneID" id="13398632"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96164"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.204"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909748_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLN3"/>
    <dbReference type="OMA" id="AWIAHEV"/>
    <dbReference type="OrthoDB" id="10417085at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="34375" checksum="D2B26EF009A4FC3A" modified="2011-10-19" version="1">MNDDRYSRHGDGNYRQGYPPSVPASRAGGRHHDASQPYFEPPPIAGYDDGDYVPPREVHDHYGVDPYAQSGARPQTTEMAAYDDEIAEAGYRRGYEDTRAYTHLPPPPSDHELGRRPRRHRSVEGSSRYDDRSEYSDDDSYADSRSRDRGGRRRYSDEERTMDRRSRSRSEPRRGGREAFGGLSESEVGLGAKLVGGGAGALLGRKLGKKSALSTVAGAVVGSIAATAIEKQIEQRRGDQARGHRVRGDEERDGERTRPRSRSRSGFRERLRSLSRRGARSLSAGPRRTRRSDSFSSEESFRRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMY2</accession>
    <name>F9XMY2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotyrosine-specific protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MgPtp1</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_63621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848343.1">
        <property type="nucleotide sequence ID" value="XM_003848295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMY2"/>
    <dbReference type="FunCoup" id="F9XMY2">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMY2"/>
    <dbReference type="GeneID" id="13396135"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_63621"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.210"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_12_1"/>
    <dbReference type="InParanoid" id="F9XMY2"/>
    <dbReference type="OMA" id="WSIDKAP"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="253"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="354" mass="39588" checksum="65EB45FC1B090F58" modified="2011-10-19" version="1">MANNPPPLPAFLQQSKTDLHSKFVDLEWQQRNRLAQGTSHPANGSPDSSPFARLTGTHISSRNRYLNVEPFAANRVKLRVASASDNDYINASPISLGKRRYIATQGPKDTSVAHFYRMLLEESQNPAVVVMLTQTHESGKEKCFQYYPSSERDSPLHLPVKASEEEVVEQNGHEEAYNGTVELISVERHTPSRSEVRRMRLRFEDKPNQEREVRHLLFEGWPDFLVPEGDDRAALVELVRLSAALTTYSPANGSLASTLASASPSNPRIVHCSAGVGRSGTFIALDYLLSEMFEGNWDNLAIGRDPVAETVDELRKQRMMMVQGESQFMFLYEALREQWAKKGGGEDAKGGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMZ0</accession>
    <name>F9XMZ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_106110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848631.1">
        <property type="nucleotide sequence ID" value="XM_003848583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMZ0"/>
    <dbReference type="FunCoup" id="F9XMZ0">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMZ0"/>
    <dbReference type="GeneID" id="13396289"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106110"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.219"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMZ0"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="109" mass="12093" checksum="2B208C04BE67B985" modified="2011-10-19" version="1">MGLFSSSSSPSPPAPEPSNDGGFIAPDRTARAQCWEGRDNFFACLERNGIVDSVREDAKARAACAPELKEFEKVCASSWVTYFKKRRVMEHQRDATIKKLTAENAKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN39</accession>
    <name>F9XN39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_18448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848370.1">
        <property type="nucleotide sequence ID" value="XM_003848322.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN39"/>
    <dbReference type="GeneID" id="13396277"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18448"/>
    <dbReference type="HOGENOM" id="CLU_054430_0_1_1"/>
    <dbReference type="InParanoid" id="F9XN39"/>
    <dbReference type="OMA" id="EDFRKHQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19628" checksum="EA1FA9827D94914F" modified="2011-10-19" version="1" fragment="single">DTVPDRRMFVFRHLNENLLGFVQRDLSLKLIERILKCALQGLAALHEQDLVHNDTCIYAMTQRLVLAVDESELLEGEDKLAIVLERQLSYFADESGFKAFMQYIGAESAWHEIFRVINSGFGKDQPRKPFALWDGNGLDGDFKAFIGGLTNFDPAKRMTAQQALAHRWLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNH1</accession>
    <name>F9XNH1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_111432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848193.1">
        <property type="nucleotide sequence ID" value="XM_003848145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNH1"/>
    <dbReference type="FunCoup" id="F9XNH1">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNH1"/>
    <dbReference type="GeneID" id="13401774"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111432"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.120"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="InParanoid" id="F9XNH1"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP83169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="464" mass="51365" checksum="51BABCEA43D1A887" modified="2011-10-19" version="1">MSTIKPLATFTPACTARTWSSQPHPHLPILATACSDKTVRIYDLKSFTQQSVISGGHKRSVRAVAWKDTGKGESGGESVLATGSFDASAGIWKRWENAQRAAGKQQSNGDTDGDEIDFTGGLAGGNASDDEEDEWRLEVILDGHDSEIKSLAFCPTAPLLATCSRDKSVWIWEELDDGENFETMAVLQDHEGDVKCVAWHPTEQLLASGSYDDRVRLWREDSDDWACCALLSGHEGTVWFVEWEPTVNVGKVGSDKEDRERAGPRLLSCSDDTTIRVWRRRPREKKDGALGQGKVASIWKNSEFEEDWFEEDRLPKVHERPVYSVSWSAKSGLVVSTGSDGKIVVYREVEVSGKEDVEMSDDASPPSASSTKWVVVAEWENAHDVFEVNHAVWAPRVDKGKRFEDEEVIVTTGDDGEVKRKAGQSRHEGIVQSTKARTIETSARVRCAPRQLASELRGAAMRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP07</accession>
    <name>F9XP07_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848101.1">
        <property type="nucleotide sequence ID" value="XM_003848053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP07"/>
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        <location>
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            <end position="137"/>
        </location>
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            <end position="222"/>
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            <end position="278"/>
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        </source>
    </evidence>
    <sequence length="614" mass="67256" checksum="949AD9B5EB08EB8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
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                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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        </source>
    </evidence>
    <sequence length="491" mass="52547" checksum="557D07F9FC101169" modified="2011-10-19" version="1">MSSEGKVAVEEVSKHSTAEDCWVVVNGKVYDLTTFAPEHPGGAHVITKWAGKDGSEVYNTYHSATLIESTLEPSQKKGSLDPSTVTPEWTAAPSAPTSAQPKPSSIPPLTSIVSLPDLLTTFGQITTPKSWAYTSSASNDLLTHHANLATWSRLLFRPRILRSVRSISTSTTALGANLHMPVWICPMGIAKTAGPEGEAALGGGAADAGIVHCMACTTSSMSVSEMLDAVPKGWPYFAQVYINRDRAKTEAVLRELERTPQVKAIFITVDLAVVSKREADEKLTIAEALAEGGRPAGGLARSTGSFIDWEFSWKDFVWLRRHTSKPLVMKGVQSAADAVLAMEMGCKGIVVSNHGGRALDGAPSTVGVLLELRRDCPEVFERMEVLVDGGVRRGSDVVKAVLLGAKAVGVGRPFQAAVAWGREGVGYAAGILQDEIETAMRLCGITDLDAARGDLSYLNYTALLQDLPPKPATRGWFGWGGKDFGKRQMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ40</accession>
    <name>F9XQ40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mating-type protein MAT-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAT1-1</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_88443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mating type proteins are sequence specific DNA-binding proteins that act as master switches in fungal differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha-specific genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MATALPHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847598.1">
        <property type="nucleotide sequence ID" value="XM_003847550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ40"/>
    <dbReference type="STRING" id="336722.F9XQ40"/>
    <dbReference type="GeneID" id="13401352"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88443"/>
    <dbReference type="eggNOG" id="ENOG502S4ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940752_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ40"/>
    <dbReference type="OrthoDB" id="5398665at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="9">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="296" mass="33370" checksum="17FBB0B7DF582AE8" modified="2011-10-19" version="1">MPHLRIPLLPHFHHTQTIGATTVDMAAAVSAQEMALYLTGCTQEQRDQFNEMLQQINSQASSLNMGTTLVHSGVTKNTKRKGKLTKADLASIGPPKRPLNSWMAFRNFYIPLMLGVPQKCVSKTMTMLWSNDLFKAKWALLSKAYSVARGTRAKIDVPLSGFFALCAPLVGVIPPQDYLGMLGWQMTAPRPGETVSFVILNFVAFQTDLIPDAMPPPHLHPRFRSVLPAHQVHHTHRGRSRQDLLRRRLRRRGRRLLARHERSRFSHHGVQARHHRGRCPEGLQANSRPTGPQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ84</accession>
    <name>F9XQ84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847723.1">
        <property type="nucleotide sequence ID" value="XM_003847675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ84"/>
    <dbReference type="GeneID" id="13401023"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97444"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.263"/>
    <dbReference type="HOGENOM" id="CLU_1887379_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ84"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="14845" checksum="43541094282A5F0C" modified="2011-10-19" version="1">MISFAGHFLLEVCMKYRDQLSVNVDENLRRVSAALAIFARLPVLPQHSVSRVTSSLMRRLNECTASLGIEGLLTESPFANLNAFTSTSGHGNLEGGNTTTSVFELEMDNGSLPNDFLHADFSDMAFPNHNFDFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQI2</accession>
    <name>F9XQI2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_51545</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82649.1"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQV8</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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        </citation>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="23671" checksum="FF1C434D7389CE5F" modified="2011-10-19" version="1">MKQAQPRRRRPQGRAETVLHDLEALFERTLRVDTDILRAMLRDVEFKKDLDALSDPDLQPDEQDRYTQHRASWTAVVGECRQVSDSTAATGARLEAFCLDLETKLAFYHSNCFPGPLRQLVTLLSRVCHHPFRTRRDECYPDIVRASLAVSRVVKSLRALHKETHYETLSHRGERDPAIRFSILRTTTQLHKETHYETLSHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRC7</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51733"/>
    <dbReference type="HOGENOM" id="CLU_2549380_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRC7"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="83" mass="9398" checksum="24F57C3D48C3DD6C" modified="2011-10-19" version="1" fragment="single">CYFPGTAIFLGLLFSWDCHFPGTAIFLGLLSSWDCYFPGTAIFLGLPFSWDCYFPRTAIFLGLPFSWDCHLPRTAIFLGLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_97968</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRX5"/>
    <dbReference type="GeneID" id="13399207"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97968"/>
    <dbReference type="HOGENOM" id="CLU_1448801_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRX5"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="20575" checksum="A936605F0AB35F80" modified="2011-10-19" version="1">MVDANPGQDRNADGHTTRCSTGANTPSKDVYTPTGLAKHPVAYVSRGKLSETTFVGGVDFDQLTERVAEVERLADAARQAIQVVADAALRAINHRVATRKTVVDRMGATRDVQLGIQRMLNPGPSPADETRTDLQRESELYKAALERVLGGANENDPAVKMPRTRLEYAKLKLEQSLHQRHEMDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS07"/>
    <dbReference type="STRING" id="336722.F9XS07"/>
    <dbReference type="GeneID" id="13396699"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51788"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8141" checksum="ED8E36CCB464D7C8" modified="2011-10-19" version="1" fragment="single">AVAIHRGDSNVKGTVTFERTSGKAARAPSHETSLAIIPTPSAMIHAFGDNTNGCTGAGPHFNASYLAWCLRSKQRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXT4</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">MYCGRDRAFT_89089</name>
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    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857539.1">
        <property type="nucleotide sequence ID" value="XM_003857491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXT4"/>
    <dbReference type="STRING" id="336722.F9WXT4"/>
    <dbReference type="GeneID" id="13403110"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89089"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.593"/>
    <dbReference type="eggNOG" id="ENOG502S06P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071891_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXT4"/>
    <dbReference type="OMA" id="CQMNDGM"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="38197" checksum="95FD4E42D0C16AB2" modified="2011-10-19" version="1">MATSSRTWTEVGPHDKTDSSEDNADATSSSSLLYTLLPSLVQRRIPKLRSFKKALSDYDQRSRRTRTFSQTSVTSTSPPPSYRSNSQDRDSIDEQPGFLFRSGRRSEPPSRPSTSGTSTPTYLEETRSGVQWRYADPGFALLSLSSHEASTSTRSSHLIRRQYVDGVACVLRGLPSDLSLEEELSLREAFPPSLSPPSLAESSLTLRNPDITFRSQPDSAPSSLHRHVATLTFYLLLAISFITPYISHILQSAYAFDRKNHLSERAIAQSVVVADAVGRQAMSMAREVCGWNEGRVGEKMKEVGVYVVQGFSGGVYCGLGEGMVAMGKRRREDGMDWLGRDGAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">MYCGRDRAFT_107151</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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        <text evidence="1">Belongs to the arrestin family.</text>
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    <dbReference type="STRING" id="336722.F9WXY2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.881"/>
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    <dbReference type="InParanoid" id="F9WXY2"/>
    <dbReference type="OMA" id="NMVDTQE"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arrestin_C-like"/>
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    <dbReference type="InterPro" id="IPR050357">
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    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="411"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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    </feature>
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            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92386.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="828" mass="92371" checksum="E968B283516AFCD4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY02</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856252.1">
        <property type="nucleotide sequence ID" value="XM_003856204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY02"/>
    <dbReference type="GeneID" id="13394657"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102388"/>
    <dbReference type="HOGENOM" id="CLU_1284180_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY02"/>
    <dbReference type="OrthoDB" id="3644453at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="215" mass="23707" checksum="9AEAE483C266BEB0" modified="2011-10-19" version="1">MLIERLTRELSKTQENHRNEQRELAEKSEEVVELRKALTKALTPNLPRGGQPQPRARPTVSPFATPLGRRASSMQWSPQALPQSSKLPHEVRRADIWNTGSAGTRENLKFGVPGQIKHVVDQKDHDSPGTLESVATPSALNHASSHRVLHVDNFAKHHELLTRKSRSMADMRSRKGDGRETGPEQESAPGTPRSRLQAYVEADEGSGGEQRGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZA9</accession>
    <name>F9WZA9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_89593</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857487.1">
        <property type="nucleotide sequence ID" value="XM_003857439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZZ3"/>
    <dbReference type="STRING" id="336722.F9WZZ3"/>
    <dbReference type="GeneID" id="13403058"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102274"/>
    <dbReference type="eggNOG" id="ENOG502T00Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850043_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZZ3"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="139" mass="15388" checksum="CEB9B18674CBC137" modified="2011-10-19" version="1" fragment="single">MARRSSARLRERSTTPKRVSLSHDAITRTPRTMPAKLSSLQESDEMPGAFPSSVSPSENKLVLNPVIPKNLATPSKATPIKPSEQEMHPQLHHQSTAKPLDEARHLGFSNMGAHTEPPRQTNRLAMLQGTPTRARDLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0I2</accession>
    <name>F9X0I2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856572.1">
        <property type="nucleotide sequence ID" value="XM_003856524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0I2"/>
    <dbReference type="GeneID" id="13395357"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102767"/>
    <dbReference type="HOGENOM" id="CLU_2905887_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0I2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="6894" checksum="8A6C44A59E4EEC26" modified="2011-10-19" version="1">MSCSWCRRNSIKEDARLPRGHSRSSPRPSHRIPVPPTLPIVIPIVSLILLTSMVPLVPLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X138</accession>
    <name>F9X138_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_66280</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856344.1">
        <property type="nucleotide sequence ID" value="XM_003856296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X138"/>
    <dbReference type="FunCoup" id="F9X138">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X138"/>
    <dbReference type="GeneID" id="13402895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66280"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1073"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="InParanoid" id="F9X138"/>
    <dbReference type="OMA" id="QPWKENI"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="19">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP91320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="273" mass="30865" checksum="C2B54156C60130B2" modified="2011-10-19" version="1">MAEINGEMTLDQYEFPNNRLRRRIMSEDRTPLVLIACGSFSPITFLHLRMFEMAADYARFNTKFEVVGAYLSCVGDAYNKKGLVKAEHRINMCSLAVQQSSWIGVDPWEALHSEYLETAKVLDHFDYEINTVMGGVETPNGKKKCRIALLAGADLIQTMSTPGVWAAKDIDYILRNFGAFIVERSGTDIDEALAALQEWKDNIWVIQQLVQNDISSTKIRLFRRRDMSIRYLVPEQVVQYIEEHSLYDEDGVASTSSSKERRAGESSGVSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Q0</accession>
    <name>F9X1Q0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_34068</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856847.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Q0"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34068"/>
    <dbReference type="eggNOG" id="ENOG502SBH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196414_0_0_1"/>
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    <dbReference type="OMA" id="NTACEGD"/>
    <dbReference type="OrthoDB" id="8122555at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="6637" checksum="86EF1A0E246419EE" modified="2011-10-19" version="1" fragment="single">PQSTRGSSLAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNSPAGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Z0</accession>
    <name>F9X1Z0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
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    </protein>
    <gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Z0"/>
    <dbReference type="STRING" id="336722.F9X1Z0"/>
    <dbReference type="GeneID" id="13403753"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36350"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_4_1"/>
    <dbReference type="InParanoid" id="F9X1Z0"/>
    <dbReference type="OMA" id="GSEFYCY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="166"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="418"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61718" checksum="F9B095E35EA0442B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X212</accession>
    <name>F9X212_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GliM</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_35526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855805.1">
        <property type="nucleotide sequence ID" value="XM_003855757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X212"/>
    <dbReference type="GeneID" id="13403745"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35526"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_12_2_1"/>
    <dbReference type="InParanoid" id="F9X212"/>
    <dbReference type="OMA" id="MMMTANG"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389960" evidence="4">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="239"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP90781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="421" mass="46749" checksum="4E0E3BBF6BBF5221" modified="2011-10-19" version="1">MESTSLTSSLTLIATLVEAAGNHLSTDVNERILTEHLHGADLPTDAGIARLADRIIDAAEKLCTLLEPSHLILADHFLGYVSTKCLVGAVESGVPDVLAQAPCSLQQLAQATATHEQRLRQVMRLLCSNGIFSFDEDTAMYSNNPRSDLLRKDSSAPWRHWVDLYGNEFYDIARGIPRSLQRSTGRSAAQCNFNTDEDMFAYFERQGWVPRLHRTLASGMEAMAPGVVADYPWAEVADRTVLDLGGGGGALIATLLRAFPGMRGGILDLAGVIDHTRPFFREGGPYVDLADRVSDQDLQVGDFLQQVPSYEVYTIKWCLHDWEDEQAVQILRNVRSAIVRTETSRLVILEAVLRSEGRSARLARYGDINMMMTAKGRERTEGEWQGLVRTAGWQLAGIHRLRNSWLCAIDLRPAAEDRQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X215</accession>
    <name>F9X215_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_90360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855802.1">
        <property type="nucleotide sequence ID" value="XM_003855754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X215"/>
    <dbReference type="GeneID" id="13403742"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90360"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="F9X215"/>
    <dbReference type="OMA" id="DYLWNWD"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="380" mass="40419" checksum="C6D6AD2B3DC95081" modified="2011-10-19" version="1">MENLFSVAGLVAVVTGGGTGLGLYTAQALDANGAKAVYVVGRRADPLQKAAESAVNGSIIPLVGDVTDVDSLNDVVAVVEKEQGFVNVVFANAGTTGVCHDPDDNVQTGTAGQFQSKMLKPELLQEFTQILNVNTTAVFYTAMAFLELLDKGNRQGNVVQDSQIVVTTSAAAYDRSLLPTLTAYCTSKAASSGLAEILSTKFAQRSLRIRVNSLAPGHYPTEMNSAYMAMFPPYTNSRSEGAFQGARSLPREMCPAERSGSPEDIAGAVLFLASRAGAYLNGTTLLSLKVLPSPLFELAVHLPGSNFGNAPSNHIDGQLLVVLFDREGLHAIRRWAMLSHFQLVDQRKDLNMSDEVAEIVRIARSALDALPKFGNGQPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2E9</accession>
    <name>F9X2E9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_68561</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855480.1">
        <property type="nucleotide sequence ID" value="XM_003855432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2E9"/>
    <dbReference type="FunCoup" id="F9X2E9">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2E9"/>
    <dbReference type="GeneID" id="13403420"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68561"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="InParanoid" id="F9X2E9"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP90456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="459" mass="49405" checksum="86CEA5A890873A0A" modified="2011-10-19" version="1">MGDEAPTQRFETLQLHAGQEPDPTTKSRAVPIYATTSYTFNDSAHGARLFGLKEFGNIYSRLMNPTVDVLEKRVAALEGGVAAVATASGQAAQFMAIANLAQAGDNIISTSNLYGGTYNQLKVFFPRLGIHTKFVNGDSPADFKPLIDEKTKAIYLETIGNPRYNVPDLEAIAKIAHDAGIPVIVDNTFGAGGFFCRPIDHGADIVVHSATKWIGGHGTTIGGVVVDSGKFDWGTPDARKRFPQMSEPSDGYHGLKFFDTFGAITFAIRLRVEILRDLGAALNPFAAQQLILGIETLSLRCERHAQNAQKLAEWLEQNPNVAWVSYPGLASHKSHEIAKKYLPRGFGGVLSFGVKGGEQAGSQVVDGFKLISNLANVGDSKTLAIHPWTTTHEQLSDEEKISSGVTEDLIRISVGNEHIDDIIADFEQSFKSAATKPNQQGSDNANVTGDANAPTNPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2F0</accession>
    <name>F9X2F0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TMEM1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_90874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855479.1">
        <property type="nucleotide sequence ID" value="XM_003855431.1"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2F0"/>
    <dbReference type="GeneID" id="13403419"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90874"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001428_1_1_1"/>
    <dbReference type="InParanoid" id="F9X2F0"/>
    <dbReference type="OMA" id="YEIHANP"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="560"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="858"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="152187" checksum="9BDC9DB00A07C65E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2G9</accession>
    <name>F9X2G9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_84703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2G9"/>
    <dbReference type="STRING" id="336722.F9X2G9"/>
    <dbReference type="GeneID" id="13403408"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84703"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2G9"/>
    <dbReference type="OMA" id="FNFLAWH"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="38112" checksum="69D6CA8556A650BC" modified="2011-10-19" version="1">MRQNIGGRASASCTYANADVRREWRTLPRATRKAFTDAVTCLQKMKPRRMTVGQAKAYPGVKSRYDEYVATHINYTYNIHDTSDFFAWHRGFVHFLEQDLRDLCGYPGVMPYWNWSEDAEAPQNSPLFSGDTYSMGSNGRFVAGRTDTWLAQQDIVYPPGLGGGCVQRGPFTNYTVNLGPLSLPGNRNVASMFQYNPRCLERDINPWFSKKFTTYTNLTTLMLENIYLEDFQDLAQGYGSATNKFGVHGGGHWQIGGSMMDFNSSPSDPLMWLIWQYLDIWNRQFAISGTATLGCKSPDCPQMTLDDKLPFGFVAPDQTFRSLMDTMAGPLCYRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X383</accession>
    <name>F9X383_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855326.1">
        <property type="nucleotide sequence ID" value="XM_003855278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X383"/>
    <dbReference type="GeneID" id="13400722"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91126"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1037"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="InParanoid" id="F9X383"/>
    <dbReference type="OMA" id="ASMILQH"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="28433" checksum="C81D11FFDAA74C7B" modified="2011-10-19" version="1">MKLLCLHGVGGNAQMFEAQTNQITSVLKSYGHEFDFYDGAMDCEPPDDRIKQIYPPPYLAFYKSPIPEDVADAVDLIESIIEDEGPFDGILGFSQGCCVATSLMFERQKANTKPPFRFGVFIGASLPFNADDLSGKEVWEDIAASGKDPRSEFAGELELLQSGKEFILNNPDTVNEPVWLRRYHSLTTPAVKLQIPILHVMGSADPYVRQARTLASMHENAYDRLVIEHAGAHEVPRDAATNNKIAKHMLVMMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3D4</accession>
    <name>F9X3D4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D4"/>
    <dbReference type="FunCoup" id="F9X3D4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="13403700"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35885"/>
    <dbReference type="eggNOG" id="KOG4138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3D4"/>
    <dbReference type="OMA" id="CWKRQGN"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <end position="17"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
    <sequence length="687" mass="77184" checksum="ACFDD50EAB48944D" modified="2011-10-19" version="1"> </sequence>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Conde-Ferraez L."/>
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                <person name="Nap J.P.H."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855429.1">
        <property type="nucleotide sequence ID" value="XM_003855381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3T1"/>
    <dbReference type="STRING" id="336722.F9X3T1"/>
    <dbReference type="GeneID" id="13400976"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68710"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.827"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="F9X3T1"/>
    <dbReference type="OMA" id="CQKHMVD"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="28967" checksum="1FCC3C7617491C93" modified="2011-10-19" version="1">MSQQQPVLVQSASLHGKVALITGAGRGIGRGCAIELGKRGCSVVVNYANSKSSADEVCKLIEETGTGAKAISIQADVSKKAEIERLFEESKAHFGKIDIVMSNSGTESWDKTEEISEEKYDHVFNLNARAQFFVGQAAWKYLEDNGRLILMSSIAAGLLGVKDHVLYNASKMAVIGMIKGFATDFGARGITVNGVAPGGIKSDMFTQNAWHYIPGGSPDWPADKIEALMADHCPLKRCATPEDVARVVAFLASDDGGWVNGQVITISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V5</accession>
    <name>F9X3V5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_84756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855418.1">
        <property type="nucleotide sequence ID" value="XM_003855370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V5"/>
    <dbReference type="GeneID" id="13399860"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84756"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9X3V5"/>
    <dbReference type="OMA" id="CIRKIDW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF79">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP90394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="478" mass="52734" checksum="6E2E5832ECC35D10" modified="2011-10-19" version="1">MDMHGILSPEDAEFLASFPDEKRKKILRKLTSLRSFIDRANIGNAKIEGLENSLNMTGHQYNIALAVFFVPYTLAEIPSNIILNRFKRPSTFMGIIVSIWGLVMTCTGFVQGFSGLCITRVLLGLFEAGFFPGAILIISRWYLPHESQTRIAVFFTASAFAGALSGLLAYGIVRMDGVGGYEGWRWIFILEGIASVVAGLACFPLLIDTPALSQRWLDPEEIRYLEVRQVARQARQTEDNGKKFDFRVFKSVLLDWKIYCLILAFWSNVTPNYGLEFTMPQIMKNMGYTSANAQLLTIPAYTVGAISAYGFAVLSDRFRWRMPFIVGPQAAVAVAYAVLASKAENIKGNIPLCYFAVCLACFGLSPIGAGVQAWNLGNLAGPTKRAMGIGYMTCIGNMGGITGSFIFIQGEAPKYQTGFGASMGFASAGIIACLVMEYGLWSINKKNAKFTEDEVRAKYSDDELDRMGDKSPLFKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4A0</accession>
    <name>F9X4A0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_68153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855628.1">
        <property type="nucleotide sequence ID" value="XM_003855580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4A0"/>
    <dbReference type="STRING" id="336722.F9X4A0"/>
    <dbReference type="GeneID" id="13399373"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68153"/>
    <dbReference type="eggNOG" id="KOG0849">
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    </dbReference>
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    <sequence length="709" mass="76933" checksum="61D2870FC7837BEF" modified="2011-10-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Crane C.F."/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>F9X5B5</accession>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
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        <property type="protein sequence ID" value="EGP89521.1"/>
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        <property type="nucleotide sequence ID" value="XM_003854497.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X5J3"/>
    <dbReference type="GeneID" id="13404056"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69507"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.264"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="F9X5J3"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="314" mass="32990" checksum="511ABB345E5E02AD" modified="2011-10-19" version="1">MPVPREEYISDVWRDGIFTNKVLFCTGGAGSICSLQVRAFVALGGNAYIVGRNHEKTEAMAKDLTTARSGSKVIGQGGVDVRDPKLLEEAAKRCAKELGSIDFAIAGAAGNFLAPLSQLSANAFKTVMDIDTLGSYNTAKAVLPHLVESAKKYPNTGKPSRNGTGGRLIFISASFHYRGAPLQAHAAAAKAAVDQISHAVAIEYGPLGVTSNVITPGPIRGTEGMERLAKQDPESAKASAKAIPIGRWGEAREIADATVYVFSEAGSYVNGNVLVVDGGHWRTSGAAEKGWAYPDFLISGKAVEGVKSGRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X616</accession>
    <name>F9X616_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_108425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854635.1">
        <property type="nucleotide sequence ID" value="XM_003854587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X616"/>
    <dbReference type="STRING" id="336722.F9X616"/>
    <dbReference type="GeneID" id="13403995"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108425"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.96"/>
    <dbReference type="eggNOG" id="ENOG502SP4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018410_0_0_1"/>
    <dbReference type="InParanoid" id="F9X616"/>
    <dbReference type="OMA" id="KANCARF"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="724"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="833" mass="92801" checksum="4C2A141540916631" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X669</accession>
    <name>F9X669_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_69582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854514.1">
        <property type="nucleotide sequence ID" value="XM_003854466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X669"/>
    <dbReference type="FunCoup" id="F9X669">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X669"/>
    <dbReference type="GeneID" id="13395700"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69582"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.334"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="InParanoid" id="F9X669"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130649" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="320"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="468" mass="52046" checksum="5AE4496C25613B46" modified="2011-10-19" version="1">MRLPLLGLLLGFVSLVAAVSTQGSKLLVVIENDADKSKYSQFWSDLEGRGFQITYKAPKDSSLSLFAHGVPAYSHLLLLPVKSKGLGPALTPNLLVDFVNQGSNVLLALTAEQATPSAVSSLLLELDIHIPADRTSVLVDHFNYDVDTSAEKHDVILMNSPIAPKAGVANFFATDGHIAFPHTVGQTLGNASPLLAPIVKAHSPTYSYNLKEEGDGVEDVWATGWQINLVSSFQARNSARFTVLGSAEALEDKWFDATVSTPRMKGKREKSGNRNFAKKLSAWTFKELGVLKVGNIKHYLAEGTQKNIANTSEVPSLDLNPSIYRIKNNVHYEIEVSEWDMDQWVPFTPPADDELQLEFSMLSPFHRLNLQSKGQTADASIYAAEFKLPDQHGIFNFFVEYRRPFFTNLEEKRTVTVRHFAHDEWPRSFVISGAWPWISGIWVTVAGWLVFVAVWLYSKPADEKVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6I6</accession>
    <name>F9X6I6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PrpF protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_38191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854213.1">
        <property type="nucleotide sequence ID" value="XM_003854165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6I6"/>
    <dbReference type="GeneID" id="13404553"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38191"/>
    <dbReference type="eggNOG" id="ENOG502SIH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_0_1_1"/>
    <dbReference type="InParanoid" id="F9X6I6"/>
    <dbReference type="OMA" id="MQRIPCV"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="42765" checksum="CE9E58B98AF5D531" modified="2011-10-19" version="1">MRHAPRRQRRMLPAVWMRAGTSKGLFLHQRDLPPQREKWAPIILAAMGSNDSDPKQLNGVAGATSTTSKVAVIAPSERPDCDVEYTFVQVSIGSPKLDFTGNCGNICSGVGPFAVDEGLVVVPPGAEHVDVRILNTNTGRVIVETMEVDEDGHYVEDGDLTLPGTRAAGSRIDVAFEKPAGSMTGLMLPSGQPTEFLHIPGTIVRPSADVTVSLVDAANPFVLVDSKSIPESIMATGADSAFFLDFIEAVRCRGAVQMGLAADLAAAAKTRGTPKIAMLSEPALTIDSGKEIPDVEVTAFSMGKVHGSLQLTGAVCLASAICTPGTIANTIAKKAEQYRIATGSVVTSRRDSGTDEGTTSRKVNLRHPTGTIGAEAQLRDGEVESVKLWRTARRLFEGNVCFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6N4</accession>
    <name>F9X6N4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AvrStb6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853676.1">
        <property type="nucleotide sequence ID" value="XM_003853628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6N4"/>
    <dbReference type="GeneID" id="13404015"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103572"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.158"/>
    <dbReference type="HOGENOM" id="CLU_2833125_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6N4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395377" description="AvrStb6" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7282" checksum="D64CEAE9FCB44BB5" modified="2011-10-19" version="1">MHAFKLCAVFSMMAATAFAHKCKPNPPASGYCYYSPTDMRACHHYHECKTPNGACGYNNKGEMVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X2</accession>
    <name>F9X6X2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_70045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853916.1">
        <property type="nucleotide sequence ID" value="XM_003853868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X2"/>
    <dbReference type="STRING" id="336722.F9X6X2"/>
    <dbReference type="GeneID" id="13395541"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70045"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.681"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6X2"/>
    <dbReference type="OMA" id="ATMYKMS"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="33928" checksum="87DC8621BF6F0138" modified="2011-10-19" version="1">MAHLNYARYGKDNVRVYKVQRNTDGTQDVTEMTVCTLLEGDISASWTHADNANIVATDTQKQTVYIKAKQHPVNPPELFASILGQHFIDQYSHIHVAHVNIIVHRWTRMEVDGKPHPHSFMRDGAETRVVEAVVRRGKGISIRSGIKGLLVLKSTGSQFHSFHRDEYTRLPETWDRVLSTESEAGWRWKHFSGAKEVEQEQAIFDKAHAAARKITLETFAKESSPSVQNAMYLMGEQILAAVPKVEAVEYSLPNKHYFEIDLSWYNGLKNTGKDAEVYAPQSDPNGLIQCTITRKVASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X720</accession>
    <name>F9X720_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MgBGN16.1</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_92113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854204.1">
        <property type="nucleotide sequence ID" value="XM_003854156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X720"/>
    <dbReference type="STRING" id="336722.F9X720"/>
    <dbReference type="GeneID" id="13404422"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92113"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_1"/>
    <dbReference type="InParanoid" id="F9X720"/>
    <dbReference type="OMA" id="FGGIAWH"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000128">
        <property type="entry name" value="Endo-1,6-beta-D-glucanase neg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395383" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="74"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="425"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="480" mass="51576" checksum="C8EC6314331222F0" modified="2011-10-19" version="1">MHIQTFLALAGSATLTCGLALQERASAAAYTTDKDLNYKNSPIGAPVSGNGSPNGRATWKLNIDDTSSGCKQTIDGFGGCVTDATVTSFNTLSSGAQSSLLKEMSHFSLLRHTIASSDLSGDPAYTYDDNGGNADPSLSGFNLGDRGNAMTTLLKSMKNLNSKIKILGSPWSAPGWMKLNKVITGTTNQNNLNDGYLDNSGPGYSQAFAQYFVKYIQALNNRGVSIDAITVQNEPLNSNAGFPTMYMFDYEQAQLVNNYVGPALRNAGIGADVWAYDHNTDHPEYPERVINGAGNYVGAAAWHCYAGTLNWTVLTDFHNKFPNKKQYMTECYTTNTTGLNWVAGFVMGPLQNWASGSIAWTLGTTDKNGPYLSAETGPCKVCRGLFTTSNGNYQLNVDYYVMAQFSKYIPVGATVLSGSGSYNFDNGGIQSVATRNPDGSRTVVIHNSFSNDVYVTLTTKSGQTWSGNTPANSVTSWILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X730</accession>
    <name>F9X730_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_85442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854200.1">
        <property type="nucleotide sequence ID" value="XM_003854152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X730"/>
    <dbReference type="GeneID" id="13404540"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85442"/>
    <dbReference type="eggNOG" id="ENOG502RD0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="InParanoid" id="F9X730"/>
    <dbReference type="OMA" id="FTIINYY"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="313" mass="35569" checksum="1DF727960339D2DD" modified="2011-10-19" version="1">MPRPTYTIEQLGQFYDRIRLPEKYRCHPDDASRASNEDRLDFLTTLQRHTLCYVPFENLDLHYSRCPNIDLHPTSLFQKIVCRPHGKVSESKRGGYCMENNTLLATVLRSLGFRVMSGNGELMFYGFSHMANIVTIGSIRYLVDVGFGAGCAVKPLPLVDGHEQSNLPMQQVRLRWDTLAESEDPDAKLWILERRDAAAEPWSAVYCFPDRVEFLPADFAVMNHFTSTSRACFFTHTVVVVKYLLSEDGSQVIGEMVLVGDRLHWRVAGRKEILGVLTNESERVDALEKFFDIRLTEMQQSAILGLGSMLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7D9</accession>
    <name>F9X7D9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853965.1">
        <property type="nucleotide sequence ID" value="XM_003853917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7D9"/>
    <dbReference type="GeneID" id="13404304"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91909"/>
    <dbReference type="HOGENOM" id="CLU_1972208_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7D9"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="127" mass="14196" checksum="BC803D40E2E778D0" modified="2011-10-19" version="1">MDTYPFRYNFHSHSNFDSIHKTSPISSTTMKLSIQLVYLAATFFAGQALAAPAAEADADAARAYPNCNKIREPELQLQGFPLQRVHVRAQLDSISSGPSRHSRRSSDGRTNGTERGSRHPMFSRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7X9</accession>
    <name>F9X7X9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_85339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853978.1">
        <property type="nucleotide sequence ID" value="XM_003853930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7X9"/>
    <dbReference type="STRING" id="336722.F9X7X9"/>
    <dbReference type="GeneID" id="13395487"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85339"/>
    <dbReference type="eggNOG" id="KOG1853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7X9"/>
    <dbReference type="OMA" id="NMAIERS"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="128"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="571" mass="62789" checksum="B3BDF2AEDE2BD1E3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8E8</accession>
    <name>F9X8E8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_92589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853006.1">
        <property type="nucleotide sequence ID" value="XM_003852958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8E8"/>
    <dbReference type="STRING" id="336722.F9X8E8"/>
    <dbReference type="GeneID" id="13400218"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92589"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.459"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_6_0_1"/>
    <dbReference type="InParanoid" id="F9X8E8"/>
    <dbReference type="OMA" id="ILCSFPN"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38419" checksum="94BFA51453E37563" modified="2011-10-19" version="1">MADGSRIERLHTHDLELGATEVLQKHVSRHVVAEKRVSQRKLDFERSRPRWLRECIAEATGVFFYVFPGIAAITAFTINKEDAAFGSLFSVGMAFAFGIAFAIITCGPTSGGHFNPAVTISLAIYQGFPWKKVPYYIFSQVFGSFMAGLLLMGMYHEQIQSYTAGLLADGGREVMNGGPASFLVSFPTEDQQNLGYLFLIEFFVCSYLGIVIWAVLDPANPFVSPAGAPFVIGLAYATMVWAFADITIGTNMARDLGARLVALIFYGREAFTYRSYSWIPILVNIPATVLAASFYELIMRDSLQVIGKGAALHEDGEEGLTRHLTSTGMIRATGDVYFSNESDDSKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9J0</accession>
    <name>F9X9J0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_57921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853448.1">
        <property type="nucleotide sequence ID" value="XM_003853400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9J0"/>
    <dbReference type="STRING" id="336722.F9X9J0"/>
    <dbReference type="GeneID" id="13397282"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57921"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="InParanoid" id="F9X9J0"/>
    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
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    </dbReference>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Conde-Ferraez L."/>
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                <person name="Stergiopoulos I."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="410" mass="45180" checksum="07528089E2C6608A" modified="2011-10-19" version="1">MLATSRTAADLKPLESKHANLANASFPPESTLLPLPAFAKTGQRPAKSKPSKYLFKSQSTPHLRARNIMSESELQAKRNKLGYQRISIACAHCRRRKIRCLMSENEGEGRCANCIRLKKECVFYPVDQQAAIDAQAESSAGGRTNNGSRASSAASISPPLGATRPFDHQHQTNGSTYSVSSADDRSVYIGIPIAPSHSQPPLGSMSAPIPQQSQFEQSHREFTSAQYGFAPSGDMSSLDHHAPNFSRPILTTDAHLAFASQPPISNASSYSISSPVDAPQYTYSPISPYDHSSQTPQHAQWPLQQPPVVRSMSYTGPVPSYSQQQPSSIYQPAFTQPEQRQPPVIQAPQQHDPRMVQYTNYHATPPSAAQHQAHAYMQPWPPQYHQHYQAVQPLQSNWFGETTGRSSRHS</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851894.1">
        <property type="nucleotide sequence ID" value="XM_003851846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD18"/>
    <dbReference type="GeneID" id="13393671"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43052"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.232"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="F9XD18"/>
    <dbReference type="OMA" id="ALYLFWV"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51386" checksum="E7246FAE9AD93A69" modified="2011-10-19" version="1">MASDAKEPATPSTHSAPSEQQQQKVKVKWYRSTVYNALILGICNFCAPGIWGAMNSLGGGGSQQPWLINAANSLTFCLMVVTCIMSGIFVKYLGIKWTLIVGAAGFCPYAAGLYCNNRYDSHWFVLFGAACCGLGAGLFWMAEAAVAMSYPEPYNQGKFLGLWLSFRILGQILGGAVNLGLNADRNTAGSVSYSVFQVFIAIQAAAPFAGLLLTNPPDVQRTDGVTVSCSIEKSESSIQELKETGKLLIGRKFVLVIPLIANSVFAEAVFFTYQGLWFSVRARALGSLLSGIVAIVGGNVLGAFLDNKKIAARKRARWSFIGIMTMQGAWWTYGTILVTGYHKTHPSFDWIDSGFGRGFTWFLVMVMSFQINYMYLYFVMASIAKNDAEIIRYAGLLRATESASQAVSYGLTSVKIMGEVGCVYLNFGMWAVAVIPAWFVIREIGVSTGKIIDKRSEDEVREVRVDTKTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDA7</accession>
    <name>F9XDA7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NAG1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_100496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851857.1">
        <property type="nucleotide sequence ID" value="XM_003851809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDA7"/>
    <dbReference type="STRING" id="336722.F9XDA7"/>
    <dbReference type="GeneID" id="13401543"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100496"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.320"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="InParanoid" id="F9XDA7"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395607" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="185"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP86833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="576" mass="64463" checksum="16AD30F132798275" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEY9</accession>
    <name>F9XEY9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_94308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850617.1">
        <property type="nucleotide sequence ID" value="XM_003850569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEY9"/>
    <dbReference type="STRING" id="336722.F9XEY9"/>
    <dbReference type="GeneID" id="13401085"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94308"/>
    <dbReference type="eggNOG" id="ENOG502R1BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="InParanoid" id="F9XEY9"/>
    <dbReference type="OMA" id="KYEWSRR"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="612" mass="67784" checksum="097AC26266C41E59" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF59</accession>
    <name>F9XF59_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850973.1">
        <property type="nucleotide sequence ID" value="XM_003850925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF59"/>
    <dbReference type="GeneID" id="13397713"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94786"/>
    <dbReference type="HOGENOM" id="CLU_1042838_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF59"/>
    <dbReference type="OrthoDB" id="10379241at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="267" mass="30331" checksum="C9245CB2B9057B64" modified="2011-10-19" version="1">MSIQPTHPMGAMNKIAKDTSNRKNPNRKKKLEYPPNGYQAPKSLLRVHSPEDITRNHGRVLQIWTMCRKPWGAPNNGCRSAHRNFYVWHNGVLREVWKCVRDVCDWDGHEAEEDEEGDGDGDDGDEAGGGGDDTGGGFNDQVDDRDSMAGGDTEEDEPGKGMEEMLKKHNEAKNKTQQSKMRHTDFNVKVHKKQLTARPFKIDASFTMRKKQCDEIDCESACEQHGARVRRVRLGRKGQELSHLSERLLLGEQKGSLWHERMLAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFL2</accession>
    <name>F9XFL2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_44713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850673.1">
        <property type="nucleotide sequence ID" value="XM_003850625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFL2"/>
    <dbReference type="STRING" id="336722.F9XFL2"/>
    <dbReference type="GeneID" id="13397411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44713"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.267"/>
    <dbReference type="eggNOG" id="KOG2163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006571_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFL2"/>
    <dbReference type="OMA" id="REVQYSQ"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="663"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="816" mass="89848" checksum="5D12C14864F77169" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFS7</accession>
    <name>F9XFS7_ZYMTI</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_110181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850655.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9XFS7">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFS7"/>
    <dbReference type="GeneID" id="13397895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110181"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054226_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFS7"/>
    <dbReference type="OMA" id="FLQWGFH"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="43796" checksum="BE1DB5D0C6C4A854" modified="2011-10-19" version="1">MNPSGLLFRRTAPRVQTPLRQKRWAQVSDVRFYAIKPDPTERYREALERKAREKGLKDANELREAYADRIKRLRKESMVPGLNTAIEEEGSSTPSNPQPHRPPPQPRDAASSIPYQPPPPPQPQATPSSKPQSSSSKSSSAPPVRTLSSFIDVEKSSSLPQKELETIWRLRHVRDPQSLAAVLPSSTYNRIATTAKQHPQFVLPIPHPDRGAEIHFLQWTFPSPTTATVLFTHLAEFKLRGEFAQPHTTVTYHVDFAEEKGLVLMEGRVQEGKGVSVEEGRFLVMGLQKFYGWEGKGEGKRRRLMEQFSGGDEGFRVEELLEETEKVPRQISVYKEERRPYHKLGEARFQRKQTAAHSLGASAKTVSRTLMPLAVVYTVPPSHLPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFV5</accession>
    <name>F9XFV5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_86872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851140.1">
        <property type="nucleotide sequence ID" value="XM_003851092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFV5"/>
    <dbReference type="STRING" id="336722.F9XFV5"/>
    <dbReference type="GeneID" id="13397454"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86872"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.371"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="F9XFV5"/>
    <dbReference type="OMA" id="FMGHEFS"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="367" mass="40039" checksum="6341FEE9D4D15AAC" modified="2011-10-19" version="1">MQAARFHAANDIRVESIPKPPPSSNQVLIEIDWCGICGTDLHEYIAGPIAIRPHSHPHPLTNTTYPVTLGHEFCGRVVETSPSSSLQVGQRVMIDPRINCKDACHSCNHGIDNLCSSWGFLGLHSPTGGGFSQYAAVDARMCYTLPDSVRMDEAALIEPLAVARHALAVSEIPRGDWPAKSVLVLGGGPIGLAVLWDLRAVGAKMLFVSEPTEVRSRHTKDLASHVFNPREVDVAEECRTSTDGLGVDVVFDCAGIQAALKVGMDALKIRGVYVNVAGWEKEFSVPFGPAMTKELTVKFTLAYDYKDFQDVVDDFVAGKFEGVEKMITSRIALQDVVTKGFDELINNKDEHVKILVTPREDFLAAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFX0</accession>
    <name>F9XFX0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_94509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850721.1">
        <property type="nucleotide sequence ID" value="XM_003850673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFX0"/>
    <dbReference type="STRING" id="336722.F9XFX0"/>
    <dbReference type="GeneID" id="13397870"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94509"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.388"/>
    <dbReference type="eggNOG" id="ENOG502S50Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031471_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFX0"/>
    <dbReference type="OMA" id="YVKYQRR"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390510" description="DOMON domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="41913" checksum="F3557BEB18F35F41" modified="2011-10-19" version="1">MKASAAIMTALALVPMSSASYMTRQCFDANAVCFTLNVPGPTAQSGSGDIFFQMTAPTSMNWVGLGQGSKMAGSNMFVMYTSSDGQNVTISPRLGMGHEQPLYDNAANFTLLDGSGVQNGNMTANVKCSNCNSWSGGSMEFTGSTAEWIYGYKDGAEMNSDAEDARIKEHSKYGSFSFNLTQARGGNSANPFTDQAYTVDNIPLVAPDEAAYPDTLLTAHGVVACAAILLFILGAILIRLASFSGLVWAHVGVQVFGFVALIAAVGMGIYMAMFEGFVAHPIIGLIVFGLLFVQPITGLVHHRLFKRTNARSASSWVHLTTGRSVIILGLINGGLGLQLAGQSRAVYIAYGVVAGVVGLVYLAAIIFGERKRSSTRSDSSQSTSKSAFDGSKMEQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG37</accession>
    <name>F9XG37_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_45102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850748.1">
        <property type="nucleotide sequence ID" value="XM_003850700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG37"/>
    <dbReference type="STRING" id="336722.F9XG37"/>
    <dbReference type="GeneID" id="13397830"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45102"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.455"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="InParanoid" id="F9XG37"/>
    <dbReference type="OMA" id="RLHKGVM"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391637" description="Peptidase M20 dimerisation domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
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    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="407" mass="43657" checksum="6BB164958BDFA799" modified="2011-10-19" version="1">MRLLLGRWIALVASTCLASGAQEPLLLSTAGKQLILKDDLIAFHKNLTQIESISGNEKEVGEWLLASLKAQGYHVEKQEVQKKPERFNVLAWPGEKRDAKVVLSSHIDTVPPFLPYKYTSNGSHSTIFGRGSVDAKGSVATQIIAVNELLSAGSINPDDVGVLFVVGEEVGGAGMRAANNLDLHPQAIIFGEPTEGKLASGHKGILQIVLSAKGKSGHSGYPWLGRSANEVLVRSLGALINLGEKLPKSDKYGTTTFNLGRMEGGVAGNVIAEMANASVAVRIAAGEPEEVETAVTKAIHHAVQEFLEDGKLEAEDVIDIDFSGQGYGPIAIDADVPGFDVFTVNYGTDIPWLKKTVEDQKRYLYGPGSILVAHSANEEILESDLFAAVEDYQRIILHALGKGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG91</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_94597</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94597"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119195_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG91"/>
    <dbReference type="OMA" id="RTVPWMY"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391638" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="17134" checksum="054BD15C43F37565" modified="2011-10-19" version="1">MVLSRFLALCLFIASTIAQPVDGNAPSSAIPIAVGGKDPEIAKAVIALMLPEYDALSELIPLLAGENTIPASMLGSNSKSAMPQVPKAIFVGGGFSESEIISMYNGTSLQMVPWVYPLTQKRVEGTIPPTPEMIVARVKQVFAENGFVAGNEDNVKPGVWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGF5</accession>
    <name>F9XGF5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="9">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_10502</name>
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    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP86274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGF5"/>
    <dbReference type="FunCoup" id="F9XGF5">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGF5"/>
    <dbReference type="GeneID" id="13395287"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10502"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001908_3_0_1"/>
    <dbReference type="InParanoid" id="F9XGF5"/>
    <dbReference type="OMA" id="SGNNWMA"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="984" mass="108610" checksum="84445687C9F36E53" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGG3</accession>
    <name>F9XGG3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851295.1">
        <property type="nucleotide sequence ID" value="XM_003851247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGG3"/>
    <dbReference type="GeneID" id="13395292"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94239"/>
    <dbReference type="eggNOG" id="ENOG502RCGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1983334_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGG3"/>
    <dbReference type="OMA" id="NTCTICR"/>
    <dbReference type="OrthoDB" id="3649685at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="126" mass="13607" checksum="71CE4B32BDF00118" modified="2011-10-19" version="1">MSDTCRICKQNISDCSCAVKMAYDNCPICRQNISDCCCAVKNQLASDTCPICRQNISDCCCAVKNSKAVSDNCPICRQNISDCCCAVKNQLAYACLAYDTCPICRQNISDCCCTAKNGLQHAGVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGN4</accession>
    <name>F9XGN4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_17296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850816.1">
        <property type="nucleotide sequence ID" value="XM_003850768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGN4"/>
    <dbReference type="GeneID" id="13397768"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17296"/>
    <dbReference type="HOGENOM" id="CLU_028200_25_2_1"/>
    <dbReference type="InParanoid" id="F9XGN4"/>
    <dbReference type="OMA" id="CVNINAL"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="178" mass="19969" checksum="99013465730D2310" modified="2011-10-19" version="1" fragment="single">LYVLTAFFTKLSLVLLYLRIFPADVDNRQFRLICKLVGVVLFLAGFSCVLANIFACHPISYAWRYTGRADGACVDRIASAYAVGSINAVLDIVVITLPIPRLFKLNVALRQKVGVILCFLVGFLVTGVTIVRLYYVHSLIQYQNATWTWNTFVVWCAVEVYCSMICACMPPMIGLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGN5</accession>
    <name>F9XGN5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_105313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850817.1">
        <property type="nucleotide sequence ID" value="XM_003850769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGN5"/>
    <dbReference type="GeneID" id="13397555"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105313"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.580"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="InParanoid" id="F9XGN5"/>
    <dbReference type="OMA" id="FCPSPLW"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
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        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP85793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="595" mass="64811" checksum="88D55145E953183F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH22</accession>
    <name>F9XH22_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="10">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_75137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH22"/>
    <dbReference type="STRING" id="336722.F9XH22"/>
    <dbReference type="GeneID" id="13394593"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75137"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.668"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="InParanoid" id="F9XH22"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="118"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="346"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85137.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58556" checksum="8CD8938EFC4889D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH29</accession>
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            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">MYCGRDRAFT_75146</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
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    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850166.1">
        <property type="nucleotide sequence ID" value="XM_003850118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH29"/>
    <dbReference type="STRING" id="336722.F9XH29"/>
    <dbReference type="ESTHER" id="zymti-f9xh29">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13394442"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75146"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.676"/>
    <dbReference type="eggNOG" id="KOG1516">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_0_1"/>
    <dbReference type="InParanoid" id="F9XH29"/>
    <dbReference type="OMA" id="KAVMFWL"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130620" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="27"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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        <property type="protein sequence ID" value="EGP85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850210.1">
        <property type="nucleotide sequence ID" value="XM_003850162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHD6"/>
    <dbReference type="GeneID" id="13394563"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95460"/>
    <dbReference type="eggNOG" id="ENOG502STU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476681_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHD6"/>
    <dbReference type="OrthoDB" id="10487013at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="572" mass="63300" checksum="E539A20928F96D6D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIA3</accession>
    <name>F9XIA3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_46026</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850085.1">
        <property type="nucleotide sequence ID" value="XM_003850037.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XIA3">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIA3"/>
    <dbReference type="GeneID" id="13394286"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46026"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIA3"/>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1223"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="165"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="392"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1316" mass="147701" checksum="F174D9996F607F87" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIB5</accession>
    <name>F9XIB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_95274</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850315.1">
        <property type="nucleotide sequence ID" value="XM_003850267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIB5"/>
    <dbReference type="FunCoup" id="F9XIB5">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIB5"/>
    <dbReference type="GeneID" id="13394294"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95274"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="InParanoid" id="F9XIB5"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="54"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="665"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="790" mass="85720" checksum="251CB3C128509788" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIQ6</accession>
    <name>F9XIQ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secreted peptidase S10</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
            <ecNumber evidence="7">3.4.16.5</ecNumber>
            <ecNumber evidence="7">3.4.16.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PEP-S10.1</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_75070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EC" id="3.4.16.5" evidence="7"/>
    <dbReference type="EC" id="3.4.16.6" evidence="7"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850136.1">
        <property type="nucleotide sequence ID" value="XM_003850088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIQ6"/>
    <dbReference type="MEROPS" id="S10.014"/>
    <dbReference type="GeneID" id="13394412"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75070"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="InParanoid" id="F9XIQ6"/>
    <dbReference type="OMA" id="WSWHRIT"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391690" evidence="6">
        <location>
            <begin position="19"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="506" mass="56058" checksum="FA5E0DA969E2B7D8" modified="2011-10-19" version="1">MHAAYLTSILAWTRAVAAVSGGSRTFDKRLVDTSLFNAPGNSPNLQRRQNANTSAFAIDGSKIPGVDFTLDESYAGLLPISSDADEKSKLYFWYFPSTNKDADDEITIWLNGGPGCSSLEGFMQENGPLSWKPGTYKPVKNRWSWHHLTNMVWVDQPVTTGFSQGPRVVNNQEDLSRDFMGWLKNFIDTFGLHGRKIYLTGESYAAGMYIPYMAYYMLEANDKTYYNLQGTLGYSPALNWFAVTEQIPSVPFIDRWAPLFNLNSTFVDAMHKASDACGHTKFLNDYLTFPPPPGPMPDPPDGLVYREGCDTWTAILNATFLVNPCFNIYHIPDTCPFLWDILGSSPGPDGFFNRTDVQAAINAPPTNYILCNQTDQVFPNGDASEWSSFGDAGQKAILPQVIERSARTMLVGGDLDFIIISDGVLLSIQNMTWNGAQGFQQRPSDPFIVPYDGDSNYAAVGVLGVTHTERGLTWVNMAGSGHMGPRYAPAGAWRHLEYLLGRIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIR5</accession>
    <name>F9XIR5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_110580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850142.1">
        <property type="nucleotide sequence ID" value="XM_003850094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIR5"/>
    <dbReference type="STRING" id="336722.F9XIR5"/>
    <dbReference type="GeneID" id="13394418"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110580"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.614"/>
    <dbReference type="eggNOG" id="ENOG502S4P6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024752_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIR5"/>
    <dbReference type="OMA" id="CKDHLKH"/>
    <dbReference type="OrthoDB" id="4505556at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="447" mass="50484" checksum="AAE1B2B6774C5199" modified="2011-10-19" version="1">MASAAGDNIMSGINISKEITCQIVDNLMGPRPDSRYNWPVEALADISSTVRQDLAHARLINKAFCDCVTPLLFRDIKAYFPYPSPELKPSVWAKDILKLSSSRVAGHVKRLEIGFLSWPRTTDPPEFFLEEVLLEALYAIPALVSACRGLRILKIEGSPRDRDDAPVLSQLHRRMFNQCIDQVFRILSQGNDYTGPKAILMSLPLAHDYGQRYSRSLEFHSGTYTNPLTQVLESIHRLEVTISDVTGSGGQRYWPRSESAGHARHPNIRHQSELWEFIGLAKQLRVLTIQCSHVLNFDNFPVDGLQHLRELGLIRVSMSETQWSKLLDRTRSSLKAMELTLVDLTSGTWESCLLQLCTMSHLDHFFIDSCGYTANGASSQHALGLLPAPDEQTNIETMHFTDENALGHVQRHVNAVRQAAGMDLYDETYYRYLSSRSLEEEGRLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIX1</accession>
    <name>F9XIX1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849429.1">
        <property type="nucleotide sequence ID" value="XM_003849381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIX1"/>
    <dbReference type="GeneID" id="13402472"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105739"/>
    <dbReference type="HOGENOM" id="CLU_2238756_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIX1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="105" mass="11973" checksum="01B999F245E99E94" modified="2011-10-19" version="1">MEVRGLVVRVESRRKSAVALFELRDSCRNDGEYVPSTFMSKCELFSDGIRLAFPLCDTRSVQPCLDTATTSDTFRPVHFQSSSRARSDCPRYAMKSHQFVLMLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ26</accession>
    <name>F9XJ26_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_95557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849815.1">
        <property type="nucleotide sequence ID" value="XM_003849767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ26"/>
    <dbReference type="FunCoup" id="F9XJ26">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJ26"/>
    <dbReference type="GeneID" id="13402612"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95557"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.100"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ26"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128720" checksum="FA48B760707AB3BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKS2</accession>
    <name>F9XKS2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_76305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849134.1">
        <property type="nucleotide sequence ID" value="XM_003849086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKS2"/>
    <dbReference type="FunCoup" id="F9XKS2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKS2"/>
    <dbReference type="GeneID" id="13398606"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76305"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.266"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_1_0_1"/>
    <dbReference type="InParanoid" id="F9XKS2"/>
    <dbReference type="OMA" id="AQCTSHF"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="22209" checksum="D0675DB110737B66" modified="2011-10-19" version="1">MLFDEDPVNIMAEATNRFHTAPDKDSLSRVTESLHLLASARQQRIDDQASVLSALSRRLNNLKSQHSYEEERHDAGKHAAEMLKMDTEKFRIAKGVNDAEIESERLSGELAALKQQLQTLEKEGVEGGARGGRNEEQQDATVLKLSFYRSLGIDISQDASTGEYNRAVIRNSTRGDVNVVNVDGTMGTSFYSNMFWNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKT4</accession>
    <name>F9XKT4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_48308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848980.1">
        <property type="nucleotide sequence ID" value="XM_003848932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKT4"/>
    <dbReference type="GeneID" id="13398300"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48308"/>
    <dbReference type="eggNOG" id="ENOG502RUPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2265844_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKT4"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11643" checksum="FD4A0BAF8BEB4E25" modified="2011-10-19" version="1">MRELMTYKYMGPKSASVVMGWCLKRDSFTVDVHIYRIAGLWHWRPEKATKELTQSHLNARIPKDLQFDLHFLLLQHGRECPACKGGAKSGAVCLLKGKDAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX4</accession>
    <name>F9XKX4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MgSTT4</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_75991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849233.1">
        <property type="nucleotide sequence ID" value="XM_003849185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX4"/>
    <dbReference type="FunCoup" id="F9XKX4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKX4"/>
    <dbReference type="GeneID" id="13396588"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75991"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKX4"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="163"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="742" mass="84190" checksum="CC9E26C91C414FF2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL28</accession>
    <name>F9XL28_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL28"/>
    <dbReference type="STRING" id="336722.F9XL28"/>
    <dbReference type="GeneID" id="13398039"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111040"/>
    <dbReference type="eggNOG" id="ENOG502R7TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_2_2_1"/>
    <dbReference type="InParanoid" id="F9XL28"/>
    <dbReference type="OMA" id="ECVELWD"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43823" checksum="66D3FABEAF8E1323" modified="2011-10-19" version="1">MLYNCLKMGRPTINGNLQMWHPSSSTPALRKIWTLVLFLLCCFIFYVGRTHLSGPRRPWFDHADIIPHKMWQSWKVDALSFEDRDSERARAWTAKNPDWRYEVLTDGNAVAYVEQHFGPKGFGRPDIVKIFKALDGRLKIIQADLLRYLIMYVEGGLWADIDAEALSPISRFIPSRFEESSVDMIIGIETDEPDFLTHPILGSKAQSFCQWTFLTKPGHPAMLTLVEDILQWLKRLSTESGKAIADLDLDFDQVLSGTGPSAFTHAILAHMSATIGREVTWSENFHDMSDSTLVGGTLVLPAEAFAAGTGHSRSGTHSGSRALVKHHFHASGWTSKHPRRKHPVYGEVERCNWNKACVELWDENVGAFSKLSQQQQSEMIRTTQARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL60</accession>
    <name>F9XL60_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_96243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848886.1">
        <property type="nucleotide sequence ID" value="XM_003848838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL60"/>
    <dbReference type="GeneID" id="13398131"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96243"/>
    <dbReference type="eggNOG" id="ENOG502R945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324448_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL60"/>
    <dbReference type="OrthoDB" id="3635808at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="350"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="643"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="100860" checksum="99903ED8CEB44909" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLL3</accession>
    <name>F9XLL3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_82331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848823.1">
        <property type="nucleotide sequence ID" value="XM_003848775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLL3"/>
    <dbReference type="GeneID" id="13397993"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_82331"/>
    <dbReference type="HOGENOM" id="CLU_2869383_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLL3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="64" mass="7129" checksum="613D417789CF14B3" modified="2011-10-19" version="1">MVTVTADIADAEALSLYSHREGESEEELRNGGHLRRYQRAMYPAIGGRMCWRIIDVVGGCVNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLQ8</accession>
    <name>F9XLQ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Siderophore-dependent iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_76487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP84048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849072.1">
        <property type="nucleotide sequence ID" value="XM_003849024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLQ8"/>
    <dbReference type="GeneID" id="13398176"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76487"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.402"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="F9XLQ8"/>
    <dbReference type="OMA" id="MTTIPIV"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="65"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="582" mass="63448" checksum="611D02F021EE764C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>F9XM80_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_106229</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848520.1">
        <property type="nucleotide sequence ID" value="XM_003848472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XM80"/>
    <dbReference type="GeneID" id="13396475"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106229"/>
    <dbReference type="HOGENOM" id="CLU_2607870_0_0_1"/>
    <dbReference type="InParanoid" id="F9XM80"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390858" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="79" mass="9022" checksum="7B2BA415D2D1ED6D" modified="2011-10-19" version="1">MLWISGALLGCVTFLVLTAKGLPAQAQPPTTSIDRTISTPPSKRWDHTYFGVMFNRFADENCEMKSLDRFDKDDERNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMA1</accession>
    <name>F9XMA1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID, subunit TAF5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAFV2401</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_101670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848508.1">
        <property type="nucleotide sequence ID" value="XM_003848460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMA1"/>
    <dbReference type="FunCoup" id="F9XMA1">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMA1"/>
    <dbReference type="GeneID" id="13396456"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101670"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005884_0_2_1"/>
    <dbReference type="InParanoid" id="F9XMA1"/>
    <dbReference type="OMA" id="HNHPVWD"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="87"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="535"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="733" mass="79470" checksum="965FF351844F72E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMQ0</accession>
    <name>F9XMQ0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_14773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848684.1">
        <property type="nucleotide sequence ID" value="XM_003848636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMQ0"/>
    <dbReference type="GeneID" id="13396377"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_14773"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="F9XMQ0"/>
    <dbReference type="OMA" id="FANSICD"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="65"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="33234" checksum="C7E309FB128C37A3" modified="2011-10-19" version="1" fragment="single">CICYNKELQAALGTCVLSSGCSIADALVSQRVQAETCGFPVRDRSDTFRITQSVLFPLATLTVCLRMLSRSPMSGAGFGWDDWVVLLCVLPMTGLIVTSYMEVDSGLGQDIYRLSIPMIKHCLMYFYIGNTFYSPVIFGTKISFCLLYLRIWRDAGLAFRRACQVTAVVLGMALISFEFSTIFICTPPSYAWNALTGAKGHCIQRDAQLFTNSAFNIAADFVVLLLPIPKFLHLTMSRGKKAGVLVTFLVGFAVTAVSITQLVYLVRNVGKISNPTWDYFPIGLWRCTEVYLSMICCCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN83</accession>
    <name>F9XN83_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848584.1">
        <property type="nucleotide sequence ID" value="XM_003848536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN83"/>
    <dbReference type="GeneID" id="13396265"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96703"/>
    <dbReference type="eggNOG" id="ENOG502TDD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_889061_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN83"/>
    <dbReference type="OrthoDB" id="2561193at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="313" mass="35009" checksum="8A6DCD4A08486063" modified="2011-10-19" version="1">MSSSSTPPFHRLLSFYSNRNPHDSQTIRLQDSLRGNLSLGLDFPVALAVALGRHLYLKNTTFFSLNIHVPSVKWHTTPLHGVEVDEKKEYTRAEIMEVVRREKGFMAGLDALGVWALAADVKTGRVKGGDVLAFQEGRLLGEVERRRKGREQVLPLWRGGPISVAGHSWFVGRIFGVEVYREGGGRGEVMMATCPESAVQDASNTTSDGRLASLDPRENMLAAFQDDFNGSDWSIRIRPSKHVFGKPTQSERTSRHLCTLYWETAKRCRIVATAETRGHLHKGHRSTSTTSQYNDDISSAHRRHCSTFSEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNQ5</accession>
    <name>F9XNQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_111475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847938.1">
        <property type="nucleotide sequence ID" value="XM_003847890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNQ5"/>
    <dbReference type="FunCoup" id="F9XNQ5">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNQ5"/>
    <dbReference type="GeneID" id="13401922"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111475"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774353_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNQ5"/>
    <dbReference type="OMA" id="YPGYKHA"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="358" mass="40278" checksum="17A06173E8B4BC5A" modified="2011-10-19" version="1">MAKNKKQRVHALHADSKSAAKVRHGKSPNTSKSGKPSKSSQPPPKKAEPTIPFQAEDRILLVGEGDFSFAKSIVEHHGCCDVTATCFDRQEELYEKYKPQAEEHVKYLEDEGQTVHCGIDATKLDKIKALKKQGGGRFDVILFNFPHVGGKSKDVNRQVRFNQELLVKFFNTGMELLAPEGTIVVTLFEGEPYTLWNVRDLGRHTGLEVRRSFKFMAEAYPGYSHARTLGNIEGGGGWKGLFTQEMEHDDIHFEIVEAGLTALEELDRYAMEQRLYHNSTTDASLPSDPDLTTGLKCRTTLDAEPDWTGIARRHIRGARYQGRLAGAVKPLLYNLRERLCMFKKLDSRSHVLNYISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNV7</accession>
    <name>F9XNV7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_101770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848125.1">
        <property type="nucleotide sequence ID" value="XM_003848077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNV7"/>
    <dbReference type="GeneID" id="13401937"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101770"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.264"/>
    <dbReference type="eggNOG" id="ENOG502QUGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_0_1_1"/>
    <dbReference type="InParanoid" id="F9XNV7"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34414" checksum="C25A974B8B38D885" modified="2011-10-19" version="1">MTIQHVHAIVNAYSPKETVELCGRAGYTKANMRLDKMFMSAVIAGMLLSFACAALLSTNASPWFQENAPGLLRTIAALIFPFGLTMIIVTGTDLCTGSFMITTIAALQRRISIPKMLLHWFVTFWGNLAGSLFVVAIITGYGGVFSAPVYQKTVFSFNASKVLVPTWHGVFLRGIGANWLVCMAAFLAYMAREYFSKVMAIWWPTFAFVCLGFDHVVANMFFVPTAIFLGDPAISVSFYIWKSLIPALIGNIIGGGLFVGVAYWYIHVSGEQGPISIDGGFFPGDQVVLNGRADDASERASSTERKPSHSSPEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNX1</accession>
    <name>F9XNX1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_77491</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847970.1">
        <property type="nucleotide sequence ID" value="XM_003847922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNX1"/>
    <dbReference type="FunCoup" id="F9XNX1">
        <property type="interactions" value="1149"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNX1"/>
    <dbReference type="GeneID" id="13401615"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77491"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="InParanoid" id="F9XNX1"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106068">
        <property type="term" value="C:SUMO ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061656">
        <property type="term" value="F:SUMO conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="157" mass="17979" checksum="E0FD2A2564B7A804" modified="2011-10-19" version="1">MSLTTARLQEERKQWRKDHPFGFVARPMKTPQGALDLKRWDCAIPGKDKTIWEGGLFKLEVIFPDEYPTKPPKCKFTPPLFHPNVYPSGTVCLSILNEEEGWKPAITIKEILLGIQMLLDEVNPDSPAQAEAYNLFKKDRAQYEKRIKSVVKDNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP28</accession>
    <name>F9XP28_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase 29/21K chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_17463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848091.1">
        <property type="nucleotide sequence ID" value="XM_003848043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP28"/>
    <dbReference type="STRING" id="336722.F9XP28"/>
    <dbReference type="GeneID" id="13402060"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17463"/>
    <dbReference type="eggNOG" id="ENOG502S2AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081626_1_0_1"/>
    <dbReference type="InParanoid" id="F9XP28"/>
    <dbReference type="OMA" id="HPYEINE"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16586" checksum="48E229271564456A" modified="2011-10-19" version="1" fragment="single">QKYTVQPVGIWGRIHKFFALDPARSSGVPLNPQFRNPPPGGNDPLEYTDAVTTPAADIADNPYWKRDVRRSYPKLSVVTQPDVVGLLSVGSAAAPKEDVLKIGDAGKNQLVEVKQEGEKGLSTYFEKNKGTFASVLGSDGLPPLPPSMNRQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPG2</accession>
    <name>F9XPG2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_77200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848231.1">
        <property type="nucleotide sequence ID" value="XM_003848183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPG2"/>
    <dbReference type="STRING" id="336722.F9XPG2"/>
    <dbReference type="GeneID" id="13401501"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77200"/>
    <dbReference type="eggNOG" id="ENOG502QR55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048127_2_0_1"/>
    <dbReference type="InParanoid" id="F9XPG2"/>
    <dbReference type="OMA" id="NAKEYRM"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="258" mass="28603" checksum="F1A0E330554A7E93" modified="2011-10-19" version="1">MVSSFPALSTTALKTCIETNLPLYSSIVPAKLTKLDEFRYNLRPRKNDSTSSSAPTLSKDDLISLVEWKLSHGTFRPALKNLVASNSDDITTDTIREAYALIPDGTIAESDVKASLTVLTRLRGIGPATASLALSVLRPDEIPFFSDELFRWSMWEQGKGKGWDRPIKYSVKEYLELFRLIAEARENADGEVKAVELEKVAYVLGKSNGGKAGTKRAAMDEESDEVKPEVREKKKVKVVTKPEKRSTRSSTKTKAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPN2</accession>
    <name>F9XPN2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_51107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847823.1">
        <property type="nucleotide sequence ID" value="XM_003847775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPN2"/>
    <dbReference type="FunCoup" id="F9XPN2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="13400767"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51107"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_2_0_1"/>
    <dbReference type="InParanoid" id="F9XPN2"/>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="395" mass="43930" checksum="12BC0D9A6A5CD7BF" modified="2011-10-19" version="1">MSSTTTHANVSTPDYTLTCPDDVKQLSHHKQRNQSFHNPWPSFVDPGGPAIMYKIMKRNLLGQANKPDTTNPAIEVLKPIFRAQSATKEEHSTIRATWLGHASYLLEFPSTSSNLTVIFDPVYTKRCSPLTFAGPARYTPAPCQPLDLPPIDVVVISHNHYDHMSYPDLTAIYAANPNAHFFMPLNLKKWFLTNGIGKASTITEMDWWQSADFTLPGSSSATATFSCLPAQHATARTGPDRNTTLWCGWSITTPHSQPNPKSVYFVGDTGYRSIPEKLDIDRAFDQHNPALKELPVCPAFAQIGKLRGPFDLALIPIGAYAPRWLFSGLHGDPYDAVAICEDVKAKKALAMHWGTWVLTEEDVTEPRELLKEAVIEKGFEEGRFVSMAIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPS4</accession>
    <name>F9XPS4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_77725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847535.1">
        <property type="nucleotide sequence ID" value="XM_003847487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPS4"/>
    <dbReference type="STRING" id="336722.F9XPS4"/>
    <dbReference type="GeneID" id="13401211"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77725"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.84"/>
    <dbReference type="eggNOG" id="ENOG502S2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043442_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPS4"/>
    <dbReference type="OMA" id="KLNALGH"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34669" checksum="ACAB7E728CBCE06E" modified="2011-10-19" version="1">MSTLIWPPIAHDQLLVEQADTVARELEWLLSTLQDTLRALKEGLEECAELLAPKEPGSTLVLSSIRSEHLKGFITRVGTRIVKGDVHLRLHSLPPAKGQSSYKLSISTLPTAPTLVLDQLTTTRTLINACLDVVDATLWTGDRQNASFISSQLRLLHENIQEAKTALKGWPEHLKPWNEQPAEPKAFLPPLPSNISFHLSISEAAVLLNVRVLELAHPHTGTNTPLSAPGGGAASFSGLSLRDRLATAFGVKPMPEGETAETFTYQGQEVRVKEKVRVESQDPSLMAALAKLGALERNVALARRALDVLMGIDGDTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPY6</accession>
    <name>F9XPY6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4267 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_51082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847775.1">
        <property type="nucleotide sequence ID" value="XM_003847727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPY6"/>
    <dbReference type="GeneID" id="13401196"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51082"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.152"/>
    <dbReference type="eggNOG" id="ENOG502ST1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797970_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPY6"/>
    <dbReference type="OrthoDB" id="5594884at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395728" description="DUF4267 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="14909" checksum="1E621F890B329735" modified="2011-10-19" version="1">MAYLLPSFKAVSIIFSFAAVGTGLQALIDPHGFSKSFGLPIVSSSASQLKPSKNGTPSSITNFADSYICLMGVRQLGTGILLMIFNYQHKYIEAATVLAVIGVLVAGTDGLFLARAGDRKGGLFHAGPGLAIAALAGAVLYHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ11</accession>
    <name>F9XQ11_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_77812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847585.1">
        <property type="nucleotide sequence ID" value="XM_003847537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ11"/>
    <dbReference type="FunCoup" id="F9XQ11">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ11"/>
    <dbReference type="GeneID" id="13401363"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77812"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.179"/>
    <dbReference type="InParanoid" id="F9XQ11"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="243" mass="25965" checksum="8CCB51FB4D3A8203" modified="2011-10-19" version="1">MPSSSTTDQLPTEVVTCLRNARFLHLATCTNNTPHVSLMHYTFLPSNSFPSTSSTLPSGPTIIMTTDPHSKKTTNLLANPSVSLLVHDWVSTRPPSTTSANASDRERSPASGHRSSLAAMLMQMNSTAVSSISATINGAARVLEQGTEEERWCKEQHLANNTFSSDGSEQGSFGTSPEERTGDSGRGSYIADQDVRVVVVEIKGGRISDWKGGVKEWSVAGSGGRDGQEERNGDIRTLVNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQK6</accession>
    <name>F9XQK6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847499.1">
        <property type="nucleotide sequence ID" value="XM_003847451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQK6"/>
    <dbReference type="GeneID" id="13400387"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106583"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.26"/>
    <dbReference type="HOGENOM" id="CLU_1994410_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQK6"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="125" mass="13839" checksum="40A4E0A3D27D8D6A" modified="2011-10-19" version="1">MSPRKAKSREAKLLKDDLKKQPAPRLPPTSKDRPSSRGRRMSASPQPSMQEDAPSIVDIPVSRPRCLISHQRHQLPLSSSHPLLPSLPPKAIHDLRYTSSLRIPMAVLVPLAERDHPSTTPSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQT2</accession>
    <name>F9XQT2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847435.1">
        <property type="nucleotide sequence ID" value="XM_003847387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQT2"/>
    <dbReference type="GeneID" id="13400368"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97602"/>
    <dbReference type="eggNOG" id="ENOG502T79Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742285_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQT2"/>
    <dbReference type="OrthoDB" id="10337377at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="373" mass="41509" checksum="315EDFE34364549A" modified="2011-10-19" version="1">MIGGSGPTKMQSIERNVQPVIWMGMTKKDILARKRLNMSSTAKLAILQDAAKNMWCKHFMTPRQLVDLLARLACPFAEGEDITEICMGKTLNTIAGLVVEQNLGPGLWCDIDQGFSLTKSLRKRILSSTTLAEAIDEPALEDKEQRKYLVTDITHLPKARLMRDALRLIKEEGHFHRGRKTKASVNSASNGMSHKSIDEMISLLKRTSSDRANGMLQTKFGLTLDDIISKGFHPFIFTAESDSDVDVDCSDQSEESSDESSSRHGAFLHEILPLDKDPADHSSSTHNRTGGYPSTTRDPRAMFSRFIGKLGLTYAITATDPFVPEPVQTQTSINLASIILAGSRETHTAAFDFFFFFFFLFETCSSTASLDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQX7</accession>
    <name>F9XQX7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847333.1">
        <property type="nucleotide sequence ID" value="XM_003847285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQX7"/>
    <dbReference type="GeneID" id="13400339"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97665"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_15.56"/>
    <dbReference type="HOGENOM" id="CLU_1612115_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQX7"/>
    <dbReference type="OrthoDB" id="10373527at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="18374" checksum="EB5211A42A489023" modified="2011-10-19" version="1">MSKPTASSSGSDAVDEDSKLCPKCNLVQPTSLFETLSKSRKANKYCRDCQPPSSRRVSRDLAPAPPSLRHRDRFGGAPDNIPDDFVDPPTGWDVSNISVRITELVTMVCARTALWVTMVCVRTAEWVTIQMGEDDAGDMMEMLQHEWQWYVLVLVAAVVMVLVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR75</accession>
    <name>F9XR75_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1497377_0_0_1"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="180" mass="19443" checksum="739325066A230F1E" modified="2011-10-19" version="1">MPDAGLNKSTAVHGEQDTIAAALTTSNAAGNRSSFEKAEKHSDGERPSVVGNSADKQADQNTKRKRSEAAMENVEDFTKALLVSGSEEEKGEPAQAKRSKIVHTIGKLTRTTTSTKNKVVKTPKSTISTPNLDVQERSITPKKAAPARPPRKKIDKVPVVLDSDEDLPSATDFVRDHSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847203.1">
        <property type="nucleotide sequence ID" value="XM_003847155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRF0"/>
    <dbReference type="GeneID" id="13399707"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97802"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.29"/>
    <dbReference type="HOGENOM" id="CLU_1939769_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRF0"/>
    <dbReference type="OrthoDB" id="10441395at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="130" mass="14287" checksum="6357C0193F9AC12A" modified="2011-10-19" version="1">MQLSIGLDWSSPWSAPHSLHLIARQAVAARFFQRDVQSLSLRVPANSPYRSGAALVELAVRVAGNQRHTEVVEQEDVDIKDGEAACAEEAELKQPQIRKESLPAAAIINHWLAGQDITATRATRGPHARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97885</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847092.1">
        <property type="nucleotide sequence ID" value="XM_003847044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRP0"/>
    <dbReference type="STRING" id="336722.F9XRP0"/>
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    <dbReference type="HOGENOM" id="CLU_811849_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRP0"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="139"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="342" mass="37112" checksum="C6ECB528732617AE" modified="2011-10-19" version="1">MAEAAAAWSDHDLSASRRLHRSDARIPRQVERDGRYGRRSLRSSTDKLTVSTFGRGFPKDYGRAASPARRANGEDKKVVIGAAASILSMAVDGLFKRTKKTELGSASHEKHLHANQRLPSYELGLRSDRPSSSFAQSAHSKLRRKTPRRKRQWLKCSESAYLDPIACPDRLSHIVVPLYCTLFFVIRINNPVGRCRGAANTVGISAEPLMLTRSGSASLDSHNKNDCSSDPGASVSECAYKADIIQQGFENIYLVASFQNRTAACSRSPSSEMRPDPSPAPTPNVSTPASPAQEAPKERDKLDLAKRTVSTAETNTASTLFGGAGASPFDAIGTLRKGPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRR7</accession>
    <name>F9XRR7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847109.1">
        <property type="nucleotide sequence ID" value="XM_003847061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRR7"/>
    <dbReference type="GeneID" id="13399461"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97912"/>
    <dbReference type="HOGENOM" id="CLU_1939766_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRR7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="15625" checksum="4FEF5908B5B83AA9" modified="2011-10-19" version="1">MSATTRSPRTQTEPTKAYKEWSTVDPSKILIPICLVHNKEQEEQNKKKTEELNALLESTTARIAQIEQEKREQEEASPYAHETVFYAQQETAALYYQMKTLEEQVPKAPFKQGAEDPMLSIEYPIDEFVEPMDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRV5</accession>
    <name>F9XRV5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_83234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847054.1">
        <property type="nucleotide sequence ID" value="XM_003847006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRV5"/>
    <dbReference type="GeneID" id="13399250"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83234"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.36"/>
    <dbReference type="HOGENOM" id="CLU_1797972_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRV5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="144" mass="15971" checksum="3EB43A8D3C3041AE" modified="2011-10-19" version="1">MAEVERGRASGRSINFDFNFLADLTCRRALELPRITAHSEEARPWRLSTLPQNSATCASQEPPACPETTLPAVVPSYVLAVVLTMEETDISSAIVLPLLPLWPPDFRDLIASFIRFRAATFRHRVNFCLLLDSISPHSTSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRY5</accession>
    <name>F9XRY5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_97978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847024.1">
        <property type="nucleotide sequence ID" value="XM_003846976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRY5"/>
    <dbReference type="GeneID" id="13399419"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97978"/>
    <dbReference type="HOGENOM" id="CLU_731975_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRY5"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391877" evidence="3">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="378" mass="41262" checksum="D86BE85B8170E14A" modified="2011-10-19" version="1">MFFPSSSLKFSLLPVAFSFALDVQCPNTDSSPAQPKIAFLVKHRPTHDPHKVVLLLEVFRLGSKVTISLSIRLTSATLFLQSSSLCSFLRVPSSEFIVNMDSPSSKSASLIGGEMSKAGWDRLRATRACWTAVCLFFSTVICLFFSAVICLFFSAVICLFFSAVICLFSSTVICLFFSGAVCLPFLSDVGLSFAGLPFAGDPATVVCKTEVALNRVGRSDEGRHCREVFGEAYGDVSETATKTSTDPMEMTAFTSVLTADYQQHLKRLQGIRELLTAKRGLSAAEPGRRLASENQSGDKTEEERHEGKSLVKAERDVAPLILRTTSLSAGNRIPKPPTQDDFAFSRKPAADQVRILDGRWNIVKPSTLATISEDDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS27</accession>
    <name>F9XS27_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846919.1">
        <property type="nucleotide sequence ID" value="XM_003846871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS27"/>
    <dbReference type="GeneID" id="13396764"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98016"/>
    <dbReference type="HOGENOM" id="CLU_1950516_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS27"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391881" description="Secreted protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14375" checksum="F7A3D3EDC6A431E7" modified="2011-10-19" version="1">MHQKSAPVDFHRMLFIAYLHLLTSLRANHPISCPELPTRAVQTIEPRVCERHRPGTAGEAEESKESSAQVKKIRHVTGRRGGGRDWKDDSRYAAKGSVAAIRVLDDLPYTNGTGFTSPSVYASRRVLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS30</accession>
    <name>F9XS30_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846921.1">
        <property type="nucleotide sequence ID" value="XM_003846873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS30"/>
    <dbReference type="GeneID" id="13396709"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98019"/>
    <dbReference type="HOGENOM" id="CLU_1058474_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS30"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="263" mass="30439" checksum="1B120936E1A4CAA4" modified="2011-10-19" version="1">MCRLERKLGPPVRSTACAFGPRPVGREVRRRCVAFDPFISSRQLVPELPMYMPKRPSGQLSAATNETSGSTFYHIILDADDDITPAKKQPIRWRRQGPEGVAMLSRILEPQVLAPLREPRDSPCCQTRSLSSSEENSRRASKCKAIVVKSHLSGDIPSHFRCCGFSISSSVWLVVDLITSRFRKSKSREERERDRPRFLPAHVRVQETYERAVDCCVQWWRTWWRTWWRDDMRGSDEGFDCISDSDSVLRKVTLKEHNTWHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS90</accession>
    <name>F9XS90_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846904.1">
        <property type="nucleotide sequence ID" value="XM_003846856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS90"/>
    <dbReference type="STRING" id="336722.F9XS90"/>
    <dbReference type="GeneID" id="13396663"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98079"/>
    <dbReference type="eggNOG" id="ENOG502T46G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074456_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS90"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="259" mass="29098" checksum="63644EA3621BE520" modified="2011-10-19" version="1">MPAVTGKVYFSSVDHSSWVEAKLEFARFAVVKIATARMPWPQDSADDRPVGCPHRLQVDSAHSFIISMQPVPSALQTTLTHVSRSDGRELAFNQTKLINGVYHVTFDEDEAHGIITVNMVTRHPRNNFTAVHNFGNPMLHLKTYEKATTDVSKVVTKEVAVIKHAASTFSLARQPAGHAPHKQGPRTCVLNVAFTRVVSTVRSRNADTAREGMFHLRSFGTDTTREGRRVERKVDRRAERRTEDANSFSHNRRRSSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSA2</accession>
    <name>F9XSA2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846896.1">
        <property type="nucleotide sequence ID" value="XM_003846848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSA2"/>
    <dbReference type="GeneID" id="13396661"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98092"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_21.30"/>
    <dbReference type="eggNOG" id="ENOG502RDM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1483135_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSA2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="182" mass="19463" checksum="5EF5254DA5671FB1" modified="2011-10-19" version="1">MAVVYGGSGTGGDDDPDRRRLPPNPPPPLPPPDLPEDEYDIGFRKCRKCGQNKTLAHFRYGKGQHSFVRDCFACRNIIADAEGNVSLANRPSVSDRGRTAARKDLPSVEAIVRAECSLQQTLGPPHYDVSAGRGQQLAPNPLTRQTSGSTGFAPGPLAGSKRTALDLAGPSKLRRRGAEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5H8</accession>
    <name>A9Y5H8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 2</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nad2</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="13"/>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648749.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5H8"/>
    <dbReference type="STRING" id="336722.A9Y5H8"/>
    <dbReference type="GeneID" id="5846265"/>
    <dbReference type="InParanoid" id="A9Y5H8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002747243" description="NADH-ubiquinone oxidoreductase chain 2" evidence="11">
        <location>
            <begin position="17"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="12">
        <location>
            <begin position="145"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABU40265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="580" mass="64840" checksum="62A547C598A54F57" modified="2008-02-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW35</accession>
    <name>F9WW35_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_102083</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855965.1">
        <property type="nucleotide sequence ID" value="XM_003855917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW35"/>
    <dbReference type="FunCoup" id="F9WW35">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WW35"/>
    <dbReference type="GeneID" id="13403253"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102083"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.291"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="F9WW35"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="537" mass="59216" checksum="65B581C96F6B0FFF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW54</accession>
    <name>F9WW54_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_31465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857674.1">
        <property type="nucleotide sequence ID" value="XM_003857626.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK10426.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5003395399" evidence="3">
        <location>
            <begin position="25"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="349"/>
            <end position="632"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="766" mass="84515" checksum="8FB0D5F3D71732B3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWB4</accession>
    <name>F9WWB4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="EGP92537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857513.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9WWB4"/>
    <dbReference type="GeneID" id="13394338"/>
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    <dbReference type="eggNOG" id="KOG1591">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_4_1"/>
    <dbReference type="InParanoid" id="F9WWB4"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="231"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="244" mass="27412" checksum="DC5FB08662AFFFBF" modified="2011-10-19" version="1">MPKAKSKGSPKVENLVYTSRDLVCPPSNYDTHIYSTAPLLIYIENFLSNSEADHLISLSSDIWQPSTVSNNGALTHDPKVRLSEKAAIPRDRTVQCIESRALSFQGWPRDTFIEKLWTQRYNVSGHYALHYDWSSANPNARRVSSFMVYLEDGCEGGGTRFPKLKGRGDEKWCKFVDCGADEEGVTFKPKKGAAVFWRNFDDEGRGYKETVHAGMPVTKGTKIGLNVWSWYQAGHKAPDDVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX18</accession>
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        <recommendedName>
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    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_90056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856998.1">
        <property type="nucleotide sequence ID" value="XM_003856950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX18"/>
    <dbReference type="GeneID" id="13398100"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90056"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1797"/>
    <dbReference type="HOGENOM" id="CLU_1476268_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX18"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389736" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="17173" checksum="CA3A41480C41E84D" modified="2011-10-19" version="1">MRTTFATFGLAALAAAQVPESYSGSFPPTSAAAPATSAPATAGGDVLTLSYGPASSSMASMSSAMSAMSSPAVSGSASVDPILTSVSVPAMMNGTTTTIPCSAAACTDTAATDAPVAPVTTKSACPPKNGTAPAATAPATDAPTGSGPAATPSGGDDAPVYTGAAVKAGVSGLLLFGAAMFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX27</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MYCGRDRAFT_90067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856992.1">
        <property type="nucleotide sequence ID" value="XM_003856944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX27"/>
    <dbReference type="STRING" id="336722.F9WX27"/>
    <dbReference type="GeneID" id="13398703"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90067"/>
    <dbReference type="eggNOG" id="ENOG502TB88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746409_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX27"/>
    <dbReference type="OrthoDB" id="3884299at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="371" mass="42674" checksum="ADB66D729C72F37C" modified="2011-10-19" version="1">MRIKTTTPLAAGDSLTVKTLANQIQANHAAFDIRQHEHNQCTPGHPQDLITHPINYLRPVLHMQDPALNSAIRLYLHFVDHALPIFHSLLHCMPTLAARKDDSDVKEWTFPEPLVTLTAEQKAITWEYMGRVGREIEWKECSREEMNKGGKKMVAEGECTLRPDRPLQFCGLLGFGSTITTSRELVQQVEASARTGDSRKHQWCSFDLATTWLHELSHAVEHAVLPGVGWDDVFLGPGAKTSETGFEVEGRVLGGRFNVRNGNVGLPRADTGEVWMREWPDLMTIHEYWNDDNRLIARLPATELERLWVKQWRIDWRFVEKMFEDQFWQKHLKARLRQVAEKEKARQESLANGYVAREIDEYLANLNVRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX89</accession>
    <name>F9WX89_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SURF4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_67588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856879.1">
        <property type="nucleotide sequence ID" value="XM_003856831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX89"/>
    <dbReference type="FunCoup" id="F9WX89">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WX89"/>
    <dbReference type="GeneID" id="13398514"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67588"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2046"/>
    <dbReference type="eggNOG" id="KOG3998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX89"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP91855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34052" checksum="D44345661E724261" modified="2011-10-19" version="1">MAQIRGTAGYHLGNQSSASFGGPSNSSATNDPSPLDAIRRQTSKIEDLLDTWSDPVKPYLPAIGRFLIVVTFIEDAIRILTQWGDQLEYLHQYRHMPWGVNHVFLLVNVVAMVSSSLLVIIRKYSEYAVCGLIGVVVTQALGYGLIFDLNFFLRNLSVMGGLIMVLSDSWVRKKFAPAGLPQLDEKDRKMYFQLAGRVLLIFLFIGFVFAGEWSLGRVLVIIPGAIACVMVAVGFKAKWSAIVLVMILSVFNILVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQVSFDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXK7</accession>
    <name>F9WXK7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_98177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <sequence length="2365" mass="273445" checksum="21CC323A1AFCA4BB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXW7</accession>
    <name>F9WXW7_ZYMTI</name>
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        <name evidence="9" type="ORF">MYCGRDRAFT_65946</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="54"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="558" mass="61041" checksum="5E5AA35A0D633A3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ50</accession>
    <name>F9WZ50_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_66030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856264.1">
        <property type="nucleotide sequence ID" value="XM_003856216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ50"/>
    <dbReference type="SMR" id="F9WZ50"/>
    <dbReference type="FunCoup" id="F9WZ50">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ50"/>
    <dbReference type="GeneID" id="13402963"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66030"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.922"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156007_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZ50"/>
    <dbReference type="OMA" id="QWAIERN"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="103" mass="11489" checksum="3773384AF0308DA4" modified="2011-10-19" version="1">MRVSQILRSSGGDPKPGVYLGPWGALGSMPQKGVVHYGLAPNRQKPLAGVANAAVFNTFRRTRNQILFWSVPLIIAYELMEWATERNHYLNSKAGRAEYADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZP2</accession>
    <name>F9WZP2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_65129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857695.1">
        <property type="nucleotide sequence ID" value="XM_003857647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZP2"/>
    <dbReference type="GeneID" id="13403888"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65129"/>
    <dbReference type="eggNOG" id="ENOG502RXKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011915_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZP2"/>
    <dbReference type="OMA" id="QTPHIPR"/>
    <dbReference type="OrthoDB" id="5376052at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="736" mass="82935" checksum="82236F1FDC714005" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZY4</accession>
    <name>F9WZY4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_89175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857492.1">
        <property type="nucleotide sequence ID" value="XM_003857444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZY4"/>
    <dbReference type="STRING" id="336722.F9WZY4"/>
    <dbReference type="GeneID" id="13394491"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89175"/>
    <dbReference type="eggNOG" id="KOG4814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001453_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZY4"/>
    <dbReference type="OMA" id="KLSRWIR"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="109957" checksum="9201F7066B72604A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X059</accession>
    <name>F9X059_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857352.1">
        <property type="nucleotide sequence ID" value="XM_003857304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X059"/>
    <dbReference type="STRING" id="336722.F9X059"/>
    <dbReference type="GeneID" id="13394794"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107234"/>
    <dbReference type="eggNOG" id="ENOG502SIJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017507_1_0_1"/>
    <dbReference type="InParanoid" id="F9X059"/>
    <dbReference type="OMA" id="FCRPMRR"/>
    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55833" checksum="9843F2F965517DC0" modified="2011-10-19" version="1">MELSAAPNANHWSARLVTKLGGKLRSEKHYSQDAAEKKRRKDSSKLQKRGHQRPAVPEVNELGEQEYAIFAENRRPARRKEQDLGEMMHGLAYHDDEEDVPVEEKPADSHFSTDKRRRRRGYMVSQPHERRVASLPDELWKTIAFYLNPAEACQLALSSQTLYSKLGVYPFERLNLPSNKNHKIAFLHQFDSQLPNHLLCFPCRKYHLRLNPGKEVLKMDYINNPIFHCPNVKSSVLPRTRLTYARTLPYSFVQLALRSHHFSPAHGIDPDSLSRRWKCKDSGWTHATRYTINDDRLLLRVVSQRFAPPASSLSETAERHLLYDREEYVPFFSVCAHWRDGDLMKICKCMLSHIPAPPDPYRKQLQRGFVLDRAAAKPDFIVRGCDDCRPARRCPECPTEYMVEARLMEDEKDRENPFKHAIVVTRWTDLGDGMNPYTSPEWTAINGTNTNTGGEDGDAVYDSFTNVGRRAVGGIFESLPSADYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X068</accession>
    <name>F9X068_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_83794</name>
    </gene>
    <organism evidence="12 13">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856317.1">
        <property type="nucleotide sequence ID" value="XM_003856269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X068"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="13394798"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83794"/>
    <dbReference type="eggNOG" id="ENOG502QZ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="F9X068"/>
    <dbReference type="OMA" id="EQITPIC"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
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            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856557.1">
        <property type="nucleotide sequence ID" value="XM_003856509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0F2"/>
    <dbReference type="FunCoup" id="F9X0F2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="13395266"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98719"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1502"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="F9X0F2"/>
    <dbReference type="OMA" id="WFESFAI"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="132"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="585" mass="65047" checksum="CA04574EBE249F8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0W5</accession>
    <name>F9X0W5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FRE ferric reductase-like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_65806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857460.1">
        <property type="nucleotide sequence ID" value="XM_003857412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0W5"/>
    <dbReference type="FunCoup" id="F9X0W5">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="GeneID" id="13403031"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65806"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0W5"/>
    <dbReference type="OMA" id="IRITIQH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="254"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="12">
        <location>
            <begin position="381"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP92436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="528" mass="59934" checksum="743AC6BAE1E44005" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Y4</accession>
    <name>F9X0Y4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_65843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856199.1">
        <property type="nucleotide sequence ID" value="XM_003856151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Y4"/>
    <dbReference type="FunCoup" id="F9X0Y4">
        <property type="interactions" value="1085"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0Y4"/>
    <dbReference type="GeneID" id="13394604"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65843"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.797"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="InParanoid" id="F9X0Y4"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="107"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="590" mass="65665" checksum="92928CD6FADD46F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X151</accession>
    <name>F9X151_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_98638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856457.1">
        <property type="nucleotide sequence ID" value="XM_003856409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X151"/>
    <dbReference type="FunCoup" id="F9X151">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X151"/>
    <dbReference type="GeneID" id="13395090"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98638"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1318"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="InParanoid" id="F9X151"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP91433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="30489" checksum="D6B548C6E663FE13" modified="2011-10-19" version="1">MSSKRGGRGGGNRGPLPRNVQVSKKISWLLRHGAEKEGLQLGPGGFIGVQDVLSNRNLRSLKVTFDELRAIVQDNEKQRFTMVLKSSIDPNGAVLEDEDPTDIPTQTPLPSEDPKDYLIRANQGHSLKVESEGLLKPITPETAPKNVVHGTTHSAWPLIVASGGLKPMGRNHAHFASGLPAGFKSLVEEDSAATDAAPVISGMRKSSTVLMFLDIAKAMEAGVNFWLSDNGVILSEGNENGVIPLEVFRRVEDRTGEGVLLEDGMIVKEAPEKWSAKRNDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X193</accession>
    <name>F9X193_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MYCGRDRAFT_66684</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="18"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856478.1">
        <property type="nucleotide sequence ID" value="XM_003856430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X193"/>
    <dbReference type="FunCoup" id="F9X193">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X193"/>
    <dbReference type="GeneID" id="13395111"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66684"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1361"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="InParanoid" id="F9X193"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="18">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="22209" checksum="2553156371FF902A" modified="2011-10-19" version="1">MPSLLSYIDYSKPSLFVAAASILFNPTFWNLAARNEYRNKTLTKIFGGNPYYGCYALAVTIFSLGIFRDVLYERALRDQPTHPSLVGFPAKAAAVGLVASGNVLVLSSMWALGVTGTYLGDYFGILMDNMVTGFPFDVTGSPMYYGSTLSFLGTALWFGKPAGLVLTGLVLVVYQIALSFEDPFTAEIYAKREREQKAGKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X213</accession>
    <name>F9X213_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_79179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855804.1">
        <property type="nucleotide sequence ID" value="XM_003855756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X213"/>
    <dbReference type="GeneID" id="13403744"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_79179"/>
    <dbReference type="HOGENOM" id="CLU_2489573_0_0_1"/>
    <dbReference type="InParanoid" id="F9X213"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="94" mass="10544" checksum="3DE421B8867021E9" modified="2011-10-19" version="1" fragment="single">KKKKKRQSTLSYTRISSKSEPKSHLVHFKELEQSVESTTLRLTCVAVCVGSSIQFHKGILRTREDSELDSCFCTAFALLLHSNLQRVCEAEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2C4</accession>
    <name>F9X2C4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_90715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855572.1">
        <property type="nucleotide sequence ID" value="XM_003855524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2C4"/>
    <dbReference type="GeneID" id="13403512"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90715"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.536"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_0_1_1"/>
    <dbReference type="InParanoid" id="F9X2C4"/>
    <dbReference type="OMA" id="VHKKYDR"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="88"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="32522" checksum="4082F3A9006715DD" modified="2011-10-19" version="1">MFASIKNKLKSSSSSAGNSSMKQSSNSHPQNNSTPSTRRPAPVRTQDMDDAPPPAYSPPANAAATSQIPSIAVTQVADDPYAFLGSFDTIFLVDDSGSMVGSRWHETAEALETITPICTAHDADGIDIFFLNHPDSAFHHNITQSSIVREIFQTVRPSGGTPTGQRLNQILKPYLRRVQANPDATKPINIICITDGEPSDDVESPLIAAAKKLDKIDAPAWQVGVQFFQVGRDETAKRHLQQLDDELAEISGDDELRDIVDTVPFMGSEGARLSGEGILKVVLGAVNRRLDRKKAKGLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2E1</accession>
    <name>F9X2E1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855013.1">
        <property type="nucleotide sequence ID" value="XM_003854965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2E1"/>
    <dbReference type="GeneID" id="13399804"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103310"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.721"/>
    <dbReference type="eggNOG" id="ENOG502SQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1741824_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2E1"/>
    <dbReference type="OMA" id="VGHHKDK"/>
    <dbReference type="OrthoDB" id="3923202at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="14415" checksum="3810EF64ACCAB558" modified="2011-10-19" version="1">MSVCPVVGTTTNVLPPHHPAVSSDPEAVCPVTNAKVKDHNTIVNHPSAPHIPSDDSSAMDASSCPALKNANAGESVTDATCPVVGPVNAHLPPSHPALNEKDAGAVCPITNAKLEHHKGKVANHPTVANDAAAKQCPVVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2Y7</accession>
    <name>F9X2Y7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_15092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854944.1">
        <property type="nucleotide sequence ID" value="XM_003854896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Y7"/>
    <dbReference type="GeneID" id="13399584"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15092"/>
    <dbReference type="eggNOG" id="ENOG502SJ2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="F9X2Y7"/>
    <dbReference type="OMA" id="FCEIFYT"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="102"/>
        </location>
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            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
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            <end position="184"/>
        </location>
    </feature>
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            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29483" checksum="1DB1E529452A5DAB" modified="2011-10-19" version="1" fragment="single">ATLAVNITFFALTWITVSLRVLVRAGMLRAFGSDDWTMLITQLLFTAYLIVQLGGVYYGTGEHLSDLVPWRAERALQYWYFCEIFYVLSTCLLKISVSLFLLRVATHRLHIFIIHTIMVVSALLGFTFFFVLIFQCYPVSDWWSLDPLQKHCINPTVVIGLTYAVSGLNVIADWTLGILPIFVVRELDMSKRQKRLVAGILSFAAVGSTATIVRLPYIGSLKESFLGSNGNFLYNTVGVAIWTTVEVGIGISAGCLATLRPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2Z2</accession>
    <name>F9X2Z2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_108070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2Z2"/>
    <dbReference type="STRING" id="336722.F9X2Z2"/>
    <dbReference type="GeneID" id="13403482"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108070"/>
    <dbReference type="eggNOG" id="KOG3053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026793_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2Z2"/>
    <dbReference type="OMA" id="DFDLWPP"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="604" mass="66399" checksum="2F66D5B06EF55185" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X334</accession>
    <name>F9X334_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_108173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855439.1">
        <property type="nucleotide sequence ID" value="XM_003855391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X334"/>
    <dbReference type="FunCoup" id="F9X334">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X334"/>
    <dbReference type="GeneID" id="13399839"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108173"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.809"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_0_0_1"/>
    <dbReference type="InParanoid" id="F9X334"/>
    <dbReference type="OMA" id="PISWGNV"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X369</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D1"/>
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    <dbReference type="GeneID" id="13395939"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35631"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.146"/>
    <dbReference type="eggNOG" id="ENOG502SHYG">
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    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38228" checksum="09B664843176026B" modified="2011-10-19" version="1">MGAAILNQSRVQGHKTDNLPKELIRNARSTPRTAFNASKHLSYIPPSKISTFADIDQPSTGISDTAVSEPFLLFSPEAIQQMRAEAFSEEVLEHHYSPTSETGGMIRGHCPGRAPFIYDAWTSPELLKIVSEIAGVDLVPAMEYDIGHVNVSVSNDSADTSLETAAQDEVEDSKNSKRFKTPYDYHRDCFPFVVVTMLSDCTDMIGGETAIRTESGKVIMARGPSLGTAVVMQARYIDHKATVARGGKERISMITSFRPRDINMKDESDLSGVKIVSHIPTLYYQYSSYRLENLEARVREQCRLIRRRQRANADFDVKQLRSWVETQKAYLDTLLNEIQEV</sequence>
</entry>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854870.1">
        <property type="nucleotide sequence ID" value="XM_003854822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3K6"/>
    <dbReference type="GeneID" id="13399359"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68113"/>
    <dbReference type="eggNOG" id="ENOG502S145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108920_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3K6"/>
    <dbReference type="OMA" id="GWNEAKG"/>
    <dbReference type="OrthoDB" id="2586183at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="194" mass="21694" checksum="150EF7875092697D" modified="2011-10-19" version="1" fragment="single">MSTAIHWPDRYTPGTTDNYVSNEVIAKDVTAAQIWALLADITKWETYYWNCTEITPPKSGPKLEEGNDFQFSTFGFPPLPCTIRESVAPSASQPGRIAWEAVTDGEGGKTIYVYHAWIVEDLPGGRVRILTQESQIGDVFKDFAGKKPNPMLNGHQDWLDGLVKAARGEKPDEPGAWSRFYRRNVDDDLTIATD</sequence>
</entry>
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    <accession>F9X3P6</accession>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3P6"/>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="348" mass="38739" checksum="58884ABB75333DEF" modified="2011-10-19" version="1">MPSTKRLFDETDVQRTPKKRRTLTPPTTPPTPTRTHPMRTRLSTLTITRAAVLSTPELLTLILSHLPALHLLHSARLVSSTWHQLITTTSPTLRAATYLSSPRPKKREWYVFDQITSHLALFRSGDEVLLQYQLGYLAAKQWAERQLSSRPTEINALILRRTEQGGMLRPLAERAMVCEGLSLLSPFEAGLSKDKAEGWIGLLKTDGVWSRMLVSQPPVRVVEAWVHYDVVPKKGTTSMALRSGLSSAPERKVWDFTRSGRGAGRERKPTGKMHIHVERRDGQGVTVGDVMGEIVKKARVLQGKDDAEVEVRSGSGKWGSIVWLLGAVFVSEEEKKGMEGRRIGGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Z3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855159.1">
        <property type="nucleotide sequence ID" value="XM_003855111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Z3"/>
    <dbReference type="FunCoup" id="F9X3Z3">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3Z3"/>
    <dbReference type="GeneID" id="13400704"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69026"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1071"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3Z3"/>
    <dbReference type="OMA" id="PYATVWA"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="19004" checksum="7A698F062164C016" modified="2011-10-19" version="1">MIIYKDLITDDELISDSYDLKEIDGIVYEADCKKITIGDDNIDIGANPSAEEADEGTESNAQTVLDVVHSFRLNETQFDKKQYLSHLKTYMKKVKEAMKANGASDETVAEFEKGASGFAKKVIGNFKDYEFLIGENMDPDGMVVLLNYREDGVTPYVTVWKHGLKEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X431</accession>
    <name>F9X431_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TPI1</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_55968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855291.1">
        <property type="nucleotide sequence ID" value="XM_003855243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X431"/>
    <dbReference type="FunCoup" id="F9X431">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X431"/>
    <dbReference type="GeneID" id="13400273"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_55968"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1118"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="InParanoid" id="F9X431"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="248" mass="27043" checksum="2BB0C0DC2DD95023" modified="2011-10-19" version="1">MARQFFVGGNFKMNGTISGIKDIIHHLNDAKLDPNTEVVVSPPALYLLLAREHLRSGIEVAAQNVFDKPNGAFTGEISVSQLKDSNITWAILGHSERRTIIKESDDFIASKTKTALDGGLGVILCCGETLEQREANKTKEVVLSQLAAVSKVTQDWKNIVVAYEPVWAIGTGKVASEEQAEEVHKWIREWIEKELGKEAAEKTRIIYGGSVNEKNASSLAKQSNIDGFLVGGASLKPAFVEIINAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X458</accession>
    <name>F9X458_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_54822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855739.1">
        <property type="nucleotide sequence ID" value="XM_003855691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X458"/>
    <dbReference type="STRING" id="336722.F9X458"/>
    <dbReference type="GeneID" id="13395976"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54822"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.207"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="F9X458"/>
    <dbReference type="OMA" id="ERISQYY"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="258"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP90715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="44919" checksum="3826FA1BDF33E594" modified="2011-10-19" version="1">MADDKGLDDIDAAEIESTCDETTDSFDAMNLSTDLLRGIYAYGFERPSALQQRAIMPIVRGKDVVAQARSGSGTTAALSISVLQSIDSTVKACQALIIAPTRERAQRIQKVLSTIGDFTNVECYACVGGTRIGDDITALQDGLQSVVVGTPGRVLDMIHRGALCTDNIKMTVLDEADEILSRGFDEQIRDIFGILRQSTTTQVVLFSATMPQDVLEVISEFMRDPVRITVEKYETCLKGSKQFYLTVETDQEDWKVDRLSDLHKTIITNRQTVIFCNTRKKVEWLTDKLTARDIPVSAIHRDMDAWQRADILQHFFSGSHILVATNMIAKSIDVQQVPLVINYDLPSDPEDYIRRVGRGGGGRRGRKGVAVNLVSGDELRAMHEIEQFYSTEIEKMPTNAADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4K4</accession>
    <name>F9X4K4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_37366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855401.1">
        <property type="nucleotide sequence ID" value="XM_003855353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4K4"/>
    <dbReference type="STRING" id="336722.F9X4K4"/>
    <dbReference type="GeneID" id="13400027"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37366"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143697_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4K4"/>
    <dbReference type="OMA" id="CEQAISE"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000043">
        <property type="entry name" value="Helix-loop-helix DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="154" mass="16880" checksum="212F0A389446F243" modified="2011-10-19" version="1">MGGGPGVSNGEGSPTDGGPQAPGSSSKPQVGTDEWHKIRKDNHKEVERRRRETINEGINELAKIVPGCEKNKGSILARAVQFITQLKENETQNIEKWTLEKLLSEQAITELGTSCDKLKAECQRAWAECEQWKKAAQKAGVTIDHDEKGEGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5K6</accession>
    <name>F9X5K6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_38178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854538.1">
        <property type="nucleotide sequence ID" value="XM_003854490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5K6"/>
    <dbReference type="STRING" id="336722.F9X5K6"/>
    <dbReference type="GeneID" id="13404062"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38178"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="F9X5K6"/>
    <dbReference type="OMA" id="DIWQYHN"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="WSC" evidence="14">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="884" mass="96057" checksum="58D0282E26520791" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5M8</accession>
    <name>F9X5M8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MgEXG10</name>
        <name evidence="24" type="ORF">MYCGRDRAFT_38087</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853845.1">
        <property type="nucleotide sequence ID" value="XM_003853797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5M8"/>
    <dbReference type="STRING" id="336722.F9X5M8"/>
    <dbReference type="GeneID" id="13404184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38087"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_2_1_1"/>
    <dbReference type="InParanoid" id="F9X5M8"/>
    <dbReference type="OMA" id="WVWITET"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390143" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGP88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="271" mass="29598" checksum="46453707CBF0FF68" modified="2011-10-19" version="1">MRFSAVITALAASAPLTTAFYRGFNMAGNNEDGSCKTTAQWTEAFNKLKGLPQPITSVRLFASSDCNTLDNAVPAALNTGTKLLVGLWTQNEDHFTAEKHALESNIKAHGSDWILACAAGSEDIYRGGLDINRLAEQIYDVRGMIRALGSNAPVGHVDTWNAWVNPGTDVVTKACDFVGMDAYPYWQGARIEDAHDVFMKTLKDTRDHVNSVKNGIPVWVTETGWPVSGPNFGASVASKTNAQKFWRGTGCKLFNQGQSFRVAIYIVFRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5Q1</accession>
    <name>F9X5Q1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_15247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854397.1">
        <property type="nucleotide sequence ID" value="XM_003854349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Q1"/>
    <dbReference type="STRING" id="336722.F9X5Q1"/>
    <dbReference type="GeneID" id="13395583"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15247"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="InParanoid" id="F9X5Q1"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="349" mass="38569" checksum="63B90A4B9E51DF68" modified="2011-10-19" version="1" fragment="single">DTSLSVQLHPLVLLTISDYITRHTLRQQNGPIVGAVIGQQNGRSFTLEHAFECKVSAQDGEVKLDQEWFSDRIEMYKDVHKAPALELVALFALGPVDGPQPAHLPMLRQVRQLLSSDSIMLLLFHPEMVDSLQGGKLPISLFESVEEIEADQLQLRFRELQYEVETGDAEMIGVDFVAKGGGTATAVRKAEIHSPTTSGSKEKKGKGKGKAKEEDGDTNETTSTHHLSAEDDELISSLNAKVNAIKMLNERLDLIRSYLTSLPPSYLTDSTLKDMPENANYTLLRSVNSMLSRLPLLTSPKSDSQAASNQKEKQDVHLTSLLANLTRSVAEAQSLSSKFHVVQRERANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8F9</accession>
    <name>F9X8F9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_20852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853014.1">
        <property type="nucleotide sequence ID" value="XM_003852966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8F9"/>
    <dbReference type="GeneID" id="13397335"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_20852"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002903_1_0_1"/>
    <dbReference type="InParanoid" id="F9X8F9"/>
    <dbReference type="OMA" id="QITWTSH"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF76">
        <property type="entry name" value="POLYAMINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65515" checksum="8377E99CFBE4AD91" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8N8</accession>
    <name>F9X8N8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MYCGRDRAFT_41254</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853232.1">
        <property type="nucleotide sequence ID" value="XM_003853184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8N8"/>
    <dbReference type="FunCoup" id="F9X8N8">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8N8"/>
    <dbReference type="GeneID" id="13399509"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41254"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="InParanoid" id="F9X8N8"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="273"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGP88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="548" mass="61098" checksum="52F46F04CEC11F5A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Q2</accession>
    <name>F9X9Q2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_104239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853335.1">
        <property type="nucleotide sequence ID" value="XM_003853287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Q2"/>
    <dbReference type="GeneID" id="13399285"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104239"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.595"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9Q2"/>
    <dbReference type="OMA" id="FTKVDVT"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31351" checksum="B4362EA0348212E4" modified="2011-10-19" version="1">MADRDSLTSRTLPFITLSDGSLASKTGPPPPLPHYLNAEGRALARFAVEGNVVITGGAGTLGLSAARALLEHGASGIALWDLESTLRTSQTSILALAKDFPKTRVFSIGVDVTDVEGIAEAVTTVVKTLGSLDHLFCFAGIVGCVHSMEMTEAQWRKTLDVNTTGSFLCAQAAAKQIASQDNGGSITFIASISGHRVNFPQAQVAYNVSKAAIISLKSSLAAEWAVHGIRVNSISPGYMDTILNAGEGSIAEARDVWAARNPMGRMGAVGELDGMCVLLASRAGSYINGSDLVIDGGQIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA05</accession>
    <name>F9XA05_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaminase A L-glutamine amidohydrolase</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GLS-A2</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_71401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853093.1">
        <property type="nucleotide sequence ID" value="XM_003853045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA05"/>
    <dbReference type="STRING" id="336722.F9XA05"/>
    <dbReference type="GeneID" id="13399987"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71401"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="InParanoid" id="F9XA05"/>
    <dbReference type="OMA" id="WTGYLVR"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391217" evidence="1">
        <location>
            <begin position="20"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="353"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="536"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="691"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="808" mass="89855" checksum="B39F73DBBD536B8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA41</accession>
    <name>F9XA41_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_109248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853293.1">
        <property type="nucleotide sequence ID" value="XM_003853245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA41"/>
    <dbReference type="GeneID" id="13399316"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109248"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.677"/>
    <dbReference type="eggNOG" id="ENOG502SY3U">
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    </dbReference>
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    <dbReference type="OMA" id="EHANERF"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="487"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="726" mass="82017" checksum="BFBA6DE31AFEA739" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAU2</accession>
    <name>F9XAU2_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93035"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391508" description="Hydrophobin" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="13909" checksum="77A9A16EBDED1E71" modified="2011-10-19" version="1">MFNDYCTATISLLLALLAATGTLATFTCPKPVNPIANSPSNACCKELSDLRVKLGGFSLYYGKSCYKATISQVTGPKTAVTEDCPEDMQAGCCDPVCGPAIPFEVVCGAESWDAQTLLELTGSAPCTGPNSNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAY7</accession>
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        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
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        <name evidence="14" type="ORF">MYCGRDRAFT_23946</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0715">
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    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR018253">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="416"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
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    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="464"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="464" mass="48533" checksum="6080FCB7B849C83E" modified="2011-10-19" version="1" fragment="single">FHATARSLATKDPYAALGISKSASAGEIKKAYYGLAKKYHPDTNKDPTAKEKFADAQSAYEILSDSKKKEMYDQYGAAAFDQGAGGPGGAGPGGPFGGGNPFGGGGFGGFGGGASGGGGFGADFNFEDLFSAFGGSGARRGRRGGPFQEEVMVGENIEVQTNISFMDAAKGVEKEITITPLVQCKTCTGNGLKKGMSRSACKTCDGTGQRVHFMQGGFQMASTCGSCGGTGVTIPRGGECGTCRGEGAVREKKTVTVDIPGGVEDGMRLRVMGEGDYPPTGQAANASARSQKGDLYVFIRVAPDSKFSRSGSDVLYTASIPLTTAVLGGEIKIPTLDGDVKVKVATGTGTGDKITMPGMGMKRLGARRGQQGDLKVEFKVQMPKYLSVNQRTIVEMLADEMDDKSAKRIMNLNNLKHAPKASTTDKGTPDDHKNEGLLKNLWHSVTGQHDHLDKAEEGKKAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBB5</accession>
    <name>F9XBB5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_71881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852703.1">
        <property type="nucleotide sequence ID" value="XM_003852655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBB5"/>
    <dbReference type="GeneID" id="13397026"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71881"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.211"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBB5"/>
    <dbReference type="OMA" id="HIHDGRG"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="285" mass="31185" checksum="BE726C27F304EF48" modified="2011-10-19" version="1">MTSKKIRIVCISDTHNRAPGEGYTLPQGDILIHAGDLTNQGSYKELKKAVDWISFADFAVKIIIAGNHDLSLDSNYSLKHESGWKVLPEDVKACRGLMRSDQFIYLEHSSAMVHLPEKDVTLRVFGSPYSPDRGRQNWAFQYENSVAATLWDQVPQDTDILITHTPPKGFCDESRHWEQGGCAALAKTLPRIKPLVHVCGHCHEGRGARIVDWGDACTTSSPAARVWSDASAGTKKVSKLDLSELIAGRETAVVNASIMGTSHGHGGKVYNKPIVVELRVAASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBQ3</accession>
    <name>F9XBQ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MYCGRDRAFT_100176</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852150.1">
        <property type="nucleotide sequence ID" value="XM_003852102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBQ3"/>
    <dbReference type="FunCoup" id="F9XBQ3">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBQ3"/>
    <dbReference type="GeneID" id="13393926"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100176"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.283"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="F9XBQ3"/>
    <dbReference type="OMA" id="PVQKDCD"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGP87126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116567" checksum="61D562574EEBFE94" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC05</accession>
    <name>F9XC05_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_72059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852651.1">
        <property type="nucleotide sequence ID" value="XM_003852603.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9XC05">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC05"/>
    <dbReference type="GeneID" id="13393951"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72059"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.335"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048451_1_0_1"/>
    <dbReference type="InParanoid" id="F9XC05"/>
    <dbReference type="OMA" id="CYGPGIT"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="331" mass="35785" checksum="AF9025AB0F00ED31" modified="2011-10-19" version="1">MFYDLNIPWSPTDQNLNKTLAFSQELGYNVVALNHTMSGKLPNDLTCAIPPLANPPPNLTVLRRLTLILTDSHQNAKLALLAKEYDLIALRPIDERTLQLACGSLDCDIISLDFSTRLPYFFKFKTLSEAIKLGKKFEICYGQGLSGDAQARRSVISNATQLIRASRGRGLIISSESRVGAAGLRGPWDVVNLAAVWGLGPERGVEAVGKECRSAVVTGKLKRSGYRGAVDVVYGGEKPARVEKEVEDKAKKQKGQQTQNQLKGQTGQHQQTGQKRKAEGDEAAGAEPPLSKRQAKKRAHEARMLAAAENGEGTAKVASGPSDAGATEHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC96</accession>
    <name>F9XC96_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_80821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852632.1">
        <property type="nucleotide sequence ID" value="XM_003852584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC96"/>
    <dbReference type="GeneID" id="13396954"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_80821"/>
    <dbReference type="eggNOG" id="ENOG502SWNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099493_2_0_1"/>
    <dbReference type="InParanoid" id="F9XC96"/>
    <dbReference type="OMA" id="VPQNHFT"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="16664" checksum="DD289D8135F3C999" modified="2011-10-19" version="1">MSNSVNDDYYDGNWWWSDTGYAIRYTIIIVILAIILLYFVGGYFHARRRMKKGLPLKRYHRWMVRRQYRQQQHAAPQYNAYYQDPNQQGYPMQPYGNNPPPPYVAPPPAYAPPEGASKAMADQNYTHLAQAGGPSGPPPPAAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCB8</accession>
    <name>F9XCB8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_104520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852202.1">
        <property type="nucleotide sequence ID" value="XM_003852154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCB8"/>
    <dbReference type="FunCoup" id="F9XCB8">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCB8"/>
    <dbReference type="GeneID" id="13393978"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104520"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.396"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="InParanoid" id="F9XCB8"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="99" mass="11276" checksum="473C30559930DE7D" modified="2011-10-19" version="1">MGDRRGGGQRKVLLPPINFIFKLLQQHSTVQIWLYEQLGIRIEGKIRGFDEFMNLVIDEAVEVKQPGKGQTEADVKDQRRELGQILLKGDNVCLIQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCI5</accession>
    <name>F9XCI5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852612.1">
        <property type="nucleotide sequence ID" value="XM_003852564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCI5"/>
    <dbReference type="GeneID" id="13396934"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93251"/>
    <dbReference type="eggNOG" id="ENOG502RG71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533413_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCI5"/>
    <dbReference type="OMA" id="QFVVHMP"/>
    <dbReference type="OrthoDB" id="5415055at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="511" mass="55081" checksum="71813D9A46223DAB" modified="2011-10-19" version="1">MTTTRPEPIRMKDSDDYITARHANPKTGAISPSLGPRTPGSNLSTFTPASPGEALKLRSLGQESPTANARDRHAYSRANESRNLSGAHIKHSVEPQTWHYNTVGQARGGAAVPYVRRDVKRKDIPHSPHPPEPDKLVHMPSAEEPQPFAYPGYSSEQIDALEHYRCKSPRVSSDGYDQRLLLKTKDVGVPHVCTCRTAEIEHCTNSDISSVCACPKYFRPYQGAPSQHAAGEVPPIKVRKRRGGSGGNYRVDAGRGPPPSGMPNGTVEEVTIISSPLATRNGKGQPSRTLPGAFPNCSAKTPCCELHAVSAKLLSSIDLAPRTKYGEHAPLHDQDVCRGASSELMQMLPPVDLVRPELAAVLGARDARRADYHRTNKSVGRSCSLGCQRDGSTGQCTGRRDTSQTSAAPEEQASLPKIPPQYLEQAEEFVISIITSILCYLRDIQLPKSDLAETLTSPTATVKEKAKALKAALSLAGHVLAIGMTLGILIIHNSLFSDSRASTDSIVSASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDT5</accession>
    <name>F9XDT5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_109947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851574.1">
        <property type="nucleotide sequence ID" value="XM_003851526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDT5"/>
    <dbReference type="FunCoup" id="F9XDT5">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="GeneID" id="13402133"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109947"/>
    <dbReference type="eggNOG" id="ENOG502QU5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021380_0_1_1"/>
    <dbReference type="InParanoid" id="F9XDT5"/>
    <dbReference type="OMA" id="DMNMDFL"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="539" mass="60774" checksum="A40CA1311F008BEC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDX3</accession>
    <name>F9XDX3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tho complex subunit 7/Mft1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_109969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851590.1">
        <property type="nucleotide sequence ID" value="XM_003851542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDX3"/>
    <dbReference type="STRING" id="336722.F9XDX3"/>
    <dbReference type="GeneID" id="13402035"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109969"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.554"/>
    <dbReference type="eggNOG" id="ENOG502S942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049078_1_0_1"/>
    <dbReference type="InParanoid" id="F9XDX3"/>
    <dbReference type="OMA" id="QFLHNAN"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37877" checksum="321A0857C98CBC0A" modified="2011-10-19" version="1">MADVELRPLPEQAQEDALHAARLLSVEERPFQRVTKTLLASNSLLRPSLTYLPSPPPEGEDDYDSSRVERFREDVLLDFANLESSITRIQLILSSNQRERERYAAEKAKILETAQAVRDNTVELRAHLVEAQAVLERRKGYDLMATKILDDTKLKSRDDARADIEKLEKEIANLQDESAEYEVTWVSRREQFDNIVREGEAMVRAIKGIKDDPEPEKDENMEDAEDDGEDGVKANTSRMNSPGADGRSPRPADTGNATPMVESGEGGGATPARPTNRLLDVDEATRSSSRTGSPLAQPVQMPDDVDMTEGGTAESRPSTAHGLEASADQAGTPMADVAESMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE94</accession>
    <name>F9XE94_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MgBGL4</name>
        <name evidence="21" type="ORF">MYCGRDRAFT_44498</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851635.1">
        <property type="nucleotide sequence ID" value="XM_003851587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE94"/>
    <dbReference type="STRING" id="336722.F9XE94"/>
    <dbReference type="GeneID" id="13401998"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44498"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.640"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="F9XE94"/>
    <dbReference type="OMA" id="YERGYAM"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390446" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="20"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="733"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGP86611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="821" mass="88403" checksum="BCFDBF267BC539BE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEB2</accession>
    <name>F9XEB2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA J-class molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSP</name>
        <name evidence="10" type="ORF">MYCGRDRAFT_100391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851989.1">
        <property type="nucleotide sequence ID" value="XM_003851941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEB2"/>
    <dbReference type="SMR" id="F9XEB2"/>
    <dbReference type="FunCoup" id="F9XEB2">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEB2"/>
    <dbReference type="GeneID" id="13401231"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100391"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.42"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="InParanoid" id="F9XEB2"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395477" evidence="7">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="425" mass="47694" checksum="54578390B4D1CFF4" modified="2011-10-19" version="1">MLLFSVLALVCLLPLLALAAEDYYTLLGVDKSASERDLKKSYRRLSKKYHPDKNPNNETAAKKFVEVSEAYETLSDKELRRIYDAHGAEGVKQHKERGAGGGGGRNPFDMFSQFFGGGGHFHGSGQRRGPNMELRVDTPLRDFYTGADHEFSVEKQVICEKCEGSGSADGERDTCGKCRGQGMVIQKQQLMPGIYQQVQMQCDACGGKGSTVRHKCPHCHGERVLRSQEQFDLSVEKGMPRGARVAYENEGDESPDWAAGDLLVSIHEQTPKVADDEKHRTDGTFFRRKDRNLFWREVLSLREAWMGDWTRNLTHLDGHVVQLSRKQGEVVQPGTVDVIPGEGMPVWKGGGEQYEERARASGAVEKDDGYLYGALHVEYVVVLPDQMDSGMEKEFRSTWDKWRKKSGVDLHKDSGRPAPVMHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEH3</accession>
    <name>F9XEH3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_100614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851648.1">
        <property type="nucleotide sequence ID" value="XM_003851600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEH3"/>
    <dbReference type="GeneID" id="13401859"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100614"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_0_1"/>
    <dbReference type="InParanoid" id="F9XEH3"/>
    <dbReference type="OMA" id="SYFMVAQ"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="45"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="273" mass="28885" checksum="A973636354BA32E4" modified="2011-10-19" version="1">MDKGSNNNNTPSSSSSISSSLASATASAPASYPTSNSSTSGGKRGLAYNDASLTTCFADSSEITWAYNWGSSRDGLSSNLKFIPTLWGDRQDFTSVWDANVQTAIADGAEYVFSFNEPDHDGQACMAPSDAAAAYKKYMNPLKGQAKLCAPSVTNGGGSMGLGWLQSFLDSCGGECAVDCLNVHWYDAASNSAYFKQHVQQAIDMAGGKPVFVSEFGATGSDEEISAFLEEVMAWMDGNKDVAGYAYFMVKDGDLVTGTEPSAYGNTYKTYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XET8</accession>
    <name>F9XET8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850850.1">
        <property type="nucleotide sequence ID" value="XM_003850802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XET8"/>
    <dbReference type="GeneID" id="13397588"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94722"/>
    <dbReference type="HOGENOM" id="CLU_639694_0_0_1"/>
    <dbReference type="InParanoid" id="F9XET8"/>
    <dbReference type="OrthoDB" id="10390909at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="429" mass="47644" checksum="5456BFAC7B7DDD40" modified="2011-10-19" version="1">MSISSNQIRSADSKRLLTPNECQGTVAKQQLGAETGRTTLQGPSKKSSGIMAQNEVTTVVTVKRPVFRIFDLPAELRSNIYEQFVDDRSISVPLVFGVINLVLRQQQDFALPTVPQGLLAAMPEWARSAGAMVVEVNLKAPRFSTPFLPVRRTKEIDQVHVKRPEASEVEKQIGLSDLREAMGFYLGVWEIEQGVWEFHDLDLNTIENEQTGNAVVDSATGAGEASIAAGQTGFDFPALPPELRNVLYELQVRPPTTVIKLYPPRATDSPTPAPALAFASHEIGRESMPLLYQNVALVLRPQPDFVVVTFPRSLLRAMPSFARYVNTLEVEFVFRAPRLETTGNGTVLDFQMKFEMDSKKGFKITASAHDPMTEYDRAKILKSAENMAKEVKALLLGYLNQDSVLMKQLVEAEGGLVFTWTKWVNPYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFB6</accession>
    <name>F9XFB6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_31156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851214.1">
        <property type="nucleotide sequence ID" value="XM_003851166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFB6"/>
    <dbReference type="STRING" id="336722.F9XFB6"/>
    <dbReference type="GeneID" id="13397389"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31156"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2999132_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFB6"/>
    <dbReference type="OMA" id="IANWDGM"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="53" mass="6077" checksum="0938C898C709DC20" modified="2011-10-19" version="1" fragment="single">VKLDHLGPMVVNKDGTLSRIGNWDQMTEQEKKNTLRILGKRNKQRTSALKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFK7</accession>
    <name>F9XFK7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851192.1">
        <property type="nucleotide sequence ID" value="XM_003851144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFK7"/>
    <dbReference type="STRING" id="336722.F9XFK7"/>
    <dbReference type="GeneID" id="13397408"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28493"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_6_3_1"/>
    <dbReference type="InParanoid" id="F9XFK7"/>
    <dbReference type="OMA" id="NPGHYEQ"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="140" mass="15639" checksum="E533C7FF43BF1EE2" modified="2011-10-19" version="1" fragment="single">ASISTSTPNMSKSSFQDEVLNSTNYYRKQFQVEPVTWNDTLADFADDYVKGCIWKHSGGPYGENLASGYETTALAIDAWGDEEHLYNWAKQKFSEGAGHFTQLVWSNTTTVGCGVVNCTEEGKGNVQGRYLICEYWPRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFU2</accession>
    <name>F9XFU2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_86865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850712.1">
        <property type="nucleotide sequence ID" value="XM_003850664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFU2"/>
    <dbReference type="STRING" id="336722.F9XFU2"/>
    <dbReference type="GeneID" id="13397889"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86865"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="InParanoid" id="F9XFU2"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="118"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="345" mass="39710" checksum="AE84BD6033997298" modified="2011-10-19" version="1">MEDPATTPKDNPEKRSDPFQFGTRYLEDGDDIFAHNAWDHVEVDAQYTEFIEQQTQFQKENQVSDFDKKRFNDQPEKWWNKFYSNNQANFFKDRKWLFQEFPVLAEVTKEGYGPVTVLEVGAGAGNTAFPVLALNHNPELRLHACDYSKKAIDVIRSQPAYLEQTGSILHADVWDAASSTELPPGLTEGTVDVIVMIFIFSALSPDQWTQAVANAWNLLKPGGEVLFRDYGRGDLAQVRFKKGRYLDENFYVRGDGTRVYFFDQQELRHIWGGVDKAGDAAASTEKESSYGTESSHRFEILNLAVDRRMLVNRQRKLKMYRCWMQGHFRKPGSQKLVKEDHEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG55</accession>
    <name>F9XG55_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851083.1">
        <property type="nucleotide sequence ID" value="XM_003851035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG55"/>
    <dbReference type="STRING" id="336722.F9XG55"/>
    <dbReference type="GeneID" id="13397823"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94580"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.476"/>
    <dbReference type="eggNOG" id="ENOG502TA53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307602_0_0_1"/>
    <dbReference type="InParanoid" id="F9XG55"/>
    <dbReference type="OrthoDB" id="3639531at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="961" mass="105226" checksum="85B64B851F272825" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG65</accession>
    <name>F9XG65_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_105021</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851317.1">
        <property type="nucleotide sequence ID" value="XM_003851269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG65"/>
    <dbReference type="GeneID" id="13395301"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105021"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.6"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="F9XG65"/>
    <dbReference type="OMA" id="SDNYAFW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="386" mass="42782" checksum="F55161BE56A982AC" modified="2011-10-19" version="1">MSTAKSPLARYRQLAPNASVRVSPLCLGAMTFGESGRQINGFTTLAETNAILDAFYNAGGNFIDTANGYQAGESERRLGDWMAAKGNRDEMVIATKFTAGYMGAEPDRIQVNFSGTGSKSMKLSLDASLKKLQTHYVDILYLHVWDSSTSIPELMHSLNDLILAGKVLYLAISDTPAWIVSKANQYARDHGLRPFVLYQGLWNAGKRDFERDIIPMARDEGMGLAPWGPIGEGRFKTKDVLEKLEKGNRGLAITQRDRDVSAVLERVAEKKGRTMYQIAIAYLMHKTTYVFPIVGSTKAEHLQSNIEALTIELTKEEMEEIEGAYPFDHGFPHTFLSGSHFEGEDAKPRQVEGPQDVMFNAANIDWVKGPQPIVPGQEEQAKTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG70</accession>
    <name>F9XG70_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_25122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851314.1">
        <property type="nucleotide sequence ID" value="XM_003851266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG70"/>
    <dbReference type="STRING" id="336722.F9XG70"/>
    <dbReference type="GeneID" id="13395303"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25122"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="F9XG70"/>
    <dbReference type="OMA" id="MLNASMP"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="326" mass="36938" checksum="4466329CB58ECCC4" modified="2011-10-19" version="1" fragment="single">QLANSYQSLLSEFSSPEFHTVGNYALGRLIGKGSFGKVYLASHKLTNGSKVVLKSAKKDDANLAREIHHHRQFSHPHIARLHEVIVTETLVWLVLEYCPGDELYNHIHKNGRMEVGKAQKVFTQLVGAVNYVHAKGCVHRDLKLENILLDKNENVKLVDFGFTREYKGSTSYLQTWCGTVCYSAPEMLKGEKYAGEKVDVWSLGIILYALLCGELPYDEDDESDTKNKILKEEPKYPDHMPEQAKDLIKKLLSKRPLLRPSLGDILRDPFLYDHAPQQQEILKLQQPPPFTTQLEKDVLQRMKSAGVNIDTVIENVLSQRCDSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGH4</accession>
    <name>F9XGH4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_44913</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850585.1">
        <property type="nucleotide sequence ID" value="XM_003850537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGH4"/>
    <dbReference type="FunCoup" id="F9XGH4">
        <property type="interactions" value="1421"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGH4"/>
    <dbReference type="GeneID" id="13401121"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44913"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="InParanoid" id="F9XGH4"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="80"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP85561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="451" mass="50044" checksum="CAD575DBF2818BC2" modified="2011-10-19" version="1">MTPSAISIFNQNEYHECHELSLKNGSFDTSASDSEYGANCPDGQKSAKGLIGAALQKHIDNVDPHECEAGAEDAFFVADLGEVYRQHMRWKKHLPRVTPHYAVKCNPDPAVLKLLAKLGAGFDCASKTEIEQVLGMGVDTSRIIYAQPCKTKSYLRYTSKQGVKQMTFDNTDELYKIKDIYPEAELFLRIFTDDSASLCRLSQKFGASMDNVQELLALAKELELNVVGVAFHVGSGASDPSAFRQAVTDARTVFDQAAELGFTLHTLDCGGGFISDTFDDMASVLAEAVDDLFPPSVRIIAEPGRYYTSSAFTLACNVIARRTVQDKQSLVNTDTSYMLYMNDGVYGNFSSIIFDHQHPIPRVLRTARRADGFNYSRKAITYSIWGPTCDGIDCIAEKWFAQDVVDVGDWLYFEEMGAYTKCSATRFNGFTDRHEVVYVCSEKGARDLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH00</accession>
    <name>F9XH00_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_101080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850255.1">
        <property type="nucleotide sequence ID" value="XM_003850207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH00"/>
    <dbReference type="GeneID" id="13394430"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101080"/>
    <dbReference type="HOGENOM" id="CLU_2308305_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH00"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="11594" checksum="E066255057E4C5D4" modified="2011-10-19" version="1">MSIEMIFASAVRLPHIPHPPRPLPIDCGTEGTITRLKMTLTPLRMSFAHPSKLSTRRIHMLNVFKCCRKRILRLEVVKLSPFVIFQIPQEHRLKSIIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH66</accession>
    <name>F9XH66_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein LOT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_110395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849977.1">
        <property type="nucleotide sequence ID" value="XM_003849929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH66"/>
    <dbReference type="GeneID" id="13402771"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110395"/>
    <dbReference type="eggNOG" id="ENOG502S43V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054062_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH66"/>
    <dbReference type="OMA" id="NMHEYFD"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="30758" checksum="C44FBDA61FDD779E" modified="2011-10-19" version="1">MAVEPLDTAPALGDFTLLNEYTSQTPGTFFGGLPVLHLHAPSATIKLQSSDAASHPDFAALADPSTVSASSDGPLHIPSIDIWITSRALLLWSTTHSKGLTIPYPVITVTAQDRTEVLLELNLSAPDASDEDLDFLQLRLIANEVSHHAAATADAGGANGTEEQASAKKVFRAISDCQELNPDPPAQGEDGEEEGGFDPTAPGATGWITSENMADFMDENGEFKMPEGMAVIGGEEDEEESAEGAQQNGLGEGAGRRRTAAEIDGGDAEQGAEGVPHSVESHRSASIPVAFYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHK2</accession>
    <name>F9XHK2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_61546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850406.1">
        <property type="nucleotide sequence ID" value="XM_003850358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHK2"/>
    <dbReference type="STRING" id="336722.F9XHK2"/>
    <dbReference type="GeneID" id="13402815"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_61546"/>
    <dbReference type="eggNOG" id="ENOG502S8IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="InParanoid" id="F9XHK2"/>
    <dbReference type="OMA" id="ETWILRP"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="161" mass="18315" checksum="890CAA05BE6296FE" modified="2011-10-19" version="1" fragment="single">MKIVLTGSTGFIGSEILKQCIAHTFISHIYVLTRRPLDNRFSHKKVTQLLHEEFETYSPELLDRLREEGVEACIWSLGGSVQQFKDLDEARRVGVNYPVAAAEAFAGHLATALEPHTGFPEKSPAAGEKRFPFRFVFISGWGAEVDQFRRLWMYADSRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHY1</accession>
    <name>F9XHY1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_105489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850357.1">
        <property type="nucleotide sequence ID" value="XM_003850309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHY1"/>
    <dbReference type="STRING" id="336722.F9XHY1"/>
    <dbReference type="GeneID" id="13394860"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105489"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_11_0_1"/>
    <dbReference type="InParanoid" id="F9XHY1"/>
    <dbReference type="OMA" id="HIFQEKH"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="412" mass="46748" checksum="9259606FABD14BDA" modified="2011-10-19" version="1">MPQFQQKQQQKRVFDDQRTGSIRNADYFTNTGNVASGSIVDEKRNDDDTSDEVVKPAAETFEQINRWTFFSSEIDETIHAPELGGLLMPGETFRDLFELSPDGGVWWLDMLNPSEEEIFAICSAFRVHPLTREDITTQETREKVELFKSYYFLCFRSFYAVDKESEDYLEPINIYAVVFREGLLTFSFCQNHHAATVRKRIGRLRDYVNLSADWVCYALIDEIVDSFGPVLEELERETDTIEDSVFTARFEDSRVMLKQIGECRKKIMALSRLLGGKADVIKSFAKKCNESYTVAPRGDVGLYLSDVQDHIVTMMSNLGHFEKMLSRSHTNHLTQITLQHTEQGSRANELLGKITIIATILVPMNLVAGLFGMNVHVPGEGVDGYGWWFGIVGVVLTLAVVSVTAAKKFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI42</accession>
    <name>F9XI42_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_29061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849899.1">
        <property type="nucleotide sequence ID" value="XM_003849851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI42"/>
    <dbReference type="GeneID" id="13402694"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29061"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_3_1"/>
    <dbReference type="InParanoid" id="F9XI42"/>
    <dbReference type="OMA" id="GGYKGSW"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="150" mass="16264" checksum="E788C8FD74A57FAB" modified="2011-10-19" version="1" fragment="single">SPSKKDPSKPSPKTSIPPAVSRPETQSDLAHHLHRIQSSSTLTPFRKQTLSLLLQIPPGQYSTYGALAAHISATSHKTCARAVGSSMRNNPFAPEVPCHRILAGDGSLGGFGGDWGEEGRHAGEKRRLLREEGVRFDEKGKVKGPVFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI96</accession>
    <name>F9XI96_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_74909</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850324.1">
        <property type="nucleotide sequence ID" value="XM_003850276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI96"/>
    <dbReference type="FunCoup" id="F9XI96">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XI96"/>
    <dbReference type="GeneID" id="13394752"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74909"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="F9XI96"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="165" mass="18696" checksum="D8116109B64EAB20" modified="2011-10-19" version="1">MNSMAAKRLFQEYKGLSVEPPIGITAGPVNEDDLFVWEAMIEGPEGTPFEGGVFPAELKFPRDYPLMPPTMRFLCDIWHPNVYPNGTVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMIAEPNDESPANIDAAKMWRERRKEYEARVKADVRRSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XID0</accession>
    <name>F9XID0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_46635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849915.1">
        <property type="nucleotide sequence ID" value="XM_003849867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XID0"/>
    <dbReference type="FunCoup" id="F9XID0">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XID0"/>
    <dbReference type="GeneID" id="13395153"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46635"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="InParanoid" id="F9XID0"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17279" checksum="54AA6FED1FD7115C" modified="2011-10-19" version="1">MPAIRTAKNRKPPPEGFEDIEDTLLEFANKMKDAENASHEGKKKHEMLWPVFQITHQRSKYIYDLYYEKEAISRPLYDWLLKNNYADANLIAKWKKQGYEKLCCLRCIQTKETNFNSTCICRVPKEKLSEDQEIQCVSCGCRGCSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIQ8</accession>
    <name>F9XIQ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NFA2402</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_101069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850137.1">
        <property type="nucleotide sequence ID" value="XM_003850089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIQ8"/>
    <dbReference type="FunCoup" id="F9XIQ8">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIQ8"/>
    <dbReference type="GeneID" id="13394698"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101069"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038163_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIQ8"/>
    <dbReference type="OMA" id="RFTFEFK"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="309" mass="34591" checksum="B569FB00EB99F19D" modified="2011-10-19" version="1">MAEESPISYEDLANIEEDFEEVDTEIVRQQYALSAPLYAKRSTTVSQIPNFWPLVLEQAPPELDSFISASDSQIFGESLLALNVTRPELENGAAGHPRSLKIDFTFKPNDFFEDTELSKTFSYRRAKDGWTGLVSEPVKIHWKKGKDLSEGLNDNAVALFEARKKAGNMLARDIPEYKKLQEKLESLNGANTSFFTFFGWRKAGERVEVPEVSEEDEEAADDSEVEVHEAGEQVAVTIAEDLWPNAIKFFTQAQELGEMSDVDFEEDDDEEESGEDEPVDIRALVGGKDKGKAAKRLSDSGPPSKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJA2</accession>
    <name>F9XJA2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_110793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849441.1">
        <property type="nucleotide sequence ID" value="XM_003849393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJA2"/>
    <dbReference type="STRING" id="336722.F9XJA2"/>
    <dbReference type="GeneID" id="13402236"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110793"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.396"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="InParanoid" id="F9XJA2"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84417.1"/>
        </source>
    </evidence>
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                <person name="Ben M'barek S."/>
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849530.1">
        <property type="nucleotide sequence ID" value="XM_003849482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKD6"/>
    <dbReference type="GeneID" id="13402325"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95952"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.574"/>
    <dbReference type="HOGENOM" id="CLU_667651_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKD6"/>
    <dbReference type="OrthoDB" id="10340163at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="412" mass="44592" checksum="819CD8917ECEF2FD" modified="2011-10-19" version="1">MTDQDADYQAYLQSFGYNPQSPPANETPMQPFTDEQFAQCVKDLTGLEFSPLPTEQHAGISNQHDPMHNQSSANILPDEQMIDPRLGHNDAGEAHAQPSNGSVLTYNTGRFEDVLPEDDLSWVLRTPPPYTVPACPDIPELIEAANSAVEQNTGPGHESLNDLSQCSICGWLFDVHAPGCGVEATQHLIDAVLGGSTDAGQVLIDEFMDGQVEVQTRGTKRRRESSSPPSASKPTQQTAESSTARPIKRMKAPHTFAGPLIPAPATGIYTNKFHSTADARGYLVNGSRSADHSGNASKIHKYATMVMDACLATLPVSSANAHQNQISEAVHNALRLAPSRVEAQVYVFTMGFLDRVTGNTNWVAKGIRPEETQPVIRLVQRLMVDKSLALDVVTGRAEKDLIGLMKAMRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKH7</accession>
    <name>F9XKH7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MgLAC1</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_75961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849549.1">
        <property type="nucleotide sequence ID" value="XM_003849501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKH7"/>
    <dbReference type="SMR" id="F9XKH7"/>
    <dbReference type="STRING" id="336722.F9XKH7"/>
    <dbReference type="GeneID" id="13402355"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75961"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="InParanoid" id="F9XKH7"/>
    <dbReference type="OMA" id="NEYSGAC"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="368"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="992" mass="108705" checksum="B2DAE80C97FC216A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKV0</accession>
    <name>F9XKV0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848990.1">
        <property type="nucleotide sequence ID" value="XM_003848942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKV0"/>
    <dbReference type="GeneID" id="13398310"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96417"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.529"/>
    <dbReference type="HOGENOM" id="CLU_473434_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKV0"/>
    <dbReference type="OrthoDB" id="10401227at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="576" mass="63283" checksum="7CA87A9448B1F9E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX0</accession>
    <name>F9XKX0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_87907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849000.1">
        <property type="nucleotide sequence ID" value="XM_003848952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX0"/>
    <dbReference type="GeneID" id="13398320"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87907"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="F9XKX0"/>
    <dbReference type="OMA" id="MIACCTW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="523" mass="57735" checksum="DB354AD8E89C75CD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL49</accession>
    <name>F9XL49_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849121.1">
        <property type="nucleotide sequence ID" value="XM_003849073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL49"/>
    <dbReference type="GeneID" id="13398593"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96234"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704393_0_0_1"/>
    <dbReference type="InParanoid" id="F9XL49"/>
    <dbReference type="OMA" id="WIESMPD"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395672" description="GST N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="392" mass="43753" checksum="0F8FD6BDA6632F4F" modified="2011-10-19" version="1">MKLFTILLAVLPAALAVAVADPAPQGGICCNYCQKGSQCAKNCVICRLCKLIIDVVEERNERERQELTTARNDIKKILPTAIAIMGSISNDPVILFGYPFSPYVQKIALLLHVTEVPFKFQEVGPLIPRPELESIGITYRRVPILAVGKDIYCDSKVQQRVILERLAKKQIPTSIHDRAWEEWGFVAFDQTLGLAPGKLMTPEFAKDRGSIYPLLIRPDFDTLRESAVADLHSRLDYLENTVLKETKYIGGNEITLATIHAIWGVRWDLHGLEDQPPGLGETHPAVGKSRFPKVHGLIDSLPLPEFKHISFDEAKEQIFASRYTSEITGLLKDEPTEIQVGTLVTADSLGSEPRKHPVHGKLHATDGYEFVLEVPTGLRIHFPRESTILRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLC5</accession>
    <name>F9XLC5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_87717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849188.1">
        <property type="nucleotide sequence ID" value="XM_003849140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLC5"/>
    <dbReference type="STRING" id="336722.F9XLC5"/>
    <dbReference type="GeneID" id="13396639"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87717"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.147"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="F9XLC5"/>
    <dbReference type="OMA" id="VGMIWAG"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="40299" checksum="95A71DAB6509EDCE" modified="2011-10-19" version="1">MTTYNIASIPGDGIGTEITEAAEAILLKLASVVGTFNFNFTTFDWSSKAYLERGWYMPEDGMQQLAKHDAIYFGAVGWPSVPDHISLWNLILPIRKYNNQYVNVRPTRILPGTTAPLAQCQKRPQDLDWVIIRENSEGEYAGQGGTTHDNSPHTVATEVAIFTRVGIERIVRFAFETAKSRPRKLLTMVTKSNAQRHGMVLWDKVFYEVAKEYEGIVKHDKMLVDAMTVRMVNKPESLDTIVATNLHADILSDLAAALAGSIGIAPSSNVDPTRQYPSMFEPIHGSAPDIAGQGIANPVGAFWSAAEMVRWLGKGELDQVADDLMQAIENVTSNPETRTKDMGGSASTQQVTDALLKQIEVVFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLL7</accession>
    <name>F9XLL7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_25695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848825.1">
        <property type="nucleotide sequence ID" value="XM_003848777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLL7"/>
    <dbReference type="FunCoup" id="F9XLL7">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLL7"/>
    <dbReference type="GeneID" id="13398641"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25695"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_1_1_1"/>
    <dbReference type="InParanoid" id="F9XLL7"/>
    <dbReference type="OMA" id="WRIYEAN"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <sequence length="233" mass="26713" checksum="6A3C1EB077A300CF" modified="2011-10-19" version="1" fragment="single">SNDAGEIRRQVEFYFSDSNLPCDAFLLAETGGHANKPIPIKTIHNFKRMRHFQPFSAVVDAIKGSDFLEVNDKDEVFRKEPLDSKFTDDPKENDKLLTSVSMGRSIYAKGFGEETDSSAFDIEEFFSPYGVRSVRLRRQQDGTFKGSVFVEFQDEAAATQFLEMEEKPKYNDKELLTMSKRQYVDTKVNAIHEGTVQPRSPKQWGNNRENRRGGDRGGRGRGRGDRRDRGDRR</sequence>
</entry>
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502ST5Y">
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            <end position="677"/>
        </location>
    </feature>
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        <location>
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            <end position="626"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="746" mass="84860" checksum="FE6D723863CF9ECB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP83675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="625" mass="68502" checksum="C774F985D738B35B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Aminotrans_3"/>
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        <property type="entry name" value="Aminotrans_3_PPA_site"/>
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        <property type="entry name" value="DTB_synth_BioD"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="791" mass="86912" checksum="79CF5F4A6953CB12" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNC7</accession>
    <name>F9XNC7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_29525</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848561.1">
        <property type="nucleotide sequence ID" value="XM_003848513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNC7"/>
    <dbReference type="STRING" id="336722.F9XNC7"/>
    <dbReference type="GeneID" id="13396424"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29525"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_2_1"/>
    <dbReference type="InParanoid" id="F9XNC7"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="83" mass="9952" checksum="ABFC9BA7591108CE" modified="2011-10-19" version="1" fragment="single">LYRRALKLSLDWAVHRYVWRGQAMYIRSLFEANRTVNQPRQQKMLVEQTEELLEKWKHPDPYRPPTAPGGSKYERNLPCPNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNL1</accession>
    <name>F9XNL1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_77354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848173.1">
        <property type="nucleotide sequence ID" value="XM_003848125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNL1"/>
    <dbReference type="FunCoup" id="F9XNL1">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNL1"/>
    <dbReference type="GeneID" id="13401606"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77354"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="F9XNL1"/>
    <dbReference type="OMA" id="DPHSLQM"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="25445" checksum="79D26C05F8CF8D55" modified="2011-10-19" version="1">MSPKVLFVLSSHDQMGNTGKPTGWYLPEFAHPYYKLEGKADITIVSPAGGKAPLDPSSVEMFKEDAESQKFLKEKSALWENTEKLSDYIGKASQFDAIFYVGGHGPMFDLATDEKSHQLIREFYEAGKVVSAVCHGPAALAKVKLSDGSYLVNGAEVTGFSNTEEDQVQLSSVMPFMLEDELKKNGGKYVKADEPWGAKVVSSGNHGKLLTGRGTILTGQNPNSAGPIGEAILKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP57</accession>
    <name>F9XP57_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_101803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848076.1">
        <property type="nucleotide sequence ID" value="XM_003848028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP57"/>
    <dbReference type="FunCoup" id="F9XP57">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP57"/>
    <dbReference type="GeneID" id="13402093"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101803"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.372"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="InParanoid" id="F9XP57"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="52345" checksum="6049799ECC930E86" modified="2011-10-19" version="1">MASANDAPAAGKLWGGRFTGGTDPIMVQYNESIYFDRAFYSQDIRGSIAYARANKNGGLLTDHEFAEIERGFGLVMKEWQDNKFEIQPGVDEDIHTANERRLGEIIGKEIAGKLHTGRSRNDQVATDMRLWLRDQLDNLEGFLVAFLKVIAARAEKDIEHVMPGYTHLQRAQPIRWSHWMLLYGSFFASDLERLREVKARVNRSPLGCGALAGNPFNIDRDAIAKELGFDGLIMNSMAGVGDRDFVVEFMQWGTMLMTHLSRWAEDLIIYSTGEFAFVKLADTYSTGSSLMPQKKNPDSLELIRGKSGRAFGHMAGLMMSIKGIPSTYNKDLQESVEPMLDHVKTVGDSIQIATGVLSTLAINPENMIKSLSPDMLATDLADYLVRKGVPFRETHHISGRVVALSESEGKPMDTLTFEQLRSVDSRFEKDVLGVFDYQKSVEMRSAKGGTSRSAVMEQIEAVKKILAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPF9</accession>
    <name>F9XPF9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848232.1">
        <property type="nucleotide sequence ID" value="XM_003848184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPF9"/>
    <dbReference type="GeneID" id="13401820"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96903"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.40"/>
    <dbReference type="HOGENOM" id="CLU_1807734_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPF9"/>
    <dbReference type="OrthoDB" id="10434043at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="16387" checksum="6C8B9FA27112E687" modified="2011-10-19" version="1">MSKFCETCYEMGHMWWEGCPGLCFWCDEAFGHWTEKCRTGDDTKAQFEKAMAMTKKLAAVRGYGKRLARAVAKAEQEVEEEKKMRKEQGQQTFLVNGEDPFPGVHGKERRKMIKDLKWQQKRAALAGKAASERKDTDMNGANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPK8</accession>
    <name>F9XPK8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_88369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847508.1">
        <property type="nucleotide sequence ID" value="XM_003847460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPK8"/>
    <dbReference type="STRING" id="336722.F9XPK8"/>
    <dbReference type="GeneID" id="13401311"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88369"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.7"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="InParanoid" id="F9XPK8"/>
    <dbReference type="OMA" id="INRAMYM"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="429" mass="46801" checksum="B109AC7C1A714679" modified="2011-10-19" version="1">MEALANYGAKIMPEMISRTESVYIYTEDGRKILDWTSGQMASLLGHCHPEVVETIRSAAGKLDHVSSCMLAPPVVELAKRLTDALPSGLDKAVFFSTGSESNEAAIRLAKLYTGKFEVVALGQSWHGMSAEAQAAQYQGGRRGYGPSIPGQHMLPQPNAYRSPFRNRDGSYDWETELDYGWSLIDQSSCGSLAACLVECIQGDGGIHVLPPGYLKTIKQRCEARGMLLIVDEAQTGLGRTGKLFAIEHDDVVPDILTLSKPLANGLPLSAMVTSAEIDARGKEKGFLFFTTHTNEPLLAAVANTVLTVLVRDNLVQNAVARGEQLKNGFLKLKDRYACIGDVRGRGLMLGLEIVDDRRRKTGNPKLARALSEALWHKGVWCQLQAGAVFRIGPPITITSDQVSEGLRMMDEVFRSTTRTVVAQKTARSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPL0</accession>
    <name>F9XPL0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847509.1">
        <property type="nucleotide sequence ID" value="XM_003847461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPL0"/>
    <dbReference type="GeneID" id="13401310"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97246"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.9"/>
    <dbReference type="HOGENOM" id="CLU_1929242_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPL0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="131" mass="14272" checksum="0BFD36A6F7389096" modified="2011-10-19" version="1">MTQGSYREFEASVKHRGQLPKAVHACGRTYPCKGANQSRHYAPKSYESVTHKMASNVPSGTFTKAKVLVICLARQSNCSETKHLWTVSTAPGYAVSTITHHAEPCTLRDITKAAQEAHFGNLGAVWRGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ71</accession>
    <name>F9XQ71_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847611.1">
        <property type="nucleotide sequence ID" value="XM_003847563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ71"/>
    <dbReference type="GeneID" id="13401171"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97433"/>
    <dbReference type="HOGENOM" id="CLU_850493_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQ71"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="327" mass="36910" checksum="8BC7CF90F53806E0" modified="2011-10-19" version="1">MSFSAVYVKIIDSAVRSQHTDVAMRPQYSRGRRPAILIGFSIAFRTSASAMRCTPCTLSLPSQGRLIDPSMMKMRSWTILGSWRPMSNLLLSKTVVKSLASVSEKPPELLRKRGRRWTRDDEAHMVAEYRKGISIGDIASKLARTSQSVVGKLYQLGVPLRARRILPWTTEDLRIMEHSVSEGQSFAAIAKLLGRTELSVLAKHKTQGQVLGRFWTELEVEQLTELKRQQATIEDICAHFPHRSRRSLVVKAWRLGRRTPQTVAMAIPWSSEEAYLALKLRDRYKLSCRLVASLLGTKRSTDSVATKIYLLKRASTTDKEDGGLITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ96</accession>
    <name>F9XQ96_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_111686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847717.1">
        <property type="nucleotide sequence ID" value="XM_003847669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ96"/>
    <dbReference type="STRING" id="336722.F9XQ96"/>
    <dbReference type="GeneID" id="13401029"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111686"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_1_1_1"/>
    <dbReference type="InParanoid" id="F9XQ96"/>
    <dbReference type="OMA" id="IPCFMFA"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000382">
        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="514" mass="55664" checksum="56643A52AFE3D19D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQA4</accession>
    <name>F9XQA4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_16863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847715.1">
        <property type="nucleotide sequence ID" value="XM_003847667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQA4"/>
    <dbReference type="GeneID" id="13401034"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_16863"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="InParanoid" id="F9XQA4"/>
    <dbReference type="OMA" id="KNGFQIY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31638" checksum="E8595D14FEB5F568" modified="2011-10-19" version="1" fragment="single">HDVETILNFHKDNEDGSPPAPTYVGRPETYERPVDAHKVTIHDVTGDEDKYTLDSHGFQLVPSVSGEKDFLDDDVIKETYYKEIDQLLKDVTGATRTFIFDHTIRRPTPATASDPAQEDQTSPKLNLRGPVRRVHIDQSYSAALSRVPHHLPSEADHLLRGRVQIINVWRPIRTVLRDPLAVAQSQSVAEEDLVPIGLIYDTRKGETLSVKHAEGQKWFYKHHQTPEEVVLIKCFDNRAEDGVRAKRVPHSAFEVEGTEAKEERESIEVRCLVFHEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQL6</accession>
    <name>F9XQL6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847492.1">
        <property type="nucleotide sequence ID" value="XM_003847444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQL6"/>
    <dbReference type="GeneID" id="13400602"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106588"/>
    <dbReference type="HOGENOM" id="CLU_2742001_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQL6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391854" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8019" checksum="CB23A0E12C139B85" modified="2011-10-19" version="1">MTLIVKAGDILATPCRTRSWIAALAWFWINGFCAGQSIDLHDSPWSGCSSNVHQRQEHWRLRVLLLTGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQT3</accession>
    <name>F9XQT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_111740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847436.1">
        <property type="nucleotide sequence ID" value="XM_003847388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQT3"/>
    <dbReference type="GeneID" id="13400367"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111740"/>
    <dbReference type="HOGENOM" id="CLU_588228_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQT3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="465" mass="50526" checksum="5818BA44363709FB" modified="2011-10-19" version="1">MLLCILKRATTAPWYELYGKQFRRNLGLIDFNASSSSKSNPSEGLPPSPHIVPILRTQVLVPIVMPGFVSHVISDSQRPSALLPNRLTQLIGFGLACDEPPNGTSAESPFVSLFDEAFEDIESPFVYATGMAFDQLNSAVPHAQELQGLKERIRIQTEGIEKLTAEHGKVKEERRKLDIHLQEVLDSNDESLKRVDMLVQAGVTLPRWVMELAEELRNDKVQLQAELNAAYGKESDTDAVRQGELAAAGILPGLHSAFRRRMRKGSGEQSRCACTGRLLEFPIEGYMNSSKLKYLIIDEADRITNDFGHRISEFQANATFKIIAFSATSNSASEPRLPLAERRSDDSVGHCQELRGARSPALVSAAAVGVAWRQLTCSSSILLARVILGSRSSTAAVLEICRLVRDNKVVEMNGSQGMFITFPPGGDGGSAGSQGEGAAKQDDYVSSGVAATETADRNSIIGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR31</accession>
    <name>F9XR31_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001210">
        <property type="protein sequence ID" value="EGP82291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847315.1">
        <property type="nucleotide sequence ID" value="XM_003847267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR31"/>
    <dbReference type="GeneID" id="13400134"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97638"/>
    <dbReference type="HOGENOM" id="CLU_1062487_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR31"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="30408" checksum="CA72B24B6AC02EC3" modified="2011-10-19" version="1">MSGLREVSRKTTFEPAEHLRQNSLSTLAMKLRALEKTKDEKTKDKKNQGRAVCTQTFNIETPAPKSNTRTTKAVVCLRRHLIYREMKRAELSMLRHAISNKQASQRGKGSEQVGKQVAHRYDTLRVGRRFRLRPGRLRRRRYIIALAPFRLSSHALSSSRFKDQHAKCQVPKSGYAGINAEIDNDFYDYEFYHCQDDLKYGDDAYWGETDSLSSLYFLSSLYFRSRSESSGREVMADWQSKWLDYDSDFVLNKTFPKPPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRH1</accession>
    <name>F9XRH1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847159.1">
        <property type="nucleotide sequence ID" value="XM_003847111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRH1"/>
    <dbReference type="GeneID" id="13399662"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97821"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.53"/>
    <dbReference type="HOGENOM" id="CLU_2075013_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRH1"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="118" mass="13124" checksum="758C8DF6AE426789" modified="2011-10-19" version="1">MRKEDQRSAAEKEEEGDLSAGDSGQTDTSTTRNSGATTVVLTRLHHPGNHILSLTKATFTSLHLSVLLYVGHDWLQDCTASLASTEQRTPWHQSAANSILCHRSRKLLLNLPTRMMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRQ8</accession>
    <name>F9XRQ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001213">
        <property type="protein sequence ID" value="EGP82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847104.1">
        <property type="nucleotide sequence ID" value="XM_003847056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRQ8"/>
    <dbReference type="GeneID" id="13399456"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97903"/>
    <dbReference type="HOGENOM" id="CLU_1344189_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRQ8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="204" mass="22047" checksum="CD928298B8FB6491" modified="2011-10-19" version="1">MSSKDVSLGLAGGVEGSPEGITLRRDAVSIARTIRGNPSSLGYTRRDLVLIIIIIHLANPLGRPVGSPRSERLHSLRDPPKVTIVASRILGTENRARSSFAADADESPFHFCVVLVRFVPGVKDGLGDGFGDTHDAGHGVRVVGMFHLRLVKVQIFEEVYDAIGVGKPNRALAFDQPLFDQDTDRAGVRFGGFQSSRDIQHIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSC2</accession>
    <name>F9XSC2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846885.1">
        <property type="nucleotide sequence ID" value="XM_003846837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSC2"/>
    <dbReference type="GeneID" id="13396673"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98111"/>
    <dbReference type="HOGENOM" id="CLU_1579743_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSC2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="169" mass="18596" checksum="070082F0C8EAB717" modified="2011-10-19" version="1">MDTCAMYVDQNPDQGAYHLGRAVEESRFGPYMVGQSYNTAEELKAFLRRIDLDSNRQKKSEPAAAAGGNGGGGRARNNNNDKDKDKQPERSLPSSMNYGMTKAYDWSKIGQSYKPMTQSGWTACLRRMDASHARRRDTTVAALTARSSSTARSAATTTLSRTPRTQCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW49</accession>
    <name>F9WW49_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_17411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857677.1">
        <property type="nucleotide sequence ID" value="XM_003857629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW49"/>
    <dbReference type="GeneID" id="13403248"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17411"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022048_5_2_1"/>
    <dbReference type="InParanoid" id="F9WW49"/>
    <dbReference type="OMA" id="KCSHFYC"/>
    <dbReference type="OrthoDB" id="3650316at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP92653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17599" checksum="2D63DFC93B2141E2" modified="2011-10-19" version="1" fragment="single">AILPCGHPYCADCLTGVLRNSMTDGTAFPPRCCRQDIEIEEVRRHLEPAFAVEFDAKAIELSTVNPVYCSNAACSVFIPPAVVRGGDVALCPSCFTRTCTHCKAGSHPGDCQEDQGLQQLLQMAEGEGWRRCECGRVIELNFGCNHMTCQCRREFCYLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW58</accession>
    <name>F9WW58_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_98225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857671.1">
        <property type="nucleotide sequence ID" value="XM_003857623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW58"/>
    <dbReference type="STRING" id="336722.F9WW58"/>
    <dbReference type="GeneID" id="13403916"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98225"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="InParanoid" id="F9WW58"/>
    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="239"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP92647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="586" mass="66224" checksum="1F88085F005E2946" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWJ8</accession>
    <name>F9WWJ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856356.1">
        <property type="nucleotide sequence ID" value="XM_003856308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWJ8"/>
    <dbReference type="GeneID" id="13402887"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107284"/>
    <dbReference type="HOGENOM" id="CLU_1391225_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWJ8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="196" mass="21986" checksum="7097760A4DC45E8B" modified="2011-10-19" version="1">MQDPLNHRSVGTSRRDERFPAIPSHHQPAMIFRPGLSNESTPSTVVRLIVSTVDCLDIHDGFDWKRATIAYRRLRQDPKRQTTNRQHHELHKAIRSPITSNDFRSIPTVPYNSNLEHKLNSSPSQTLQLHDTRSSKAAQPHHQRQDEMKGNIVIAIIIIILFLVLGLIGFGIYWAQTRVGGARGGSSTGTGTSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWZ3</accession>
    <name>F9WWZ3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_67094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP91597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="13398845"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67094"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34537" checksum="AE2AACA2D4A06F76" modified="2011-10-19" version="1">MANQHPSDIWLAGAFAAFTVDLIVYPLDTLKTRLQSPLYLSTYRNASNTAFTPAMFRGVYQGVGSVILATLPASGTFFTVYEGVKGGLHGWNGVGGEAQSGGWLPTPVLHGIASGTAELVSCAILTPAEVIKQNAQMVDNSGKQRVNATLQTLQRFKSNPLALWRGYTALAGRNLPMTALQFPLFEGIKRRIYAYREEKGIRSHSLVESAVVTAVSAGVGGSGAAVVTTPIDVVKTRIMLAAAEEAREGVEKIVKPGRLTSWQIGKEVWRDEGLKGLFRGGALRGVWTMVGAALYLGCYESGRIYLAQRRGEEVDVEELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX00</accession>
    <name>F9WX00_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_67099</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67099"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="F9WX00"/>
    <dbReference type="OMA" id="DKVMGMT"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    </dbReference>
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        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="339" mass="36961" checksum="99BEE192FC05FDBD" modified="2011-10-19" version="1">MVKTRQWQLAHQPRDEPQLDGPEQTFKLKEVDLPELQDDELLIKITDLSNDPAQRGWIDPDLAESGRLYVPPVKVGAPMSARALAEVVESRSSDYKKGDVVIAAPGWTEMAVVKASAVQPAKDLPGNMSKTHYLGALGGTGLTAYFGLTEVGQAKKDDIVVISGAAGATGSMAVQIAKKIIGCKKVIGIAGTDEKCRWVEKLGADVCLNYKSSSFQEDFKKQTPTGDGFVDVYFDNVAGDILDLVLTRMASRGRVIACAGLKNWFEIVIMRVRVQGFIVLDYMKDFPRALDELRQALEDGKLEIEGGETVVSGSFEDVPKTWLKLFSGSNQGKLVTHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXM9</accession>
    <name>F9WXM9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_52203</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857652.1">
        <property type="nucleotide sequence ID" value="XM_003857604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXM9"/>
    <dbReference type="GeneID" id="13403942"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_52203"/>
    <dbReference type="eggNOG" id="ENOG502SBBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084522_1_0_1"/>
    <dbReference type="InParanoid" id="F9WXM9"/>
    <dbReference type="OMA" id="ECYGIFQ"/>
    <dbReference type="OrthoDB" id="3632646at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF2">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19777" checksum="B475844C77FEB5A2" modified="2011-10-19" version="1">MPHQDPEIYHTTPTPHCPNSTLPVLVYRNVLPSPITVDSITEFFAQNEWHRGGVFKHYPTAHFHSNTHECYAVLSGETECLYGVGPLDSPSTSPGVTFSLSAGDIAVHAAGVAHRNVASSPDYEYVGVYPKGSPKWDNNFCKADPDTTKEITAKTEGVPVPAFDPVYGRGGPLVRLWSGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXQ9</accession>
    <name>F9WXQ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_102131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857639.1">
        <property type="nucleotide sequence ID" value="XM_003857591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXQ9"/>
    <dbReference type="STRING" id="336722.F9WXQ9"/>
    <dbReference type="GeneID" id="13403210"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102131"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.399"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943336_0_0_1"/>
    <dbReference type="InParanoid" id="F9WXQ9"/>
    <dbReference type="OMA" id="EMEGAKF"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="314" mass="34657" checksum="52D4820936E075AD" modified="2011-10-19" version="1">MTPARFLLRSSQFAVRSVRPFGTTSRLAAVPTNDRHNDTAETYRKFMKEKPLNPHLTNSTSTIANEMPNIGEDAAPPELITSVDSKFVPKDSKPENTERMTGGTQSGSPKSGPNADLDVGEIEGGTFKVEPIRRTGEDVNTTRARLLYQSRKRGTLESDLLLSTFADENLGAMTKAQLEQYDSFLDENDWDIYYWVTQEPVPTSMAYAEGSGPDMASPEAQGKDVAEQKPDTQGKRVRAPGTGEWAQTVGTFKPAYRPVPQRWKNSEILSLLRKHVIDRSAGSVHIAGKDTSNMDGERKGGGLGFMPDLKNFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXS7</accession>
    <name>F9WXS7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_83566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857544.1">
        <property type="nucleotide sequence ID" value="XM_003857496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXS7"/>
    <dbReference type="GeneID" id="13403115"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83566"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.585"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXS7"/>
    <dbReference type="OMA" id="IPIEHRY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32673" checksum="0043364682291AAD" modified="2011-10-19" version="1">MATTTNTSTETQRKFEVSSNTEIPRGDVRSSLTFYAPPEDGSSPFNYVEQPPEGMPQRNYKENNNEITVHDIRGREHEFDMNVNGFGTISGVQSEEKDFNDDEHIKKVYYPEVEKLLLDNVPGANRIFLFDHTVRRSDPNAKRAPVNRAHIDQTTKSAIARVHLHMGDEAEELLKGRFRLINVWRPLNGPVVASPLAYADSKSVPDEDIVPVEHRYPHRTGETAGVKYTPQGQWHYWSGMTNEERILLQCFDSKDGARTPHSAFVDPRTKPEWPGRESIEVRALVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXX1</accession>
    <name>F9WXX1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_34886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003857367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXX1"/>
    <dbReference type="GeneID" id="13394641"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_34886"/>
    <dbReference type="eggNOG" id="ENOG502QS7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072455_1_1_1"/>
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    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28791" checksum="F2BA5413F7C09890" modified="2011-10-19" version="1">MTSSNNWPVKQYTPRHTSWPYNPSDFTRRDSSSDDRFYSAPRFVTHIDDAAIATLREYYDTVLPRKGKILDFCSSWVSHYPKSVEEAVVNGELKVVGMGMNKAELDANKVLNGGRLLEDLNQDPDISSALREAKAIDADDFSMLDASTNVVSTDYLTKPVEVLKSLREATKIGGTVHLTISNRCFPTKAISRWLRVEEEERLEMVADFLHFAGWKKIEIVELSNGSADSGAPQAGLMKWMGMNARDPLWVVRAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXX4</accession>
    <name>F9WXX4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_33370</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856237.1">
        <property type="nucleotide sequence ID" value="XM_003856189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXX4"/>
    <dbReference type="GeneID" id="13394642"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_33370"/>
    <dbReference type="eggNOG" id="ENOG502QSGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_1_1_1"/>
    <dbReference type="InParanoid" id="F9WXX4"/>
    <dbReference type="OMA" id="LTRQSAW"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="227" mass="24819" checksum="66744489E662AB14" modified="2011-10-19" version="1" fragment="single">IVSDTAFPFERLEKNDSMLLILDLQDGLYSLARDFDPTLYYNAIIAHSAIGKLFDIPVVMTTSAQSGPNGPLPKEILDMYPDAPLIQRQGEVDAWDNAEFRAAIRATGKNQIIMAGIVTDVCTTFLALSLRAEGYSVWANVEASGTTTEFIRDVSNDRMARAGVQMVSLFSVVCDLMRDWRNTPGAAVIIPWLAKYYPAYGILAQAHGGAILNGTIIEGEAVLLPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY08</accession>
    <name>F9WY08_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856257.1">
        <property type="nucleotide sequence ID" value="XM_003856209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY08"/>
    <dbReference type="GeneID" id="13402970"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107169"/>
    <dbReference type="eggNOG" id="ENOG502SXGW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431629_0_0_1"/>
    <dbReference type="InParanoid" id="F9WY08"/>
    <dbReference type="OMA" id="INRNEVP"/>
    <dbReference type="OrthoDB" id="5397734at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="309"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="634" mass="71463" checksum="B7EE895C3746C9BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY61</accession>
    <name>F9WY61_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_98580</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857270.1">
        <property type="nucleotide sequence ID" value="XM_003857222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY61"/>
    <dbReference type="GeneID" id="13394954"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98580"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1188"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_0_1_1"/>
    <dbReference type="InParanoid" id="F9WY61"/>
    <dbReference type="OMA" id="VSDCAQM"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391121" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP92246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="270" mass="25275" checksum="FD93E7CD9E4CE02B" modified="2011-10-19" version="1">MKSFAVVAAVAALASAQTLTDLPACGQAVCIPNMLELAPTFGCAVGDIQCYCRQERFGLGIRDCAQEACGNAGDAQSVIAYGVQYCASALGGAGGSQSGSESSAAATASGSSGASGAAGAQVTTYTSDGSTITSTISGTGGSAQVTTYTSDGSAITSTITDGGAGGIIGGGAAGNGSSATESGDMSMMTGTESGAMMSATDSGAMGSATESSGAGESGSMTTEMNSEPSESSSGGAGGAGASSTSSSSQGAAAMITAAPMLLAGALVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY67</accession>
    <name>F9WY67_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857267.1">
        <property type="nucleotide sequence ID" value="XM_003857219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY67"/>
    <dbReference type="GeneID" id="13394957"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102570"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1195"/>
    <dbReference type="eggNOG" id="ENOG502SFC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115534_2_0_1"/>
    <dbReference type="InParanoid" id="F9WY67"/>
    <dbReference type="OMA" id="WARPRWT"/>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="135" mass="15657" checksum="C85E95BF81090C8B" modified="2011-10-19" version="1">MASIFSSLFRRAPQAPANAIVFPFTIEANPYRCKRIWPPEFENLSEKHKFRLERRYRRRAKLKWARPNWTKGVKLATWASITFVIVYGVLFMETDEGTPFDGIRRAYAEQVSAMNESREDTKADNSSPVALKQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYU7</accession>
    <name>F9WYU7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_15671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857632.1">
        <property type="nucleotide sequence ID" value="XM_003857584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYU7"/>
    <dbReference type="FunCoup" id="F9WYU7">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYU7"/>
    <dbReference type="GeneID" id="13403962"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_15671"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051514_1_1_1"/>
    <dbReference type="InParanoid" id="F9WYU7"/>
    <dbReference type="OMA" id="AMNLKWA"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="23030" checksum="9CB67AEB0C5CEA43" modified="2011-10-19" version="1" fragment="single">INEAEISSTAHAELEQHRELREMVRLAAWEMPLLSSLAKPFEAPDVQKLPLRWRYTTYFGESHPASRKVVVEFGVTNLGLQEKQVEKLKKLAGPRYNPEKNIVRMSCESFETQAQNKRYLADTINTLIAEAKDGKDTFEDVPLDVRHHKAKKRFSFPDEWRLTDEKRAQLEDKRRTLLLEEGKRVEESKIVSGLAAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9X057</accession>
    <name>F9X057_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_66175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856311.1">
        <property type="nucleotide sequence ID" value="XM_003856263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X057"/>
    <dbReference type="FunCoup" id="F9X057">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X057"/>
    <dbReference type="GeneID" id="13402923"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66175"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1007"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="InParanoid" id="F9X057"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000295">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023393647" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023393646" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="300"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1121"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1160" mass="129587" checksum="CA1AFB0B7AAF53A6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0T6</accession>
    <name>F9X0T6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_107726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856757.1">
        <property type="nucleotide sequence ID" value="XM_003856709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0T6"/>
    <dbReference type="GeneID" id="13398556"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107726"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1948"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545146_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0T6"/>
    <dbReference type="OMA" id="VMEAIVW"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="533" mass="58559" checksum="13E52CC737074331" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Z4</accession>
    <name>F9X0Z4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_65863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856205.1">
        <property type="nucleotide sequence ID" value="XM_003856157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Z4"/>
    <dbReference type="FunCoup" id="F9X0Z4">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0Z4"/>
    <dbReference type="GeneID" id="13403016"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65863"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.810"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0Z4"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP91181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="421" mass="46749" checksum="0027856D5E94ED5B" modified="2011-10-19" version="1">MPTAVSPPTNPPDLSKKLPKLTPRRRPQSDETPSNPPPPTPNLAPPPNLKDHNFTRPSRRILSERDHDLFTSSASHDLIISFVFHLSDSVRDTTISSIQKSEAARDPAIVALLAVLDDADRLVKECPPLDTGSRFGNPAFRDFLTAVDNAKPQWHTQLGVTDTAAQQEISTYLSQSFGNGSRIDYGSGHELNFLLWLLCLRQLSLLPTHLFPALTLLVFPKYLSVMRSIQSTYYLEPAGSHGVWGLDDYQFLPFLFGASQLVDHKHIRPMSIHNELIIEECSKDYLYLDQIRWVNATKTVQGLRWHSPMLDDISAAKGWAKVEGGMRKMFLAEVLGKLPVAQHFMFGSILPAAEGMSKDAEEKVGEDEVGEVEVTVDGMRHVHNPTSWGDCCGIKVPSAVGARQEAQKMGQGNGLRRVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X148</accession>
    <name>F9X148_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_107279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857320.1">
        <property type="nucleotide sequence ID" value="XM_003857272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X148"/>
    <dbReference type="GeneID" id="13402891"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107279"/>
    <dbReference type="HOGENOM" id="CLU_940751_0_0_1"/>
    <dbReference type="InParanoid" id="F9X148"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP92296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="296" mass="33104" checksum="89BA409DB9216D46" modified="2011-10-19" version="1">MPGRREHGHASLAALSLPARCSLLSRAPVNKSRTGLALSEWIIQLQDGRPTTLSGSFRDRPYPVCHVRGALVWARDLSSVGNVTDSITLFPPIAQPLYHYRQRDPPSSQPDQALLNVPDMRKDRKGFATRSHKLQQVASSADCQQRWRLAEGRDEPLQSRPGPCRRGHYLDPAEREDNVTGCPRCPSTSPHQVLLPRKHRHSCIPGTLDRGKGSTKQDVSRFGYHSTLLYMGSFTLSRSDESQTLWVVHGYVGHWTSIGSSAISRERPRDPTQVNLPARKPYHITRYAIAVLTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1B7</accession>
    <name>F9X1B7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="7 15">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_53893</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="7 15"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856582.1">
        <property type="nucleotide sequence ID" value="XM_003856534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1B7"/>
    <dbReference type="FunCoup" id="F9X1B7">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1B7"/>
    <dbReference type="GeneID" id="13398968"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53893"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1553"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036010_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1B7"/>
    <dbReference type="OMA" id="GDGYRRM"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 15" id="KW-0288">FMN</keyword>
    <keyword evidence="13 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="16">
        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP91558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="334" mass="35650" checksum="47C3D08C321B1816" modified="2011-10-19" version="1">MPLPRISPPLVNSANPWCTTREHLQNLFDSTNTGAITTRTSLLNAFKHDPRIHQFAFFDGGDHTSMLDDYEEAEIPASHGGSLNTLGYSPISLTAYLDMIEIVIADSKLPDHIRKNKPVIISVTGSSDAVVKCYRMIQDAQQKLSNPLCMEINLSCPNIPDKPPPAYSKLALIEYLQAVANVPNPTSSMRVAIGIKTPPYTYHDQFQILIDALKESSSPTCPIDFITATNTLGSSLLLGDIDGTPVLSSASGAGIGGMAGTPLHPLALGNVRTIRTMLDQHEELRTIDVIGVGGVGDLAGYMRMRSVGAAVVAVGTALGREGVAVFGKILQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1C2</accession>
    <name>F9X1C2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_32500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856585.1">
        <property type="nucleotide sequence ID" value="XM_003856537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1C2"/>
    <dbReference type="GeneID" id="13398966"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32500"/>
    <dbReference type="eggNOG" id="ENOG502SJ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1C2"/>
    <dbReference type="OMA" id="FCGGDCL"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF87">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395266" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="99"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="388" mass="41132" checksum="56F500204D679B9A" modified="2011-10-19" version="1">MKSFAAAAVAASIVGVASARQCQNLTVPVVITARNAVFDKEALTPKNNIDVTNIILTGTQQGHNATAEALKGYADVSGTYHIAATYCEPDSGTPTTIQILTHGIGFDRSYWDFSYNNYNYSYNARAVDEHGYATFAYDRLGIGQSSIGEPVNEIQVQLEIAALKSLTEDIRSGCIEGVPAFHKVLHAGHSFGSVQTYALTAMYPDISDGIVLTGFSQNGTFLPFFQLGGNFVQANLNSALSKYPDGYLAAGSPSGVQTNFFSPGDFDPLLLPVAFKTGQPVTVGELLTIGGAAGAVNQFKGPVLIITGERDVPFCGGDCYKPPTGFKSIPETSKAMFPATSKFEVQIVPGAGHGLNLEYTAPMTYSTIATFLAQNGLAPSSSMRTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856899.1">
        <property type="nucleotide sequence ID" value="XM_003856851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1J5"/>
    <dbReference type="GeneID" id="13398260"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90212"/>
    <dbReference type="HOGENOM" id="CLU_2063336_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1J5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="12507" checksum="3E286E65F839DB73" modified="2011-10-19" version="1">MQQAGSILPTGHSVHQRAMLNVDAQPVHVNPLTGDTRGTIPIVVNDNHTKTPTRNMHLSTTTPLMALVAVLFSLATQALSAAVPEPHANIGARAPSPPPPTEECSYPDSCRINPALCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1T9</accession>
    <name>F9X1T9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855361.1">
        <property type="nucleotide sequence ID" value="XM_003855313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1T9"/>
    <dbReference type="GeneID" id="13400061"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91066"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.967"/>
    <dbReference type="HOGENOM" id="CLU_1897855_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1T9"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="134" mass="14668" checksum="86C702350E55DBF0" modified="2011-10-19" version="1">MDYLRHLVRKGLIDPGAVDIAQAQRDPPNFGIGLRPVGLRPQPAQRPDDANDPPLSENGSWIVGNELQAEDSSARAEVDIDVGIDDVSYVSTPPSSPDAEDNEDTEVEGEAEEEEEDEGEAEEEEEDEGEEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1V1</accession>
    <name>F9X1V1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MgABFB3</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_68922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855124.1">
        <property type="nucleotide sequence ID" value="XM_003855076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1V1"/>
    <dbReference type="STRING" id="336722.F9X1V1"/>
    <dbReference type="GeneID" id="13400750"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68922"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.980"/>
    <dbReference type="eggNOG" id="ENOG502QUZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1V1"/>
    <dbReference type="OMA" id="QYDDWGG"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391223" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP90100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="321" mass="34360" checksum="E7B73090537AD501" modified="2011-10-19" version="1">MKFAETIILFATSLSSVTAQCRLPTTYKWTSTGALAQPKVNGAVALKDFTAVPYNGQYLVYASTGSASGTYSSMMFAPSSLQNLGSAAQTATPFSAVAPTLFFFAPKNIWVLAYQWGATAFRYRTSTNPSNVNGWSADQALFSGSITGSDTGPIDQTLIGDASNMYLFFAGDNGKIYRSSMPKANFPGSFGSASTVIMSDTRNNLFEAVQVYTLGGSNRYLMIVEAIGSQGRFFRSFTATSLSGSWTPQAATESNSFAGKANTGVSWTNDISHGDVIRSTADETMKIDDCKLQVLYQGRSPTSGGDYNALPYRPALLTLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X282</accession>
    <name>F9X282_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855598.1">
        <property type="nucleotide sequence ID" value="XM_003855550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X282"/>
    <dbReference type="GeneID" id="13403538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103208"/>
    <dbReference type="HOGENOM" id="CLU_2724157_0_0_1"/>
    <dbReference type="InParanoid" id="F9X282"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="72" mass="7628" checksum="296CEE181A8C8397" modified="2011-10-19" version="1">MVRTQQAMLNMMAQNAAPQNAPAAPASSRPGPHHRTNTVQSAASATVNQPNQQNPTNLDRPGLTAEERAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2R5</accession>
    <name>F9X2R5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CIT2</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_103124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855670.1">
        <property type="nucleotide sequence ID" value="XM_003855622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2R5"/>
    <dbReference type="FunCoup" id="F9X2R5">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2R5"/>
    <dbReference type="GeneID" id="13396021"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103124"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.334"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="F9X2R5"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
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    </dbReference>
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        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
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    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
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        <property type="entry name" value="Citrate synthase"/>
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        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <position position="310"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP90646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="474" mass="52363" checksum="9D8D743F6E7D8CFF" modified="2011-10-19" version="1">MAINSVSRQALRRSMAAPSTWTQRSALNASRTYASSSKSASLKETFAASLPEKIDQIKKLRKEHGHKVVGEVTLDQVYGGARGIKSLVWEGSVLDSEEGIRFRGRTIPECQEILPKAPGGQEPLPEGLFWLLLTGEVPSEQQVRDLSAEWAARAEVPSFVTELLDRCPSDLHPMAQFSLAVTALEHESAFAKAYARGIKKAEYWEHTFEDSMDLIAKLPTIAARIYRNVYKDGKVPAIQKDKDYGYNLANLLGFAENSDFVELMRLYLTIHTDHEGGNVSAHTTHLVGSALSSPMLSLAAGLNGLAGPLHGLANQEVLNWLQEMKKSVGSDLSDENITKYLWDTLKSGRVVPGYGHAVLRKTDPRYVSQREFALKHLPDDPMFKLVSQVYKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEQNFYTVLFGVSRAIGVLPQLIIDRAVGAPIERPKSFSTEHWAKLVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9X360</accession>
    <name>F9X360_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855292.1"/>
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    <dbReference type="AlphaFoldDB" id="F9X360"/>
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    <dbReference type="OMA" id="TEEAFIC"/>
    <dbReference type="OrthoDB" id="3650678at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="335" mass="36824" checksum="425B8ABDF0F44381" modified="2011-10-19" version="1">MAPQRSSIPGPGHRSTVEGRRQVDRSARKSLPIPRAKSTAALPTYTPSTASPMQPPTIHHRSSSIAKLSSFGEPPHKRSDSVLTNGSSRSRPPSRLHTSKSHGLLTPPSSTSSRSSLLYAKDSPSSPPCALHTSSRSRPLPAAVAGRTTSAKATPKSPSSPYMNMHITDPCIPGCLIHQLSPCGHKILTPKPEPCASNCKQRSPNTPSGTPTQDAFVCAACVELHVQVHREVKRDVYQHNLEQTEVQMGKFPPDWIKQQQKYWEKVWENDMLKEKESFERLGRSCMAIPGEPIEEGMGKIVDNESVVTAVPWPPTKRPAKVRISEWRPRIGQDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3M0</accession>
    <name>F9X3M0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_84542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3M0"/>
    <dbReference type="GeneID" id="13403574"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84542"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="F9X3M0"/>
    <dbReference type="OMA" id="SIYMLCW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53788" checksum="AFF1889B3D24AAD4" modified="2011-10-19" version="1">MISGDEYSPAEYKRVLRKIDRFLLPLMWCCYGVQQTDKTSLGVQAIFGLPKDTGLVGQQYSWLTTIFYLTYMVGEFPSNFLLQKWSLGKTLSIYMICWGVCVTCIGAAQNWTHLMVLRGLQGFFECTISPGFVLVIGSWYRTEEHSSRSLFFQSANAGFGIIGNLSMYGIGSHTKKHGGLAAWRSISFFLGAVTVVLALICFILLGSPKEVRWLNAEERKVAQSRVVSNKAGRDVTGIKWSWPQVAEAFKDPQLWFCLVNAFLSSVPNGGLTTFSAIIMKSFGFTELQVLLLDIPRSTISVLIFVAVGFYTRRVPNRRMYVMAASCVPAFVGLLAMSLLPNTPEYQWTKYAMYVITVPYVLGLFLAWTLIPSNVAGRTKKTIISSATFIGYCVGNMSGSQIFKSKDAPRYVPGTIGACACFGIQFVLVIAWRLYYVWQNKRRDRAAAASGISKEEQERLGQEMGERNMTDLENVHFRYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9X412</accession>
    <name>F9X412_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hard surface induced protein 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_69046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855300.1">
        <property type="nucleotide sequence ID" value="XM_003855252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X412"/>
    <dbReference type="STRING" id="336722.F9X412"/>
    <dbReference type="GeneID" id="13400263"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69046"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.1095"/>
    <dbReference type="InParanoid" id="F9X412"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="466" mass="52865" checksum="664A61F763CB2E2A" modified="2011-10-19" version="1">MLDSAGAGTRHWTSQIAHLLHPRNLTLFRSTKEVNSQTGHLDGLRGVAAFIVFICHLAYSSHDVSIGWGYTGERQQETGNSYTQWLRLPIIRLVCDGDPAVAMFFLISGFALSWRPLKLAREQEWAKFARTLMGSTVKRWPRLFLPVLASTGFICLAVQLGLYDLTRGIAHDKTLLTVFQEPHPEAKANIFVMLGSWLHANWSLWEPFHWDRDAFLEYDIHLWTIPVELRASMGLFVTLLAVGGMKSNVRMAILAILIVVGCLKDNWAMMMFWAGALEAEIILSRQASSVPYHDVDKDSEPVQRSSTNSMFRGLILVLSLILMSEPFEPQDTYGWRALMPFIPSNFSEKRRFYTCIGSMICFHLLNSEPKVCAFFRSNFIQYLGRVSYGLYLVHGFIIHTFGYAMFSFVWRFTGVETAFAREIGFGIAAAVIIPCTLYVADVFHRGIDEPSVRLAKWIENQVIVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4B8</accession>
    <name>F9X4B8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_22011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855619.1">
        <property type="nucleotide sequence ID" value="XM_003855571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4B8"/>
    <dbReference type="FunCoup" id="F9X4B8">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X4B8"/>
    <dbReference type="GeneID" id="13403559"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22011"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="InParanoid" id="F9X4B8"/>
    <dbReference type="OMA" id="CEREGND"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="112"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="506" mass="56143" checksum="9EA62CA69E6E4B97" modified="2011-10-19" version="1" fragment="single">LVYGTLILYGLHLLLDYFEVAILSPQELLFNAVVYCIPTPLLLDSARRNELRENNMLSQTHAAKSDAFRRAMGLGGHALLQKGESIGMGGVMRRASMIAGARPVVVTSDAPAGLGNWDNSCYQNSVLQALASLVSLRSWLSVSEPPGAGPETSTNTALQTTIAKLRDPANNGNHIWTPAQLKNMSSWQQQDAQEYFSKIVDELEKEATRAAALKKQPGLETLVDAQHEGGNDQDVLRNPLEGMTAQRITCTRCGFSEGFSMIPFNCLTVPLGSSFDQDLEDCLDEYTKSEDIEGVECNSCTLIQAESQLKQMLLTSKSGDATSPPQSIAMPPELRAQIEARLLAIQHALEMDDFSDKTLKQDCQISPKAYASTTKEREAVLARAPESLAIHINRSIFDELTGAQRKNHAHVRYPAILDLEPWMASFCSTPTRYALQAVVTHYGRHENGHYICYKKHPRRLDDEVELDEDVPQKESWWRLSDEDVSLAPEEDVLGQGGVFMLFYERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X4P4</accession>
    <name>F9X4P4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_68855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Maliepaard C."/>
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                <person name="Schouten H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855190.1">
        <property type="nucleotide sequence ID" value="XM_003855142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X4S2"/>
    <dbReference type="GeneID" id="13400283"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91216"/>
    <dbReference type="HOGENOM" id="CLU_2225323_0_0_1"/>
    <dbReference type="InParanoid" id="F9X4S2"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="106" mass="12128" checksum="958D9FAE4B38A7FC" modified="2011-10-19" version="1">MDQSAGVTTVLPLEHLARKGVRTARPNHVSEFVYCDTSKQHTLALDFYPVDRWQVDPVWLQGGPKRDEIRESAHGVFREHGWPSLAAYRKSECLQALKKALDEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X569</accession>
    <name>F9X569_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_70252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854284.1">
        <property type="nucleotide sequence ID" value="XM_003854236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X569"/>
    <dbReference type="GeneID" id="13404337"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70252"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.843"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="F9X569"/>
    <dbReference type="OMA" id="QICEICI"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="341" mass="39187" checksum="E31CA9A0ACE5E3D7" modified="2011-10-19" version="1">MTSQQKTAVNIVFGAMTIGKEGAEQARVHDLKTAGEILDIFQKHGHNEIDTARAYGAGSSEGMLGELEWQKRGIVMDTKYYPTIAFSDTPSNWAAKGSRHTPQELRENLEASLKALKTDKVDMWYLHGPDRTTPYEETLKAVNELYKEGKFTRLGISNYMSWEVAQICELCRTNNWIQPSVYQGVYNALHRSVEPELFPCLRKYGMAFYNYNPLAGGYLTDRYHRETQDMEEGSRFDPNRWQGKMYRTRYWNDSYFDALDILRPVAKKHGLTEAECALRWMTHHSQMKREHGDSIIIGASSTKHIEQNLVDLEKDALPEEVVKALDQGWEGCKAISGKYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5D4</accession>
    <name>F9X5D4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854670.1">
        <property type="nucleotide sequence ID" value="XM_003854622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5D4"/>
    <dbReference type="GeneID" id="13400907"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91304"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.22"/>
    <dbReference type="HOGENOM" id="CLU_572681_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5D4"/>
    <dbReference type="OrthoDB" id="10590609at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="477" mass="52394" checksum="F048D8513876B39E" modified="2011-10-19" version="1">MPSRYIPETLTTLIEADDEDSEASAEFKVVLRTCVEGSSLLDTRHECAMLETVNWSANRLEEAVRNGLDPNEVERQQIEAAEFQTVLWKGRNEQQKFQNAGERVRDKERDIPPPPPAASTEPFTSKANGLTQVQQEKRREGTSQADTAQAAFTQANSTQATSPQVASSQSTSSRTTTTKPFTFAAHSSTQTLQEKQSTESSRAASSQSAATMPSRVAGSGSSQSEVERLQGLTIELQAELLREKTVTTDLQAELLKERKENESLRKECERLREKEKGSQPPPLGRIRSNRSTGLPMTTPSSTSSAPDPLRPTGNVLSQEAAPKPSKRPARGPVTPAPKKKQAKAAANRDATDEVLAMIRVKPAGSAPGVALEEFSEILSQSIRESIRPFAMKPYIVNGKWIEGCFVAKSYQVSPIFDRDTKNKKNGINACADCMSRRLPCIFMDPSGDKPEALLLPLPEEERPEGATPDEVRYYCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5H1</accession>
    <name>F9X5H1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MgAMY6</name>
        <name evidence="6" type="ORF">MYCGRDRAFT_108486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
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    <dbReference type="GeneID" id="13395741"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108486"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.236"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_1"/>
    <dbReference type="InParanoid" id="F9X5H1"/>
    <dbReference type="OMA" id="SGPRMHE"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
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        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
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        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="578" mass="65971" checksum="D050D267D1D34F91" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5R5</accession>
    <name>F9X5R5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_91768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9X5R5"/>
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    <dbReference type="eggNOG" id="KOG0773">
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    </dbReference>
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    <dbReference type="InParanoid" id="F9X5R5"/>
    <dbReference type="OMA" id="YYPRASY"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="433" mass="48656" checksum="9B6654020F42B084" modified="2011-10-19" version="1">MESLTLNEGHSFRRYQDRPQSKDQRHRPSRLPTPDTSRSSNDSQSPPESGSLDFPTVTKFGLAGLPDGVGQQRRDSRYSAGQYSPPYRPDDMQRPSLPPIKTVLGDNIASPPTTPSPHGTPMQPSPHEPLYTALAYKPSSLYPNKKQRTEPFPSLGPQYATANRSGSHFAPSATLEPQPTGSSMGPNMQFPPISQINTVDSRRASSSHNSPPWSSHYPPSKVAAASHYQTPAPTPTSAVMEPFPRMTTLPAPAAQDPFAREMRESFSYNGDRSGPRRPASAYNTYTARPYEREPLRQSPYHPQGVRYSLPVRGSFADNRDSIRYGRTDEQQPRSFGQTTYQGNVPSYFMPSQYEYQHGKARKRSNLPKQSTEIMKTWFDQADDTSYEALTNIEQATGINLTQVSNWFINHRRRCPELRDKRERVRGGSRDCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X648</accession>
    <name>F9X648_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_18787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854526.1">
        <property type="nucleotide sequence ID" value="XM_003854478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X648"/>
    <dbReference type="SMR" id="F9X648"/>
    <dbReference type="STRING" id="336722.F9X648"/>
    <dbReference type="GeneID" id="13404080"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18787"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121504_0_0_1"/>
    <dbReference type="InParanoid" id="F9X648"/>
    <dbReference type="OMA" id="WSTIRAN"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="143" mass="15971" checksum="7692CD49FB88C9A8" modified="2011-10-19" version="1" fragment="single">TGVKYFVIKSWNLANVHAAQRSSVWSTQTKNETLLTQAFRTSRQVILFFSVNKSMAFQGYALMTSAPDSSIAKPDFCKKLNWDTSAAFTIRWLSTTSVPFRLVGHLKNRLNLDEQGVARPVLIGKDGQEVCEEAGKGVVRVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6M9</accession>
    <name>F9X6M9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_69333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854602.1">
        <property type="nucleotide sequence ID" value="XM_003854554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6M9"/>
    <dbReference type="FunCoup" id="F9X6M9">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6M9"/>
    <dbReference type="GeneID" id="13404013"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69333"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="InParanoid" id="F9X6M9"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="548"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="867"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115531" checksum="A2FFE21E82C3A659" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X4</accession>
    <name>F9X6X4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_91840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853917.1">
        <property type="nucleotide sequence ID" value="XM_003853869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X4"/>
    <dbReference type="GeneID" id="13404256"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91840"/>
    <dbReference type="eggNOG" id="ENOG502RCNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171409_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6X4"/>
    <dbReference type="OMA" id="DICLWIC"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="237" mass="25802" checksum="9528884E3E984F54" modified="2011-10-19" version="1">MALIPRAASSFIHYEQIPFIVFTIILMVITLLSTCFGIHRRISVSGKLLVEDVFALLATIAALALSSTFTIDDDLNDGDNLEIIRKVSVVALYSYIAAVLFLRTSFLLLYLRLDRRIIMRWIVLALSPVVLTQTCSLVIGAAFSCAPPTLIWTTSIASSGRCWTSGSIQTFLNVSGILVSAVDASILAASLSMAGTRRGLRLAVSDATTLGLSWTPIIRIEKSHSLPCSLRLKSIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X787</accession>
    <name>F9X787_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_56633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853792.1">
        <property type="nucleotide sequence ID" value="XM_003853744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X787"/>
    <dbReference type="FunCoup" id="F9X787">
        <property type="interactions" value="634"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X787"/>
    <dbReference type="GeneID" id="13395650"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56633"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.433"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="InParanoid" id="F9X787"/>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="407" mass="44736" checksum="F865116B109107F5" modified="2011-10-19" version="1">MDNADSVPKEVWEALDQATTSPVYFLLVLGVGGLIGGLVVLYVLLSLFAPIPRPPRQSEKRYITVNEDGQTSSPRLLPCWYDSNVALKELAKSKEISREESFQIDDAEIFMSLVIPAYNEQDRLSGMLEEAVEYLEEQYGDHAMASKSSSNGHANGKQGHARKGWEIILVSDGSKDKTVEVALNFARTHQLGKPPPTPQGPWNTPGSEKPTRILPGTIRVVQLEVNRGKGGAVTHGMRHARGKYVVFADADGASRFTDLGSLVEACEKAKDKEGRAVGVGSRAHMVGTEAVVQRSALRNLLMRAFHLGIWLLTTPRVAKIKDTQCGFKLFSRPSLPYIVPYMHSEGWIFDVEMLMLAESADIPMVEVPIGWKEVLGSKLNVIKDSIGMAVGLGLLRVAWGIGVYRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X788</accession>
    <name>F9X788_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_38100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853793.1">
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</entry>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Maliepaard C."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Stergiopoulos I."/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
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    <sequence length="139" mass="15221" checksum="ACBD92CC007834B2" modified="2011-10-19" version="1">MSTRKRKQEAEEEEELQSLPEDSEEEEEYISENDEEGASASEDDDEDAEEEVEEEEAAAPAEPKSKKRKTAPAPAEDDDEEDAEAGDDDDEEAVPEEDDDEDEDTAKSSGPAAAAKKAKNGVVPKEKSLEEVDDAEDDD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
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                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="271"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
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            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="608"/>
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    </feature>
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        <location>
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            <end position="552"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="646" mass="73114" checksum="1B60C6F58EF4D752" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39210"/>
    <dbReference type="eggNOG" id="ENOG502SXI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190852_1_0_1"/>
    <dbReference type="InParanoid" id="F9X7L7"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="73" mass="8486" checksum="627BC6A4E2E60681" modified="2011-10-19" version="1">MCEYTKVEYACGHLRFTVRAWCIKYQESHKRCPANVVAVEYRLDERCGKAALGLESIHFVLNNHQVTAETLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_38554</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854457.1">
        <property type="nucleotide sequence ID" value="XM_003854409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R8"/>
    <dbReference type="STRING" id="336722.F9X7R8"/>
    <dbReference type="GeneID" id="13395644"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38554"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7R8"/>
    <dbReference type="OMA" id="CIKAEST"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
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        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="295" mass="33164" checksum="15DC8978593D0A34" modified="2011-10-19" version="1" fragment="single">AAAVEEYYQLYLPSDDRPHGYIIPEIVSKMPWTDQFSVEHEHPRRVTILDVSNRSDFARTITAAFQELVDTCIDRNLFRVLSGRHSEHVTILSAQYDRPVCIERFAANLFGVTRSGAHLIAYTTSRSDEMKIWVPRRSPHLFTYPNLLDSTVAGGVKAGASPLQTVVEEANEEASLPEELVCRCARSRGVVSHMGLTGKGFAGEQGLVEPNYMYVYDLELPADIVPRPHDDEVEAFHCMSVEEVQTALLAEAFKPDSAAVMVDFLIRHGFITPENEPDFVEISMRLHRTLPFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X832</accession>
    <name>F9X832_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_17911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852810.1">
        <property type="nucleotide sequence ID" value="XM_003852762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X832"/>
    <dbReference type="GeneID" id="13397131"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17911"/>
    <dbReference type="eggNOG" id="ENOG502SQRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_4_0_1"/>
    <dbReference type="InParanoid" id="F9X832"/>
    <dbReference type="OMA" id="CSRPYLN"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="179" mass="20121" checksum="D85D97C5053AE7EC" modified="2011-10-19" version="1" fragment="single">YAIPQNIRSHFEDNAITAKCLSLQNYEPTVPWARMQGSANGLFLSTLNNENTIPHWITLRTKQRRNLPTAPTPGVEVSTTTKPDLITLIHLGGSGVCSFHNTLHGGMISTLFDEVFFATLNHVMYTHPADVDNPTRFSTMQLDVKYRRPVRVPGIVVVRAWCLAIAGRKCWTYAELLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8M0</accession>
    <name>F9X8M0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92841</name>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Hane J.K."/>
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                <person name="Bristow J."/>
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    </evidence>
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                <person name="Van der Lee T.A.J."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853373.1">
        <property type="nucleotide sequence ID" value="XM_003853325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X921"/>
    <dbReference type="STRING" id="336722.F9X921"/>
    <dbReference type="GeneID" id="13397362"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92641"/>
    <dbReference type="HOGENOM" id="CLU_1023804_0_0_1"/>
    <dbReference type="InParanoid" id="F9X921"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="30053" checksum="3A4513B4ED45F147" modified="2011-10-19" version="1">MLSSYATRFLAKRPLTTTSRPYVSFRPSLNATQPTTRSISSISSASNALQRIRQATLADSLKALRLDGTTASQALAAHQIRGMKVRSSVKKLCDGCKSHGHWRIGMGTGICLEESSNMDAREAEGHTRDHSRDEARSRIETSALAWSIDPPYETEVNQYLDFILDKYEEIQQMLASSLVEAKAKRARDDDGIEIVALTDLTTVEEVFAALQKSLGRPFEGKEILSFFVSIPDEEEPFRIDKGDTDDGGWEAVLCVVKEGNLTKLSGVVEAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9A8</accession>
    <name>F9X9A8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_30802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853174.1">
        <property type="nucleotide sequence ID" value="XM_003853126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9A8"/>
    <dbReference type="GeneID" id="13399538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30802"/>
    <dbReference type="eggNOG" id="ENOG502SH6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103467_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9A8"/>
    <dbReference type="OMA" id="FDRKCAA"/>
    <dbReference type="OrthoDB" id="4426724at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395415" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19153" checksum="C0B612F854AC1E3B" modified="2011-10-19" version="1" fragment="single">LITLSLALATSVTATMSWSLDRVANPTEDESDAYNRITDAMNAAIARWQPYWLANKHCTVSYVPGIGTADGNYNGNIRFGSDRQYMVEGYALHEIAHVLGVGGGNPRFYANCQNHEWPLASMVIAKYYGQGEVLHCAGEHFYPYGLNFADEFSEENYARHCEVVDAMIRDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9Q1</accession>
    <name>F9X9Q1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_104237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853071.1">
        <property type="nucleotide sequence ID" value="XM_003853023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9Q1"/>
    <dbReference type="STRING" id="336722.F9X9Q1"/>
    <dbReference type="GeneID" id="13399284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104237"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_4_5_1"/>
    <dbReference type="InParanoid" id="F9X9Q1"/>
    <dbReference type="OMA" id="VAHTCFH"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="125" mass="13815" checksum="629CAD9065AE752E" modified="2011-10-19" version="1">MKALKAYVEGSDTLDINDLRAATRYDGYDAKSRYITSFWDVVTSWSQEKQKQLLKFVTAAERIPITGASQLTFVIKRGHPESLNNLPTSSTCFGTLILPKYASVETLKEKLSKAVEYGAVGFGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA43</accession>
    <name>F9XA43_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="721"/>
        </location>
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            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127597" checksum="D10F13685CD1BD39" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        <name evidence="10" type="ORF">MYCGRDRAFT_58400</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 115943 / IPO323</strain>
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            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
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    <comment type="subcellular location">
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            <location evidence="2">Endoplasmic reticulum lumen</location>
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    <dbReference type="eggNOG" id="KOG0191">
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        <property type="entry name" value="Thioredoxin_domain"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
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    </dbReference>
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        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391494" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="320"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGP88240.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852728.1">
        <property type="nucleotide sequence ID" value="XM_003852680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAV7"/>
    <dbReference type="FunCoup" id="F9XAV7">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XAV7"/>
    <dbReference type="GeneID" id="13393866"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_29864"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018580_2_0_1"/>
    <dbReference type="InParanoid" id="F9XAV7"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP87704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="442" mass="49998" checksum="1A3A3375840ABFCC" modified="2011-10-19" version="1" fragment="single">WQCILQAPCTFPSSLFSDVLLNIIRNPNLTSPLLFRADILYDSETDHLFDADGTWGEENGGAKRGEWEGWKLQRVLVRMLVPRNERRDEGMVQSCWLLRKSDESEDGSGTMEHHLVVLVPHVEAVEEMPFYHPAVEQLAFLHSWRAAPSPPRAPPEQDQCEFEIGDEQPGTLTLLIHRTSQILLSTIHKHATGLLTGYTKRVHHDRLIPQAQYQNTYSRLKSKYGRTISEQWVEVTDPGKHVFEDLGIAAWCIEVWRMLYEWPKGKPPFPGFVDIGCGNGLLAYILLSEGYPGWGFDARERKTWSIFPPEIRAKLQQRVLVPRTLQGEALGDGVQWHNGFFEPGTFIISNHADELTAWTPLLGYLNGSSWMAIPCCSHDLGGKRFRAPARSRGMKMPSAYSTLCSYVSSLSREVGYTPEEDILRIPSTRNTCVLGRANVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBI2</accession>
    <name>F9XBI2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Mg77997</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_72420</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852524.1">
        <property type="nucleotide sequence ID" value="XM_003852476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBI2"/>
    <dbReference type="FunCoup" id="F9XBI2">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBI2"/>
    <dbReference type="GeneID" id="13396846"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72420"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="InParanoid" id="F9XBI2"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="52221" checksum="71C0E4784A5C496B" modified="2011-10-19" version="1">MQPLSGTEVYSLGILSVACIAILINAWQSDGEPLYASLAISGLAFAFSYAVIRWTGDVFLKRGYKGKDLSKKNPIELPELMGLISALVYLLAIINFLPFAFKRDMIQVTSAAGNMDAILEAQQLETGRFLHRFPLRKARRLTRILPCHLASYGFAYGTLASTIILGFLDDSFDMRWRHKFFIPAFAVLPMLGLYYVDFGITHVVVPLPLRGYLGELIDLGGLYYAYMAAIAIFCPNSINILAGVNGIEVGQSLVIASLIALNDALYLLPTVQQPHPAAESHLFSIYLLLPFIGVSLALLRHNWFPAQVFVGDTYCYFAGMLFAVVGILGHFSKTLLLLLIPQIFNFVYSAPQLFALVPCPRHRMPRFNARTGLLEASVATFDTKPLRPIVGEVLKILHTLKLLRVKVDATTGRVLETSNFTILNLWLVWRGPLREDRLALEILAMQTACGLAGLWIRHSLALLLFTADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBM4</accession>
    <name>F9XBM4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_93126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852135.1">
        <property type="nucleotide sequence ID" value="XM_003852087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBM4"/>
    <dbReference type="GeneID" id="13393910"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93126"/>
    <dbReference type="eggNOG" id="ENOG502SNAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826932_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBM4"/>
    <dbReference type="OMA" id="LRTHATW"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="113"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="36963" checksum="5F0AF086317E87FF" modified="2011-10-19" version="1">MPGNLELPPPEVIAAWPAPNHVNPERRAWMPAFSGTLQAVTTLLVVTRLILRAQRRAGGLGIDDAMLFLGFLAGTMFTCVAILGAGQYGFDRHIYDIDFTKVTETALIAWLSQLAFLVAYCIAFVGVLIGGCRPVNAYWRAYDPVYAASVEYTCIPTKFLNPLSGGLSVVSDFYAVVLPIGLLWHLKISKRQRYALNAVFSLGFVVVIVGIVRTVSFLRSNTVLDSNTGGISNMSFRESADGAKILSTFQVEQWSVRDGDFGSLILGKAEQEWTTVHEIEVDEITTMPERTAIRTASEYEALALEDIKNFKASNLYSGWRNSSENSSEVDGSSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBN1</accession>
    <name>F9XBN1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_104431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852139.1">
        <property type="nucleotide sequence ID" value="XM_003852091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBN1"/>
    <dbReference type="STRING" id="336722.F9XBN1"/>
    <dbReference type="GeneID" id="13397008"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104431"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2238751_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBN1"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP87115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="105" mass="12232" checksum="61F36275A4E89D71" modified="2011-10-19" version="1">MNLEVNLDRPDIDLQQLTEEPTHEKPAQPDRVKDRLSYKHLAYSTDLTRVDTKGLSPKYELELEVDANTLRHQKHLMQTGQENGYQAVVEGFMENLTLLMRQPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBV5</accession>
    <name>F9XBV5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MgBGL11</name>
        <name evidence="17" type="ORF">MYCGRDRAFT_42323</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852313.1">
        <property type="nucleotide sequence ID" value="XM_003852265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBV5"/>
    <dbReference type="STRING" id="336722.F9XBV5"/>
    <dbReference type="GeneID" id="13396823"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42323"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.645"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="InParanoid" id="F9XBV5"/>
    <dbReference type="OMA" id="WENIATV"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395446" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="785"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGP87289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="864" mass="92488" checksum="FE3E747F6FDE9A23" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBZ9</accession>
    <name>F9XBZ9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_72043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852171.1">
        <property type="nucleotide sequence ID" value="XM_003852123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBZ9"/>
    <dbReference type="FunCoup" id="F9XBZ9">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBZ9"/>
    <dbReference type="GeneID" id="13393947"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72043"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.327"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="F9XBZ9"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
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        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="207"/>
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            <begin position="289"/>
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            <position position="207"/>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87147.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="331" mass="36012" checksum="50C5BB28FBDBDF30" modified="2011-10-19" version="1">MDGLPLNNALAAVTALVFSFIGILWLSLKILSFWRLIASLFILPGTSLSRFGKKGTWAVVTGASDGIGKEYAQQLAGKGYNILLVSRTKSKLDTLASEIQAKYKVETKVLAMDFAADKDTDYASLKELVNGLDVSILINNVGQSHNIPVPFNETPEKELRDIITINCMGTLRVTQLVTPGMIKRKRGLILTMASFGGIMPTPLLATYSGSKAFLQQWSSALSSELASSNIKVQLVQSYLVTSAMSKIKRPSLLIPTPKKFVRAALSSIGRHGGAQGVPATCTPYWSHAIMQWAISTFVGTQSGIVLWINKSMHQGIRKRALRKAERDAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC88</accession>
    <name>F9XC88_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_58978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852587.1"/>
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    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Smr_dom_sf"/>
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        <property type="entry name" value="Su(sable)-like"/>
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        <property type="entry name" value="Znf_CCCH"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="630"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="77790" checksum="6254C4ADEC8FACBE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCD4</accession>
    <name>F9XCD4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Paf1p complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAFE2401</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_14858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852466.1">
        <property type="nucleotide sequence ID" value="XM_003852418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCD4"/>
    <dbReference type="FunCoup" id="F9XCD4">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCD4"/>
    <dbReference type="GeneID" id="13394125"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_14858"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="InParanoid" id="F9XCD4"/>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="255"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="418" mass="46623" checksum="930D9211671A8365" modified="2011-10-19" version="1" fragment="single">DALALLRQGIANNSLPIPTTDTDPSSQADSNVSLAKASYLLFNYSSQEDGPQHTAIPLNQQTRFVSESSGKRALDLRSVYFCWLNKDASVPDYVNATAQLNTELQQTGNNESITSLPFLERIDLNNWLSGEVAEHESEFIKSLDAKEASRDAALAAKVAQGGEDVEMRDAGLADDVKRREEEDRLREIYAAERKMGDHNTVLRGVKIQDFSGMRKYSALFLGKSKPGAPAPGSAPALNNNPALRPPIKPSNPNRRLEPIILLSSSFSSLLRMPNIKSFLNDGVYAPLEQSTESPSILHITRNLRTIHPGHATRFILVDDPSNFRPDYWSRVVAVFTTGQTWQFKGYKWTNPAELFSHALGVYVGWKGEVVPDTVKGWGRQVLSVQIDKGQNRWRDREVVEDIWSQIEGRMRAMGWGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD19</accession>
    <name>F9XD19_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_43512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851432.1">
        <property type="nucleotide sequence ID" value="XM_003851384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD19"/>
    <dbReference type="GeneID" id="13393670"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43512"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.233"/>
    <dbReference type="eggNOG" id="ENOG502SJM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD19"/>
    <dbReference type="OMA" id="FNIAYHV"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="467" mass="51568" checksum="8382EF5888E05D97" modified="2011-10-19" version="1">MSGENSDDTRKQKPWIMNAFAMASPGHLAPGLWRHPDQEPQTLEHWIKLAQELEEAKFHGIFFADVLGIYDVYGGNGPALSSGAQIPHIDVSYLVPALAYATKNISFGITASTSYEHPYTVARKWSTLDQLTNGRVGWNIVTSYLESAAKSFGLESTVDHDKRYQAAEEFMEVIYKLIEGSWDDDAVEANKTTGVYSNPSKVHAINHVGEYFKCRGPNLVQPTPQRTPFLLQAGASKAGKAFAASHAETMFLPGLVPEKTRAIVDDVKATLKAIGRPEDSVKFLPGIFICVDETDEKAQAKFQDLLQYVDLEGTASLFGGWTGTDLSKFSDDEDFSFNGPPAIVSMINAWTATVPGTKDQKWTKRHVLQQMAISGAHPRAIGSPQTVADIMQEWVDKAGVDGFNIGYATTPGTFRDVIKYLWPELKRRGVLQEEYAGSSMRENYLQDGKGPRVREGHPALKYRNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD44</accession>
    <name>F9XD44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HTR2402</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_104812</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851442.1">
        <property type="nucleotide sequence ID" value="XM_003851394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD44"/>
    <dbReference type="FunCoup" id="F9XD44">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD44"/>
    <dbReference type="GeneID" id="13393655"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104812"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.257"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="F9XD44"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP86418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="136" mass="15349" checksum="D1051E808E7064D7" modified="2011-10-19" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD83</accession>
    <name>F9XD83_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_73064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851865.1">
        <property type="nucleotide sequence ID" value="XM_003851817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD83"/>
    <dbReference type="FunCoup" id="F9XD83">
        <property type="interactions" value="1161"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XD83"/>
    <dbReference type="GeneID" id="13401527"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73064"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.298"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019858_1_2_1"/>
    <dbReference type="InParanoid" id="F9XD83"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="249"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="502" mass="56547" checksum="9FF1B361F8A53723" modified="2011-10-19" version="1">MADKMEVDAVNGEEKKEEETVQEVSPQRIIINNFALINSAVDSFDSRFTLRALRSISTLRKSSAFPEAIIHGIRTAYPNASNRGRQILEELLPEKHRSAQNGSAAKSTATEEQVHPEIWAYLGVLVQVYLYDAGEIETGAEFSENFVERIRSWNRRTLDQIGTKAYFYYALFHENLDPKPPSKQSHVIETRPKLLAALRSAVLRKDFDTQAAVTVLLLRNYISTADITQADLLVAQTQFPSSASNNQVCRYLYYLGRIRAIQLAYTQAHEHLESATRKSPTTGPAVGFYQQAMKLLIVVELLMGDIPERSVFRQPALEAALYPYFKLVQAVRVGDLQAFLKCVNVSEAQFRKDGTYTLILRLRQNVIKTGVRMLSLSYSRISLRDICTRLGVESEESAEYITAKAIRDGVIEASLDHQNGHMVTVPQKDAYSTTEPSEAFHARISALLGMRDECVMAMRYPMNKHRQEIAEAAKARDRERELAKEIVDGDIDDGDDEGFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDD9</accession>
    <name>F9XDD9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_109863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851795.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9XDD9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="13401561"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109863"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.352"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="F9XDD9"/>
    <dbReference type="OMA" id="FRCKSSK"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33135" checksum="B2270C93AD07CF5D" modified="2011-10-19" version="1">MLHARQDDGGLSEFEFYKYQPSLVAAIICVVAFFIITTIHIYQMFRTRTWFMIAFCIGGIFETVGYVGRAASAAQDADAYTLGPYIIQSILLLVAPALFAASIYMELARIVLLVDGDHALLIRRRWLTRIFVSGDVLSFLVQASGGGLLAASSDSVRTGENLILVGLALQIIIFGFFVIAGAIFHFRIRKAPTLKSQSLPYQKHMWSLYGVSILIFIRSIVRLIEYAQGYSGYILSREWYLYVFDALLMFAAMAIMSYIHPSEVKALIRGGGKAARNFIFFREVKEGGQVQMMQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDR9</accession>
    <name>F9XDR9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_26083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDR9"/>
    <dbReference type="STRING" id="336722.F9XDR9"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26083"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="InParanoid" id="F9XDR9"/>
    <dbReference type="OMA" id="FVICERK"/>
    <dbReference type="OrthoDB" id="3648641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="275" mass="29709" checksum="3F1F0F74520616EF" modified="2011-10-19" version="1" fragment="single">AFVAFTSGSTGTPKGIIQTHQGIVTVCQALANQLHVTSSSRVAQFHPYIFDVALMEIGMCLGTGATLCISKKKDMMLPLPGEVGSQLTAFGITHVTMSPTMLETMDPGDVPTVEVLSVMGESLGRHAVEQWASTASRTFYQLWGCTEATILQSITTAITATHAPRDVGQAIGDTCRLWIVDPANVNKLMAEAAAGELVVESRALARGYINQPEDTLRSFVERADWMDVASRGTLYKTGDLAQKEADGSITFLGRLDSQMNYHGERIELGEINFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDU9</accession>
    <name>F9XDU9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_43197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851761.1">
        <property type="nucleotide sequence ID" value="XM_003851713.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9XDU9">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDU9"/>
    <dbReference type="GeneID" id="13401715"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43197"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.531"/>
    <dbReference type="eggNOG" id="KOG1823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDU9"/>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Wittenberg A.H.J."/>
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                <person name="Hane J.K."/>
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        <source>
            <dbReference type="EMBL" id="EGP86966.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Van der Lee T.A.J."/>
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                <person name="Bristow J."/>
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                <person name="Ware S.B."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
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    <dbReference type="OMA" id="KYAWLPR"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="751" mass="84827" checksum="C1F9EE433BDDEC6C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFG7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="336722.F9XFG7"/>
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    <dbReference type="eggNOG" id="ENOG502R8UN">
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    <dbReference type="InParanoid" id="F9XFG7"/>
    <dbReference type="OMA" id="DFKVVFC"/>
    <dbReference type="OrthoDB" id="3838727at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="199" mass="21937" checksum="B95492D91ED93D65" modified="2011-10-19" version="1">MQLTTILLATFAALTTALPTSSLPTTQNLTARADDTFEILIINRCKWTKSFALYNIEQPSFTMVERSKPVNIPTNGQHTLRAPFHGLGYRLSGHAEWGTARQWEHQALFEFGFSSYMGVDGTAYNLSVMEGSDKDIGVRVWPIGNGKGSGQCPRKTCWPDNCPPSQGWTSPDQDKLGSPADTVCYKGKTGFRVVFCPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFH7</accession>
    <name>F9XFH7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFH7"/>
    <dbReference type="GeneID" id="13397689"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94850"/>
    <dbReference type="HOGENOM" id="CLU_1284185_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFH7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395624" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24137" checksum="1F306D642FC1D567" modified="2011-10-19" version="1">MSIFLLLVQLCAVIRPTRPKAQILARQDIDMLCSRTFMRSSFNSVRDSDIINSQHRHRRIRPLPYPSSRDRMNGSIHLRKMDAPSTLSTPVCTTMKAKIMTGSDRTAMQDGHHALKREEVVFQTPGGPMPDVFAISTLRSRRLKNSPDPAPMPPGMPTGVSECETDSYAAKMTEQLNKNPRCQTRSSAHPTMRATVVISEHAGIMHEPTDRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH21</accession>
    <name>F9XH21_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_95405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850241.1">
        <property type="nucleotide sequence ID" value="XM_003850193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH21"/>
    <dbReference type="FunCoup" id="F9XH21">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XH21"/>
    <dbReference type="GeneID" id="13394594"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95405"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.667"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_2_1"/>
    <dbReference type="InParanoid" id="F9XH21"/>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="138" mass="14832" checksum="1E0F88C40BC93F9C" modified="2011-10-19" version="1">MGKRKSSSKPQGPKKREALAVAFKCVFCNNESSVTVKIDKKQGVGNLSCKACNQNFQTSVNYLSVPVDVYSDWIDACDAVAKDTSDTRGPAPPSSSMRQPQPHPSARAGLAPGEKYTAEDEGFIDDDDADPEADFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHA4</accession>
    <name>F9XHA4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850229.1">
        <property type="nucleotide sequence ID" value="XM_003850181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHA4"/>
    <dbReference type="STRING" id="336722.F9XHA4"/>
    <dbReference type="GeneID" id="13394529"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28495"/>
    <dbReference type="eggNOG" id="ENOG502R8AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_6_2_1"/>
    <dbReference type="InParanoid" id="F9XHA4"/>
    <dbReference type="OMA" id="CEISAWP"/>
    <dbReference type="OrthoDB" id="3647231at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="123" mass="14409" checksum="D7532D6B63476BF2" modified="2011-10-19" version="1" fragment="single">FKHGPLRDSETQIRLIRLKPGRQDDNIELELSTWNFANAPEYHAISYTWGADVRRIIFINGLAHWVRHNCHYALMQARLHYPETYIWLDSICIDQGANKEKSHQVAMMKDIYVKADWVLACIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHF7</accession>
    <name>F9XHF7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_46276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003850426.1">
        <property type="nucleotide sequence ID" value="XM_003850378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHF7"/>
    <dbReference type="GeneID" id="13395004"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46276"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.287"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="F9XHF7"/>
    <dbReference type="OMA" id="AIFPWSS"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="559" mass="59860" checksum="6DC29309A3829037" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XII5</accession>
    <name>F9XII5_ZYMTI</name>
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        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Atr6</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_74970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="protein sequence ID" value="EGP85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13394735"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74970"/>
    <dbReference type="eggNOG" id="KOG0065">
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    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="F9XII5"/>
    <dbReference type="OMA" id="QYWSDQS"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1274"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1455"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="170"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="854"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1481" mass="164957" checksum="27240A2E4C07B372" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIM8</accession>
    <name>F9XIM8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850283.1">
        <property type="nucleotide sequence ID" value="XM_003850235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIM8"/>
    <dbReference type="STRING" id="336722.F9XIM8"/>
    <dbReference type="GeneID" id="13394711"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75046"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_988887_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIM8"/>
    <dbReference type="OMA" id="WEDSEPS"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="282" mass="30468" checksum="8E3F91FD8D8F972F" modified="2011-10-19" version="1" fragment="single">MIKNHYSRQIEGGRSDLEDAANNANVRRERGEDLGPPPTPTPIVKRKYDNPQQASTPRAIAPQKDAMDMDEPMSLSQAPMPKHNSPPQFPPKPRYVSSAQGTPVPAPRAIPGPMPPASNPHSSGNATPMQQPPQPHKQDWQSRVLGGQGSQSSPPNAPLDRDGRAPYFPHHRSSMMSSMNSRGNPSPPPHAMGHSRTSSMNSQQPAGSRDQRGAMGGPPPSSHLHNNPYGASHQPPPFSQAPPAQNRAVHSHNSSITGDPNMMPRFPSGPANDHSREEAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIR0</accession>
    <name>F9XIR0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_45910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850139.1">
        <property type="nucleotide sequence ID" value="XM_003850091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIR0"/>
    <dbReference type="GeneID" id="13394415"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45910"/>
    <dbReference type="HOGENOM" id="CLU_2910620_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIR0"/>
    <dbReference type="OrthoDB" id="10440785at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="7502" checksum="01E64C14CBD32999" modified="2011-10-19" version="1" fragment="single">FIEALTDIRSKTFTTYNVRKAFKSSGIMLVNIEVPYSFLRKRYSTEDKEYRLRIEELVNKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIR2</accession>
    <name>F9XIR2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850270.1">
        <property type="nucleotide sequence ID" value="XM_003850222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIR2"/>
    <dbReference type="GeneID" id="13394417"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95359"/>
    <dbReference type="HOGENOM" id="CLU_877746_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIR2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="317" mass="35721" checksum="760EFEA64387A579" modified="2011-10-19" version="1">MDCPPDHYSEDSDDPPIKARMKALRESTAELLQREAARYSSDELDKAYSSYLNEAGFQVALLQQGAMHGFMYRLFKAWPDTRIRYSQPPLERSSLDPNAARGRKYTNAHRPAARGPVVQSLLSPRIPHDDEETVAATLFPAAVADEYDEAQIIEGLNRGGVADFLAHATDPRVLQVRCPNTYYNGPWVSLNAIIPDRLWPNLQSIDLFGFECTEDKLVRFVTKCCATVSEFCVKCPLLTHGRWTSVFRRVAGMFRSFKSFGFEASLLTRDADDGRLKHVGMGNIYQPDLLVHRDLLYDFLRNGGPEPHVITSGYFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK03</accession>
    <name>F9XK03_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_75518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849385.1">
        <property type="nucleotide sequence ID" value="XM_003849337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK03"/>
    <dbReference type="GeneID" id="13399081"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75518"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.276"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_1"/>
    <dbReference type="InParanoid" id="F9XK03"/>
    <dbReference type="OMA" id="AWSFYLL"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="512" mass="56696" checksum="0E1BDB91D1F6494F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKU0</accession>
    <name>F9XKU0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_49006</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKU0"/>
    <dbReference type="GeneID" id="13398338"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49006"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="InParanoid" id="F9XKU0"/>
    <dbReference type="OMA" id="CISHIHF"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="308" mass="34178" checksum="B2A9967DD80DB3AE" modified="2011-10-19" version="1">MTFPLPPARENQVYVTVSPLAGGYITLADHFFVSPAEPNAARTVPSLSFLIKHPGPNKFSSKTSRPFHLMFDLGLRRSKDRYPSALQAHLKSREPHHLEPGVAAQLSAGGLDPGDVDMVILSHVHYDHHGDPEDFPNAQFRVGKGALDVLEHGLGAGGSHQHFVPGTLPSDRTQELSDPAVRGEWKSMGPFPATLDLFDDGSVFVIDMPGHLPGHVNLLCRTEGERWVMLCGDAFHDRRLLTGEKEIGTWEGEGGRRLCIHCDEEGARRSIGRLREWDRVTGEQCELVAAHEDAWWERNRDKQFPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLT6</accession>
    <name>F9XLT6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_76524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849055.1">
        <property type="nucleotide sequence ID" value="XM_003849007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLT6"/>
    <dbReference type="FunCoup" id="F9XLT6">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XLT6"/>
    <dbReference type="GeneID" id="13398452"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76524"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.430"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="InParanoid" id="F9XLT6"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="14">
        <location>
            <begin position="414"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="775" mass="89109" checksum="3B11C6190D610C51" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMW8</accession>
    <name>F9XMW8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">N-acetyltransferase ECO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_49783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848642.1">
        <property type="nucleotide sequence ID" value="XM_003848594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMW8"/>
    <dbReference type="FunCoup" id="F9XMW8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMW8"/>
    <dbReference type="GeneID" id="13396297"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49783"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_2_0_1"/>
    <dbReference type="InParanoid" id="F9XMW8"/>
    <dbReference type="OMA" id="WHVYEES"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="10">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="11">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP83618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27773" checksum="A29621E0A0E8F724" modified="2011-10-19" version="1">MIQTQMNLGQSIQTTCKQCGMEYVLSSAEDRNLHAKFHKQNSEGVEVGASFVDGTEAHKQFVGVAKRPADAVIVVDSSDKKTRQKKSQAVLEVVQRELGAVSIPEADVWEKPKDAASDSEPQYHSYLYVREGKCIGYLLTQSIAEAYTVLAKEQAEETKRKRLEHAARQPICLSKTRVPVVLGISRIWTSPMHRGQGIAMALLDTAVEGYNAHFGASRSKTQVAFSQPTESGAKLARKWTGRLFGWSVYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN50</accession>
    <name>F9XN50_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848373.1">
        <property type="nucleotide sequence ID" value="XM_003848325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN50"/>
    <dbReference type="GeneID" id="13396270"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96672"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.283"/>
    <dbReference type="HOGENOM" id="CLU_834726_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN50"/>
    <dbReference type="OrthoDB" id="10457742at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="333" mass="37282" checksum="2856089DA6F50074" modified="2011-10-19" version="1">MPSAKQTAPMDVNARPPMSWCVDCANNGLEFCDRQINTPCTQCTQHNNKPETVNPRVCTQAHPRAWPHPTKWQARQMERRMMRNLDGTGRVIGNVGKVIVDTRPPPAPQPQQPLRIQQPLRAQQTGNRRPALTRPLPSAHRPLPGSPYLPPATAPGYAGAPRYGYGHAPPPPPAQQQHRYGYGPPPHLHPDWAHFQPDWARQQYGHVQQPAATPQYPPSPPPLLPASPPPTAAEMLIRQQVEIAKLKEEAAEWKRQANARNAPKEVKQCDADRLPVESVKVKREREPEDDSTFEPASKDRRPNGVENRAASPKIKVEPGVEEQTDSRAHDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN74</accession>
    <name>F9XN74_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBPIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MgHop2p</name>
        <name evidence="8" type="ORF">MYCGRDRAFT_49688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848387.1">
        <property type="nucleotide sequence ID" value="XM_003848339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN74"/>
    <dbReference type="FunCoup" id="F9XN74">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN74"/>
    <dbReference type="GeneID" id="13396411"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49688"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.310"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_3_0_1"/>
    <dbReference type="InParanoid" id="F9XN74"/>
    <dbReference type="OMA" id="QKYHREW"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="214" mass="24391" checksum="FBD4FDE954D79FCA" modified="2011-10-19" version="1">MAPTKEKGEAKEPKLTPEQSAAAILTYLRKENRPYSATDISSNLHNRVTKTAAQKLLKDMHERKEIEGRASGKQIVYHVIQDEVPDDFLEKLAEMDREITRLREETVALKAEEKELKSSLRGDAARVPMPELKASVEALQAQKDEVEARLVKLRSGSLKPVSAEEREKIDVMYRKVGKVAKNRAKIRTELWAEVKGIVEKEKWEDLKETLGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNR2</accession>
    <name>F9XNR2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_111479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
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            <end position="312"/>
        </location>
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        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="312"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58542" checksum="4EF6A8249774727B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNU4</accession>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
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                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="71" mass="8315" checksum="07DB04AEBB7FA726" modified="2011-10-19" version="1" fragment="single">MAPLPPSDDYYIILEVESSATAEEITQSYRRLALKLHPDRNDRPNATQAFQKLGQAYETLKDDDERRKYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPP0</accession>
    <name>F9XPP0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_101835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847816.1">
        <property type="nucleotide sequence ID" value="XM_003847768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPP0"/>
    <dbReference type="GeneID" id="13401461"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101835"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.45"/>
    <dbReference type="eggNOG" id="ENOG502QQSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPP0"/>
    <dbReference type="OMA" id="CHNADLY"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390992" evidence="1">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="483" mass="53258" checksum="038801686D06EC0E" modified="2011-10-19" version="1">MKFSTIATLLPVLASAAKFSKEEYVSGKVHMKHMEAKEASWATKRAAGKFISKKWNGHKAAKVQCNKDGLAVAVKGDPLQTFKCKGIDMYDFKSHAEMGSPTGEGSGSWGWTYMGREFMAIGQSDGAAFVEISKSGSLVYLGRLPQQSTPIIWREIKVNGNYLIVGSEAVDHDIQIFDLRKLLTINPLQPKTFDPKTDLTGLFTDLPTGRSHNVVVNEELNYAVAVGAAPRTSACGGGLIFINLDDPSKPYSEGCAPQDGYVHDAQCIVYRGPDTRYNGKDICYGYNEDTLTIYDVTNKTGPQAAKVISRTPYVGATYTHQGWVNDPMWQTRLILDDEIDEEERSGPAADQFPVSYIFDITDLEKPVNTGFYKTKVKGIDHNQYIYDGLAYQSNYGAGLRVLDVSTIEEDSTGAGIEEVAFFDVYPEDDALPGGGIVDYVGTWSHYTFPSGWIVVNTIERGAFLLKMNGFKGRGFGKRHIKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPZ2</accession>
    <name>F9XPZ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_97358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847771.1">
        <property type="nucleotide sequence ID" value="XM_003847723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPZ2"/>
    <dbReference type="STRING" id="336722.F9XPZ2"/>
    <dbReference type="GeneID" id="13401368"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97358"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.157"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994129_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPZ2"/>
    <dbReference type="OMA" id="CEHESAF"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="284" mass="31988" checksum="BF878843D9E3E73F" modified="2011-10-19" version="1">MGRLAPISFRSMQARALCTLRYSISRLSISAEDLTLFTKTLILAKPWIGNSTALAVPWREVARPSRLRIGLFQEDPVYPVHPPVRRALRLAAQRLEATGHQIITPDQCPSLRKAVTILSRGFSLDTSHAAMRHLAEAGEEPILPLVKMAQSSQIEQREAGLEDVWRFRAERYEYREEWGTVWRENSLDILLCPGYQGVGARHDHVGVPFYSAVWNLLDFPASVVPFQKADRSVDTQEVPGYDPILVDGVPAHIQIVGWRFQDEEALSATEVISEALRDTVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ32</accession>
    <name>F9XQ32_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_77832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847594.1">
        <property type="nucleotide sequence ID" value="XM_003847546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ32"/>
    <dbReference type="FunCoup" id="F9XQ32">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ32"/>
    <dbReference type="GeneID" id="13401356"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77832"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.203"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="InParanoid" id="F9XQ32"/>
    <dbReference type="OMA" id="ETLIDWD"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
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    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
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        <property type="entry name" value="SI:CH1073-390K14.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
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        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="68"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
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            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
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            <name>FAD</name>
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            <position position="362"/>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="365"/>
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            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </feature>
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        <location>
            <begin position="463"/>
            <end position="465"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP82570.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="555" mass="63042" checksum="04AAC8BD442F6F25" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ54</accession>
    <name>F9XQ54_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-cytochrome b5 reductase 2</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_51378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
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    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003847690.1"/>
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    <dbReference type="STRING" id="336722.F9XQ54"/>
    <dbReference type="GeneID" id="13401350"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51378"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_13.227"/>
    <dbReference type="eggNOG" id="KOG0534">
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    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="InParanoid" id="F9XQ54"/>
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    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CBR-like"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
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            <name>FAD</name>
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        <ligand>
            <name>FAD</name>
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        <ligand>
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        </ligand>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="309" mass="33277" checksum="F99735DB268D5520" modified="2011-10-19" version="1">MASKVPQYSRTLPVLSSLAVFAIAGSTYANSRKPIQLDSASNPPTKAFTFPSGMLFSKRLTVTHSEQVNHDTKRVTFALPGEKSQVSGVPAGSAILTQHTPAGGWFPVFRPYTPISDPNEPGTLQLLVKQYPNGKASSHIHSLQPGDQLTVRGPIPGYSYTPSSRPQSRDLILVAGGAGITPIYSLARGILQDANDNTRIQLLWGINGTRDIVLKSELEALGRTHPDRLQVTYAVSGADCALENEKYKKGYINKSMLQEAFAMCENSSWGDAKGIKVWLCGPPTMESALTGKDGALAELGVIGKELHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQG3</accession>
    <name>F9XQG3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_31208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003847614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQG3"/>
    <dbReference type="STRING" id="336722.F9XQG3"/>
    <dbReference type="GeneID" id="13401065"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31208"/>
    <dbReference type="HOGENOM" id="CLU_013137_21_5_1"/>
    <dbReference type="InParanoid" id="F9XQG3"/>
    <dbReference type="OMA" id="GHIECEL"/>
    <dbReference type="OrthoDB" id="3642276at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="61" mass="7124" checksum="5B30F5A004A5255D" modified="2011-10-19" version="1" fragment="single">ALETTQVTEEDLEGEDNRCGMCHEDYAVGEEWSKLPCTHRFHKDCVTPWLNEYSQDGRCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQS0</accession>
    <name>F9XQS0_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_51651</name>
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    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847461.1">
        <property type="nucleotide sequence ID" value="XM_003847413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQS0"/>
    <dbReference type="STRING" id="336722.F9XQS0"/>
    <dbReference type="GeneID" id="13400374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51651"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_0_2_1"/>
    <dbReference type="InParanoid" id="F9XQS0"/>
    <dbReference type="OMA" id="NTMMMFF"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="789" mass="88013" checksum="9EC2DEF7BA7D997F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR78</accession>
    <name>F9XR78_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847235.1">
        <property type="nucleotide sequence ID" value="XM_003847187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR78"/>
    <dbReference type="GeneID" id="13399887"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97737"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.51"/>
    <dbReference type="HOGENOM" id="CLU_1273154_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR78"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="217" mass="24116" checksum="2ED3DDB5EB540822" modified="2011-10-19" version="1">MSQVPLSERVNEGRRVENDELTRDVAGSRGGDMAEGAWWMGRDRGGNGMRVTVMMRETEQGSLSRGHSYRLSGGDTSVEDLTTIRRRRKYYRARKVQQGGSESRQANYWSRFVDTWTKPERSDRASIDRRAQLWLSSCPELSDNVLGSSCEEAPVVMKHADPANVDTVTGGAALSPAAGNFRKTASASTEQLLHLLRPLVSDSQNPMAGQQTWNRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRV6</accession>
    <name>F9XRV6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857180.1">
        <property type="nucleotide sequence ID" value="XM_003857132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWP8"/>
    <dbReference type="GeneID" id="13395119"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27122"/>
    <dbReference type="eggNOG" id="ENOG502RZTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065416_1_0_1"/>
    <dbReference type="InParanoid" id="F9WWP8"/>
    <dbReference type="OMA" id="HDNACGP"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP92156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="208" mass="22474" checksum="321BFDDBE3B189BD" modified="2011-10-19" version="1" fragment="single">TDWETMAKMYKKLTVGVSSKPITAMLNMANAYLPFSEASGIHDNGCGPGNVIERIVSDYGGVIPSTASLSASDFAPAMVEKARGLKTEALEKDPSSPWGRVDVKVGDAMNLQGVKDGSLSHVTAGWVYFLTPDPMKCLKESKRVLKDGGVLSCSSWQSSQWMDTMKIPAKVRPDLQHPSVPTEWASAPALKAELEKAGFRDVQAQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX22</accession>
    <name>F9WX22_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_31641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856695.1">
        <property type="nucleotide sequence ID" value="XM_003856647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX22"/>
    <dbReference type="GeneID" id="13398706"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31641"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035633_0_0_1"/>
    <dbReference type="InParanoid" id="F9WX22"/>
    <dbReference type="OMA" id="AWGFEDP"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="257" mass="28123" checksum="EC0FDCCC414B4094" modified="2011-10-19" version="1">MTRVSLLTHISARAEEIARDPSVFLTAAILKAYVELQSLLHQPSSFPDIFNLYANKPIPSLSNGNLAFSPSSPNKVSAAIDPNTANLALASATSAHDLGLAIDIITTSFCTKAFKRAKFLRRAALPMFGLGIAPIAAYSLSNSYSNWQQTMDAQMATHIAFAGIMTYVSAVSMVGYVAVTTANDQMDRVTWAQGVPLWERWVREEERAAIDSVAQAWGFTEAEKRGDEEGEEWDALREWVGVRGMVLDKVSLMEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WX92</accession>
    <name>F9WX92_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_98910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856809.1">
        <property type="nucleotide sequence ID" value="XM_003856761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WX92"/>
    <dbReference type="FunCoup" id="F9WX92">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WX92"/>
    <dbReference type="GeneID" id="13398367"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98910"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014926_1_0_1"/>
    <dbReference type="InParanoid" id="F9WX92"/>
    <dbReference type="OMA" id="AFHSDIY"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="663" mass="73858" checksum="853B2167F8A02421" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXA5</accession>
    <name>F9WXA5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_67605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="SIYACFY"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="Gryzun"/>
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        <property type="entry name" value="TPC11"/>
    </dbReference>
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        <property type="entry name" value="FOIE GRAS"/>
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    </dbReference>
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    </dbReference>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ66</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </source>
    </evidence>
    <sequence length="178" mass="19384" checksum="45F3BA7CE8E50609" modified="2011-10-19" version="1">MNRPRNHQQRPSRDQQRGGRRGPSSSSGVSVPTVQQVRPGAAVSIVLKQDQPTGREVQGTVQDLLTRGDHPRGIKVRLTDGRVGRVQRMAAANYARSQQLPTTNTTAWPGLREISGDDHLNGPPNRTLADFLPTSTELESQPETAAATFATATAKCPICNIFEGDEIAVSRHVEDHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZD3</accession>
    <name>F9WZD3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_107351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857245.1">
        <property type="nucleotide sequence ID" value="XM_003857197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZD3"/>
    <dbReference type="GeneID" id="13399184"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107351"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_3_0_1"/>
    <dbReference type="InParanoid" id="F9WZD3"/>
    <dbReference type="OMA" id="HICSHAS"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="334" mass="37800" checksum="C04DED2CD9461FBA" modified="2011-10-19" version="1">MFAVWDDDKNPSCASANISDPGFRGYLYLDLFYRPPFKSTDGGFENMFSPGYRKPDGTLHYPSVRVITNFIRSENEALKPSLIKYSDLGVVFHELGHGMHDLLSVTNFTRTHGTFGVPVDFVEFPAQFMENYPRRPEAVKRIARHWSSLSPQAAEAWRKEQSDPNAPLPPATLPDDIAANVVSTSLVRRSLDQMRLVAFSTNDQQVFQATSIDEINSTDYVAIFNDKFRNLTGLEDPSDLGQGDRWGYPALSFTSYVNQYGGSLYTYLWCQSYAEDVFATKFAADPFNSDEGMRYRTQVLQYGGARDPAELLREYLGRDPNLEAFIKFANGQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZU8</accession>
    <name>F9WZU8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857588.1">
        <property type="nucleotide sequence ID" value="XM_003857540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZU8"/>
    <dbReference type="GeneID" id="13394313"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102173"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="InParanoid" id="F9WZU8"/>
    <dbReference type="OMA" id="WMSDIPQ"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="352" mass="38541" checksum="F6B309E85C7DFABE" modified="2011-10-19" version="1">MVQNKALIFAKVPSGWPVPGQDLTIESTEFDTEQAPPQGGFTAKVHYVSFDPYQRGRMRAPESKSYSPPFELGKPIDNSAILSVIKSDNEKFKEGSLVHAGRHATEEYSVITKEAADSANYNPLNNQYNLDPKLFIGALGMPGLTAYSSFYEIGQPKKGETIFISAASGAVGQIVGQLAKHEGLKVIGSVGDDKKLDFITKQLGFDGGFNYKTEKPMDALKRLAPDGIDIYYENVGGEQLDAAIQNANNFARIIACGMVSQYNLKPEEAYGVKSLMQVVAKRLKMQGFIVMDENMGPKYWKQHQENVQKWLHDGSFKAEMSTTVGIDNAAEGLIGMLAGKNFGKAVLEVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X016</accession>
    <name>F9X016_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_30209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
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    <dbReference type="MEROPS" id="C13.005"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_30209"/>
    <dbReference type="eggNOG" id="KOG1349">
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPI_transamidase"/>
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    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01650">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
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            <position position="155"/>
        </location>
    </feature>
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        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91154.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36000" checksum="40339713650BA868" modified="2011-10-19" version="1" fragment="single">LLSLPTALLALLAALDVSSATHTSNWAVLVSTSRFWFNYRHLANTLSLYRTVKRLGIPDSQIILMLPDDMACNPRNSFPGSVFNDKSRQLDLYDDKSTMENMAGMGGIEVDYRGNEVTVENFIRLLTDRWPASHPTSKRLMTDDRSNILIYMTGHGGNEFLKFQDSEEISSFDLADAFEQMWEKKRYHELLFMIDTCQANTMYPAFYTPNIIATGSSAKDQSSYSHHADQDVGVAVIDRWTYYNLEFLETRLNSTSADTRLGELFDSYTFEKVHSDAGVRYDLFPGGEPAVRDRRVLDFFGSVQGVEVDASHENASND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X027</accession>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X027"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83763"/>
    <dbReference type="HOGENOM" id="CLU_2905886_0_0_1"/>
    <dbReference type="InParanoid" id="F9X027"/>
    <dbReference type="Proteomes" id="UP000008062">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="62" mass="6985" checksum="55EC4462CE3E3DFC" modified="2011-10-19" version="1">MAIGKDTRSNTTHAFASLTAISHNTTGHKIINWPLMARNTSDQRRNFTSSLLSNVTDREHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0B9</accession>
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        <submittedName>
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    <organism evidence="1 2">
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856400.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9X0B9"/>
    <dbReference type="GeneID" id="13395081"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66594"/>
    <dbReference type="eggNOG" id="ENOG502QVHF">
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    </dbReference>
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    <dbReference type="OMA" id="DLRWTEP"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="558" mass="63878" checksum="DC71444AA24E936D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0J4</accession>
    <name>F9X0J4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_26915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0J4"/>
    <dbReference type="STRING" id="336722.F9X0J4"/>
    <dbReference type="GeneID" id="13398063"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26915"/>
    <dbReference type="eggNOG" id="KOG4843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072825_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0J4"/>
    <dbReference type="OMA" id="DSMAHRT"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="252" mass="27949" checksum="682C5B8403B349CD" modified="2011-10-19" version="1" fragment="single">HHHHHHHAQAVGHHHHHAPRAQPPPRMPSTTVVSKKVLEACAGKPRRHLGSQLYTTEVSLAPAAETPLDAKIKFSSKSKPIPVFEGKENSTFTVRVPRYFLAPSEAGNSSLEEICKRRQLWGTEVYTDDSDVVAAAIHSGWLKGDFGDLNHDLQQASENGPEQDTSEATLLTLTERPSKPVQVPEGFDAHITVLVLPPLEKYAATSQHHIWSRDWAKTHDGMSFMIHSIEFVDEGASSRFAERGAAARKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0S8</accession>
    <name>F9X0S8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_90170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856754.1">
        <property type="nucleotide sequence ID" value="XM_003856706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0S8"/>
    <dbReference type="GeneID" id="13398561"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90170"/>
    <dbReference type="eggNOG" id="ENOG502SNNR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008809_1_1_1"/>
    <dbReference type="InParanoid" id="F9X0S8"/>
    <dbReference type="OMA" id="TIINWEN"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391056" evidence="3">
        <location>
            <begin position="21"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="688" mass="74895" checksum="6EF3DA42D92DA7DC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1I2</accession>
    <name>F9X1I2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MYCGRDRAFT_102943</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856771.1">
        <property type="nucleotide sequence ID" value="XM_003856723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1I2"/>
    <dbReference type="FunCoup" id="F9X1I2">
        <property type="interactions" value="1155"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1I2"/>
    <dbReference type="GeneID" id="13398540"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102943"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1977"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="F9X1I2"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <source>
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    <sequence length="183" mass="20993" checksum="6134CCF991B26D10" modified="2011-10-19" version="1">MGLTFSKLFDRLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLSNSLRKAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1J6</accession>
    <name>F9X1J6_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Signal peptide-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">MYCGRDRAFT_90213</name>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="692"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="435"/>
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            <end position="577"/>
        </location>
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        </source>
    </evidence>
    <sequence length="692" mass="76842" checksum="66EF0FF4F6619018" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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    </gene>
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        <name type="synonym">Septoria tritici</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
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                <person name="Schouten H.J."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2112"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="335" mass="37902" checksum="41EF0DF8CABA4110" modified="2011-10-19" version="1">MLPVRTIKPKTARTKRYLDNKGPQIVENPRTTLFLRYTSCSELTQLVIRDLVTLKKPLCIKFDKKNTVHPFEDASSFEFFADKNDASLLVYGSHSKKRPHALTVARMFDFKMLDMIELLVDPDTLRTISQFKGSKVAFGLKPLISFSGSAFESPVPNAYTLAKSIFMDLFKGPDASAVDVEGLQYIMSFSVDEEESAEVKPKIHMRCYLLRTKKMPNSTLPKVEVEEMGPRIDFRVGRIHEADPGMWKEAMRRPKMLEPKTKKNIETDLMGDKVGRIHMGKQDLSQLQTRKMKGLKRSRDVVDEDFDDDAAMDGAVDEADGGVAVAMEKKAKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X202</accession>
    <name>F9X202_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_67718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854712.1">
        <property type="nucleotide sequence ID" value="XM_003854664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X202"/>
    <dbReference type="FunCoup" id="F9X202">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="GeneID" id="13395881"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67718"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.51"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="InParanoid" id="F9X202"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44900" checksum="889E9F76F3F19D3A" modified="2011-10-19" version="1">MSSEESSAVPPAQKGSWTGFLKQLSSFNGDLSAMTAPAWIVSNTSLTEYAAYWAEMPQLLVAPAAEKDPQKRMALVLKWFLSTLKSQYASRNEKLGSEKKPLNPFLGELFLGKWEDASGETQLVSEQVSHHPPVTAYSIWNNKHGVRLQGYNAQKASFGRTIHVRQVGHCVLHLDQWNEDYVVTLPALHIEGLIRGSPYVELNKSSYIVSSSGYASRIDYSGAGWVSGTKNSVTATVYPHGKEKSKSSVLFTAEGSWTDTITFKDSSKNVVYTLDTKKEPKSTLQVRDIANQDPLESRRAWLKVSEAIQKGDMNLTSQEKTKIEEFQRAQRKKEASEGREWERTFFCKANGLPTFEKLIKEVPHGSLESDQTGGVWVFDENKAKNAQPPYNPLSTELQGGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9X275</accession>
    <name>F9X275_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_68234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855604.1">
        <property type="nucleotide sequence ID" value="XM_003855556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X275"/>
    <dbReference type="STRING" id="336722.F9X275"/>
    <dbReference type="GeneID" id="13403544"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68234"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.476"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="InParanoid" id="F9X275"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="515" mass="58128" checksum="9174EB736578403B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2A3</accession>
    <name>F9X2A3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_90699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855585.1">
        <property type="nucleotide sequence ID" value="XM_003855537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2A3"/>
    <dbReference type="GeneID" id="13399402"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90699"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.509"/>
    <dbReference type="eggNOG" id="ENOG502RM9V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136885_3_0_1"/>
    <dbReference type="InParanoid" id="F9X2A3"/>
    <dbReference type="OMA" id="FRGECHQ"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389968" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="153" mass="16580" checksum="47296301928706E9" modified="2011-10-19" version="1">MPSFTTILTLLAATAITFTTALPSPHLFTPRAPTNITDLNAGVNICTEPDFGGECYHSSWPKNTCIDLRGYAGVTQTFLPDTGFDCLLMQNKCDASVPFADISSDETEIARDLSGLKWIGNATSYICFSEVMAAKRFIRISRLKASGGMVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X354</accession>
    <name>F9X354_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein, RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_84836</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855135.1">
        <property type="nucleotide sequence ID" value="XM_003855087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X354"/>
    <dbReference type="FunCoup" id="F9X354">
        <property type="interactions" value="992"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X354"/>
    <dbReference type="GeneID" id="13400740"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84836"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="F9X354"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="468"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="861"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="957"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125455" checksum="3703903241E383B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3D9</accession>
    <name>HCS1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxymethylglutaryl-CoA synthase MYCGRDRAFT_54740</fullName>
            <shortName evidence="8">HMG-CoA synthase MYCGRDRAFT_54740</shortName>
            <ecNumber evidence="10">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-hydroxy-3-methylglutaryl coenzyme A synthase MYCGRDRAFT_54740</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ferrichrome A-like siderophore biosynthesis protein MYCGRDRAFT_54740</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ERG13</name>
        <name type="ORF">MYCGRDRAFT_54740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="631" last="631">
            <title>In silico prediction and characterization of secondary metabolite biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.</title>
            <authorList>
                <person name="Cairns T."/>
                <person name="Meyer V."/>
            </authorList>
            <dbReference type="PubMed" id="28818040"/>
            <dbReference type="DOI" id="10.1186/s12864-017-3969-y"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 10">Hydroxymethylglutaryl-CoA synthase involved in the biosynthesis of a ferrichrome A-like siderophors which may contribute to organismal virulence (Probable). The first step of siderophore biosynthesis is performed by the HMG-CoA synthase (HMGS) MYCGRDRAFT_54740 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (By similarity). The enoyl-CoA isomerase/hydratase MYCGRDRAFT_76805 then catalyzes the conversion of HMG-CoA to methylglutaconyl-CoA (By similarity). The acyltransferase MYCGRDRAFT_85486 then fuses methylglutaconyl-CoA with hydroxyornithine to yield methylglutaconyl hydroxyornithine (By similarity). Methylglutaconyl hydroxyornithine is then available for use by the nonribosomal peptide synthetase NRPS2 to generate the ferrichrome A-like siderophore.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="10"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855758.1">
        <property type="nucleotide sequence ID" value="XM_003855710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D9"/>
    <dbReference type="SMR" id="F9X3D9"/>
    <dbReference type="FunCoup" id="F9X3D9">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3D9"/>
    <dbReference type="EnsemblFungi" id="Mycgr3T54740">
        <property type="protein sequence ID" value="Mycgr3P54740"/>
        <property type="gene ID" value="Mycgr3G54740"/>
    </dbReference>
    <dbReference type="GeneID" id="13403698"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_54740"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.154"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="InParanoid" id="F9X3D9"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000451097" description="Hydroxymethylglutaryl-CoA synthase MYCGRDRAFT_54740">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P54868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4P3F1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4PEM9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q4PEN0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q4PEN1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="28818040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP90734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="460" mass="51028" checksum="1FF81541C1785C5E" modified="2011-10-19" version="1">MAARPNNIGIKAIELYFPSQCVDQAELEKFDGVSAGKYTIGLGQTRMSFCDDREDIYSLTLTTVSSLLRKYNIDPKSIGRLEVGTETLLDKSKSCKTVLMQLFEPCGNTNIEGVDTVNACYGGTNALFNTLNWMESSAWDGRNAIVVAGDIALYKKGNARPTGGAGCVAMLIGPDAPLVIEPGLRGSFVKHAYDFYKADLTSEYPLVDGQYSIKCYTEAVDKCYEAYNGREKTLKSQANGHSNGVDAAQEAPLDRFDYMCFHAPTCKLVSKSYARLLYNDYLADPTNELFKEVPAELKDLSYEASITDKTVEKTFMGLAKKRFAQRVQPSIQVPTMCGNMYCASVYASLVSLISNVSSADFQGKRVGIFSYGSGLASSLFSLKVKGSTEEITKNLNLQERLDARRVVAPEVYDEMCNLREKAHLQKDFKPKGSVDTILPNTYYLTNVDDMFRREYEVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3Q6</accession>
    <name>F9X3Q6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_84646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGP89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3Q6"/>
    <dbReference type="STRING" id="336722.F9X3Q6"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_84646"/>
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    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="InParanoid" id="F9X3Q6"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="77393" checksum="7E0EE3DF870B572A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X557</accession>
    <name>F9X557_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_85206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003853793.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9X557">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X557"/>
    <dbReference type="GeneID" id="13395595"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_85206"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.541"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="InParanoid" id="F9X557"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="346" mass="37875" checksum="4EAAB3B6442FFBCB" modified="2011-10-19" version="1">MTSSFVPRAVFPTLDSLPRSYYLGHHAAGLAKMKTMLGQIDLVVECRDYRIPLTSRNPMFENSLGGRERMIIYTKKDLGSKGAGMEDTKRHNLIQQWHSPSQVIFSDHKNQKDVRYILDAIKERSRLRGGLTGAHMMVVGMPNVGKSSLLNALRKEGVGKGKAAYTGAQPGITRKIGTGVKIVDGDNDGGAGGVYLLDTPGVFMPYVPDADAMLKLALCGSVKDTVIPAFNLADYLLFHVNLVDPKVYSEYTAPTNDAMVLLDAMARKTGRLQKGGVPDLESTALWMIQRWRTGHFGAFLLDEVSEESLQRYSMGSSGLPSLNQARKAGKEASRARQKARRAGNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5F6</accession>
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        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_69233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853630.1">
        <property type="nucleotide sequence ID" value="XM_003853582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5F6"/>
    <dbReference type="GeneID" id="13400884"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69233"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_3_1_1"/>
    <dbReference type="InParanoid" id="F9X5F6"/>
    <dbReference type="OMA" id="MHRIHSW"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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        </location>
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            <begin position="1"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="808" mass="86451" checksum="AABD7CE9FE2D7E38" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X692</accession>
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        </recommendedName>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Lindquist E."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP89359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="224" mass="24249" checksum="CF8B5EB4952FA0E5" modified="2011-10-19" version="1">MSAWGTASTLRMITGASSTSSTNVLFYTWIANAPQLAISVLYVAVNNYMTRLCSSHEWNRVSKSRKALRVTKPVAGQRSSHFLSLPYRWAVPLTVASGFMHWLLSQSIFLARLETLDGRGNPRPDESLCTCGYSTLSLMVLLGVLSLEALCTAASSLGGIKERLPVAANCSLVISAACHPPPEDVDAYKKPVQWGVVKPRFDGAGHCTITSEGVRKPEVAKSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6I7</accession>
    <name>F9X6I7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_38945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6I7"/>
    <dbReference type="GeneID" id="13404410"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38945"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="F9X6I7"/>
    <dbReference type="OMA" id="MRMAIWH"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP89047.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53352" checksum="4C02BBFF286BA893" modified="2011-10-19" version="1">MIETIETVVTPAAIQSQFPTLINLDAEEMAALEKRLIKRLDWRLLPTITIMFLMNYLDRINVSNARLAGLQDDLGMTDTVWNAGISTFYVGYLVGQLPGNLWLAKVRPSILLPSMMIAWSICTICMPAVTNGAGFCLIRFCTGLAEAPFFPGITLMTSSWYNKHESPMRMAVWHAGNTISNIISGFLAAGILYKMGDVAGVHSWQWFFIIEGGVSILVAIVAFFLLPDWPENTRWLKQDESEMAQYRSLMSNGGKREEVGGTWDGLKEAVKDPFTWMFCAMHFSLINAQSFKDFFPSIVKTFGFGELETYLVQAPPYAIAYLVACLAAYSSGRFQESTYHIVVPIAFSAIGCSILISTLNVGARYFGVILLVSGTYSGLNLQLSWETTLVPAPRSKKAALVAIANCVSQCSHWFSPHFFPTSQEPFYRLGGGLILFGCLSTAGLCWLIKWWANRLNKKLDQAEGWTEHTGAERGWRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6U0</accession>
    <name>F9X6U0_ZYMTI</name>
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            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">MYCGRDRAFT_85141</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="395"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="767"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="807"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="849"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="889"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110695" checksum="F49830BC0479626C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X1</accession>
    <name>F9X6X1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_99605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003854307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X1"/>
    <dbReference type="FunCoup" id="F9X6X1">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X6X1"/>
    <dbReference type="GeneID" id="13395542"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99605"/>
    <dbReference type="eggNOG" id="KOG3694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001013_1_1_1"/>
    <dbReference type="InParanoid" id="F9X6X1"/>
    <dbReference type="OMA" id="EIRIHAT"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11627">
        <property type="entry name" value="HR1_Ste20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
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        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="626"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138180" checksum="C177F30DB1AAA248" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6X9</accession>
    <name>F9X6X9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PATPB2401</name>
        <name evidence="12" type="ORF">MYCGRDRAFT_99610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853920.1">
        <property type="nucleotide sequence ID" value="XM_003853872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6X9"/>
    <dbReference type="FunCoup" id="F9X6X9">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9X6X9"/>
    <dbReference type="GeneID" id="13395538"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99610"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.688"/>
    <dbReference type="eggNOG" id="KOG0728">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_1_1"/>
    <dbReference type="InParanoid" id="F9X6X9"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="389" mass="43323" checksum="65BDC7DC334E323A" modified="2011-10-19" version="1">MALDTFFNNKIESMKLEIIQGQAVLRRLEAQRNEYNSRVRLLREELGLLQQPGSYVGEVVKVMGTKKVLVKVHPEGKYVVDVADSIDISKLTAGKRVTLLSDSYKLSSLLPSSVDPLVSLMMVEKVPDSTYDMIGGLDEQIKQIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPTTEARADILRIHSRSMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMFALRERRVHVTQEDFDLATAKVLNRHDDKEMSLSKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6Y7</accession>
    <name>F9X6Y7_ZYMTI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6Y7"/>
    <dbReference type="GeneID" id="13395532"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103805"/>
    <dbReference type="HOGENOM" id="CLU_1826830_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6Y7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="141" mass="15982" checksum="AE69AF1AAB097FAF" modified="2011-10-19" version="1">MWSEHDYNMMEDSRLEFRTDPHCLQYPRHWPEAVSPPIRYAGNLISAVWALWVVEDARKVACTFETMVALCWLYSMDKGGGLGPPRVNGVGLLCCVRVTWGLECVRRRISCSRVRSTADLVANICCAMQRCSASFPHRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X705</accession>
    <name>F9X705_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-coumarate-CoA ligase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_91866</name>
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    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854340.1">
        <property type="nucleotide sequence ID" value="XM_003854292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X705"/>
    <dbReference type="STRING" id="336722.F9X705"/>
    <dbReference type="GeneID" id="13395526"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91866"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="F9X705"/>
    <dbReference type="OMA" id="AWPNTDF"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="489"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66293" checksum="C782CEE63560F9BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7J9</accession>
    <name>F9X7J9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_56278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854587.1">
        <property type="nucleotide sequence ID" value="XM_003854539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7J9"/>
    <dbReference type="FunCoup" id="F9X7J9">
        <property type="interactions" value="1280"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7J9"/>
    <dbReference type="GeneID" id="13395774"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56278"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.179"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7J9"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119397" checksum="DA1F416C6BE4ED23" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7M5</accession>
    <name>F9X7M5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MYCGRDRAFT_103595</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854570.1">
        <property type="nucleotide sequence ID" value="XM_003854522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7M5"/>
    <dbReference type="STRING" id="336722.F9X7M5"/>
    <dbReference type="GeneID" id="13395757"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103595"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.207"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116822_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7M5"/>
    <dbReference type="OMA" id="MKRQTIQ"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP89546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="156" mass="16380" checksum="8923F53167A4A732" modified="2011-10-19" version="1">MASSLRMAAPKMASLAAQSSVKVARPMMKPAQLNKFARAYSGVAARQTSAFNTMKRTSTLMNSARTQVSTQAKRAYSSEMANALVQVSQNIGMGSAAIGLGGAGIGIGLVFAALLQAVARNPSLRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7S0</accession>
    <name>F9X7S0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_56657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853805.1">
        <property type="nucleotide sequence ID" value="XM_003853757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7S0"/>
    <dbReference type="FunCoup" id="F9X7S0">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7S0"/>
    <dbReference type="GeneID" id="13395642"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_56657"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.456"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="InParanoid" id="F9X7S0"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34437" checksum="B7E37717DADB87C4" modified="2011-10-19" version="1">MSAKSTAGPGGRKPASAATNLIAGGGAGMMEALACHPLDTIKVRMQLSRRKAGIKRRGFIKTGMEIAKKETPLGLYKGLGAVLTGIVPKMAIRFTSYEWYKQMLADENGKVKGSGNFLAGLAAGVTEAVAVVCPMEVVKIRLQAQHHSMADPLDLPKYRNAAHACYTVIKEEGFGALYRGVSLTALRQGTNQAANFTAYTEIKQIVQERAVDPQAPLPAYTTAAIGLISGAVGPFCNAPIDTIKTRLQKTPAEPGQTALGRITAIANHMFKQEGARAFWMGITPRVARVAPGQAVTFAVYEYLKDILEKGREMIPADKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X882</accession>
    <name>F9X882_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_70695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852838.1">
        <property type="nucleotide sequence ID" value="XM_003852790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X882"/>
    <dbReference type="FunCoup" id="F9X882">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X882"/>
    <dbReference type="GeneID" id="13400688"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70695"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="InParanoid" id="F9X882"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="338" mass="36934" checksum="1CAEC166FB0899A0" modified="2011-10-19" version="1">MSKGQTIRDCSHAGSWYSDSSSKLNAELDGWLAAVDAPVTCIGPRSEGEQVQQLPVPGARMIIAPHAGYSYSGPAAAWAYKAWDVSKANRKKVFLLGPSHHHYLTKAALSRCTQYATPIGNLTVDRETTAELHATGVFEWMSHSVDEQEHSLEMHLPYIYKMLSRTFGEDSAHFPPLVPLMIGNTSPSTEKALGRRLAPYLADPSNAFVISSDFAHWGLRFRYTYYRPSTGTAVDLTSSSRSPKEPAIHDSIKTVDFESMGACESGSHDEWLGQLEDTGNTVCGRHPIGVMMAAVEEVRKGAASQGTGAFKFVRYERSSEVKRVSDSSVSYASAFACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9K0</accession>
    <name>F9X9K0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_92517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88418.1"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
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                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853184.1">
        <property type="nucleotide sequence ID" value="XM_003853136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9T7"/>
    <dbReference type="FunCoup" id="F9X9T7">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9T7"/>
    <dbReference type="GeneID" id="13399548"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40375"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.882"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="InParanoid" id="F9X9T7"/>
    <dbReference type="OMA" id="RHLFHYG"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="237" mass="25622" checksum="FEB55BE102C8D41A" modified="2011-10-19" version="1">MAPLRTLSAKAAAALDEELMSTGAFSLDQLMELAGLSVSQALYTLSPPTKSPRILIACGPGNNGGDGLVAARHLHHFGYKPTMYYPKVGKNELYSRLRKQLEQLRVPFTDDFQSALSSSDFVIDAVFGFSFSGEVREPFPAVIRALAESKVPVLAVDAPSSWDIETGPQEEGPGKGYMPTALISLTAPKPLVKWFTGRHFVGGRFVGKEVAERFGFDVPEYRGGEQVVEVEGGGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9W3</accession>
    <name>F9X9W3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_92233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852797.1">
        <property type="nucleotide sequence ID" value="XM_003852749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9W3"/>
    <dbReference type="FunCoup" id="F9X9W3">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9W3"/>
    <dbReference type="GeneID" id="13397118"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92233"/>
    <dbReference type="eggNOG" id="KOG0421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_9_1_1"/>
    <dbReference type="InParanoid" id="F9X9W3"/>
    <dbReference type="OMA" id="PKDNHAV"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="166" mass="18195" checksum="A4D874EDE8B1E062" modified="2011-10-19" version="1">MTSTNTSASLIKRLQSELMSLMMSPTPGISAFPSGADMTKWNATMEGPTETPYEGLTLKLKISFPSNYPMSPPQILFRTPIYHPNVDMSGRICLDILKEAGPAEGAWSAALPTSSVLLSIQSLLGEPNNSSPLNGEAALMWDRDMVEFKRKVLARHVVPELLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA17</accession>
    <name>F9XA17_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_71423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <location>
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        </location>
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            <end position="149"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Kilian A."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
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    <sequence length="868" mass="98055" checksum="A593CE86E3ABF751" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC24</accession>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 115943 / IPO323</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <begin position="1"/>
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        <source>
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    <sequence length="249" mass="28229" checksum="0AFA23144870F6CA" modified="2011-10-19" version="1">MSLQTDCEVSKPHNAERPPYPIGVPLKFDESGVAQRYPGNTTVCHLASDSQLVAGLRKVYDTIKSHPTLGEKIRLLPAASWHMTVFDGVRETECEVGMWPVGMVKKPLPESTKDFSQRLRKFGMQLETEGLAPPYKMKVLDFDAAVVGIGLHVEGATPEEEKRMRRLRDRLASVLGFRAPNHEVYPFHISVAYLLRYIEGDDRIELNKVLDSLLPEIQMDFELGAVEFCTFENMLEYPRLFYLGEPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XC77</accession>
    <name>F9XC77_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_93207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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    </organism>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003852592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XC77"/>
    <dbReference type="FunCoup" id="F9XC77">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XC77"/>
    <dbReference type="GeneID" id="13396963"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93207"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="InParanoid" id="F9XC77"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="234" mass="25729" checksum="109E1F395F2A835C" modified="2011-10-19" version="1">MAPIDDIKTNCRKVMCIGRNYADHVTELNNQRPKQPFFFLKPPSSILTPSEGPILRPAGVNLHFEVELGVVIGKTVRDLDENDEAAWQDAIGSYILGIDMTGRNVQDEAKKKGLPWSIAKGFDTFLPVAGPIEKSAIKDPHDVELWLSVNGEMKQNDNTELMLFRIGRQLADISKVMVLEKGDIVLTGTPKGVGPVVTGDVLEAGMRIGGREVEEAKIKVEVKDRGGKYTFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCA0</accession>
    <name>F9XCA0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_72131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852630.1">
        <property type="nucleotide sequence ID" value="XM_003852582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCA0"/>
    <dbReference type="FunCoup" id="F9XCA0">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XCA0"/>
    <dbReference type="GeneID" id="13393971"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72131"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="InParanoid" id="F9XCA0"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="612"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="834" mass="93598" checksum="C53EBC30BCB68DC2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCM6</accession>
    <name>F9XCM6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852227.1">
        <property type="nucleotide sequence ID" value="XM_003852179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCM6"/>
    <dbReference type="GeneID" id="13396912"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93286"/>
    <dbReference type="HOGENOM" id="CLU_460201_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCM6"/>
    <dbReference type="OrthoDB" id="3799483at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP87203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="593" mass="65448" checksum="7E928D34555C3C81" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCT6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851391.1">
        <property type="nucleotide sequence ID" value="XM_003851343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCT6"/>
    <dbReference type="STRING" id="336722.F9XCT6"/>
    <dbReference type="GeneID" id="13401374"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_109761"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.155"/>
    <dbReference type="eggNOG" id="ENOG502R9SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593410_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCT6"/>
    <dbReference type="OMA" id="DSHMANK"/>
    <dbReference type="OrthoDB" id="3650983at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="130"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD02</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGP86881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104787"/>
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    </dbReference>
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        <location>
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            <end position="31"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="116" mass="12336" checksum="4ACC60AB0E5B36E5" modified="2011-10-19" version="1" fragment="single">MAPNARQPTADPFDRRSHLPMAKEIPITGPSTQRSIIFDPIQEICSGREIHMNTSYHCIYVPPPAPSAVNPSTSTSSSTSISKTSSTGPPRSALPPSPCQNALTRAAKSEALLHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDF5</accession>
    <name>F9XDF5_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
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    </protein>
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        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
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                <person name="Kilian A."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="de Vries R.P."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDF5"/>
    <dbReference type="FunCoup" id="F9XDF5">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDF5"/>
    <dbReference type="GeneID" id="13402200"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73150"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.369"/>
    <dbReference type="eggNOG" id="KOG2250">
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    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDF5"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="705"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP86487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120141" checksum="4FE7CA704B265B8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDQ5</accession>
    <name>F9XDQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_73304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851786.1">
        <property type="nucleotide sequence ID" value="XM_003851738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDQ5"/>
    <dbReference type="STRING" id="336722.F9XDQ5"/>
    <dbReference type="GeneID" id="13401696"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73304"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.480"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030461_1_1_1"/>
    <dbReference type="InParanoid" id="F9XDQ5"/>
    <dbReference type="OMA" id="PARGWFD"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36116" checksum="C81F4A603D72C75A" modified="2011-10-19" version="1">MATITASWTKLSTASQLQRSSHSVSAVNSTLHIFGGELKPREPRDNDLHIVSLAHGQDVSISSLPGSDTTPTARVGTASTVIDDKIYLFSGRGGPAMAPVDESGSLWIFDTKSQSWSNVKPKSSAYPEARSYHAMTSDGTKVYLHAGCPESGRRNDFWSFDVASSEWKELPSAPGPARGGTSIAFAEGKVWRMNGFDGEKEVGGSLDFYDPQTGKWETKTFSADGKSGPGARSVGALVPVKVQGQTWLVTLFGERDPSSEGHLGAGKMLGDVWAYDLEGGKWAQVLAMSTSGEAPDARGWFDADVVEFGGKDAVAVTGGLGEENNRLDDLWVLTFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEV7</accession>
    <name>F9XEV7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_44748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850865.1">
        <property type="nucleotide sequence ID" value="XM_003850817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEV7"/>
    <dbReference type="GeneID" id="13397733"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44748"/>
    <dbReference type="eggNOG" id="ENOG502RQHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_12_6_1"/>
    <dbReference type="InParanoid" id="F9XEV7"/>
    <dbReference type="OMA" id="WEAFENG"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8066" checksum="67E4953D47D3F36E" modified="2011-10-19" version="1" fragment="single">WPPYSPDINPIKHKVYELAPHIDNIINKDRQKEVLANVLPRAWKLISRDIIEEVISSMPRRVKALIAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF63</accession>
    <name>F9XF63_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_74298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850971.1">
        <property type="nucleotide sequence ID" value="XM_003850923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF63"/>
    <dbReference type="GeneID" id="13397633"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74298"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.761"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_5_0_1"/>
    <dbReference type="InParanoid" id="F9XF63"/>
    <dbReference type="OMA" id="DYDNIAP"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391608" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="92"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP85947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="408" mass="43959" checksum="C19790C2438B31C2" modified="2011-10-19" version="1">MKSLTLLSLLGTTAQAFPWVQNVPGVDNSMLSSLNRRQQNPAPGPGSAQTCPFNPNHVNAPEVTDQFPYNNARKGGRGNEKGGYLVPAPFDNVHRYIPPTARDIRGPCPGLNVAANHGFLARDGITTFAELVNAQQNIYNVGYDLSLLLAFLGLQADGDLVTTKLSIGCDATTRTSIAPLLTGSQPGLAGHNKFEGDTSLTRNDFFTGGGDNFSFNRTLFDMMSSTTGGNFNRENLAVYRKQRYDQSVAENANFFFGPLALLLFGAASFLYELMPSGSRNYAPDQETMNSFFIDERLPSNWINRVEPYSNGDVVREILAMYLEAPVLFGGNTAQGKFLGLDFGAIKEGKLDAGIEGPALTCLLYQLALGNVPSTLNGVVTPVVETLSGVFSVVSKEFANLGCARPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF77</accession>
    <name>F9XF77_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850902.1">
        <property type="nucleotide sequence ID" value="XM_003850854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF77"/>
    <dbReference type="GeneID" id="13397640"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94804"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.778"/>
    <dbReference type="HOGENOM" id="CLU_826934_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF77"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="299" mass="34208" checksum="0F91C0FA6D0A3920" modified="2011-10-19" version="1">MDGMRDLTFDNLELLLDLPVELKIMVAENFLFDIHLKVNAVRPRQGDRLITHHVVWVNEEEWAPFRVFAGMSPQTSSIAWKAFRDARTAGRIRIILDMEKHTINPSHWIPRSTATRPVPMRFFDEFTRLEATTPITMGTEHDEDERGFEVVVQRVSVVYDISPPIAPPQPGDNDRIISIRNEVLMDTSTTMNAPLFAAANEAITYGIHHPIPSPTIPTPYLTPLTPKGLWSLGNLLTHRARKIARHYQSEVHGTSRVWVENHVNSLNWISRVEKMKAEKAKADEEKAEEADDEYTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFG3</accession>
    <name>F9XFG3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850957.1">
        <property type="nucleotide sequence ID" value="XM_003850909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFG3"/>
    <dbReference type="GeneID" id="13397697"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94836"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.814"/>
    <dbReference type="HOGENOM" id="CLU_2199083_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFG3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="108" mass="11781" checksum="0B52871F8C368C39" modified="2011-10-19" version="1">MVTSNSSNHPTTMPPTNCTLLEIAPELRLRIYEYTFGPGPLKPGLGLLRTCSVINNEAKPIFGHCARLRVKTVMAEAKRCLGVMDSIIDGTYDPEKPYVAGGEEDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFI3</accession>
    <name>F9XFI3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_100850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850935.1">
        <property type="nucleotide sequence ID" value="XM_003850887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFI3"/>
    <dbReference type="STRING" id="336722.F9XFI3"/>
    <dbReference type="GeneID" id="13397673"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_100850"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="F9XFI3"/>
    <dbReference type="OMA" id="YQNWHAS"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="513"/>
            <end position="514"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="559"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="578" mass="63090" checksum="9AEAA1AE422577E2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9XG61</accession>
    <name>F9XG61_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_73604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850555.1">
        <property type="nucleotide sequence ID" value="XM_003850507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XG61"/>
    <dbReference type="STRING" id="336722.F9XG61"/>
    <dbReference type="GeneID" id="13401226"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73604"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.2"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_0_1"/>
    <dbReference type="InParanoid" id="F9XG61"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="493"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="640" mass="71113" checksum="BBC8422CEAA3241F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGT2</accession>
    <name>F9XGT2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850841.1">
        <property type="nucleotide sequence ID" value="XM_003850793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGT2"/>
    <dbReference type="GeneID" id="13397579"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94705"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.645"/>
    <dbReference type="HOGENOM" id="CLU_526994_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGT2"/>
    <dbReference type="OrthoDB" id="10401740at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="517" mass="58135" checksum="F286E121CFBB6360" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_95014</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGW5"/>
    <dbReference type="STRING" id="336722.F9XGW5"/>
    <dbReference type="GeneID" id="13402745"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95014"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.188"/>
    <dbReference type="eggNOG" id="ENOG502SBQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126161_0_0_1"/>
    <dbReference type="InParanoid" id="F9XGW5"/>
    <dbReference type="OMA" id="SEMIMAH"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19775" checksum="1685B8826E03A296" modified="2011-10-19" version="1">MSSQELPQPAADRQKYLKDENNQDSAAPTGNDNQKEEGQMLPPPLPPSSSALPSSDPAPTPASDEAEIPSSPSKPSSSETKLKPPNPALLAAQASLSTLQAERQSLVNSMPLPAGLQMPDEWSDEKKSEEAFKSANAIIKNHIDLLHRYNEIKDVGMGLAGLVAEKRGVRVKVLMEEVGLDEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH45</accession>
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        <recommendedName>
            <fullName evidence="2">Glycosyltransferase subfamily 4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MYCGRDRAFT_101096</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003850127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH45"/>
    <dbReference type="STRING" id="336722.F9XH45"/>
    <dbReference type="GeneID" id="13394584"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101096"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_23_0_1"/>
    <dbReference type="InParanoid" id="F9XH45"/>
    <dbReference type="OMA" id="HTNFPQY"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="476" mass="51566" checksum="79B98AEC0AA2B11F" modified="2011-10-19" version="1">MSTTTAPVVPWHADFPRELVGKKILLATESLGPVNGVSRTTQSLVDYLRSNGVNVATCAPTYKGQPIVASSTPSSTSKFRLQGFPLPYNPDLSIAYPFRLGRIYQQTFGDSAPDLIYLASPASVGFQFLIQLRSLPSGTCPPICLNFQTDLAAYASIILSPPLDAYGVWLLQKVQGYLFSAPAIRTIFYPSAYVAKYMSSAGAPAEKMLQLGRGVDTTLFNPDKFDRTYRRTIAGNDEIIFVCISRLAPEKGFEFLASAATRLLTTAPDLKWKLLIVGGNTSPSVDASIRSLFSSPELAPRVHFTGMLRGASLARAYAVADVFLHCSITETFGLVVLESMASGVPVIARDEGGPSETVKHGDSGYLVDPLDMETFVARAQELAVNINRRKSMALAARRQAEGLTWNAINCKVAHKLVEALRSAGRLSSPDNDDEKAAYGGWWGLVKVYCAVGIVWVFWCIAVLPLIAAGLVHGMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI19</accession>
    <name>F9XI19_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_27172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849887.1">
        <property type="nucleotide sequence ID" value="XM_003849839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI19"/>
    <dbReference type="STRING" id="336722.F9XI19"/>
    <dbReference type="GeneID" id="13395182"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_27172"/>
    <dbReference type="eggNOG" id="ENOG502S5J2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1566718_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI19"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395526" description="MARVEL domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18746" checksum="0B10742F92947230" modified="2011-10-19" version="1" fragment="single">KAIIHGVQTLLVFIAGCLTLAVMAKSYGHGGETKYYFALCFFTLPAVAFQVVVPLWSRAWRFCNVYAFATIDLLFCILWFAAAIAVAVWNASEVTTKEKPKNEATPKRDDTKETNPTKVLACGSENICKVSKATVGFAVVLFFLFAAASYLSICALIEYRKTGVKPHSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XI91</accession>
    <name>F9XI91_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_95253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850080.1">
        <property type="nucleotide sequence ID" value="XM_003850032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XI91"/>
    <dbReference type="GeneID" id="13394281"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95253"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.476"/>
    <dbReference type="HOGENOM" id="CLU_385045_0_0_1"/>
    <dbReference type="InParanoid" id="F9XI91"/>
    <dbReference type="OrthoDB" id="3646226at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="718" mass="82458" checksum="4DC8198311BFF476" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XID5</accession>
    <name>F9XID5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_87039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850498.1">
        <property type="nucleotide sequence ID" value="XM_003850450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XID5"/>
    <dbReference type="GeneID" id="13402712"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87039"/>
    <dbReference type="eggNOG" id="ENOG502S179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="InParanoid" id="F9XID5"/>
    <dbReference type="OMA" id="NIPNANW"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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            <end position="61"/>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="230"/>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28499" checksum="DC65893A083BBBAD" modified="2011-10-19" version="1">MHHPDPPQDLRIPRSTLEKIYLNPPTDVKGEFRNTFANPTPLGLVGFLVATVPMSLSLMGLHGGNGGGGGQATVAFGLFFGGVLQLLSCLMEWILGNTFSFLVFGSFGAAWTALSCSNLPAFDAMGSYLTGANTPEEIARGKAAFSADFAFGLATFALLVLTFALCSLRTNLVFFITFLLATAAISLLAGSYWALALEAAHTAAEMQRATGVILFTCCVLAWYLLVANLLEVLEFGWELPVGDLSGRFGGGKREGKREWRDRSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Speckled leaf blotch fungus</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="594" mass="66112" checksum="A8E56C33404AC850" modified="2011-10-19" version="1"> </sequence>
</entry>
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    <accession>F9XIR6</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="16754" checksum="A13FF990C47B1A8F" modified="2011-10-19" version="1">MQWCFVLALRRCCFRESKNQYDIFFRTSRNYQESLASTPQTVEREHHARPPGEAMTASTEHSGAWKTYIANRAGSRKGSRPTTSRPKVYFPPRMNLEESLWHEEKSSDEPRCVADAASWVEYRQAKFGVIASKAAEDTNNARTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ12</accession>
    <name>F9XJ12_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849826.1">
        <property type="nucleotide sequence ID" value="XM_003849778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ12"/>
    <dbReference type="STRING" id="336722.F9XJ12"/>
    <dbReference type="GeneID" id="13402623"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95543"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.84"/>
    <dbReference type="eggNOG" id="KOG3730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ12"/>
    <dbReference type="OMA" id="ENMICKM"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="818" mass="91566" checksum="A992AFA0A435E0BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJH6</accession>
    <name>F9XJH6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_47119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849768.1">
        <property type="nucleotide sequence ID" value="XM_003849720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJH6"/>
    <dbReference type="GeneID" id="13399045"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47119"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.201"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJH6"/>
    <dbReference type="OMA" id="WESHSTP"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391703" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="470" mass="51288" checksum="67E962A17183477C" modified="2011-10-19" version="1">MKYLLFSALQCLLLPAALAQCSDQGETFQRDVVILGGGSSGLYSAVRLQQMGKSVAVVEKQGRPGGNTNTYKDEATGKTFDYGVKVLVNTSLVYNFFTSLEIPLAPLGAVSPATKTVAADFAHGELGPQWPVVNANDSLAALERYKVQLAKYSPEFFRGYHLPDPVPEDLLIPWGEFLAKYDLGPLAYDGFGQFQGMGNILAQPTLYMMKLFNPMQVEAREKKTKVSEANGNTQALWDSAQRYLGEESLILNSKVTSIKRHNDGVEVVVSTPTGTKTIHASILIITVQPKLDLLSPFLDLTDEENQLFGQFNNSYYSNAVIANTGLPENTTIINYDQHATYGLPPLPGIYSVDYQPIQGLRSVQHSSPSPVTDEEIKADILDSVGRVRKALSLPNPEEETEIICFNNHSPSGLAVSVDAIKAGFFKRYVALQGQTRTFWTGQAWTSGSSSTIWDFTEVEVLPAVISALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJZ0</accession>
    <name>F9XJZ0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_75499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849377.1">
        <property type="nucleotide sequence ID" value="XM_003849329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJZ0"/>
    <dbReference type="GeneID" id="13402532"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75499"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.264"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="F9XJZ0"/>
    <dbReference type="OMA" id="SIPGYMM"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="322" mass="34135" checksum="A4993E399758A665" modified="2011-10-19" version="1">MATSPSNLEDGSSPTPAAKSALATVGRQLLPFVIGGGSGIVATTCVHPIDMVKVRLQLLGEGSSAKAASPLAVGRQIVAEGRFLDLYSGISAAWLRQASYATLRLGFFDRFQAVLVERAKAKDTTIGFGERALAGLGAGGLAAAIANPSEVALIRMQADGIKPKAERANYRSVVDALVRIGKTEGITALWSGSYPTIIRAMATNFGQLAFFSESKNQLTQRTSLSGRNVTIASSCVAGFFAAFFSLPFDFLKTRLQRGGSTYSGVLDCAVKVAKQEGLLRFYRGFGTYVLRIAPHSIITLIVADNVNAVVRQQLDGEVVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK14</accession>
    <name>F9XK14_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_62652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849618.1">
        <property type="nucleotide sequence ID" value="XM_003849570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK14"/>
    <dbReference type="FunCoup" id="F9XK14">
        <property type="interactions" value="1453"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK14"/>
    <dbReference type="GeneID" id="13402295"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_62652"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.501"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="InParanoid" id="F9XK14"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="861"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="917" mass="101872" checksum="6B64DC23C9F5553E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK17</accession>
    <name>F9XK17_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_47510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849501.1">
        <property type="nucleotide sequence ID" value="XM_003849453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK17"/>
    <dbReference type="FunCoup" id="F9XK17">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK17"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="13402413"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47510"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="InParanoid" id="F9XK17"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="25205" checksum="948AB78B7AF8C7B1" modified="2011-10-19" version="1" fragment="single">LENNPEVMTTLLHNLGLSPTLSFHDVYSISDPDLLSFVPRPAHALLLVFPVSSSYESHRRTEDASLPTYSGSGLLEDVIWYRQTIGNACGLIGLLHAVSNGAARGMVQPGSELEKFINAAVPLSPADRAALIENSDVLANAHASAAATGDTVPPEAGDDVDLHYVCFVKSEKSGKLWELDGRRKGPLDRGVLSEGEDVLSEKGLDVGVRAFLKREEEASGGGELRFSLITLAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK41</accession>
    <name>F9XK41_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_101300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849605.1">
        <property type="nucleotide sequence ID" value="XM_003849557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK41"/>
    <dbReference type="STRING" id="336722.F9XK41"/>
    <dbReference type="GeneID" id="13402309"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101300"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.531"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="InParanoid" id="F9XK41"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="248" mass="27309" checksum="A8B8F804DE6F33DC" modified="2011-10-19" version="1">MASGSAPATPLLYSCIAYNSTILAEHTTSAISGTSNLASIILPKISHDSAQKLTYTHNDNFIHYIADAAPSSASPDNLSGAGLTYLVVAKADLGRRIPFGYLVEIKKRFLSTFNPESTSFSSLPAYGAAAFNTQMRQLMVEYGTTKAGQDDAFKNVQNEIDNVRGIMTENIERVLERGERIDLLVDKTDRLGGSARDFRVRSRGLRRRMWWKNVKLMVLLTVVVIFLLYLLVGFGCGLPAWGRCIHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKM2</accession>
    <name>F9XKM2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CYP-55</name>
        <name evidence="15" type="ORF">MYCGRDRAFT_48936</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848839.1">
        <property type="nucleotide sequence ID" value="XM_003848791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKM2"/>
    <dbReference type="GeneID" id="13398628"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48936"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.214"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="F9XKM2"/>
    <dbReference type="OMA" id="NICGQMP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP83815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="555" mass="62825" checksum="0F08B76C7DE29F9C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKX5</accession>
    <name>F9XKX5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_110922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848754.1">
        <property type="nucleotide sequence ID" value="XM_003848706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKX5"/>
    <dbReference type="STRING" id="336722.F9XKX5"/>
    <dbReference type="GeneID" id="13398779"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110922"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.42"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694491_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKX5"/>
    <dbReference type="OMA" id="MTYATSA"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="404" mass="43117" checksum="2481300930C90BDF" modified="2011-10-19" version="1">MLQYAASNAPQTFSRRSSVFADPPSRSTDKALSSYDSHTGYNIPRPPSTLSQATTSSEQHRSKSFSSLTGSLDSSAALSQLAMLAAQAPAAEMNTNNGSSDSTRSGTPNNAMNGVNNAQYASAPHATAGGNQTGGGPPVCQNCSTSTTPLWRRDESGSVLCNACGLFLKLHARPRPISLKTDVIKSRNRVKTAQPKKRDSNGGADGLMQAPHSNSFGTSQNDIVHNGHQHSLPMSQSLEHSVRAPSPTSASRSNTPLNQHSSSAIAPQHIFDTVNLPSADSSFSASPSLPHFSLRNPSPAPSSLNGTANGHMEPPQTYDVLLHQNQILRTRVSELEVINDLFRGRVSELEGNGEVLRLKAELGAAHERAEQMQKRIMDLETELREGPARKKARLEHGSETNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XL35</accession>
    <name>F9XL35_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_105946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849128.1">
        <property type="nucleotide sequence ID" value="XM_003849080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XL35"/>
    <dbReference type="STRING" id="336722.F9XL35"/>
    <dbReference type="GeneID" id="13398042"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105946"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.277"/>
    <dbReference type="eggNOG" id="ENOG502SBW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_3_1_1"/>
    <dbReference type="InParanoid" id="F9XL35"/>
    <dbReference type="OMA" id="MYFNVTM"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7740" checksum="6B6335DDF6FB558B" modified="2011-10-19" version="1">MPRINVTLKKGADASQLEQAKKQVQEQGGKIVEEFTLVKAFTAEFPADTVHTLQTNDHVTVEDDGEVKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLB3</accession>
    <name>F9XLB3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_28547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849192.1">
        <property type="nucleotide sequence ID" value="XM_003849144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLB3"/>
    <dbReference type="STRING" id="336722.F9XLB3"/>
    <dbReference type="GeneID" id="13398739"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28547"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_5_1_1"/>
    <dbReference type="InParanoid" id="F9XLB3"/>
    <dbReference type="OMA" id="DIAFEPM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP84168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="160" mass="17700" checksum="7E513319D449638A" modified="2011-10-19" version="1" fragment="single">PAKRRSKLAKDNDISAEEEAEIQEAFTLFAKPDEDDPSSKDHLIATSDDNAELAELIETVDPDDAGWVGYEHFVAIAALKLRARDNDPDVVSEEVEKAYRLFTKGEDRAITLLDLKRVARELREEVPDNVLKDMIREATGGGLGGVGMEDFEGVMRRAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLG9</accession>
    <name>F9XLG9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_96290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Ben M'barek S."/>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
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                <person name="Conde-Ferraez L."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Hane J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
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            <end position="41"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="316" mass="32258" checksum="2DFC2DD42438A94D" modified="2011-10-19" version="1">MSNNPTLINLPPHPSDPVTPSEVPSRSGTPNSTTTSMSELSTVAIKDGHRGLGPHHHHQASGLSSQLDAERADRISRLAGLERVTTARNPQTPTSLNPGGQPGSFNSPANQPPHVQSYFDASGNPVLARERSTVGSASATGSVGARTTWAGSEAGDTSNFDKMSESQDLDMERDTSSIGGGDYMSEDGETGGLVAFGEGARTPARGSMMGLSSAIGSPSGKATATTPRGGGQGDVRMGDDGDTSSLGAGSFGAGGGGFGAMGAPPPQGHAAQQAERIVRENMNTTSQDRMTSHNETSPKRGGAGQEPQLGKFGFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMH9</accession>
    <name>F9XMH9_ZYMTI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848720.1">
        <property type="nucleotide sequence ID" value="XM_003848672.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XMH9"/>
    <dbReference type="GeneID" id="13396565"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96474"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.46"/>
    <dbReference type="eggNOG" id="ENOG502SWQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470265_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMH9"/>
    <dbReference type="OMA" id="WRLGHSK"/>
    <dbReference type="OrthoDB" id="5430717at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="580"/>
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    </feature>
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        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="327"/>
        </location>
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        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="580" mass="64580" checksum="9B1ADE75B274F036" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XML0</accession>
    <name>F9XML0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MYCGRDRAFT_76672</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003848660.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0739">
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    <dbReference type="OrthoDB" id="29072at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein retention in Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
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        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="435" mass="48047" checksum="BB18560397E667FD" modified="2011-10-19" version="1">MSNTDFLGRAIEAVKKAIEQDTAGDYDKAYQQYYQALELFMLALKWEKNPKSKDMIRQKAGEYMERAEKLKNHLAENDGKRKPAAMGSNGAVGSNGGGKGKEDEGEDQDPESKKLRGALAGAILTDKPNIKWEDVAGLEQAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSFLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNLARENKPSIIFIDEIDALCGPRGEGESEASRRIKTELLVQMDGVGRDSKGVLILGATNIPWQLDAAIRRRFQRRVHISLPDQPARMRMFELAVGDTPCEMSADDYRTLARLSEGYSGSDITIAVQDALMQPVRKIQTATHYKKVDVDGVEKLTPCSPGDAGALEMDWTQIETDQLLEPRLMVKDFVKAIKSARASVSSEDLVRSAEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN44</accession>
    <name>F9XN44_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_25825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848601.1">
        <property type="nucleotide sequence ID" value="XM_003848553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN44"/>
    <dbReference type="FunCoup" id="F9XN44">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XN44"/>
    <dbReference type="GeneID" id="13396274"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25825"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029204_0_1_1"/>
    <dbReference type="InParanoid" id="F9XN44"/>
    <dbReference type="OMA" id="MPSVMPW"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="300" mass="33048" checksum="5AB05B9B4BB841AA" modified="2011-10-19" version="1" fragment="single">STFQPLMSTFSYFADPVRYTVSGLVRRISIDDAPTPLAKALSANYNGSMHDPTSGYYNPPKRRLSPFQPPPLTPLSLSGYRDNTPHKARLLRRSVAEEIRLLLPPRLQLQDTWHLTYSLEQDGSTLSTLYSLCDQHRGKRGGFVVVVRDGTGGVFGAYLSDAPRPQSAYYGSGECFLWRAFVLPALPDLMDLPPPPSADTTHAQRMTTIAVGTPRNGRHRNGGLAVPSEGIRFKAFPYTGENDFSIFCQQEYLSVGGGDGHYGLWLDRELRKGVSETCPTFGNEGLSEEGGKFEVLGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNB6</accession>
    <name>F9XNB6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848411.1">
        <property type="nucleotide sequence ID" value="XM_003848363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNB6"/>
    <dbReference type="GeneID" id="13396423"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106176"/>
    <dbReference type="HOGENOM" id="CLU_1639540_0_0_1"/>
    <dbReference type="InParanoid" id="F9XNB6"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="18962" checksum="744F76D27102C178" modified="2011-10-19" version="1" fragment="single">NNIQQPTTNNIQQPTTLPNNIHSTHHHNALHSKPHPRGPPHHLRPRLSPCPERRRYGRHHRTPQQLRRLHIRPRDRQRRQRPIQVGLPAAPRRLHRQTEQVLAHLRPSHHWYRSHLPILRDGGCLRYVRLDRTGRHYGSNEGLVELVEGWRNDAGSGRDAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNH0</accession>
    <name>F9XNH0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_111431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
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                <person name="Bristow J."/>
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                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="van de Geest H.C."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
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                <person name="Lombard V."/>
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                <person name="Martins N."/>
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                <person name="Rudd J.J."/>
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                <person name="Shapiro H."/>
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                <person name="Ware S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
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                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
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                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </alternativeName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
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                <person name="Ponomarenko A."/>
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                <person name="Stergiopoulos I."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
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    </comment>
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        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S acidic ribosomal protein P1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_P1/P2"/>
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        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="110" mass="10940" checksum="D1C81396320DF3C0" modified="2011-10-19" version="1">MSTSELASSYAALILADDGVEITADKLQSLISAAKVADVEPIWTSLFAKALEGKDVKELLLNVGSGGGAAPAAGGAAPAAAGGAAEAAPEAAKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNZ0</accession>
    <name>F9XNZ0_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MYCGRDRAFT_101786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848109.1">
        <property type="nucleotide sequence ID" value="XM_003848061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNZ0"/>
    <dbReference type="FunCoup" id="F9XNZ0">
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    </dbReference>
    <dbReference type="STRING" id="336722.F9XNZ0"/>
    <dbReference type="GeneID" id="13401607"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101786"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.297"/>
    <dbReference type="eggNOG" id="KOG1112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="InParanoid" id="F9XNZ0"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051063">
        <property type="term" value="F:CDP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046704">
        <property type="term" value="P:CDP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006240">
        <property type="term" value="P:dCDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="802"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGP83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="916" mass="102041" checksum="427AB69D15A87853" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP40</accession>
    <name>F9XP40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_106396</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848006.1">
        <property type="nucleotide sequence ID" value="XM_003847958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP40"/>
    <dbReference type="FunCoup" id="F9XP40">
        <property type="interactions" value="1285"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XP40"/>
    <dbReference type="GeneID" id="13402126"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106396"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="InParanoid" id="F9XP40"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="384" mass="42041" checksum="246D7699FF875CED" modified="2011-10-19" version="1">MSNQAPHPALLIPGPIEFDDAVLQSMSHYSESHVGAPFVKTFGEALSMLRQLFQTTNPASQPFVISGSGTLGWDQVAANMTEPGDEALVLHTGYFADSFADCFETYGVKVTQLKAPIGDRPQLDDIEKALKERKYKVLTVTHVDTSTGVLSEIPALSELVRRVSPETLLVVDGVCSVGCEEIRFDEWDIDCVLTASQKAIGCPAGLSILMVSGRAIESFKARKVRPNSYFGSWKNWLPIMQNYEAKKPSYFATPSPQLVHALHTSLTQILSRPLAERFARHKEVSDKVKKAITDLGLKQLASKPENQASAMTAIYLPNDLTPPEVLPSLLKKGVIFAGGLHKEIAAKYIRFGHMGVSIMDPQRTDIDDAIKALKEGLEEAGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XP96</accession>
    <name>F9XP96_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF654-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_50458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848058.1">
        <property type="nucleotide sequence ID" value="XM_003848010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XP96"/>
    <dbReference type="STRING" id="336722.F9XP96"/>
    <dbReference type="GeneID" id="13402105"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50458"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.422"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="F9XP96"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="74983" checksum="A699895C272C22AD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPT2</accession>
    <name>F9XPT2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MGSUL5</name>
        <name evidence="9" type="synonym">MET3</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_111611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EGP82517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003847493.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111611"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="reaction ID" value="UER00204"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
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        <property type="term" value="P:cysteine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
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        <property type="term" value="P:methionine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfate adenylyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
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        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="112"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="282"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="503"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="503"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="542"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
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        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
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    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP82517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="683" mass="75929" checksum="8D59852C44569369" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPT6</accession>
    <name>F9XPT6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_17609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847545.1">
        <property type="nucleotide sequence ID" value="XM_003847497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPT6"/>
    <dbReference type="GeneID" id="13400830"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17609"/>
    <dbReference type="eggNOG" id="ENOG502S6CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058267_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPT6"/>
    <dbReference type="OMA" id="MLRCYNS"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21455" checksum="13FA3D84B995C915" modified="2011-10-19" version="1" fragment="single">TEGKDEYNYYSGTYEDGGWPKKQDWISFENMWNNNMDKMKSSCGAHHFGDNLSDVEIEHIQTAIQRVAKTSKVDNRFIFALIMQESKGCVRVHNTNNGVRNPGIMQSHNGHEYDPEHSEKSIEQMVVDGTQGTSSGEGLVQGLDKTGNAYAAARFYNSGQIAKDGDLSDGAGATACYASDVANRLTGWVDAKSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQL3</accession>
    <name>F9XQL3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847494.1">
        <property type="nucleotide sequence ID" value="XM_003847446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQL3"/>
    <dbReference type="GeneID" id="13400605"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97556"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.35"/>
    <dbReference type="HOGENOM" id="CLU_1972203_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQL3"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="127" mass="13546" checksum="99C5553723BEE4B9" modified="2011-10-19" version="1">MATTRFISAIISRFVCICTTFTSNYTNNATLVLVWHPNALPSAMIGRSGTVLVEISRVIGPACVERGPGTAQIRRDCRIADPILSVTEQSDLDLQLGISLPQCISYAASGIAMLSTFTVAIESLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQM5</accession>
    <name>F9XQM5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847486.1">
        <property type="nucleotide sequence ID" value="XM_003847438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQM5"/>
    <dbReference type="STRING" id="336722.F9XQM5"/>
    <dbReference type="GeneID" id="13400597"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97566"/>
    <dbReference type="eggNOG" id="ENOG502S6BE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664241_0_0_1"/>
    <dbReference type="InParanoid" id="F9XQM5"/>
    <dbReference type="OMA" id="SEAHIWR"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="445" mass="50121" checksum="292BF5DE0DE2573D" modified="2011-10-19" version="1">MIRSLVAPTQVVQPTLQKRDEERLGKIGVKNQELYEAYLEYRTKARAQEKQIEQMVTFNEFQAQENKILESTNLRLREQVMQHSYAAKQIRDAADEAVAAAKQKVTAVQDKGESVAKSCRDYEKQIERLESTIRNMQAAQLHAVESTQWAPLPTFEIEHRLKLLHSGVRQWAESNSGLTLEQVLDPERFKSTMQALMLRGCIQPDARLRECLLRNRAMLKPGKASQVLLTAAVSFDILSKIIGDPFFAFVGGMDDCVLRKCHGADIEILLGLIRNSDEAGAEALRCQLLRLLDPPTAEADSSVAFVKDLVKESRHRAMVEVVNSAIDEFMGPLSNEQYEHAYNGLAALVHDACELSWALWTRKARVEVHNWSSIKHQTNSMSYKSTSDVFEVHPLHKRDLEHTPEALDGHSITLLCTPLVLVAGNAEGEQYENKAVLKKAIVWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQR4</accession>
    <name>F9XQR4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CrcB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_101931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847426.1">
        <property type="nucleotide sequence ID" value="XM_003847378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQR4"/>
    <dbReference type="FunCoup" id="F9XQR4">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQR4"/>
    <dbReference type="GeneID" id="13400563"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_101931"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.79"/>
    <dbReference type="eggNOG" id="ENOG502QT5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030507_1_1_1"/>
    <dbReference type="InParanoid" id="F9XQR4"/>
    <dbReference type="OMA" id="CYDLQHV"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47014" checksum="EC7C15B2578CC46A" modified="2011-10-19" version="1">MPDHESELAREESGLDELAAPAPDENPNEQGFYQHESLESHRRQTKEQIETEQEQQPAPSRTSQWLTQLYIFSYLIFFSIFGVLARTGLQALTVYPGALIANTDLWANIGGSFTMGMLREDRMLFRRHWKQEMEKARREASSSSDDPVAEKNDKDLEDTARKSFTSTKGGIPAYVGLTVGFCGSFTSFASICRDAFLAISNNLNTAVVSTQDTISLPRARPTGDSVMAVLALLILEVGLSTVALTCGAHLGAALARPAEHIPALKLSRIMNPLVVFLGFGCWLGAILLTIWPIRDAWRGQVLFSLVFAPLGCLLRFQLSVRMNKLVRSFPLGTFAANVFGTCVLGMAYDLQMSSAASSIVSCQVLQGIMDGFCGALTTVSTWVLELDTLRLRHAYFYGACSLFIGVGFITAIMGSLRWTTGFTAPTCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR40</accession>
    <name>F9XR40_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847304.1">
        <property type="nucleotide sequence ID" value="XM_003847256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR40"/>
    <dbReference type="STRING" id="336722.F9XR40"/>
    <dbReference type="GeneID" id="13400108"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97702"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.5"/>
    <dbReference type="HOGENOM" id="CLU_066466_1_0_1"/>
    <dbReference type="InParanoid" id="F9XR40"/>
    <dbReference type="OMA" id="EWYPEFS"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23489" checksum="26BC299E3AAD14A7" modified="2011-10-19" version="1">MEVGTWNVRTSSENCLPWARDIQYVSYPDWAGAIQYGEEITEVSASFIVPEASKPKHAEEGIAWEVQDNDKTVYSAWSEWWPTGSIDYDDFTLKPGDVIFVRVVANGKTGGTTYIQNEATGQTASKTFTNEPSLCLTSAEWIVEDDSGFGPKPFAKFTPVEFIAAEYTQHKKSVSGIKGATMVDMVQDGYDVADCSIDGDDGLTCRYTGYGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRD5</accession>
    <name>F9XRD5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_97787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847212.1">
        <property type="nucleotide sequence ID" value="XM_003847164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRD5"/>
    <dbReference type="GeneID" id="13399646"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97787"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_17.14"/>
    <dbReference type="HOGENOM" id="CLU_750510_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRD5"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="369" mass="40595" checksum="96799FC507E805CF" modified="2011-10-19" version="1">MIHLAKSGGEDTTPRTSGTYPSATNSIAASDENAETGVDQSGSTKGAGSEPHHHHHHHHHRQSRSGLVTFHDWIQSEHFSHLSRRRPLDEKVILSTPQGWEALHGVLASSSDSGDHDGHGRDGQDPRPARGSSGSGSLGRSGRIDKVRRLARLMRNTLALNVLGVILLVGIFSYRNRIAVFVDQRHGVLTIRGSKHAVHDGHMFGRPVFAFSAPPPTVVRGSILSEVVPSYNGSAAMGTVELALHLHAMRIVHHAFLLEKEEDVMMMMTSHHLTSPEGLSLLDQQYRELLEMDTIIALLLKTGLSSRSWCEVEVERTRARLLRMSGRFRFRAGGADDDDDDGVGRGMIEGVNLFAEECFRSVSAWEVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRK0</accession>
    <name>F9XRK0_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847172.1">
        <property type="nucleotide sequence ID" value="XM_003847124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRK0"/>
    <dbReference type="GeneID" id="13399680"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97846"/>
    <dbReference type="HOGENOM" id="CLU_1035152_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRK0"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="269" mass="29915" checksum="AC8D461642B1C0B9" modified="2011-10-19" version="1">MPDRNRKRDQDGDDSDTIMDVDHVFSLFRRDSDHWQHQRSRRPPIVDVRRRCRTFTAPSVPTLPVSLAQLHPANKLRITEGTVAPVFEPAAQINNDQIQQAVKSHKERSQARRAEREHAIRAERKKNLARIAKRKTECERKYEENRSREAAGNSDSQAAQFEGNADGFGSDSDNDSESDSDGDGDVAPNDAGPNDLDADTESIQTSRSNGVARHTVPEKRRQSSSVSPSMYSNKRQRRGSDADPTLLSGQVPNPGNHTPSLSIVGDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS41</accession>
    <name>F9XS41_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_98030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846926.1">
        <property type="nucleotide sequence ID" value="XM_003846878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS41"/>
    <dbReference type="GeneID" id="13396713"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98030"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_20.43"/>
    <dbReference type="HOGENOM" id="CLU_1908338_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS41"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP81902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="133" mass="14329" checksum="6710337F3B49E5FA" modified="2011-10-19" version="1">MYYPSPVLHCSGPPQRPGQQAITAVSLLSKARNEDLQCMLDLDGAHAGVAGMLSAGLLASLTLSYKQVGLGCRRKPQGHERPYFGLLASISIAVFPSLTSIHRFCQRLIKIAYEESVEGLKSDTPSLKAVCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS87</accession>
    <name>F9XS87_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_98076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846906.1">
        <property type="nucleotide sequence ID" value="XM_003846858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS87"/>
    <dbReference type="GeneID" id="13396680"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98076"/>
    <dbReference type="HOGENOM" id="CLU_1062489_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS87"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="262" mass="29226" checksum="0AD0A0FDFFFF7D0D" modified="2011-10-19" version="1">MQNFSMTGIEIPYVVACHAYRGYHADLMQAMLDGGLSATHITVEDVGRFLGVLEGTFNTDKPERGSNQTEPREEPEDSNQHAGLFFAVPTGIVVRNAKGRLIRGLHGSDSTLPRQALHRFGRLYEMWATGYQKALADFSCYSKMVDVHPGSDFIGSRGTKKVPAGLTRPVPAEGDTAFLLYTYLLSRLPEGGKVLCSKEALEKFGKSGTEASYHGFLEYVKDPQFASHPGQQHWVKALDKKCAVFMYLAKTIPLFRDCKWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSD9</accession>
    <name>F9XSD9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar import/degradation Vid27 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003846871.1">
        <property type="nucleotide sequence ID" value="XM_003846823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSD9"/>
    <dbReference type="GeneID" id="13396662"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98129"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_21.71"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700590_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSD9"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="394" mass="43257" checksum="4EDBFB56412E99FF" modified="2011-10-19" version="1">MTTEVALFDYEATSTLLDHALVSAWHWAEPKRFSKGAEKLLFPRRTSNISARESKRRKSSSRLFLDLGHLIISVLQIAEVTRHVYYTFHSVCLVHIRSGGVTMVVPQGFSAEQIGKTSTSTNPAHRNCFRHTTLPSHKPMITPTRTSGGKLASSDATSDLSSLDHNTAANRRCDQAATSTSTPASMANGKITIGSPVHDSAAMSNCLTNKGRSRDNLVHCRLFDRLGINAKTALLALLGDPVLGVDVSTDCRWLLAACKTYLLLTDTLQSEGKNVGKLGFEGHSPNAISRNRVGSPLRLPTWRSSSIKPRHLIKKLKKGLTQTLPRKSRIKTPATNVKLTKPQDTLRKTSPNYIKATPTSKTSAERPQRSPKGYGELIFTDAAGFICRINQDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5H2</accession>
    <name>A9Y5H2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">NADH-ubiquinone oxidoreductase chain 5</fullName>
            <ecNumber evidence="3 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">nad5</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="22"/>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 17"/>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648743.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5H2"/>
    <dbReference type="STRING" id="336722.A9Y5H2"/>
    <dbReference type="GeneID" id="5846271"/>
    <dbReference type="InParanoid" id="A9Y5H2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010934">
        <property type="entry name" value="NADH_DH_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005141">
        <property type="entry name" value="PRK06590.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06455">
        <property type="entry name" value="NADH5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01435">
        <property type="entry name" value="NPOXDRDTASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 17 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <keyword evidence="13 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002747240" description="NADH-ubiquinone oxidoreductase chain 5" evidence="18">
        <location>
            <begin position="18"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="20">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="19">
        <location>
            <begin position="130"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="NADH dehydrogenase subunit 5 C-terminal" evidence="21">
        <location>
            <begin position="503"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABU40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="900" mass="101550" checksum="CF50A8503434205E" modified="2008-02-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WW91</accession>
    <name>F9WW91_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_102189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856075.1">
        <property type="nucleotide sequence ID" value="XM_003856027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WW91"/>
    <dbReference type="FunCoup" id="F9WW91">
        <property type="interactions" value="702"/>
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    <dbReference type="STRING" id="336722.F9WW91"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102189"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_4_1_1"/>
    <dbReference type="InParanoid" id="F9WW91"/>
    <dbReference type="OMA" id="TFIVHRE"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP91051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="370" mass="40739" checksum="01D201EEC56A43EC" modified="2011-10-19" version="1" fragment="single">MLYNYNGEDYLLHLVDTPGHVDFRAEVSRSYASCGGAILLVDASQGVQAQTVSNFYLAFAQNLALVPVLNKVDLPSADTGRTLEQLRDTFEIDSSNAVMVSAKTGLNVAKLLPTIIEGIPAPTGDENAPLKLLLVDSWYDNYKGVILLVRIFEGKVRAGDRIVSFATGLEYIVGEVGIMYPLETPFNKVLRAGQVGYIFFNPGMKRSKEAKVGDTYTTVGDQHKVEPLPGFVEPQSMVFVAAFPTDQSDYAHLEDSINQVLLNDRSVTITKESSEALGAGWRLGFLGTLHCSVFEDRLRQEHGASIIITPPSVPFKLVRKDGSEEIIRNPNLFPEGRDLHTHAMTLEEPYITATITLPEEYLGKVIELCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWE4</accession>
    <name>F9WWE4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_98423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856209.1">
        <property type="nucleotide sequence ID" value="XM_003856161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWE4"/>
    <dbReference type="FunCoup" id="F9WWE4">
        <property type="interactions" value="853"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WWE4"/>
    <dbReference type="GeneID" id="13403010"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98423"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="InParanoid" id="F9WWE4"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP91185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="365" mass="40844" checksum="F732C53CD10DC6A4" modified="2011-10-19" version="1">MEDASQPPVAVVCVGMAGSGKTTFMQRINAHLHEQSTEAPPYVVNLDPAVRSVPFDSNIDIRDSVNYKEVMKQYNLGPNGAILTSLNLFSTKIDQVMDILEKRCLPQPNSQNKALPGHIIVDTPGQIEVFVWSASGNILLSSLASSFPTVLAYIIDTPRTTENTSTFMSNMLYAISILYKTKLPMILVFNKTDVKSEEEAVDWMRDFEKFQEAVHAEEEHQREGGGYMGPLLNSMSLVLEEFYNQLSVVGVSSMTGDGVDDFFAAVEEKRVEFEKDYKPELIRRRAEAEEQKSQIREQEVNRMMKDMNDDDDDDEGLVDPDVEDEAEIDQAFEEGLKARYEAALRDGSAAAGPNSAAEYIRNSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWM8</accession>
    <name>F9WWM8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_53277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857302.1">
        <property type="nucleotide sequence ID" value="XM_003857254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWM8"/>
    <dbReference type="GeneID" id="13394929"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53277"/>
    <dbReference type="eggNOG" id="ENOG502SJC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_1_1"/>
    <dbReference type="InParanoid" id="F9WWM8"/>
    <dbReference type="OMA" id="WPNVWDA"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="522" mass="58440" checksum="486CF604A5E7495D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWN6</accession>
    <name>F9WWN6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_102532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856375.1">
        <property type="nucleotide sequence ID" value="XM_003856327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWN6"/>
    <dbReference type="STRING" id="336722.F9WWN6"/>
    <dbReference type="GeneID" id="13402868"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102532"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1130"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083361_1_0_1"/>
    <dbReference type="InParanoid" id="F9WWN6"/>
    <dbReference type="OMA" id="HPDDQIA"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000012">
        <property type="entry name" value="Probable tRNA-splicing endonuclease subunit sen-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="209" mass="23404" checksum="04BAE93594DFA76C" modified="2011-10-19" version="1">MSSTANVPSQSTLPPLSALQALLITNPLPSSSPHTTEHQHLALQIAHNLKHQHNWTSLRLHTYSSSKTPLSRPLLSGIPPSRLYVHPDEQIALLQRAKEQQPNGTPSLTSLKPEREWILPSHLREKWSLRKFGEVFDGIGVTPGSREGVEVLEEESRGRTGRDVNGMEKEEVGEWREKLPKRVLLATADDDSTVVYYVVHDGVVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXA8</accession>
    <name>F9WXA8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_102988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856817.1">
        <property type="nucleotide sequence ID" value="XM_003856769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXA8"/>
    <dbReference type="GeneID" id="13398428"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102988"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2067"/>
    <dbReference type="eggNOG" id="ENOG502R9VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150129_3_0_1"/>
    <dbReference type="InParanoid" id="F9WXA8"/>
    <dbReference type="OMA" id="HQTTGVK"/>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="80" mass="8161" checksum="F9E6B971BDC44CD5" modified="2011-10-19" version="1">MSTHTTAGLHSETPSNSETAVGGEAGASIVPKASETAPETGDSQQSKSMGSSQPGSAEAAAEKLYEERMEDEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXW0</accession>
    <name>F9WXW0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_107028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856121.1">
        <property type="nucleotide sequence ID" value="XM_003856073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WXW0"/>
    <dbReference type="GeneID" id="13403098"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107028"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.622"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="InParanoid" id="F9WXW0"/>
    <dbReference type="OMA" id="RCDVRNW"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP91097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32482" checksum="424D3FCFAFB0DDE9" modified="2011-10-19" version="1">MQYGPVPDFPVEGKIVVITGGGSGIGFAFARLCHERGARVLIGDLKLVADAERYVAQAPHGAVAFQHCDVTSWKSLHDLILASVSSFGNVPDVYVPSAGVFEPPWSNFWDDNEYEAYKMMQINVNHPIKFTRLAMRALAGAEKRGVVCLIASSAGIRGNYLASLYASSKHAIVGFAKSIGQADVEEGVKVVCVLPGMVQSPLWEDREDDMTTRTQYSERLKTALQPADIADTMLRMVESKEYDGGTCVLKTKFEERVVEEGFIKSTGKYDPSPRPEPNIGRIKEVLHEERGKKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9WY77</accession>
    <name>F9WY77_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_107460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857158.1">
        <property type="nucleotide sequence ID" value="XM_003857110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WY77"/>
    <dbReference type="STRING" id="336722.F9WY77"/>
    <dbReference type="GeneID" id="13395226"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107460"/>
    <dbReference type="eggNOG" id="ENOG502QRAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="InParanoid" id="F9WY77"/>
    <dbReference type="OMA" id="DLPMTQV"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="3">
        <location>
            <begin position="110"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="5">
        <location>
            <begin position="536"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="4">
        <location>
            <begin position="817"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="842"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111538" checksum="66485BD9F566FAA9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYT3</accession>
    <name>F9WYT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_65081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857714.1">
        <property type="nucleotide sequence ID" value="XM_003857666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYT3"/>
    <dbReference type="STRING" id="336722.F9WYT3"/>
    <dbReference type="GeneID" id="13403868"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_65081"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_0_1_1"/>
    <dbReference type="InParanoid" id="F9WYT3"/>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP92690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="14195" checksum="A5338342EC89C270" modified="2011-10-19" version="1">MSSRPFITCHVLDTITGKPGPNIAVKLKLVSPAHLTTAHWNATTNSDGRVTGWTSPADINEVVKSAKGTLADGEQMVWSLTFETEAYFGKGNTFWPEVELRFAAKKEEEHYHVPLLLGPWSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZJ4</accession>
    <name>F9WZJ4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_35093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855869.1">
        <property type="nucleotide sequence ID" value="XM_003855821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZJ4"/>
    <dbReference type="FunCoup" id="F9WZJ4">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZJ4"/>
    <dbReference type="GeneID" id="13403791"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35093"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZJ4"/>
    <dbReference type="OMA" id="TQPNVYQ"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP90845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="275" mass="30727" checksum="12EDFBE3121995CC" modified="2011-10-19" version="1">MGLDGADDDVSETQQPQQEEKTNGQSQSNEETQNPSDSFKLKFCTVCASNNNRSMEAHLRLTTAQPTPYPTISFGTGSLVRLPGPSISQPNVYNFNSTSYASMYDELASKDRRLYSANGILPMLERNKNVKFGPERWQDWRVGVPRTEWGDDKGAKGTEAGTVDVVITCEERCWDAVVDDLLTRGSPLNRPVHVFNVDIKDNHEEALVGGRAILELADKLNEVAVEEREAYVKGGGRGFENGEGRSGFDERVPDVLAEWQERWPNLPALWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZQ5</accession>
    <name>F9WZQ5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_32957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855956.1">
        <property type="nucleotide sequence ID" value="XM_003855908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZQ5"/>
    <dbReference type="STRING" id="336722.F9WZQ5"/>
    <dbReference type="GeneID" id="13403895"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32957"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.274"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="F9WZQ5"/>
    <dbReference type="OMA" id="RHIFHAF"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="190"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP90932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="432" mass="47669" checksum="5E09AD2FAE64AF9B" modified="2011-10-19" version="1">MSAPHPTTLVELAQRMLDYAKQIEAAIPSPTFTKDTMLDLPLDLRAIRTAAISASDEFNDLVRGSRGNDSRMDKYSGNTALAGRLAWHFVNHFRMPQAVPLEAGSQISYAELAEKTGLHVDDLTQILRYATTIHLFDEPSAGHVSHSADSRNLATTPSMCDYISLMTGFHAVANVRYVDACQKWPGSQELNETAFNLAMGTDKPMFQWIEGHPTWPQTFGGAMVERSCGVSDTAGTAAVSYPWDQLGDNCKVVDVGGGNGHICMAIARKQPGIRFVVQDLPEVCHQASQALPKDLQDRITFMPHSYLDPQPVKDADAYFFSMIFHDQSDKYVKITLQQLTAALKPGARVLWCDRYVPEQIGCSDLSRVELQATLGTSLAMKTLLNGRERTLSEKKALFHAADARFKFLAEHKATSGNSFTVAEAIWQPDAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZV2</accession>
    <name>F9WZV2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GTB2401</name>
        <name evidence="20" type="ORF">MYCGRDRAFT_89011</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856060.1">
        <property type="nucleotide sequence ID" value="XM_003856012.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="F9WZV2">
        <property type="interactions" value="1161"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZV2"/>
    <dbReference type="GeneID" id="13403155"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_89011"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="InParanoid" id="F9WZV2"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="20" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt6 acidic N-terminal" evidence="12">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-turn-helix DNA-binding" evidence="16">
        <location>
            <begin position="402"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Tex-like central region" evidence="19">
        <location>
            <begin position="612"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription elongation factor Spt6 YqgF" evidence="15">
        <location>
            <begin position="810"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription elongation factor Spt6 helix-hairpin-helix motif" evidence="14">
        <location>
            <begin position="973"/>
            <end position="1079"/>
        </location>
    </feature>
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        <location>
            <begin position="1090"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6-like S1/OB" evidence="18">
        <location>
            <begin position="1192"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6 SH2" evidence="13">
        <location>
            <begin position="1299"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGP91036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1520" mass="174492" checksum="91E71D585EE58BC4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZW8</accession>
    <name>F9WZW8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">MYCGRDRAFT_35091</name>
    </gene>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
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    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZW8"/>
    <dbReference type="STRING" id="336722.F9WZW8"/>
    <dbReference type="ESTHER" id="zymti-f9wzw8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="13394322"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35091"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.514"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="InParanoid" id="F9WZW8"/>
    <dbReference type="OMA" id="CFYIHGG"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="551" mass="62538" checksum="318B05F0904F81C6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0I8</accession>
    <name>F9X0I8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_102849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856654.1">
        <property type="nucleotide sequence ID" value="XM_003856606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0I8"/>
    <dbReference type="STRING" id="336722.F9X0I8"/>
    <dbReference type="GeneID" id="13398811"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_102849"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1721"/>
    <dbReference type="eggNOG" id="ENOG502SSWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093242_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0I8"/>
    <dbReference type="OMA" id="YVNAKRH"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391183" evidence="2">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="285" mass="29844" checksum="D4C7440AAFDA7C81" modified="2011-10-19" version="1">MVNSFVASLALFGASASALGAGHVVNKCDYDVYTSVVPASGGGQETKMLTLSPGDSWDQSWTPLTNGAGWSIKFSKEEGSFGSNILQFEYTSQNDGTLWYDLSCVDGTPWQKDWHISSDTDDCIPKQAAYRFSTDDAHGMQNGCPCEASITVTLCSSNSGNSTSGDNKPSGGDNKPSSGDNKPSSGDNKPSSGDNQPAQGTQPSSSSSAAAEPPVYTPPPYVAPALPTTLSTSTLVASQTVDNNYVATVVETVYTYATAAVSQGEDGVLHVNPKRHQHHPHGHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0T0</accession>
    <name>F9X0T0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_19556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <feature type="domain" description="HMG box" evidence="8">
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            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X136</accession>
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            <fullName evidence="3">NAD(P)-binding protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Ware S.B."/>
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            <dbReference type="PubMed" id="21695235"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24407" checksum="8FAA8DD7D4037C91" modified="2011-10-19" version="1">MPIAVVTGANSGIGHALAQLLISEGYEVHAADHILGPTLQSLPCRLHRLDLRSPVSIAGLATHLASKPIHILLNVAGVMSPKEDDALPTVTKEILTTTFETNAFGPLLLTQALLQSLLLGAEDADGGGAKVGIVSSRVGSIGDNSTGGSYAYRASKAAVNSVGKSLACDLQSQGIVVSLLHPGITKTNMNPAADADPEAVEAEEAAAKLWAIMKEKGIEDTGKFWHREGHELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X158</accession>
    <name>F9X158_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_66624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857205.1">
        <property type="nucleotide sequence ID" value="XM_003857157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X158"/>
    <dbReference type="FunCoup" id="F9X158">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X158"/>
    <dbReference type="GeneID" id="13395094"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66624"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1325"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="InParanoid" id="F9X158"/>
    <dbReference type="OMA" id="YTLWIIV"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="95" mass="10366" checksum="66C8D2CC72C38F33" modified="2011-10-19" version="1">MGANNTLDRLVGLAMLILASAVFLYYTVWTLLMPFVDDSHPIQSLFPPRVWAIRIPVILILLGGAVVGSFLSVVMIRSNRKKALKAKKAAAGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1A9</accession>
    <name>F9X1A9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallothionein-I gene transcription activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_78914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857108.1">
        <property type="nucleotide sequence ID" value="XM_003857060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1A9"/>
    <dbReference type="FunCoup" id="F9X1A9">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1A9"/>
    <dbReference type="GeneID" id="13395362"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_78914"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1544"/>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1A9"/>
    <dbReference type="OMA" id="MTYICGD"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP92084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9622" checksum="D359B102C13E3F19" modified="2011-10-19" version="1">MSREAYTPPALTSDAITIGSGAQQAPQGSFAITGAGSFEDTSKPVHYLCGDCDTKVSLKKGDPIRCKECGYRVLYKERTNRMIQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1C4</accession>
    <name>F9X1C4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_19271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857102.1">
        <property type="nucleotide sequence ID" value="XM_003857054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1C4"/>
    <dbReference type="STRING" id="336722.F9X1C4"/>
    <dbReference type="GeneID" id="13398965"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19271"/>
    <dbReference type="eggNOG" id="ENOG502S9ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092507_1_0_1"/>
    <dbReference type="InParanoid" id="F9X1C4"/>
    <dbReference type="OMA" id="DNEMRTR"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="100" mass="11111" checksum="CF85AEC9C8393F77" modified="2011-10-19" version="1" fragment="single">TRTQEEARAAVLASLSSAGSFHDSKYLTRASDLHANSSAIAKQESELLKSSKALAKESDKWQKELDKATKGVKEVGDLQNWAEMLEREFCVLEETLRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1F6</accession>
    <name>F9X1F6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_53956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857085.1">
        <property type="nucleotide sequence ID" value="XM_003857037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1F6"/>
    <dbReference type="FunCoup" id="F9X1F6">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X1F6"/>
    <dbReference type="GeneID" id="13395386"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_53956"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1592"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="InParanoid" id="F9X1F6"/>
    <dbReference type="OMA" id="DGWVNIH"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP92061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="356" mass="38055" checksum="6B4C842E5EE91F5F" modified="2011-10-19" version="1">MSKQPWIETPLIWSKGLSRICGCNIYLKLENTQPSGSFKSRGMGAFVKAHLPDDGANGTGDSRTTTHFFCSSGGNAGLGCVSAAVTFICPATIVVPDSTSAYMIDKLKKAGAHEVIQTGASWYEADQYLRKELLPAARAGGQHAVYVPPFDDPAIWAGNSTMVDEIVQQLSTVDDHYPSATRESGTESVTLPDAIICSVGGGGLLNGIMQGLERHSAWKGETGPMVLAVETVGADALSQSVEKGELVTLPKITSIATTLGARRVSEQTFTYAMDRTRVKCAVLTDKETVEACKRFADDERMLVEPACAVSLAVLYTGKLHEYIPGLQPESRVVVVVCGGSGLSLQILNQYIKDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1Q7</accession>
    <name>F9X1Q7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_90306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856839.1">
        <property type="nucleotide sequence ID" value="XM_003856791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1Q7"/>
    <dbReference type="GeneID" id="13398397"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_90306"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.2110"/>
    <dbReference type="HOGENOM" id="CLU_1679342_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1Q7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP91815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="157" mass="17327" checksum="CAD7BAA6F39E2D6D" modified="2011-10-19" version="1">MRHFEPKDNLNQYLRTFDKAPYLCFDIDEETTACCRNKVLEVALTLGDRDALAGSFSKAGCLNVPGYCNGIGFTTNSGSRSDIRTEKLTKHNDMCLFDGDCGSCSKRYSLAASDLKDNLITGIPPVTGNNVDLNVEEPGTWRLSNVLGTERHGRAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X1V5</accession>
    <name>F9X1V5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_108265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855126.1">
        <property type="nucleotide sequence ID" value="XM_003855078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1V5"/>
    <dbReference type="STRING" id="336722.F9X1V5"/>
    <dbReference type="GeneID" id="13400748"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108265"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.984"/>
    <dbReference type="eggNOG" id="ENOG502S35J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_2_0_1"/>
    <dbReference type="InParanoid" id="F9X1V5"/>
    <dbReference type="OMA" id="RPNAEQW"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="567" mass="61691" checksum="2E2C9399F2793B3B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2K2</accession>
    <name>F9X2K2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_103029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855789.1">
        <property type="nucleotide sequence ID" value="XM_003855741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2K2"/>
    <dbReference type="GeneID" id="13395915"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103029"/>
    <dbReference type="HOGENOM" id="CLU_2374393_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2K2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="95" mass="10563" checksum="531047779C45A799" modified="2011-10-19" version="1">MAASHSPKLGARSRPGMQGSGDADRESNISKRRVFEMEKEMLTGTGSVRRGAQLIHTCRFRRCCAQSQHQHPTHVGEERADAYQTGTCVMLPQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2V6</accession>
    <name>F9X2V6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_99117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855559.1">
        <property type="nucleotide sequence ID" value="XM_003855511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2V6"/>
    <dbReference type="STRING" id="336722.F9X2V6"/>
    <dbReference type="GeneID" id="13403499"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99117"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_6_0_1"/>
    <dbReference type="InParanoid" id="F9X2V6"/>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="130"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="38301" checksum="A9C4E27883ECF97A" modified="2011-10-19" version="1">MDSASTDDPIATLIETYHELNSSIVQELSDEPSPLEFMRYVARNRPFVVRNAARDWPAVRKWDTKYLRRVLHRQDVRVAVTPKGNADAVVSDQDIGLLFAEPHEIVEPFEDFLAYVQEDSSSSDTTMNVKYAQPQNDSLRTEYSSLFADVPPAISFATIALEQDPDAVNFWLGNSRSTTSIHKDNYENIYVQIRGQKHFTLLPPIEMPCVNETPLPFGRFHPSPENGGKLEARINADDDELRPVPIWDPDEPDVRSTRYSKLSRPLRVTLNEGDMMYLPALWYHKVGQGNGEEGFACSVNYWYDMEFGGGFWASNAFVRDVKRCNSSSESDEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X2W7</accession>
    <name>F9X2W7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_21898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854932.1">
        <property type="nucleotide sequence ID" value="XM_003854884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X2W7"/>
    <dbReference type="FunCoup" id="F9X2W7">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X2W7"/>
    <dbReference type="GeneID" id="13399572"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21898"/>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039081_0_0_1"/>
    <dbReference type="InParanoid" id="F9X2W7"/>
    <dbReference type="OMA" id="PKYKFAA"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="404"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="487" mass="54424" checksum="3612BD462736A6AF" modified="2011-10-19" version="1" fragment="single">NGSLPLKGVVLCCTSLAQEVRTSLAEAAVSMGAVHKLDLTSDVTHLIVGSITTPKYRYVAKERPDIRVLAPSFIDAIRHEWMKGGAVDVETLLDQHTLPPFSGLMICLTGWQDLETRRRFEETIRKNGATYNADLVKQVTHLIAAKPEGAKYTHAKQWGIKVVGLRWFEDSLKRGMALDESLYQAEMPEETQGKGAYRTEPKKPLVKRGRETDLAAGIEEAGRRKLRKVASMRLDQHSQDLWKSVSEHEVQVETTEIDVWNEESQTMQNHAPAGEQQTKRGTESLRTSRNGPSDAGESLLSGIYILLHGFDKLRRERLMHFLEPNGAIVVDCHDALARASENQSFHSRILLVPHADQEKLPDVPPATTVATEWWVERCVHHKRNLDPDQDPLSQPLGQVTVSGFSGVAITTTGFDNVDLRQTAEAVKLMGATYQEQLLPSTSVLVCGDKLVRKEKAFYASKHNIPVVSAKWLWESLRLKTKAPFDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X346</accession>
    <name>F9X346_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_68702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855434.1">
        <property type="nucleotide sequence ID" value="XM_003855386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X346"/>
    <dbReference type="STRING" id="336722.F9X346"/>
    <dbReference type="GeneID" id="13400981"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_68702"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.822"/>
    <dbReference type="eggNOG" id="ENOG502QW99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036449_0_0_1"/>
    <dbReference type="InParanoid" id="F9X346"/>
    <dbReference type="OMA" id="GGWYYQS"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391266" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="74"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP90410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="430" mass="47564" checksum="1ED71EBD9147D8CA" modified="2011-10-19" version="1">MYTSTQHLAVAFLAIGSVAAAPAARDHHAEQPLTSSIRNVQVGPRPFWLIDNMDEGPLKEKLQSCQENTLKTTQFAISHRGAPLMFPEHSKEGYDAAARMGAGIIECDVSFTSDRELVCRHSNCDLHYTTNVLSKPELAAKCTKPFVPYNNVTGENASAKCCTSDFTLAEFKSLCAEMEATTLHAMNITSAAPYFGRIGTTPDWRTNLYAYECATPVSLKEQIAQVQAYGLNFTAELKTPEVKMPFQGNYTQQIYAQQLIDTFKELNISPDRVWLQSFLADDIFQWIDTEPEFARQAVYLDERADKTPEGYQEAVASLPGLAARGVKIIAPSIYQLITADNCTDTIVPSSYAIAAQKAGLEIITWSFERSGPFSIEDGGYYYSSVKNLIATRVLKNEFTVLDVIAQQVKATKVFSDWVGTASYYGNCFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3K7</accession>
    <name>F9X3K7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_107972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855642.1">
        <property type="nucleotide sequence ID" value="XM_003855594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3K7"/>
    <dbReference type="STRING" id="336722.F9X3K7"/>
    <dbReference type="GeneID" id="13399360"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107972"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.395"/>
    <dbReference type="eggNOG" id="ENOG502S8J5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801643_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3K7"/>
    <dbReference type="OMA" id="RAYHEFH"/>
    <dbReference type="OrthoDB" id="5397628at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="306" mass="34205" checksum="042B177156745704" modified="2011-10-19" version="1">MASLMRIVNRLLPFATPGTPLLQDLVHLGVICALLYFAPQIQERLQKQLPEQRHEGEQPQVIQDDPIPDAGVQPEADDVDDQHDADNIIDNEEAPRVPNEGEAGPAHAPMMPPQRNVGAKKAKSLARRDQKRAYNEFMRTQGEAQRAKDAEGAAEREAEQEAERERRKAAAATVEAKKAKEREQRREQERKAREGEISRRDTVLSIARRELEEMRMVNLFDVASRVGGDADEIWVERILNAGGILGWSNDGSALTTVTSTGWVIRVSRDDMMQVYDRASNQGDATGRIKPHQIGSLLEAVLREQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3M7</accession>
    <name>F9X3M7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_99130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854950.1">
        <property type="nucleotide sequence ID" value="XM_003854902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3M7"/>
    <dbReference type="FunCoup" id="F9X3M7">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X3M7"/>
    <dbReference type="GeneID" id="13403479"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99130"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.602"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="InParanoid" id="F9X3M7"/>
    <dbReference type="OMA" id="QPLVMEN"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="47"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="366" mass="39433" checksum="EEC442AB7AB9FC18" modified="2011-10-19" version="1">MSAQENADDVRVLGQDPLIPPQLLTSELPAPANSIPTVLRGRKEAVEIIKQRDDRLLVMVGPCSLHDPATAVEYCTRLVSLASRLQSDLCIIMRAYLEKPRTTVGWKGLINDPDIDESYQINKGLRVSRKLFCDLTEQGMPIASEMLDTISPQFLADLISLGAIGARTTESQLHRELASGLSFPMGFKNGTDGSLTVAVDAIGAAAAKHHFMGVTKQGLAAITKTAGNPDCFVILRGGTKGTNFDRESVKATREALKKKSLGEVMMIDCSHGNSQKDHKNQPKVAQVVGDQIREGETGIVGVMIESNIHEGNQKVPATGGLAALKKGVSITDACIDWDTTVQVLEQLADAVRTRREVNKGKTNGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V8</accession>
    <name>F9X3V8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_36277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855071.1">
        <property type="nucleotide sequence ID" value="XM_003855023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V8"/>
    <dbReference type="STRING" id="336722.F9X3V8"/>
    <dbReference type="GeneID" id="13399862"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36277"/>
    <dbReference type="eggNOG" id="ENOG502RY7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103452_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3V8"/>
    <dbReference type="OMA" id="YELVMIN"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="148" mass="16634" checksum="6AC111FCF6DBB87E" modified="2011-10-19" version="1" fragment="single">QADLAPKLPAHSSILFAQKKAKNLSFETIGKELGREEVAVAALFYGQSNATDEDVTKLCQILDIPEDALRATEITSLPDRGRSMEMPPREPLMYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDDKGDWVKITLRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3V9</accession>
    <name>F9X3V9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_108195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855072.1">
        <property type="nucleotide sequence ID" value="XM_003855024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3V9"/>
    <dbReference type="GeneID" id="13400014"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108195"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.855"/>
    <dbReference type="eggNOG" id="ENOG502R9MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657499_0_0_1"/>
    <dbReference type="InParanoid" id="F9X3V9"/>
    <dbReference type="OMA" id="EAYCKVF"/>
    <dbReference type="OrthoDB" id="3650348at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="421" mass="46358" checksum="2A79C425C4F74141" modified="2011-10-19" version="1">MARDKKRQKIARDITAAHAPSQKIDRETTAAYAASQPLFDALRNGAANVDAQRDNLAKARDLVQQVHVKIATEDVPSHEQYMENIVEAWQSATTIFCQVFSELTSITAAEPSEGREAGKAHGQFMSMLDTAQTARDVAIAYAPGSANSEGAGKAATVESDDESEEEEVVSSPTKAKPDTKTSTTALPKGKAKRTFEQLNTDALPPTPATDGNKLSRSDRRQSWKKAELAKKNTKEPQPEDNTDGQAAHKPAPEVTSNPQPAVKFEDFSHLVEARIKSKLQPAVEFEDVSHLVEARIKAKAEKAAEKKKSKLKTEKKRKRESGDSFAAMAEEKVHEPIKTELTVEKPKRKKSKKVAPEVDDILKSADADKVKHKEKTADRKADVKHEKHAAPKDKPEKRKTDVEQVEEGEKPAGKKRKKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3W9</accession>
    <name>F9X3W9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_108201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
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                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854413.1">
        <property type="nucleotide sequence ID" value="XM_003854365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X552"/>
    <dbReference type="STRING" id="336722.F9X552"/>
    <dbReference type="GeneID" id="13395600"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_69852"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="F9X552"/>
    <dbReference type="OMA" id="WTFRHRI"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="572" mass="63449" checksum="4DDEB0AE0997DEEB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5T9</accession>
    <name>F9X5T9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_18838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854025.1">
        <property type="nucleotide sequence ID" value="XM_003853977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5T9"/>
    <dbReference type="STRING" id="336722.F9X5T9"/>
    <dbReference type="GeneID" id="13404364"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18838"/>
    <dbReference type="eggNOG" id="ENOG502RQMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103863_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5T9"/>
    <dbReference type="OMA" id="IFKCNEW"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="139" mass="15614" checksum="AF9FAA9455096CE7" modified="2011-10-19" version="1" fragment="single">PAKRYHDGVFVETDRTNGTGTMFHVTGDIIAQSGMRYEEKENWVPGQSARLHRITPIGFVNEDDVDSDKISSVLRSLPTPTKQQGVNFWKRSSEPGAIEIIWTKEDGEPYGAGEGRRPVIKCNEWTDLAIQTLRSRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X602</accession>
    <name>F9X602_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MgOPT4</name>
        <name evidence="11" type="ORF">MYCGRDRAFT_39492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853648.1">
        <property type="nucleotide sequence ID" value="XM_003853600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X602"/>
    <dbReference type="GeneID" id="13403986"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39492"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="InParanoid" id="F9X602"/>
    <dbReference type="OMA" id="HCFLFWG"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP88624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="773" mass="85356" checksum="718994DA65243039" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7B2</accession>
    <name>F9X7B2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_37911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853947.1">
        <property type="nucleotide sequence ID" value="XM_003853899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7B2"/>
    <dbReference type="FunCoup" id="F9X7B2">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7B2"/>
    <dbReference type="GeneID" id="13395511"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37911"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="InParanoid" id="F9X7B2"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="157" mass="17016" checksum="3E468389AAA46D74" modified="2011-10-19" version="1">MLTRAVNSIRRHQVNRFHSLIVHRSNVHKLTLSNSLVGTGNLDKAAIFNSEGNSVWATSAGFQVSPQEMQAIVAAYKDPGTDGVKKVQSEGLHVAGERFVVIKADDRSIYGKKGREGVVIVKTTQAILVTHYPESVQPGAATNTVETLGDYLVKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7B4</accession>
    <name>F9X7B4_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854323.1">
        <property type="nucleotide sequence ID" value="XM_003854275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7B4"/>
    <dbReference type="GeneID" id="13404287"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_39154"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9X7B4"/>
    <dbReference type="OMA" id="CYFAVHV"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="518" mass="57312" checksum="623CEE1D2C5C853E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7R2</accession>
    <name>F9X7R2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_37784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854461.1">
        <property type="nucleotide sequence ID" value="XM_003854413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7R2"/>
    <dbReference type="FunCoup" id="F9X7R2">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X7R2"/>
    <dbReference type="GeneID" id="13395647"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37784"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="InParanoid" id="F9X7R2"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP89437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="480" mass="52258" checksum="797778A96B5F5207" modified="2011-10-19" version="1">MSSSSSNNKILEGVFGTVRFHQPSFLPSTNPSSPAIAKPPSITSAQVIRSVQQHFEPSSLFAPWLAREKTRQQAESANQKTKRKWRGRRAASVKMGHGGTLDPMATGVLILGVGAGTKQLGYYTTGCTKSYETVVLFGASTDTYDVEGKVIARKAFEHITREKVETALAAFRGKIQQKPPIYSALKVQGKKMYEYAREGKEVPGEGIKERSVEVLELDVVEWWEGGEHEYRWPEEAVAEEVEEKVMGDGEGAVQEPVAGQKRERSQEEDDSSAQPTTTEAAEPPAKRSKPDKTPPPSPKKSKKYYSAPPPTSQTHLPRCPAPAVRLRMKVTSGFYVRSLCHDLGVAVDSLATMARLVRTQQGDFELGKNVLDFEDLEKGEEVWGEKVRGMLGGGDGDGVKGEDVEVEVEENAVEAKNEQGTRSGQASAVKTAEAVEQTEGGAAQSSNAILERDAAEAAEQTSTEKEDARRAELLASRGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7V3</accession>
    <name>F9X7V3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_91684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853823.1">
        <property type="nucleotide sequence ID" value="XM_003853775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7V3"/>
    <dbReference type="GeneID" id="13404161"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91684"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.489"/>
    <dbReference type="HOGENOM" id="CLU_1397340_0_0_1"/>
    <dbReference type="InParanoid" id="F9X7V3"/>
    <dbReference type="OrthoDB" id="10286643at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="21086" checksum="C44F47657C27B177" modified="2011-10-19" version="1">MASTDALHIERTADHNHDHAMAYREGVNLESATCRPRISRTGSAGKALTDAGEDVQKDLTLSRKDSKGSPSMQVTVEECETDHSKSEEAGDAERAHESDESNARTCSGSIHSNGLQVIPDGKARVRAYSSSMARLAEDSLKGLNIAKESSDARSALALRNGLADPMLPVKSVWSPESEPDSYGFEMQAKYYADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8D9</accession>
    <name>F9X8D9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_92440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852926.1">
        <property type="nucleotide sequence ID" value="XM_003852878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8D9"/>
    <dbReference type="STRING" id="336722.F9X8D9"/>
    <dbReference type="GeneID" id="13400460"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92440"/>
    <dbReference type="eggNOG" id="ENOG502SG9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1636761_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8D9"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033388">
        <property type="term" value="P:putrescine biosynthetic process from arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF15">
        <property type="entry name" value="FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="162" mass="17617" checksum="EE1E33715C1906EB" modified="2011-10-19" version="1">MSGLNGLNKSSPSSIIIGACQSQLFPVHTPSQLASAVQHVVSLVSKARRAYPLMDLIVFPEYCIHGLSMSTSPSILCTLDGPEVLQFQQACIANTIWGCFSIMEPNPLLPSAPWNTGLVINPAGEVVNYYRKLHPWTPVEPWYPGNRGVPVFTGPNGRWDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8I7</accession>
    <name>F9X8I7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_58104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853383.1">
        <property type="nucleotide sequence ID" value="XM_003853335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8I7"/>
    <dbReference type="STRING" id="336722.F9X8I7"/>
    <dbReference type="GeneID" id="13397350"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_58104"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.499"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_4_1"/>
    <dbReference type="InParanoid" id="F9X8I7"/>
    <dbReference type="OMA" id="GERIPVM"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="212" mass="23809" checksum="80D0996C4DB9C24A" modified="2011-10-19" version="1">MDDPPVVPILLLGDSGVGKSTFLSRLSVGHKSTAPLPRMRDLEQPFVFNISMYNRPYRFEFYDTASSENYTLLKPAVIILCYSIADPASLVNIREKWMNLVDTNYNVDEQLPIIILGLQRDVRSEEDYSGRVRQQATTSGESEDDDVVLNGRTFVYPQEGLRAAQEMRCDRYCECSALTGELCREVIEDISKTAAKTTTEKGGRSEGNCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9T2</accession>
    <name>F9X9T2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_92915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853181.1">
        <property type="nucleotide sequence ID" value="XM_003853133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9T2"/>
    <dbReference type="GeneID" id="13399545"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92915"/>
    <dbReference type="HOGENOM" id="CLU_912792_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9T2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="305" mass="32513" checksum="567F5B5D1B221FF1" modified="2011-10-19" version="1">MACLLLPSSRMKRLAKYANILIGANIAIVELALAQDLRLCDSIGDRLLSVTETLDNHAMRTKAPLPQILDAALSPHFQVVPTRTTAAASSSTTDEDAGEQGKINLLAMIGQVEVEWLEAPSTGSTVMLGSVDMPIIVVAIMVALLERLVASLDGIGTTTNPAPTSSLISAGRNVLLESGSCRPSIRPANRAATSPLDFGCVIVLAAPEWAYTRSFTRQVGHKRQRITLSTQTTAINQCDAETNHQCCEPFDRPNSKCGNKRTIVCWAGSNSECGRGCDGSYRGGITVQLPGLGEINNVQEKIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9V6</accession>
    <name>F9X9V6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SDH4</name>
        <name evidence="13" type="ORF">MYCGRDRAFT_57478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853609.1">
        <property type="nucleotide sequence ID" value="XM_003853561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9V6"/>
    <dbReference type="SMR" id="F9X9V6"/>
    <dbReference type="FunCoup" id="F9X9V6">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9V6"/>
    <dbReference type="GeneID" id="13397115"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_57478"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.7"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="InParanoid" id="F9X9V6"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="193" mass="21013" checksum="C9A0FA5093598D41" modified="2011-10-19" version="1">MASTALRPAALRQLLTATTTKRASTLPAASLLRTQFTQRSGFQTTARRPILPPLPQVIRGGVNDPAPVKEPSPSHGSYHWTMERLVSAALIPLTIVPFAAGSLNPVLDGTFIGMIIIHSYIGFQSAITDYFPSWRVPKTRKLADWANVAAVFLVGWGWYEFETNDIGLTAGIARVWTAGATAKDAKNKIEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB69</accession>
    <name>F9XB69_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_72668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852392.1">
        <property type="nucleotide sequence ID" value="XM_003852344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB69"/>
    <dbReference type="FunCoup" id="F9XB69">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB69"/>
    <dbReference type="GeneID" id="13394197"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72668"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="InParanoid" id="F9XB69"/>
    <dbReference type="OMA" id="CRNAAMR"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="151"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="432" mass="47764" checksum="3B479BE522ABC8D3" modified="2011-10-19" version="1">MGISERKHGQWILDFALVAAAPLLAFFLARTLIARLDPDAQAKSEAQQKALAATSRLQSIFTPQERDDFDDEDEDGDGHPPTQDDRLRNQDLVLSQYEQTIAMEVVSPSDIPVTFKDIGGLDEIIEELTESVIYPLTMPHLYSNHSSLLSAPSGVLLYGPPGCGKTMLAKALARESGACFINLHISTLTEKWYGDSNKLVAAVFSLARKLQPTIVFIDEIDAVLGQRRSGEHEASGMVKAEFMTHWDGLASSTVDDGTQRICILGATNRIQDIDEAILRRMPKKFPVSLPNNAQRRQIFELTLRDTKIDARKLPNGSAAFDVNTLVRLSAGMSGSDIKEACRDAAMVPVREYIRNAKSSGKRMARVKGDDVRGLQTEDFFGRKGAMEQMQTQASSRQRINDSEEDQRSDASGSTEEVEEFGDVEDVVDAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBU1</accession>
    <name>F9XBU1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyl xylan esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_41428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852304.1">
        <property type="nucleotide sequence ID" value="XM_003852256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBU1"/>
    <dbReference type="GeneID" id="13394079"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41428"/>
    <dbReference type="eggNOG" id="ENOG502RYKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_3_0_1"/>
    <dbReference type="InParanoid" id="F9XBU1"/>
    <dbReference type="OMA" id="NWRNECT"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl xylan esterase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="187" mass="20697" checksum="E8181BF820DCD57D" modified="2011-10-19" version="1">MPSKDIELKTSDNITLRGWFVTPASFDGKLPCLVMAHGWTALKEMDLNTFADYFTSSLPISCLVYDNRGFGDSDPALGQPRHEIIPQLQQSDYSDAITYASSLPEVDPERIGLWGSSYSGGHVLYVGAVDRRVKAVLSQLYSLLTNGWENFNRLIRPDFAGGMNTSFAEGMSLFVLLRMPASCSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCE9</accession>
    <name>F9XCE9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_42801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852458.1">
        <property type="nucleotide sequence ID" value="XM_003852410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCE9"/>
    <dbReference type="STRING" id="336722.F9XCE9"/>
    <dbReference type="GeneID" id="13394133"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42801"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.741"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="F9XCE9"/>
    <dbReference type="OMA" id="DPDLHWK"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="288" mass="30766" checksum="48C6EA7CEE52FBB7" modified="2011-10-19" version="1">MPPISFKPSKLTQPQPPTKHTLISYPSPGVLLVTINRPKELNCLHTAANHELEAIWSWLDVEPSLSVGILTGTGRAFCAGADLKEWNAANKSSTPRTMPPSGFGALSRRSGKKPILAAVNGICYGGGCEMIINADMVIASSRATFALPEVKIGVVAAAGALPRLIRTVGKPRAMEMALTGRPVSAREAERWGLVNCVVEDGEEKGSRQGEGVVAKAVELAGLIAGNSPDAVRVSREGVMLGWEGIGVEEGTERVLEQWMPKLSKGENLKEGVRAFVEKRKPKWVASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCG8</accession>
    <name>F9XCG8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_28957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003852398.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XCG8"/>
    <dbReference type="GeneID" id="13394139"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_28957"/>
    <dbReference type="eggNOG" id="ENOG502SBR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCG8"/>
    <dbReference type="OMA" id="IKGWQKA"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="16325" checksum="98302E2A6AEB1B05" modified="2011-10-19" version="1" fragment="single">PIEQPWHAAFSPPTLVAPLMPRNRVHQILSLKIGNLLIIDTRRTDYLGGSIRGSLNVPAQGFWWNRGALYELAYKADIEWVVFTCGSSNGRGPRCAGWFLDHVRKTAGDENMQVCVLEGGVKGWVKAGEEYTRLMDGFDGEYWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCH4</accession>
    <name>F9XCH4_ZYMTI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852365.1">
        <property type="nucleotide sequence ID" value="XM_003852317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCH4"/>
    <dbReference type="STRING" id="336722.F9XCH4"/>
    <dbReference type="GeneID" id="13394142"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93532"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.767"/>
    <dbReference type="eggNOG" id="ENOG502SA5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152366_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCH4"/>
    <dbReference type="OMA" id="FRRTELW"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP87341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="297" mass="34218" checksum="C9A00081656099CC" modified="2011-10-19" version="1">MSKGVGATKRKKALKARAKQDNRKVAKKLAQFIEALPRVSEDDLLSFQSAHFGDDSKPDKWFIRPEEAVDYQPVWDDGLGWYEDGVKRTLTDEEIAVFRRTEEWQLERAEEIRRREAEGERVADGNDEAVESELIDDPIVQADEDFRVLPEEDLRVQPDEDSRVEADQDLRAKSPASSVSSLEEDLMEYAGITKTDPNPRTESRPSKSSYPRPASRASHDSRSGTSNSILGSNQSTSRSKRKKKKPRGQTEVPYDQRHKRKWETFIQDQDPIEGSLTHRRLARELDDQKERRVEMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCT2</accession>
    <name>F9XCT2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_43383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851387.1">
        <property type="nucleotide sequence ID" value="XM_003851339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCT2"/>
    <dbReference type="STRING" id="336722.F9XCT2"/>
    <dbReference type="GeneID" id="13393712"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43383"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="InParanoid" id="F9XCT2"/>
    <dbReference type="OMA" id="QSCLHAN"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="431" mass="47480" checksum="F11985465E201426" modified="2011-10-19" version="1">MEPGTNWTPLDIAVIGGGVGGTAASIALRRAGNKVTVYERADFAGEVGASISCAANGMKWLHEWQVNIEKGDGVYLKQLINRDWKTGEPVSVVDLSDYEEKWGQATIRFHRQDMHKMLMDCALSKEGDGVPVKLVVNHKCEDIDTNSGTVVFTDGSSVKHDVIIGSDGIGSAIRKLIGIQVEKRPAESSCLHANVTSEEAVALGLPSYGEMNSAIEYWGGHGSLNKIVLSPCRNSSLLSYYCFFPREKGDYSRQTWTSEDRPVGELLSPYPDLDPEVYGHLKIGQEIRPWRLWVHEPYSHWQKGLACIMGDAAHPMMPDQSQGACTALEDAAALGLLFSKDFYAGSVEETLKLYEKVRMPRATKVQAASARARENIHERIGFSDNTDNKLYAVNDESSKLTIAEMNSYDMRADILSKWPVSAQTSVTTNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCV7</accession>
    <name>F9XCV7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851925.1">
        <property type="nucleotide sequence ID" value="XM_003851877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCV7"/>
    <dbReference type="STRING" id="336722.F9XCV7"/>
    <dbReference type="GeneID" id="13401385"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93741"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.175"/>
    <dbReference type="HOGENOM" id="CLU_1662199_0_0_1"/>
    <dbReference type="InParanoid" id="F9XCV7"/>
    <dbReference type="OMA" id="MSRDQYN"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390393" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="159" mass="18014" checksum="380B4EA0E5A21A43" modified="2011-10-19" version="1">MHLSTSLVLVLAGSALAAPIQNVEARSYEALGAYYPIPEIQMKRNAELKRAAEPQRGGIMEYIKRDPEAQRGGIMDYIKRDPEAQRGGIMDYIKRDPEAQRGGIMDYIKRDPEAQRGGIMDYIKRDPEAQRGGIMDYIKRDPEAQRGGIMNYIKRDPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XD40</accession>
    <name>F9XD40_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_86451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851881.1">
        <property type="nucleotide sequence ID" value="XM_003851833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XD40"/>
    <dbReference type="GeneID" id="13393658"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_86451"/>
    <dbReference type="HOGENOM" id="CLU_1086677_0_0_1"/>
    <dbReference type="InParanoid" id="F9XD40"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="29503" checksum="C86218FAA497B60D" modified="2011-10-19" version="1">MPYVNPNCSFLSSSSSDAFALAVHPLPSNAVLQPPLPDEERYEGRYNGTLSYAIRTQIKTLKPNRIIEYVTSRAEGRRVTYKQIRKRLDLACLIDTIRRRLNERSYFKRVARLIRRTNKAFNPDCLRPKYKRIKTQLVYSFINAKSLKDYIILELHRFWRKCSNAEAALRLQEQFNTGRFDGFVNKSTFSIDGRFRSLTPIVEDAIVDDAVNGDVDIPAIVDDTMLLLILDGASVYKAATFRSKLDRLRIPYGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDJ2</accession>
    <name>F9XDJ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ACP1</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_43420</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851528.1">
        <property type="nucleotide sequence ID" value="XM_003851480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDJ2"/>
    <dbReference type="SMR" id="F9XDJ2"/>
    <dbReference type="FunCoup" id="F9XDJ2">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDJ2"/>
    <dbReference type="GeneID" id="13401587"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43420"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDJ2"/>
    <dbReference type="OMA" id="FMSSHDD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="141" mass="15300" checksum="B989A3C7F5E3BCA8" modified="2011-10-19" version="1">MFRNALLRSARCVAQQTSVRAARPAVRTALRSPFITSRVSAPATSISAIRCYASSAGLGQEEVTGRILDLLKNFDKLSANAHFTNDLGLDSLDTVEVVMAIEEEFSIEIPDKEADAIHSVNQAVDYIMKQPDGTRGPLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEU8</accession>
    <name>F9XEU8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850860.1">
        <property type="nucleotide sequence ID" value="XM_003850812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEU8"/>
    <dbReference type="GeneID" id="13397598"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94732"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.683"/>
    <dbReference type="eggNOG" id="ENOG502RW5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861105_0_0_1"/>
    <dbReference type="InParanoid" id="F9XEU8"/>
    <dbReference type="OrthoDB" id="3824580at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="323" mass="35530" checksum="B070D5E03F1A0773" modified="2011-10-19" version="1">MAATPTMQIVSISGQTQTTRSIPLAKMVRLSNLARHIVQVTTPGRIPTMILRQTEVDLVAAERILDWIDAYDVEAPVAEQHLELMHLGTDDFNELVAMYAACNFFRVPRDLRGDALRDNIWHYIKRVGRLSANEFIMLYELLPFDFSIQKAIINDFFWARVRGATYTKYRSPADQDAEIEAYLKDVGVWEEVKVIEEEQKVHWANSLERQAKQRAWVVAENKAWADDRTEVNVQHHLSGEQRNGTGVDLDRSVAAGKRGMVIAGGGHGGGGGDLNGWVDSQLEGAGGNVGAGNGGQIEGGEFRGSGGGDLSGWVDLQLEGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF84</accession>
    <name>F9XF84_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850909.1">
        <property type="nucleotide sequence ID" value="XM_003850861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF84"/>
    <dbReference type="GeneID" id="13397647"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94811"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.785"/>
    <dbReference type="HOGENOM" id="CLU_056058_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF84"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="264" mass="29869" checksum="CFEF4A0ED7D2FBCE" modified="2011-10-19" version="1">MANILDVPEVSEALINILLPDVHIVVHRKKNYTHANDQYHISWCNAAEWATFLRYSSTNSTTRARCNQALQHGLQHGTIKLIMDMARHPVHPGRRRANHLLDPPPPMWLLQSITRLEVLCPYTADDMPAWEFGPETETAMMQVSTIYRLFPPNAPGAPLPGQNDIILGVNWKLLYSSAPNPSGLARVAAYEIEWAIRNQLHSAPVPFLPTVNAKGLYNLGILFAIKASKFAQFKECYYYDEPRFNVTVHAVAVDYQRWVEAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFH5</accession>
    <name>F9XFH5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_110299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850932.1">
        <property type="nucleotide sequence ID" value="XM_003850884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFH5"/>
    <dbReference type="GeneID" id="13397690"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110299"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.829"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9XFH5"/>
    <dbReference type="OMA" id="NAIVIMF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="60"/>
            <end position="79"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
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        <location>
            <begin position="129"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="480"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP85908.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="56545" checksum="534F44588CFB2227" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="120" mass="12556" checksum="39D6D6C0B0ED5EA1" modified="2011-10-19" version="1">MYSSTAVYLALAASTLISASAQWASTTTFTFDGQALPTGLIISTDTIEDLADADSTAKFNHQFNASNVQISDGFLHLTVPGGQTESPIQCGEVSTEFEVMYASVCTYAILTGEAGICNGL</sequence>
</entry>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
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                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </dbReference>
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        <property type="interactions" value="783"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="362" mass="42259" checksum="7E82A0C670E953B6" modified="2011-10-19" version="1">MDNPSIMDKLQHKHLLTSPQNLTFSYYLSPNFAEKLDPSVPTLMFVHGYPDDAYMWEGAVPTFLDLPYPFLVLDLLGFGGSSKPVDASHYNYKAQADSIAQILDREKVPNNVIPIGHDWGSATSQRFYLYHKSRCVGLSLLSLAYQIPSAEKFDLDTQNKVTAERFGYPQWEYWNFFCRPDAPELMRQNMERFYEVNHGFFPSPNPEENGRDIWMREMFCTKHAMDEYVTQTGKWENRIVELKPYAKNPELLRRFKERMSRDGFEGPVNYYHSLKNNTMIEDEKALCESEDKKRIDVPLLYIGQTGDWVCRTDLMEDAKKQGLVSDCEEKVVDAGHWVLYEKPEEIASIIKEWLVKRFPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFU5</accession>
    <name>F9XFU5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_74015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851147.1">
        <property type="nucleotide sequence ID" value="XM_003851099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFU5"/>
    <dbReference type="FunCoup" id="F9XFU5">
        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFU5"/>
    <dbReference type="GeneID" id="13397887"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74015"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.360"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="F9XFU5"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="341"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP86123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="757" mass="83865" checksum="B8E1E1A4FD994951" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH05</accession>
    <name>F9XH05_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_95389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850252.1">
        <property type="nucleotide sequence ID" value="XM_003850204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH05"/>
    <dbReference type="GeneID" id="13394432"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95389"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.648"/>
    <dbReference type="eggNOG" id="ENOG502SEIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450716_0_0_1"/>
    <dbReference type="InParanoid" id="F9XH05"/>
    <dbReference type="OMA" id="FESHSEW"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="606" mass="69143" checksum="550F9A6326197976" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHL5</accession>
    <name>F9XHL5_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
            <ecNumber evidence="5">3.2.1.113</ecNumber>
            <ecNumber evidence="5">3.2.1.130</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MAN1.2</name>
        <name evidence="5" type="ORF">MYCGRDRAFT_74711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EC" id="3.2.1.113" evidence="5"/>
    <dbReference type="EC" id="3.2.1.130" evidence="5"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850025.1">
        <property type="nucleotide sequence ID" value="XM_003849977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHL5"/>
    <dbReference type="GeneID" id="13394901"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74711"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.346"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="InParanoid" id="F9XHL5"/>
    <dbReference type="OMA" id="YQDPIAC"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004569">
        <property type="term" value="F:glycoprotein endo-alpha-1,2-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391441" evidence="2">
        <location>
            <begin position="23"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="279"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="790" mass="86918" checksum="6BF1CF663BAE3C49" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHP7</accession>
    <name>F9XHP7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_46610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850379.1">
        <property type="nucleotide sequence ID" value="XM_003850331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHP7"/>
    <dbReference type="STRING" id="336722.F9XHP7"/>
    <dbReference type="GeneID" id="13394882"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46610"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070605_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHP7"/>
    <dbReference type="OMA" id="EHRTIVH"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="231" mass="26712" checksum="90DACA5A6E9918C6" modified="2011-10-19" version="1">MRAIQSKNGDSQPEQQIRQKPRVVQPPANKHKKRYQCDVADCGKAFYQKTHLEIHTRAHTGIKPFLCKEPSCGQRFSQLGNLKTHERRHTGERPYHCDICGKTFAQHGNVRAHKIVHTAAKPFTCRLDNCNKQFTQLGNLKSHQNKFHVETIRRLKQRFETIQEGDVVDSWEKEMWEYFVNLYKNCNKGIKGRGKDRRISTTSRRDSITSGGSSSGSGFDMDGMSLQQRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHV8</accession>
    <name>F9XHV8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_47065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849884.1">
        <property type="nucleotide sequence ID" value="XM_003849836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHV8"/>
    <dbReference type="FunCoup" id="F9XHV8">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHV8"/>
    <dbReference type="GeneID" id="13395186"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47065"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.44"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="F9XHV8"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="220" mass="24795" checksum="A6E3C072A3C97C72" modified="2011-10-19" version="1">MSSGTSRGHLIVFEGLDRSGKSTQCARLVDHLRSQGKEVFHQRFPDRTTVIGQMINSYLSGTSSQEDHAIHLLFSANRWEASESIRQHIERGTTVVVDRYYYSGCVYSAAKQNPAMDLAWCRHPEIGLPRPDLCLFLDIAAEEAAKRGGFGTERYEKQELQDRVRDLFAELQTHPDEAEDIVVIDAGQSVETVEQSIHDAVGRRLDGEHAVGPVRYIQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHW0</accession>
    <name>F9XHW0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850369.1">
        <property type="nucleotide sequence ID" value="XM_003850321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHW0"/>
    <dbReference type="GeneID" id="13394247"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45705"/>
    <dbReference type="eggNOG" id="ENOG502S7T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093936_1_2_1"/>
    <dbReference type="InParanoid" id="F9XHW0"/>
    <dbReference type="OMA" id="DPEPWQK"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="168" mass="19207" checksum="BA384EE3128F8D48" modified="2011-10-19" version="1">MSTPGETSRTAFFYGTLMAPEVLHRVCHGSMSPTNPIYTTHQLKIKPAILHNHRRHRVKTADYPAIIPQSGSSVRGNIVTGLTDQDIFRLDVFEGDEYERVKVRATLLTTVGDEQGEGNVEGEEVEVETYVWRAGEQELEDEEWDFKEFQREKMRFWVGREGEGEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHX4</accession>
    <name>F9XHX4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_95203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850051.1">
        <property type="nucleotide sequence ID" value="XM_003850003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHX4"/>
    <dbReference type="GeneID" id="13394252"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_95203"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.415"/>
    <dbReference type="HOGENOM" id="CLU_1788357_0_0_1"/>
    <dbReference type="InParanoid" id="F9XHX4"/>
    <dbReference type="OrthoDB" id="10290136at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP85027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="145" mass="15069" checksum="493F07528F91DFBD" modified="2011-10-19" version="1">MSRTRPISFATGGVHATDAPVTLFYREPDDRNYHACGLYHTPGLHAVITVALDAMCDTPGRTILRTDDGSGAAVSVEGLVHILATETKLGGGHLDSVYVTVYSSDPFAVAGPAAAALASPAGQAQRVAAGERISFNEKHGCCAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9XHX6</accession>
    <name>F9XHX6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HTA2401</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_46643</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850053.1">
        <property type="nucleotide sequence ID" value="XM_003850005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XHX6"/>
    <dbReference type="FunCoup" id="F9XHX6">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XHX6"/>
    <dbReference type="GeneID" id="13394254"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46643"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="InParanoid" id="F9XHX6"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="132" mass="14165" checksum="470F6B95DAD2960D" modified="2011-10-19" version="1" fragment="single">TGGKTGGKAGDSSGKSQKSHSAKAGLQFPCGRVKRFLKSQTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIKATIAFGGVLPHINRALLLKVEQKKTKKIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIE2</accession>
    <name>F9XIE2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MYCGRDRAFT_74458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850494.1">
        <property type="nucleotide sequence ID" value="XM_003850446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIE2"/>
    <dbReference type="FunCoup" id="F9XIE2">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIE2"/>
    <dbReference type="GeneID" id="13402715"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74458"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.125"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="InParanoid" id="F9XIE2"/>
    <dbReference type="OMA" id="EAYWSTP"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000228">
        <property type="entry name" value="Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="43"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="749"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="700"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="794" mass="89524" checksum="86EFE8848ABBC040" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIV3</accession>
    <name>F9XIV3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_47462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849682.1">
        <property type="nucleotide sequence ID" value="XM_003849634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIV3"/>
    <dbReference type="STRING" id="336722.F9XIV3"/>
    <dbReference type="GeneID" id="13402479"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47462"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="F9XIV3"/>
    <dbReference type="OMA" id="LMERSCK"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="236" mass="25202" checksum="13FBC3DF2FCADD3D" modified="2011-10-19" version="1" fragment="single">SIAAGSHGGVAVDAIPKFESYATQRQWTLEHLAGACRVFGREGYAKGIAGHISVRDPEFHDRFWINPLAVHFSMMTISDLICLDMQGNVVGGNRVSTANAAGVAIHTACHLARSDAHAVCHAHSLYGKAWAAFGRNLDMISQDVCYFYKAHSVYDNNGGIAFAADEGSNIAQALGKNKAAILVNHGLITVGQTVDEAAYLYTLLEKSCRIQLMVEATGLPKSIAGRRGGEYISHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ18</accession>
    <name>F9XJ18_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_21909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849297.1">
        <property type="nucleotide sequence ID" value="XM_003849249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ18"/>
    <dbReference type="GeneID" id="13402617"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_21909"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="F9XJ18"/>
    <dbReference type="OMA" id="TWTMDNR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="436" mass="48921" checksum="D36CB0562A5B89DB" modified="2011-10-19" version="1" fragment="single">YTPDEEIRVRRKLDIRLVLFVAMLYMVSFLDRTNIGNANVAGLSTSLDLSTSQFEWLLRAFYVSYVLFEWMTICYTLFPPHIYIASCVFFWGLLACLQAFATNFAFLLVLRVLLGIAEAAFVGMPIYLSFFFRRDELALRTGMFIAAAPLASSFSGFLAYAIMRFGDILPISNWRVLFFLEGAPALLVAIVAWYWLPDRPSTARWLTARERKVATLRMRSETTSSEPTKFATHSIEWSTLLSPLLTPLSYLPALMFFACNVAFSSMPVFMPLILTDMGFPPLTSQALSAPPYLLAFLAILLTAYLSDRHHTRTVPMVFHALLAMSGYSLLALAQRFRLGVWTRYACVFPICAGFFSCVTVVITWTVNNQRTAAEKGTGVGILQFTGQLGPFVGTGLYPKEDGPYFERGMVVCAVCMLCVAGLAGGYCWMLKKENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJQ2</accession>
    <name>F9XJQ2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MYCGRDRAFT_110850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849494.1">
        <property type="nucleotide sequence ID" value="XM_003849446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJQ2"/>
    <dbReference type="FunCoup" id="F9XJQ2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XJQ2"/>
    <dbReference type="GeneID" id="13402418"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110850"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.491"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="InParanoid" id="F9XJQ2"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44209" checksum="08660DD71CEFDB05" modified="2011-10-19" version="1">MAFGRSNSLSLNTGATNSMFSQQQQQSQANAAPAQATNPFASLGGQSSTQQQPISSMFGSSTTQNQAKPASNPFGNTSSNSVFGGLGGLGATAQQSSAINMFAKQPTTTQAPTAASSIFGNMNASQQAPSLLGAAQHNNLNQSQPFGRLSMGQANGAPSNTVGAVKVSLNDLRPTTRFEDCIDEVKSEMEAIDKMIQRQEQFAKELEAFLPAHEDNVNSIAPDVDFIRDKAEDVEQALSSDAQGVEAQRKNADKDVKDLERCQRIITNLSLPQGFQYNGMNSGGYGSMYGSQQRPAQRPSSNAGEDSNQYDTDLVNNYFVPKASELQGIMNMYASSLAEIESHMRVIEMSAVSQAQQLAQRRSGISGGQSTSNETVRELADTLRGFEESILGVAGVVGESRDGVNELVLGRIGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK28</accession>
    <name>F9XK28_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Pkc1b</name>
        <name evidence="24" type="ORF">MYCGRDRAFT_87605</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849507.1">
        <property type="nucleotide sequence ID" value="XM_003849459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK28"/>
    <dbReference type="FunCoup" id="F9XK28">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK28"/>
    <dbReference type="GeneID" id="13402408"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87605"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="InParanoid" id="F9XK28"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000769">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="235"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="464"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="842"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1102"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="598"/>
            <end position="735"/>
        </location>
    </feature>
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        <location>
            <begin position="755"/>
            <end position="815"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
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        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGP84483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128946" checksum="7555C0B5256D2ADA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XK68</accession>
    <name>F9XK68_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_47989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003849676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XK68"/>
    <dbReference type="FunCoup" id="F9XK68">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XK68"/>
    <dbReference type="GeneID" id="13399086"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47989"/>
    <dbReference type="eggNOG" id="KOG3473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130038_1_0_1"/>
    <dbReference type="InParanoid" id="F9XK68"/>
    <dbReference type="OMA" id="AMVSPII"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="122" mass="13481" checksum="AD78D4412914E54E" modified="2011-10-19" version="1">MATSEGASEYVTLVSSDEYSFVVRRSAACISGAIKRMLDPSNGFLESKTNTCRFDNINGLVLEKVCEYLYYNEKNRDAKNVPDMDLPTELCLEILMAADYLNGEECVALLYRGDANESGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKG4</accession>
    <name>F9XKG4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_75944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849543.1">
        <property type="nucleotide sequence ID" value="XM_003849495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKG4"/>
    <dbReference type="STRING" id="336722.F9XKG4"/>
    <dbReference type="GeneID" id="13402338"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_75944"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.605"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKG4"/>
    <dbReference type="OMA" id="HPNVVHM"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="235" mass="25116" checksum="82D69F3DF728BD02" modified="2011-10-19" version="1">MASQPEADTVAGAASSTNVGVETPRKEQPHTTAGATAAVDMNDPAIPLPDRTPAPTSTALDVPSSSPQLTRTQTEALGPATDAPIAHPTSAPTGPTLNISLMLTTGARHPYKVDERYLRNRKVEARTTGGDFDPRELSGYQLKELIWTDWRNEWDPRPASPSSIRLILMGRMIEDKGVLKDFPFKMDTTNVVHMTVKPADLIDDDDAAAKSTGKGGVLRAQDGEDSGAGCRCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
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        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849141.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKQ7"/>
    <dbReference type="STRING" id="336722.F9XKQ7"/>
    <dbReference type="GeneID" id="13398029"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111025"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.251"/>
    <dbReference type="eggNOG" id="ENOG502S59W">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031644_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKQ7"/>
    <dbReference type="OMA" id="EEAWVDD"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
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        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="2">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="518" mass="54313" checksum="5009968D2E1FD1A6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKU4</accession>
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            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKU4"/>
    <dbReference type="STRING" id="336722.F9XKU4"/>
    <dbReference type="GeneID" id="13398306"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48353"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
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    </dbReference>
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    <dbReference type="OMA" id="SHACWAM"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="302" mass="35078" checksum="A6F2E2D9353BFB3F" modified="2011-10-19" version="1">MEEVNFDEGKLDFDGLDPHLGQRLLDMHWKRQHHTYLVVYRPAFTRDMACAGPYFSKTLLNAIYFGAASLAGEFRKDPYDPQTAGWHFRERVRVLVRDAMEKSDITTIQALLLMTDSMFAMGDRQSIDTAWLYAGYAVCMIKKLGLHIDVTKRPNVMNLKEEDLEIRRRVFWSAFVIDKLHSMYQGQAPLLPHSQCDVPILFQDDYEELERWIPMTHEISRCPGYRTRSVSTFTHLCKLAVIMNEILERFYDPKGAEHEAEASDRAVTSIDKQLTDWARQLPKHLKGREPDWILPSHVMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKY5</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849227.1">
        <property type="nucleotide sequence ID" value="XM_003849179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKY5"/>
    <dbReference type="FunCoup" id="F9XKY5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XKY5"/>
    <dbReference type="GeneID" id="13398774"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_87670"/>
    <dbReference type="eggNOG" id="ENOG502RXMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKY5"/>
    <dbReference type="OMA" id="VIKSWNT"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="183"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="342" mass="36928" checksum="31BF91A92E2897F0" modified="2011-10-19" version="1">MANPSTQQRIDFVTLGMFILDDIHPSPTFPSKTPSLSIPGGAGTYSLLGARLLSPPPSNPIVAMIIDAGTDFPSSLLSTIRTWSTSSLIRQRDALTTRGWNGYSGNEVRAFKYLTPKLRLTAGDLTAELLASKTFHLICSPERCITEVNSILLRRANERVDERPLFIWEPVPDLCTAEELSRTLEANKVVDVVSPNHDELAAMFGTEHGSSVRVEMVEEHASNMVEHGIGRDGEGAIVVRCGAVGCFVLSRRVKKWLPAYHTDGSKVVDPTGGGNGFLGGLAVGLVRTGDVVDACRWGSVSASLCIEQVGVPVLEEAGNGKGEKWNGVDVLERLAEFRTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XKZ1</accession>
    <name>F9XKZ1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_49121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848761.1">
        <property type="nucleotide sequence ID" value="XM_003848713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XKZ1"/>
    <dbReference type="STRING" id="336722.F9XKZ1"/>
    <dbReference type="GeneID" id="13396595"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_49121"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.60"/>
    <dbReference type="eggNOG" id="ENOG502SIVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040697_0_0_1"/>
    <dbReference type="InParanoid" id="F9XKZ1"/>
    <dbReference type="OMA" id="IPLIHYH"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF4">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE APTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="377" mass="41271" checksum="3E88B7F7A8F8AA54" modified="2011-10-19" version="1">MSQPKIIIIGAGTAGLVLGRCLHHRGIPAILLEKAKNSPHRNNYGITLHAQTYRPLLKVLGLDETNFRRKVAVDSPVGGTGRISRHDSGEGDFRANRGRFEGLLAEGLDVRWESEVEDVKFGGPEGVTVGLKGGEKQTSKIVVGADGPHSRVREAVVKGVELKILPFATYNGKRRISPEEFEKTFAAAMGDGNTLEQRVGDALLQISISDRDEKEVSLSYTYSRPPRSNKGDDKLYRPERPKTGARELPEELFVELEGLAGKLEEPFRSIFDADAVRKDRLLNWLMRSLHLDVGQLREAAKGGVVLLGDAVHAEPILGGEGANVAIEDGMRLAALIAEDRETSLEKIYDARGRIWDKSVGESEARIAEMHGTVKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLC7</accession>
    <name>F9XLC7_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C2 heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_76134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848806.1">
        <property type="nucleotide sequence ID" value="XM_003848758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLC7"/>
    <dbReference type="STRING" id="336722.F9XLC7"/>
    <dbReference type="GeneID" id="13398733"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76134"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.149"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="InParanoid" id="F9XLC7"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="202" mass="22691" checksum="AD894E0196ED8C27" modified="2011-10-19" version="1">MAQAYKPGSTYFEDRKSFNDVSIGSDDSIPTTAFLEAAEALTGLFDVLGSAAFKPVKNDMAGNITKIRNRQLESPIESETLQDLVRNELKTKKHTATEGLLWLVRGLDFTAQSLRQNFARPDEELSQSFRDAYGQTLKKHHSFIIKPIFSAAMSATPYRRDFYAKLGDDQPKVNKELDAWLVGLEKNVAILNKFLASPEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLD9</accession>
    <name>F9XLD9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_96263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849106.1">
        <property type="nucleotide sequence ID" value="XM_003849058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLD9"/>
    <dbReference type="GeneID" id="13398145"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96263"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013895_0_1_1"/>
    <dbReference type="InParanoid" id="F9XLD9"/>
    <dbReference type="OMA" id="ISCIYWD"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="433"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="730" mass="79540" checksum="D1593FF8A5C7F0ED" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9XLY2</accession>
    <name>F9XLY2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_48553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001205">
        <property type="protein sequence ID" value="EGP83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848970.1">
        <property type="nucleotide sequence ID" value="XM_003848922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XLY2"/>
    <dbReference type="GeneID" id="13398434"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_48553"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_10.480"/>
    <dbReference type="eggNOG" id="ENOG502QVUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_2_1"/>
    <dbReference type="InParanoid" id="F9XLY2"/>
    <dbReference type="OMA" id="IFRMRID"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390846" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47355" checksum="841B4445895313E8" modified="2011-10-19" version="1">MLPQIAAAALLFADKALAQNVTFQDHTNTILRVDNGTYGPAIEEVHYYYKQWPIGIAVASDGRIFATYTRGDYEYTLGVCTNMTAEEPYPSADLNLPVSQLNTTYNGIDFGSSNSTGLISVQAIYITPQTSSRPETLWAIDTGRPTIHSSTGAASMPYAQPGGPKLIAISLSNNTIYRTYTFPPDVHYPDSYLNDLRFDFNPNLSSTSGAGIAYLVDSSNEGRPGFIMVDLASGKSWRRLTQDPSVLRDPNTVPTYFGHPFHFHTPGQPIIWPQEGLDGIQLSPDGSRLFYSPLVSTHLFSIPTSNLREQSQLSEIHARANVSDHGQRGGQANGFEGDDAGNIYQLMPEQNAIYYFDPNDGLTKGFVRDPRILWPDGASVAEDGYIYMNINQLPFQADWNDGIEGRVFPGAVLRAKLPEGKGKIRGLFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMF8</accession>
    <name>F9XMF8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_76625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848265.1">
        <property type="nucleotide sequence ID" value="XM_003848217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMF8"/>
    <dbReference type="FunCoup" id="F9XMF8">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XMF8"/>
    <dbReference type="GeneID" id="13396344"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_76625"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003155_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMF8"/>
    <dbReference type="OMA" id="MDIGDAY"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
    <sequence length="1198" mass="133782" checksum="1CA6F1B740D126FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 115943 / IPO323</strain>
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    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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            <end position="84"/>
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            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9716" checksum="F556011D19A015FE" modified="2011-10-19" version="1">MSASLASECNEVKERYDSCFLKWYSEKYVRGVATTDECEPLFKQYQVCLKATLKDRGIDTMLEEAREDNKDNDTEYMKPSPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMP2</accession>
    <name>F9XMP2_ZYMTI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003848642.1"/>
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    <dbReference type="AlphaFoldDB" id="F9XMP2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_11.110"/>
    <dbReference type="HOGENOM" id="CLU_1246212_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMP2"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="222" mass="24809" checksum="A54F9E9D49060C01" modified="2011-10-19" version="1">MAEVQLAIDLHDLVTSLRNLQPDDVAEGFSRITQRIRECLAAAQKLNRDAVGRQNTLIELSKEAHSRSQALQAELAKFGQPTKQALEDKIAALQAEIEEQAATRAREIQATTTRHASQLVVLHQAIDHSEVAQSRADAHSKRADARASLVEARLEAERKEFERQLSAERERRITAEKEVELLRAQQSASKDAAEAVSSTIVQEFVDRFGPKGTRRSGFHDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XMT6</accession>
    <name>F9XMT6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_96566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848661.1">
        <property type="nucleotide sequence ID" value="XM_003848613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XMT6"/>
    <dbReference type="GeneID" id="13396539"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_96566"/>
    <dbReference type="eggNOG" id="ENOG502T3J3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767702_0_0_1"/>
    <dbReference type="InParanoid" id="F9XMT6"/>
    <dbReference type="OrthoDB" id="3647705at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="361" mass="42175" checksum="4C1C6BA4A81C1E83" modified="2011-10-19" version="1">MPWQRPIFPTDSLKDHARVHINRWCDKQNPSVQSGQSRNYENTDEFMNWSLRFEIAALYTTRAWTTLTEQTLLDAVPNLKTWNGRDKHLLSLCDFVNSAVKKVHIDHLVGIAREREEKEELEQMTAEEEAMGPFAFLELPYDIRVRVYDFLVDEKYSEGSYYGRGDDKFIEVPWSDHYHADEFHERVVFDFIQVCHQLRLEFLPRWHRAVGLRFSMAPYHEPKETETWLQVFGPSRVPLTRSFEFEFGDDKVCIELRGAQSRTVSGDTRQLTDIGVALRDELKVSSPELYKGNWEGRRTRALREPGFEMHLQRFAETLVEKSANGSVKVTVGCITQVMEYLQQRTVPPQEEDSGEDDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XN38</accession>
    <name>F9XN38_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_26999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001206">
        <property type="protein sequence ID" value="EGP83582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848606.1">
        <property type="nucleotide sequence ID" value="XM_003848558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XN38"/>
    <dbReference type="STRING" id="336722.F9XN38"/>
    <dbReference type="GeneID" id="13396151"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_26999"/>
    <dbReference type="eggNOG" id="ENOG502SPKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1242756_0_0_1"/>
    <dbReference type="InParanoid" id="F9XN38"/>
    <dbReference type="OMA" id="QRRFRII"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="223" mass="26074" checksum="7AC495871E2AD005" modified="2011-10-19" version="1" fragment="single">QFNYLQWDSKFEDEKPYYLYTDPPPGEPNANFVTRPGEPEHVHDVRGREKEFNLDDHAFAFGHQVYPNLRDLNDATIQAEYMPSLEKHIRDLLKQEAVIFWFDWRIRSSDEAKSKYPEGTKISLGDRMTTLAPIKAVHVATDQTPAATLDRVHRHAPHMVDQLPDKRVRIINTVPDDKLIEVDVVRRTFLGESYYPLEGGGYRWHFMDHQTSDELLFMKMSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9XNZ6</accession>
    <name>F9XNZ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MYCGRDRAFT_50627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848106.1">
        <property type="nucleotide sequence ID" value="XM_003848058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XNZ6"/>
    <dbReference type="FunCoup" id="F9XNZ6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XNZ6"/>
    <dbReference type="GeneID" id="13396067"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_50627"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.307"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="InParanoid" id="F9XNZ6"/>
    <dbReference type="OMA" id="YWCTSYA"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGP83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="544" mass="59316" checksum="0DF59251FA1D50CD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPC6</accession>
    <name>F9XPC6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MVD1</name>
        <name evidence="18" type="ORF">MYCGRDRAFT_77157</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003848249.1">
        <property type="nucleotide sequence ID" value="XM_003848201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPC6"/>
    <dbReference type="FunCoup" id="F9XPC6">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XPC6"/>
    <dbReference type="GeneID" id="13401915"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_77157"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_12.8"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="InParanoid" id="F9XPC6"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="201"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="391" mass="41901" checksum="7A9C37F0C91D5149" modified="2011-10-19" version="1">MASSSSADDITRASTFAPVNIAVIKYWGKRDTKLNLPTNASLSVTLSQDDLRTHTTASCSPSFTSDSLTLNSQPQDISGARTQACLRELRSLRADLESSDPSLPKLSTQHLKIVSENNFPTAAGLASSAAGFAALVRAIANLYALPSSPTDLSRIARQGSGSACRSLMGGYVAWQKGEQADGSDSFAYEVSPASHWPDMRAIILVASAEKKDVSSTAGMQQTVATSALFAHRAEEVVPKRMKAMEKAIHNRDFEAFAVLSMKDSNNFHATCLDTQPPIFYMNDTSRAAVRMVEAINALHPEGKTYAAYTFDAGPNAVVYYLAQDEDMVAGVFKGLLGEKTGWDSPRGKKIQVKEGALAGTEVAGEKLKEGISRVILTSVGDGPRKTEEHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPI4</accession>
    <name>F9XPI4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_18839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001207">
        <property type="protein sequence ID" value="EGP82846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847870.1">
        <property type="nucleotide sequence ID" value="XM_003847822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPI4"/>
    <dbReference type="STRING" id="336722.F9XPI4"/>
    <dbReference type="GeneID" id="13401806"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_18839"/>
    <dbReference type="eggNOG" id="ENOG502S9TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093235_1_0_1"/>
    <dbReference type="InParanoid" id="F9XPI4"/>
    <dbReference type="OMA" id="QFYNEGY"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="144" mass="15910" checksum="5B42FE1C52037E77" modified="2011-10-19" version="1" fragment="single">FADLLNLEDQYHNEGYLLGVADGSKSGRIEGRVFGLQKGFEKFVEMGRLNGKAAVWEARLPSESKATTDSISTQEDVEESNVRVEPLKNGGDRLRKHVLRLAALSDPDDLSTDNDEDSVSEFDDRLKDAKAKATLIARLVGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPQ8</accession>
    <name>F9XPQ8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_97287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847526.1">
        <property type="nucleotide sequence ID" value="XM_003847478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPQ8"/>
    <dbReference type="GeneID" id="13400825"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97287"/>
    <dbReference type="HOGENOM" id="CLU_1134322_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPQ8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP82502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="245" mass="24651" checksum="A86C46B8515945D4" modified="2011-10-19" version="1">MLGTSLLSGSRNDHGSPCAKVVSTFPLRRRVIASPSLSRIWHLNAGSTSAPMVKTAEFESGLGGEVEFIVQLHADGGVCSSGRRSGSGDFDKGRVAGDGADILLAVNEGPWSGGAAIGEGGVLHAIADQEDRKPRGGTDELTAEGFVDHIGSETEVDGVKGAGRASAGLGVGEGGLVEGRAGAEFDALVGEADADGGVGCCLAAVDGWGGEGAGDAQGGEKEGGVLHVDGEDFADYCWVNIELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XPZ6</accession>
    <name>F9XPZ6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_25958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847768.1">
        <property type="nucleotide sequence ID" value="XM_003847720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XPZ6"/>
    <dbReference type="STRING" id="336722.F9XPZ6"/>
    <dbReference type="GeneID" id="13401192"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_25958"/>
    <dbReference type="eggNOG" id="ENOG502RKQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="InParanoid" id="F9XPZ6"/>
    <dbReference type="OMA" id="HYWEPAW"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP82744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="332" mass="36536" checksum="E09D9E5DC24F7C34" modified="2011-10-19" version="1" fragment="single">YAGHDLSSLKIMTDGGAIYKDTARGNATRPAEDILGDGGMNTVRLRLWVNPVVPYDGGYYESYDLQNVKAAAKQYHDKGFKIYLDFHFSDYWADPGKQAIPAAWPQEVGPLADTLRDYVSSTLEAFHNDGVDLAIVSLGNELEHGMLWPTGFVNITAEPIDFTNLSVLYKAAREGVNDACAAGVPEPSVMIHLPNGWDDELQLTWYDHLTASGVVQPSDWDLFGVSMYDFYGGNATLLNLETTLNAMALKYHKPILVVETDWAEECSIPVVPELMADTGISFSAQGQLDWVGAIVKIVKELPYGLGQGIFYWEPAWLNSTSLGGPCQDLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XQ03</accession>
    <name>F9XQ03_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_51270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001208">
        <property type="protein sequence ID" value="EGP82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847765.1">
        <property type="nucleotide sequence ID" value="XM_003847717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQ03"/>
    <dbReference type="FunCoup" id="F9XQ03">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQ03"/>
    <dbReference type="GeneID" id="13400796"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
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                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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                <person name="Antoniw J."/>
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                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Van der Lee T.A.J."/>
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                <person name="Antoniw J."/>
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                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
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                <person name="Nap J.P.H."/>
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                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001209">
        <property type="protein sequence ID" value="EGP82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847424.1">
        <property type="nucleotide sequence ID" value="XM_003847376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XQR2"/>
    <dbReference type="FunCoup" id="F9XQR2">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XQR2"/>
    <dbReference type="GeneID" id="13400376"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_51638"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_14.77"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="F9XQR2"/>
    <dbReference type="OMA" id="HEWYENQ"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP82400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="562" mass="62258" checksum="35A30FE70C523FE9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR41</accession>
    <name>F9XR41_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847219.1">
        <property type="nucleotide sequence ID" value="XM_003847171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR41"/>
    <dbReference type="GeneID" id="13399872"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97703"/>
    <dbReference type="HOGENOM" id="CLU_1571843_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR41"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="170" mass="19758" checksum="7400116A7788E573" modified="2011-10-19" version="1">MPADDLATQRALFSRYHALLDTETLLTAQHNETTRRTDRLAQRKARLLSTREDRQEYVSDDVLVEIARVLDIEAEESLLKVRDRTLREMLGEVRQEVARFCNEKRRGYWRLQCQDSEVGWSARDRSMALGLLVVLLYGLAWANLIEEEIGSSLVAFSLIAMFQSVWARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>F9XR83</accession>
    <name>F9XR83_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001211">
        <property type="protein sequence ID" value="EGP82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847237.1">
        <property type="nucleotide sequence ID" value="XM_003847189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XR83"/>
    <dbReference type="GeneID" id="13399933"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97742"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_16.56"/>
    <dbReference type="HOGENOM" id="CLU_1817324_0_0_1"/>
    <dbReference type="InParanoid" id="F9XR83"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="142" mass="15292" checksum="4B74BF90E597D103" modified="2011-10-19" version="1">MSAACHKDRLRVTPPRSRPCLLHHCRSRKDISFAAATNPVPRLLNATCTVHSSNPRASSFIDASHKLELPTAVDGSWSSTHEEESPGCMSREVGAQGSERLKPDDALMVPLHDIVTLVLEVLGDIGTRGPICGTDEPAAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRE8</accession>
    <name>F9XRE8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001212">
        <property type="protein sequence ID" value="EGP82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847204.1">
        <property type="nucleotide sequence ID" value="XM_003847156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRE8"/>
    <dbReference type="GeneID" id="13399708"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97800"/>
    <dbReference type="HOGENOM" id="CLU_1929243_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRE8"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="131" mass="14614" checksum="9F7F0EC64C5CCDBE" modified="2011-10-19" version="1">MDDFDEWQIVEKLRGEGGSGARDCFGGEGGSGARYGEERRVHYEASLREARSGPHKKEKNTITPTLVKRVVICVCVMLFLAGCSNYGAVKHEEPVFYRSASLAGRVPTMTNYSDMKSLWSLIDRDLLGKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XRU9</accession>
    <name>F9XRU9_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_97941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001214">
        <property type="protein sequence ID" value="EGP82034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003847058.1">
        <property type="nucleotide sequence ID" value="XM_003847010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XRU9"/>
    <dbReference type="GeneID" id="13399248"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_97941"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_19.29"/>
    <dbReference type="HOGENOM" id="CLU_639692_0_0_1"/>
    <dbReference type="InParanoid" id="F9XRU9"/>
    <dbReference type="OrthoDB" id="10312635at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP82034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="429" mass="49424" checksum="7448C10F628A8581" modified="2011-10-19" version="1">MENHSRFKNRQQCAKWQEDLRCLEERLEIEQAQLHEDRQKHDSDQSRLTARIHKSQRREEELKVWEQNLEAWTVEREKQQEGLRQQKVAISEEKDLLGHESEFLRQQDSKQQQREEDLYRRAADVEAMDRAARDNAERVNEIRRDVERRMIELQELEVELDGRAVACERREAKVERDEREARFRGRGGGSSITEEYEEDEEFQGRGKGRRSSVGCCWPPSSSSSASREAPASDDEAGLTTAHRRDVLGTEKEEEHGEYQEAMEHPPYPVDDAFHIASKSPGRLGEVSDSLHRPLTPLPETDICEIDASTDDDPTLFMTAGQLLPILHRVLLPQRQPRRDGVLSAMRHCAEQHSQLRPVGIDWPALPNTLPDMPAIRAEVFDVLHVDVETDEAFQTWQDELIRADQEDAVTEGRLLALFEQTCKAGLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9XS51</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001215">
        <property type="protein sequence ID" value="EGP81938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003846914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XS51"/>
    <dbReference type="GeneID" id="13396718"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_111799"/>
    <dbReference type="HOGENOM" id="CLU_934500_0_0_1"/>
    <dbReference type="InParanoid" id="F9XS51"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="298" mass="33211" checksum="D69F5965FFDFA95B" modified="2011-10-19" version="1">MHLAGSPVTRTRSKRVGRISLFRKRQNVPGMDAEKGSKVGSDRKVRDSMIVREERLGRDGDVDDCSDAEDSVGEDCGGEEDDIGGDINGDINDDDDINVIEGSRQTQSEVAQLHRNQLDMVTRFEATIQQRCDEGKADLQTWLEQQHALAITELCVEQQHLRASMQHLQDEHTRLQSVQAAELSTLRAEQDGLSDFVCRLRADATLHLDPAPNPDSSNTVPRLGLEEKQQLEVKTELEEPEEDASTTVLLGDILTTGLGRAMELVVQIGQRQHSVEEEKGSVMKETRCRTTRFDCGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XSB2</accession>
    <name>F9XSB2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_106715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001216">
        <property type="protein sequence ID" value="EGP81837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003846813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XSB2"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106715"/>
    <dbReference type="HOGENOM" id="CLU_1870162_0_0_1"/>
    <dbReference type="InParanoid" id="F9XSB2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP81837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="137" mass="15459" checksum="77F367C0EE56FD0B" modified="2011-10-19" version="1" fragment="single">MFPSTCVRHRSSNTRTRASRPILTLLTSRTLNFRPTRRATATKRGESVSTAPARHDWRSMSSSHDDSRAMYRNRHHLRACSKPTHADDVPELNVSLSRIPTPAHYIPDLLSRSTSPADQSSSVQSGGSEQRSFSWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A9Y5H7</accession>
    <name>A9Y5H7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="4 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nad3</name>
    </gene>
    <organism>
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18"/>
    <reference evidence="18" key="1">
        <citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="628" last="637">
            <title>Intraspecific comparison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus Mycosphaerella graminicola.</title>
            <authorList>
                <person name="Torriani S.F.F."/>
                <person name="Goodwin S.B."/>
                <person name="Kema G.H.J."/>
                <person name="Pangilinan J.L."/>
                <person name="McDonald B.A."/>
            </authorList>
            <dbReference type="PubMed" id="18226935"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 17"/>
    <dbReference type="EMBL" id="EU090238">
        <property type="protein sequence ID" value="ABU40264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001648748.1">
        <property type="nucleotide sequence ID" value="NC_010222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Y5H7"/>
    <dbReference type="STRING" id="336722.A9Y5H7"/>
    <dbReference type="GeneID" id="5846266"/>
    <dbReference type="InParanoid" id="A9Y5H7"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1610:FF:000009">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 17 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="13 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABU40264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="119" mass="13521" checksum="DB47305BED19510E" modified="2008-02-05" version="1">MTFFLIFVPILAIVLLTLNLILAPHNPYEEKDSAFECGFHSFLGQNRSEFSISFFIFALLFLLFDLEILLVYPFVVSAYVNGIFGLIVMLIFFLVLTLGFAFELGKNALSIESRQTHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9WWY1</accession>
    <name>F9WWY1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_67069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857064.1">
        <property type="nucleotide sequence ID" value="XM_003857016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WWY1"/>
    <dbReference type="STRING" id="336722.F9WWY1"/>
    <dbReference type="GeneID" id="13395400"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67069"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051534_0_0_1"/>
    <dbReference type="InParanoid" id="F9WWY1"/>
    <dbReference type="OMA" id="KSAPRYW"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP92040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="272" mass="30031" checksum="7157028715D5C82F" modified="2011-10-19" version="1">MSEYWKSTPSYWCKFCSQYVRDSPLERKNHEASGKHQNNIQRNLRELHKGREREERDKQRAKDEVARLNGLVGDKSGSNKSTIQPPSRPVQAQPAATPSSLAAQRKAHAEQLAAMGIDLPEELKKEVTGVGNYHVVAERVVGPAEGGASEDEGESISRRAYKRKAEEVEGARDEEAAPKRQAWGSNIKSYPGKTEAVDDGTDLDALLNGVAKKKEPEAKKEKTEEGGDVKQEEEIETTKPLSEIPDVSSIKPEVDAGSSAPTIMFKKRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WXY7</accession>
    <name>F9WXY7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_107156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
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        <location>
            <begin position="217"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP92384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="329" mass="36869" checksum="03455DB02CB5CB03" modified="2011-10-19" version="1">MQSIRQIERLNQTELEKVIPSNASWHTDYRDTAYLYIGGLPFELSEGDILTIFSQYGNPVHINLVRDKETGKSRGFCFLKYEDQRSCDLAVDNLSGAGVMGKVLSVDHTRYKKKEGEVEGIGDEEADEVDDTDKEGDDRRKRRRTASISESEEERPLIKEEIELAKLIKNIEEDDPMKEFLVKEKRAEVEEALKAVVKHKSKEKDRSRKHRHHHRSRKEDGGKESRDKSRDRHRSRRDKERGEILCFVGASTSAIAAAAFESVLAEAASIDGAVDAAVCSKTFADPTASQAGREEDGQDDKKVDTHDCDLPSGAEMFLAGDASVISGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">DUF2241 domain-containing protein</fullName>
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        <name evidence="2" type="ORF">MYCGRDRAFT_32685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856601.1"/>
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    <dbReference type="AlphaFoldDB" id="F9WYH4"/>
    <dbReference type="STRING" id="336722.F9WYH4"/>
    <dbReference type="GeneID" id="13398818"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_32685"/>
    <dbReference type="eggNOG" id="ENOG502S8Y4">
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    </dbReference>
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    <dbReference type="OrthoDB" id="10064407at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="VC0802-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199:SF1">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
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    </dbReference>
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        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2241" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="14177" checksum="4DD5E7341D202D7C" modified="2011-10-19" version="1">MNPTLDAEEYVFAELSLEAPHFAEFLGAVSKDVKMLFREKEAWTIILPKSAADREGLYYTFPCRQVTLNVHSSLEAVGFLAAITTRLAEKVNVGVNAISGYYHDHLFVPVGKEDAVMEELLSLAAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F9WYN2</accession>
    <name>F9WYN2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_31905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003856902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WYN2"/>
    <dbReference type="FunCoup" id="F9WYN2">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WYN2"/>
    <dbReference type="GeneID" id="13398216"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31905"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.1898"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="InParanoid" id="F9WYN2"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="99" mass="11005" checksum="8A9F10D370064C0E" modified="2011-10-19" version="1">MSENNGSPAGEKPEDQQPVSEHLNIKVTDSSNEVFFKIKRSTQLKKLMDAFCERQGKSPQSVRFLFDGQRVNSSDTPDTLEMADGDCLEVHQEQIGGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ43</accession>
    <name>F9WZ43_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RuvB-like helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RUVBL2402</name>
        <name evidence="16" type="ORF">MYCGRDRAFT_98372</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857503.1">
        <property type="nucleotide sequence ID" value="XM_003857455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ43"/>
    <dbReference type="FunCoup" id="F9WZ43">
        <property type="interactions" value="1387"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ43"/>
    <dbReference type="GeneID" id="13394481"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98372"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="F9WZ43"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="78"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGP92479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="476" mass="51583" checksum="8409EBE84B655DFA" modified="2011-10-19" version="1">MATNGAAAPPAAPTTVKIQEVQQTNSRENRTAAHSHIKGLGLRSDGYADTNAQGFIGQTAAREACGVVVDLIRAKKMAGKAILLAGGPGTGKTALALAVSQELGTKVPFCPMTGSEVYSAEVKKTEALMENFRRAIGLRVQERKEVYEGEVVELTPEESENPLGAYGRTISHLMITLRSSKGTKKLRLDPSIYEAIQKERVRLGDVIYIEANTGAVKRVGRSDAFSTEFDLEAEEYVPVPKGDVHKKKDIVQDVTLHDLDVANARPQGGQDVMSMMGQLMKPRKTEITEKLRGEINKVVNKYIDQGIAELVPGVLFIDEVHMLDIECFTYLNRALESTISPIVILASNRGQTTIRGTGSVQSNDPGLISAHGIPPDLLARLLIVPTHAYTATEIRTIIQTRAKLDPEALDELTTQGETVSLRYALQLLVPASILARARGSEGNVISGDDVAEAKSLFWDAGRSANQLKERASEYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ51</accession>
    <name>F9WZ51_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">MYCGRDRAFT_31648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857392.1">
        <property type="nucleotide sequence ID" value="XM_003857344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ51"/>
    <dbReference type="FunCoup" id="F9WZ51">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9WZ51"/>
    <dbReference type="GeneID" id="13394670"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_31648"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZ51"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:rDNA heterochromatin formation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP92368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="256" mass="28838" checksum="279AEA9553709352" modified="2011-10-19" version="1">MSDSEPEETWDDLFQEPTDYYRPDKEPTQVEHKTLNGDVLKLNLVGQNPLWGHLLWNAGRTIADYLELNKDTLISNKTVLELGAGAGLPSIICATNGAKQVVVTDYPDADLIENLEKNCKLVPQPRNIHAAGYLWGAEAAKVKGFLPEAESEAGFDLLILADVLFNHSEHARLLLSIQQTLKKTSDAQALVFFTPYRPWLLEKDLAFFDLAREGGFTVEKILEKVMEKVMFEEDRGDELLRRTVFGYTLKWPGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZ88</accession>
    <name>F9WZ88_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_17425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856284.1">
        <property type="nucleotide sequence ID" value="XM_003856236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZ88"/>
    <dbReference type="STRING" id="336722.F9WZ88"/>
    <dbReference type="GeneID" id="13402945"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17425"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_9_2_1"/>
    <dbReference type="InParanoid" id="F9WZ88"/>
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    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP91260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="186" mass="19784" checksum="ADF26B8F98FCB2FA" modified="2011-10-19" version="1" fragment="single">PAQPKLNPPKLKTMGGVGSGGAYNHVPQPLLHSMRESFEVLDSSNSGTVTSAAVSDMLSQLGLDNTPAALRDFFPPNGPGQLNLARYLDILSAPLADLSQPEELRAAFEAFDVDDSGQIDVSVLRDALLHTTPQPGEDMIRLSEKEVDGILGEFAGRRAFGSKGLNAAKGKGDVFKYRDFMANVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZA1</accession>
    <name>F9WZA1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_66114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856294.1">
        <property type="nucleotide sequence ID" value="XM_003856246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZA1"/>
    <dbReference type="GeneID" id="13394775"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_66114"/>
    <dbReference type="eggNOG" id="ENOG502SI37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013869_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZA1"/>
    <dbReference type="OMA" id="TYFASYV"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP91270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="714" mass="79178" checksum="3F3394A05D0AEE6B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZH3</accession>
    <name>F9WZH3_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_88640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855860.1">
        <property type="nucleotide sequence ID" value="XM_003855812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZH3"/>
    <dbReference type="GeneID" id="13403782"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_88640"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.66"/>
    <dbReference type="HOGENOM" id="CLU_1435497_0_0_1"/>
    <dbReference type="InParanoid" id="F9WZH3"/>
    <dbReference type="OMA" id="AVYLDCN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20444" checksum="9FC9C51571F18925" modified="2011-10-19" version="1">MATNTTIDIIGHATLRFASGTEILFEYEFKNPALLFLACTVEQSLAAVARKNAPPNNRQLAITGDAIARAVLSTKWIEGGGSTLQWESIHGRGIATNRYLAHMAEIKGVMENLAMLNGCSAAGIPIHHTIKATMVEAIFGAVWLDSKDLGVVEEVMRLLGVFWPVDAEVERMLLVFLGELRQLGVLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZI8</accession>
    <name>F9WZI8_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="6">Glutaminase GtaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_106753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855865.1">
        <property type="nucleotide sequence ID" value="XM_003855817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9WZI8"/>
    <dbReference type="STRING" id="336722.F9WZI8"/>
    <dbReference type="GeneID" id="13403344"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_106753"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="InParanoid" id="F9WZI8"/>
    <dbReference type="OMA" id="GWEIWTA"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395438" description="Glutaminase GtaA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="106"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="345"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="87195" checksum="9F01C4A135BA320D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9WZX8</accession>
    <name>F9WZX8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_32817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857495.1">
        <property type="nucleotide sequence ID" value="XM_003857447.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="F9WZX8">
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        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
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        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tsr1_G-like"/>
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        <property type="entry name" value="DUF663"/>
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    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
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            <end position="246"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EGP92471.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="823" mass="92386" checksum="C433ACD1D4EF9849" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9X065</accession>
    <name>F9X065_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">MYCGRDRAFT_66188</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chap_CCT_delta"/>
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        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
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        <property type="entry name" value="GROEL-like_equatorial_sf"/>
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    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
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        <property type="entry name" value="TCP-1_chaperonin"/>
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        <property type="entry name" value="thermosome_alpha"/>
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        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TCOMPLEXTCP1"/>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
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        <property type="entry name" value="TCP1_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP91291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="541" mass="57780" checksum="960971771B8A8ADB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0C3</accession>
    <name>F9X0C3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_83947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856451.1">
        <property type="nucleotide sequence ID" value="XM_003856403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0C3"/>
    <dbReference type="GeneID" id="13395084"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_83947"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_3_1"/>
    <dbReference type="InParanoid" id="F9X0C3"/>
    <dbReference type="OMA" id="QWNEDEG"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF2">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP91427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59867" checksum="0026A9C0A6392E19" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0V8</accession>
    <name>F9X0V8_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LUC7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_98404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP92439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857463.1">
        <property type="nucleotide sequence ID" value="XM_003857415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0V8"/>
    <dbReference type="FunCoup" id="F9X0V8">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X0V8"/>
    <dbReference type="GeneID" id="13403034"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_98404"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.769"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_1_0_1"/>
    <dbReference type="InParanoid" id="F9X0V8"/>
    <dbReference type="OMA" id="CPYDLFQ"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP92439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33467" checksum="A5BF0E8B2C8A2047" modified="2011-10-19" version="1">MAAEQRKLLEQLMGEQLLAAPGTLRQPALAITDPKVCRSYLCGGCPHDLFTNTKQDLGSCDRMHLPNLREEYLAATDDQRRDWGFEFDYQRDIGKYVSECDRRIEGAQRRLEKTPEEIRQTNALLKQISDLGRTIEAGLIEVEIMCELGAVNLGVQEFHNLKLKKVQKDERERELKALSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHLGYAQMRKEYDRLAKELKGRPPPRRDEPVEERGGYDDGGYGGGYGGRNGGGYGGGRGGGGGGGYGRRGGDGGGFGGGGGRGRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9X0Y1</accession>
    <name>F9X0Y1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_107106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001196">
        <property type="protein sequence ID" value="EGP91173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003856197.1">
        <property type="nucleotide sequence ID" value="XM_003856149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X0Y1"/>
    <dbReference type="STRING" id="336722.F9X0Y1"/>
    <dbReference type="GeneID" id="13403021"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107106"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_1.794"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379929_0_0_1"/>
    <dbReference type="InParanoid" id="F9X0Y1"/>
    <dbReference type="OMA" id="STTINRH"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
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            <end position="272"/>
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            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="84120" checksum="32DD5F7AB2732F11" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001196">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X1N4"/>
    <dbReference type="STRING" id="336722.F9X1N4"/>
    <dbReference type="GeneID" id="13398418"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_67639"/>
    <dbReference type="eggNOG" id="ENOG502S4N0">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030892_0_0_1"/>
    <dbReference type="InParanoid" id="F9X1N4"/>
    <dbReference type="OMA" id="TNIYRWS"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="385" mass="42659" checksum="A22DE41E03623899" modified="2011-10-19" version="1">MDLEVARQPVPEPSDGEMYLLKIPNFMSIEPQAWQTTAFQPPTADHHSKEASATFSAYNTAMSTVRWRHSPSNPAELQSNARINRWSDGSITLQLASDPTTQYEMDGNALAPPQINPPKPTPFSVAANAKRGASKDAFTYLVVPVESAESLRITHKITASLNVKQSGTVEDDAIAQLQAALSQAANKTKVGGASGVLEATDVDPELQRKQAELAEKQAMRDRKKRENAQERDRMRSDRTLGRAGVYSGRSGGGLNVGMLEDDEMDGGRGRSQGNKARAKPRRRRNSEYSDDEDFGNKRFSKEDSYDQEDDFVAPSDEEEVVEDDDDEDDGIMEERTEKAPKRDRPRPAAAAETGDDEDAEGEEDDDLPQARTKRRRVVDDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855719.1">
        <property type="nucleotide sequence ID" value="XM_003855671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X223"/>
    <dbReference type="STRING" id="336722.F9X223"/>
    <dbReference type="GeneID" id="13403659"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_107904"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_2.242"/>
    <dbReference type="eggNOG" id="ENOG502RPAJ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1571847_0_0_1"/>
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    <dbReference type="OMA" id="TNDWANN"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP90695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="170" mass="17968" checksum="EEF4741D429050E0" modified="2011-10-19" version="1">MHFTQITALVALLSASAMGVALPEDGGDAPKGQAPHTGSDTGHNNCGPSTINPATGNGPKPEYNDCHTLAQNIGRADKSYRIRGDKGPRQIGYFGTCQFTATVQRPQQAWLGCNDVEDLIGSSLKQWDQFPNGCGGTILTGNGGEVPCDNVKDGGPVTVYWSLSYYHQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3D2</accession>
    <name>F9X3D2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
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                <person name="Csukai M."/>
                <person name="Dehal P."/>
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                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003855714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3D2"/>
    <dbReference type="GeneID" id="13403702"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_35980"/>
    <dbReference type="eggNOG" id="ENOG502SIJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_2_1_1"/>
    <dbReference type="InParanoid" id="F9X3D2"/>
    <dbReference type="OMA" id="DTEQCAK"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP90738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47921" checksum="88EDDCAABFB4B781" modified="2011-10-19" version="1">MLLGSPDALGQFGPWYGDTQNNSPTSTSAIEVAQRNTHDQALSPHQSHPKKNSSLLGTFYRLATPTASARFSEEHLVQHYFAEVCPLFSCYGSNANPFHRLVKDLWTDSTTIHRAVQSMAIAHLSNQYPYMAPLGRAKRSQAWRSLQADLRAYRSGRISLEKVLMSCLLLGVSSPWHTPTNLGLPYLFIARTLIQGYMRTETLRPHNTLSDEKFYLDAFMYWEMLASFFEPVAMTSFPLGAPDPPILIRGEAVTPHPWTGIAPELHFALAEIGRLSRRRTNRLAMKHSDSQAMMQKDEMDCEWASSLERLVGSIQLPAPDDIVDHGDEKTSRRDLLWTTEAYRYVGLLEIYLIFPSLLSNRVNRGDSFPSMDEHVFLPPTEDTGFAKNQDAWLSTIALHALRLIKDIPLSSAACRMHLLVLAFAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9X3T6</accession>
    <name>F9X3T6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_22336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855058.1">
        <property type="nucleotide sequence ID" value="XM_003855010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X3T6"/>
    <dbReference type="STRING" id="336722.F9X3T6"/>
    <dbReference type="GeneID" id="13400973"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_22336"/>
    <dbReference type="eggNOG" id="ENOG502QVFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015119_2_0_1"/>
    <dbReference type="InParanoid" id="F9X3T6"/>
    <dbReference type="OMA" id="LHIMSGD"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGP90034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="513" mass="57805" checksum="4E8F029907CFF830" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>F9X428</accession>
    <name>F9X428_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_36872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001197">
        <property type="protein sequence ID" value="EGP90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003855177.1">
        <property type="nucleotide sequence ID" value="XM_003855129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X428"/>
    <dbReference type="STRING" id="336722.F9X428"/>
    <dbReference type="GeneID" id="13400536"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_36872"/>
    <dbReference type="eggNOG" id="ENOG502SKTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_2_1_1"/>
    <dbReference type="InParanoid" id="F9X428"/>
    <dbReference type="OMA" id="LPCMDAC"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="727" mass="81247" checksum="86F4103246BEA2F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mycosphaerellales</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
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                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 115943 / IPO323</strain>
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    </reference>
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    </dbReference>
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        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
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    <name>F9X4K2_ZYMTI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
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                <person name="Csukai M."/>
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                <person name="Kobayashi A.K."/>
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                <person name="Kourmpetis Y."/>
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                <person name="Lindquist E."/>
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                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
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                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
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                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
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                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_37332"/>
    <dbReference type="eggNOG" id="KOG1488">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004017_8_2_1"/>
    <dbReference type="InParanoid" id="F9X4K2"/>
    <dbReference type="OMA" id="CKILMNN"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="72"/>
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        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
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            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="144"/>
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        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853865.1">
        <property type="nucleotide sequence ID" value="XM_003853817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5Q7"/>
    <dbReference type="FunCoup" id="F9X5Q7">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5Q7"/>
    <dbReference type="GeneID" id="13395580"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_38293"/>
    <dbReference type="eggNOG" id="KOG1478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029944_0_0_1"/>
    <dbReference type="InParanoid" id="F9X5Q7"/>
    <dbReference type="OMA" id="WTGINWP"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46118" checksum="BA5F737E1C29ED24" modified="2011-10-19" version="1" fragment="single">LTQHHSGLGFALCCRLIDEFLYTRPQTEHLHLLFSTRDSKKGDDTKKRLQEHLAEFSRTANGTTLGISQLLDARIHLENVLVDLLKLTTVKSLAEQLLRRGQRLDAVVWNAGIPGWLGLNWAKAIWSVATDTVHATTYPEYMRPDLGAIAKPQLDGKKAGGSPEPTLGQVFTANVFGHYMLTHWLSPLMTRDTRIVWTSSISALPNSFSLDDIQGLKTPAAYECSKRLTDFLVLTSELPSAKPFMQSFLPTSKPDSTPKMYVTHPGVIGTSIAGLNAVMEFFMFLTFVFARLFGSPWHAAEPYKGAVSAVFAVLSTQLPDLEQRDGKGKWGSAVGVSGDERVARTEVDGWGFSGRVGSVPDGSVVGLRGRWRGLKQVTDESRREFEETGREVWKAMEQMREEWEARLGPLDQGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F9X5X0</accession>
    <name>F9X5X0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MYCGRDRAFT_99706</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854041.1">
        <property type="nucleotide sequence ID" value="XM_003853993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X5X0"/>
    <dbReference type="FunCoup" id="F9X5X0">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X5X0"/>
    <dbReference type="GeneID" id="13404380"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99706"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_0_1"/>
    <dbReference type="InParanoid" id="F9X5X0"/>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
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    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003391164" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="18072" checksum="70FD4AF95EE9438B" modified="2011-10-19" version="1">MLLTLALSFAFASLTPAQITTDSGLLAYTTSVGPCTTNTIPESDLVFSIQTDTVVETPGPQSACTYIVNADNPSQIVSTLTPASVIPTVSVPSTADVILISGSGSSTTSGSGAVVTETAVVSTTGGEEVTETVTRTSGGAASRTSETAVPPASTTADGAAAGRGVAGEVFGVAGFVAMVAGFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6S1</accession>
    <name>F9X6S1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_91587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854491.1">
        <property type="nucleotide sequence ID" value="XM_003854443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6S1"/>
    <dbReference type="GeneID" id="13404105"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_91587"/>
    <dbReference type="HOGENOM" id="CLU_1046654_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6S1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP89467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="266" mass="29337" checksum="D49B901CB66672FB" modified="2011-10-19" version="1">METETKAAQMSKEIGPLLRLATEELLDSSLFSDLTIICGDTYHQVHKVVLFAHGGKFREVAESAHAAITLNDKNPLVLDAVVQYLYRLEFTTPQGYELDEFMFAANVYFMAMEYGVRGLPQLALEKFAEACDPEEDLGLFVRAIRFAERMIANHDDEFWRALSRVAEAQFDFLEEQRESGGLSDHDQKSLDNLLGNIRAGDHPGSHEGSSDGGHDGDDGIGGGGAAEDDMSPAVDDQTPIFEPPIPEQRSFRIRAIICGASPRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9X6U4</accession>
    <name>F9X6U4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_103675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854477.1">
        <property type="nucleotide sequence ID" value="XM_003854429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X6U4"/>
    <dbReference type="GeneID" id="13404115"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_103675"/>
    <dbReference type="HOGENOM" id="CLU_1679345_0_0_1"/>
    <dbReference type="InParanoid" id="F9X6U4"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="157" mass="17344" checksum="1E9A8525AB4C79D5" modified="2011-10-19" version="1">MLCPKTQSSTLCQRVSESSPPSVASLRISAWTSSSTRPMLKSLHLVPVASLECRTRPIPCTALPSAVSCRMARCSRFVTSTVSRPSHPAEAADDVIWPYALQGHCTLLWLSAPVFLWAHGQKYRVPAAIVVWQFRRVRRKSRSDHISPIGRCANSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9X768</accession>
    <name>F9X768_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_108384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853613.1">
        <property type="nucleotide sequence ID" value="XM_003853565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X768"/>
    <dbReference type="FunCoup" id="F9X768">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X768"/>
    <dbReference type="GeneID" id="13395869"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108384"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.3"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_1_1"/>
    <dbReference type="InParanoid" id="F9X768"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP88589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="203" mass="23122" checksum="FA8251340900B594" modified="2011-10-19" version="1">MPESKSRWPLVWIDCEMTGLNDTKDSIMSLACFITDYDLNVLDETGYEAVIHHSQEQLDAMGEWCTSHHGSSGLTKACLDSSTTAEQAAEELLQYIQKYAPERKKALLAGNTVHADKMFLAKEPWRKVISHLHHRILDVSAIKEAAKRWAPEELIKQSPSKQGLHEAKADILESIEEARFYKRVFFQNPAEVESEQSKLPKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7A9</accession>
    <name>F9X7A9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_17058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853946.1">
        <property type="nucleotide sequence ID" value="XM_003853898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7A9"/>
    <dbReference type="STRING" id="336722.F9X7A9"/>
    <dbReference type="GeneID" id="13404284"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_17058"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060788_1_0_1"/>
    <dbReference type="InParanoid" id="F9X7A9"/>
    <dbReference type="OMA" id="KCVEYDP"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="211" mass="23957" checksum="201B743C8CC92661" modified="2011-10-19" version="1" fragment="single">SPPPPAQFQAKVSFDTFSNPAASDFSLTLNRKHRDYEYTKRSRTFLCGTDTNDYSDTALEWLIDELVDDGDEVVCLRVVEKDSKEATKWSGGQGEKGYRREAQRFLEEIEKKNTDDRAISLVLEFSIGKVQDTIQQMIRIYEPAILVVGTRGKSLTGYQGLLSSGSVSKYCLQYSPVPVIVVRPSSKREAKKRKRMQDPTRNGYRDILDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F9X7H3</accession>
    <name>F9X7H3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_70525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001198">
        <property type="protein sequence ID" value="EGP89099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003854123.1">
        <property type="nucleotide sequence ID" value="XM_003854075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X7H3"/>
    <dbReference type="STRING" id="336722.F9X7H3"/>
    <dbReference type="GeneID" id="13404462"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_70525"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_3.1095"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="InParanoid" id="F9X7H3"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
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                <person name="van Ham R.C.H.J."/>
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                <person name="Maliepaard C."/>
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                <person name="Nap J.P.H."/>
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                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
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                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
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                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
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                <person name="Oliver R.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
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                <person name="Conde-Ferraez L."/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="664" mass="72478" checksum="F94268288714B1C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8B6</accession>
    <name>F9X8B6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_41022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853500.1">
        <property type="nucleotide sequence ID" value="XM_003853452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8B6"/>
    <dbReference type="FunCoup" id="F9X8B6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="13400621"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41022"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.258"/>
    <dbReference type="eggNOG" id="ENOG502QZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062681_0_0_1"/>
    <dbReference type="InParanoid" id="F9X8B6"/>
    <dbReference type="OMA" id="TTDMVRC"/>
    <dbReference type="OrthoDB" id="5420410at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="280" mass="30843" checksum="B1B0ED17E1103A53" modified="2011-10-19" version="1">MYAHQPSGDFILSPPASSIASTTTSATLPHPRDSPLRPGGTKEGTFIRYVDQKLLHIQRRFAKRTTPSTAFLSDIDREKADAWGDVRGYATMKEACRDFDELIGVVWVSGTMSLQVPYLISIALLVGNVVQAMPPTPRSLFRTLGKLDHAFASLLQGRDVETGERLPGFEGIRGVSGTEKVRIRSLVERTRVNIVEAFKKGEFEVEDKEDMDADRMDTDTDGELVLEGGEDDVDEEEDDSFDMQIARVYDKTVVELGDSLEQPNIGIITESRAWGGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9X8U4</accession>
    <name>F9X8U4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_40264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853545.1">
        <property type="nucleotide sequence ID" value="XM_003853497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X8U4"/>
    <dbReference type="FunCoup" id="F9X8U4">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X8U4"/>
    <dbReference type="GeneID" id="13400666"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40264"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="InParanoid" id="F9X8U4"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="369" mass="42829" checksum="6FACEED33D4CCE5E" modified="2011-10-19" version="1" fragment="single">HGVPRVAGGIPDKSEQTREKERKHIEQYKQLESEVTEKIRAKDYSNTTLQLTSKLLSANPEYYTIWNYRRLILEDVFAKELETKADSVEEGDAAAAQEAGLTTAQREIALLVKEDLQFLVPLLKQYPKCYWIWNHRSWLLATATKHVPPHGTLPLWQAELGLVSKMLSLDSRNFHGWGYRRDVVKNLEDLSGKSMVEPEYEYTTKMIQSNLSNFSAWHNRGQLIPRLLNERQADSAQRKELFDAEFELVTRALYTDPYDQSLWFYHQYLMSALDSKNPHAPEILSPCTNSDRLHYLEQEIDSIREMLDGAEDCKYIYQALLEYAPRYFVVEAGNKAITPAEMTDWLDELKKIDPLRAGRWEDLGRALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F9X968</accession>
    <name>F9X968_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">MYCGRDRAFT_71621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853157.1">
        <property type="nucleotide sequence ID" value="XM_003853109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X968"/>
    <dbReference type="FunCoup" id="F9X968">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X968"/>
    <dbReference type="GeneID" id="13399521"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_71621"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.813"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="InParanoid" id="F9X968"/>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGP88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="252" mass="27832" checksum="E5FFDFB2A503576A" modified="2011-10-19" version="1">MSASTPFAELSTTDADALIISDDPLHPANHIPTLCKQFYTHGWVTGTGGGISIRHGDHVYLAPSGVEKELMSPKDIFVMDWKSGEYLRRPEVFKPSACTPLFLSTYKVRDAHCCIHTHSQWAVLITLIVGTGKQNNGATDHFAIREIEQIKGLSRTGTGSTTIAEGGRKLGNLGYFDTLKVPIIENTAHEEDLKDSLEAAMKEWPEACAVLVKRHGVYVWGRDVVQAKTQAESLDYLFRLAVEMHGLGLQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>F9X999</accession>
    <name>F9X999_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_92897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853208.1">
        <property type="nucleotide sequence ID" value="XM_003853160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X999"/>
    <dbReference type="GeneID" id="13399725"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_92897"/>
    <dbReference type="eggNOG" id="ENOG502R8X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_866558_0_0_1"/>
    <dbReference type="InParanoid" id="F9X999"/>
    <dbReference type="OrthoDB" id="3646601at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="321" mass="35378" checksum="37259BB8436C4AC1" modified="2011-10-19" version="1">MLRVVQSIINTCTCMLHDDLSFDANVAPFASERREASALTSQQPTCAFHLHDTTSIDSHGGPRFAPLTSTSAPALRRSKRIKNAIQSSNASSGAVKRKRKRPSSADAVSRPGAKSAKTNSKSRRDDLPNQSQEKKARNTASDETSEAASQNPSSIASVPDGEQPFRLFDLPDELWVKIGQMATEDLPAIGEFLPDRHPNRRHELSKLFSKLKTPAILQTCSALRKELRLHYYGSNKIRVTIDELSAVGVLRPYLQAIGLSARRLLDGFTMIGRVDWDADAVLEPPHDLPASWGVELVLSLVSRDPCEGCEADHVDWKITFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9C4</accession>
    <name>F9X9C4_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_99833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852875.1">
        <property type="nucleotide sequence ID" value="XM_003852827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9C4"/>
    <dbReference type="GeneID" id="13397196"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_99833"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.171"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="InParanoid" id="F9X9C4"/>
    <dbReference type="OMA" id="NPYTHHP"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="553" mass="62119" checksum="94B5F47B9876F4CD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9E3</accession>
    <name>F9X9E3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MYCGRDRAFT_108995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853527.1">
        <property type="nucleotide sequence ID" value="XM_003853479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9E3"/>
    <dbReference type="STRING" id="336722.F9X9E3"/>
    <dbReference type="GeneID" id="13400648"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_108995"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.192"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471090_0_0_1"/>
    <dbReference type="InParanoid" id="F9X9E3"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="12">
        <location>
            <begin position="398"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGP88503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="579" mass="64461" checksum="69CFBEC2F3EBB362" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9L6</accession>
    <name>F9X9L6_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_41337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853434.1">
        <property type="nucleotide sequence ID" value="XM_003853386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9L6"/>
    <dbReference type="STRING" id="336722.F9X9L6"/>
    <dbReference type="GeneID" id="13400404"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41337"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="F9X9L6"/>
    <dbReference type="OMA" id="PWNSNAG"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="473" mass="50114" checksum="5144D396FA909834" modified="2011-10-19" version="1" fragment="single">YVPSSSGETLSIFSPNDDSLVTDKVQVASEQDVDSCVAAARAAFPAWRDTAGHKRAAIMLKFADLLEANIEKLAKLESAAMGQPISVAKKFILGPIALWRYYAGYAGKVAGESYPPDEDGTYKIVSYEPLGVCAGICAWNGSHVLAAWKMAPAMATGNTFILKSSEKSPLSLAAYGNLINEAGFPPGVINIITGAGPTGSLLASHMKIDKIAFTGSSVAGRAVMAAAAKSNLKHVSLELGGKSPALIFDDADLDNAVEHSSTSFLRNSGQICFAASRVLVQENIAPKFIEAVKTAFENAAKLMGDPNLEETAFGPLADKKQFERVMSFLDGAKQEGVQVLVGGERKGDKGTFVTPTIFLNPDLNSKVYTDEIFGPAISIKTFKTEDEAIEMANNTSYGLGSTIYTSDIARALRIASKLEAGTVGINSAFATSPQTPFGGFKQSGYGRESGIEGLKNYLQPKTIHVNMNVPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F9X9S4</accession>
    <name>F9X9S4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MYCGRDRAFT_40048</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853086.1">
        <property type="nucleotide sequence ID" value="XM_003853038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9X9S4"/>
    <dbReference type="FunCoup" id="F9X9S4">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9X9S4"/>
    <dbReference type="GeneID" id="13399995"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_40048"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.618"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="InParanoid" id="F9X9S4"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="PHI-base" id="PHI:4944"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="21">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP88062.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="726" mass="81487" checksum="73C52DED62D6375A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F9XA20</accession>
    <name>F9XA20_ZYMTI</name>
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        <recommendedName>
            <fullName evidence="4">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MYCGRDRAFT_104261</name>
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        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001199">
        <property type="protein sequence ID" value="EGP88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003853098.1">
        <property type="nucleotide sequence ID" value="XM_003853050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XA20"/>
    <dbReference type="FunCoup" id="F9XA20">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="13399977"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104261"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_4.651"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_0_0_1"/>
    <dbReference type="InParanoid" id="F9XA20"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
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        </location>
    </feature>
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        <location>
            <begin position="24"/>
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        </location>
    </feature>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="EGP88074.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21926" checksum="34D0021C019FAC18" modified="2011-10-19" version="1">MGSGGSKQEQHVFNADAPVRLSQSVVNSLQNSPESDTTRAQDYELKIQSRVHEELRKTRENQAKRLDSLTASLTTNQPKPEESSPKSEGENSGLFATLSSPFYHDWSAKEKGSKTANVDSGRSSDSVNNEIMDLRKKLDSRKKVEKVPKELEKAKESLVSCLRNNDRRPLDCWEEVQSFKTEVGKLEKAFIQKAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XAQ7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_93009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852065.1">
        <property type="nucleotide sequence ID" value="XM_003852017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XAQ7"/>
    <dbReference type="STRING" id="336722.F9XAQ7"/>
    <dbReference type="GeneID" id="13397075"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93009"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.98"/>
    <dbReference type="eggNOG" id="ENOG502SAVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438133_0_0_1"/>
    <dbReference type="InParanoid" id="F9XAQ7"/>
    <dbReference type="OMA" id="RTWENED"/>
    <dbReference type="OrthoDB" id="5427204at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="597" mass="65682" checksum="F786ADCB8A2D51BA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB24</accession>
    <name>F9XB24_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Subtilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MgSPR2</name>
        <name evidence="19" type="ORF">MYCGRDRAFT_10819</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852442.1">
        <property type="nucleotide sequence ID" value="XM_003852394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB24"/>
    <dbReference type="FunCoup" id="F9XB24">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XB24"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="13394146"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10819"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="InParanoid" id="F9XB24"/>
    <dbReference type="OMA" id="PWMHVKH"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="469"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="739"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGP87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="797" mass="88231" checksum="CD0BF74B14EBC0FE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>F9XB26</accession>
    <name>F9XB26_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MYCGRDRAFT_42691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852370.1">
        <property type="nucleotide sequence ID" value="XM_003852322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XB26"/>
    <dbReference type="STRING" id="336722.F9XB26"/>
    <dbReference type="GeneID" id="13394218"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42691"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="InParanoid" id="F9XB26"/>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="601"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP87346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="984" mass="107392" checksum="2B7415A20C139DCF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBF1</accession>
    <name>F9XBF1_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_72393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852269.1">
        <property type="nucleotide sequence ID" value="XM_003852221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBF1"/>
    <dbReference type="STRING" id="336722.F9XBF1"/>
    <dbReference type="GeneID" id="13396859"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_72393"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.560"/>
    <dbReference type="eggNOG" id="ENOG502SJ96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052363_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBF1"/>
    <dbReference type="OMA" id="WHEWALE"/>
    <dbReference type="OrthoDB" id="5283561at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP87245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="498" mass="55112" checksum="E66F24227220354D" modified="2011-10-19" version="1">MTNITHLPHEILTTILLLATKANERENESFTYGLTQAPLPLQQTKLTKYVRGPVTAESLRWDATVSIRQVCSAWHEWALSYNLEHVFERRWRGSERWAELSPNRRKYSLYELMEKPSGCAVYRDPLSSLRSTDRAFTQLPHLTQHVRRLWFNGFYTADSDKHILSIVAECSHLQFLSVPWTILRRGTAEDWIDLLNVDGEGTPLHSLELQAVCLPSAQALTLESDAASNPNPLLDPRVSFSHLHRLKIFGNTLHNPISDTDISLIARTATSLHALDITNLSTVSVAAVLELVHASRHTLQVLEHSPRSSDGFYHPYPGAIPDSTHICTLLTSLPKLRDLSISVPTLCPDLFRAVDDVKWEGDFQVRATDLCGCHPSTSTATRTALLGSTLSAARDLIAARARLGRNLSIEIFFNGCIFEPGKNLVHGDFVLAEVASRGAFPRGVSGDAGEREGSMKGPYGTTGVYGKDLSDGEGGRGSWDQVWEGEFLEAGGRGWVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XBR5</accession>
    <name>F9XBR5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_10126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852518.1">
        <property type="nucleotide sequence ID" value="XM_003852470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XBR5"/>
    <dbReference type="FunCoup" id="F9XBR5">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XBR5"/>
    <dbReference type="GeneID" id="13396841"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_10126"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="InParanoid" id="F9XBR5"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="195"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="353"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="878"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="126301" checksum="706512EEF2680C7D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCL2</accession>
    <name>F9XCL2_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_42493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852220.1">
        <property type="nucleotide sequence ID" value="XM_003852172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCL2"/>
    <dbReference type="STRING" id="336722.F9XCL2"/>
    <dbReference type="GeneID" id="13396919"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_42493"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.439"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_2_1"/>
    <dbReference type="InParanoid" id="F9XCL2"/>
    <dbReference type="OMA" id="AGWNAMF"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="323"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP87196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="439" mass="46935" checksum="AECC00D00E746741" modified="2011-10-19" version="1">MTSTKPKVGFAGLGAMGGGMAKNLVKEGFSVTGFDVYQPLVDSFVEAGGKGAKTPREAASEAEFFVSMVANNTQTISLLFEGEDCLIKGLGKNKTFILCSTTPPSFLPELRRRLDDEGRPDIKLLDCPVSGGTIRAANGTLSIFESGPVEHLDEAKEVLQCMSANLYRMGAISDGTKTKTVHQLLAATNIITASEAMGLAATVGLNTDAVAEHVNKSDGASFMFENRVPHMLKNDWHPYSALGIILKDATIVTHTARSSQFPTPLADTAEQLYLQGVRAGLLKVDDAALVQLYLPATQPSLVHEMTSADINMSASHKVSKDTIVDLLTGIHLAASVEGMAFCKSLGLDRKTLCEIISKAAGWNAIFVKCIPDMLEKDEWSLADCPQAEEVGRKLGEAVEKCGRIGFPCMMGSAALQQFAFAGLKAKKIGGQDRRSREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XCL7</accession>
    <name>F9XCL7_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_41530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001200">
        <property type="protein sequence ID" value="EGP87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003852594.1">
        <property type="nucleotide sequence ID" value="XM_003852546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XCL7"/>
    <dbReference type="STRING" id="336722.F9XCL7"/>
    <dbReference type="GeneID" id="13393998"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_41530"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_5.445"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_1"/>
    <dbReference type="InParanoid" id="F9XCL7"/>
    <dbReference type="OMA" id="QDCFWES"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="257" mass="27319" checksum="CEF69FE3635CF18B" modified="2011-10-19" version="1">MPPLPAAREKRLVGTSLKLYFDLPSTLRYVDSVALLSSAAEKANVDLFVIPDFVSLLPAKDKLAKTSVWLGAQDSFSEDKGAYTGEVSPLTLSQAGVKIVELGHAERRRLFGETDADVAKKAAAVVNNGMIPLICIGEKNRSTIASQAVGIAVDECKPQIEAALSQIPDDAEVILAYEPVWAIGAAEPAGADHVVAVTQNLRALCAGRKGRTRILYGGSAGPGIFTKLKEGVDGLFLGRFAHDVKNLEKVIEELAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDC3</accession>
    <name>F9XDC3_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_93883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851848.1">
        <property type="nucleotide sequence ID" value="XM_003851800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDC3"/>
    <dbReference type="GeneID" id="13401550"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93883"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.336"/>
    <dbReference type="HOGENOM" id="CLU_1289866_0_0_1"/>
    <dbReference type="InParanoid" id="F9XDC3"/>
    <dbReference type="OrthoDB" id="10275608at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="214" mass="24515" checksum="52A820FB28646968" modified="2011-10-19" version="1">MRVDQPSTPPSRSIEMSTRPSSELLYIPYLIASSYGLPASHLSLLTTSLIFYFHYNHDLSWLSILRNPRLWLTLPAADTTILLWMLYMSKHGFFANKSIVDSPSARKPKMEETPQEFSGQTSCPTTVMSRFNTQFRTQFHGSEPQVFGFPSSGGILTTRFDLAVAGFFDLFGWKSSSEQRIRMKKMHSAIVCGCSKWKGWKSEYDFVMKKIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F9XDX1</accession>
    <name>F9XDX1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_43335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851589.1">
        <property type="nucleotide sequence ID" value="XM_003851541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XDX1"/>
    <dbReference type="SMR" id="F9XDX1"/>
    <dbReference type="FunCoup" id="F9XDX1">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XDX1"/>
    <dbReference type="GeneID" id="13402036"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43335"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.552"/>
    <dbReference type="eggNOG" id="KOG3470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130569_0_2_1"/>
    <dbReference type="InParanoid" id="F9XDX1"/>
    <dbReference type="OMA" id="DENREYM"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="102" mass="11550" checksum="2ACB27B50913209C" modified="2011-10-19" version="1">MPAPSQLSIATSALNRLVKEKASYHKEFEQQQATIAKLEAEQSTSEDENAEYTLRQERKALEETKAMFPQLKTKIEDTKAKLESQLVSFLVHTQAMQSFCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE11</accession>
    <name>F9XE11_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_43924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851736.1">
        <property type="nucleotide sequence ID" value="XM_003851688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE11"/>
    <dbReference type="STRING" id="336722.F9XE11"/>
    <dbReference type="GeneID" id="13402024"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43924"/>
    <dbReference type="eggNOG" id="ENOG502RX5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1929247_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE11"/>
    <dbReference type="OrthoDB" id="3798483at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="131" mass="14466" checksum="BABB35CFDC33866A" modified="2011-10-19" version="1">MLSAAQRAIYNKVLKHARAQIVTRQVVAPLLLNINSKAGTSKSFIIEVISAHLQALISNYEDVIFCAAPTGAASYSIAGLTLHTLLRLPTKGEFHLLGVRQLAHLQRKLRRVLYIIINKKSIVGLETLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE33</accession>
    <name>F9XE33_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_43851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851328.1">
        <property type="nucleotide sequence ID" value="XM_003851280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE33"/>
    <dbReference type="STRING" id="336722.F9XE33"/>
    <dbReference type="GeneID" id="13393780"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_43851"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.14"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="InParanoid" id="F9XE33"/>
    <dbReference type="OMA" id="AFEVYNL"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="418" mass="46305" checksum="B0E12F1E12025F9E" modified="2011-10-19" version="1">MASSPAFQIIIVGGGIAGTSAAIALRAPGRQITILEQSRLHAEIGATISLQPNASRILEEGWKLGGLLTTTARGMVDRGFRIFNVDGEKVGEIPLKTKSKYGADRVMFHRQDLHECLKQAAMAEERDGPAVEIRVSSRVVSCDCEAGIAVLENGEELKADLIVAADGIHSVLRRCILDEDVAPIPTGLSLYRFMLLTEQLEKEAPDFCSKIHSREPYTSMLFAHDCRLISGPARDASVYSIVGLVPDERMNEDADGKQSWRSTGDLDKALQSFKDFPDWVKQPFRLAKDLGLWQLRDLPPLRTWTKGRVILIGDAAHAMLPTQGQGASQAVEDAEALGAFFEGVRDIPSMEEVNSLLLQVFKCRYERATLIQKYSRDAARPPTEKGSNEVKMRPDEFMDYNCLYRGAKEWQSRRVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE39</accession>
    <name>F9XE39_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_93618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851999.1">
        <property type="nucleotide sequence ID" value="XM_003851951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE39"/>
    <dbReference type="GeneID" id="13393776"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_93618"/>
    <dbReference type="HOGENOM" id="CLU_708239_0_0_1"/>
    <dbReference type="InParanoid" id="F9XE39"/>
    <dbReference type="OrthoDB" id="5419711at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44102" checksum="009C60C73618DDD6" modified="2011-10-19" version="1">MPGNGPESPTLHGMSLEANATPDPTGAVAPDYEDLDPKDLLTPEQRAKKLIRSLAARIILVDTEVSSYLAFKERTGKLSRYILQEDVASTLIKLYDICGHFSDRITQQRAVGKYYWPSRFHDIVKHCRETAGRALHPGRSRLLHSIPIRTTLGADITPEDQVRVQSILDKMKTDLSALLLASLAEEHHAVRLARLDEIRTSTLDRRLRYQMKLAEDDKKRGPALKAGDAVLVRRLQQDQEHGHKFEVKYDSLYILEKITSSGQAGILKSMHGESPLQGKKYYLNDLRLFVPDSEGRWKKTSKANRAIQLKLRGEVNQRRKFKKHNKERVAQGLPELPNPDRRHHPAIDDPLGPRDVSWNPSIGIGEPAKADETSTAYWDRKSVALSDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F9XE67</accession>
    <name>F9XE67_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MYCGRDRAFT_73474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851623.1">
        <property type="nucleotide sequence ID" value="XM_003851575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XE67"/>
    <dbReference type="FunCoup" id="F9XE67">
        <property type="interactions" value="1128"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XE67"/>
    <dbReference type="GeneID" id="13401834"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73474"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="InParanoid" id="F9XE67"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="9">
        <location>
            <begin position="530"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGP86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="712" mass="78929" checksum="A5C831CC82E12800" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>F9XED2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">MYCGRDRAFT_104723</name>
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    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851346.1">
        <property type="nucleotide sequence ID" value="XM_003851298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XED2"/>
    <dbReference type="GeneID" id="13401238"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_104723"/>
    <dbReference type="HOGENOM" id="CLU_2924490_0_0_1"/>
    <dbReference type="InParanoid" id="F9XED2"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="61" mass="6698" checksum="FC436BD3F9BA57D5" modified="2011-10-19" version="1">MLRRGGLSSHGSAPLQQYFGGLGRITRSVQMCSKGSRDTSATHCIVMLEHPGSRQHCDYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F9XEH2</accession>
    <name>F9XEH2_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_73531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001201">
        <property type="protein sequence ID" value="EGP86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003851599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XEH2"/>
    <dbReference type="FunCoup" id="F9XEH2">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XEH2"/>
    <dbReference type="GeneID" id="13401858"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_73531"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_6.663"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="InParanoid" id="F9XEH2"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CULLIN"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CULLIN_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="438"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="827" mass="94360" checksum="59640AF276BDE53C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF31</accession>
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        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MYCGRDRAFT_45343</name>
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    <organism evidence="5 6">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851231.1">
        <property type="nucleotide sequence ID" value="XM_003851183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF31"/>
    <dbReference type="STRING" id="336722.F9XF31"/>
    <dbReference type="GeneID" id="13397375"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45343"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016103_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF31"/>
    <dbReference type="OMA" id="DVRSSNW"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGP86207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="421" mass="47119" checksum="22CE8D81D4C01538" modified="2011-10-19" version="1">MSADTHRSAAMASRNTDAAYWHHKLYKGPEGDTPKVLYCSKFEVSEKRAQLFLNEPILGFDIEWEPGANEKSGPKKNVSLIQLAAGDKIGLFHVAYFDGKSVEQLMPPTLRKILEDPNVTKAGVNIGGDATRMRKWLDVDMKGVFELSHLFRIVKHEGGVNFKPVSMAKQVQTILHLPIKKDDVRMSDWSRPLNVEQTHYAAADAYAGFMLYHTLDNERKLMKPKPPLPAFYETGGPLVLGTGEMIHKGGKRTAGPVVTVDASAAGEIEQEGEEFYDALDALDHLDLNSGIAFAPSKREKATAAPLPKSTPAKNNPLPCPENQRADTWIRTRRAESAADLKRPASDSVMRAYHLWHVQHFELNEVARFCRDPPLTMNTVASYVMDAIEKENLPFEQDRLKQAASVLPTAVQRRYRHLLRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>F9XF75</accession>
    <name>F9XF75_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MYCGRDRAFT_94802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850900.1">
        <property type="nucleotide sequence ID" value="XM_003850852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XF75"/>
    <dbReference type="GeneID" id="13397638"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94802"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.776"/>
    <dbReference type="HOGENOM" id="CLU_826934_0_0_1"/>
    <dbReference type="InParanoid" id="F9XF75"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="336" mass="37200" checksum="5B6F94834CC5BEDB" modified="2011-10-19" version="1">MVPVTVIMGLDGSISGAVNPIVSTSSINLSPTQALPCPILKLPAELIGSICMYLTPNIRLKVQRMVYGLGGHGHLVTVLNPQDWRAYHNFSMTRWELRAKCLGAIKSARKTRDLVLIMEMERHTNDPTSQLELGKAPFTSKVRSLMTFLNKFNGLEISTVISMSKAVHGAQPAAYTPGDDKLTKRTTVMIDIAKPLRRDRAPHPADLSNIVSIEEEILWDTVKPADAAAFAAVQANMQYVLDFPVQTGVNVEVPYLPTITGKGLHELGLVLAVRAREYAMQQVDVVSGHEELIIKKHKSTIKWLGCIERWRTERAKRKAEEEAARAEQADSEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFC3</accession>
    <name>F9XFC3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_60715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851211.1">
        <property type="nucleotide sequence ID" value="XM_003851163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFC3"/>
    <dbReference type="GeneID" id="13397393"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_60715"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.219"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_0_1"/>
    <dbReference type="InParanoid" id="F9XFC3"/>
    <dbReference type="OMA" id="HIKSWVP"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF1">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE STCW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="70324" checksum="D76D43052E546B50" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFJ6</accession>
    <name>F9XFJ6_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_94401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851198.1">
        <property type="nucleotide sequence ID" value="XM_003851150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFJ6"/>
    <dbReference type="STRING" id="336722.F9XFJ6"/>
    <dbReference type="GeneID" id="13397938"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_94401"/>
    <dbReference type="eggNOG" id="ENOG502S3PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061001_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFJ6"/>
    <dbReference type="OMA" id="IRCHADW"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="242" mass="27695" checksum="C8BDDE682C1FC3B0" modified="2011-10-19" version="1">MDSHQQDELAALFAQSMHVSFAPPQQTAVVQQEVIIESLPQQTFDEKTPITYISAHYTHSTHLAPTNHSSPSTSPPPPYASPFPPAMQDTQTMPEAMAQTLLQHSIDPATLLPSQIHLFLHADYEQRLRLLELWRISPPSYAVDQARYEQTTIEAEERQAKMRFEEHLREQAKAFQQLQKHSEEVAEVEPYIVNGYDADQSKHSVDPVYAATAMQDQYGRYEQMRCHADWERMNGGDDEMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFM0</accession>
    <name>F9XFM0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MYCGRDRAFT_44978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP86161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003851185.1">
        <property type="nucleotide sequence ID" value="XM_003851137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFM0"/>
    <dbReference type="FunCoup" id="F9XFM0">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFM0"/>
    <dbReference type="GeneID" id="13397925"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_44978"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="InParanoid" id="F9XFM0"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGP86161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="195" mass="21423" checksum="0D005F7DA8070A53" modified="2011-10-19" version="1">MLTFCFVYFAQNVEAAKGPKITCKVYFDILHGEEDLGRIVIGLYGGTVPKTAENFRALATGEKGYGYEGSTFHRVIKQFMIQGGDFTRGDGTGGKSIYGEKFQDENFKLKHSKKGLMSMANSGKDTNGSQFFITTAITSWLDGKHVVFGEVLEGYDIVEKIENVPKGSGDKPSKTVKIKKSGELEVPEEGIRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFP4</accession>
    <name>F9XFP4_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MYCGRDRAFT_19773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850688.1">
        <property type="nucleotide sequence ID" value="XM_003850640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13397913"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_19773"/>
    <dbReference type="eggNOG" id="ENOG502QUFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="InParanoid" id="F9XFP4"/>
    <dbReference type="OMA" id="RRIYHMP"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="11">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="9">
        <location>
            <begin position="1923"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="10">
        <location>
            <begin position="2273"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="3016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGP85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="3016" mass="336758" checksum="6DBEEF30A5C5791D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>F9XFU0</accession>
    <name>F9XFU0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane BAX inhibitor motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MYCGRDRAFT_74012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850711.1">
        <property type="nucleotide sequence ID" value="XM_003850663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XFU0"/>
    <dbReference type="FunCoup" id="F9XFU0">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XFU0"/>
    <dbReference type="GeneID" id="13397449"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74012"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.355"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="F9XFU0"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGP85687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30727" checksum="1C0127AD7F28432F" modified="2011-10-19" version="1">MAANTKYTPAPQRDSFEEQGYSQPPPSYQAEPVMGEARSEDDNIPDDFKFGGSVAEATLPIRMQFIRKVYAILTVQLLATVALSAISFFSDGYRKWIQSNQWMMWVSLFGAIGFMLLTFWKRKSYPMNLAFLSGFTALEAYSISVITSFYESRIVLQALIFTLGIFVFLSLFACQTKYDFTSWMPYLFGALWVLILFGFMTMFFPQTKGVELGYGIAAALIFSAYILVDTQLIMRHYHVEEEIAAAISLYLDVLNLFLAILRILNSQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGA0</accession>
    <name>F9XGA0_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MYCGRDRAFT_74210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850777.1">
        <property type="nucleotide sequence ID" value="XM_003850729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGA0"/>
    <dbReference type="FunCoup" id="F9XGA0">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XGA0"/>
    <dbReference type="GeneID" id="13397515"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_74210"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_7.510"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="InParanoid" id="F9XGA0"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
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        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
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            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
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            <begin position="228"/>
            <end position="433"/>
        </location>
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        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGP85753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="457" mass="51923" checksum="1C9E220FEA9863AC" modified="2011-10-19" version="1">MDLIRRAGAFLDSPTIPWKTLILSFSVGQYAIETFLAYRQHRVLQRTTVPEQLKQEIDQETFDKSQAYGRAKSKYNFYSNAFQLIKNYFIITHDAYPRLWTLSGLWISRYAPARFSGEITHSLVFVFAYSFAEKLISLPWETYYHFVLEESFGFNKQTLSLFLSDLVKGQALALAFGIPLGAAFLKIIQSTGEKFFLYIWIFMLVVQLGAISIYPTLIVPMFNTLTPLEPGDLKDRVNALASKLNFPLAELQVIDGSKRSAHSNAYFTGLPFTKKKIVLYDTLINKSSPPEVEAVLAHELGHWQMGHTSKLLGISSFHLFYVFALFGVFINNKSLYEAFGFGGRMGQPIMIGFLLFNEVLSPTDSLVKLGMNMLTRKFEFEADAFSLKLGYAKELAASLIKLQIQNLSSMDADHMYSSYHYSHPILTERLKAVGWTSEKKISTEKPAVKADEPRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGH5</accession>
    <name>F9XGH5_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_45154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001202">
        <property type="protein sequence ID" value="EGP85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850586.1">
        <property type="nucleotide sequence ID" value="XM_003850538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGH5"/>
    <dbReference type="GeneID" id="13395298"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_45154"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="F9XGH5"/>
    <dbReference type="OMA" id="TSNRWAW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58515" checksum="D75564D1AA7C986D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F9XGX8</accession>
    <name>F9XGX8_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein NAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NFA2401</name>
        <name evidence="4" type="ORF">MYCGRDRAFT_105379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850459.1">
        <property type="nucleotide sequence ID" value="XM_003850411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XGX8"/>
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        <property type="interactions" value="1564"/>
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    <dbReference type="STRING" id="336722.F9XGX8"/>
    <dbReference type="GeneID" id="13402752"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105379"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_8.210"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="InParanoid" id="F9XGX8"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
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    </dbReference>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGP85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="403" mass="45522" checksum="42682824F102D902" modified="2011-10-19" version="1">MSEPIRNNRSQAQTAPTPQNTPANAAPISSHAAAPGMSSINEEELDRAAAASIFAQNPRLVSMMQNKLQGLVGKSSGYVESLPAPVRKRVAGLKGVQKEHSKLEAEFQEEVLQLEKRFFAKFTPLYEKRAAIVNGAAEPTEAEIEAGEEDEEDDEEAEAAKAEADKDASAADLKGIPEFWLSAMKNSSLAETITDRDEEALKFLTDIRMEYLDRPGFRLIFEFSENSFFSNKILNKTYFYQEENGYGGDFIYDHAEGDKIDWKAGQDLTVKIESKKQRNKNTKQTRIVKKTIPTPSFFDFFNPAAPPEDDDDEIDEDIEAKLELDYQLGEDIKEKLIPRAIDWFTGEALQFEQGLDDFDEDDFEDEDDEDDDDDERDEDDEDEDDDEEDGSRPKQETAECKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH60</accession>
    <name>F9XH60_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_46779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849973.1">
        <property type="nucleotide sequence ID" value="XM_003849925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XH60"/>
    <dbReference type="GeneID" id="13402767"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46779"/>
    <dbReference type="eggNOG" id="ENOG502SCNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_4_1_1"/>
    <dbReference type="InParanoid" id="F9XH60"/>
    <dbReference type="OMA" id="EYPDCIT"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22348" checksum="3B8EA7C933033523" modified="2011-10-19" version="1">MSNKLETQSPFLREPWLASQLQHPDTVIRVTPSREPKASTEDSLFAEILKTDRTIQSCLSFYSTSKSEDGIEEVTTLIAMGNGMNGHPQILHGGITATLIDESMGIFQSVDHSYQTGKMTQGAEESFAGTFTAQLTVRYLAPVRTPGCVEVKVRSVKKEPRKEWLKAEVRQWVGDKEGGEAVLVADGEALFIKPRVGPRAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F9XH87</accession>
    <name>F9XH87_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_105409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850434.1">
        <property type="nucleotide sequence ID" value="XM_003850386.1"/>
    </dbReference>
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    <dbReference type="STRING" id="336722.F9XH87"/>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
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</entry>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGP85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="128" mass="14356" checksum="9207108EC59348DD" modified="2011-10-19" version="1">MPSTIPTITPSATTYASLINHKTGEIHTVRIVANPSTNTTETYTPFSFLPNHGISSVYSSEEKKSTSSSAASSTDSFDSVREMKIEMSGEVQGRRVYLSKRERVAARFGVWRREQREFWNMVGPVMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIS9</accession>
    <name>F9XIS9_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MYCGRDRAFT_46098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001203">
        <property type="protein sequence ID" value="EGP85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003850149.1">
        <property type="nucleotide sequence ID" value="XM_003850101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIS9"/>
    <dbReference type="FunCoup" id="F9XIS9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="13394425"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_46098"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="InParanoid" id="F9XIS9"/>
    <dbReference type="OMA" id="APHIYLI"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGP85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40040" checksum="23AEC9627693C16B" modified="2011-10-19" version="1" fragment="single">VSAETVRISNSQGRRLHKHVGVFIGGTNGIGESTAKEFFIRTASPKAYIVGRNRERGERLCKTLHGLNSEGTAIFIQADVSLLKNCDELCEDLKRREKKIHFLILTAGYMTLKGRNETPEGIDRKMSVNYYSRVRCTLHLMPLLEAASKANELSRVITVLAAGSEADVRVDDLDLKHNFSLQACLAHCVLMNDFAIEELAKRYPGTSFSHSYPGTVKTGIANELTGVVRLAVKVLYAVMTPWILNVQDSGERHFFQMTSNCYPSKQGAAGIPIPDGLSPMRGTDFVPGSGAYLLDWDGKATGDEKVLKKYRAMNFGQTVWDHTMAIFAQADRTMRKDSKRPADGEAEGAGRSIPNPVGWRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F9XIW1</accession>
    <name>F9XIW1_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">MYCGRDRAFT_110776</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849423.1">
        <property type="nucleotide sequence ID" value="XM_003849375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XIW1"/>
    <dbReference type="FunCoup" id="F9XIW1">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="336722.F9XIW1"/>
    <dbReference type="GeneID" id="13402476"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_110776"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.366"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="InParanoid" id="F9XIW1"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="137"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGP84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="482" mass="52591" checksum="38E627DFCD04AE55" modified="2011-10-19" version="1">MALPGLSLPGLNLPQTSSTPLADSKNTIQASRLEDLPSRTEWRFEVAFSQHYSIKLESGHAEMFGVELALKQVYTFSGFKGAIFTWQGCQLEVTGNAESEYIGQETDYAVEWLNVHGMLDTLRSQNPTDGPRVLVVGPDFVGKTSLVRTLAAWEARSGYTPTVLNLDPREGILAPPSSLTAVTVDSQLEVDSGYGIPSSSGPTLSPVRTPLIYHFPYASPLEKPEVYKAVVTRMALSVMNKLEENQATKRGGIIVDTPGTLNDPRSNYDLIAHLVSELSITIILTLGSERLSSDMTRRFGGNKSPDELVTVLRVAKPGGAVERDHDFMKQLNREQTRQYFFGPGNTLNPHSHSASFADLDLFRAKSASVAASEDHGFAPGDENDDDFDVPYASKPSGGQYATFEKTTPTAAMTGSLVAIKFCPGSSEEHVVRDSAVMGFLYVADVDEVRKKVRFLAPHPQRWGDRALVWGHGWPEAVADLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJ16</accession>
    <name>F9XJ16_ZYMTI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MYCGRDRAFT_105651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849822.1">
        <property type="nucleotide sequence ID" value="XM_003849774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJ16"/>
    <dbReference type="GeneID" id="13402619"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_105651"/>
    <dbReference type="HOGENOM" id="CLU_2672999_0_0_1"/>
    <dbReference type="InParanoid" id="F9XJ16"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGP84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="75" mass="8988" checksum="7027B3133939585D" modified="2011-10-19" version="1">MLSKWNGFGFIVASARILRHAGYESEARWMLDIGRLEMPDFFTMKHRRSRPSEHAKLGQWAHIQRRRGLLYTYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F9XJT3</accession>
    <name>F9XJT3_ZYMTI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MYCGRDRAFT_47858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Zymoseptoria tritici (strain CBS 115943 / IPO323)</name>
        <name type="common">Speckled leaf blotch fungus</name>
        <name type="synonym">Septoria tritici</name>
        <dbReference type="NCBI Taxonomy" id="336722"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Zymoseptoria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002070" last="E1002070">
            <title>Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.</title>
            <authorList>
                <person name="Goodwin S.B."/>
                <person name="Ben M'barek S."/>
                <person name="Dhillon B."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Crane C.F."/>
                <person name="Hane J.K."/>
                <person name="Foster A.J."/>
                <person name="Van der Lee T.A.J."/>
                <person name="Grimwood J."/>
                <person name="Aerts A."/>
                <person name="Antoniw J."/>
                <person name="Bailey A."/>
                <person name="Bluhm B."/>
                <person name="Bowler J."/>
                <person name="Bristow J."/>
                <person name="van der Burgt A."/>
                <person name="Canto-Canche B."/>
                <person name="Churchill A.C.L."/>
                <person name="Conde-Ferraez L."/>
                <person name="Cools H.J."/>
                <person name="Coutinho P.M."/>
                <person name="Csukai M."/>
                <person name="Dehal P."/>
                <person name="De Wit P."/>
                <person name="Donzelli B."/>
                <person name="van de Geest H.C."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Hammond-Kosack K.E."/>
                <person name="Henrissat B."/>
                <person name="Kilian A."/>
                <person name="Kobayashi A.K."/>
                <person name="Koopmann E."/>
                <person name="Kourmpetis Y."/>
                <person name="Kuzniar A."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Maliepaard C."/>
                <person name="Martins N."/>
                <person name="Mehrabi R."/>
                <person name="Nap J.P.H."/>
                <person name="Ponomarenko A."/>
                <person name="Rudd J.J."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Schouten H.J."/>
                <person name="Shapiro H."/>
                <person name="Stergiopoulos I."/>
                <person name="Torriani S.F.F."/>
                <person name="Tu H."/>
                <person name="de Vries R.P."/>
                <person name="Waalwijk C."/>
                <person name="Ware S.B."/>
                <person name="Wiebenga A."/>
                <person name="Zwiers L.-H."/>
                <person name="Oliver R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Kema G.H.J."/>
            </authorList>
            <dbReference type="PubMed" id="21695235"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002070"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 115943 / IPO323</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CM001204">
        <property type="protein sequence ID" value="EGP84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003849265.1">
        <property type="nucleotide sequence ID" value="XM_003849217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9XJT3"/>
    <dbReference type="STRING" id="336722.F9XJT3"/>
    <dbReference type="GeneID" id="13402639"/>
    <dbReference type="KEGG" id="ztr:MYCGRDRAFT_47858"/>
    <dbReference type="VEuPathDB" id="FungiDB:ZTRI_9.30"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_9_0_1"/>
    <dbReference type="InParanoid" id="F9XJT3"/>
    <dbReference type="OMA" id="CFAFSDH"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008062">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGP84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008062"/>
        </source>
    </evidence>
    <sequence length="494" mass="54580" checksum="3D70D8F6D4CA31C5" modified="2011-10-19" version="1">MSPPRSSEGYLYDASGPSCRGLPTEAVVQGSLHTRSSYDVVVIGAGFAGLVAARDVALDRNLRVLLLEARDRIGGRTWVAKAWGEDFEMGGTYVHWCQPHVFGELHRHGLEKDLKTSAGTTATEYINYKPKEKKDTQRVSDVAKYNAMLVDVAEKFFSIDDMTPRQVMPYPHEPSRNQPWQRYDHMSAQDRLDQLDIPQDEKDMFSAHVSSFGSGPASETAWVDTLRWYALGGYGFPTMYDAAASFKIGNGGTTNLCRHILSEYNGDVVMNKQVTSLTQADGSGALIKCVDGSNFTARRVICTIPLNCLGDIKFDPPLSIAKQEAVKRGHMNIGEKYHFSMDEVQGNWFANTSPHGGADFVFGLKDHDGTQSSIKQGTYAMCFGKNGKLADPTNYELVISEYKKLQPEGRVKGYLSHTWSKDPYAKGAWFCASPNMTKHL